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Alan Fersht

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the translation of the genetic code. Subsequently he was one of the pioneering founders of protein engineering, developing it as an analytical procedure for understanding interactions in proteins and enzyme catalysis. This radical new approach unravelled the relationships between the structure, activity and function of proteins. The full power of his methods became apparent in his seminal and far reaching contributions to the field of protein folding and stability. These studies opened the way to development of novel therapies in cancer and other diseases. He currently works on mutations that affect the stability and activity of the tumour suppressor p53 and how mutants may be "rescued" by small molecule drugs. His contributions have been widely recognised nationally and internationally by prizes for both chemistry and molecular biology, and by memberships of foreign academies.
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Herchel Smith Professor of Organic Chemistry at the MRC Centre for Protein Engineering, Cambridge, Sir Alan is one of the world's leading protein scientists. He was elected to the Royal Society in his late 30s in 1983 for his work illuminating enzymic catalysis and how enzymes attain high fidelity in
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of the transition. He elucidated the leaving-group specificity, leading to a detailed structural interpretation which showed the energetics of "strain" at the binding site. Another experiment dispelled final doubts about the role of a
1243: 2392: 348:, London. His father, Philip, was a ladies' tailor and his mother, Betty, a dressmaker. His grandparents were Jewish immigrants from Poland, Romania, Lithuania and Belarus. He was educated at 2422: 2417: 2412: 717: 907: 589:. He demonstrated that their precise specificity depends on consecutive independent recognition steps, and under appropriate conditions he trapped a transiently discharged 649: 727:
of The Royal Society, for his development and application of methods of protein engineering to provide descriptions of protein folding pathways at atomic resolution.
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Fersht, A.; Matouschek, A.; Serrano, L. (1992). "The folding of an enzyme I. Theory of protein engineering analysis of stability and pathway of protein folding".
2442: 157: 2071: 1724: 953: 1657: 867:(1993). "Engineered disulfide bonds as probes of the folding pathway of barnase: Increasing the stability of proteins against the rate of denaturation". 439:, which he developed as a primary method for analysis of the structure, activity and folding of proteins. He has developed methods for the resolution of 248: 1686: 313: 1166:
Fersht, A. R. (2024). "From covalent transition states in chemistry to noncovalent in biology: from β- to Φ-value analysis of protein folding".
593:. Fersht has shown how binding energy can be used to enhance either specificity or rate in an enzymatic reaction, leading to a demonstration of 1222: 2397: 781: 653: 1257: 842: 541: 296: 36: 1779: 1717: 681: 911: 2462: 2402: 1844: 1741: 1398: 1198: 1069: 537: 365: 325: 232: 794: 975: 1710: 665: 305: 2467: 2054: 1424: 693: 2457: 1583: 2447: 349: 429: 385: 216: 2432: 949: 707:
for his pioneering work on protein science. His citation on election to the Academy of Medical Sciences reads:
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from 1990 to 2010 when, on reaching the retirement age, he became an Emeritus Group Leader at the
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Structure and mechanism in protein science : a guide to enzyme catalysis and protein folding
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Fersht married Marilyn Persell in 1966 and has one son and one daughter. His recreations include
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Scientists sharing L1 in Caius Court, Gonville and Caius College, Cambridge, taken in 1994 (
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Structure and Mechanism in Protein Science: A Guide to Enzyme Catalysis and Protein Folding
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intermediate. More recently Fersht has studied a more complex group of enzymes, the
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for studying the folding transition states of proteins. His interests also include
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editor, ÖGV. (2015). Wilhelm Exner Medal. Austrian Trade Association. ÖGV. Austria.
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The selected papers of Sir Alan Fersht : development of protein engineering
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He has written an account of the history of Staunton and other chess sets.
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The Selected Papers of Sir Alan Fersht: Development of Protein Engineering
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at Cambridge from 1988 to 2010. He was the Director of the Cambridge
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Anniversary Prize; Novo Biotechnology Award; Charmian Medal of the
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in the sub-millisecond time-scale and has pioneered the method of
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Members of the University of Cambridge Department of Chemistry
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Alan Fersht is widely regarded as one of the main pioneers of
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Fellows of the Academy of Medical Sciences (United Kingdom)
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Fersht has received many prizes and medals including: the
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until 1972. Fersht was Wolfson Research Professor of the
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between active and inactive forms, and investigated the
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Members of the European Molecular Biology Organization
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Foreign associates of the National Academy of Sciences
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BBC: brief Fersht career summary at time of knighthood
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of the Protein Society; Natural Products Award of the
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Foreign Associate of the National Academy of Sciences
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limitations on mechanisms of the "induced fit" type.
