34:
218:
185:
172:, a clinical condition with acanthocytic red blood cells, neurologic problems and steatorrhea. This particular cause of acanthocytosis (also known as abetalipoproteinemia, apolipoprotein B deficiency, and Bassen-Kornzweig syndrome) is a rare, genetically inherited, autosomal recessive condition due to the inability to fully digest dietary fats in the intestines as a result of various mutations of the
236:
Acanthocytosis secondary to malnourishment, such as anorexia nervosa and cystic fibrosis, remits with resolution of the nutritional deficiency. Acanthocyte-like cells may be found in hypothyroidism, after splenectomy, and in myelodysplasia.
256:
due to elevated pH, blood storage, ATP depletion, calcium accumulation, and contact with glass. Acanthocytes should also be distinguished from keratocytes, also called 'horn cells' which have a few very large protuberances.
244:, which are also called 'burr cells', which although crenated are dissimilar in that they have multiple, small, projecting spiculations at regular intervals on the cell membrane. Burr cells usually imply
284:
206:
deficient lipoprotein accumulates in plasma causing increased cholesterol in RBCs. This causes abnormalities of membrane of RBC causing remodeling in spleen and formation of acanthocytes.
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168:
can refer generally to the presence of this type of crenated red blood cell, such as may be found in severe cirrhosis or pancreatitis, but can refer specifically to
248:, but are seen in many conditions, including mild hemolysis in hypomagnesemia and hypophosphatemia, hemolytic anemia in long-distance runners, and
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195:
Acanthocytes arise from either alterations in membrane lipids or structural proteins. Alterations in membrane lipids are seen in
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37:
Acanthocytes, from peripheral blood, under light microscopy. Note the irregularly shaped, non-circular cells in the image.
199:
and liver dysfunction. Alteration in membrane structural proteins are seen in neuroacanthocytosis and McLeod syndrome.
623:
150:
to acanthocytes, or may refer in some sources to a specific subset of 'extreme acanthocytes' that have undergone
457:
Mentzer WC. Spiculated cells (echinocytes and acanthocytes) and target cells. UpToDate (release: 20.12- C21.4)
266:
229:
The diagnosis of acanthocytosis should be differentiated from: acute or chronic anemia, hepatitis A, B, and C,
132:
904:
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20:
209:
In abetalipoproteinemia, there is deficiency of lipids and vitamin E causing abnormal morphology of RBCs.
363:
Rampoldi L, Danek A, Monaco AP (2002). "Clinical features and molecular bases of neuroacanthocytosis".
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502:. National Center for Biotechnology Information, U.S. National Library of Medicine.
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Hoffman, R; Benz, EJ; Silberstein, LE; Heslop, H; Weitz J; Anastasi, J. (2012).
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Longo, D; Fauci, AS; Kasper, DL; Hauser, SL; Jameson, JL; Loscalzo J. (2012).
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162:('spheroacanthocyte'), as seen in some patients with severe liver disease.
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316:"Decreased fluidity of red cell membrane lipids in abetalipoproteinemia"
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515:"Acanthocytosis: Practice Essentials, Pathophysiology, Epidemiology"
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99:, and several inherited neurological and other disorders such as
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151:
233:, hypopituitarism, malabsorption syndromes, and malnutrition.
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88:
75:
Acanthocytes have coarse, irregularly spaced, variably sized
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Hillman, RS; Ault, KA; Leporrier, M; Rinder, HM. (2011).
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loss has blunted the spicules and the cells have become
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Abnormal red blood cell with a spiked cell membrane
1018:Abnormal clinical and laboratory findings for RBCs
79:, resembling many-pointed stars. They are seen on
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558:
556:
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494:Haldeman-Englert, C; Zieve, D. (August 4, 2011).
1009:
425:
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314:Cooper RA, Durocher JR, Leslie MH (July 1977).
60:, due to thorny projections. A similar term is
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624:
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420:
631:
617:
471:Harrison's Principles of Internal Medicine
240:Acanthocytes should be distinguished from
601:at the U.S. National Library of Medicine
595:: Presented by the University of Virginia
567:Hematology: Basic Principles and Practice
339:
307:
212:
221:Acanthocytes compared to other forms of
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183:
174:microsomal triglyceride transfer protein
32:
638:
512:
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612:
453:
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48:, meaning 'thorn'), in biology and
13:
513:Alarcon, Pedro A de (2024-01-17).
