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Butyrophenone

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Keith Parker; Laurence Brunton Goodman; Louis Sanford; Lazo, John S.; Gilman, Alfred (2006).
398: 745: 218: 55: 154: 8: 83: 73: 251: 176: 733: 585:. Some of these butyrophenones are used to treat various psychiatric disorders such as 698: 661: 690: 547: 412: 387: 329: 198: 729: 610: 502: 772: 681:
Grogan, Charles H.; Rice, Leonard M. (1967). "Ω-Azabicyclic Butyrophenones".
586: 376: 366: 165: 616: 702: 609:, the most potent commonly used antipsychotic (200 times more potent than 477: 619:, an atypical antipsychotic used for schizophrenia and bipolar depression 600: 590: 582: 578: 574: 490: 694: 463: 626: 622: 606: 470: 348: 145: 501:
Except where otherwise noted, data are given for materials in their
717: 436: 113: 106: 36: 603:, the most widely used classical antipsychotic drug in this class 185: 657:
Goodman & Gilman's The Pharmacological Basis of Therapeutics
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InChI=1S/C10H12O/c1-2-6-10(11)9-7-4-3-5-8-9/h3-5,7-8H,2,6H2,1H3
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InChI=1/C10H12O/c1-2-6-10(11)9-7-4-3-5-8-9/h3-5,7-8H,2,6H2,1H3
581:—forms the basis for many other chemicals containing various 96: 235: 596:
Examples of butyrophenone-derived pharmaceuticals include:
770: 649: 647: 645: 197: 452: 82: 753: 642: 760: 746: 680: 250: 175: 153: 217: 660:(11th ed.). New York: McGraw-Hill. 246: 771: 381:229 °C (444 °F; 502 K) 166: 495:99 °C (210 °F; 372 K) 278:Key: FFSAXUULYPJSKH-UHFFFAOYSA-N 133: 712: 371:12 °C (54 °F; 285 K) 288:Key: FFSAXUULYPJSKH-UHFFFAOYAC 188: 13: 448: 35: 26: 14: 800: 631:postoperative nausea and vomiting 716: 509: 505:(at 25 °C , 100 kPa). 683:Journal of Medicinal Chemistry 674: 569:The butyrophenone structure—a 1: 636: 566:. It is a colorless liquid. 732:. You can help Knowledge by 7: 22: 10: 805: 711: 353:148.20 g/mol 499: 430: 322: 297: 262: 66: 54: 49: 21: 589:, as well as acting as 459: 40: 31: 724:This article about a 458: 39: 30: 441:(fire diamond) 56:Preferred IUPAC name 695:10.1021/jm00316a022 388:Solubility in water 60:1-Phenylbutan-1-one 18: 550:with the formula C 532:Infobox references 460: 41: 32: 16: 741: 740: 540:Chemical compound 538: 537: 231:CompTox Dashboard 115:Interactive image 108:Interactive image 45: 44: 796: 784:Phenyl compounds 779:Aromatic ketones 762: 755: 748: 720: 713: 707: 706: 678: 672: 671: 651: 548:organic compound 522: 516: 513: 512: 480: 473: 466: 451: 413:Refractive index 330:Chemical formula 314:CCCC(=O)c1ccccc1 309:O=C(c1ccccc1)CCC 255: 254: 239: 237: 221: 201: 190: 179: 168: 157: 137: 117: 110: 86: 23: 19: 15: 804: 803: 799: 798: 797: 795: 794: 793: 769: 768: 767: 766: 710: 679: 675: 668: 652: 643: 639: 565: 561: 557: 553: 541: 534: 529: 528: 527:  ?) 518: 514: 510: 506: 485: 484: 483: 482: 475: 468: 461: 457: 449: 423: 421: 390: 342: 338: 332: 318: 315: 310: 305: 304: 293: 290: 289: 286: 280: 279: 276: 270: 269: 258: 240: 233: 224: 204: 191: 160: 140: 120: 100: 89: 76: 62: 61: 12: 11: 5: 802: 792: 791: 786: 781: 765: 764: 757: 750: 742: 739: 738: 721: 709: 708: 689:(4): 621–623. 