1276:"Honorary doctorates – Uppsala University, Sweden" 1016: 520:. He is a Foreign Associate of the United States 508:(FRS) in 1983. The Royal Society awarded him the 404:from 1978 to 1988. He spent a sabbatical year at 376:Fersht spent a post-doctoral year (1968–1969) at 2438:Masters of Gonville and Caius College, Cambridge 2388:Fellows of Gonville and Caius College, Cambridge 2359: 1734:Masters of Gonville and Caius College, Cambridge 2383:Alumni of Gonville and Caius College, Cambridge 1489:Master of Gonville and Caius College, Cambridge 944: 942: 762: 760: 1260:. National Academy of Sciences. Archived from 656:; Jubilee Lecture and the Harden Medal of the 2048: 1718: 910:. Academy of Medical Sciences. Archived from 556:methods. He showed that a slow relaxation of 332:, and is sometimes described as a founder of 2443:People educated at Sir George Monoux College 1388: 1099:Intramolecular Catalysis of Ester Hydrolysis 939: 859: 757: 654:Federation of European Biochemical Societies 249:Intramolecular Catalysis of Ester Hydrolysis 1417:Jaques and British Chess Company Chess Sets 1414: 1328:"Alan Fersht. 2001 Stein and Moore Award". 1242:. London: The Royal Society. Archived from 512:in 1991 for molecular biology, in 1998 the 339: 2055: 2041: 1725: 1711: 1221:: CS1 maint: location missing publisher ( 1059: 1010: 1008: 1006: 1004: 1002: 1000: 408:on an Eleanor Roosevelt Fellowship of the 45: 902: 900: 898: 542:Fellow of the Academy of Medical Sciences 400:and Professor of Biological Chemistry at 1234: 1232: 796:Studies of disulphide mutants of barnase 715: 682:Bijvoet Center for Biomolecular Research 548:Distinguished for work on mechanisms of 475: 454: 1357: 1295:Angewandte Chemie International Edition 1031: ed.). A & C Black. 997: 908:"Professor Sir Alan Fersht FRS FMedSci" 803:(PhD thesis). University of Cambridge. 2360: 1188: 1165: 1102:(PhD thesis). University of Cambridge. 1092: 895: 792: 786: 680:Prize and Medal; Bijvoet Medal of the 601:Fersht holds honorary doctorates from 371: 2036: 1706: 1382: 1293:/ Breslow Award to Peter B. Dervan". 1229: 835: 538:American Academy of Arts and Sciences 471: 366:Gonville and Caius College, Cambridge 326:Gonville and Caius College, Cambridge 233:Gonville and Caius College, Cambridge 2398:Academics of Imperial College London 1391:Jaques Staunton Chess Sets 1849–1939 1120:. London. 22 March 1965. p. 12. 1060:Fersht, Alan; Wang, Qinghua (2010). 1014: 621:(2008). He is an Honorary Fellow of 536:, an Honorary Foreign Member of the 344:Fersht was born on 21 April 1943 in 1250: 1086: 1037:10.1093/ww/9780199540884.013.U15668 306:MRC Laboratory of Molecular Biology 13: 1064:. London: Imperial College Press. 956:from the original on 22 April 2015 775: 723:In August 2020 he was awarded the 694:University of California, Berkeley 300:(born 21 April 1943) is a British 14: 2479: 1437: 843:"Women at Cambridge: Jane Clarke" 1444: 1116:"Sweeping Chess Win by Oxford". 