57:
3540:
3528:
1710:
1572:
1397:
66:
925:
who refused to extend the patent. An Irish court rejected an injunction request to prevent the launch of generic
Emtricitabine/tenofovir prior to the resolution of the case. Despite the expiration of the Gilead Sciences patent, as of 2021, there are still widespread challenges to the availability and
920:
EP0915894B1 expired in July 2018, Gilead
Sciences wished the patent to be extended, however "four rival labs—Teva, Accord Healthcare, Lupin and Mylan—had sought to have that overturned in the courts in Britain", the High Court of England and Wales invalidated Gilead's patent, however the company
583:
The consideration of utilizing emtricitabine/tenofovir as a reduction strategy involves discussion with a health professional who can help the patient navigate the benefits and risks. Patients are advised to discuss any history of bone issues, kidney issues, or hepatitis B infection with their
645:
Emtricitabine/tenofovir is secreted in breast milk. In developed countries, HIV-infected mothers are generally recommended to not breastfeed due to slight risk of mother-to-children HIV transmission. In developing countries, where avoiding breastfeeding may not be an option, the World Health
2248:
955:
In the United
Kingdom, PrEP is widely available to all at-risk groups following the Department for Health and Social Care's decision to make it available across England in 2020. Wales, Scotland, and Northern Ireland made it available in 2017 and 2018.
2281:
903:
inducers requires monitoring of decreased levels and effects of dabigatran. Lamivudine may increase the adverse or toxic effect of emtricitabine. Vincristine used with P-glycoprotein/ABCB1 inducers can decrease the serum concentration of vincristine.
591:. People who start taking emtricitabine/tenofovir see HIV reduction benefits up to 72 hours after starting, but the medicine must be taken for thirty days after a high-risk sexual event to ensure HIV transmission levels are optimally reduced.
2238:
2271:
723:
For patients who weigh more than 60 kg, didanosine dose should be reduced to 250 mg; there is no available data to recommend didanosine dose adjustments in patients who weigh less than 60 kg.
2925:
929:
In 2019, Gilead
Sciences challenged the validity of patents granted to the United States after 2015 for using the drug combination for HIV PrEP and post-exposure prophylaxis (PEP).. In July 2024, The
2313:
2008:
2899:
681:
of the abdomen and accumulations in the upper back. When used as pre-exposure prophylaxis (PrEP) this effect may not be present. Weight changes have however been linked to the medication.
2817:
274:
1035:
1847:"Recommendations for use of antiretroviral drugs in pregnant HIV-1-infected women for maternal health and interventions to reduce perinatal HIV transmission in the United States"
1589:
1759:
1669:"Updated US Public Health Service guidelines for the management of occupational exposures to human immunodeficiency virus and recommendations for postexposure prophylaxis"
1173:
2919:
3109:
1816:
3114:
1539:
3060:
2055:"Pharmacokinetics of emtricitabine, tenofovir, and GS-9137 following coadministration of emtricitabine/tenofovir disoproxil fumarate and ritonavir-boosted GS-9137"
2102:
2196:
3580:
2532:
2169:
1259:
3499:
510:
until 2020, but is now available as a generic worldwide. In 2020, it was the 278th most commonly prescribed medication in the United States, with more than 1
229:
2223:
3575:
2696:
2303:
618:, with the added benefit that they can target HIV for those with co-infection. Emtricitabine/tenofovir may also be considered for some antiviral resistant
1727:
1335:
2127:
1635:"Updated U.S. Public Health Service guidelines for the management of occupational exposures to HIV and recommendations for postexposure prophylaxis"
634:(ART) as early in pregnancy as possible to reduce the risk of transmission. ART generally does not increase risk of birth defects with exception of
3560:
3066:
584:
healthcare provider. Effectiveness of PrEP for prevention of infection is reliant on an individual's ability to take the medication consistently.
3124:
3044:
3129:
1857:
1473:"Preexposure Prophylaxis for the Prevention of HIV Infection: Evidence Report and Systematic Review for the US Preventive Services Task Force"
3077:
2478:
127:
3099:
3083:
945:
677:) has been observed in people receiving antiretroviral therapy, including fat reductions in the face, limbs, and buttocks and increases in
487:
Common side effects include headache, tiredness, trouble sleeping, abdominal pain, weight loss, and rash. Serious side effects may include
984:
3452:
3447:
3094:
1943:
1376:
3104:
1597:
606:. The combination therapy is suggested as one of the options for adults who have not received any prior treatment for HIV infection.
429:
3371:
1766:
602:
Emtricitabine/tenofovir has been approved in the United States as part of antiretroviral combination therapy for the treatment of
570:
Heterosexual men or women who do not regularly use condoms during sex with partners of unknown HIV status who are substantial risk
3015:
2028:
1165:
2336:
1619:
1553:
3470:
3361:
1824:
1130:
503:
2141:
1529:
3119:
2456:
848:
3134:
137:
2392:
1382:
567:
Gay or bisexual men who either have had anal sex without a condom or been diagnosed with an STD in the past six months
2690:
2471:
2224:"European PrEP programs face two big issues: How to get more people coming forward, and how to serve them if they do"
1215:
3487:
3144:
3028:
178:
2421:
3154:
3139:
2802:
2790:
1791:
259:
159:
97:
1966:"Metabolic Effects of Preexposure Prophylaxis With Coformulated Tenofovir Disoproxil Fumarate and Emtricitabine"
1104:
3034:
646:
Organization recommends a triple drug regimen of tenofovir, efavirenz, and either lamivudine or emtricitabine.
