6940:
6874:
6912:
7658:
7125:
6939:
8770:
of
Gottingen was sponsored by a German pharmaceutical firm. In 1929, both terms announced the isolation of a pure crystal female sex hormone, estrone, in 1929, although Doisy and Allen did so two months earlier than Butenandt.27 By 1931, estrone was being commercially produced by Parke Davis in this country, and Schering-Kahlbaum in Germany. Interestingly, when Butenandt (who shared the Nobel Prize for chemistry in 1939) isolated estrone and analyzed its structure, he found that it was a steroid, the first hormone to be classed in this molecular family.
7700:
7363:
8081:
Estrugenone, Estrusol, Femestrone, Femidyn, Folikrin, Folipex, Folisan, Folliculin, Follicunodis, Follidrin, Gineburno, Glandubolin, Grietalgen, Grietalgen
Hidrocort, Gynogen, Hiestrone, Hormofollin, Hormonin, Hormovarine, Kestrin, Kestrone, Ketodestrin, Kolpon, Ladies Pearl, Livifolin, Menagen, Metharmon-F, Neo-Estrone, Oestrilin, Oestrin, Oestroform, Oestroperos, Ovex, Ovifollin, Perlatan, Progynon, Senikolp, Solliculin, Solutio Folliculinum, Synergon (in combination with
6911:
6873:
58:
49:
7047:
Estrone in oil solution by intramuscular injection has a shorter duration than estrone in aqueous suspension by intramuscular injection. Estrone in oil solution by intramuscular injection is rapidly absorbed, while estrone in aqueous suspension has a prolonged period of absorption. Upon intramuscular
1176:
of estrone at the ERα and ERβ were 2.6% and 4.3% of those of estradiol, respectively. In accordance, the estrogenic activity of estrone has been reported to be approximately 4% of that of estradiol. Other studies have reported that estrone has about one-tenth of the potency of estradiol in activating
8769:
When Allen and Doisy heard about the , they realized there was a rich and easily handled source of hormones in urine from which they could develop a potent extract. Allen and Doisy's research was sponsored by the committee, while that of their main rival, Adolt
Butenandt (b. 1903) of the University
7535:
of estrone is 1,050 L/day/m and of estradiol is 580 L/day/m, while that of estrone sulfate is 80 L/day/m. For comparison, the metabolic clearance rate of estriol is 1,110 L/day/m. A single 1 to 2 mg dose of estrone in oil solution by intramuscular injection has a duration of
9054:
The following are dosages for parenteral : Estrone. For vasomotor symptoms or atrophic vaginitis, 0.1 to 0.5 mg is given 2 or 3 times weekly. For female hypogonadism, castration, or primary ovarian failure, 0.1 to 1.0 mg is given weekly in single or divided doses. Further dosage adjusted according
10902:
ESTRONE Parenteral Dosage Forms ESTRONE INJECTABLE SUSPENSION USP Usual adult dose
Atrophic vaginitis or Menopausal (vasomotor) symptoms or Vulvar atrophy—Intramuscular, 100 to 500 mcg (0.1 to 0.5 mg) two or three times a week, cyclically or continuously as appropriate. Estrogen deficiency, due to
8080:
Estrone has been marketed under a variety of brand names, including
Andrestraq, Aquacrine, A.T.V., Bestrone, Centrogen, Cicatral, Cormone, Crinovaryl, Cristallovar, Crystogen, Destrone, Disynformon, Endofolliculina, Estragyn, Estroject, Estrol, Estrone, Estrone Aqueous Suspension, Estrone-A,
10624:
Using the same principle of delayed absorption, however, we have been able to improve the efficiency of estrone by suspending this fat soluble substance in an aqueous medium, reversing the procedure of suspending water soluble substances such as penicillin. in oil.3 The action of estrone in
11292:
We have already reported our employing injections of estrone crystals suspended in aqueous medium in order to obtain freedom from allergic reactions (1). This preparation, now available commercially, has proven satisfactory not only from this standpoint, but also because of its increased
5801:. In addition, estradiol levels were found to correlate with these effects, while estrone levels did not. These findings confirm that estrone has very low estrogenic activity, and also indicate that estrone does not diminish the estrogenic activity of estradiol. This contradicts some
7048:
injection of estrone in aqueous solution, the water from the preparation is absorbed and a microcrystalline depot of estrone that is slowly absorbed by the body is formed. This is responsible for the prolonged duration of estrone in aqueous suspension compared to oil solution.
4378:
values are of the format "median (range)" (# (#–#)), "range" (#–#), or "value" (#) depending on the values available. The full sets of values within the ranges can be found in the Wiki code. (2) Binding affinities were determined via displacement studies in a variety of
4425:
8088:
Brand names of estrone in aqueous suspension specifically include
Bestrone, Estaqua, Estrofol, Estroject, Estrone-A, Estronol, Femogen, Foygen Aqueous, Gravigen Aqueous, Gynogen, Hormogen-A, Kestrin Aqueous, Kestrone, Theelin Aqueous, Theogen, Unigen, and Wehgen.
10204:
Selby P, McGarrigle HH, Peacock M (March 1989). "Comparison of the effects of oral and transdermal oestradiol administration on oestrogen metabolism, protein synthesis, gonadotrophin release, bone turnover and climacteric symptoms in postmenopausal women".
10462:
De
Lignieres B, Basdevant A, Thomas G, Thalabard JC, Mercier-Bodard C, Conard J, Guyene TT, Mairon N, Corvol P, Guy-Grand B (March 1986). "Biological effects of estradiol-17 beta in postmenopausal women: oral versus percutaneous administration".
6382:
10257:
Powers MS, Schenkel L, Darley PE, Good WR, Balestra JC, Place VA (August 1985). "Pharmacokinetics and pharmacodynamics of transdermal dosage forms of 17 beta-estradiol: comparison with conventional oral estrogens used for hormone replacement".
8979:
American
Medical Association. Dept. of Drugs; Council on Drugs (American Medical Association); American Society for Clinical Pharmacology and Therapeutics (1 February 1977). "Estrogens, Progestagens, Oral Contraceptives, and Ovulatory Agents".
4418:
998:. The range of single doses of estrone by intramuscular injection that are typically used clinically in women is 0.1 to 5 mg. High doses of intramuscular estrone have been used for prostate cancer in men and for breast cancer in women.
10903:
ovariectomy or Female hypogonadism or
Primary ovarian failure—Intramuscular, 100 mcg (0.1 mg) to 1 mg a week, administered as a single dose or in divided doses, cyclically or continuously. A few patients may need doses of up to 2 mg a week.
7644:
4411:
1241:
5039:
6375:
1076:
Although estrone by intramuscular injection was originally formulated as an oil solution, it was soon replaced by formulations of estrone as an aqueous suspension due to a longer duration of action of these formulations.
9841:
Escande A, Pillon A, Servant N, Cravedi JP, Larrea F, Muhn P, Nicolas JC, Cavaillès V, Balaguer P (2006). "Evaluation of ligand selectivity using reporter cell lines stably expressing estrogen receptor alpha or beta".
7637:
872:
Estrone was first discovered in 1929, and was introduced for medical use shortly thereafter. Although it has been used clinically in the past, estrone has largely been discontinued and is mostly no longer marketed.
6368:
1234:
7630:
5032:
10625:
suspension is prolonged because the water vehicle is rapidly absorbed leaving a deposit of crystals in the tissues thus behaving like small implants of crystals which we know are relatively long acting.
9398:
Synergon, a combination of progesterone and oestrone in an injectable form, is marketed to induce withdrawal bleeding in women with nongravid amenorrhea; however, it can be used as an arbortifacient .
1227:
5025:
10005:
Dang Z, Ru S, Wang W, Rorije E, Hakkert B, Vermeire T (March 2011). "Comparison of chemical-induced transcriptional activation of fish and human estrogen receptors: regulatory implications".
7072:, with the remainder (2.0 to 4.0%) circulating free or unbound. Estrone has about 24% of the relative binding affinity of estradiol for SHBG, and hence is relatively poorly bound to SHBG.
7531:
of estrone and estradiol in the circulation are both about 10 to 70 minutes, whereas the biological half-life of estrone sulfate in the circulation is about 10 to 12 hours. The
12640:
12635:
8978:
10110:"Estriol and estrone interaction with the estrogen receptor. II. Estriol and estrone-induced inhibition of the cooperative binding of [3H]estradiol to the estrogen receptor"
8711:
Fishman J, Martucci CP (1980). "New
Concepts of Estrogenic Activity: The Role of Metabolites in the Expression of Hormone Action". In Pasetto N, Paoletti R, Ambrus JL (eds.).
5838:
14521:
5777:
estradiol, clinical studies have shown that doses of oral and transdermal estradiol achieving similar levels of estradiol possess equivalent and non-significantly different
616:
8111:
Although estrone has been widely marketed in the past, it has mostly been discontinued and remains available in only a few countries. These countries reportedly include
1065:(0.135 mg, 0.27 mg) has been marketed under the brand name Hormonin as well. In addition, a combined injectable preparation containing estrone (1 mg) and
982:
Estrone has been used by intramuscular injection at a dosage of 0.1 to 2 mg per week, or 0.1 to 0.5 mg given 2 or 3 times per week, for the treatment of
10300:
Fåhraeus L, Larsson-Cohn U (December 1982). "Oestrogens, gonadotrophins and SHBG during oral and cutaneous administration of oestradiol-17 beta to menopausal women".
7544:, estrone was used at a dose of 0.1 to 0.5 mg 2 to 3 times per week, or at a dose of 0.1 to 2 mg once a week or in divided doses. In one rodent study,
14753:
14093:
7559:
The ratio of circulating estrone to circulating estradiol is the same at about 5:1 with both oral estradiol and oral estrone sulfate. An investigational estrone
12572:
5638:
changes) were all present in the women. Treatment with estrone was found to dose- and time-dependently produce a variety of effects, including breast changes,
11580:
10538:
Oestrone is weakly active by mouth, its potency (see Table) being approximately 1/25th that of stilboestrol (25 mg E1 = 1 mg DES = 2.5 mg CEEs = 0.05 mg EE).
10078:
Kloosterboer HJ, Schoonen WG, Verheul HA (11 April 2008). "Proliferation of Breast Cells by Steroid Hormones and Their Metabolites". In Pasqualini JR (ed.).
136:
83:
Oestrone; E1; Follicular hormone; Folliculin; Folliculine; Follikulin; Theelin; Ketohydroxyestrin; Oxohydroxyestrin; 3-Hydroxyestra-1,3,5(10)-trien-17-one
10761:"Studies on phenolic steroids in human subjects. II. The metabolic fate and hepato-biliary-enteric circulation of C14-estrone and C14-estradiol in women"
10435:
Friel PN, Hinchcliffe C, Wright JV (March 2005). "Hormone replacement with estradiol: conventional oral doses result in excessive exposure to estrone".
5831:
9579:
Ferin J (January 1952). "Relative duration of action of natural and synthetic estrogens administered parenterally in women with estrogen deficiency".
9364:
Addo VN, Tagoe-Darko ED (June 2009). "Knowledge, practices, and attitudes regarding emergency contraception among students at a university in Ghana".
14668:
6856:
14434:
12625:
6933:
in 10 to 20 women each. Vaginal smear test grades were 1 = atrophic, 2 = intermediate cells, 3 = early cornification, 4 = full cornification.
14485:
14477:
11515:
10384:
Wright JV (December 2005). "Bio-identical steroid hormone replacement: selected observations from 23 years of clinical and laboratory practice".
9237:
8436:
10152:
Lundström E, Conner P, Naessén S, Löfgren L, Carlström K, Söderqvist G (2015). "Estrone - a partial estradiol antagonist in the normal breast".
14060:
7104:
6976:
radioactivity with tritiated estrone was about one-tenth that of tritiated estradiol and almost all of the uterine radioactivity was estradiol.
14820:
14815:
14313:
14308:
14303:
14173:
5824:
986:
such as hot flashes and vaginal atrophy, and at a dosage of 0.1 to 1.0 mg weekly in single or divided doses for the treatment of female
14779:
14699:
14496:
13798:
13582:
640:
13285:
11073:
The first steroid hormone was isolated from the urine of pregnant women by Adolf Butenandt in 1929 (estrone; see Fig. 1) (Butenandt 1931).
1212:
the actions of estradiol, but this does not appear to be of clinical significance. In contrast to estradiol and estriol, estrone is not a
933:
in women. It has since largely been discontinued and is mostly no longer available, having been superseded by other estrogens with better
14571:
14566:
14338:
14263:
7563:
was found to result in a ratio of estrone to estradiol of 4:1 or 5:1 initially, but this decreased to about 1:1 with continuous therapy.
5567:). = Atypical uterotrophic effect which plateaus within 48 hours (estradiol's uterotrophy continues linearly up to 72 hours).
668:
InChI=1S/C18H22O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-16,19H,2,4,6-9H2,1H3/t14-,15-,16+,18+/m1/s1
14937:
14546:
14541:
14388:
14383:
12735:
12565:
12534:
12116:
9958:
Legler J, Zeinstra LM, Schuitemaker F, Lanser PH, Bogerd J, Brouwer A, Vethaak AD, De Voogt P, Murk AJ, Van der Burg B (October 2002).
8965:
14881:
14714:
14709:
14393:
14228:
14183:
13532:
11573:
10337:"International Union of Basic and Clinical Pharmacology. XCVII. G Protein-Coupled Estrogen Receptor and Its Pharmacologic Modulators"
10961:
Sipinen S, Lähteenmäki P, Luukkainen T (December 1980). "An oestrone-releasing vaginal ring in the treatment of climacteric women".
5555:
levels relative to baseline of ovariectomized rats after 24 to 72 hours of continuous administration via subcutaneous implant.
685:
14551:
14459:
14454:
14444:
14358:
14283:
13295:
10917:"17beta-hydroxysteroid dehydrogenase Type 1, and not Type 12, is a target for endocrine therapy of hormone-dependent breast cancer"
10728:
Radioactive Isotopes in Physiology Diagnostics and Therapy / Künstliche Radioaktive Isotope in Physiologie Diagnostik und Therapie
14398:
7234:
8948:
14074:
12107:
8875:
1880:
14876:
12558:
12524:
12491:
11504:
11370:
11343:
11316:
11215:
11066:
11039:
11009:
10895:
10743:
10089:
9893:
9472:
9345:
9320:
9293:
9264:
9204:
9170:
9122:
9047:
9020:
8991:
8927:
8846:
8762:
8728:
8690:
8654:
8620:
8573:
8531:
8499:
8340:
8306:
8224:
6849:
1173:
14871:
13367:
12845:
12529:
11930:
11566:
14605:
8025:
1217:
7493:
7344:
5741:
of estradiol, the ratio of estradiol levels to estrone levels is about 5 times higher on average than under normal
1185:
into estradiol, which is far more potent as an estrogen in comparison, most or all of the estrogenic potency of estrone
12830:
12825:
10639:"In vivo uptake and subcellular distribution of tritium-labeled estrogens in human endometrium, myometrium, and vagina"
7969:
for use by intramuscular injection was first described in 1941 and was introduced for medical use under the brand name
7097:
7851:
use. In 1929, pure crystalline estrone was isolated from the urine of pregnant women by various researchers. By 1929,
12878:
12316:
11645:
7998:
660:
12894:
12508:
12320:
11657:
6842:
13449:
13015:
11962:
11731:
14029:
5933:
5003:
4511:
338:
177:
13089:
13057:
11807:
11783:
9412:"A survey of knowledge, attitudes and practice of emergency contraception among university students in Cameroon"
7616:
13280:
12041:
8266:
9959:
429:
10808:
Brown JB (December 1957). "The relationship between urinary oestrogens and oestrogens produced in the body".
8034:
7548:
estrone was administered and increased circulating estradiol levels by about 10-fold; co-administration of a
7090:
14866:
13180:
12425:
12058:
11812:
8128:
7786:
7782:
7584:
7449:
7324:
7306:
7065:
6303:
6069:
5923:
5884:
5786:
5098:
4990:
4633:
4501:
1905:
1192:
823:
773:
480:
283:
116:
14630:
12740:
12715:
8155:
was developed and studied for use in menopausal hormone therapy. It increased estrogen levels, suppressed
4171:
4146:
1855:
1086:
14886:
13128:
12539:
12429:
10845:"Excretion of estrogen metabolites by humans. I. The fate of small doses of estrone and estradiol-17beta"
9960:"Comparison of in vivo and in vitro reporter gene assays for short-term screening of estrogenic activity"
7612:
7600:
7243:
6945:
6571:
1169:
9467:. International Organization of Consumers Unions, Regional Office for Asia and the Pacific. p. 15.
8106:
8102:
13133:
11829:
10592:
8007:
7441:
7402:
5774:
5758:
5703:
4977:
4491:
1111:
811:
726:
549:
17:
9197:
The Menopause and Postmenopause: The Proceedings of an International Symposium held in Rome, June 1979
5702:
of the endometrium, and reversal of vaginal and cervical atrophy, which were accompanied by increased
14188:
14098:
13320:
11641:
8172:
8082:
6817:
5522:
5106:
5065:
4934:
4921:
4443:
4196:
3846:
1270:
1264:
1066:
1007:
968:
757:
107:
1955:
14907:
14749:
14511:
14424:
14049:
13742:
13275:
13270:
13170:
11836:
11496:
Estrogens and Antiestrogens II: Pharmacology and Clinical Application of Estrogens and Antiestrogen
7843:
women. This rich source of estrogens allowed the development of potent estrogenic formulations for
7712:: estrone (E1) has one, estradiol (E2) has two, estriol (E3) has three, and estetrol (E4) has four.
7532:
5904:
5699:
2983:
8214:
1172:
of estrone for the human ERα and ERβ were 4.0% and 3.5% of those estradiol, respectively, and the
14037:
13947:
13572:
13562:
13497:
13025:
12795:
12496:
12001:
11979:
11763:
11759:
7948:
7892:
7541:
7033:
6930:
6682:
5953:
5754:
5727:
4964:
4481:
1830:
1164:
in mice, estradiol is about 10-fold more potent than estrone and about 100-fold more potent than
1119:
1017:
995:
972:
956:
882:
738:
95:
88:
70:
12835:
12810:
12750:
12745:
6348:. Liver = Ratio of liver estrogenic effects to general/systemic estrogenic effects (hot flashes/
2158:
2133:
14005:
13557:
13037:
12962:
12957:
12910:
11996:
11773:
11726:
10678:
Poirier D (September 2010). "17beta-Hydroxysteroid dehydrogenase inhibitors: a patent review".
9110:
9037:
8519:
8043:
7959:
7671:
7061:
7037:
6965:
6961:
6891:
6887:
6531:
6423:
5960:
5778:
5139:
4947:
4523:
2483:
1307:
1161:
1157:
1058:
1029:
934:
886:
862:
854:
749:
278:
223:
99:
12765:
11333:
11205:
11085:
Hammond CB, Maxson WS (January 1982). "Current status of estrogen therapy for the menopause".
11029:
9881:
9310:
9008:
8907:
8752:
8644:
8610:
8563:
8328:
529:
14278:
14103:
14041:
13567:
13111:
13074:
13062:
12930:
12413:
11797:
11791:
11721:
11691:
11601:
11589:
11516:"Pharmacology of estrogens and progestogens: influence of different routes of administration"
9281:
9252:
9221:
9158:
8836:
8678:
8437:"Pharmacology of estrogens and progestogens: influence of different routes of administration"
8182:
8056:
8016:
7928:
7920:
7888:
7687:
6753:
6642:
5203:
5052:
4925:
4917:
4471:
4438:
1380:
1256:
1213:
890:
715:
420:
305:
129:
12840:
12815:
12790:
12775:
12710:
12650:
12645:
11056:
10997:
9192:
7190:
5445:
4346:
4321:
2108:
2083:
1705:
13698:
13355:
13094:
13000:
12942:
12720:
12421:
11918:
11866:
11778:
11751:
11716:
11701:
10393:
9971:
8177:
8160:
8140:
8136:
7860:
7679:
7528:
7485:
7017:
6821:
6734:
6661:
6106:
6032:
5541:
5181:
4661:
2183:
1980:
1355:
1165:
1062:
1040:
1011:
781:
489:
297:
12780:
12655:
12630:
8258:
4046:
4021:
469:
8:
14759:
14674:
13738:
13522:
13379:
13345:
13155:
12855:
12473:
12417:
12341:
12235:
12067:
11747:
11743:
11676:
10915:
Day JM, Foster PA, Tutill HJ, Parsons MF, Newman SP, Chander SK, et al. (May 2008).
7952:
7912:
7900:
7852:
7844:
7802:
7588:
7549:
7453:
7147:
7069:
7006:
6898:
in around 10 women each. Vaginal cornification grade is percentage cornification of
6623:
6590:
6316:
5894:
5814:
5794:
5782:
5738:
5719:
5552:
5087:
3008:
2908:
1805:
1209:
1051:
1044:
991:
983:
942:
850:
753:
375:
288:
231:
215:
103:
12770:
10397:
9975:
384:
14927:
14841:
14625:
14506:
14088:
13702:
13362:
13020:
12937:
12882:
12725:
12685:
12675:
12615:
12584:
11925:
11871:
11755:
11739:
11696:
11649:
11546:
11430:
11405:
11386:
11181:
11164:
10785:
10760:
10703:
10615:
10524:
10499:
10417:
10361:
10336:
10230:
10218:
10177:
9935:
9910:
9909:
Coldham NG, Dave M, Sivapathasundaram S, McDonnell DP, Connor C, Sauer MJ (July 1997).
