24:
33:
397:
253:
639:
634:
1182:(urethane) links. The two isocyanate groups in Toluene diisocyanate react at different rates: The 4-position is approximately four times more reactive than the 2-position. 2,6-TDI is a symmetrical molecule and thus has two isocyanate groups of similar reactivity, similar to the 2-position on 2,4-TDI. However, since both isocyanate groups are attached to the same aromatic ring, reaction of one isocyanate group will cause a change in the reactivity of the second isocyanate group.
629:
624:
850:
1159:
1042:
855:
854:
1239:
Information is available on handling, personal protective equipment, exposure monitoring, transport, storage, sampling and analysis of TDI, dealing with accidents, and health and environmental themes. All major producers of TDI are members of the
International Isocyanate Institute, whose aim is the
853:
1165:
Distillation of the raw TDI mixture produces an 80:20 mixture of 2,4-TDI and 2,6-TDI, known as TDI (80/20). Differentiation or separation of the TDI (80/20) can be used to produce pure 2,4-TDI and a 65:35 mixture of 2,4-TDI and 2,6-TDI, known as TDI (65/35).
1232:, due to the classification of toluene diisocyanate as a possible occupational carcinogen. This chemical was one of many that were stored by the company whose chemical warehouse stationed in Tianjin, China was the site of
1113:(CAS: 91-08-7). 2,4-TDI is produced in the pure state, but TDI is often marketed as 80/20 and 65/35 mixtures of the 2,4 and 2,6 isomers respectively. It is produced on a large scale, accounting for 34.1% of the global
647:
604:
773:
1008:
856:
769:
1324:
1302:
1225:
942:
1055:
1373:
1406:
1121:. Approximately 1.4 billion kilograms were produced in 2000. All isomers of TDI are colorless, although commercial samples can appear yellow.
1217:
464:
32:
1420:
871:
878:
1213:
of 610 mg/m for the vapour. Despite the indicated low toxicity, TDI is classified as "very toxic" by the
European Community.
765:
1050:
23:
1492:
1350:
1244:
131:
123:
1558:
1390:
419:
864:
1062:
809:
1266:
1118:
1004:
1190:
Toluene diisocyanate is used in the production of rigid polyurethane foams with a high temperature stability.
707:
334:
248:
201:
193:
374:
745:
638:
1568:
1563:
1400:
1256:
1229:
1221:
966:
953:
717:
687:
633:
801:
260:
737:
1458:
821:
405:
392:
1261:
1233:
1012:
623:
222:
661:
616:
805:
757:
1548:
1428:
797:
628:
352:
344:
45:
785:
230:
8:
1516:
1511:
777:
90:
79:
396:
252:
172:
164:
98:
1529:, from the website of the National Institute for Occupational Safety and Health (NIOSH)
1194:
1138:
143:
1553:
1488:
1441:
1386:
1346:
1150:
1240:
promotion of the safe handling of TDI in the workplace, community, and environment.
1378:
1082:
789:
781:
578:
492:
1485:
MDI and TDI: Safety, Health and the
Environment: A Source Book and Practical Guide
1444:"Documentation for Immediately Dangerous To Life or Health Concentrations (IDLHs)"
296:
900:
304:
1526:
1134:
1033:
725:
699:
589:
1521:
1298:
924:
721:
1542:
1482:
1443:
1382:
1316:
733:
567:
557:
241:
749:
1024:
877:
890:
793:
863:
761:
1459:"Tianjin explosion: Dozens dead, areas of Chinese port city devastated"
1175:
1114:
998:
870:
519:
261:
212:
1153:
as a byproduct and is a major source of industrial hydrochloric acid.
817:
448:
2,6: InChI=1S/C9H6N2O2/c1-7-8(10-5-12)3-2-4-9(7)11-6-13/h2-4H,1H3
1179:
713:
438:
2,4: InChI=1/C9H6N2O2/c1-7-2-3-8(10-5-12)4-9(7)11-6-13/h2-4H,1H3
363:
1032:
Except where otherwise noted, data are given for materials in their
1146:
836:
1442:
National
Institute for Occupational Safety and Health (May 1994).
1296:
829:
130:
122:
1130:
729:
671:
547:
282:
1483:
Allport, D. C.; Gilbert, D. S.; Outterside, S. M., eds. (2003).
1533:
1158:
1102:
741:
183:
1457:
Ripley, Will; Jiang, Steven; Mullen, Jethro (13 August 2023).