553:
systematic review found a similar relative risk reduction of 54% on average and greater reduction with greater
1734:
1346:
952:, this recommendation requires all non-grandfathered private health plans to cover PrEP without cost sharing.
1853:
523:
2155:
2464:
2359:
39:
3239:
1007:"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)"
588:
2360:"New Guidance On PrEP: Support Services Must Be Covered Without Cost-Sharing | Health Affairs Forefront"
1760:"Update on Prevention, Diagnosis, and Treatment of Chronic Hepatitis B: AASLD 2018 Hepatitis B Guidance"
1310:
3518:
917:
534:
The
Centers for Disease Control and Prevention (CDC) recommends the use of emtricitabine/tenofovir for
458:
1964:
Glidden DV, Mulligan K, McMahan V, Anderson PL, Guanira J, Chariyalertsak S, et al. (July 2018).
1620:"Pre-exposure prophylaxis of HIV in adults at high risk: Truvada (emtricitabine/tenofovir disoproxil)"
1231:
1195:
1006:
922:
469:
450:
1846:
3565:
3311:
3221:
3202:
3089:
3050:
1667:
Kuhar DT, Henderson DK, Struble KA, Heneine W, Thomas V, Cheever LW, et al. (September 2013).
535:
473:
940:
In the United States, most healthcare plans are required to cover PrEP without any copay or other
674:
579:
heterosexual and homosexual partners. where one partner is HIV-positive and the other HIV-negative
415:
3475:
3071:
930:
546:
539:
215:
109:
17:
669:
Common: headache, abdominal pain, decreased weight, nausea, diarrhea, and decreased bone density
502:
Emtricitabine/tenofovir was approved for medical use in the United States in 2004. It is on the
3149:
1882:
976:
594:
Emtricitabine/tenofovir as PrEP should not be used for individuals who are positive for HIV-1.
447:
3257:
1036:"Prescription medicines: registration of new generic medicines and biosimilar medicines, 2017"
3570:
3346:
3159:
3039:
2909:
2508:
765:
638:, which is not recommended during first trimester of pregnancy only due to potential risk of
538:(PrEP) for uninfected, HIV-1 negative individuals that may be at risk for HIV-1 infection. A
1416:"Antiretroviral pre-exposure prophylaxis (PrEP) for preventing HIV in high-risk individuals"
1061:
549:
of contracting HIV with both tenofovir alone and the tenofovir/emtricitabine combination. A
350:
3229:
3055:
2904:
2662:
2337:"Biden administration appeals jury finding in battle over patents for HIV prevention pills"
888:
554:
465:
91:
2486:
1668:
873:
May inhibit the absorption of emtricitabine/tenofovir and result in loss of viral control.
8:
3164:
3023:
2895:
2813:
2612:
2491:
2276:
2243:
949:
856:
753:, atazanavir coadministered with ritonavir & darunavir coadministered with ritonavir
750:
481:
341:
222:
56:
1440:
1415:
48:
2448:
2084:
1990:
1965:
1699:
1510:
1453:
654:
Emtricitabine/tenofovir is generally well tolerated. Some of its side effects include:
639:
603:
189:
2371:
3306:
2969:
2076:
1995:
1918:
1691:
1649:
1534:
1514:
1502:
1494:
1471:
Chou R, Evans C, Hoverman A, Sun C, Dana T, Bougatsos C, et al. (11 June 2019).
1445:
1211:
740:
Atazanavir should only be taken together with emtricitabine/tenofovir with ritonavir.
542:
375:
298:
286:
151:
2088:
1728:"Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents with HIV"
1703:
1557:
1457:
1336:"Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents with HIV"
1166:"Truvada- emtricitabine and tenofovir disoproxil fumarate tablet, film coated label"
3331:
2367:
2239:"Gilead defied a government HIV patent. The Justice Department has opened a review"
2066:
1985:
1977:
1683:
1484:
1435:
1431:
1427:
1239:
1203:
630:
In the United States, it is recommended that all pregnant HIV-infected women start
242:
3505:
2435:
2128:"U.K. Court invalidates Gilead's Truvada patent extension, allowing PrEP generics"
1285:
1126:
3532:
3407:
3366:
2526:
2308:
2201:
2174:
2071:
2054:
934:
913:
659:
507:
488:
1910:
720:
Discontinue didanosine if patient develops didanosine-associated adverse events.
522:
Emtricitabine/tenofovir is used both to treat and to prevent HIV/AIDS. The U.S.
3544:
3481:
2487:
1792:"Emtricitabine and Tenofovir Disoproxil Fumarate (Professional Patient Advice)"
900:
832:
828:
792:
631:
576:
557:. It was approved for PrEP against HIV infection in the United States in 2012.
3554:
3247:
2997:
2832:
2718:
1714:
1634:
1576:
1498:
1401:
461:
311:
78:
713:
May increase didanosine concentration and risk of didanosine toxicity (e.g.
526:(NIH) recommends antiretroviral therapy (ART) for all people with HIV/AIDS.
3301:
3291:
2872:
2862:
2680:
2637:
2632:
2627:
2589:
2569:
2499:
2080:
1999:
1922:
1695:
1653:
1506:
1489:
1472:
1449:
1371:
1236:
World Health
Organization model list of essential medicines: 21st list 2019
941:
824:
714:
678:
635:
492:
406:
237:
1633:
Panlilio AL, Cardo DM, Grohskopf LA, Heneine W, Ross CS (September 2005).