9722:
9556:
9539:
9438:
9411:
9389:
9231:
8809:
8792:
8467:
7966:
7774:
7580:
7537:
7445:
7025:
6922:
6899:
6895:
6813:
6809:
6783:
6550:
6484:
6282:
6278:
6217:
5864:
5691:
5667:
5659:
5639:
5591:
5560:
5313:
5291:
5269:
5247:
4885:
4579:
4551:
4121:
3333:
2333:
2208:
1930:
1580:
1555:
1530:
1505:
1099:
1021:
976:
949:
922:
906:
799:
730:
14429:
12705:
11466:
11136:
11098:
10861:
10844:
10568:
10551:
10126:
9662:
8098:
14922:
14439:
14213:
13662:
12670:
12665:
12592:
12581:
12433:
12246:
12096:
11787:
11735:
11610:
11538:
11500:
11470:
11435:
11366:
11339:
11312:
11283:
11248:
11244:
11211:
11186:
11140:
11102:
11062:
11035:
11005:
10978:
10974:
10938:
10891:
10866:
10825:
10790:
10739:
10695:
10660:
10619:
10573:
10529:
10480:
10444:
10409:
10366:
10317:
10275:
10271:
10222:
10169:
10131:
10085:
10057:
10053:
10022:
9987:
9940:
9889:
9859:
9818:
9814:
9770:
9766:
9753:
Werner AA, Collier WD (1933). "Production of Endometrial Growth in Castrated Women".
9714:
9666:
9631:
9627:
9596:
9561:
9515:
9468:
9443:
9381:
9341:
9316:
9289:
9260:
9200:
9166:
9118:
9091:
9087:
9043:
9016:
8987:
8923:
8842:
8814:
8758:
8724:
8686:
8650:
8616:
8569:
8527:
8495:
8459:
8336:
8302:
8262:
8220:
8116:
7955:
7848:
7806:
7752:
7473:
7398:
7371:
7252:
7112:
7028:
in terms of estrogenic potency. Due to its weak oral activity, estrone has been used
5765:
levels of estradiol, whereas estrone levels resemble the high levels seen during the
5707:
5635:
5583:
5526:
5335:
5057:
4951:
4938:
4461:
4451:
3996:
2458:
1780:
1182:
1145:
1095:
1054:
1047:
858:
835:
831:
795:
192:
40:
12820:
11550:
10707:
10421:
10234:
10181:
9726:
9393:
8565:
The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies
8471:
14932:
14917:
14912:
14689:
14158:
13123:
12870:
12755:
12695:
12690:
12680:
12660:
12620:
12308:
12296:
11908:
11824:
11637:
11530:
11462:
11425:
11417:
11275:
11240:
11176:
11132:
11094:
10970:
10928:
10856:
10817:
10780:
10772:
10731:
10687:
10650:
10607:
10563:
10519:
10511:
10472:
10401:
10356:
10348:
10309:
10267:
10214:
10161:
10121:
10049:
10014:
9979:
9930:
9922:
9851:
9810:
9762:
9706:
9658:
9623:
9588:
9551:
9507:
9433:
9423:
9373:
9142:
9083:
8915:
8879:
8804:
8716:
8451:
8294:
8254:
7994:
7944:
7794:
7743:
7709:
7553:
7481:
7477:
7457:
7422:
7197:
7183:
7173:
7157:
7057:
7041:
7021:
6969:
6957:
6787:
6180:
5802:
5773:. In spite of markedly elevated levels of estrone with oral estradiol but not with
5762:
5734:
5723:
5489:
5467:
5423:
5401:
5379:
5357:
4773:
4375:
4096:
3971:
3946:
2433:
2233:
1755:
1730:
1680:
1655:
1630:
1605:
1480:
1032:
938:
918:
745:
742:
565:
202:
160:
149:
12800:
10165:
7496:(17β-HSDs), and this accounts for most or all of its estrogenic activity. 17β-HSD
4433:
Relative affinities of estrogens for steroid hormone receptors and blood proteins
14248:
13981:
13855:
13487:
13434:
13389:
13190:
12392:
12328:
12016:
11969:
11846:
11494:
11360:
11306:
10885:
10735:
10691:
10079:
10018:
9462:
8981:
8489:
8298:
8065:
7828:
7824:
7798:
7778:
7722:
7469:
7410:
7383:
7140:
7009:
6798:
6290:
6143:
5943:
5874:
5811:
5790:
5766:
5675:
5663:
5623:
4829:
4071:
3433:
2758:
2308:
1206:
945:
926:
898:
819:
722:
719:
409:
264:
247:
210:
13959:
13955:
13933:
8919:
8720:
8127:. However, estrone remains widely available throughout the world in the form of
3533:
3508:
3458:
1191:
is actually due to conversion into estradiol. As such, similarly to the case of
1160:
estrogen than is estradiol, and as such is a relatively weak estrogen. Given by
14719:
14481:
14353:
13782:
13502:
13474:
13466:
13305:
13210:
13200:
13145:
13140:
13042:
12860:
12760:
12550:
12502:
12365:
12353:
11986:
11668:
10109:
9377:
7884:
7736:
7705:
7418:
5654:, and relief from the subjective symptoms of ovariectomy, as well as increased
4999:
4986:
4397:
proteins (except the ERβ values from Kuiper et al. (1997), which are rat ERβ).
4221:
3871:
11558:
11534:
9855:
8455:
7016:
form, a dose of 25 mg estrone is approximately equivalent to 2.5 mg
5594:
of estrogens in humans. In these studies, prior to administration of estrone,
5540:
rats after 72 hours with continuous administration of 1 μg/hour via
4296:
2958:
30:
This article is about estrone as a medication. For its role as a hormone, see
14901:
14333:
14168:
14143:
13923:
13841:
13674:
13652:
13507:
13384:
13116:
12967:
12925:
11952:
11453:
Bishop PM, Folley SJ (August 1951). "Absorption of hormone implants in man".
11252:
11144:
10998:"Historical Introduction to Gonadal Regulation of the Uterus and the Menses."
9822:
9774:
9718:
9710:
9670:
9635:
9519:
9095:
8491:
Melmon and Morrelli's Clinical Pharmacology: Basic Principles in Therapeutics
8249:
Guo JZ, Hahn DW, Wachter MP (2000). "Hormones, Estrogens and Antiestrogens".
7770:
7465:
7461:
7221:
7207:
7013:
6949:
6918:
6883:
6790:
6345:
5742:
5683:
4960:
4246:
2005:
1455:
1430:
930:
627:
256:
10515:
10405:
10040:
Kuhl H (September 1990). "Pharmacokinetics of oestrogens and progestogens".
7524:, although the relative contributions of the different isoforms is unknown.
14501:
14473:
14449:
14318:
14243:
14153:
14148:
14138:
13941:
13907:
13897:
13893:
13828:
13822:
13754:
13250:
13240:
13215:
13079:
13032:
12886:
12874:
12375:
12312:
12251:
12180:
12175:
12170:
12165:
12145:
12140:
12087:
12054:
12034:
12028:
12024:
11883:
11878:
11672:
11653:
11593:
11542:
11474:
11439:
11421:
11304:
11287:
11190:
11031:
The Evolution of Drug Discovery: From Traditional Medicines to Modern Drugs
10942:
10870:
10829:
10794:
10699:
10533:
10448:
10413:
10370:
10313:
10173:
10026:
9991:
9863:
9697:
Werner AA (1932). "Effect of Theelin Injections upon the Castrated Woman".
9651:
Journal of the American Pharmaceutical Association (Practical Pharmacy Ed.)
9600:
9565:
9447:
9410:
Kongnyuy EJ, Ngassa P, Fomulu N, Wiysonge CS, Kouam L, Doh AS (July 2007).
9385:
8818:
8463:
8156:
8152:
7990:
7940:
7895:. Other products and brand names of estrone marketed in the 1930s included
7560:
6926:
6902:
6416:
6349:
5746:
5671:
5544:
3789:
2808:
2733:
2708:
1025:
987:
734:
155:
144:
11358:
11106:
10982:
10821:
10664:
10484:
10476:
10352:
10321:
10279:
10226:
10135:
10061:
9944:
9511:
9498:
Freed SC, Greenhill JP (1941). "Therapeutic Use of Estrone Suspensions1".
9428:
8291:
Blood and Marrow Transplant Handbook: Comprehensive Guide for Patient Care
5607:
14846:
14774:
14739:
14734:
14694:
14664:
14650:
14640:
14635:
14464:
14408:
14403:
14298:
14293:
14273:
14223:
14198:
14193:
14118:
14108:
14025:
14021:
14017:
14009:
13999:
13995:
13963:
13951:
13937:
13929:
13869:
13802:
13746:
13718:
13552:
13527:
13399:
13300:
13175:
13099:
13069:
12920:
12900:
12850:
12804:
12700:
12409:
12382:
12361:
12357:
12349:
12334:
12324:
12276:
12215:
12210:
12160:
12048:
11991:
11817:
11767:
11686:
11627:
11279:
10655:
10638:
10611:
10577:
9926:
9592:
8488:
Melmon KL, Carruthers SG, Morrelli HF, Hoffman BB, Nierenberg DW (2000).
8132:
7962:
7876:
7868:
7818:
7790:
7732:
6411:
5913:
5854:
5810:
research suggesting that high concentrations of estrone might be able to
5726:
both during treatment and in the days following cessation of injections.
5715:
5695:
5687:
5679:
5647:
5631:
5619:
5587:
5537:
5225:
5082:
4973:
4717:
3761:
3733:
3658:
3633:
3608:
3483:
3383:
3258:
2883:
2858:
2533:
1405:
1091:
1036:
964:
914:
861:
in the body into estradiol, which provides most or all of its estrogenic
791:
769:
9614:
Freed SC (1941). "Present status of commercial endocrine preparations".
9352:
Estrone Progesterone Multi-ingredient: Fr.: Synergon Turk.: Synergon
8838:
The Estrogen Elixir: A History of Hormone Replacement Therapy in America
8289:
Speroff L (2015). "Women's Hormonal Health Issues". In Speroff L (ed.).
449:
57:
14789:
14769:
14744:
14591:
14536:
14491:
14469:
14378:
14373:
14343:
14328:
14323:
14288:
14178:
14133:
14113:
13991:
13985:
13889:
13877:
13837:
13818:
13794:
13778:
13688:
13684:
13658:
13644:
13597:
13592:
13587:
13577:
13547:
13517:
13512:
13492:
13429:
13350:
13330:
13315:
13310:
13255:
13205:
13106:
13047:
12980:
12975:
12952:
12890:
12865:
12458:
12399:
12281:
12266:
12225:
12200:
12190:
12185:
12155:
12130:
11974:
11940:
11913:
11903:
11898:
11888:
11861:
11856:
11711:
11706:
8085:), Theelin, Thynestron, Tokokin, Unden, Unigen, Wehgen, and Wynestron.
7592:
7414:
7375:
7029:
6805:
6391:
Potencies and durations of natural estrogens by intramuscular injection
5750:
5595:
5564:
4745:
4386:
3921:
3896:
3683:
3408:
3308:
3283:
3158:
3058:
2783:
2683:
2658:
2633:
2608:
2558:
2408:
2383:
843:
592:
460:
272:
124:
13290:
12785:
10933:
10916:
10776:
9983:
9039:
Handbook of drug therapy in reproductive endocrinology and infertility
7500:
that are involved in the conversion of estrone into estradiol include
2933:
14784:
14764:
14704:
14684:
14526:
14363:
14238:
14233:
14218:
14203:
14163:
14045:
14013:
13971:
13919:
13915:
13911:
13901:
13881:
13865:
13814:
13790:
13786:
13774:
13766:
13762:
13722:
13710:
13694:
13680:
13670:
13666:
13622:
13482:
13456:
13444:
13419:
13409:
13394:
13374:
13325:
13225:
13220:
13195:
13185:
13150:
13010:
12985:
12947:
12905:
12386:
12369:
12345:
12286:
12261:
12195:
12150:
11957:
11945:
11935:
11851:
11841:
11664:
9908:
8646:
Concise Dictionary of Pharmacological Agents: Properties and Synonyms
7904:
7840:
7832:
7572:
7545:
7406:
7379:
7133:
7116:
6794:
6270:
5798:
5770:
4857:
4801:
3583:
3358:
3183:
3108:
2583:
2508:
2358:
2283:
2258:
2058:
910:
902:
846:
395:
318:
260:
12730:
10461:
9340:(36th ed.). London: Pharmaceutical Press. pp. 2101, 2127.
9219:
6801:
is 30–640 µg/d (6.4–8.6 mg total per month or cycle). The
3033:
1061:(0.3 mg, 0.6 mg), estrone (0.7 mg, 1.4 mg), and
14655:
14645:
14348:
14208:
14128:
14123:
14056:
13873:
13810:
13806:
13770:
13758:
13730:
13726:
13714:
13706:
13636:
13424:
13414:
13260:
13245:
13230:
13165:
13160:
13005:
12915:
12468:
12403:
12304:
12135:
11680:
11633:
7880:
7521:
7386:
7056:
Unlike estradiol and estriol, estrone is not accumulated in target
5806:
4381:
4271:
3233:
2833:
1201:
1103:
839:
803:
509:
440:
12117:
11266:
Freed SC (June 1946). "Diethylstilbestrol in aqueous suspension".
10637:
Wiegerinck MA, Poortman J, Donker TH, Thijssen JH (January 1983).
9801:
Werner AA (1937). "Effective Clinical Dosages of Theelin in Oil".
9226:. University of California Press. pp. 49–. GGKEY:2UAAZRZ5LN0.
615:
14810:
14556:
14368:
14268:
14258:
14253:
14033:
13977:
13967:
13859:
13734:
13542:
13537:
13439:
13404:
13335:
13235:
13084:
13052:
12990:
12453:
12006:
9911:"Evaluation of a recombinant yeast cell estrogen screening assay"
9074:
Fluhmann CF (1944). "Clinical use of extracts from the ovaries".
7936:
7728:
7725:
7517:
7513:
7509:
7505:
7501:
7497:
7394:
7390:
7214:
7165:
5627:
5599:
5533:
4689:
3558:
3133:
3083:
2033:
1196:
1187:
1141:
1070:
894:
866:
827:
765:
31:
11231:
Novak E (1935). "The Therapeutic Use of Estrogenic Substances".
10636:
9957:
7935:(Paines & Byrne), among others. These formulations included
7699:
7488:. Both of these transformations take place predominantly in the
7362:
14729:
14724:
14581:
13845:
13833:
13648:
13617:
13612:
13607:
13340:
12995:
8487:
8124:
8120:
8112:
7891:
that included estrone, were being sold commercially for use by
7740:
7721:
Estrone, also known as estra-1,3,5(10)-trien-3-ol-17-one, is a
7315:
7291:
7282:
7267:
7261:
6973:
6880:
6802:
5655:
5651:
5643:
5615:
5611:
5603:
5586:
in the 1930s, estrone was given via intramuscular injection to
5530:
5076:
5047:
Selected biological properties of endogenous estrogens in rats
3708:
1107:
960:
807:
540:
14075:
12108:
9336:
Sweetman SC, ed. (2009). "Sex hormones and their modulators".
8685:. Springer Science & Business Media. pp. 60, 62, 64.
8213:
Sweetman SC, ed. (2009). "Sex hormones and their modulators".
5536:. Uterine weight = Percentage change in uterine wet weight of
4394:
4390:
1300:
1295:
1290:
1285:
1153:
1149:
14805:
14679:
14561:
14531:
13750:
13632:
13461:
10151:
8219:(36th ed.). London: Pharmaceutical Press. p. 2101.
7836:
7596:
7576:
7492:. Estrone can also be reversibly converted into estradiol by
7489:
6953:
6905:
and is 1 (+) = 10–25%, 2 (++) = 25–50%, and 3 (+++) = 50–75%.
5718:, pelvic fullness, a "bearing-down" sensation, and increased
5711:
3208:
1115:
815:
606:
520:
323:
252:
11359:
Inc United States Pharmacopeial Convention (February 1987).
10960:
9409:
7793:(piperazine estrone sulfate), and the never-marketed esters
5733:
Clinical research has confirmed the nature of estrone as an
14825:
14606:
14516:
13885:
13640:
10077:
9840:
8943:
8941:
8939:
8914:. Springer Science & Business Media. pp. 135–165.
6262:
Values are ratios, with estradiol as standard (i.e., 1.0).
3817:
1250:
Affinities of estrogen receptor ligands for the ERα and ERβ
500:
10887:
USP DI 2003: Drug Information for Healthcare Professionals
14660:
7999:
5590:
women in order to study its effects and to elucidate the
48:
10256:
9888:. Springer Science & Business Media. pp. 548–.
9015:. Springer Science & Business Media. pp. 153–.
8936:
8649:. Springer Science & Business Media. pp. 207–.
929:
in men as well as a form of high-dose estrogen to treat
9250:
9223:
Hospital Formulary and Compendium of Useful Information
9115:
Principles and Practice of Endocrinology and Metabolism
6816:
has been reported as 5 to 7 mg/week. An effective
6337:
5934:
5730:
also occurred with sufficiently high doses of estrone.
5004:
4512:
12976:
Epiestriol (16β-epiestriol, 16β-hydroxy-17β-estradiol)
12393:
12376:
12042:
12035:
11004:. Springer Science & Business Media. pp. 8–.
10914:
10434:
10203:
9500:
The Journal of Clinical Endocrinology & Metabolism
9464:
Adverse Effects: Women and the Pharmaceutical Industry
9199:. Springer Science & Business Media. pp. 3–.
9186:
9184:
9182:
8706:
8704:
8702:
8517:
8483:
8481:
8026:
7595:
estrone in women, almost 90% is excreted in urine and
729:
and for other indications. It has been provided as an
362:)-3-hydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6
11379:
11233:
JAMA: The Journal of the American Medical Association
11054:
9616:
JAMA: The Journal of the American Medical Association
9493:
9491:
9489:
9487:
9279:
9117:. Lippincott Williams & Wilkins. pp. 2153–.
8679:"Biologic effects of natural and synthetic estrogens"
8333:
Textbook of Therapeutics: Drug and Disease Management
8035:
1205:
research has suggested that estrone might be able to
12059:
11980:
Methestrol dipropionate (promethestrol dipropionate)
11305:
International Agency for Research on Cancer (1979).
11268:
The Journal of Clinical Endocrinology and Metabolism
11123:
Biskind MS (1935). "Commercial Glandular Products".
10552:"Vaginal absorption of estrone and 17beta-estradiol"
10549:
10299:
9748:
9746:
9744:
9742:
9740:
9738:
9736:
9581:
The Journal of Clinical Endocrinology and Metabolism
9280:
Campbell G, Compston J, Crisp A (25 November 1993).
9273:
8901:
8899:
8897:
8335:. Lippincott Williams & Wilkins. pp. 397–.
7620:
7080:
6333:
6304:
6299:
5924:
5885:
5099:
4991:
4502:
849:. It is a relatively weak estrogen, with much lower
237:
11048:
10081:
Breast Cancer: Prognosis, Treatment, and Prevention
9179:
8699:
8605:
8478:
428:
12122:Tooltip selective estrogen receptor downregulators
11365:. United States Pharmacopeial. pp. 765, 770.
11078:
10758:
10334:
9484:
8603:
8601:
8599:
8597:
8595:
8593:
8591:
8589:
8587:
8585:
8513:
8511:
8008:
4978:
4492:
1020:was provided as 1, 2, 2.5, 3, 4, and 5 mg/mL
11492:
11335:Ashgate Handbook of Endocrine Agents and Steroids
11055:Nielsch U, Fuhrmann U, Jaroch S (30 March 2016).
10726:Dorfman RI (1961). "Steroid Hormone Metabolism".
10073:
10071:
9733:
9286:The Management of Common Metabolic Bone Disorders
9193:"Chemistry and biochemistry of natural estrogens"
8894:
8754:Science In The Bedroom: A History Of Sex Research
8676:
8638:
8636:
8634:
8632:
8518:Nakamoto J, Salameh WA, Carlton E (18 May 2010).
7777:and described. These include the marketed esters
5518:
5107:
5066:
108:
14899:
12580:
10550:Schiff I, Tulchinsky D, Ryan KJ (October 1977).
10004:
9479:Synergon. 10 mg progesterone. 1 mg folliculine .
9143:https://www.micromedexsolutions.com/micromedex2/
9000:
8672:
8670:
8668:
8666:
8612:Index Nominum 2000: International Drug Directory
7831:discovered that large amounts of estrogens were
6325:
5905:
5577:
959:, if estrone is taken by a woman with an intact
408:
11946:Mestilbol (diethylstilbestrol monomethyl ether)
11588:
11311:. International Agency for Research on Cancer.