730: 664:Biotechnology Winter Symposium; 350:Sir George Monoux Grammar School 84:Sir George Monoux Grammar School 1407: 1348: 1321: 1282: 1268: 1182: 1168:Quarterly Reviews of Biophysics 1109: 986: 650:The Datta Lectureship and Medal 560:was not a chemical step on the 430:Laboratory of Molecular Biology 386:Laboratory of Molecular Biology 328:from 2012 to 2018. He works on 217:Laboratory of Molecular Biology 122: 2463:Recipients of the Copley Medal 1240:"EC/1983/09: Fersht, Alan Roy" 968: 918: 853: 615:Hebrew University of Jerusalem 526:American Philosophical Society 516:for chemistry and in 2008 the 426:Centre for Protein Engineering 1: 2101:Sivaramakrishna Chandrasekhar 750: 611:Weizmann Institute of Science 2403:Fellows of the Royal Society 1145:10.1016/0022-2836(92)90561-W 1133:Journal of Molecular Biology 1044:UK public library membership 552:, especially by stopped and 522:National Academy of Sciences 364:to read Natural Sciences at 7: 666:Christian B. Anfinsen Award 506:Fellow of the Royal Society 16:British chemist (born 1943) 10: 2484: 2133:William Alexander Gambling 1845:Gonville and Caius College 678:Kaj Ulrik Linderstrøm-Lang 670:Royal Society of Chemistry 638:Royal Society of Chemistry 607:Vrije Universiteit Brussel 587:aminoacyl tRNA synthetases 528:, a Foreign Member of the 524:, a Foreign Member of the 2468:Jewish British scientists 2314: 2293: 2078: 1843: 1740: 1691: 1683: 1673: 1646: 1638: 1628: 1620: 1610: 1602: 1592: 1572: 1564: 1554: 1545: 1537: 1527: 1518: 1510: 1505: 1495: 1486: 1478: 1473: 674:American Chemical Society 623:Darwin College, Cambridge 282: 259: 241: 209: 185: 178: 132: 109: 99: 89: 79: 53: 44: 23: 2458:Bijvoet Medal recipients 1588:Robert E. M. Hedges 1018:"Fersht, Sir Alan (Roy)" 769:publications indexed by 627:Jesus College, Cambridge 486:Samuel Frederick Edwards 394:Jesus College, Cambridge 388:until 1977 and a junior 340:Early life and education 2448:People from Walthamstow 1419:. Kaissa Publications. 1393:. Kaissa Publications. 1105:(subscription required) 1029:Oxford University Press 782:Alan Fersht LMB Profile 410:American Cancer Society 402:Imperial College London 318:University of Cambridge 314:Department of Chemistry 222:University of Cambridge 94:University of Cambridge 2123:Malcolm Ferguson-Smith 1955:Ernest Stewart Roberts 1949:Norman Macleod Ferrers 1925:Richard Fisher Belward 1632:C. N. R. Rao 1307:10.1002/anie.200462026 720: 714: 599: 501: 451:, disease and cancer. 416:(1978–79). Fersht was 2433:English biophysicists 2347:Frank Westheimer 1389:Fersht, Alan (2007). 1189:Fersht, Alan (2017). 793:Clarke, Jane (1993). 719: 709: 546: 504:Fersht was elected a 479: 455:Selected publications 2329:G. Evelyn Hutchinson 2323:Anatole Abragam 2220:Michael J. D. Powell 2106:Pierre Deslongchamps 1415:Alan Fersht (2010). 