564:
Individuals in an ongoing sexual relationship with an HIV-positive partner
560:
The CDC recommends PrEP be considered for the following high-risk groups:
3427:
3402:
3341:
3326:
3321:
2985:
2952:
2867:
2847:
2642:
2622:
2601:
2548:
2516:
1981:
896:
820:
776:
663:
619:
615:
145:
30:
This article is about the combination medication emtricitabine/tenofovir
1244:
3432:
3412:
3397:
3392:
3356:
3351:
3265:
3210:
3180:
2992:
2980:
2975:
2947:
2887:
2877:
2852:
2837:
2827:
2776:
2771:
2759:
2743:
2733:
2713:
2675:
2585:
2573:
2565:
1207:
892:
876:
Monitor HIV viral load frequently while the patient is taking orlistat.
730:
706:
499:
does not appear to harm the fetus, but this has not been well studied.
480:
practices. It does not cure HIV/AIDS. Emtricitabine/tenofovir is taken
83:
2272:"Gilead files challenge to government patents for HIV prevention pill"
1260:"AOC asks pharma CEO why $ 2,000 HIV drug costs just $ 8 in Australia"
3442:
3422:
3417:
3387:
3316:
3296:
3185:
2942:
2857:
2842:
2765:
2738:
2728:
2723:
2670:
2647:
2560:
1096:
816:
808:
496:
477:
361:
131:
2197:"Gilead in row with generics manufacturers over HIV drug in Ireland"
795:
and breast cancer resistance protein (BCRP) transporters inhibitors
614:
Both emtricitabine and tenofovir are indicated for the treatment of
506:. In the United States, emtricitabine/tenofovir was under patent by
3437:
2822:
1687:
866:
812:
573:
Injection of drugs in the last six months with sharing of equipment
454:
395:
173:
2170:"Gilead loss of generic HIV drug battle a boost for gay community"
1944:"PrEP does not raise lipids or alter body fat, safety study finds"
1590:"Administration of pre-exposure prophylaxis against HIV infection"
3336:
2882:
2652:
2304:"Petitions to US Patent and Trademark Office on HIV PrEP Patents"
1713:
This article incorporates text from this source, which is in the
1575:
This article incorporates text from this source, which is in the
1400:
This article incorporates text from this source, which is in the
977:"Emtricitabine / tenofovir Pregnancy and Breastfeeding Warnings"
3286:
3281:
1963:
737:
May decrease atazanavir and increase tenofovir concentrations.
476:, in those who are at high risk, it is recommended along with
2596:
2142:"Truvada ruling could allow cheap HIV prevention in the UK -"
1632:
1311:"Emtricitabine; Tenofovir Disoproxil - Drug Usage Statistics"
3539:
2156:"EU door opens for generic version of AIDS medicine Truvada"
1666:
3110:
Elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide
2555:
2543:
840:
May increase emtricitabine and/or tenofovir concentrations.
550:
468:. For treatment, it must be used in combination with other
386:
3115:
Elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil
2052:
2009:"Truvada as HIV PrEP not associated with net fat increase"
948:
recommendation that gave PrEP a grade A rating. Under the
65:
2580:
2495:
1230:
1194:
1014:
34:. For the combination medication emtricitabine/tenofovir
3061:
Darunavir/cobicistat/emtricitabine/tenofovir alafenamide
1248:. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
937:
verdict that the U.S. government’s patents are invalid.
2393:"FAQS ABOUT AFFORDABLE CARE ACT IMPLEMENTATION PART 47"
2053:
Ramanathan S, Shen G, Cheng A, Kearney BP (July 2007).
504:
27:
Drug combination for HIV/AIDS prophylaxis and treatment
3516:
1413:
971:
969:
1470:
1160:
1158:
1156:
1154:
1152:
1150:
1148:
1146:
1144:
1142:
1140:
999:
800:
May increase absorption of emtricitabine/tenofovir.
966:
933:appealed the jury finding that ruled in favor of
879:Discontinue orlistat if HIV viral load increases.
3552:
3067:Dolutegravir/emtricitabine/tenofovir alafenamide
1883:"Emtricitabine / tenofovir Use During Pregnancy"
1137:
1129:. Electronic Medicines Compendium. August 2016.
912:The patent for the drug combination is owned by
374:
3125:Emtricitabine/rilpivirine/tenofovir alafenamide
3045:Bictegravir/emtricitabine/tenofovir alafenamide
1198:(2009). Stuart MC, Kouimtzi M, Hill SR (eds.).
1091:
1089:
1087:
1085:
1083:
349:
3130:Emtricitabine/rilpivirine/tenofovir disoproxil
2616:(Integrase strand transfer inhibitors (INSTI))
2422:"HIV drug PrEP to be available across England"
1817:"Brief What's New in the Guidelines Perinatal"
921:appealed and the UK referred the case to the
625:
3581:World Health Organization essential medicines
3078:Dolutegravir/lamivudine/tenofovir alafenamide
2472:
1905:
1903:
1530:"FDA approves first pill to help prevent HIV"
587:Emtricitabine/tenofovir is also used for HIV
3100:Efavirenz/emtricitabine/tenofovir disoproxil
3084:Dolutegravir/lamivudine/tenofovir disoproxil
2400:Centers for Medicare & Medicaid Services
1080:
946:United States Preventive Services Task Force
414:
177:
3576:Pre-exposure prophylaxis for HIV prevention
1917:. National Library of Medicine (US). 2006.