11158:
11156:
11154:
10147:
10145:
9836:
9834:
9832:
9363:
9244:
9108:
9069:
9067:
9065:
9063:
8986:. Publishing Sciences Group. pp. 540–572.
8786:
8784:
8782:
8780:
8778:
8746:
8744:
8742:
8740:
8710:
8582:
8508:
8430:
8428:
8426:
8424:
8422:
8420:
8418:
8416:
8414:
8412:
8410:
8408:
8406:
8404:
8402:
8400:
8398:
8396:
8394:
8392:
8390:
8388:
8386:
8384:
8382:
8380:
8378:
8376:
8374:
8372:
8322:
8320:
8318:
8251:Kirk-Othmer Encyclopedia of Chemical Technology
7012:. It has been said that, taken by mouth in non-
4965:
4482:
383:
14080:Tooltip Selective estrogen receptor modulators
13435:Furostilbestrol (diethylstilbestrol difuroate)
12796:16β,17α-Epiestriol (16β-hydroxy-17α-estradiol)
12113:Tooltip selective estrogen receptor modulators
11352:
11118:
11116:
10989:
10956:
10954:
10952:
10877:
10721:
10719:
10717:
10295:
10293:
10291:
10289:
10252:
10250:
10248:
10246:
10244:
10199:
10197:
10195:
10193:
10191:
10103:
10101:
10068:
9875:
9873:
9497:
9329:
9195:. In Paoletti R, Pasetto N, Ambrus JL (eds.).
8830:
8828:
8629:
8494:. McGraw Hill Professional. pp. 614–615.
8370:
8368:
8366:
8364:
8362:
8360:
8358:
8356:
8354:
8352:
8248:
8044:
5781:in terms of measures including suppression of
12626:3-Methyl-19-methyleneandrosta-3,5-dien-17β-ol
12566:
11936:Dimestrol (diethylstilbestrol dimethyl ether)
11574:
11362:Drug Information for the Health Care Provider
11084:
11023:
11021:
10842:
10107:
9796:
9794:
9792:
9790:
9788:
9786:
9784:
9752:
9692:
9690:
9688:
9686:
9684:
9682:
9680:
9454:
9220:University of California (1868-1952) (1952).
9152:
9150:
9138:
9136:
9134:
8677:Quirk Jr JG, Wendel Jr GD (6 December 2012).
8663:
8615:. Taylor & Francis. 2000. pp. 407–.
8284:
8282:
8280:
8278:
8244:
8242:
8240:
8238:
8236:
8068:, but the spelling was eventually changed to
8057:
8055:, in which the "O" is silent, was the former
8017:
7638:
7617:List of estrogen esters § Estrone esters
7417:of estradiol that have one or more available
7098:
6850:
6376:
5832:
5033:
4926:
4472:
4419:
1235:
306:
12736:10β,17β-Dihydroxyestra-1,4-dien-3-one (DHED)
11452:
11446:
11397:
11293:effectiveness over estrone dissolved in oil.
11259:
11151:
10908:
10836:
10752:
10671:
10491:
10428:
10377:
10328:
10142:
9998:
9951:
9829:
9533:
9531:
9529:
9403:
9357:
9288:. Cambridge University Press. pp. 48–.
9251:Krishna UR, Sheriar NK, Mandlekar A (1996).
9060:
9006:
8905:
8870:
8868:
8866:
8864:
8862:
8860:
8858:
8775:
8737:
8526:. Elsevier Health Sciences. pp. 2813–.
8315:
8208:
8206:
8204:
8202:
8200:
8198:
7613:List of estrogens § Estrone derivatives
6925:(Estrotate) and estrone (Theelin-In-Oil) in
1028:. It has also been available in the form of
14611:Tooltip G protein-coupled estrogen receptor
13430:Fosfestrol (diethylstilbestrol diphosphate)
12068:
11941:Fosfestrol (diethylstilbestrol diphosphate)
11493:Oettel M, Schillinger E (6 December 2012).
11197:
11125:Journal of the American Medical Association
11113:
10949:
10714:
10630:
10455:
10286:
10241:
10188:
10098:
10033:
9902:
9886:Clinical Endocrinology: Theory and Practice
9870:
9803:Journal of the American Medical Association
9755:Journal of the American Medical Association
9649:Stempel E (1959). "prolonged drug action".
9642:
9302:
9236:: CS1 maint: numeric names: authors list (
9076:Journal of the American Medical Association
8825:
8793:"Estrogenic Hormones: Their Clinical Usage"
8524:Endocrinology – E-Book: Adult and Pediatric
8349:
6317:
6312:
5895:
5548:
5088:
13573:Triphenylmethylethylene (triphenylpropene)
12897:, many others; via estrogenic metabolites)
12821:17α-Epiestriol (16α-hydroxy-17α-estradiol)
12573:
12559:
11581:
11567:
11298:
11018:
10883:
10759:Sandberg AA, Slaunwhite WR (August 1957).
10543:
9781:
9677:
9147:
9131:
9102:
9029:
8642:
8557:
8555:
8553:
8551:
8549:
8547:
8545:
8543:
8275:
8233:
8159:levels, and relieved menopausal symptoms.
7645:
7631:
7105:
7091:
6952:(dpm/mg tissue or dpm/5 μL blood) in
6857:
6843:
6383:
6369:
6274:
5865:
5839:
5825:
5040:
5026:
4426:
4412:
1242:
1228:
468:
12593:
12097:
11862:Prasterone (dehydroepiandrosterone; DHEA)
11611:
11499:. Springer Science & Business Media.
11429:
11325:
11224:
11180:
11162:
10932:
10860:
10801:
10784:
10654:
10584:
10567:
10523:
10360:
10125:
9934:
9879:
9607:
9572:
9555:
9526:
9460:
9437:
9427:
9190:
8855:
8808:
8195:
8004:Tooltip International Nonproprietary Name
7556:decreased estradiol levels by about 50%.
5515:
5058:
4952:
4939:
4462:
4452:
1087:Estrogen (medication) § Side effects
1069:(10 mg) is available in the form of
488:
11818:Estropipate (piperazine estrone sulfate)
11406:"Clinical Experiment in Oestrin Therapy"
11034:. John Wiley & Sons. pp. 175–.
10335:Prossnitz ER, Arterburn JB (July 2015).
9335:
9073:
9007:Thomas JA, Keenan EJ (6 December 2012).
8906:Thomas JA, Keenan EJ (6 December 1986).
8790:
8750:
8212:
8107:Esterified estrogens § Availability
8103:Conjugated estrogens § Availability
7652:Structures of major endogenous estrogens
7603:causes a delay in excretion of estrone.
7591:. Following an intravenous injection of
7064:, estrone is bound approximately 16% to
6344:= Increase in the serum levels of these
1140:Estrone is an estrogen, specifically an
917:women. Estrone has also been used as an
11338:. Taylor & Francis. pp. 138–.
11203:
11122:
10725:
10677:
9648:
9540:"Some Fundamentals in Estrogen Therapy"
9338:Martindale: The Complete Drug Reference
9308:
9111:"Compendium of Endocrine-Related Drugs"
8972:
8834:
8540:
8288:
8216:Martindale: The Complete Drug Reference
6341:
6291:
6286:
5944:
5939:Tooltip Corticosteroid-binding globulin
5875:
5658:. Breast changes specifically included
5009:Tooltip Corticosteroid-binding globulin
4517:Tooltip Corticosteroid binding globulin
1039:(0.2 mg, 0.25 mg) as well as
448:
75:Estragyn, Kestrin, Theelin, many others
14:
14900:
11403:
11027:
10383:
9800:
9696:
9213:
9156:
9035:
8643:Morton IK, Hall JM (6 December 2012).
8031:Tooltip Dénomination Commune Française
7976:
7685:
7669:
7413:) occurs in the case of estradiol and
7351:
7342:
7337:
7322:
7313:
7289:
7280:
7250:
7241:
7219:
7212:
7195:
7188:
7171:
7162:
7044:of vaginal estrone have been studied.
1135:
12554:
11562:
11331:
11265:
11230:
10995:
10807:
10765:The Journal of Clinical Investigation
10590:
10497:
9613:
9578:
9537:
8522:. In Jameson JL, De Groot LJ (eds.).
8326:
8259:10.1002/0471238961.05192018072115.a01
8040:Tooltip Denominazione Comune Italiana
7677:
7664:
7304:
7259:
7232:
7205:
7181:
7155:
7145:
7138:
5952:
5942:
5932:
5922:
5903:
5893:
5883:
5873:
5863:
5853:
5846:Relative oral potencies of estrogens
5761:dosages of estradiol results in low,
5757:of estradiol. Oral administration of
1174:relative transactivational capacities
548:
528:
186:
12064:Tooltip follicle-stimulating hormone
11513:
10890:. Thomson Micromedex. p. 1246.
10039:
9255:. In Krishna UR, Sheriar NK (eds.).
9109:Misra D, Magee MF, Nylén ES (2001).
9013:Principles of Endocrine Pharmacology
8912:Principles of Endocrine Pharmacology
8908:"Estrogens and Antiestrogenic Drugs"
8561:
8434:
7750:was derived from the chemical terms
7131:
6309:Tooltip follicle-stimulating hormone
5929:Tooltip Sex hormone-binding globulin
5890:Tooltip Follicle-stimulating hormone
5104:Tooltip Sex hormone-binding globulin
4996:Tooltip sex hormone-binding globulin
4507:Tooltip Sex hormone-binding globulin
784:(mostly estrone sulfate; brand name
159:
148:
11165:"Sex Hormone Therapy in Gynæcology"
10849:The Journal of Biological Chemistry
9009:"Estrogen and Antiestrogenic Drugs"
8958:
7887:and containing purified estrone or
7735:at the C1, C3, and C5 positions, a
6995:
6921:test grade with different doses of
6329:
6266:
5914:
5855:
1218:G protein-coupled estrogen receptor
1130:
508:
399:
24:
12469:Androvax (androstenedione albumin)
11485:
11207:Biological Actions of Sex Hormones
10843:Beer CT, Gallagher TF (May 1955).
10219:10.1111/j.1365-2265.1989.tb02232.x
10108:Sasson S, Notides AC (July 1983).
9259:. Orient Blackswan. pp. 70–.
8163:of estrone has also been studied.
8013:Tooltip United States Pharmacopeia
7879:), purified from pregnancy urine,
4983:Tooltip mineralocorticoid receptor
4497:Tooltip Mineralocorticoid receptor
1118:, among others. It can also cause
1094:of estrogens like estrone include
1001:
794:of estrogens like estrone include
25:
14949:
14938:Sex hormone esters and conjugates
13972:taleranol (teranol, β-zearalanol)
12887:metandienone (methandrostenolone)
12535:Progestogens and antiprogestogens
11137:10.1001/jama.1935.92760350007009a
9699:Experimental Biology and Medicine
7494:17β-hydroxysteroid dehydrogenases
7005:Like estradiol, estrone has poor
5112:Tooltip relative binding affinity
5071:Tooltip relative binding affinity
113:Tooltip estradiol/estrone/estriol
14882:Progesterone receptor modulators
14636:Afimoxifene (4-hydroxytamoxifen)
13518:Prinaberel (ERB-041, WAY-202041)
11931:Diethylstilbestrol esters/ethers
11926:Diethylstilbestrol (stilbestrol)
11245:10.1001/jama.1935.92760200002012
11058:New Approaches to Drug Discovery
10730:. Springer. pp. 1223–1241.
9880:Schriener WE (6 December 2012).
9815:10.1001/jama.1937.02780390029011
9767:10.1001/jama.1933.02740440026008
9628:10.1001/jama.1941.72820400003010
9088:10.1001/jama.1944.02850190003001
8161:Subcutaneous pellet implantation
7981:
7698:
7656:
7397:) in humans. In addition to the
7361:
7123:
6938:
6910:
6872:
5910:Tooltip High-density lipoprotein
1195:, estrone is considered to be a
889:formulations and was used as an
576:
56:
47:
14579:Coregulator-binding modulators:
12846:17β-Methyl-17α-dihydroequilenin
10921:International Journal of Cancer
10084:. CRC Press. pp. 343–366.
9191:Deghenghi R (6 December 2012).
8966:"Drugs@FDA: FDA-Approved Drugs"
8797:California and Western Medicine
8713:The Menopause and Postmenopause
8331:. In Helms RA, Quan DJ (eds.).
8099:Estropipate § Availability
8092:
7051:
6968:or 0.11 μg 6,7-estrone in
5514:Values are mean ± SD or range.
4970:Tooltip glucocorticoid receptor
4487:Tooltip Glucocorticoid receptor
1220:(affinity >10,000 nM).
1125:
1080:
1073:under the brand name Synergon.
963:, it should be combined with a
876:
673:Key:DNXHEGUUPJUMQT-CBZIJGRNSA-N
13410:Erteberel (SERBA-1, LY-500307)
12474:Ovandrotone albumin (Fecundin)
11660:) (via estrogenic metabolites)
11210:. CUP Archive. pp. 558–.
11163:Johnstone RW (November 1936).
8757:. Basic Books. pp. 128–.
8135:(piperazine estrone sulfate),
8075:
8049:Tooltip Japanese Accepted Name
7746:at the C17 position. The name
7536:about 2 or 3 days. As an
1168:. According to one study, the
702:), sold under the brand names
582:
570:
13:
1:
14867:Receptor/signaling modulators
12831:17α-Ethynyl-3β-androstanediol
12826:17α-Ethynyl-3α-androstanediol
11467:10.1016/S0140-6736(51)93237-0
11099:10.1016/S0015-0282(16)45970-4
10996:Gruhn JG (11 November 2013).
10884:Micromedex (1 January 2003).
10862:10.1016/S0021-9258(18)70972-1
10593:"Management of the Menopause"
10569:10.1016/S0015-0282(16)42855-4
10166:10.3109/09513590.2015.1062866
10127:10.1016/S0021-9258(20)82036-5
9663:10.1016/S0095-9561(16)35628-6
9253:"Hormone Replacement Therapy"
9157:Modell W (21 November 2013).
9042:. Little, Brown. p. 23.
8791:Fluhmann CF (November 1938).
8188:
8062:Tooltip British Approved Name
8022:Tooltip British Approved Name
7759:(estra-1,3,5(10)-triene) and
7075:
7000:
6465:0.5–2 ≈ 2–7 d; 3.5 ≈ >5 d
5578:Effects in the body and brain
4931:Tooltip progesterone receptor
4477:Tooltip Progesterone receptor
1881:Estradiol 3-gluc. 17β-sulfate
881:Estrone has been marketed in
818:, among others. Estrone is a
648:O=C43(CC2c1ccc(O)cc1CC23CC4)C
632:254.5 °C (490.1 °F)
366:-cyclopentaphenanthren-17-one
311:Tooltip Intravenous injection
14877:Androgen receptor modulators
13181:Lynestrenol phenylpropionate
12525:Estrogen receptor modulators
12426:hydroxyprogesterone caproate
11332:Milne GW (1 November 2017).
10975:10.1016/0378-5122(80)90031-6
10810:The Journal of Endocrinology
10736:10.1007/978-3-642-49761-2_39
10692:10.1517/13543776.2010.505604
10272:10.1016/0002-9378(85)90569-1
10054:10.1016/0378-5122(90)90003-O
10019:10.1016/j.toxlet.2010.12.020
9309:Erkkola R (1 January 2006).
8715:. Springer. pp. 43–52.
8299:10.1007/978-3-319-13832-9_28
7787:estrone tetraacetylglucoside
7606:
7566:
7066:sex hormone-binding globulin
6566:40 ≈ 14–21 d; 100 ≈ 21–28 d
5787:follicle-stimulating hormone
1041:subcutaneous pellet implants
7:
14872:Estrogens and antiestrogens
14522:Oxabicycloheptene sulfonate
14209:Etacstil (GW-5638, DPC-974)
13385:Doisynoestrol (fenocycline)
13129:Ethinylestradiol 3-benzoate
12641:3β,5α-Dihydrolevonorgestrel
12636:3α,5α-Dihydrolevonorgestrel
12530:Androgens and antiandrogens
12466:Androstenedione immunogens:
12430:medroxyprogesterone acetate
12073:Tooltip luteinizing hormone
11953:Doisynoestrol (fenocycline)
9315:. Elsevier. pp. 264–.
8920:10.1007/978-1-4684-5036-1_7
8841:. JHU Press. pp. 21–.
8835:Watkins ES (6 March 2007).
8751:Bullough VL (19 May 1995).
8721:10.1007/978-94-011-7230-1_5
8568:. Springer. pp. 899–.
8562:Elks J (14 November 2014).
8166:
8146:
8064:of estrone and its name in
7853:pharmaceutical preparations
7601:Enterohepatic recirculation
6322:Tooltip luteinizing hormone
5900:Tooltip Luteinizing hormone
5694:changes included increased
5610:and small and non-erectile
5093:Tooltip Luteinizing hormone
4444:Relative binding affinities
2163:6,8-Didehydro-17α-estradiol
2138:6,8-Didehydro-17β-estradiol
1271:Absolute binding affinities
1265:Relative binding affinities
1170:relative binding affinities
1050:(1.25 mg). A combined
10:
14954:
14589:Noncompetitive inhibitors:
14214:Ethamoxytriphetol (MER-25)
13375:Dimestrol (dianisylhexene)
13134:Ethinylestradiol sulfonate
12451:Mixed mechanism of action:
12223:Noncompetitive inhibitors:
11975:Methestrol (promethestrol)
11830:Ethinylestradiol sulfonate
11028:Ravina E (18 April 2011).
11000:. In Josimovich JB (ed.).
10643:J. Clin. Endocrinol. Metab
10465:J. Clin. Endocrinol. Metab
9538:Freed SC (December 1946).
9378:10.1016/j.ijgo.2009.01.008
9165:. Springer. pp. 52–.
8096:
7971:Theelin Aqueous Suspension
7816:
7812:
7739:at the C3 position, and a
7610:
6253:
5870:Tooltip Vaginal epithelium
5817:the actions of estradiol.
5674:of the nipples as well as
1084:
1005:
727:menopausal hormone therapy
560:Chemical and physical data
29:
14859:
14834:
14798:
14631:7β-Hydroxyepiandrosterone
14618:
14604:
14417:
14189:Desmethylchlorotrianisene
14070:
13368:Diethylstilbestrol esters
13321:Bisdehydrodoisynolic acid
12741:11β-Chloromethylestradiol
12716:7β-Hydroxyepiandrosterone
12605:
12598:Tooltip Estrogen receptor
12591:
12486:
12443:
12295:
12234:
12208:Exclusively antagonistic:
12102:Tooltip Estrogen receptor
12095:
12086:
12015:
11616:Tooltip Estrogen receptor
11609:
11600:
11535:10.1080/13697130500148875
11169:Edinburgh Medical Journal
11061:. Springer. pp. 7–.
11002:Gynecologic Endocrinology
9856:10.1016/j.bcp.2006.02.002
9163:Drugs in Current Use 1958
8681:. In Buchsbaum HJ (ed.).
8456:10.1080/13697130500148875
8329:"Gynecological Disorders"
8173:Estradiol/estrone/estriol
7599:within 4 to 5 days.
7399:metabolic transformations
7032:instead, for instance by
6972:in rats. At 2 hours
6818:ovulation-inhibiting dose
6771:
6702:
6589:
6483:
6422:
6405:
6402:
6399:
6396:
5710:from the cervix, uterine
5523:Relative binding affinity
5510:
5063:Tooltip Estrogen receptor
4957:Tooltip estrogen receptor
4944:Tooltip androgen receptor
4912:
4467:Tooltip Androgen receptor
4457:Tooltip Estrogen receptor
4442:
4437:
4370:
4172:Ethinyl-3β-androstanediol
4147:Ethinyl-3α-androstanediol
3901:19-Nortestosterone; 19-NT
2938:16α-Lactone-17β-estradiol
2538:4-Hydroxytamoxifen; 4-OHT
2363:Dihydrodiethylstilbestrol
2188:8,9-Dehydro-17β-estradiol
1856:Estradiol 17β-glucuronide
1810:Estradiol 3,17β-disulfate
1710:16α-OH-E1; 17-Ketoestriol
1485:16β-Hydroxy-17α-estradiol
1460:16α-Hydroxy-17α-estradiol
1435:16β-Hydroxy-17β-estradiol
1279:
1269:
1263:
1260:
1255:
1181:. Because estrone can be
1035:(1 mg/g (0.1%)) and
1008:Estradiol/estrone/estriol
758:estradiol/estrone/estriol
714:among many others, is an
681:
656:
636:
626:
604:
591:
564:
559:
539:
519:
499:
479:
459:
439:
419:
394:
374:
334:
329:
317:
296:
271:
246:
222:
209:
201:
176:
171:
135:
123:
87:
79:
69:
64:
55:
46:
14695:Fulvestrant (ICI-182780)
14512:Methylpiperidinopyrazole
14465:Fulvestrant (ICI-182780)
13948:Resorcylic acid lactones
13171:Hydroxyestrone diacetate
13107:Etamestrol (eptamestrol)
11837:Hydroxyestrone diacetate
11764:estradiol ester mixtures
11404:Bishop PM (April 1938).
11204:Burrows H (March 2003).