745:wildlife photography 530:Accademia dei Lincei 308:, Cambridge, and an 2428:Royal Medal winners 1979:Nevill Francis Mott 1967:John Forbes Cameron 1865:William Branthwaite 1649:Wilhelm Exner Medal 1558:Malcolm H. Chisholm 1482:Sir Christopher Hum 881:10.1021/bi00067a022 823:on 22 December 2018 698:Wilhelm Exner Medal 658:Biochemical Society 437:protein engineering 406:Stanford University 378:Brandeis University 372:Career and research 334:protein engineering 289:Sir Alan Roy Fersht 2341:Henry Stommel 2301:David Attenborough 2168:Christopher Hooley 1961:Hugh Kerr Anderson 1301:(41): 5430. 2004. 1246:on 9 January 2016. 817:uk.bl.ethos.318014 721: 686:Utrecht University 646:Harvard University 644:Lecture and Prize 603:Uppsala University 502: 500:, and Alan Fersht) 472:Awards and honours 449:protein misfolding 445:phi value analysis 356:grammar school in 277:Andreas Matouschek 2355: 2354: 2306:Margaret Thatcher 2275:Charles Weissmann 2158:Richard Henderson 2030: 2029: 1877:Thomas Batchcroft 1816:William Buckenham 1768:William Somersham 1701: 1700: 1692:Succeeded by 1674:Succeeded by 1658:Christian Wandrey 1629:Succeeded by 1611:Succeeded by 1593:Succeeded by 1555:Succeeded by 1531:Charles Weissmann 1528:Succeeded by 1496:Succeeded by 1474:Academic offices 1400:978-0-9557325-0-8 1369:The Royal Society 1264:on 17 April 2015. 1200:978-981-322-519-0 1071:978-1-84816-554-0 1042:(Subscription or 914:on 17 April 2015. 849:on 24 March 2015. 619:Aarhus University 534:Academia Europaea 422:Organic Chemistry 362:State Scholarship 312:Professor in the 286: 285: 273:Sophie E. Jackson 260:Doctoral students 180:Scientific career 2475: 2408:Knights Bachelor 2378:British chemists 2057: 2050: 2043: 2034: 2033: 1937:Benedict Chapman 1727: 1720: 1713: 1704: 1703: 1684:Preceded by 1677:Bertil Andersson 1670: 1642:Zdeněk P. Bažant 1639:Preceded by 1621:Preceded by 1603:Preceded by 1584:Sir Philip Cohen 1565:Preceded by 1538:Preceded by 1511:Preceded by 1479:Preceded by 1471: 1470: 1448: 1447: 1431: 1430: 1411: 1405: 1404: 1386: 1380: 1379: 1377: 1375: 1361: 1355: 1352: 1346: 1345: 1336:(4): 905. 2001. 1325: 1319: 1318: 1286: 1280: 1279: 1272: 1266: 1265: 1254: 1248: 1247: 1236: 1227: 1226: 1220: 1212: 1186: 1180: 1179: 1163: 1157: 1156: 1128: 1122: 1121: 1113: 1107: 1106: 1103: 1094:Fersht, Alan Roy 1090: 1084: 1083: 1057: 1048: 1047: 1040: 1020: 1012: 995: 990: 984: 983: 982:on 27 June 2009. 978:. Archived from 972: 966: 965: 963: 961: 946: 937: 936: 934: 932: 922: 916: 915: 904: 893: 892: 857: 851: 850: 839: 833: 832: 830: 828: 819:. Archived from 790: 784: 779: 773: 764: 690:Gilbert N. Lewis 688:in 2008 and the 562:reaction pathway 550:enzyme catalysis 299: 255: 227:Imperial College 126: 124: 71: 67: 65: 49: 39: 21: 20: 2483: 2482: 2478: 2477: 2476: 2474: 2473: 2472: 2453:Jewish chemists 2358: 2357: 2356: 2351: 2335:Jean Leray 2310: 2289: 2285:Dudley Williams 2195:C David Marsden 2138:Ian Graham Gass 2112:William Douglas 2091:Patrick Bateson 2074: 2061: 2031: 2026: 2009:Christopher Hum 2003:Neil McKendrick 1839: 1798:Henry Costessey 1792:Edmund Sheriffe 1774:John Rickingale 1756:William Rougham 1736: 1731: 1697: 1689: 1679: 1660: 1654: 1652: 1644: 1634: 1626: 1616: 1608: 1598: 1580: 1578: 1570: 1560: 1551: 1543: 1541:Jean-Marie Lehn 1533: 1524: 1516: 