1676:Infection Control and Hospital Epidemiology
1414:Okwundu CI, Uthman OA, Okoromah CA (2012).
926:uptake of generic PrEP throughout Europe.
887:Other drugs with adverse reactions include
328:In general: ℞ (Prescription only)
122:Emtricitabine/tenofovir disoproxil fumarate
3095:Doravirine/lamivudine/tenofovir disoproxil
2479:
2465:
1900:
1377:Centers for Disease Control and Prevention
1202:. World Health Organization. p. 160.
1119:
3105:Efavirenz/lamivudine/tenofovir disoproxil
2334:
2070:
1989:
1488:
1439:
1243:
40:Tenofovir alafenamide § combinations
3372:Zinc finger protein transcription factor
807:Drugs may decrease renal function (e.g.
3561:Fixed dose combination (antiretroviral)
2269:
2236:
1527:
1252:
150:
14:
3553:
2029:"DailyMed - XENICAL- orlistat capsule"
1915:Drugs and Lactation Database (LactMed)
1407:
1224:
1188:
1133:from the original on 20 December 2016.
1127:"UK label Truvada film-coated tablets"
1040:Therapeutic Goods Administration (TGA)
907:
772:May increase tenofovir concentrations.
758:May increase tenofovir concentrations.
320:
292:
2460:
2357:
1238:. Geneva: World Health Organization.
1107:from the original on 20 December 2016
673:Fat redistribution and accumulation (
305:
168:
136:
2316:from the original on 30 October 2019
2284:from the original on 1 November 2019
2251:from the original on 1 November 2019
1385:from the original on 31 October 2019
1176:from the original on 31 October 2019
987:from the original on 10 October 2019
779:antiviral or antiretroviral therapy.
684:
241:
3120:Emtricitabine/tenofovir alafenamide
394:
365:
24:
3135:Emtricitabine/tenofovir disoproxil
2103:"EP0915894B1 - NUCLEOTIDE ANALOGS"
1863:from the original on 12 April 2014
1542:from the original on 19 July 2012.
662:, liver dysfunction, worsening of
25:
3592:
2372:10.1377/forefront.20210728.333084
2312:(Press release). 21 August 2019.
1554:"Pre-Exposure Prophylaxis (PrEP)"
899:. Dabigatran etexilate used with
529:
268:
200:
3538:
3526:
3508:. Formerly or rarely used agent.
3145:Lamivudine/nevirapine/zidovudine
3029:Abacavir/dolutegravir/lamivudine
1708:
1570:
1395:
597:
495:. Use of this medication during
64:
55:
3312:Epigallocatechin gallate (EGCG)
3155:Lamivudine/tenofovir disoproxil
3140:Lamivudine/nevirapine/stavudine
2442:
2428:
2414:
2385:
2351:
2328:
2296:
2263:
2230:
2216:
2189:
2162:
2148:
2134:
2120:
2095:
2046:
2021:
1957:
1936:
1875:
1839:
1809:
1784:
1752:
1720:
1660:
1626:
1612:
1582:
1546:
1521:
1464:
1364:
1328:
1303:
1278:
782:Monitor for tenofovir toxicity.
743:Monitor for tenofovir toxicity.
649:
517:
98:reverse transcriptase inhibitor
86:reverse transcriptase inhibitor
3035:Abacavir/lamivudine/zidovudine
2059:J. Acquir. Immune Defic. Syndr
1432:10.1002/14651858.CD007189.pub3
1054:
1028:
609:
281:
13:
1:
1854:National Institutes of Health
959:
524:National Institutes of Health
2270:Rowland C (21 August 2019).
2072:10.1097/QAI.0b013e318050d88c
1343:AIDSinfo Clinical Guidelines
442:, sold under the brand name
7:
2910:Tenofovir alafenamide (TAF)
2335:Silverman E (8 July 2024).
2237:Rowland C (24 April 2019).
1345:. July 2019. Archived from
626:Pregnancy and breastfeeding
10:
3597:
2905:Tenofovir disoproxil (TDF)
1528:Perrone M (16 July 2012).
1420:Cochrane Database Syst Rev
474:prevention before exposure
470:antiretroviral medications
459:antiretroviral medications
453:used to treat and prevent
29:
3465:
3380:
3274:
3256:
3238:
3220:
3201:
3194:
3173:
3014:
2961:
2935:
2926:Discovery and development
2918:
2801:
2789:
2752:
2706:
2697:Discovery and development
2689:
2661:
2611:
2533:Discovery and development
2525:
2507:
1232:World Health Organization
1196:World Health Organization
1066:European Medicines Agency
923:European Court of Justice
855:May increase the risk of
788:
702:
694:
589:post-exposure prophylaxis
489:high blood lactate levels
451:antiretroviral medication
425:
405:
385:
360:
340:
335:
258:
253:
228:
214:
188:
158:
144:
126:
118:
108:
103:
90:
77:
72:
63:
54:
3222:Transcription inhibitors
3174:Pharmacokinetic boosters
3090:Dolutegravir/rilpivirine
3051:Cabotegravir/rilpivirine
2691:Protease Inhibitors (PI)
2364:Health Affairs Forefront
1200:WHO Model Formulary 2008
789:Emtricitabine/tenofovir
536:pre-exposure prophylaxis
493:enlargement of the liver
3506:initial regimen options
3072:Dolutegravir/lamivudine
2549:Enfuvirtide (ENF, T-20)
2527:Entry/fusion inhibitors
690:Drug-drug interactions
547:relative risk reduction
514:million prescriptions.