10591:James DW (Summer 1998).
9915:Environ. Health Perspect
9711:10.3181/00379727-29-6259
8131:, which can be found in
7533:metabolic clearance rate
6824:is 20–30 mg/month.
6572:Estradiol benz. butyrate
6564:5 ≈ 7–8 d; 10 ≈ 10–14 d;
6498:1.66 ≈ 2–3 d; 5 ≈ 3–6 d
5542:subcutaneously implanted
3316:0.0054 (<0.001–0.01)
2984:Methylpiperidinopyrazole
2788:Deaminohydroxytoremifene
2313:17α-Methyl-17β-estradiol
1935:EB; Estradiol 3-benzoate
1785:E2S; Estradiol 3-sulfate
1385:E4; 15α,16α-Di-OH-17β-E2
865:. As such, estrone is a
14006:Synthetic xenoestrogens
13563:Triphenylchloroethylene
13498:Methestrol dipropionate
13026:Polyestradiol phosphate
12002:Triphenylchloroethylene
11760:polyestradiol phosphate
11087:Fertility and Sterility
10516:10.1136/bmj.1.5128.1029
10498:Swyer GI (April 1959).
10406:10.1196/annals.1356.039
10207:Clin. Endocrinol. (Oxf)
7949:intramuscular injection
7893:intramuscular injection
7542:intramuscular injection
7034:intramuscular injection
6931:intramuscular injection
6864:Pharmacology of estrone
6683:Polyestradiol phosphate
6296:Tooltip urinary calcium
5949:Tooltip Angiotensinogen
5880:Tooltip Urinary calcium
5728:Endometrial hyperplasia
5642:changes of the vagina,
4301:7α-Methylnorethisterone
4229:0.085 (0.0015–<0.1)
3929:0.038 (<0.001–0.04)
2563:4-Chlorotamoxifen; 4-CT
2288:RU-2858; 11β-Methoxy-EE
2113:7-Dehydro-17α-estradiol
2088:7-Dehydro-17β-estradiol
1831:Estradiol 3-glucuronide
1120:endometrial hyperplasia
1057:formulation containing
1018:intramuscular injection
996:primary ovarian failure
973:endometrial hyperplasia
957:route of administration
752:. It can also be taken
725:which has been used in
96:Intramuscular injection
14099:4'-Hydroxynorendoxifen
14094:2-Phenylbenzothiophene
13968:zeranol (α-zearalanol)
13671:phlorizin (phloridzin)
13558:Triphenylbromoethylene
13457:ICI-85966 (Stilbostat)
13038:Estramustine phosphate
12911:Bolandiol dipropionate
11997:Triphenylbromoethylene
11774:Estramustine phosphate
11422:10.1136/bmj.1.4034.939
10600:The Permanente Journal
10314:10.1530/acta.0.1010592
10260:Am. J. Obstet. Gynecol
9884:. In Labhart A (ed.).
9113:. In Becker KL (ed.).
7819:Estrone § History
7401:shown in the diagram,
7062:plasma protein binding
7038:vaginal administration
6962:subcutaneous injection
6888:subcutaneous injection
6886:(grade) with a single
6797:production during the
6532:Estradiol dipropionate
6406:Duration by dose (mg)
5789:levels, inhibition of
5759:menopausal replacement
5630:of ovariectomy (e.g.,
4276:7α-Methylnorethynodrel
4226:NET; 17α-Ethynyl-19-NT
4126:17α-Methyltestosterone
3922:Dehydroepiandrosterone
3879:0.01 (<0.001–0.05)
3876:DHT; 5α-Androstanolone
3800:0.01 (<0.001–0.02)
3038:8β-Vinyl-17β-estradiol
2963:16α-Iodo-17β-estradiol
2763:6720-CDRI; NNC-460,020
2484:Triphenylbromoethylene
2238:EE; 17α-Ethynyl-17β-E2
1985:Estrone 3-methyl ether
1956:Estradiol 17β-benzoate
1910:E1S; Estrone 3-sulfate
1162:subcutaneous injection
971:to offset the risk of
857:. However, estrone is
14279:Miproxifene phosphate
14104:27-Hydroxycholesterol
13568:Triphenyliodoethylene
13112:Ethinylandrostenediol
13075:Estrogenic substances
13063:Polyestriol phosphate
12931:Cloxestradiol acetate
12414:chlormadinone acetate
11798:Estrogenic substances
11792:polyestriol phosphate
11692:Cloxestradiol acetate
10822:10.1677/joe.0.0160202
10477:10.1210/jcem-62-3-536
10353:10.1124/pr.114.009712
9964:Environ. Sci. Technol
9512:10.1210/jcem-1-12-983
9429:10.1186/1471-227X-7-7
9366:Int J Gynaecol Obstet
8949:"Enforcement Reports"
8876:"Estrone - Drugs.com"
8183:Estrogenic substances
7889:mixtures of estrogens
7529:biological half-lives
6808:maturation dosage of
6767:50 ≈ 30 d; 80 ≈ 60 d
6754:Polyestriol phosphate
6696:40 ≈ 30 d; 80 ≈ 60 d;
6643:Estradiol dienanthate
6269:= Clinical relief of
6256:Sources and footnotes
5592:biological properties
764:) and in the form of
739:injection into muscle
13593:WAY-204688 (SIM-688)
13405:ERB-196 (WAY-202196)
13356:Dienestrol diacetate
13095:Estrone methyl ether
13001:Esterified estrogens
12943:Conjugated estrogens
12836:17β-Dihydroequilenin
12811:17α-Dihydroequilenin
12751:15α-Hydroxyestradiol
12746:11β-Methoxyestradiol
12721:8,9-Dehydroestradiol
12422:gestonorone caproate
12236:Aromatase inhibitors
11919:Dienestrol diacetate
11867:Prasterone enanthate
11752:estradiol undecylate
11717:Esterified estrogens
11702:Conjugated estrogens
11280:10.1210/jcem-6-6-420
10680:Expert Opin Ther Pat
10656:10.1210/jcem-56-1-76
10386:Ann. N. Y. Acad. Sci
9927:10.1289/ehp.97105734
9593:10.1210/jcem-12-1-28
9461:McDonnell K (1986).
8983:AMA drug evaluations
8293:. pp. 341–354.
8178:Estrone/progesterone
8143:(Estratab, Menest).
8141:esterified estrogens
8137:conjugated estrogens
7018:conjugated estrogens
6822:estradiol undecylate
6662:Estradiol undecylate
6107:Conjugated estrogens
4389:estradiol and human
4251:5(10)-Norethisterone
4176:17α-Ethynyl-3β-adiol
4151:17α-Ethynyl-3α-adiol
3063:ERB-041; WAY-202,041
2159:17α-Dihydroequilenin
2134:17β-Dihydroequilenin
2063:6,8-Didehydroestrone
1981:Estrone methyl ether
1335:E1; 17-Ketoestradiol
1012:Estrone/progesterone
893:in the treatment of
782:conjugated estrogens
750:inside of the vagina
41:Estrone (medication)
14760:Propylpyrazoletriol
14675:Diarylpropionitrile
13523:Propylpyrazoletriol
13380:Dimethylstilbestrol
13346:Diarylpropionitrile
13156:Etynodiol diacetate
12856:Abiraterone acetate
12766:16α-Fluoroestradiol
12418:cyproterone acetate
12317:testosterone esters
11748:estradiol enanthate
11744:estradiol cypionate
11677:etynodiol diacetate
11646:testosterone esters
10398:2005NYASA1057..506W
10154:Gynecol. Endocrinol
9976:2002EnST...36.4410L
9544:California Medicine
8520:"Endocrine Testing"
7977:Society and culture
7913:British Drug Houses
7803:estrone glucuronide
7723:naturally occurring
7589:estrone glucuronide
7581:estrogen conjugates
7454:estrone glucuronide
7446:estrogen conjugates
7148:Estrone glucuronide
6784:aqueous suspensions
6624:Estradiol enanthate
6591:Estradiol cypionate
6393:
5919:Tooltip Cholesterol
5860:Tooltip Hot flashes
5847:
5795:menopausal symptoms
5783:luteinizing hormone
5739:oral administration
5737:of estradiol. With
5720:vaginal lubrication
5688:aching and soreness
5628:subjective symptoms
5553:Luteinizing hormone
5048:
4987:dihydrotestosterone
4434:
4401:See template page.
4201:P4; 4-Pregnenedione
4001:A4; Androstenedione
3872:Dihydrotestosterone
3854:<0.0001–<0.01
3851:T; 4-Androstenolone
3669:0.135 (0.002–4.23)
3666:0.0315 (0.008–1.0)
3269:0.6225 (0.010–1.2)
3244:0.7865 (0.04–17.1)
3113:SERBA-1; LY-500,307
3009:Diarylpropionitrile
2909:Propylpyrazoletriol
1806:Estradiol disulfate
1252:
1199:of estradiol. Some
1156:. It is a far less
1136:Mechanism of action
1022:aqueous suspensions
992:surgical castration
984:menopausal symptoms
899:low estrogen levels
820:naturally occurring
720:naturally occurring
289:Estrone glucuronide
43:
27:Estrogen medication
14842:Diethylstilbestrol
14626:2-Methoxyestradiol
14557:TAS-108 (SR-16234)
14507:Methylepitiostanol
14445:EM-800 (SCH-57050)
14369:TAS-108 (SR-16234)
14089:2-Phenylbenzofuran
13703:8-prenylnaringenin
13363:Diethylstilbestrol
13021:Lipoidal estradiol
12996:ERA-63 (ORG-37663)
12938:Conjugated estriol
12883:methyltestosterone
12841:17β-Dihydroequilin
12816:17α-Dihydroequilin
12791:16β-Hydroxyestrone
12776:16α-Hydroxyestrone
12726:8,9-Dehydroestrone
12711:7α-Methylestradiol
12686:4-Methoxyestradiol
12676:4-Hydroxyestradiol
12651:3β-Hydroxytibolone
12646:3α-Hydroxytibolone
12616:2-Hydroxyestradiol
12513:Never to phase III
12348:releasers) (e.g.,
12259:Second-generation:
11872:Prasterone sulfate
11756:estradiol valerate
11740:estradiol benzoate
11697:Conjugated estriol
11650:methyltestosterone
10612:10.7812/TPP/98.930
9844:Biochem. Pharmacol
9036:Rivlin ME (1990).
7967:aqueous suspension
7538:aqueous suspension
7474:catechol estrogens
7464:, and can also be
7429:See template page.
7372:metabolic pathways
7191:16α-Hydroxyestrone
7113:Metabolic pathways
7068:(SHBG) and 80% to
7026:diethylstilbestrol
6988:See template page.
6923:estradiol pivalate
6900:vaginal epithelial
6896:aqueous suspension
6814:estradiol valerate
6810:estradiol benzoate
6551:Estradiol valerate
6485:Estradiol benzoate
6364:
6283:vaginal epithelium
6218:Diethylstilbestrol
5820:
5706:of the cervix and
5692:Reproductive tract
5682:within the breast
5640:reproductive tract
5527:estrogen receptors
5446:16α-Hydroxyestrone
5314:4-Methoxyestradiol
5292:4-Hydroxyestradiol
5270:2-Methoxyestradiol
5248:2-Hydroxyestradiol
5021:
4886:Diethylstilbestrol
4580:Estradiol valerate
4552:Estradiol benzoate
4407:
4347:3β-Hydroxytibolone
4322:3α-Hydroxytibolone
4122:Methyltestosterone
4101:5β-Androstanedione
4076:5α-Androstanedione
3951:A5; Androstenediol
3691:<0.001–<0.01
3334:8-Prenylnaringenin
3291:0.07 (0.029–0.10)
3266:0.04 (0.022–0.15)
3241:0.07 (0.0018–9.3)
3191:0.445 (0.0012–16)
3169:64.125 (0.41–185)
3166:9.225 (0.0117–94)
2894:21.65 (2.05–40.5)
2388:Dehydrostilbestrol
2344:219.63 (61.2–295)
2334:Diethylstilbestrol
2213:8,9-Dehydroestrone
2109:17α-Dihydroequilin
2084:17β-Dihydroequilin
1931:Estradiol benzoate
1706:16α-Hydroxyestrone
1581:4-Methoxyestradiol
1556:4-Hydroxyestradiol
1531:2-Methoxyestradiol
1506:2-Hydroxyestradiol
1321:0.115 (0.04–0.24)
1223:
1146:estrogen receptors
1100:breast enlargement
923:high-dose estrogen
800:breast enlargement
731:aqueous suspension
39:
14895:
14894:
14887:List of estrogens
14855:
14854:
14600:
14599:
14440:Cytestrol acetate
13663:isoliquiritigenin
13605:Unknown/unsorted:
13291:β-LGND2 (GTx-878)
12871:Anabolic steroids
12781:16α-Iodoestradiol
12671:4-Fluoroestradiol
12666:4-Androstenedione
12656:3β-Androstanediol
12631:3α-Androstanediol
12582:Estrogen receptor
12548:
12547:
12540:List of estrogens
12482:
12481:
12434:megestrol acetate
12321:nandrolone esters
12309:anabolic steroids
12297:Antigonadotropins
12274:Third-generation:
12247:Aminoglutethimide
12244:First-generation:
12082:
12081:
11788:estriol succinate
11736:estradiol acetate
11658:nandrolone esters
11638:anabolic steroids
11529:(Suppl 1): 3–63.
11506:978-3-642-60107-1
11372:978-0-913595-15-2
11345:978-1-351-74347-1
11318:978-92-832-1221-8
11308:Sex Hormones (II)
11217:978-0-521-04394-6
11068:978-3-319-28914-4
11041:978-3-527-32669-3
11011:978-1-4613-2157-6
10934:10.1002/ijc.23350
10897:978-1-56363-429-1
10777:10.1172/JCI103524
10745:978-3-642-49477-2
10510:(5128): 1029–31.
10091:978-1-4200-5873-4
9984:10.1021/es010323a
9895:978-3-642-96158-8
9474:978-967-9973-17-4
9347:978-0-85369-840-1
9322:978-0-444-51830-9
9295:978-0-521-43623-6
9266:978-81-250-0910-8
9206:978-94-011-7230-1
9172:978-3-662-40303-7
9124:978-0-7817-1750-2
9049:978-0-316-74772-1
9022:978-1-4684-5036-1
8993:978-0-88416-175-2
8929:978-1-4684-5036-1
8848:978-0-8018-8602-7
8764:978-0-465-07259-0
8730:978-94-011-7232-5
8692:978-1-4612-5525-3
8656:978-94-011-4439-1
8622:978-3-88763-075-1
8575:978-1-4757-2085-3
8533:978-1-4557-1126-0
8501:978-0-07-105406-5
8450:(Suppl 1): 3–63.
8342:978-0-7817-5734-8
8327:Vuong LK (2006).
8308:978-3-319-13831-2
8226:978-0-85369-840-1
7807:estrone sulfamate
7719:
7718:
7458:sulfotransferases
7436:
7435:
6834:
6833:
6775:Notes and sources
6677:25–50 ≈ 60–120 d
6362:
6361:
6315:= Suppression of
6302:= Suppression of
5745:circumstances in
5716:needle-like pains
5698:, thickness, and
5684:mammary glandular
5584:clinical research
5575:
5574:
5336:4-Fluoroestradiol
5019:
5018:
4405:
4404:
4047:3β-Androstanediol
4022:3α-Androstanediol
3997:4-Androstenedione
3619:9.45 (2.43–31.5)
3319:0.15 (0.11–0.33)
3294:2.2 (0.002–3.00)
3219:0.85 (0.10–2.85)
2866:63.5 (3.70–97.7)
2459:Triphenylethylene
2341:129.5 (89.1–468)
2263:EE 3-methyl ether
2241:120.9 (68.8–480)
1781:Estradiol sulfate
1360:E3; 16α-OH-17β-E2
1347:1.75 (0.35–9.24)
1344:0.445 (0.3–1.01)
1324:0.15 (0.10–2.08)
1312:E2; 17β-Estradiol
1096:breast tenderness
836:biological target
832:estrogen receptor
796:breast tenderness
693:
692:
617:Interactive image
190:
16:(Redirected from
14945:
14754:2,2',5'-PCB-4-OH
14690:Ethinylestradiol
14616:
14615:
14612:
14608:
14349:Rimostil (P-081)
14159:Chlorotrianisene
14081:
14077:
13856:Metalloestrogens
13635:-related (e.g.,
13450:Hexestrol esters
13124:Ethinylestradiol
13016:Estradiol esters
12771:16α-Hydroxy-DHEA
12756:16-Ketoestradiol
12696:5-Androstenediol
12691:4-Methoxyestrone
12681:4-Hydroxyestrone
12661:4-Androstenediol
12621:2-Hydroxyestrone
12603:
12602:
12599:
12595:
12575:
12568:
12561:
12552:
12551:
12395:
12378:
12123:
12119:
12114:
12110:
12103:
12099:
12093:
12092:
12074:
12070:
12065:
12061:
12044:
12037:
12017:Progonadotropins
11963:Hexestrol esters
11909:Chlorotrianisene
11825:Ethinylestradiol
11732:Estradiol esters
11617:
11613:
11607:
11606:
11583:
11576:
11569:
11560:
11559:
11554:
11520:
11510:
11479:
11478:
11461:(6676): 229–32.
11450:
11444:
11443:
11433:
11416:(4034): 939–41.
11401:
11395:
11394:
11383:
11377:
11376:
11356:
11350:
11349:
11329:
11323:
11322:
11302:
11296:
11295:
11263:
11257:
11256:
11228:
11222:
11221:
11201:
11195:
11194:
11184:
11160:
11149:
11148:
11120:
11111:
11110:
11082:
11076:
11075:
11052:
11046:
11045:
11025:
11016:
11015:
10993:
10987:
10986:
10958:
10947:
10946:
10936:
10927:(9): 1931–1940.
10912:
10906:
10905:
10881:
10875:
10874:
10864:
10840:
10834:
10833:
10805:
10799:
10798:
10788:
10771:(8): 1266–1278.
10756:
10750:
10749:
10723:
10712:
10711:
10675:
10669:
10668:
10658:
10634:
10628:
10627:
10597:
10588:
10582:
10581:
10571:
10547:
10541:
10540:
10527:
10500:"The oestrogens"
10495:
10489:
10488:
10459:
10453:
10452:
10432:
10426:
10425:
10381:
10375:
10374:
10364:
10332:
10326:
10325:
10297:
10284:
10283:
10254:
10239:
10238:
10201:
10186:
10185:
10149:
10140:
10139:
10129:
10105:
10096:
10095:
10075:
10066:
10065:
10037:
10031:
10030:
10002:
9996:
9995:
9955:
9949:
9948:
9938:
9906:
9900:
9899:
9877:
9868:
9867:
9838:
9827:
9826:
9798:
9779:
9778:
9750:
9731:
9730:
9705:(9): 1142–1143.
9694:
9675:
9674:
9646:
9640:
9639:
9611:
9605:
9604:
9576:
9570:
9569:
9559:
9535:
9524:
9523:
9495:
9482:
9481:
9458:
9452:
9451:
9441:
9431:
9407:
9401:
9400:
9361:
9355:
9354:
9333:
9327:
9326:
9306:
9300:
9299:
9277:
9271:
9270:
9248:
9242:
9241:
9235:
9227:
9217:
9211:
9210:
9188:
9177:
9176:
9154:
9145:
9140:
9129:
9128:
9106:
9100:
9099:
9071:
9058:
9057:
9033:
9027:
9026:
9004:
8998:
8997:
8976:
8970:
8969:
8962:
8956:
8955:
8953:
8945:
8934:
8933:
8903:
8892:
8891:
8889:
8887:
8878:. Archived from
8872:
8853:
8852:
8832:
8823:
8822:
8812:
8788:
8773:
8772:
8748:
8735:
8734:
8708:
8697:
8696:
8674:
8661:
8660:
8640:
8627:
8626:
8607:
8580:
8579:
8559:
8538:
8537:
8515:
8506:
8505:
8485:
8476:
8475:
8441:
8432:
8347:
8346:
8324:
8313:
8312:
8286:
8273:
8272:
8246:
8231:
8230:
8210:
8139:(Premarin), and
8063:
8059:
8050:
8046:
8041:
8037:
8032:
8028:
8023:
8019:
8014:
8010:
8005:
8001:
7995:American English
7945:aqueous solution
7795:estrone benzoate
7702:
7701:
7691:
7683:
7675:
7667:
7660:
7659:
7647:
7640:
7633:
7621:
7482:4-hydroxyestrone
7478:2-hydroxyestrone
7374:involved in the
7365:
7364:
7354:
7349:
7347:
7340:
7329:
7327:
7320:
7318:
7311:
7309:
7296:
7294:
7287:
7285:
7272:
7270:
7264:
7257:
7255:
7248:
7246:
7239:
7237:
7224:
7217:
7210:
7200:
7198:4-Methoxyestrone
7193:
7186:
7184:2-Methoxyestrone
7176:
7174:4-Hydroxyestrone
7169:
7160:
7158:2-Hydroxyestrone
7150:
7143:
7136:
7127:
7126:
7107:
7100:
7093:
7081:
7042:pharmacokinetics
7022:ethinylestradiol
6996:Pharmacokinetics
6970:aqueous solution
6964:of 0.10 μg
6942:
6914:
6876:
6859:
6852:
6845:
6788:microcrystalline
6675:10–20 ≈ 40–60 d;
6418:
6413:
6394:
6392:
6385:
6378:
6371:
6363:
6343:
6339:
6335:
6331:
6327:
6323:
6319:
6314:
6310:
6306:
6301:
6297:
6293:
6288:
6276:
6268:
6181:Ethinylestradiol
5955:
5950:
5946:
5940:
5936:
5930:
5926:
5920:
5916:
5911:
5907:
5901:
5897:
5891:
5887:
5881:
5877:
5871:
5867:
5861:
5857:
5848:
5841:
5834:
5827:
5819:
5793:, and relief of
5763:follicular phase
5735:inactive prodrug
5724:uterine bleeding
5708:mucous discharge
5690:of the breasts.