673: 666: 640: 638: 635: 634: 633: 620: 614: 611:chlorpromazine 604: 563: 559: 555: 551: 539: 536: 535: 530: 508: 507: 503:standard state 500: 497: 496: 493: 487: 486: 476: 469: 462: 447: 446: 445: 444: 442: 433: 432: 428: 427: 424: 419: 411: 408: 407: 404: 395: 394: 391: 386: 383: 382: 379: 373: 372: 369: 363: 362: 359: 355: 354: 351: 345: 344: 340: 336: 333: 328: 325: 324: 320: 319: 317: 316: 313: 311: 308: 300: 299: 298: 295: 294: 292: 291: 287: 284: 283: 281: 277: 274: 273: 265: 264: 263: 260: 259: 257: 256: 243: 241: 229: 226: 225: 223: 222: 214: 212: 206: 205: 203: 202: 194: 192: 184: 181: 180: 170: 162: 161: 159: 158: 150: 148: 142: 141: 139: 138: 130: 128: 122: 121: 119: 118: 111: 103: 101: 94: 91: 90: 88: 87: 79: 77: 72: 69: 68: 64: 63: 59: 58: 52: 51: 47: 46: 43: 42: 33: 17:Butyrophenone 9: 6: 4: 3: 2: 801: 790: 787: 785: 782: 780: 777: 776: 774: 763: 758: 756: 751: 749: 744: 743: 737: 735: 731: 727: 722: 719: 715: 714: 704: 700: 696: 692: 688: 684: 677: 669: 663: 659: 658: 650: 648: 646: 641: 632: 628: 624: 621: 618: 615: 612: 608: 605: 602: 599: 598: 597: 594: 592: 588: 587:schizophrenia 584: 580: 576: 573:flanked by a 572: 567: 549: 545: 544:Butyrophenone 533: 526: 521: 504: 498: 494: 492: 489: 488: 481: 474: 467: 443: 440: 439: 435: 434: 429: 425: 418: 414: 410: 409: 405: 403: 402: 397: 396: 392: 389: 385: 384: 380: 378: 377:Boiling point 375: 374: 370: 368: 367:Melting point 365: 364: 361:clear liquid 360: 357: 356: 352: 350: 347: 346: 334: 331: 327: 326: 321: 312: 307: 306: 303: 296: 282: 272: 271: 268: 261: 253: 249: 248:DTXSID3047059 245: 244: 242: 232: 228: 227: 220: 216: 215: 213: 211: 208: 207: 200: 196: 195: 193: 187: 183: 182: 178: 174: 171: 169: 167:ECHA InfoCard 164: 163: 156: 152: 151: 149: 147: 144: 143: 136: 132: 131: 129: 127: 124: 123: 116: 112: 109: 105: 104: 102: 98: 93: 92: 85: 81: 80: 78: 75: 71: 70: 65: 57: 53: 48: 38: 34: 29: 25: 24: 20: 789:Ketone stubs 734:expanding it 723: 686: 682: 676: 655: 617:Lumateperone 595: 583:substituents 568: 543: 542: 437: 416: 400: 135:ChEMBL193524 67:Identifiers 601:Haloperidol 591:antiemetics 579:butyl chain 575:phenyl ring 491:Flash point 358:Appearance 323:Properties 173:100.007.091 773:Categories 667:0071422803 637:References 627:Antiemetic 623:Droperidol 607:Benperidol 349:Molar mass 219:186I11WB5B 146:ChemSpider 95:3D model ( 74:CAS Number 438:NFPA 704 431:Hazards 343:O 84:495-40-9 703:6037051 525:what is 523: ( 186:PubChem 726:ketone 701:  664:  577:and a 571:ketone 546:is an 520:verify 517:  426:1.520 302:SMILES 126:ChEMBL 50:Names 728:is a 558:C(O)C 406:2.77 393:poor 267:InChI 199:10315 97:JSmol 730:stub 699:PMID 662:ISBN 629:for 399:log 210:UNII 155:9893 691:doi 236:EPA 189:CID 775:: 697:. 687:10 685:. 644:^ 625:, 593:. 341:12 337:10 761:e 754:t 747:v 736:. 705:. 693:: 670:. 613:) 564:7 562:H 560:3 556:5 554:H 552:6 515:Y 479:1 472:1 465:1 422:) 420:D 417:n 415:( 401:P 339:H 335:C 238:) 234:( 99:)

Index



Preferred IUPAC name
CAS Number
495-40-9
JSmol
Interactive image
Interactive image
ChEMBL
ChEMBL193524
ChemSpider
9893
ECHA InfoCard
100.007.091
Edit this at Wikidata
PubChem
10315
UNII
186I11WB5B
CompTox Dashboard
DTXSID3047059
Edit this at Wikidata
InChI
SMILES
Chemical formula
Molar mass
Melting point
Boiling point
Solubility in water
log P

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