440:Emtricitabine/tenofovir
49:Emtricitabine/tenofovir
3347:Portmanteau inhibitors
3240:Translation inhibitors
3150:Lamivudine/raltegravir
2920:Non-nucleoside (NNRTI)
2878:Islatravir (EFdA, ISL)
2436:"Free PrEP on the NHS"
1490:10.1001/jama.2019.2591
847:High-dose or multiple
695:Drug-drug Interaction
632:antiretroviral therapy
448:fixed-dose combination
3362:Synergistic enhancers
3160:Lamivudine/zidovudine
3040:Atazanavir/cobicistat
3016:Combined formulations
2853:Zidovudine (AZT, ZDV)
2791:Reverse-transcriptase
2663:Maturation inhibitors
1286:"The Top 300 of 2020"
916:in some regions. The
775:Consider alternative
766:Ledipasvir/sofosbuvir
3203:Uncoating inhibitors
3056:Darunavir/cobicistat
2896:Nucleotide analogues
2814:Nucleoside analogues
2613:Integrase inhibitors
2492:antiretroviral drugs
2144:. 19 September 2018.
2130:. 19 September 2018.
2033:dailymed.nlm.nih.gov
1538:. Associated Press.
931:Biden administration
889:dabigatran etexilate
466:tenofovir disoproxil
96:Nucleotide analogue
92:Tenofovir disoproxil
3195:Experimental agents
3165:Lopinavir/ritonavir
3024:Abacavir/lamivudine
2998:Elsulfavirine (ESV)
2833:Emtricitabine (FTC)
2719:Fosamprenavir (FPV)
2277:The Washington Post
2244:The Washington Post
2015:. 13 February 2018.
1381:. 17 October 2019.
950:Affordable Care Act
944:. This is due to a
908:Society and culture
857:acute kidney injury
751:Lopinavir/ritonavir
691:
640:neural tube defects
446:among others, is a
301:(Prescription only)
277:(Prescription only)
51:
3492:Never to phase III
2638:Elvitegravir (EVG)
2633:Dolutegravir (DTG)
2628:Cabotegravir (CAB)
2226:. 27 January 2021.
1982:10.1093/cid/ciy083
1827:on 23 October 2019
1772:on 25 January 2020
1740:on 4 December 2016
1600:on 1 November 2019
1352:on 4 December 2016
1068:. 21 February 2005
689:
457:. It contains the
47:
3514:
3513:
3461:
3460:
3307:Diarylpyrimidines
3010:
3009:
3006:
3005:
2986:Rilpivirine (RPV)
2970:diarylpyrimidines
2953:Delavirdine (DLV)
2848:Zalcitabine (ddC)
2805:nucleotide (NRTI)
2785:
2784:
2643:Raltegravir (RAL)
2623:Bictegravir (BIC)
2602:Fostemsavir (FTR)
2517:Lenacapavir (LEN)
2509:Capsid inhibitors
1970:Clin. Infect. Dis
1622:. 5 October 2016.
1535:The Seattle Times
1483:(22): 2214–2230.
983:. 1 August 2018.
885:
884:
698:Coadministration
685:Drug interactions
543:systematic review
437:
436:
324:
309:
296:
284:
272:
204:
171:
16:(Redirected from
3588:
3543:
3542:
3531:
3530:
3529:
3522:
3332:Hydroxycarbamide
3199:
3198:
2993:Doravirine (DOR)
2981:Etravirine (ETR)
2976:Dapivirine (DPV)
2948:Nevirapine (NVP)
2933:
2932:
2838:Lamivudine (3TC)
2828:Didanosine (ddI)
2799:
2798:
2772:Tipranavir (TPV)
2760:Atazanavir (ATV)
2744:Saquinavir (SQV)
2734:Nelfinavir (NFV)
2714:Amprenavir (APV)
2704:
2703:
2586:Ibalizumab (IBA)
2481:
2474:
2467:
2458:
2457:
2451:
2446:
2440:
2439:
2432:
2426:
2425:
2418:
2412:
2411:
2409:
2407:
2397:
2389:
2383:
2382:
2380:
2378:
2358:Keith K (2021).