5550:
5520:
5517:
5490:2-Methoxyestriol
5468:2-Hydroxyestriol
5424:4-Methoxyestrone
5402:4-Hydroxyestrone
5380:2-Methoxyestrone
5358:2-Hydroxyestrone
5113:
5109:
5105:
5101:
5094:
5090:
5072:
5068:
5064:
5060:
5049:
5042:
5035:
5028:
5020:
5010:
5006:
4997:
4993:
4984:
4980:
4971:
4967:
4958:
4954:
4945:
4941:
4932:
4928:
4774:Ethinylestradiol
4518:
4514:
4508:
4504:
4498:
4494:
4488:
4484:
4478:
4474:
4468:
4464:
4458:
4454:
4435:
4428:
4421:
4414:
4406:
4376:Binding affinity
4097:Etiocholanedione
3972:4-Androstenediol
3947:5-Androstenediol
3926:DHEA; Prasterone
3491:<0.001–0.0032
3466:<0.001–0.0875
3194:33.42 (0.86–87)
2541:100.1 (1.7–257)
2434:Chlorotrianisene
2338:DES; Stilbestrol
2234:Ethinylestradiol
2038:7-Dehydroestrone
1756:4-Methoxyestriol
1731:2-Hydroxyestriol
1681:4-Methoxyestrone
1656:4-Hydroxyestrone
1631:2-Methoxyestrone
1606:2-Hydroxyestrone
1481:16,17-Epiestriol
1438:7.795 (4.94–63)
1369:0.45 (0.35–1.4)
1363:12.65 (4.03–56)
1253:
1251:
1244:
1237:
1230:
1222:
1131:Pharmacodynamics
939:pharmacokinetics
919:antigonadotropin
826:estrogen, or an
689:
688:
619:
599:
584:
578:
572:
552:
532:
512:
492:
472:
452:
432:
412:
402:
401:
387:
312:
308:
301:
242:• Free: 2.0–4.0%
239:
188:
185:
163:
152:
114:
110:
60:
51:
44:
42:
38:
21:
14953:
14952:
14948:
14947:
14946:
14944:
14943:
14942:
14908:Abandoned drugs
14898:
14897:
14896:
14891:
14851:
14830:
14794:
14610:
14596:
14430:7β-Hydroxy-DHEA
14413:
14249:Levormeloxifene
14079:
14072:
14066:
13982:deoxymiroestrol
13850:-hinokiresinol)
13488:Methallenestril
13390:Doisynolic acid
13191:Methylestradiol
12706:7α-Hydroxy-DHEA
12597:
12587:
12579:
12549:
12544:
12518:
12503:Clinical trials
12478:
12439:
12338:
12329:fluoxymesterone
12291:
12230:
12121:
12112:
12105:
12101:
12078:
12072:
12063:
12011:
11970:Methallenestril
11847:Methylestradiol
11813:Estrone sulfate
11615:
11596:
11587:
11557:
11518:
11514:Kuhl H (2005).
11507:
11488:
11486:Further reading
11483:
11482:
11451:
11447:
11402:
11398:
11385:
11384:
11380:
11373:
11357:
11353:
11346:
11330:
11326:
11319:
11303:
11299:
11264:
11260:
11229:
11225:
11218:
11202:
11198:
11175:(11): 680–695.
11161:
11152:
11121:
11114:
11083:
11079:
11069:
11053:
11049:
11042:
11026:
11019:
11012:
10994:
10990:
10959:
10950:
10913:
10909:
10898:
10882:
10878:
10841:
10837:
10806:
10802:
10757:
10753:
10746:
10724:
10715:
10676:
10672:
10635:
10631:
10595:
10589:
10585:
10548:
10544:
10496:
10492:
10460:
10456:
10433:
10429:
10382:
10378:
10333:
10329:
10302:Acta Endocrinol
10298:
10287:
10266:(8): 1099–106.
10255:
10242:
10202:
10189:
10150:
10143:
10120:(13): 8118–22.
10106:
10099:
10092:
10076:
10069:
10038:
10034:
10003:
9999:
9956:
9952:
9907:
9903:
9896:
9878:
9871:
9850:(10): 1459–69.
9839:
9830:
9799:
9782:
9751:
9734:
9695:
9678:
9647:
9643:
9612:
9608:
9577:
9573:
9536:
9527:
9506:(12): 983–985.
9496:
9485:
9475:
9459:
9455:
9408:
9404:
9362:
9358:
9348:
9334:
9330:
9323:
9307:
9303:
9296:
9278:
9274:
9267:
9249:
9245:
9229:
9228:
9218:
9214:
9207:
9189:
9180:
9173:
9155:
9148:
9141:
9132:
9125:
9107:
9103:
9072:
9061:
9050:
9034:
9030:
9023:
9005:
9001:
8994:
8977:
8973:
8964:
8963:
8959:
8951:
8947:
8946:
8937:
8930:
8904:
8895:
8885:
8883:
8882:on 21 June 2018
8874:
8873:
8856:
8849:
8833:
8826:
8789:
8776:
8765:
8749:
8738:
8731:
8709:
8700:
8693:
8675:
8664:
8657:
8641:
8630:
8623:
8609:
8608:
8583:
8576:
8560:
8541:
8534:
8516:
8509:
8502:
8486:
8479:
8439:
8435:Kuhl H (2005).
8433:
8350:
8343:
8325:
8316:
8309:
8287:
8276:
8269:
8247:
8234:
8227:
8211:
8196:
8191:
8169:
8149:
8129:estrone sulfate
8109:
8095:
8078:
8066:British English
8061:
8048:
8039:
8030:
8021:
8012:
8003:
7984:
7979:
7829:Selmar Aschheim
7825:Bernhard Zondek
7821:
7815:
7799:estrone cyanate
7783:estrone sulfate
7779:estrone acetate
7715:
7714:
7713:
7703:
7695:
7694:
7693:
7692:
7686:
7684:
7678:
7676:
7670:
7668:
7665:
7661:
7657:
7653:
7651:
7619:
7609:
7585:estrone sulfate
7579:in the form of
7569:
7470:cytochrome P450
7450:estrone sulfate
7439:
7437:
7432:
7431:
7430:
7411:glucuronidation
7366:
7358:
7357:
7356:
7355:
7352:
7350:
7345:
7343:
7341:
7338:
7335:
7332:
7330:
7325:
7323:
7321:
7316:
7314:
7312:
7307:
7305:
7302:
7299:
7297:
7292:
7290:
7288:
7283:
7281:
7278:
7275:
7273:
7268:
7266:
7262:
7260:
7258:
7253:
7251:
7249:
7244:
7242:
7240:
7235:
7233:
7230:
7227:
7225:
7220:
7218:
7213:
7211:
7206:
7203:
7201:
7196:
7194:
7189:
7187:
7182:
7179:
7177:
7172:
7170:
7163:
7161:
7156:
7153:
7151:
7146:
7144:
7141:Estrone sulfate
7139:
7137:
7132:
7128:
7124:
7120:
7111:
7078:
7054:
7024:, or 1 mg
7010:bioavailability
7003:
6998:
6993:
6992:
6991:
6990:
6989:
6981:
6980:
6977:
6943:
6934:
6917:Mean change in
6915:
6906:
6877:
6866:
6865:
6863:
6830:
6829:
6799:menstrual cycle
6777:
6697:
6676:
6656:7.5 ≈ >40 d
6565:
6390:
6389:
6358:
6357:
6321:
6308:
6295:
6257:
6144:Equilin sulfate
6070:Estrone sulfate
5948:
5938:
5928:
5918:
5909:
5899:
5889:
5879:
5869:
5859:
5845:
5791:bone resorption
5767:first trimester
5749:women and with
5700:differentiation
5676:nipple erection
5662:and a sense of
5624:vaginal dryness
5580:
5111:
5103:
5092:
5070:
5062:
5046:
5008:
4995:
4982:
4969:
4956:
4943:
4930:
4830:Methylestradiol
4634:Estrone sulfate
4516:
4506:
4496:
4486:
4476:
4466:
4456:
4432:
4354:1.6 (0.75–1.9)
4329:2.5 (1.06–5.0)
4279:0.5 (0.45–2.0)
4232:0.1 (0.01–0.3)
4207:<0.001–0.010
4072:Androstanedione
3857:<0.002–0.040
3616:7.68 (2.04–28)
3541:0.6 (0.032–13)
3469:<0.001–0.016
3434:Deoxymiroestrol
3003:ERα antagonist
2916:49 (10.0–89.1)
2891:43.5 (9.4–325)
2759:Levormeloxifene
2669:5.34 (0.54–16)
2613:F-6066; Sexovid
2591:25 (19.2–37.2)
2547:2.3 (0.1–3.61)
2409:Benzestrol (B2)
2366:153.6 (31–302)
2309:Methylestradiol
2244:44.4 (2.0–144)
1906:Estrone sulfate
1638:<0.001–<1
1463:55.45 (29–103)
1372:0.7 (0.63–0.7)
1366:26 (14.0–44.6)
1338:16.39 (0.7–60)
1276:
1249:
1248:
1193:estrone sulfate
1138:
1133:
1128:
1112:fluid retention
1089:
1083:
1014:
1004:
1002:Available forms
946:bioavailability
927:prostate cancer
907:vaginal atrophy
879:
812:fluid retention
774:estrone sulfate
723:steroid hormone
718:medication and
684:
682:
677:
674:
669:
664:
663:
652:
649:
644:
643:
622:
597:
587:
581:
575:
555:
535:
515:
495:
475:
455:
435:
415:
398:
390:
370:
367:
342:
341:
313:: 20–30 minutes
310:
299:
291:
286:
284:Estrone sulfate
281:
265:glucuronidation
241:
235:
229:
224:Protein binding
211:Bioavailability
203:Pharmacokinetic
197:
167:
154:
117:estrone sulfate
112:
90:
35:
28:
23:
22:
15:
12:
11:
5:
14951:
14941:
14940:
14935:
14930:
14925:
14920:
14915:
14910:
14893:
14892:
14890:
14889:
14884:
14879:
14874:
14869:
14864:
14860:
14857:
14856:
14853:
14852:
14850:
14849:
14844:
14838:
14836:
14832:
14831:
14829:
14828:
14823:
14818:
14813:
14808:
14802:
14800:
14796:
14795:
14793:
14792:
14787:
14782:
14777:
14772:
14767:
14762:
14757:
14747:
14742:
14737:
14732:
14727:
14722:
14720:Hydroxytyrosol
14717:
14712:
14707:
14702:
14697:
14692:
14687:
14682:
14677:
14672:
14658:
14653:
14648:
14643:
14638:
14633:
14628:
14622:
14620:
14613:
14602:
14601:
14598:
14597:
14595:
14594:
14585:
14584:
14575:
14574:
14569:
14564:
14559:
14554:
14549:
14544:
14539:
14534:
14529:
14524:
14519:
14514:
14509:
14504:
14499:
14494:
14489:
14467:
14462:
14457:
14452:
14447:
14442:
14437:
14435:Chloroindazole
14432:
14427:
14421:
14419:
14415:
14414:
14412:
14411:
14406:
14401:
14396:
14391:
14386:
14381:
14376:
14371:
14366:
14361:
14356:
14354:Spironolactone
14351:
14346:
14341:
14336:
14331:
14326:
14321:
14316:
14311:
14306:
14301:
14296:
14291:
14286:
14281:
14276:
14271:
14266:
14261:
14256:
14251:
14246:
14241:
14236:
14231:
14226:
14221:
14216:
14211:
14206:
14201:
14196:
14191:
14186:
14181:
14176:
14171:
14166:
14161:
14156:
14151:
14146:
14141:
14136:
14131:
14126:
14121:
14116:
14111:
14106:
14101:
14096:
14091:
14085:
14083:
14068:
14067:
14065:
14064:
14055:Others (e.g.,
14053:
14003:
13989:
13975:
13945:
13927:
13905:
13863:
13853:
13831:
13826:
13783:liquiritigenin
13692:
13678:
13656:
13630:Xenoestrogens:
13626:
13625:
13620:
13615:
13610:
13601:
13600:
13595:
13590:
13585:
13580:
13575:
13570:
13565:
13560:
13555:
13550:
13545:
13540:
13535:
13530:
13525:
13520:
13515:
13510:
13505:
13503:Paroxypropione
13500:
13495:
13490:
13485:
13480:
13472:
13464:
13459:
13454:
13453:
13452:
13442:
13437:
13432:
13427:
13422:
13417:
13415:Estrobin (DBE)
13412:
13407:
13402:
13397:
13392:
13387:
13382:
13377:
13372:
13371:
13370:
13360:
13359:
13358:
13348:
13343:
13338:
13333:
13328:
13323:
13318:
13313:
13308:
13306:Allenolic acid
13303:
13298:
13293:
13288:
13283:
13278:
13273:
13264:
13263:
13258:
13253:
13248:
13243:
13238:
13233:
13228:
13223:
13218:
13213:
13211:Norethisterone
13208:
13203:
13201:Mytatrienediol
13198:
13193:
13188:
13183:
13178:
13173:
13168:
13163:
13158:
13153:
13148:
13146:Ethylestradiol
13143:
13141:Ethinylestriol
13138:
13137:
13136:
13131:
13121:
13120:
13119:
13109:
13104:
13103:
13102:
13097:
13092:
13090:Estrone esters
13082:
13077:
13072:
13067:
13066:
13065:
13060:
13058:Estriol esters
13050:
13045:
13043:Estrapronicate
13040:
13035:
13030:
13029:
13028:
13023:
13018:
13008:
13003:
12998:
12993:
12988:
12983:
12978:
12973:
12965:
12960:
12955:
12950:
12945:
12940:
12935:
12934:
12933:
12923:
12918:
12913:
12908:
12903:
12898:
12868:
12863:
12861:Alestramustine
12858:
12853:
12848:
12843:
12838:
12833:
12828:
12823:
12818:
12813:
12808:
12798:
12793:
12788:
12783:
12778:
12773:
12768:
12763:
12761:16-Ketoestrone
12758:
12753:
12748:
12743:
12738:
12733:
12728:
12723:
12718:
12713:
12708:
12703:
12698:
12693:
12688:
12683:
12678:
12673:
12668:
12663:
12658:
12653:
12648:
12643:
12638:
12633:
12628:
12623:
12618:
12609:
12607:
12600:
12589:
12588:
12578:
12577:
12570:
12563:
12555:
12546:
12545:
12543:
12542:
12537:
12532:
12527:
12522:
12517:
12516:
12515:
12514:
12511:
12500:
12494:
12488:
12487:
12484:
12483:
12480:
12479:
12477:
12476:
12471:
12462:
12461:
12456:
12447:
12445:
12441:
12440:
12438:
12437:
12407:
12390:
12373:
12366:chlorpromazine
12354:metoclopramide
12336:
12332:
12301:
12299:
12293:
12292:
12290:
12289:
12284:
12279:
12270:
12269:
12264:
12255:
12254:
12249:
12240:
12238:
12232:
12231:
12229:
12228:
12219:
12218:
12213:
12204:
12203:
12198:
12193:
12188:
12183:
12178:
12173:
12168:
12163:
12158:
12153:
12148:
12143:
12138:
12133:
12127:
12125:
12090:
12084:
12083:
12080:
12079:
12077:
12076:
12052:
12032:
12021:
12019:
12013:
12012:
12010:
12009:
12004:
11999:
11994:
11989:
11987:Paroxypropione
11984:
11983:
11982:
11972:
11967:
11966:
11965:
11955:
11950:
11949:
11948:
11943:
11938:
11928:
11923:
11922:
11921:
11911:
11906:
11901:
11892:
11891:
11886:
11881:
11876:
11875:
11874:
11869:
11859:
11854:
11849:
11844:
11839:
11834:
11833:
11832:
11822:
11821:
11820:
11815:
11808:Estrone esters
11805:
11800:
11795:
11784:Estriol esters
11781:
11776:
11771:
11729:
11724:
11719:
11714:
11709:
11704:
11699:
11694:
11689:
11684:
11669:norethisterone
11661:
11630:
11621:
11619:
11604:
11598:
11597:
11586:
11585:
11578:
11571:
11563:
11556:
11555:
11511:
11505:
11489:
11487:
11484:
11481:
11480:
11445:
11396:
11378:
11371:
11351:
11344:
11324:
11317:
11297:
11274:(6): 420–422.
11258:
11223:
11216:
11196:
11150:
11112:
11077:
11067:
11047:
11040:
11017:
11010:
10988:
10948:
10907:
10896:
10876:
10855:(1): 335–349.
10835:
10816:(2): 202–212.
10800:
10751:
10744:
10713:
10686:(9): 1123–45.
10670:
10629:
10583:
10562:(10): 1063–6.
10556:Fertil. Steril
10542:
10490:
10454:
10437:Altern Med Rev
10427:
10376:
10341:Pharmacol. Rev
10327:
10285:
10240:
10187:
10141:
10097:
10090:
10067:
10032:
9997:
9970:(20): 4410–5.
9950:
9901:
9894:
9869:
9828:
9780:
9732:
9676:
9657:(6): 334–336.
9641:
9606:
9571:
9550:(6): 277–278.
9525:
9483:
9473:
9453:
9402:
9356:
9346:
9328:
9321:
9301:
9294:
9282:"Osteoporosis"
9272:
9265:
9243:
9212:
9205:
9178:
9171:
9146:
9130:
9123:
9101:
9059:
9048:
9028:
9021:
8999:
8992:
8971:
8957:
8935:
8928:
8893:
8854:
8847:
8824:
8803:(5): 362–366.
8774:
8763:
8736:
8729:
8698:
8691:
8662:
8655:
8628:
8621:
8581:
8574:
8539:
8532:
8507:
8500:
8477:
8348:
8341:
8314:
8307:
8274:
8267:
8232:
8225:
8193:
8192:
8190:
8187:
8186:
8185:
8180:
8175:
8168:
8165:
8148:
8145:
8094:
8091:
8077:
8074:
7993:of estrone in
7983:
7980:
7978:
7975:
7885:amniotic fluid
7814:
7811:
7771:estrone esters
7737:hydroxyl group
7717:
7716:
7697:
7696:
7663:
7662:
7655:
7654:
7650:
7649:
7642:
7635:
7627:
7626:
7625:
7624:
7608:
7605:
7568:
7565:
7462:glucuronidases
7434:
7433:
7360:
7359:
7130:
7129:
7122:
7121:
7110:
7109:
7102:
7095:
7087:
7086:
7085:
7084:
7079:
7077:
7074:
7060:. In terms of
7053:
7050:
7002:
6999:
6997:
6994:
6984:
6983:
6982:
6979:
6978:
6944:
6937:
6935:
6916:
6909:
6907:
6890:of estrone or
6878:
6871:
6868:
6867:
6862:
6861:
6854:
6847:
6839:
6838:
6837:
6836:
6835:
6832:
6831:
6778:
6773:
6772:
6769:
6768:
6765:
6762:
6759:
6756:
6750:
6749:
6746:
6743:
6740:
6737:
6731:
6730:
6729:0.1–2 ≈ 2–7 d
6727:
6724:
6721:
6717:
6716:
6713:
6710:
6707:
6704:
6700:
6699:
6694:
6691:
6688:
6685:
6679:
6678:
6673:
6670:
6667:
6664:
6658:
6657:
6654:
6651:
6648:
6645:
6639:
6638:
6635:
6632:
6629:
6626:
6620:
6619:
6616:
6613:
6610:
6606:
6605:
6602:
6599:
6596:
6593:
6587:
6586:
6583:
6580:
6577:
6574:
6568:
6567:
6562:
6559:
6556:
6553:
6547:
6546:
6543:
6540:
6537:
6534:
6528:
6527:
6524:
6521:
6518:
6514:
6513:
6510:
6507:
6504:
6500:
6499:
6496:
6493:
6490:
6487:
6481:
6480:
6477:
6474:
6471:
6467:
6466:
6463:
6460:
6457:
6453:
6452:
6449:
6446:
6443:
6439:
6438:
6435:
6432:
6429:
6426:
6420:
6419:
6414:
6408:
6407:
6404:
6401:
6398:
6388:
6387:
6380:
6373:
6365:
6360:
6359:
6346:liver proteins
6289:= Decrease in
6264:Abbreviations:
6258:
6255:
6254:
6251:
6250:
6247:
6244:
6241:
6238:
6235:
6232:
6229:
6226:
6223:
6220:
6214:
6213:
6210:
6207:
6204:
6201:
6198:
6195:
6192:
6189:
6186:
6183:
6177:
6176:
6173:
6170:
6167:
6164:
6161:
6158:
6155:
6152:
6149:
6146:
6140:
6139:
6136:
6133:
6130:
6127:
6124:
6121:
6118:
6115:
6112:
6109:
6103:
6102:
6099:
6096:
6093:
6090:
6087:
6084:
6081:
6078:
6075:
6072:
6066:
6065:
6062:
6059:
6056:
6053:
6050:
6047:
6044:
6041:
6038:
6035:
6029:
6028:
6025:
6022:
6019:
6016:
6013:
6010:
6007:
6004:
6001:
5998:
5994:
5993:
5990:
5987:
5984:
5981:
5978:
5975:
5972:
5969:
5966:
5963:
5957:
5956:
5951:
5941:
5931:
5921:
5902:
5892:
5882:
5872:
5862:
5852:
5844:
5843:
5836:
5829:
5821:
5588:ovariectomized
5579:
5576:
5573:
5572:
5571:See template.