1501: 1492: 1484: 1469: 1468: 1467: 1449: 1445: 1440: 1435: 1434: 1427: 1412: 1408: 1401: 1387: 1383: 1373: 1371: 1363: 1362: 1358: 1353: 1349: 1330:Protein Science 1327: 1326: 1322: 1288: 1287: 1283: 1274: 1273: 1269: 1256: 1255: 1251: 1238: 1237: 1230: 1214: 1213: 1201: 1187: 1183: 1164: 1160: 1129: 1125: 1115: 1114: 1110: 1104: 1091: 1087: 1072: 1058: 1051: 1041: 1013: 998: 991: 987: 974: 973: 969: 959: 957: 948: 947: 940: 930: 928: 924: 923: 919: 906: 905: 896: 858: 854: 841: 840: 836: 826: 824: 791: 787: 780: 776: 765: 758: 753: 733: 703:In 2003 he was 494:David Shoenberg 474: 457: 441:protein folding 414:Arthur Kornberg 390:research fellow 374: 342: 330:protein folding 291: 271: 253: 237: 205: 193:Protein folding 174: 140:Knight Bachelor 128: 125: 1966) 120: 116: 115:Marilyn Persell 104:Protein folding 90:Alma mater 75: 74:London, England 72: 69: 63: 61: 60: 59: 58:Alan Roy Fersht 40: 31: 29: 26: 17: 12: 11: 5: 2481: 2471: 2470: 2465: 2460: 2455: 2450: 2445: 2440: 2435: 2430: 2425: 2420: 2415: 2410: 2405: 2400: 2395: 2390: 2385: 2380: 2375: 2370: 2353: 2352: 2350: 2349: 2343: 2337: 2331: 2325: 2318: 2316: 2312: 2311: 2309: 2308: 2303: 2297: 2295: 2291: 2290: 2288: 2287: 2282: 2277: 2272: 2270:Felix Weinberg 2267: 2262: 2257: 2255:Brian Spalding 2252: 2250:Edwin Southern 2247: 2242: 2237: 2232: 2227: 2222: 2217: 2215:Michael Pepper 2212: 2207: 2202: 2200:Donald Metcalf 2197: 2192: 2190:George Lusztig 2187: 2182: 2180:Peter Lawrence 2177: 2170: 2165: 2160: 2155: 2150: 2145: 2140: 2135: 2130: 2125: 2120: 2115: 2108: 2103: 2098: 2096:Edward Cocking 2093: 2088: 2082: 2080: 2076: 2075: 2060: 2059: 2052: 2045: 2037: 2028: 2027: 2025: 2024: 2021:Pippa Rogerson 2018: 2012: 2006: 2000: 1994: 1988: 1985:Joseph Needham 1982: 1976: 1973:James Chadwick 1970: 1964: 1958: 1952: 1946: 1940: 1934: 1928: 1922: 1916: 1913:James Burrough 1910: 1904: 1898: 1892: 1886: 1880: 1874: 1868: 1862: 1856: 1849: 1847: 1841: 1840: 1838: 1837: 1831: 1825: 1819: 1813: 1807: 1801: 1795: 1789: 1783: 1780:Thomas Attwood 1777: 1771: 1765: 1762:Richard Pulham 1759: 1753: 1746: 1744: 1738: 1737: 1730: 1729: 1722: 1715: 1707: 1699: 1698: 1693: 1690: 1687:Wolfgang Knoll 1685: 1681: 1680: 1675: 1672: 1645: 1640: 1636: 1635: 1630: 1627: 1622: 1618: 1617: 1612: 1609: 1604: 1600: 1599: 1594: 1591: 1571: 1566: 1562: 1561: 1556: 1553: 1544: 1539: 1535: 1534: 1529: 1526: 1517: 1512: 1508: 1507: 1503: 1502: 1499:Pippa Rogerson 1497: 1494: 1485: 1480: 1476: 1475: 1450: 1443: 1442: 1441: 1439: 1438:External links 1436: 1433: 1432: 1426:979-8800208528 1425: 1406: 1399: 1381: 1356: 1347: 1320: 1281: 1267: 1249: 1228: 1199: 1193:. New Jersey. 1181: 1158: 1139:(3): 771–782. 1123: 1108: 1085: 1070: 1049: 996: 985: 967: 938: 917: 894: 875:(16): 4322–9. 