2355:
2349:
2348:
2346:
2344:
2332:
2326:
2325:
2323:
2321:
2300:
2294:
2293:
2291:
2289:
2267:
2261:
2260:
2258:
2256:
2234:
2228:
2227:
2220:
2214:
2213:
2211:
2209:
2193:
2187:
2186:
2184:
2182:
2166:
2160:
2159:
2152:
2146:
2145:
2138:
2132:
2131:
2124:
2118:
2117:
2115:
2113:
2099:
2093:
2092:
2074:
2050:
2044:
2043:
2041:
2039:
2025:
2019:
2016:
2006:Lay summary in:
2003:
1993:
1961:
1955:
1954:
1952:
1950:
1940:
1934:
1933:
1931:
1929:
1907:
1898:
1897:
1895:
1893:
1879:
1873:
1872:
1870:
1868:
1862:
1851:
1843:
1837:
1836:
1834:
1832:
1823:. Archived from
1813:
1807:
1806:
1804:
1802:
1788:
1782:
1781:
1779:
1777:
1771:
1765:. Archived from
1764:
1756:
1750:
1749:
1747:
1745:
1739:
1733:. Archived from
1732:
1724:
1718:
1712:
1711:
1707:
1673:
1664:
1658:
1657:
1639:
1630:
1624:
1623:
1616:
1610:
1609:
1607:
1605:
1596:. Archived from
1586:
1580:
1574:
1573:
1569:
1567:
1565:
1556:. Archived from
1550:
1544:
1543:
1525:
1519:
1518:
1492:
1468:
1462:
1461:
1443:
1411:
1405:
1399:
1398:
1394:
1392:
1390:
1368:
1362:
1361:
1359:
1357:
1351:
1340:
1332:
1326:
1325:
1323:
1321:
1307:
1301:
1300:
1298:
1296:
1282:
1276:
1275:
1273:
1271:
1256:
1250:
1249:
1247:
1228:
1222:
1221:
1192:
1186:
1185:
1183:
1181:
1162:
1135:
1134:
1123:
1117:
1116:
1114:
1112:
1093:
1078:
1077:
1075:
1073:
1058:
1052:
1051:
1049:
1047:
1032:
1026:
1025:
1023:
1021:
1011:nctr-crs.fda.gov
1003:
997:
996:
994:
992:
973:
692:
688:
513:
433:
432:
418:
398:
378:
368:
367:
353:
322:
319:
314:
307:
304:
294:
291:
283:
280:
270:
267:
245:
202:
199:
181:
170:
167:
154:
140:
68:
59:
52:
50:
46:
21:
3596:
3595:
3591:
3590:
3589:
3587:
3586:
3585:
3566:Gilead Sciences
3551:
3550:
3549:
3537:
3527:
3525:
3517:
3515:
3510:
3509:
3497:
3482:Clinical trials
3457:
3408:Dexelvucitabine
3376:
3367:Tre recombinase
3270:
3252:
3234:
3230:Tat antagonists
3216:
3190:
3169:
3002:
2957:
2943:Efavirenz (EFV)
2922:
2914:
2843:Stavudine (d4T)
2804:
2792:
2781:
2766:Darunavir (DRV)
2748:
2739:Ritonavir (RTV)
2729:Lopinavir (LPV)
2724:Indinavir (IDV)
2693:
2685:
2657:
2615:
2607:
2561:Maraviroc (MVC)
2529:
2521:
2503:
2488:Antiviral drugs
2485:
2455:
2454:
2449:Generic Sovaldi
2447:
2443:
2434:
2433:
2429:
2420:
2419:
2415:
2405:
2403:
2395:
2391:
2390:
2386:
2376:
2374:
2356:
2352:
2342:
2340:
2333:
2329:
2319:
2317:
2309:Gilead Sciences
2302:
2301:
2297:
2287:
2285:
2268:
2264:
2254:
2252:
2235:
2231:
2222:
2221:
2217:
2207:
2205:
2202:The Irish Times
2195:
2194:
2190:
2180:
2178:
2175:The Irish Times
2168:
2167:
2163:
2154:
2153:
2149:
2140:
2139:
2135:
2126:
2125:
2121:
2111:
2109:
2101:
2100:
2096:
2051:
2047:
2037:
2035:
2027:
2026:
2022:
2007:
1962:
1958:
1948:
1946:
1942:
1941:
1937:
1927:
1925:
1909:
1908:
1901:
1891:
1889:
1881:
1880:
1876:
1866:
1864:
1860:
1849:
1845:
1844:
1840:
1830:
1828:
1815:
1814:
1810:
1800:
1798:
1790:
1789:
1785:
1775:
1773:
1769:
1762:
1758:
1757:
1753:
1743:
1741:
1737:
1730:
1726:
1725:
1721:
1709:
1671:
1665:
1661:
1642:MMWR Recomm Rep
1637:
1631:
1627:
1618:
1617:
1613:
1603:
1601:
1588:
1587:
1583:
1571:
1563:
1561:
1552:
1551:
1547:
1526:
1522:
1469:
1465:
1426:(7): CD007189.
1412:
1408:
1396:
1388:
1386:
1370:
1369:
1365:
1355:
1353:
1349:
1338:
1334:
1333:
1329:
1319:
1317:
1309:
1308:
1304:
1294:
1292:
1284:
1283:
1279:
1269:
1267:
1264:The Independent
1258:
1257:
1253:
1229:
1225:
1218:
1193:
1189:
1179:
1177:
1172:. 18 May 2018.