5538:ovariectomized
5508:
5507:
5504:
5501:
5498:
5495:
5492:
5486:
5485:
5482:
5479:
5476:
5473:
5470:
5464:
5463:
5460:
5457:
5454:
5451:
5448:
5442:
5441:
5438:
5435:
5432:
5429:
5426:
5420:
5419:
5416:
5413:
5410:
5407:
5404:
5398:
5397:
5394:
5391:
5388:
5385:
5382:
5376:
5375:
5372:
5369:
5366:
5363:
5360:
5354:
5353:
5350:
5347:
5344:
5341:
5338:
5332:
5331:
5328:
5325:
5322:
5319:
5316:
5310:
5309:
5306:
5303:
5300:
5297:
5294:
5288:
5287:
5284:
5281:
5278:
5275:
5272:
5266:
5265:
5262:
5259:
5256:
5253:
5250:
5244:
5243:
5240:
5237:
5234:
5231:
5228:
5222:
5221:
5218:
5215:
5212:
5209:
5206:
5200:
5199:
5196:
5193:
5190:
5187:
5184:
5178:
5177:
5174:
5171:
5168:
5165:
5162:
5158:
5157:
5154:
5151:
5148:
5145:
5142:
5140:Estradiol (E2)
5136:
5135:
5132:
5129:
5126:
5123:
5120:
5116:
5115:
5096:
5085:
5080:
5077:Uterine weight
5074:
5055:
5045:
5044:
5037:
5030:
5022:
5017:
5016:
5015:See template.
4910:
4909:
4906:
4903:
4900:
4897:
4894:
4891:
4888:
4882:
4881:
4878:
4875:
4872:
4869:
4866:
4863:
4860:
4854:
4853:
4850:
4847:
4844:
4841:
4838:
4835:
4832:
4826:
4825:
4822:
4819:
4816:
4813:
4810:
4807:
4804:
4798:
4797:
4794:
4791:
4788:
4785:
4782:
4779:
4776:
4770:
4769:
4766:
4763:
4760:
4757:
4754:
4751:
4748:
4742:
4741:
4738:
4735:
4732:
4729:
4726:
4723:
4720:
4714:
4713:
4710:
4707:
4704:
4701:
4698:
4695:
4692:
4686:
4685:
4682:
4679:
4676:
4673:
4670:
4667:
4664:
4658:
4657:
4654:
4651:
4648:
4645:
4642:
4639:
4636:
4630:
4629:
4626:
4623:
4620:
4617:
4614:
4611:
4608:
4604:
4603:
4600:
4597:
4594:
4591:
4588:
4585:
4582:
4576:
4575:
4572:
4569:
4566:
4563:
4560:
4557:
4554:
4548:
4547:
4544:
4541:
4538:
4535:
4532:
4529:
4526:
4520:
4519:
4509:
4499:
4489:
4479:
4469:
4459:
4448:
4447:
4441:
4431:
4430:
4423:
4416:
4408:
4403:
4402:
4368:
4367:
4364:
4361:
4358:
4355:
4352:
4349:
4343:
4342:
4339:
4336:
4333:
4330:
4327:
4324:
4318:
4317:
4314:
4311:
4308:
4305:
4302:
4299:
4293:
4292:
4289:
4286:
4283:
4280:
4277:
4274:
4268:
4267:
4264:
4261:
4258:
4255:
4254:0.5 (0.3–0.7)
4252:
4249:
4243:
4242:
4239:
4236:
4233:
4230:
4227:
4224:
4222:Norethisterone
4218:
4217:
4214:
4211:
4208:
4205:
4202:
4199:
4193:
4192:
4189:
4186:
4183:
4180:
4177:
4174:
4168:
4167:
4164:
4161:
4158:
4155:
4152:
4149:
4143:
4142:
4139:
4136:
4133:
4130:
4127:
4124:
4118:
4117:
4114:
4111:
4108:
4105:
4102:
4099:
4093:
4092:
4089:
4086:
4083:
4080:
4077:
4074:
4068:
4067:
4064:
4061:
4058:
4055:
4052:
4049:
4043:
4042:
4039:
4036:
4033:
4030:
4027:
4024:
4018:
4017:
4014:
4011:
4008:
4005:
4002:
3999:
3993:
3992:
3989:
3986:
3983:
3980:
3977:
3974:
3968:
3967:
3964:
3961:
3958:
3955:
3952:
3949:
3943:
3942:
3939:
3936:
3933:
3930:
3927:
3924:
3918:
3917:
3914:
3911:
3908:
3905:
3902:
3899:
3893:
3892:
3889:
3886:
3883:
3880:
3877:
3874:
3868:
3867:
3864:
3861:
3858:
3855:
3852:
3849:
3843:
3842:
3839:
3836:
3833:
3830:
3827:
3822:Hydroxychlor;
3820:
3814:
3813:
3810:
3807:
3804:
3801:
3798:
3797:-Dimethoxy-DDT
3792:
3786:
3785:
3782:
3779:
3776:
3773:
3770:
3767:
3758:
3757:
3754:
3751:
3748:
3745:
3742:
3739:
3730:
3729:
3726:
3723:
3720:
3717:
3714:
3711:
3705:
3704:
3701:
3698:
3695:
3692:
3689:
3686:
3680:
3679:
3676:
3673:
3670:
3667:
3664:
3661:
3655:
3654:
3651:
3648:
3645:
3642:
3639:
3636:
3630:
3629:
3626:
3623:
3620:
3617:
3614:
3611:
3605:
3604:
3601:
3598:
3595:
3592:
3589:
3586:
3580:
3579:
3576:
3573:
3570:
3567:
3564:
3561:
3555:
3554:
3551:
3548:
3545:
3542:
3539:
3536:
3530:
3529:
3526:
3523:
3520:
3517:
3514:
3511:
3505:
3504:
3501:
3498:
3495:
3492:
3489:
3486:
3480:
3479:
3476:
3473:
3470:
3467:
3464:
3461:
3455:
3454:
3451:
3448:
3445:
3442:
3439:
3436:
3430:
3429:
3426:
3423:
3420:
3417:
3414:
3411:
3405:
3404:
3401:
3398:
3395:
3392:
3389:
3386:
3380:
3379:
3376:
3373:
3370:
3367:
3366:<0.001–0.01
3364:
3361:
3355:
3354:
3351:
3348:
3345:
3342:
3339:
3336:
3330:
3329:
3326:
3323:
3320:
3317:
3314:
3311:
3305:
3304:
3301:
3298:
3295:
3292:
3289:
3286:
3280:
3279:
3276:
3273:
3270:
3267:
3264:
3261:
3255:
3254:
3251:
3248:
3245:
3242:
3239:
3236:
3230:
3229:
3226:
3223:
3220:
3217:
3214:
3211:
3205:
3204:
3201:
3198:
3195:
3192:
3189:
3186:
3180:
3179:
3176:
3173:
3170:
3167:
3164:
3161:
3155:
3154:
3151:
3148:
3145:
3142:
3139:
3136:
3130:
3129:
3126:
3123:
3120:
3117:
3114:
3111:
3105:
3104:
3101:
3098:
3095:
3092:
3089:
3086:
3080:
3079:
3076:
3073:
3070:
3067:
3064:
3061:
3055:
3054:
3051:
3048:
3045:
3042:
3039:
3036:
3030:
3029:
3026:
3023:
3020:
3017:
3014:
3011:
3005:
3004:
3001:
2998:
2995:
2992:
2989:
2986:
2980:
2979:
2976:
2973:
2970:
2967:
2964:
2961:
2955:
2954:
2951:
2948:
2945:
2942:
2939:
2936:
2930:
2929:
2926:
2923:
2920:
2917:
2914:
2911:
2905:
2904:
2901:
2898:
2895:
2892:
2889:
2886:
2880:
2879:
2876:
2873:
2870:
2867:
2864:
2861:
2855:
2854:
2851:
2848:
2845:
2842:
2839:
2836:
2830:
2829:
2826:
2823:
2820:
2817:
2814:
2811:
2805:
2804:
2801:
2798:
2795:
2792:
2789:
2786:
2780:
2779:
2776:
2773:
2770:
2767:
2764:
2761:
2755:
2754:
2751:
2748:
2745:
2742:
2739:
2736:
2730:
2729:
2726:
2723:
2720:
2717:
2714:
2711:
2705:
2704:
2701:
2698:
2695:
2692:
2689:
2686:
2680:
2679:
2676:
2673:
2670:
2667:
2666:41.2 (7.8–69)
2664:
2661:
2655:
2654:
2651:
2648:
2645:
2642:
2639:
2636:
2630:
2629:
2626:
2623:
2620:
2617:
2614:
2611:
2605:
2604:
2601:
2598:
2595:
2592:
2589:
2586:
2580:
2579:
2576:
2573:
2570:
2567:
2564:
2561:
2555:
2554:
2551:
2548:
2545:
2544:10 (0.98–339)
2542:
2539:
2536:
2530:
2529:
2526:
2523:
2520:
2519:3.33 (0.28–6)
2517:
2514:
2511:
2505:
2504:
2501:
2498:
2495:
2492:
2489:
2486:
2480:
2479:
2476:
2473:
2470:
2467:
2464:
2461:
2455:
2454:
2451:
2448:
2445:
2442:
2439:
2436:
2430:
2429:
2426:
2423:
2420:
2417:
2414:
2411:
2405:
2404:
2401:
2398:
2395:
2392:
2391:37 (20.4–223)
2389:
2386:
2380:
2379:
2376:
2373:
2370:
2367:
2364:
2361:
2355:
2354:
2351:
2348:
2345:
2342:
2339:
2336:
2330:
2329:
2326:
2323:
2320:
2317:
2314:
2311:
2305:
2304:
2301:
2298:
2295:
2292:
2289:
2286:
2280:
2279:
2276:
2273:
2270:
2267:
2264:
2261:
2255:
2254:
2251:
2248:
2245:
2242:
2239:
2236:
2230:
2229:
2226:
2223:
2220:
2217:
2214:
2211:
2205:
2204:
2201:
2198:
2195:
2192:
2189:
2186:
2180:
2179:
2176:
2173:
2170:
2167:
2164:
2161:
2155:
2154:
2151:
2148:
2145:
2142:
2139:
2136:
2130:
2129:
2126:
2123:
2120:
2117:
2114:
2111:
2105:
2104:
2101:
2098:
2095:
2092:
2089:
2086:
2080:
2079:
2076:
2073:
2070:
2067:
2064:
2061:
2055:
2054:
2051:
2048:
2045:
2042:
2041:13 (4.0–28.9)
2039:
2036:
2030:
2029:
2026:
2023:
2020:
2017:
2014:
2011:
2002:
2001:
1998:
1995:
1992:
1989:
1986:
1983:
1977:
1976:
1973:
1970:
1967:
1964:
1961:
1958:
1952:
1951:
1948:
1945:
1942:
1939:
1936:
1933:
1927:
1926:
1923:
1920:
1917:
1914:
1911:
1908:
1902:
1901:
1898:
1895:
1892:
1889:
1886:
1883:
1877:
1876:
1873:
1870:
1867:
1864:
1861:
1858:
1852:
1851:
1848:
1845:
1842:
1839:
1836:
1833:
1827:
1826:
1823:
1820:
1817:
1814:
1811:
1808:
1802:
1801:
1798:
1795:
1792:
1789:
1786:
1783:
1777:
1776:
1773:
1770:
1767:
1764:
1761:
1758:
1752:
1751:
1748:
1745:
1742:
1739:
1736:
1733:
1727:
1726:
1723:
1720:
1717:
1714:
1711:
1708:
1702:
1701:
1698:
1695:
1692:
1689:
1686:
1683:
1677:
1676:
1673:
1670:
1667:
1664:
1661:
1658:
1652:
1651:
1648:
1645:
1642:
1639:
1636:
1633:
1627:
1626:
1623:
1620:
1617:
1614:
1611:
1608:
1602:
1601:
1598:
1595:
1592:
1589:
1586:
1583:
1577:
1576:
1573:
1570:
1567:
1564:
1561:
1558:
1552:
1551:
1548:
1545:
1542:
1539:
1536:
1533:
1527:
1526:
1523:
1520:
1517:
1514:
1511:
1508:
1502:
1501:
1498:
1495:
1492:
1489:
1486:
1483:
1477:
1476:
1473:
1470:
1467:
1464:
1461:
1458:
1452:
1451:
1448:
1445:
1442:
1439:
1436:
1433:
1427:
1426:
1423:
1420:
1417:
1414:
1413:20.5 (7–80.1)
1411:
1408:
1402:
1401:
1398:
1395:
1392:
1389:
1386:
1383:
1377:
1376:
1373:
1370:
1367:
1364:
1361:
1358:
1352:
1351:
1348:
1345:
1342:
1341:6.5 (1.36–52)
1339:
1336:
1333:
1329:
1328:
1325:
1322:
1319:
1316:
1313:
1310:
1304:
1303:
1298:
1293:
1288:
1282:
1281:
1278:
1274:
1268:
1262:
1259:
1247:
1246:
1239:
1232:
1224:
1137:
1134:
1132:
1129:
1127:
1124:
1082:
1079:
1003:
1000:
955:Regardless of
915:ovariectomized
911:postmenopausal
878:
875:
869:of estradiol.
691:
690:
679:
678:
676:
675:
672:
670:
667:
659:
658:
657:
654:
653:
651:
650:
647:
639:
638:
637:
634:
633:
630:
624:
623:
621:
620:
612:
610:
602:
601:
595:
589:
588:
585:
579:
573:
568:
562:
561:
557:
556:
554:
553:
545:
543:
537:
536:
534:
533:
525:
523:
517:
516:
514:
513:
505:
503:
497:
496:
494:
493:
485:
483:
477:
476:
474:
473:
465:
463:
457:
456:
454:
453:
445:
443:
437:
436:
434:
433:
425:
423:
417:
416:
414:
413:
405:
403:
392:
391:
389:
388:
380:
378:
372:
371:
369:
368:
345:
337:
336:
335:
332:
331:
327:
326:
321:
315:
314:
303:
294:
293:
275:
269:
268:
250:
244:
243:
226:
220:
219:
213:
207:
206:
199:
198:
196:
195:
182:
180:
174:
173:
169:
168:
166:
165:
141:
139:
133:
132:
127:
121:
120:
93:
91:administration
85:
84:
81:
77:
76:
73:
67:
66:
62:
61:
53:
52:
26:
9:
6:
4:
3:
2:
14950:
14939:
14936:
14934:
14931:
14929:
14926:
14924:
14921:
14919:
14916:
14914:
14911:
14909:
14906:
14905:
14903:
14888:
14885:
14883:
14880:
14878:
14875:
14873:
14870:
14868:
14865:
14862:
14861:
14858:
14848:
14845:
14843:
14840:
14839:
14837:
14833:
14827:
14824:
14822:
14819:
14817:
14814:
14812:
14809:
14807:
14804:
14803:
14801:
14797:
14791:
14788:
14786:
14783:
14781:
14778:
14776:
14773:
14771:
14768:
14766:
14763:
14761:
14758:
14755:
14751:
14748:
14746:
14743:
14741:
14738:
14736:
14733:
14731:
14728:
14726:
14723:
14721:
14718:
14716:
14713:
14711:
14708:
14706:
14703:
14701:
14698:
14696:
14693:
14691:
14688:
14686:
14683:
14681:
14678:
14676:
14673:
14670:
14666:
14662:
14659:
14657:
14654:
14652:
14649:
14647:
14644:
14642:
14639:
14637:
14634:
14632:
14629:
14627:
14624:
14623:
14621:
14617:
14614:
14609:
14603:
14593:
14590:
14587:
14586:
14583:
14580:
14577:
14576:
14573:
14570:
14568:
14565:
14563:
14560:
14558:
14555:
14553:
14550:
14548:
14545:
14543:
14540:
14538:
14535:
14533:
14530:
14528:
14525:
14523:
14520:
14518:
14515:
14513:
14510:
14508:
14505:
14503:
14500:
14498:
14495:
14493:
14490:
14487:
14483:
14479:
14475:
14471:
14468:
14466:
14463:
14461:
14458:
14456:
14453:
14451:
14448:
14446:
14443:
14441:
14438:
14436:
14433:
14431:
14428:
14426:
14423:
14422:
14420:
14416:
14410:
14407:
14405:
14402:
14400:
14397:
14395:
14392:
14390:
14387:
14385:
14382:
14380:
14377:
14375:
14372:
14370:
14367:
14365:
14362:
14360:
14357:
14355:
14352:
14350:
14347:
14345:
14342:
14340:
14337:
14335:
14334:Pipendoxifene
14332:
14330:
14327:
14325:
14322:
14320:
14317:
14315:
14312:
14310:
14307:
14305:
14302:
14300:
14297:
14295:
14292:
14290:
14287:
14285:
14282:
14280:
14277:
14275:
14272:
14270:
14267:
14265:
14262:
14260:
14257:
14255:
14252:
14250:
14247:
14245:
14242:
14240:
14237:
14235:
14232:
14230:
14227:
14225:
14222:
14220:
14217:
14215:
14212:
14210:
14207:
14205:
14202:
14200:
14197:
14195:
14192:
14190:
14187:
14185:
14182:
14180:
14177:
14175:
14172:
14170:
14169:Clomifenoxide
14167:
14165:
14162:
14160:
14157:
14155:
14152:
14150:
14147:
14145:
14144:Brilanestrant
14142:
14140:
14137:
14135:
14132:
14130:
14127:
14125:
14122:
14120:
14117:
14115:
14112:
14110:
14107:
14105:
14102:
14100:
14097:
14095:
14092:
14090:
14087:
14086:
14084:
14078:
14069:
14062:
14058:
14054:
14051:
14047:
14043:
14039:
14035:
14031:
14027:
14023:
14019:
14015:
14011:
14007:
14004:
14001:
13997:
13993:
13990:
13987:
13983:
13980:-like (e.g.,
13979:
13976:
13973:
13969:
13965:
13961:
13957:
13953:
13949:
13946:
13943:
13939:
13935:
13931:
13928:
13925:
13924:guggulsterone
13921:
13917:
13913:
13909:
13908:Phytosteroids
13906:
13903:
13899:
13895:
13891:
13887:
13883:
13879:
13875:
13871:
13867:
13864:
13861:
13857:
13854:
13851:
13849:
13843:
13842:enterolactone
13839:
13835:
13832:
13830:
13827:
13824:
13820:
13816:
13812:
13808:
13804:
13800:
13796:
13792:
13788:
13784:
13780:
13776:
13772:
13768:
13764:
13760:
13756:
13752:
13748:
13744:
13740:
13736:
13732:
13728:
13724:
13720:
13716:
13712:
13708:
13704:
13700:
13696:
13693:
13690:
13686:
13682:
13679:
13676:
13675:wedelolactone
13672:
13668:
13664:
13660:
13657:
13654:
13653:photoanethole
13650:
13646:
13642:
13638:
13634:
13631:
13628:
13627:
13624:
13621:
13619:
13616:
13614:
13611:
13609:
13606:
13603:
13602:
13599:
13596:
13594:
13591:
13589:
13586:
13584:
13581:
13579:
13576:
13574:
13571:
13569:
13566:
13564:
13561:
13559:
13556:
13554:
13551:
13549:
13546:
13544:
13541:
13539:
13536:
13534:
13531:
13529:
13526:
13524:
13521:
13519:
13516:
13514:
13511:
13509:
13508:Pentafluranol
13506:
13504:
13501:
13499:
13496:
13494:
13491:
13489:
13486:
13484:
13481:
13479:
13477:
13473:
13471:
13469:
13465:
13463:
13460:
13458:
13455:
13451:
13448:
13447:
13446:
13443:
13441:
13438:
13436:
13433:
13431:
13428:
13426:
13423:
13421:
13418:
13416:
13413:
13411:
13408:
13406:
13403:
13401:
13398:
13396:
13393:
13391:
13388:
13386:
13383:
13381:
13378:
13376:
13373:
13369:
13366:
13365:
13364:
13361:
13357:
13354:
13353:
13352:
13349:
13347:
13344:
13342:
13339:
13337:
13334:
13332:
13329:
13327:
13324:
13322:
13319:
13317:
13314:
13312:
13309:
13307:
13304:
13302:
13299:
13297:
13294:
13292:
13289:
13287:
13284:
13282:
13279:
13277:
13274:
13272:
13269:
13268:Nonsteroidal:
13266:
13265:
13262:
13259:
13257:
13254:
13252:
13249:
13247:
13244:
13242:
13239:
13237:
13234:
13232:
13229:
13227:
13224:
13222:
13219:
13217:
13214:
13212:
13209:
13207:
13204:
13202:
13199:
13197:
13194:
13192:
13189:
13187:
13184:
13182:
13179:
13177:
13174:
13172:
13169:
13167:
13164:
13162:
13159:
13157:
13154:
13152:
13149:
13147:
13144:
13142:
13139:
13135:
13132:
13130:
13127:
13126:
13125:
13122:
13118:
13117:Ethandrostate
13115:
13114:
13113:
13110:
13108:
13105:
13101:
13098:
13096:
13093:
13091:
13088:
13087:
13086:
13083:
13081:
13078:
13076:
13073:
13071:
13068:
13064:
13061:
13059:
13056:
13055:
13054:
13051:
13049:
13046:
13044:
13041:
13039:
13036:
13034:
13031:
13027:
13024:
13022:
13019:
13017:
13014:
13013:
13012:
13009:
13007:
13004:
13002:
12999:
12997:
12994:
12992:
12989:
12987:
12984:
12982:
12979:
12977:
12974:
12972:
12970:
12966:
12964:
12961:
12959:
12956:
12954:
12951:
12949:
12946:
12944:
12941:
12939:
12936:
12932:
12929:
12928:
12927:
12926:Cloxestradiol
12924:
12922:
12919:
12917:
12914:
12912:
12909:
12907:
12904:
12902:
12899:
12896:
12892:
12888:
12884:
12880:
12876:
12872:
12869:
12867:
12864:
12862:
12859:
12857:
12854:
12852:
12849:
12847:
12844:
12842:
12839:
12837:
12834:
12832:
12829:
12827:
12824:
12822:
12819:
12817:
12814:
12812:
12809:
12806:
12802:
12801:17α-Estradiol
12799:
12797:
12794:
12792:
12789:
12787:
12784:
12782:
12779:
12777:
12774:
12772:
12769:
12767:
12764:
12762:
12759:
12757:
12754:
12752:
12749:
12747:
12744:
12742:
12739:
12737:
12734:
12732:
12729:
12727:
12724:
12722:
12719:
12717:
12714:
12712:
12709:
12707:
12704:
12702:
12699:
12697:
12694:
12692:
12689:
12687:
12684:
12682:
12679:
12677:
12674:
12672:
12669:
12667:
12664:
12662:
12659:
12657:
12654:
12652:
12649:
12647:
12644:
12642:
12639:
12637:
12634:
12632:
12629:
12627:
12624:
12622:
12619:
12617:
12614:
12611:
12610:
12608:
12604:
12601:
12596:
12590:
12586:
12583:
12576:
12571:
12569:
12564:
12562:
12557:
12556:
12553:
12541:
12538:
12536:
12533:
12531:
12528:
12526:
12523:
12520:
12519:
12512:
12510:
12507:
12506:
12504:
12501:
12498:
12495:
12493:
12490:
12489:
12485:
12475:
12472:
12470:
12467:
12464:
12463:
12460:
12457:
12455:
12452:
12449:
12448:
12446:
12442:
12435:
12431:
12427:
12423:
12419:
12415:
12411:
12408:
12405:
12401:
12397:
12391:
12388:
12384:
12380:
12374:
12371:
12367:
12363:
12359:
12355:
12351:
12347:
12343:
12340:
12333:
12330:
12326:
12322:
12318:
12314:
12310:
12306:
12303:
12302:
12300:
12298:
12294:
12288:
12285:
12283:
12280:
12278:
12275:
12272:
12271:
12268:
12265:
12263:
12260:
12257:
12256:
12253:
12250:
12248:
12245:
12242:
12241:
12239:
12237:
12233:
12227:
12224:
12221:
12220:
12217:
12214:
12212:
12209:
12206:
12205:
12202:
12199:
12197:
12194:
12192:
12189:
12187:
12184:
12182:
12179:
12177:
12174:
12172:
12169:
12167:
12164:
12162:
12159:
12157:
12154:
12152:
12149:
12147:
12144:
12142:
12139:
12137:
12134:
12132:
12129:
12128:
12126:
12120:
12111:
12100:
12094:
12091:
12089:
12088:Antiestrogens
12085:
12071:
12062:
12056:
12055:Gonadotropins
12053:
12050:
12046:
12045:(gonadorelin)
12039:
12033:
12030:
12026:
12025:Antiandrogens
12023:
12022:
12020:
12018:
12014:
12008:
12005:
12003:
12000:
11998:
11995:
11993:
11990:
11988:
11985:
11981:
11978:
11977:
11976:
11973:
11971:
11968:
11964:
11961:
11960:
11959:
11956:
11954:
11951:
11947:
11944:
11942:
11939:
11937:
11934:
11933:
11932:
11929:
11927:
11924:
11920:
11917:
11916:
11915:
11912:
11910:
11907:
11905:
11902:
11900:
11897:
11896:Nonsteroidal:
11894:
11893:
11890:
11887:
11885:
11882:
11880:
11877:
11873:
11870:
11868:
11865:
11864:
11863:
11860:
11858:
11855:
11853:
11850:
11848:
11845:
11843:
11840:
11838:
11835:
11831:
11828:
11827:
11826:
11823:
11819:
11816:
11814:
11811:
11810:
11809:
11806:
11804:
11801:
11799:
11796:
11793:
11789:
11785:
11782:
11780:
11777:
11775:
11772:
11769:
11765:
11761:
11757:
11753:
11749:
11745:
11741:
11737:
11733:
11730:
11728:
11725:
11723:
11720:
11718:
11715:
11713:
11710:
11708:
11705:
11703:
11700:
11698:
11695:
11693:
11690:
11688:
11685:
11682:
11678:
11674:
11670:
11666:
11662:
11659:
11655:
11651:
11647:
11643:
11639:
11635:
11631:
11629:
11626:
11623:
11622:
11620:
11614:
11608:
11605:
11603:
11599:
11595:
11594:antiestrogens
11591:
11584:
11579:
11577:
11572:
11570:
11565:
11564:
11561:
11552:
11548:
11544:
11540:
11536:
11532:
11528:
11524:
11517:
11512:
11508:
11502:
11498:
11497:
11491:
11490:
11476:
11472:
11468:
11464:
11460:
11456:
11449:
11441:
11437:
11432:
11427:
11423:
11419:
11415:
11411:
11407:
11400:
11392:
11388:
11387:"Estropipate"
11382:
11374:
11368:
11364:
11363:
11355:
11347:
11341:
11337:
11336:
11328:
11320:
11314:
11310:
11309:
11301:
11294:
11289:
11285:
11281:
11277:
11273:
11269:
11262:
11254:
11250:
11246:
11242:
11238:
11234:
11227:
11219:
11213:
11209:
11208:
11200:
11192:
11188:
11183:
11178:
11174:
11170:
11166:
11159:
11157:
11155:
11146:
11142:
11138:
11134:
11130:
11126:
11119:
11117:
11108:
11104:
11100:
11096:
11092:
11088:
11081:
11074:
11070:
11064:
11060:
11059:
11051:
11043:
11037:
11033:
11032:
11024:
11022:
11013:
11007:
11003:
10999:
10992:
10984:
10980:
10976:
10972:
10968:
10964:
10957:
10955:
10953:
10944:
10940:
10935:
10930:
10926:
10922:
10918:
10911:
10904:
10899:
10893:
10889:
10888:
10880:
10872:
10868:
10863:
10858:
10854:
10850:
10846:
10839:
10831:
10827:
10823:
10819:
10815:
10811:
10804:
10796:
10792:
10787:
10782:
10778:
10774:
10770:
10766:
10762:
10755:
10747:
10741:
10737:
10733:
10729:
10722:
10720:
10718:
10709:
10705:
10701:
10697:
10693:
10689:
10685:
10681:
10674:
10666:
10662:
10657:
10652:
10648:
10644:
10640:
10633:
10626:
10621:
10617:
10613:
10609:
10605:
10601:
10594:
10587:
10579:
10575:
10570:
10565:
10561:
10557:
10553:
10546:
10539:
10535:
10531:
10526:
10521:
10517:
10513:
10509:
10505:
10501:
10494:
10486:
10482:
10478:
10474:
10471:(3): 536–41.
10470:
10466:
10458:
10450:
10446:
10442:
10438:
10431:
10423:
10419:
10415:
10411:
10407:
10403:
10399:
10395:
10392:(1): 506–24.
10391:
10387:
10380:
10372:
10368:
10363:
10358:
10354:
10350:
10347:(3): 505–40.
10346:
10342:
10338:
10331:
10323:
10319:
10315:
10311:
10307:
10303:
10296:
10294:
10292:
10290:
10281:
10277:
10273:
10269:
10265:
10261:
10253:
10251:
10249:
10247:
10245:
10236:
10232:
10228:
10224:
10220:
10216:
10212:
10208:
10200:
10198:
10196:
10194:
10192:
10183:
10179:
10175:
10171:
10167:
10163:
10159:
10155:
10148:
10146:
10137:
10133:
10128:
10123:
10119:
10115:
10114:J. Biol. Chem
10111:
10104:
10102:
10093:
10087:
10083:
10082:
10074:
10072:
10063:
10059:
10055:
10051:
10048:(3): 171–97.
10047:
10043:
10036:
10028:
10024:
10020:
10016:
10013:(2): 152–75.
10012:
10008:
10007:Toxicol. Lett
10001:
9993:
9989:
9985:
9981:
9977:
9973:
9969:
9965:
9961:
9954:
9946:
9942:
9937:
9932:
9928:
9924:
9921:(7): 734–42.
9920:
9916:
9912:
9905:
9897:
9891:
9887:
9883:
9876:
9874:
9865:
9861:
9857:
9853:
9849:
9845:
9837:
9835:
9833:
9824:
9820:
9816:
9812:
9808:
9804:
9797:
9795:
9793:
9791:
9789:
9787:
9785:
9776:
9772:
9768:
9764:
9760:
9756:
9749:
9747:
9745:
9743:
9741:
9739:
9737:
9728:
9724:
9720:
9716:
9712:
9708:
9704:
9700:
9693:
9691:
9689:
9687:
9685:
9683:
9681:
9672:
9668:
9664:
9660:
9656:
9652:
9645:
9637:
9633:
9629:
9625:
9621:
9617:
9610:
9602:
9598:
9594:
9590:
9586:
9582:
9575:
9567:
9563:
9558:
9553:
9549:
9545:
9541:
9534:
9532:
9530:
9521:
9517:
9513:
9509:
9505:
9501:
9494:
9492:
9490:
9488:
9480:
9476:
9470:
9466:
9465:
9457:
9449:
9445:
9440:
9435:
9430:
9425:
9421:
9417:
9416:BMC Emerg Med
9413:
9406:
9399:
9395:
9391:
9387:
9383:
9379:
9375:
9371:
9367:
9360:
9353:
9349:
9343:
9339:
9332:
9324:
9318:
9314:
9313:
9312:The Menopause
9305:
9297:
9291:
9287:
9283:
9276:
9268:
9262:
9258:
9254:
9247:
9239:
9233:
9225:
9224:
9216:
9208:
9202:
9198:
9194:
9187:
9185:
9183:
9174:
9168:
9164:
9160:
9153:
9151:
9144:
9139:
9137:
9135:
9126:
9120:
9116:
9112:
9105:
9097:
9093:
9089:
9085:
9081:
9077:
9070:
9068:
9066:
9064:
9056:
9051:
9045:
9041:
9040:
9032:
9024:
9018:
9014:
9010:
9003:
8995:
8989:
8985:
8984:
8975:
8967:
8961:
8950:
8944:
8942:
8940:
8931:
8925:
8921:
8917:
8913:
8909:
8902:
8900:
8898:
8881:
8877:
8871:
8869:
8867:
8865:
8863:
8861:
8859:
8850:
8844:
8840:
8839:
8831:
8829:
8820:
8816:
8811:
8806:
8802:
8798:
8794:
8787:
8785:
8783:
8781:
8779:
8771:
8766:
8760:
8756:
8755:
8747:
8745:
8743:
8741:
8732:
8726:
8722:
8718:
8714:
8707:
8705:
8703:
8694:
8688:
8684:
8683:The Menopause
8680:
8673:
8671:
8669:
8667:
8658:
8652:
8648:
8647:
8639:
8637:
8635:
8633:
8624:
8618:
8614:
8613:
8606:
8604:
8602:
8600:
8598:
8596:
8594:
8592:
8590:
8588:
8586:
8577:
8571:
8567:
8566:
8558:
8556:
8554:
8552:
8550:
8548:
8546:
8544:
8535:
8529:
8525:
8521:
8514:
8512:
8503:
8497:
8493:
8492:
8484:
8482:
8473:
8469:
8465:
8461:
8457:
8453:
8449:
8445:
8438:
8431:
8429:
8427:
8425:
8423:
8421:
8419:
8417:
8415:
8413:
8411:
8409:
8407:
8405:
8403:
8401:
8399:
8397:
8395:
8393:
8391:
8389:
8387:
8385:
8383:
8381:
8379:
8377:
8375:
8373:
8371:
8369:
8367:
8365:
8363:
8361:
8359:
8357:
8355:
8353:
8344:
8338:
8334:
8330:
8323:
8321:
8319:
8310:
8304:
8300:
8296:
8292:
8285:
8283:
8281:
8279:
8270:
8264:
8260:
8256:
8252:
8245:
8243:
8241:
8239:
8237:
8228:
8222:
8218:
8217:
8209:
8207:
8205:
8203:
8201:
8199:
8194:
8184:
8181:
8179:
8176:
8174:
8171:
8170:
8164:
8162:
8158:
8154:
8144:
8142:
8138:
8134:
8130:
8126:
8122:
8118:
8114:
8108:
8104:
8100:
8090:
8086:
8084:
8073:
8071:
8067:
8060:
8054:
8047:
8038:
8029:
8020:
8011:
8002:
7996:
7992:
7988:
7982:Generic names
7974:
7972:
7968:
7965:. Estrone in
7964:
7963:suppositories
7961:
7957:
7954:
7950:
7946:
7942:
7938:
7934:
7930:
7926:
7922:
7918:
7914:
7910:
7906:
7902:
7898:
7894:
7890:
7886:
7882:
7878:
7874:
7870:
7866:
7862:
7858:
7854:
7850:
7846:
7842:
7838:
7834:
7830:
7826:
7820:
7810:
7808:
7804:
7800:
7796:
7792:
7788:
7784:
7780:
7776:
7772:
7769:A variety of
7767:
7765:
7764:
7758:
7757:
7755:
7749:
7745:
7742:
7738:
7734:
7730:
7727:
7724:
7711:
7707:
7689:
7681:
7673:
7648:
7643:
7641:
7636:
7634:
7629:
7628:
7623:
7622:
7618:
7614:
7604:
7602:
7598:
7594:
7590:
7586:
7582:
7578:
7574:
7564:
7562:
7557:
7555:
7551:
7547:
7543:
7539:
7534:
7530:
7525:
7523:
7519:
7515:
7511:
7507:
7503:
7499:
7495:
7491:
7487:
7483:
7479:
7475:
7472:enzymes into
7471:
7467:
7463:
7459:
7455:
7451:
7447:
7443:
7428:
7424:
7420:
7416:
7412:
7408:
7404:
7400:
7396:
7392:
7388:
7385:
7381:
7377:
7373:
7369:
7348:
7336:
7333:
7328:
7319:
7310:
7303:
7300:
7295:
7286:
7279:
7276:
7271:
7265:
7256:
7247:
7238:
7231:
7228:
7223:
7222:16-Epiestriol
7216:
7209:
7208:17-Epiestriol
7204:
7199:
7192:
7185:
7180:
7175:
7168:
7167:
7159:
7154:
7149:
7142:
7135:
7118:
7114:
7108:
7103:
7101:
7096:
7094:
7089:
7088:
7083:
7082:
7073:
7071:
7067:
7063:
7059:
7049:
7045:
7043:
7039:
7035:
7031:
7027:
7023:
7020:, 50 μg
7019:
7015:
7011:
7008:
6987:
6975:
6971:
6967:
6966:6,7-estradiol
6963:
6959:
6955:
6951:
6950:radioactivity
6947:
6941:
6936:
6932:
6928:
6924:
6920:
6919:vaginal smear
6913:
6908:
6904:
6901:
6897:
6893:
6889:
6885:
6884:cornification
6882:
6875:
6870:
6869:
6860:
6855:
6853:
6848:
6846:
6841:
6840:
6828:See template.
6827:
6823:
6819:
6815:
6811:
6807:
6804:
6800:
6796:
6792:
6791:particle size
6789:
6785:
6781:
6776:
6770:
6766:
6763:
6760:
6757:
6755:
6752:
6751:
6747:
6744:
6741:
6738:
6736:
6733:
6732:
6728:
6725:
6722:
6719:
6718:
6714:
6711:
6708:
6705:
6701:
6695:
6692:
6689:
6686:
6684:
6681:
6680:
6674:
6671:
6668:
6665:
6663:
6660:
6659:
6655:
6652:
6649:
6646:
6644:
6641:
6640:
6637:10 ≈ 20–30 d
6636:
6633:
6630:
6627:
6625:
6622:
6621:
6617:
6614:
6611:
6608:
6607:
6603:
6600:
6597:
6594:
6592:
6588:
6584:
6581:
6578:
6575:
6573:
6570:
6569:
6563:
6560:
6557:
6554:
6552:
6549:
6548:
6544:
6541:
6538:
6535:
6533:
6530:
6529:
6526:10 ≈ 14–21 d
6525:
6522:
6519:
6516:
6515:
6512:10 ≈ 16–21 d
6511:
6508:
6505:
6502:
6501:
6497:
6494:
6491:
6488:
6486:
6482:
6478:
6475:
6472:
6469:
6468:
6464:
6461:
6458:
6455:
6454:
6450:
6447:
6444:
6441:
6440:
6436:
6433:
6430:
6427:
6425:
6421:
6415:
6410:
6409:
6395:
6386:
6381:
6379:
6374:
6372:
6367:
6366:
6356:See template.