691:
1321:
Immediately
Dangerous to Life or Health Concentrations (IDLH)
813:
315:
154:
111:
1178:
functional groups in TDI react with hydroxyl groups to form
1169:
428:
InChI=1S/C9H6N2O2/c1-7-2-3-8(10-5-12)4-9(7)11-6-13/h2-4H,1H3
379:
1210:
1206:
979:
679:
537:
753:
695:
1224:
with a ceiling at 0.02 ppm (0.14 mg/m), while the
675:
1325:
National
Institute for Occupational Safety and Health
1303:
National
Institute for Occupational Safety and Health
1226:
National
Institute for Occupational Safety and Health
667:
1340:
1456:
1540:
1370:
1209:for TDI is 5800 mg/kg for oral contact and
303:
295:
852:
97:
89:
1374:Ullmann's Encyclopedia of Industrial Chemistry
825:
683:
1446:. Centers for Disease Control and Prevention.
1371:Six, C.; Richter, F. "Isocyanates, Organic".
1218:Occupational Safety and Health Administration
1405:: CS1 maint: multiple names: authors list (
1532:International Isocyanate Institute http://
1527:NIOSH Safety and Health Topic: Isocyanates
1170:Description and description of reactivity
1157:
562:21.8 °C (71.2 °F; 294.9 K)
395:
251:
229:
221:
1366:
1364:
1362:
1336:
1334:
1141:(TDA). Finally, the TDA is subjected to
351:
343:
1297:NIOSH Pocket Guide to Chemical Hazards.
1129:2,4-TDI is prepared in three steps from
1517:IARC Monograph: "Toluene Diisocyanates"
1512:International Chemical Safety Card 0339
404:
391:
1541:
1522:NIOSH Pocket Guide to Chemical Hazards
1359:
1331:
1292:
1290:
1288:
1286:
1284:
1282:
1149:to form TDI. This final step produces
895:127 °C (261 °F; 400 K)
572:251 °C (484 °F; 524 K)
242:
1245:reactive airways dysfunction syndrome
1234:massive explosions on August 12, 2015
451:Key: RUELTTOHQODFPA-UHFFFAOYSA-N
431:Key: DVKJHBMWWAPEIU-UHFFFAOYSA-N
200:
192:
171:
163:
1279:
441:Key: DVKJHBMWWAPEIU-UHFFFAOYAL
285:
13:
1243:High-level exposure can result in
848:
477:2,6: CC1=C(C=CC=C1N=C=O)N=C=O
14:
1580:
1505:
472:2,4: Cc1ccc(cc1\N=C=O)\N=C=O
1040:
637:
632:
627:
622:
50:2,4-Diisocyanato-1-methylbenzene
31:
22:
1267:Methylene diphenyl diisocyanate
1185:
1117:market in 2000, second only to
1036:(at 25 °C , 100 kPa).
1005:Methylene diphenyl diisocyanate
67:2,4-Di(nitrogencarbonyl)toluene
1476:
1450:
1435:
1413:
1309:
1:
1341:Randall, D.; Lee, S. (2003).
1272:
1193:It is also sometimes used in
947:(US health exposure limits):
63:Methyl phenylene diisocyanate
1124:
1105:are commercially important:
7:
1250:
933:13.9 ppm (guinea pig, 4 hr)
913:or concentration (LD, LC):
10:
1585:
1317:"Toluene-2,4-diisocyanate"
1257:Hexamethylene diisocyanate
1230:recommended exposure limit
1222:permissible exposure limit
1216:In the United States, the
1200:
1101:. Two of the six possible
65:Benzylene 2,4-diisocyanate
1559:IARC Group 2B carcinogens
1030:
990:
941:
909:
603:
598:
524:174.2 g/mol
485:
460:
415:
72:
56:
44:
39:
30:
21:
17:Toluene-2,4-diisocyanate
1383:10.1002/14356007.a14_611
1009:Naphthalene diisocyanate
708:Precautionary statements
61:Toluene-2,4-diisocyanate
1377:. Weinheim: Wiley-VCH.