852: 834: 785: 774: 771:Google Scholar 755: 754: 752: 749: 732: 729: 591:aminoacyl tRNA 473: 470: 469: 468: 463: 456: 453: 382:William Jencks 380:working under 373: 370: 341: 338: 284: 283: 280: 279: 270: 269: 263: 261: 257: 256: 245: 239: 238: 236: 235: 230: 224: 219: 213: 211: 207: 206: 204: 203: 200: 195: 189: 187: 183: 182: 176: 175: 173: 172: 166: 160: 155: 149: 143: 136: 134: 130: 129: 118: 114: 113: 111: 107: 106: 101: 100:Known for 97: 96: 91: 87: 86: 81: 77: 76: 73: 57: 55: 51: 50: 42: 41: 30: 27: 24: 15: 9: 6: 4: 3: 2: 2480: 2469: 2466: 2464: 2461: 2459: 2456: 2454: 2451: 2449: 2446: 2444: 2441: 2439: 2436: 2434: 2431: 2429: 2426: 2424: 2421: 2419: 2416: 2414: 2411: 2409: 2406: 2404: 2401: 2399: 2396: 2394: 2391: 2389: 2386: 2384: 2381: 2379: 2376: 2374: 2373:Living people 2371: 2369: 2366: 2365: 2363: 2348: 2344: 2342: 2338: 2336: 2332: 2330: 2326: 2324: 2320: 2319: 2317: 2313: 2307: 2304: 2302: 2299: 2298: 2296: 2292: 2286: 2283: 2281: 2280:John Westcott 2278: 2276: 2273: 2271: 2268: 2266: 2263: 2261: 2258: 2256: 2253: 2251: 2248: 2246: 2243: 2241: 2240:Dennis Sciama 2238: 2236: 2235:Alan Sargeson 2233: 2231: 2228: 2226: 2225:Philip Randle 2223: 2221: 2218: 2216: 2213: 2211: 2208: 2206: 2205:Keith O'Nions 2203: 2201: 2198: 2196: 2193: 2191: 2188: 2186: 2183: 2181: 2178: 2176: 2175: 2174:Anthony James 2171: 2169: 2166: 2164: 2161: 2159: 2156: 2154: 2151: 2149: 2146: 2144: 2141: 2139: 2136: 2134: 2131: 2129: 2126: 2124: 2121: 2119: 2118:R. John Ellis 2116: 2114: 2113: 2109: 2107: 2104: 2102: 2099: 2097: 2094: 2092: 2089: 2087: 2086:Martin Aitken 2084: 2083: 2081: 2077: 2073: 2069: 2068:Royal Society 2065: 2058: 2053: 2051: 2046: 2044: 2039: 2038: 2035: 2022: 2019: 2016: 2013: 2010: 2007: 2004: 2001: 1998: 1995: 1992: 1989: 1986: 1983: 1980: 1977: 1974: 1971: 1968: 1965: 1962: 1959: 1956: 1953: 1950: 1947: 1944: 1941: 1938: 1935: 1932: 1929: 1926: 1923: 1920: 1917: 1914: 1911: 1908: 1905: 1902: 1899: 1896: 1893: 1890: 1887: 1884: 1881: 1878: 1875: 1872: 1869: 1866: 1863: 1860: 1857: 1854: 1851: 1850: 1848: 1846: 1842: 1835: 1832: 1829: 1826: 1823: 1820: 1817: 1814: 1811: 1808: 1805: 1802: 1799: 1796: 1793: 1790: 1787: 1786:Thomas Boleyn 1784: 1781: 1778: 1775: 1772: 1769: 1766: 1763: 1760: 1757: 1754: 1751: 1748: 1747: 1745: 1743: 1742:Gonville Hall 1739: 1735: 1728: 1723: 1721: 1716: 1714: 1709: 1708: 1705: 1696: 1688: 1682: 1678: 1671: 1668: 1664: 1659: 1651: 1650: 1643: 1637: 1633: 1625: 1624:Tomas Lindahl 1619: 1615: 1607: 1601: 1597: 1590: 1589: 1585: 1577: 1576: 1569: 1563: 1559: 1550: 1549: 1542: 1536: 1532: 1523: 1522: 1515: 1514:Noreen Murray 1509: 1504: 1500: 1491: 1490: 1483: 1477: 1472: 1465: 1464: 1463: 1457: 1453: 1428: 1422: 1418: 1410: 1402: 1396: 1392: 1385: 1370: 1366: 1360: 1351: 1343: 1339: 1335: 1331: 1324: 1316: 1312: 1308: 1304: 1300: 1296: 1292: 1285: 1277: 1271: 1263: 1259: 1253: 1245: 1241: 1235: 1233: 1224: 1218: 1210: 1206: 1202: 1196: 1192: 1185: 1177: 1173: 1169: 1162: 1154: 1150: 1146: 1142: 1138: 1134: 1127: 1119: 1112: 1101: 1100: 1095: 1089: 1081: 1077: 1073: 1067: 1063: 1056: 1054: 1045: 1038: 1034: 1030: 1026: 1025: 1019: 1015:Anon (2020). 