1164:
1163:
1138:
1125:
1124:
1120:
1110:
1108:
1095:
1094:
1081:
1071:
1069:
1060:
1059:
1055:
1045:
1043:
1034:
1033:
1029:
1019:
1017:
1005:
1004:
1000:
990:
988:
975:
974:
967:
962:
935:Gilead Sciences
918:European patent
914:Gilead Sciences
910:
833:aminoglycosides
687:
660:lactic acidosis
652:
628:
612:
600:
532:
520:
511:
428:
426:
421:
401:
381:
364:
356:
331:
312:
249:
217:
210:
191:
184:
114:Truvada, others
43:
28:
23:
22:
15:
12:
11:
5:
3594:
3584:
3583:
3578:
3573:
3568:
3563:
3548:
3547:
3535:
3512:
3511:
3496:
3495:
3494:
3493:
3490:
3479:
3473:
3467:
3466:
3463:
3462:
3459:
3458:
3456:
3455:
3450:
3445:
3440:
3435:
3430:
3425:
3420:
3415:
3410:
3405:
3400:
3395:
3390:
3384:
3382:
3378:
3377:
3375:
3374:
3369:
3364:
3359:
3354:
3349:
3344:
3339:
3334:
3329:
3324:
3319:
3314:
3309:
3304:
3299:
3294:
3289:
3284:
3278:
3276:
3272:
3271:
3269:
3268:
3262:
3260:
3254:
3253:
3251:
3250:
3244:
3242:
3236:
3235:
3233:
3232:
3226:
3224:
3218:
3217:
3215:
3214:
3207:
3205:
3196:
3192:
3191:
3189:
3188:
3183:
3181:Cobicistat (c)
3177:
3175:
3171:
3170:
3168:
3167:
3162:
3157:
3152:
3147:
3142:
3137:
3132:
3127:
3122:
3117:
3112:
3107:
3102:
3097:
3092:
3087:
3081:
3075:
3069:
3064:
3058:
3053:
3048:
3042:
3037:
3032:
3026:
3020:
3018:
3012:
3011:
3008:
3007:
3004:
3003:
3001:
3000:
2995:
2990:
2989:
2988:
2983:
2978:
2965:
2963:
2959:
2958:
2956:
2955:
2950:
2945:
2939:
2937:
2930:
2916:
2915:
2913:
2912:
2907:
2891:
2890:
2885:
2880:
2875:
2870:
2865:
2860:
2855:
2850:
2845:
2840:
2835:
2830:
2825:
2823:Abacavir (ABC)
2809:
2807:
2803:Nucleoside and
2796:
2787:
2786:
2783:
2782:
2780:
2779:
2774:
2769:
2763:
2756:
2754:
2750:
2749:
2747:
2746:
2741:
2736:
2731:
2726:
2721:
2716:
2710:
2708:
2701:
2687:
2686:
2684:
2683:
2678:
2673:
2667:
2665:
2659:
2658:
2656:
2655:
2650:
2645:
2640:
2635:
2630:
2625:
2619:
2617:
2609:
2608:
2606:
2605:
2593:
2577:
2563:
2552:
2539:
2537:
2523:
2522:
2520:
2519:
2513:
2511:
2505:
2504:
2484:
2483:
2476:
2469:
2461:
2453:
2452:
2441:
2427:
2413:
2402:. 19 July 2021
2384:
2350:
2327:
2295:
2262:
2229:
2215:
2188:
2161:
2147:
2133:
2119:
2094:
2045:
2020:
2018:
2017:
1976:(3): 411–419.
1956:
1935:
1899:
1874:
1838:
1808:
1783:
1751:
1719:
1688:10.1086/672271
1659:
1648:(RR-9): 1–17.
1625:
1611:
1581:
1560:on 5 June 2015
1545:
1520:
1463:
1406:
1363:
1327:
1302:
1277:
1251:
1223:
1216:
1187:
1136:
1118:
1079:
1062:"Truvada EPAR"
1053:
1042:. 21 June 2022
1027:
998:
964:
963:
961:
958:
909:
906:
901:p-glycoprotein
883:
882:
881:
880:
877:
874:
869:
863:
862:
861:
860:
851:
844:
843:
842:
841:
836:
829:valganciclovir
804:
803:
802:
801:
796:
793:P-glycoprotein
790:
786:
785:
784:
783:
780:
773:
768:
762:
761:
760:
759:
754:
747:
746:
745:
744:
741:
738:
733:
727:
726:
725:
724:
721:
718:
717:, neuropathy).
709:
704:
700:
699:
696:
686:
683:
671:
670:
667:
651:
648:
627:
624:
611:
608:
599:
596:
581:
580:
577:Serodiscordant
574:
571:
568:
565:
531:
530:HIV prevention
528:
519:
516:
435:
434:
423:
422:
420:
419:
411:
409:
403:
402:
400:
399:
391:
389:
383:
382:
380:
379:
371:
369:
358:
357:
355:
354:
346:
344:
338:
337:
333:
332:
330:
329:
326:
317:
302:
289:
278:
264:
262:
256:
255:
251:
250:
248:
247:
234:
232:
226:
225:
220:
218:administration
212:
211:
209:
208:
206:
196:
194:
186:
185:
183:
182:
164:
162:
156:
155:
148:
142:
141:
134:
124:
123:
120:
116:
115:
112:
106:
105:
101:
100:
94:
88:
87:
81:
75:
74:
73:Combination of
70:
69:
61:
60:
26:
9:
6:
4:
3:
2:
3593:
3582:
3579:
3577:
3574:
3572:
3569:
3567:
3564:
3562:
3559:
3558:
3556:
3546:
3541:
3536:
3534:
3524:
3523:
3520:
3507:
3504:
3501:
3491:
3489:
3486:
3485:
3483:
3480:
3477:
3474:
3472:
3469:
3468:
3464:
3454:
3451:
3449:
3446:
3444:
3441:
3439:
3436:
3434:
3431:
3429:
3426:
3424:
3421:
3419:
3416:
3414:
3411:
3409:
3406:
3404:
3401:
3399:
3396:
3394:
3391:
3389:
3386:
3385:
3383:
3381:Failed agents
3379:
3373:
3370:
3368:
3365:
3363:
3360:
3358:
3355:
3353:
3350:
3348:
3345:
3343:
3340:
3338:
3335:
3333:
3330:
3328:
3325:
3323:
3320:
3318:
3315:
3313:
3310:
3308:
3305:
3303:
3300:
3298:
3295:
3293:
3290:
3288:
3285:
3283:
3280:
3279:
3277:
3273:
3267:
3264:
3263:
3261:
3259:
3255:
3249:
3248:Trichosanthin
3246:
3245:
3243:
3241:
3237:
3231:
3228:
3227:
3225:
3223:
3219:
3212:
3209:
3208:
3206:
3204:
3200:
3197:
3193:
3187:
3186:Ritonavir (r)
3184:
3182:
3179:
3178:
3176:
3172:
3166:
3163:
3161:
3158:
3156:
3153:
3151:
3148:
3146:
3143:
3141:
3138:
3136:
3133:
3131:
3128:
3126:
3123:
3121:
3118:
3116:
3113:
3111:
3108:
3106:
3103:
3101:
3098:
3096:
3093:
3091:
3088:
3085:
3082:
3079:
3076:
3073:
3070:
3068:
3065:
3062:
3059:
3057:
3054:
3052:
3049:
3046:
3043:
3041:
3038:
3036:
3033:
3030:
3027:
3025:
3022:
3021:
3019:
3017:
3013:
2999:
2996:
2994:
2991:
2987:
2984:
2982:
2979:
2977:
2974:
2973:
2972:
2971:
2967:
2966:
2964:
2960:
2954:
2951:
2949:
2946:
2944:
2941:
2940:
2938:
2934:
2931:
2929:
2927:
2921:
2917:
2911:
2908:
2906:
2903:
2901:
2897:
2893:
2892:
2889:
2886:
2884:
2881:
2879:
2876:
2874:
2871:
2869:
2866:
2864:
2861:
2859:
2856:
2854:
2851:
2849:
2846:
2844:
2841:
2839:
2836:
2834:
2831:
2829:
2826:
2824:
2821:
2819:
2815:
2811:
2810:
2808:
2806:
2800:
2797:
2794:
2788:
2778:
2775:
2773:
2770:
2767:
2764:
2761:
2758:
2757:
2755:
2751:
2745:
2742:
2740:
2737:
2735:
2732:
2730:
2727:
2725:
2722:
2720:
2717:
2715:
2712:
2711:
2709:
2705:
2702:
2700:
2698:
2692:
2688:
2682:
2679:
2677:
2674:
2672:
2669:
2668:
2666:
2664:
2660:
2654:
2651:
2649:
2646:
2644:
2641:
2639:
2636:
2634:
2631:
2629:
2626:
2624:
2621:
2620:
2618:
2614:
2610:
2603:
2599:
2598:
2594:
2591:
2587:
2583:
2582:
2578:
2575:
2571:
2567:
2564:
2562:
2558:
2557:
2553:
2550:
2546:
2545:
2541:
2540:
2538:
2536:
2534:
2528:
2524:
2518:
2515:
2514:
2512:
2510:
2506:
2501:
2497:
2494:used against
2493:
2489:
2482:
2477:
2475:
2470:
2468:
2463:
2462:
2459:
2450:
2445:
2437:
2431:
2423:
2417:
2401:
2394:
2388:
2373:
2369:
2365:
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160:License data
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3503:recommended
3478:from market
3428:Lersivirine
3403:Capravirine
3342:Miltefosine
3327:Griffithsin
3322:Fosdevirine
2868:Censavudine
2498:(primarily
2339:. STAT News
2112:13 December
1949:16 February
1911:"Tenofovir"
1776:20 November
1270:15 November
1208:10665/44053
1111:12 December
897:vincristine
821:ganciclovir
777:Hepatitis C
664:hepatitis B
620:hepatitis B
616:hepatitis B
610:Hepatitis B
351:731772-45-5
336:Identifiers
146:MedlinePlus
119:Other names
110:Trade names
36:alafenamide
3555:Categories
3433:Lodenosine
3413:Droxinavir
3398:Brecanavir
3393:Atevirdine
3357:Seliciclib
3352:Scytovirin
3266:Elipovimab
3211:TRIM5alpha
2888:Stampidine
2793:inhibitors
2777:TMC-310911
2676:BMS-955176
2574:Leronlimab
2566:Vicriviroc
2320:29 October
2288:29 October
2255:31 October
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1928:23 October
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1356:30 October
1180:31 October
1020:22 October
991:10 October
960:References
893:lamivudine
731:Atazanavir
707:Didanosine
703:Tenofovir
342:CAS Number
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32:disoproxil
3488:Phase III
3476:Withdrawn
3453:Telinavir
3448:Palinavir
3443:Mozenavir
3423:Emivirine
3418:Lasinavir
3388:Aplaviroc
3317:Foscarnet
3297:Ceragenin
2858:Amdoxovir
2671:Bevirimat
2648:BI 224436
2107:Espacenet
1887:Drugs.com
1796:Drugs.com
1515:184485546
1499:0098-7484
1320:7 October
1295:7 October
1101:Drugs.com
1097:"Truvada"
981:Drugs.com
817:cidofovir
809:acyclovir
666:infection
555:adherence
497:pregnancy
478:safer sex
216:Routes of
190:Pregnancy
138:Monograph
132:Drugs.com
3533:Medicine
3438:Loviride
2406:4 August
2377:4 August
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540:Cochrane
482:by mouth
455:HIV/AIDS
430:(verify)
376:11954236
230:ATC code
223:By mouth
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192:category
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