1262:Isophorone diisocyanate
1145:, i.e., treatment with
1013:1,3-Diisocyanatobenzene
960:C 0.02 ppm (0.14 mg/m)
1343:The Polyurethanes Book
1228:has not established a
937:11 ppm (rabbit, 4 hr)
859:
1534:www.diisocyanates.org
1421:"Ababil-100/Al Fat'h"
935:9.7 ppm (mouse, 4 hr)
858:
1109:(CAS: 584-84-9) and
1075:Toluene diisocyanate
925:median concentration
841:(fire diamond)
59:Toluene diisocyanate
46:Preferred IUPAC name
1345:. New York: Wiley.
1085:with the formula CH
579:Solubility in water
552:1.214 g/cm, liquid
326:2,6: CZ6310000
323:2,4: CZ6300000
273:2,6: 202-039-0
270:2,4: 209-544-5
144:Beilstein Reference
18:
1425:GlobalSecurity.org
1195:rocket propellants
1139:2,4-diaminotoluene
1063:Infobox references
991:Related compounds
982:(Immediate danger)
931:14 ppm (rat, 4 hr)
860:
16:
1569:4-Tolyl compounds
1564:2-Tolyl compounds
1494:978-0-471-95812-3
1431:on 15 April 2019.
1401:cite encyclopedia
1352:978-0-470-85041-1
1071:Chemical compound
1069:
1068:
1020:Related compounds
662:Hazard statements
594:0.01 mmHg (25°C)
532:Colorless liquid
375:CompTox Dashboard
132:Interactive image
124:Interactive image
1576:
1499:
1498:
1480:
1474:
1473:
1471:
1469:
1454:
1448:
1447:
1439:
1433:
1432:
1427:. Archived from
1417:
1411:
1410:
1404:
1396:
1368:
1357:
1356:
1338:
1329:
1328:
1313:
1307:
1306:
1294:
1161:
1083:organic compound
1053:
1047:
1044:
1043:
901:Explosive limits
880:
873:
866:
851:
831:
827:
823:
819:
815:
811:
807:
803:
799:
795:
791:
787:
783:
779:
775:
771:
767:
763:
759:
755:
751:
747:
743:
739:
735:
731:
727:
723:
719:
715:
701:
697:
693:
689:
685:
681:
677:
673:
669:
641:
636:
631:
626:
493:Chemical formula
408:
400:
399:
383:
381:
355:
347:
307:
299:
287:
263:
255:
244:
233:
225:
204:
196:
175:
167:
134:
126:
101:
93:
35:
26:
19:
15:
1584:
1583:
1579:
1578:
1577:
1575:
1574:
1573:
1539:
1538:
1508:
1503:
1502:
1495:
1481:
1477:
1467:
1465:
1455:
1451:
1440:
1436:
1419:
1418:
1414:
1398:
1397:
1393:
1369:
1360:
1353:
1339:
1332:
1315:
1314:
1310:
1295:
1280:
1275:
1253:
1203:
1188:
1172:
1127:
1100:
1096:
1092:
1088:
1072:
1065:
1060:
1059:
1058: ?)
1049:
1045:
1041:
1037:
1021:
1007:
1001:
983:
970:
957:
936:
934:
932:
928:
922:
885:
884:
883:
882:
875:
868:
861:
857:
849:
710:
664:
650:
619:
581:
542:sharp, pungent
513:
509:
505:
501:
495:
481:
478:
473:
468:
467:
456:
453:
452:
449:
443:
442:
439:
433:
432:
429:
423:
422:
411:
384:
377:
358:
329:
310:
288:
276:
236:
207:
178:
146:
137:
115:
104:
82:
68:
66:
64:
62:
60:
52:
51:
12:
11:
5:
1582:
1572:
1571:
1566:
1561:
1556:
1551:
1537:
1536:
1530:
1524:
1519:
1514:
1507:
1506:External links
1504:
1501:
1500:
1493:
1475:
1449:
1434:
1412:
1392:978-3527306732
1391:
1358:
1351:
1330:
1308:
1277:
1276:
1274:
1271:
1270:
1269:
1264:
1259:
1252:
1249:
1202:
1199:
1187:
1184:
1171:
1168:
1163:
1162:
1135:dinitrotoluene
1126:
1123:
1098:
1094:
1090:
1086:
1070:
1067:
1066:
1061:
1039:
1038:
1034:standard state
1031:
1028:
1027:
1022:
1019:
1016:
1015:
1002:
996:
993:
992:
988:
987:
984:
978:
975:
974:
971:
965:
962:
961:
958:
952:
949:
948:
939:
938:
929:
920:
918:
915:
914:
907:
906:
903:
897:
896:
893:
887:
886:
876:
869:
862:
847:
846:
845:
844:
842:
833:
832:
774:P305+P351+P338
711:
706:
703:
702:
665:
660:
657:
656:
651:
646:
643:
642:
620:
615:
612:
611:
601:
600:
596:
595:
592:
590:Vapor pressure
586:
585:
582:
577:
574:
573:
570:
564:
563:
560:
554:
553:
550:
544:
543:
540:
534:
533:
530:
526:
525:
522:
516:
515:
511:
507:
503:
499:
496:
491:
488:
487:
483:
482:
480:
479:
476:
474:
471:
463:
462:
461:
458:
457:
455:
454:
450:
447:
446:
444:
440:
437:
436:
434:
430:
427:
426:
418:
417:
416:
413:
412:
410:
409:
401:
387:
385:
373:
370:
369:
366:
360:
359:
357:
356:
348:
339:
337:
331:
330:
328:
327:
324:
320:
318:
312:
311:
309:
308:
300:
291:
289:
281:
278:
277:
275:
274:
271:
267:
265:
257:
256:
246:
238:
237:
235:
234:
226:
217:
215:
209:
208:
206:
205:
197:
188:
186:
180:
179:
177:
176:
168:
159:
157:
151:
150:
147:
142:
139:
138:
136:
135:
127:
118:
116:
109:
106:
105:
103:
102:
94:
85:
83:
78:
75:
74:
70:
69:
58:
54:
53:
49:
48:
42:
41:
37:
36:
28:
27:
9:
6:
4:
3:
2:
1581:
1570:
1567:
1565:
1562:
1560:
1557:
1555:
1552:
1550:
1547:
1546:
1544:
1535:
1531:
1528:
1525:
1523:
1520:
1518:
1515:
1513:
1510:
1509:
1496:
1490:
1486:
1479:
1464:
1460:
1453:
1445:
1438:
1430:
1426:
1422:
1416:
1408:
1402:
1394:
1388:
1384:
1380:
1376:
1375:
1367:
1365:
1363:
1354:
1348:
1344:
1337:
1335:
1326:
1322:
1318:
1312:
1304:
1300:
1293:
1291:
1289:
1287:
1285:
1283:
1278:
1268:
1265:
1263:
1260:
1258:
1255:
1254:
1248:
1246:
1241:
1237:
1235:
1231:
1227:
1223:
1219:
1214:
1212:
1208:
1198:
1196:
1191:
1183:
1181:
1177:
1167:
1160:
1156:
1155:
1154:
1152:
1148:
1144:
1140:
1136:
1132:
1122:
1120:
1116:
1112:
1108:
1104:
1084:
1080:
1076:
1064:
1057:
1052:
1035:
1029:
1026:
1023:
1018:
1017:
1014:
1010:
1006:
1003:
1000:
995:
994:
989:
985:
981:
977:
976:
972:
969:(Recommended)
968:
964:
963:
959:
956:(Permissible)
955:
951:
950:
946:
945:
940:
930:
926:
917:
916:
912:
908:
904:
902:
899:
898:
894:
892:
889:
888:
881:
874:
867:
843:
840:
839:
835:
834:
712:
709:
705:
704:
666:
663:
659:
658:
655:
652:
649:
645:
644:
640:
635:
630:
625:
621:
618:
614:
613:
609:
607:
602:
597:
593:
591:
588:
587:
583:
580:
576:
575:
571:
569:
568:Boiling point
566:
565:
561:
559:
558:Melting point
556:
555:
551:
549:
546:
545:
541:
539:
536:
535:
531:
528:
527:
523:
521:
518:
517:
497:
494:
490:
489:
484:
475:
470:
469:
466:
459:
445:
435:
425:
424:
421:
414:
407:
406:DTXSID2026157
402:
398:
394:
393:DTXSID7026156
389:
388:
386:
376:
372:
371:
367:
365:
362:
361:
354:
349:
346:
341:
340:
338:
336:
333:
332:
325:
322:
321:
319:
317:
314:
313:
306:
301:
298:
293:
292:
290:
284:
280:
279:
272:
269:
268:
266:
264:
259:
258:
254:
250:
247:
245:
243:ECHA InfoCard
240:
239:
232:
227:
224:
219:
218:
216:
214:
211:
210:
203:
202:ChEMBL1443390
198:
195:
194:ChEMBL1086446
190:
189:
187:
185:
182:
181:
174:
169:
166:
161:
160:
158:
156:
153:
152:
148:
145:
141:
140:
133:
128:
125:
120:
119:
117:
113:
108:
107:
100:
95:
92:
87:
86:
84:
81:
77:
76:
71:
55:
47:
43:
38:
34:
29:
25:
20:
1484:
1478:
1466:. Retrieved
1462:
1452:
1437:
1429:the original
1424:
1415:
1372:
1342:
1320:
1311:
1242:
1238:
1215:
1204:
1192:
1189:
1186:Applications
1173:
1164:
1143:phosgenation
1142:
1128:
1110:
1106:
1078:
1074:
1073:
1025:Polyurethane
943:
910:
837:
653:
605:
316:RTECS number
73:Identifiers
57:Other names
1549:Isocyanates
999:isocyanates
911:Lethal dose
891:Flash point
648:Signal word
529:Appearance
486:Properties
249:100.008.678
173:CHEBI:53557
165:CHEBI:53556
1543:Categories
1273:References
1220:has set a
1176:isocyanate
1115:isocyanate
617:Pictograms
520:Molar mass
403:2,6:
390:2,4:
353:78243HXH5O
350:2,6:
345:17X7AFZ1GH
342:2,4:
302:2,6:
294:2,4:
228:2,6:
220:2,4:
213:ChemSpider
199:2,6:
191:2,4:
170:2,6:
162:2,4:
129:2,6:
121:2,4:
110:3D model (
96:2,6:
88:2,4:
80:CAS Number
1487:. Wiley.
1468:1 October
1180:carbamate
1125:Synthesis
905:0.9–9.5%
822:P403+P233
810:P342+P311
806:P337+P313
802:P333+P313
798:P332+P313
778:P308+P313
770:P304+P341
766:P304+P340
762:P302+P352
608:labelling
364:UN number
262:EC Number
1554:Monomers
1327:(NIOSH).
1305:(NIOSH).
1251:See also
1147:phosgene
1081:) is an
997:Related
838:NFPA 704
599:Hazards
223:13835351
91:584-84-9
1299:"#0621"
1201:Hazards
1131:toluene
1111:2,6-TDI
1107:2,4-TDI
1103:isomers
1056:what is
1054: (
584:Reacts
548:Density
514:
283:PubChem
149:744602
99:91-08-7
1491:
1389:
1349:
1051:verify
1048:
654:Danger
465:SMILES
184:ChEMBL
40:Names
1097:(NCO)
944:NIOSH
420:InChI
368:2078
297:11443
155:ChEBI
112:JSmol
1489:ISBN
1470:2023
1407:link
1387:ISBN
1347:ISBN
1211:LC50
1207:LD50
1205:The
1174:The
1137:and
1133:via
986:Ca
980:IDLH
830:P501
826:P405
818:P363
814:P362
794:P321
790:P320
786:P312
782:P310
758:P285
754:P284
750:P281
746:P280
742:P273
738:P272
734:P271
730:P264
726:P261
722:P260
718:P202
714:P201
700:H412
696:H351
692:H335
688:H334
684:H330
680:H319
676:H318
672:H317
668:H315
538:Odor
335:UNII
305:7040
231:6773
1463:CNN
1379:doi
1151:HCl
1119:MDI
1079:TDI
973:Ca
967:REL
954:PEL
606:GHS
380:EPA
286:CID
1545::
1461:.
1423:.
1403:}}
1399:{{
1385:.
1361:^
1333:^
1323:.
1319:.
1301:.
1281:^
1247:.
1236:.
1197:.
1011:,
921:50
919:LC
828:,
824:,
820:,
816:,
812:,
808:,
804:,
800:,
796:,
792:,
788:,
784:,
780:,
776:,
772:,
768:,
764:,
760:,
756:,
752:,
748:,
744:,
740:,
736:,
732:,
728:,
724:,
720:,
716:,
698:,
694:,
690:,
686:,
682:,
678:,
674:,
670:,
610::
1497:.
1472:.
1409:)
1395:.
1381::
1355:.
1099:2
1095:3
1093:H
1091:6
1089:C
1087:3
1077:(
1046:Y
927:)
923:(
879:1
872:1
865:3
512:2
510:O
508:2
506:N
504:6
502:H
500:9
498:C
382:)
378:(
114:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