1011: 1009: 1007: 1005: 1003: 1001: 994: 989: 981: 977: 971: 955: 951: 945: 943: 927: 921: 913: 909: 903: 901: 899: 890: 886: 882: 878: 874: 870: 866: 865:Fersht, A. R. 862: 856: 848: 844: 838: 822: 818: 814: 810: 806: 802: 798: 797: 789: 783: 778: 772: 768: 763: 761: 756: 748: 746: 742: 738: 731:Personal life 728: 726: 718: 713: 708: 706: 701: 699: 695: 691: 687: 683: 679: 675: 671: 667: 663: 659: 655: 651: 647: 643: 639: 635: 630: 628: 624: 620: 616: 612: 608: 604: 598: 596: 595:thermodynamic 592: 588: 584: 579: 575: 571: 570:isomerisation 567: 563: 559: 555: 554:quenched flow 551: 545: 543: 539: 535: 531: 527: 523: 519: 515: 511: 507: 499: 495: 491: 487: 483: 478: 467: 464: 462: 459: 458: 452: 450: 446: 442: 438: 433: 431: 427: 423: 420:Professor of 419: 418:Herchel Smith 415: 411: 407: 403: 399: 398:Royal Society 395: 391: 387: 383: 379: 369: 367: 363: 359: 355: 351: 347: 337: 335: 331: 327: 323: 319: 315: 311: 307: 303: 298: 294: 290: 281: 278: 274: 268: 265: 264: 262: 258: 251: 250: 246: 244: 240: 234: 231: 228: 225: 223: 220: 218: 215: 214: 212: 208: 201: 199: 196: 194: 191: 190: 188: 184: 181: 177: 170: 167: 164: 161: 159: 156: 153: 150: 147: 144: 141: 138: 137: 135: 131: 112: 108: 105: 102: 98: 95: 92: 88: 85: 82: 78: 70:(age 81) 68:21 April 1943 56: 52: 48: 43: 38: 34: 22: 19: 2172: 2153:Ray Guillery 2127: 2110: 2014: 1991:William Wade 1907:Thomas Gooch 1895:James Halman 1889:Robert Brady 1883:William Dell 1879:(1626, 1660) 1871:John Gostlin 1859:Thomas Legge 1834:Thomas Bacon 1828:John Styrmin 1810:Edmund Stubb 1656: 1653:2009 1647: 1606:Cyril Hilsum 1596:Chris Dobson 1582: 1579:2008 1573: 1546: 1519: 1487: 1460: 1459: 1458:profile for 1455: 1416: 1409: 1390: 1384: 1372:. Retrieved 1368: 1359: 1350: 1333: 1329: 1323: 1298: 1294: 1290: 1284: 1270: 1262:the original 1252: 1244:the original 1190: 1184: 1167: 1161: 1136: 1132: 1126: 1117: 1111: 1098: 1093: 1088: 1061: 1022: 988: 980:the original 970: 958:. Retrieved 929:. Retrieved 920: 912:the original 872: 869:Biochemistry 868: 864: 855: 847:the original 837: 825:. Retrieved 821:the original 800: 795: 788: 777: 734: 725:Copley Medal 722: 710: 702: 631: 617:(2006), and 600: 558:chymotrypsin 547: 532:, Member of 503: 465: 460: 434: 375: 343: 288: 287: 247: 210:Institutions 179: 169:Copley Medal 18: 2368:1943 births 2260:Nigel Unwin 2245:Ian Sneddon 2185:John Lawson 2163:Peter Higgs 2148:George Gray 2143:Ian Gibbons 2128:Alan Fersht 2015:Alan Fersht 1943:Edwin Guest 1931:Martin Davy 1750:John Colton 1661: [ 1575:Royal Medal 1521:Gabor Medal 1462:Alan Fersht 960:21 November 767:Alan Fersht 642:Max Tishler 625:(2014) and 583:tetrahedral 568:-dependent 518:Royal Medal 510:Gabor Medal 498:Rodney Hill 490:David Tabor 482:Nevill Mott 358:Walthamstow 267:Jane Clarke 163:Royal Medal 146:Gabor Medal 28:Alan Fersht 2362:Categories 2294:Statute 12 2230:Ivan Roitt 1997:Peter Gray 1919:John Smith 1901:John Ellys 1853:John Caius 1822:John Skypp 1804:John Barly 1695:Ada Yonath 1614:Ron Laskey 1548:Davy Medal 1493:2012–2018 1170:. 57 e4. 1046:required.) 