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179:
64:. Often they may be confused with
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1034:
586:
188:Acanthocytosis in a patient with
154:modification whereby additional
52:, refers to an abnormal form of
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432:Hematology in Clinical Practice
302:Wrongdiagnosis / Acanthocytosis
543:de Alarcon PA (Nov 30, 2011).
487:
473:(18th ed.). McGraw-Hill.
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356:
295:
278:
267:List of hematologic conditions
1:
434:(5th ed.). McGraw-Hill.
304:Retrieved on October 12, 2009
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133:chronic granulomatous disease
290:Dorland's Medical Dictionary
252:. Burr cells can also arise
44:(from the Greek word ἄκανθα
21:Acanthocyte (disambiguation)
7:
496:"Bassen-Kornzweig syndrome"
260:
10:
1039:
569:(6th ed.). Elsevier.
250:pyruvate kinase deficiency
25:
18:
985:
930:Hypersegmented neutrophil
920:
890:
881:
851:
837:Hemoglobin precipitation
803:
777:
767:Hereditary stomatocytosis
713:Hereditary elliptocytosis
682:
656:
647:
377:10.1007/s00109-002-0349-z
962:Critical green inclusion
753:Sickle cell/drepanocyte
725:Hereditary spherocytosis
603:Medical Subject Headings
138:
26:Not to be confused with
694:Membrane abnormalities
864:Red cell agglutination
226:
213:Differential diagnoses
202:In liver dysfunction,
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115:, idiopathic neonatal
38:
220:
187:
93:chorea acanthocytosis
36:
967:Alder–Reilly anomaly
821:Basophilic stippling
231:hepatorenal syndrome
197:abetalipoproteinemia
190:abetalipoproteinemia
170:abetalipoproteinemia
85:abetalipoproteinemia
19:For other uses, see
942:Pelger–Huët anomaly
900:Reactive lymphocyte
826:Pappenheimer bodies
757:Sickle cell disease
204:apolipoprotein A-II
101:neuroacanthocytosis
790:Hypochromic anemia
519:Medscape Reference
227:
193:
56:that has a spiked
39:
1005:
1004:
1001:
1000:
957:Toxic vacuolation
952:Toxic granulation
883:White blood cells
877:
876:
816:Howell–Jolly body
576:978-1-4377-2928-3
441:978-0-07-162699-6
332:10.1172/JCI108747
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972:Jordans' anomaly
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805:Inclusion bodies
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545:"Acanthocytosis"
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480:978-0-07174889-6
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180:Pathophysiology
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166:Acanthocytosis
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129:Zieve syndrome
113:hypothyroidism
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285:"acanthocyte"
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58:cell membrane
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947:Döhle bodies
935:Arneth count
922:Granulocytes
785:Anisochromia
763:Stomatocyte
697:
674:Microcytosis
669:Macrocytosis
664:Anisocytosis
599:Acanthocytes
566:
522:. Retrieved
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410:. Retrieved
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148:synonymously
143:
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125:splenomegaly
109:pyknocytosis
107:, infantile
74:
70:schistocytes
61:
45:
41:
40:
905:Smudge cell
892:Lymphocytes
831:Cabot rings
744:Schistocyte
708:Elliptocyte
698:Acanthocyte
593:Acanthocyte
412:18 November
242:echinocytes
160:spherocytic
81:blood films
66:echinocytes
42:Acanthocyte
1012:Categories
977:Left shift
859:Haemoconia
841:Heinz body
739:Echinocyte
720:Spherocyte
640:Blood film
524:2024-06-26
273:References
146:may refer
144:Spur cells
121:alcoholism
77:crenations
62:spur cells
28:Acanthosis
749:Degmacyte
734:Dacrocyte
365:J Mol Med
117:hepatitis
91:disease,
993:Auer rod
869:Rouleaux
703:Codocyte
642:findings
393:21615621
385:12185448
261:See also
254:in vitro
50:medicine
152:splenic
46:acantha
778:Colour
605:(MeSH)
573:
477:
438:
391:
383:
350:874076
348:
341:372349
338:
246:uremia
131:, and
986:Other
852:Other
683:Shape
389:S2CID
139:Usage
89:liver
657:Size
571:ISBN
475:ISBN
436:ISBN
414:2012
381:PMID
346:PMID
373:doi
336:PMC
328:doi
287:at
83:in
68:or
1014::
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517:.
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369:80
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324:60
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632:e
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618:v
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375::
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330::
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30:.
23:.
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
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