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The first plague vaccine was developed by bacteriologist ] in 1897.<ref name=":1"/><ref name=":0">{{Cite web|last=|first=|date=|title=WALDEMAR MORDECAI HAFFKINE|url=http://www.haffkineinstitute.org/waldemar.htm|access-date=2021-01-20|website=]|archive-date=2015-09-24|archive-url=https://web.archive.org/web/20150924024552/http://www.haffkineinstitute.org/waldemar.htm|url-status=dead}}</ref> He tested the vaccine on himself to prove that the vaccine was safe.<ref name=":0" /><ref>{{Cite journal|last=Yang|first=Wei|date=July 2010|title=|url=https://pubmed.ncbi.nlm.nih.gov/21122347/|journal=Zhonghua Yi Shi Za Zhi (Beijing, China: 1980)|volume=40|issue=4|pages=243–246|issn=0255-7053|pmid=21122347|via=}}</ref> Later, Haffkine conducted a massive inoculation program in ], and it is estimated that 26 million doses of
Haffkine's anti-plague vaccine were sent out from ] between 1897 and 1925, reducing the plague mortality by 50%-85%.<ref name=":1">{{Cite news|date=2020-12-11|title=Waldemar Haffkine: The vaccine pioneer the world forgot|language=en-GB|work=BBC News|url=https://www.bbc.com/news/world-asia-india-55050012|access-date=2021-01-20}}</ref><ref>{{Cite journal|last=Hawgood|first=Barbara J.|date=February 2007|title=Waldemar Mordecai Haffkine, CIE (1860-1930): prophylactic vaccination against cholera and bubonic plague in British India|url=https://pubmed.ncbi.nlm.nih.gov/17356724/|journal=Journal of Medical Biography|volume=15|issue=1|pages=9–19|doi=10.1258/j.jmb.2007.05-59|issn=0967-7720|pmid=17356724|s2cid=42075270|via=}}</ref>
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A systematic review by the ] found no studies of sufficient quality to be included in the review, and were thus unable to make any statement on the efficacy of modern vaccines.<ref>{{cite journal |vauthors=Jefferson T, Demicheli V, Pratt M |title=Vaccines for preventing plague |journal=Cochrane
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1623:| Zoonotic Infections |website=www.who.int |access-date=15 January 2022 |archive-url=https://web.archive.org/web/20060322051853/http://www.who.int/vaccine_research/diseases/zoonotic/en/index5.html |archive-date=22 March 2006 |url-status=dead}}
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1549:. There is strong evidence for the efficacy of administration of some plague vaccines in preventing or ameliorating the effects of a variety of clinical forms of ] by ]. Plague immunization also encompasses incurring state of
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1397:'' to prevent the ].<ref>{{MeshName|Plague+Vaccine}}</ref> ] have been used since 1890 but are less effective against the ], so live, ]s and ] have been developed to prevent the disease
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1598:. There is strong evidence for the efficacy of administration of some plague vaccines in preventing or ameliorating the effects of a variety of clinical forms of ] by
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Database Syst Rev |issue=2 |pages=CD000976 |year=2000 |volume=1998 |pmid=10796565 |doi=10.1002/14651858.CD000976|pmc=6532692 }}</ref>
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state of ''passive specific ]'' to plague in a susceptible organism after administration of a plague serum or plague
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an ]ic material (a ]) via a variety of routes to people at risk of contracting any clinical form of plague. This
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an ]ic material (a ]) via a variety of routes to people at risk of contracting any clinical form of
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in a susceptible organism after administration of a plague serum or plague
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in people with an immediate risk of developing the disease.<ref>
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A plague vaccine is used for an induction of ''active specific ]'' in
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126:Content added
118:
16:
1743:{{Vaccines}}
1736:{{Vaccines}}
1625:</ref>
1590:is known as
1571:</ref>
1545:is known as
1305:| DrugBank =
793:pregnancy_US
757:pregnancy_AU
744:<!-- A /
710:<!-- A /
609:| ATC_suffix
571:| ATC_prefix
557:| target = ]
534:| CAS_number
440:V0029287.jpg
1690:{{reflist}}
1683:{{reflist}}
1580:an organism
1529:susceptible
1278:| PubChem =
260:Rollbackers
235:Entranced98
1620:|title=WHO
1419:Attenuated
1361:attenuated
1068:= <!--
982:Schedule I
980:= <!--
890:= <!--
849:Schedule I
671:| DrugBank
594:attenuated
96:Revision 2
53:Revision 1
1433:September
1405:CO92ΔyopH
639:| PubChem
381:= vaccine
363:410667364
353:406373970
331:{{Drugbox
324:{{Drugbox
1780:⚫
1750:⚫
1531:organism
1401:vauthors
1298:⚫
1271:⚫
1255:⚫
1239:⚫
1179:⚫
1066:legal_UK
1041:Schedule
1027:<!--
1022:legal_US
978:legal_CA
956:or Class
938:<!--
933:legal_UK
888:legal_AU
847:<!--
842:legal_CA
797:B
784:⚫
746:B
696:⚫
664:⚫
632:⚫
602:⚫
585:⚫
564:⚫
550:⚫
527:⚫
513:⚫
489:⚫
466:| target
459:⚫
437:Wellcome
428:outbreak
413:injected
402:| image
371:⚫
245:contribs
180:contribs
170:CheMoBot
141:Wikitext
1541:. This
1449:__TOC__
1425:Vaccine
1367:vaccine
1035:Rx-only
434:bubonic
419:doctor,
305:Line 1:
302:Line 1:
265:153,961
192:141,565
1588:method
1525:'' in
1422:Plague
1412:Potent
1364:plague
1354:potent
1343:author
1098:-->
1057:-->
1044:I, II,
1011:-->
969:-->
922:-->
879:-->
612:= AK01
422:during
378:| type
134:Visual
82:Page 2
72:Page 2
39:Page 1
29:Page 1
1543:metod
1085:Class
574:= J07
410:being
267:edits
194:edits
1436:2006
1429:date
1415:Live
1375:2007
1371:year
1357:live
1347:CO92
1076:POM,
1070:GSL,
1009:VIII
877:VIII
501:live
241:talk
227:undo
222:edit
187:Bots
176:talk
162:edit
1596:'''
1592:'''
1560:to
1079:CD,
1047:III
1029:OTC
1005:VII
990:III
948:POM
940:GSL
873:VII
857:III
469:= ]
425:the
407:Man
283:Tag
1604:''
1600:''
1557:''
1417:,
1410:a
1408:Is
1393:''
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1352:a
1332:}}
1325:}}
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1073:P,
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1049:,
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998:V,
996:,
994:IV
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986:II
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952:CD
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892:S2
886:|
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869:VI
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861:IV
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855:,
853:II
851:,
840:|
791:|
773:B3
767:B2
761:B1
755:|
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724:B3
718:B2
712:B1
703:|
499:=
431:of
416:by
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1395:]
1373:=
1121:=
1096:C
1092:B
1088:A
1055:V
1038:/
1032:/
1024:=
967:C
963:B
959:A
944:P
935:=
865:V
844:=
820:=
770:/
764:/
741:=
721:/
715:/
707:=
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239:(
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