801:jisc.ac.uk 751:References 696:, and the 578:equilibria 574:energetics 514:Davy Medal 152:Davy Medal 64:1943-04-21 2210:Ted Paige 1568:Jim Feast 1217:cite book 1209:986523773 1118:The Times 1080:646400491 1024:Who's Who 861:Clarke, J 700:in 2009. 320:. He was 80:Education 2265:Ian Ward 2070:elected 1374:9 August 1342:11345067 1315:15484254 1176:38597675 1096:(1968). 1027:(online 954:Archived 809:53666398 741:horology 705:knighted 629:(2017). 613:(2004), 609:(1999), 605:(1999), 564:, but a 354:all-boys 310:Emeritus 229:, London 2315:Foreign 2079:Fellows 2072:in 1983 2066:of the 2064:Fellows 1506:Awards 1454:has an 1452:Scholia 1153:1569556 931:26 July 889:8476861 827:17 June 652:of the 346:Hackney 316:at the 304:at the 302:chemist 297:FMedSci 127:​ 119:​ 37:FMedSci 2345:  2339:  2333:  2327:  2321:  2023:(2018) 2017:(2012) 2011:(2006) 2005:(1996) 1999:(1988) 1993:(1976) 1987:(1966) 1981:(1959) 1975:(1948) 1969:(1928) 1963:(1912) 1957:(1903) 1951:(1880) 1945:(1852) 1939:(1839) 1933:(1803) 1927:(1795) 1921:(1764) 1915:(1754) 1909:(1716) 1903:(1703) 1897:(1700) 1891:(1660) 1885:(1649) 1873:(1619) 1867:(1607) 1861:(1573) 1855:(1559) 1836:(1552) 1830:(1540) 1824:(1536) 1818:(1513) 1812:(1504) 1806:(1483) 1800:(1475) 1794:(1472) 1788:(1454) 1782:(1426) 1776:(1416) 1770:(1412) 1764:(1393) 1758:(1360) 1752:(1349) 1655:With: 1581:With: 1456:author 1423:  1397:  1340:  1313:  1291:Millan 1207:  1197:  1174:  1151:  1078:  1068:  887:  815:  807:  692:Medal 662:Nature 540:and a 322:Master 254:(1968) 252:  243:Thesis 202:Cancer 186:Fields 171:(2020) 165:(2008) 154:(1998) 148:(1991) 142:(2003) 133:Awards 110:Spouse 1669:] 1552:1998 1525:1991 813:EThOS 737:chess 412:with 352:, an 295: 121:( 117: 35: 1586:and 1421:ISBN 1395:ISBN 1376:2020 1338:PMID 1311:PMID 1223:link 1205:OCLC 1195:ISBN 1172:PMID 1149:PMID 1076:OCLC 1066:ISBN 962:2012 933:2011 885:PMID 829:2019 805:OCLC 743:and 634:FEBS 576:and 54:Born 1303:doi 1141:doi 1137:224 1033:doi 877:doi 684:of 392:at 324:of 293:FRS 198:p53 33:FRS 25:Sir 2364:: 1667:pt 1665:; 1663:de 1367:. 1334:10 1332:. 1309:. 1299:43 1297:. 1231:^ 1219:}} 1215:{{ 1203:. 1147:. 1135:. 1074:. 1052:^ 1021:. 999:^ 952:. 941:^ 897:^ 883:. 873:32 871:. 863:; 811:. 799:. 759:^ 747:. 739:, 676:; 648:; 640:; 566:pH 496:, 492:, 488:, 484:, 336:. 275:, 123:m. 66:) 2056:e 2049:t 2042:v 1726:e 1719:t 1712:v 1466:. 1429:. 1403:. 1378:. 1344:. 1317:. 1305:: 1278:. 1225:) 1211:. 1178:. 1155:. 1143:: 1082:. 1039:. 1035:: 964:. 935:. 891:. 879:: 831:. 62:(

Index

FRS
FMedSci

Sir George Monoux Grammar School
University of Cambridge
Protein folding
Knight Bachelor
Gabor Medal
Davy Medal
Foreign Associate of the National Academy of Sciences
Royal Medal
Copley Medal
Protein folding
p53
Laboratory of Molecular Biology
University of Cambridge
Imperial College
Gonville and Caius College, Cambridge
Thesis
Intramolecular Catalysis of Ester Hydrolysis
Jane Clarke
Sophie E. Jackson
Andreas Matouschek
FRS
FMedSci
chemist
MRC Laboratory of Molecular Biology
Emeritus
Department of Chemistry
University of Cambridge

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