6355:
6351:
6350:gonadotropins
6347:
6320:
6307:
6294:
6284:
6280:
6279:proliferation
6272:
6265:
6261:
6252:
6248:
6245:
6242:
6239:
6236:
6233:
6230:
6227:
6224:
6221:
6219:
6216:
6215:
6211:
6208:
6205:
6202:
6199:
6196:
6193:
6190:
6187:
6184:
6182:
6179:
6178:
6174:
6171:
6168:
6165:
6162:
6159:
6156:
6153:
6150:
6147:
6145:
6142:
6141:
6137:
6134:
6131:
6128:
6125:
6122:
6119:
6116:
6113:
6110:
6108:
6105:
6104:
6100:
6097:
6094:
6091:
6088:
6085:
6082:
6079:
6076:
6073:
6071:
6068:
6067:
6063:
6060:
6057:
6054:
6051:
6048:
6045:
6042:
6039:
6036:
6034:
6031:
6030:
6026:
6023:
6020:
6017:
6014:
6011:
6008:
6005:
6002:
5999:
5996:
5995:
5991:
5988:
5985:
5982:
5979:
5976:
5973:
5970:
5967:
5964:
5962:
5959:
5958:
5947:
5937:
5927:
5917:
5908:
5898:
5888:
5878:
5868:
5858:
5850:
5849:
5842:
5837:
5835:
5830:
5828:
5823:
5822:
5818:
5816:
5813:
5809:
5808:
5804:
5800:
5796:
5792:
5788:
5784:
5780:
5776:
5772:
5768:
5764:
5760:
5756:
5752:
5748:
5747:premenopausal
5744:
5743:physiological
5740:
5736:
5731:
5729:
5725:
5722:, as well as
5721:
5717:
5713:
5709:
5705:
5701:
5697:
5693:
5689:
5685:
5681:
5677:
5673:
5669:
5665:
5661:
5657:
5653:
5649:
5645:
5641:
5637:
5633:
5629:
5625:
5621:
5617:
5613:
5609:
5605:
5601:
5597:
5593:
5589:
5585:
5570:
5566:
5562:
5558:
5554:
5546:
5545:osmotic pumps
5543:
5539:
5535:
5532:
5528:
5524:
5513:
5509:
5505:
5502:
5499:
5496:
5493:
5491:
5488:
5487:
5483:
5480:
5477:
5474:
5471:
5469:
5466:
5465:
5461:
5458:
5455:
5452:
5449:
5447:
5444:
5443:
5439:
5436:
5433:
5430:
5427:
5425:
5422:
5421:
5417:
5414:
5411:
5408:
5405:
5403:
5400:
5399:
5395:
5392:
5389:
5386:
5383:
5381:
5378:
5377:
5373:
5370:
5367:
5364:
5361:
5359:
5356:
5355:
5351:
5348:
5345:
5342:
5339:
5337:
5334:
5333:
5329:
5326:
5323:
5320:
5317:
5315:
5312:
5311:
5307:
5304:
5301:
5298:
5295:
5293:
5290:
5289:
5285:
5282:
5279:
5276:
5273:
5271:
5268:
5267:
5263:
5260:
5257:
5254:
5251:
5249:
5246:
5245:
5241:
5238:
5235:
5232:
5229:
5227:
5226:17α-Estradiol
5224:
5223:
5219:
5216:
5213:
5210:
5207:
5205:
5204:Estetrol (E4)
5202:
5201:
5197:
5194:
5191:
5188:
5185:
5183:
5180:
5179:
5175:
5172:
5169:
5166:
5163:
5160:
5159:
5155:
5152:
5149:
5146:
5143:
5141:
5138:
5137:
5133:
5130:
5127:
5124:
5121:
5118:
5117:
5110:
5102:
5097:
5091:
5086:
5084:
5081:
5078:
5075:
5069:
5061:
5056:
5054:
5051:
5050:
5043:
5038:
5036:
5031:
5029:
5024:
5023:
5014:
5007:
5001:
4994:
4988:
4981:
4975:
4968:
4962:
4961:dexamethasone
4955:
4949:
4942:
4936:
4929:
4923:
4919:
4915:
4911:
4907:
4904:
4901:
4898:
4895:
4892:
4889:
4887:
4884:
4883:
4879:
4876:
4873:
4870:
4867:
4864:
4861:
4859:
4856:
4855:
4851:
4848:
4845:
4842:
4839:
4836:
4833:
4831:
4828:
4827:
4823:
4820:
4817:
4814:
4811:
4808:
4805:
4803:
4800:
4799:
4795:
4792:
4789:
4786:
4783:
4780:
4777:
4775:
4772:
4771:
4767:
4764:
4761:
4758:
4755:
4752:
4749:
4747:
4744:
4743:
4739:
4736:
4733:
4730:
4727:
4724:
4721:
4719:
4716:
4715:
4711:
4708:
4705:
4702:
4699:
4696:
4693:
4691:
4688:
4687:
4683:
4680:
4677:
4674:
4671:
4668:
4665:
4663:
4660:
4659:
4655:
4652:
4649:
4646:
4643:
4640:
4637:
4635:
4632:
4631:
4627:
4624:
4621:
4618:
4615:
4612:
4609:
4606:
4605:
4601:
4598:
4595:
4592:
4589:
4586:
4583:
4581:
4578:
4577:
4573:
4570:
4567:
4564:
4561:
4558:
4555:
4553:
4550:
4549:
4545:
4542:
4539:
4536:
4533:
4530:
4527:
4525:
4522:
4521:
4515:
4510:
4505:
4500:
4495:
4490:
4485:
4480:
4475:
4470:
4465:
4460:
4455:
4450:
4449:
4445:
4440:
4436:
4429:
4424:
4422:
4417:
4415:
4410:
4409:
4400:
4396:
4392:
4388:
4385:systems with
4384:
4383:
4377:
4373:
4369:
4365:
4362:
4359:
4356:
4353:
4350:
4348:
4345:
4344:
4340:
4337:
4334:
4331:
4328:
4325:
4323:
4320:
4319:
4315:
4312:
4309:
4307:0.027–<0.1
4306:
4304:0.069–<0.1
4303:
4300:
4298:
4295:
4294:
4290:
4287:
4284:
4281:
4278:
4275:
4273:
4270:
4269:
4265:
4262:
4259:
4256:
4253:
4250:
4248:
4247:Norethynodrel
4245:
4244:
4240:
4237:
4234:
4231:
4228:
4225:
4223:
4220:
4219:
4215:
4212:
4209:
4206:
4204:<0.001–0.6
4203:
4200:
4198:
4195:
4194:
4190:
4187:
4184:
4181:
4178:
4175:
4173:
4170:
4169:
4165:
4162:
4159:
4156:
4153:
4150:
4148:
4145:
4144:
4140:
4137:
4134:
4131:
4128:
4125:
4123:
4120:
4119:
4115:
4112:
4109:
4106:
4103:
4100:
4098:
4095:
4094:
4090:
4087:
4084:
4081:
4078:
4075:
4073:
4070:
4069:
4065:
4062:
4059:
4056:
4053:
4050:
4048:
4045:
4044:
4040:
4037:
4034:
4031:
4028:
4025:
4023:
4020:
4019:
4015:
4012:
4009:
4006:
4003:
4000:
3998:
3995:
3994:
3990:
3987:
3984:
3981:
3978:
3975:
3973:
3970:
3969:
3965:
3962:
3959:
3956:
3953:
3950:
3948:
3945:
3944:
3940:
3937:
3934:
3931:
3928:
3925:
3923:
3920:
3919:
3915:
3912:
3909:
3906:
3903:
3900:
3898:
3895:
3894:
3890:
3887:
3884:
3881:
3878:
3875:
3873:
3870:
3869:
3865:
3862:
3859:
3856:
3853:
3850:
3848:
3845:
3844:
3841:Xenoestrogen
3840:
3837:
3834:
3831:
3828:
3825:
3821:
3819:
3816:
3815:
3812:Xenoestrogen
3811:
3808:
3805:
3802:
3799:
3796:
3793:
3791:
3788:
3787:
3784:Xenoestrogen
3783:
3780:
3777:
3774:
3771:
3768:
3766:
3764:
3760:
3759:
3756:Xenoestrogen
3755:
3752:
3749:
3746:
3743:
3740:
3738:
3736:
3732:
3731:
3728:Xenoestrogen
3727:
3724:
3721:
3718:
3715:
3712:
3710:
3707:
3706:
3703:Xenoestrogen
3702:
3699:
3696:
3693:
3690:
3687:
3685:
3682:
3681:
3678:Xenoestrogen
3677:
3674:
3671:
3668:
3665:
3662:
3660:
3657:
3656:
3653:Xenoestrogen
3652:
3649:
3646:
3643:
3640:
3637:
3635:
3632:
3631:
3628:Xenoestrogen
3627:
3624:
3621:
3618:
3615:
3612:
3610:
3607:
3606:
3603:Xenoestrogen
3602:
3599:
3596:
3593:
3591:16 (13–17.8)
3590:
3587:
3585:
3582:
3581:
3578:Xenoestrogen
3577:
3574:
3571:
3568:
3565:
3562:
3560:
3557:
3556:
3553:Xenoestrogen
3552:
3549:
3546:
3543:
3540:
3537:
3535:
3532:
3531:
3528:Xenoestrogen
3527:
3524:
3521:
3518:
3516:48 (13–52.5)
3515:
3512:
3510:
3507:
3506:
3503:Xenoestrogen
3502:
3499:
3496:
3493:
3490:
3487:
3485:
3482:
3481:
3478:Xenoestrogen
3477:
3474:
3471:
3468:
3465:
3462:
3460:
3457:
3456:
3453:Xenoestrogen
3452:
3449:
3446:
3443:
3440:
3437:
3435:
3432:
3431:
3428:Xenoestrogen
3427:
3424:
3421:
3418:
3415:
3412:
3410:
3407:
3406:
3403:Xenoestrogen
3402:
3399:
3396:
3393:
3390:
3387:
3385:
3382:
3381:
3378:Xenoestrogen
3377:
3374:
3371:
3368:
3365:
3362:
3360:
3357:
3356:
3353:Xenoestrogen
3352:
3349:
3346:
3343:
3340:
3337:
3335:
3332:
3331:
3328:Xenoestrogen
3327:
3324:
3321:
3318:
3315:
3312:
3310:
3307:
3306:
3303:Xenoestrogen
3302:
3299:
3296:
3293:
3290:
3287:
3285:
3282:
3281:
3278:Xenoestrogen
3277:
3274:
3271:
3268:
3265:
3262:
3260:
3257:
3256:
3253:Xenoestrogen
3252:
3249:
3246:
3243:
3240:
3237:
3235:
3232:
3231:
3228:Xenoestrogen
3227:
3224:
3221:
3218:
3215:
3212:
3210:
3207:
3206:
3203:Xenoestrogen
3202:
3199:
3196:
3193:
3190:
3187:
3185:
3182:
3181:
3178:Xenoestrogen
3177:
3174:
3171:
3168:
3165:
3162:
3160:
3157:
3156:
3152:
3149:
3146:
3143:
3140:
3137:
3135:
3132:
3131:
3127:
3124:
3121:
3118:
3115:
3112:
3110:
3107:
3106:
3102:
3099:
3096:
3093:
3090:
3087:
3085:
3082:
3081:
3077:
3074:
3071:
3068:
3065:
3062:
3060:
3057:
3056:
3052:
3049:
3046:
3043:
3040:
3037:
3035:
3032:
3031:
3027:
3024:
3021:
3018:
3015:
3012:
3010:
3007:
3006:
3002:
2999:
2996:
2993:
2990:
2987:
2985:
2982:
2981:
2977:
2974:
2971:
2968:
2965:
2962:
2960:
2957:
2956:
2952:
2949:
2946:
2943:
2940:
2937:
2935:
2932:
2931:
2927:
2924:
2921:
2918:
2915:
2912:
2910:
2907:
2906:
2903:Antiestrogen
2902:
2899:
2896:
2893:
2890:
2887:
2885:
2882:
2881:
2878:Antiestrogen
2877:
2874:
2871:
2868:
2865:
2862:
2860:
2857:
2856:
2852:
2849:
2846:
2843:
2840:
2837:
2835:
2832:
2831:
2827:
2824:
2821:
2818:
2815:
2812:
2810:
2807:
2806:
2802:
2799:
2796:
2793:
2790:
2787:
2785:
2782:
2781:
2777:
2774:
2771:
2768:
2765:
2762:
2760:
2757:
2756:
2752:
2749:
2746:
2743:
2740:
2737:
2735:
2732:
2731:
2727:
2724:
2721:
2718:
2715:
2712:
2710:
2707:
2706:
2702:
2699:
2696:
2693:
2690:
2687:
2685:
2682:
2681:
2677:
2674:
2671:
2668:
2665:
2662:
2660:
2657:
2656:
2652:
2649:
2646:
2643:
2640:
2637:
2635:
2632:
2631:
2627:
2624:
2621:
2618:
2615:
2612:
2610:
2607:
2606:
2602:
2599:
2596:
2593:
2590:
2587:
2585:
2582:
2581:
2577:
2574:
2571:
2568:
2565:
2562:
2560:
2557:
2556:
2552:
2549:
2546:
2543:
2540:
2537:
2535:
2532:
2531:
2527:
2524:
2521:
2518:
2515:
2512:
2510:
2507:
2506:
2502:
2499:
2496:
2493:
2490:
2487:
2485:
2482:
2481:
2477:
2474:
2471:
2468:
2465:
2462:
2460:
2457:
2456:
2452:
2449:
2446:
2443:
2440:
2437:
2435:
2432:
2431:
2427:
2424:
2421:
2418:
2415:
2412:
2410:
2407:
2406:
2402:
2399:
2396:
2393:
2390:
2387:
2385:
2382:
2381:
2377:
2374:
2371:
2368:
2365:
2362:
2360:
2357:
2356:
2352:
2349:
2346:
2343:
2340:
2337:
2335:
2332:
2331:
2327:
2324:
2321:
2318:
2315:
2312:
2310:
2307:
2306:
2302:
2299:
2296:
2293:
2290:
2287:
2285:
2282:
2281:
2277:
2274:
2271:
2268:
2265:
2262:
2260:
2257:
2256:
2252:
2249:
2246:
2243:
2240:
2237:
2235:
2232:
2231:
2227:
2224:
2221:
2218:
2215:
2212:
2210:
2207:
2206:
2202:
2199:
2196:
2193:
2190:
2187:
2185:
2182:
2181:
2177:
2174:
2171:
2168:
2165:
2162:
2160:
2157:
2156:
2152:
2149:
2146:
2143:
2140:
2137:
2135:
2132:
2131:
2127:
2124:
2121:
2118:
2116:18.6 (18–41)
2115:
2112:
2110:
2107:
2106:
2102:
2099:
2096:
2093:
2090:
2087:
2085:
2082:
2081:
2077:
2074:
2071:
2068:
2065:
2062:
2060:
2057:
2056:
2052:
2049:
2046:
2043:
2040:
2037:
2035:
2032:
2031:
2027:
2024:
2021:
2018:
2015:
2012:
2010:
2008:
2004:
2003:
1999:
1996:
1993:
1990:
1987:
1984:
1982:
1979:
1978:
1974:
1971:
1968:
1965:
1962:
1959:
1957:
1954:
1953:
1949:
1946:
1943:
1940:
1937:
1934:
1932:
1929:
1928:
1924:
1921:
1918:
1915:
1912:
1909:
1907:
1904:
1903:
1899:
1896:
1893:
1890:
1887:
1884:
1882:
1879:
1878:
1874:
1871:
1868:
1865:
1862:
1859:
1857:
1854:
1853:
1849:
1846:
1843:
1840:
1837:
1834:
1832:
1829:
1828:
1824:
1821:
1818:
1815:
1812:
1809:
1807:
1804:
1803:
1799:
1796:
1793:
1790:
1787:
1784:
1782:
1779:
1778:
1774:
1771:
1768:
1765:
1762:
1759:
1757:
1754:
1753:
1749:
1746:
1743:
1740:
1737:
1734:
1732:
1729:
1728:
1724:
1721:
1718:
1715:
1712:
1709:
1707:
1704:
1703:
1699:
1696:
1693:
1690:
1687:
1684:
1682:
1679:
1678:
1674:
1671:
1668:
1665:
1662:
1659:
1657:
1654:
1653:
1649:
1646:
1643:
1640:
1637:
1634:
1632:
1629:
1628:
1624:
1621:
1618:
1615:
1612:
1609:
1607:
1604:
1603:
1599:
1596:
1593:
1590:
1587:
1584:
1582:
1579:
1578:
1574:
1571:
1568:
1565:
1562:
1559:
1557:
1554:
1553:
1549:
1546:
1543:
1540:
1537:
1534:
1532:
1529:
1528:
1524:
1521:
1518:
1515:
1512:
1509:
1507:
1504:
1503:
1499:
1496:
1493:
1490:
1487:
1484:
1482:
1479:
1478:
1474:
1471:
1468:
1465:
1462:
1459:
1457:
1456:17-Epiestriol
1454:
1453:
1449:
1446:
1443:
1440:
1437:
1434:
1432:
1431:16-Epiestriol
1429:
1428:
1424:
1421:
1418:
1416:8.195 (2–42)
1415:
1412:
1410:17α-Estradiol
1409:
1407:
1404:
1403:
1399:
1396:
1393:
1390:
1387:
1384:
1382:
1379:
1378:
1374:
1371:
1368:
1365:
1362:
1359:
1357:
1354:
1353:
1349:
1346:
1343:
1340:
1337:
1334:
1331:
1330:
1326:
1323:
1320:
1317:
1314:
1311:
1309:
1306:
1305:
1302:
1299:
1297:
1294:
1292:
1289:
1287:
1284:
1283:
1272:
1267:(RBA, %)
1266:
1258:
1254:
1245:
1240:
1238:
1233:
1231:
1226:
1225:
1221:
1219:
1215:
1211:
1208:
1204:
1203:
1198:
1194:
1190:
1189:
1184:
1180:
1175:
1171:
1167:
1163:
1159:
1155:
1151:
1147:
1143:
1123:
1121:
1117:
1113:
1109:
1105:
1101:
1097:
1093:
1088:
1078:
1074:
1072:
1068:
1064:
1060:
1056:
1053:
1049:
1046:
1042:
1038:
1037:suppositories
1034:
1031:
1027:
1026:oil solutions
1023:
1019:
1013:
1009:
999:
997:
993:
989:
985:
980:
978:
974:
970:
966:
962:
958:
953:
951:
947:
944:
940:
936:
932:
931:breast cancer
928:
924:
920:
916:
912:
908:
904:
900:
896:
892:
888:
884:
883:intramuscular
874:
870:
868:
864:
860:
856:
852:
848:
845:
841:
837:
833:
829:
825:
821:
817:
813:
809:
805:
801:
797:
793:
789:
787:
783:
779:
776:; brand name
775:
771:
767:
763:
759:
755:
751:
747:
744:
740:
736:
732:
728:
724:
721:
717:
713:
709:
705:
701:
697:
687:
680:
671:
666:
665:
662:
655:
646:
645:
642:
635:
631:
629:
628:Melting point
625:
618:
614:
613:
611:
608:
603:
596:
594:
590:
569:
567:
563:
558:
551:
547:
546:
544:
542:
538:
531:
527:
526:
524:
522:
518:
511:
507:
506:
504:
502:
498:
491:
487:
486:
484:
482:
478:
471:
467:
466:
464:
462:
458:
451:
447:
446:
444:
442:
438:
431:
427:
426:
424:
422:
418:
411:
407:
406:
404:
397:
393:
386:
382:
381:
379:
377:
373:
365:
361:
357:
353:
349:
344:
343:
340:
333:
328:
325:
322:
320:
316:
309:
304:
302:
295:
290:
285:
280:
276:
274:
270:
266:
262:
258:
257:hydroxylation
254:
251:
249:
245:
233:
227:
225:
221:
217:
214:
212:
208:
204:
200:
194:
184:
183:
181:
179:
175:
170:
162:
157:
151:
146:
143:
142:
140:
138:
134:
131:
128:
126:
122:
118:
111:
105:
101:
97:
94:
92:
86:
82:
78:
74:
72:
68:
65:Clinical data
63:
59:
54:
50:
45:
37:
33:
19:
14588:
14578:
14502:Mepitiostane
14450:Epitiostanol
14319:Ormeloxifene
14244:Lasofoxifene
14154:Camizestrant
14149:Broparestrol
14139:Bazedoxifene
14061:rotundifuran
14010:alkylphenols
13960:β-zearalenol
13956:α-zearalenol
13942:stigmasterol
13934:β-sitosterol
13930:Phytosterols
13898:triclocarban
13894:methoxychlor
13847:
13829:Lavender oil
13823:tectorigenin
13755:formononetin
13629:
13604:
13475:
13467:
13267:
13251:Quinestradol
13241:Promestriene
13216:Noretynodrel
13080:Estromustine
13033:Estramustine
12968:
12875:testosterone
12612:
12465:
12450:
12410:Progestogens
12313:testosterone
12273:
12258:
12252:Testolactone
12243:
12222:
12207:
12181:Ormeloxifene
12176:Mepitiostane
12171:Lasofoxifene
12166:Epitiostanol
12146:Broparestrol
12141:Bazedoxifene
12029:bicalutamide
11895:
11884:Quinestradol
11879:Promestriene
11802:
11673:noretynodrel
11654:metandienone
11642:testosterone
11624:
11526:
11522:
11495:
11458:
11454:
11448:
11413:
11409:
11399:
11390:
11381:
11361:
11354:
11334:
11327:
11307:
11300:
11291:
11271:
11267:
11261:
11239:(20): 1815.
11236:
11232:
11226:
11206:
11199:
11172:
11168:
11128:
11124:
11090:
11086:
11080:
11072:
11057:
11050:
11030:
11001:
10991:
10969:(4): 291–9.
10966:
10962:
10924:
10920:
10910:
10901:
10886:
10879:
10852:
10848:
10838:
10813:
10809:
10803:
10768:
10764:
10754:
10727:
10683:
10679:
10673:
10649:(1): 76–86.
10646:
10642:
10632:
10623:
10606:(3): 25–29.
10603:
10599:
10586:
10559:
10555:
10545:
10537:
10507:
10503:
10493:
10468:
10464:
10457:
10443:(1): 36–41.
10440:
10436:
10430:
10389:
10385:
10379:
10344:
10340:
10330:
10308:(4): 592–6.
10305:
10301:
10263:
10259:
10213:(3): 241–9.
10210:
10206:
10160:(9): 747–9.
10157:
10153:
10117:
10113:
10080:
10045:
10041:
10035:
10010:
10006:
10000:
9967:
9963:
9953:
9918:
9914:
9904:
9885:
9847:
9843:
9809:(13): 1027.
9806:
9802:
9761:(19): 1466.
9758:
9754:
9702:
9698:
9654:
9650:
9644:
9622:(14): 1175.
9619:
9615:
9609:
9587:(1): 28–35.
9584:
9580:
9574:
9547:
9543:
9503:
9499:
9478:
9463:
9456:
9419:
9415:
9405:
9397:
9372:(3): 206–9.
9369:
9365:
9359:
9351:
9337:
9331:
9311:
9304:
9285:
9275:
9256:
9246:
9222:
9215:
9196:
9162:
9114:
9104:
9079:
9075:
9055:to response.
9053:
9038:
9031:
9012:
9002:
8982:
8974:
8960:
8911:
8884:. Retrieved
8880:the original
8837:
8800:
8796:
8768:
8753:
8712:
8682:
8645:
8611:
8564:
8523:
8490:
8447:
8443:
8332:
8290:
8250:
8215:
8157:gonadotropin
8153:vaginal ring
8150:
8110:
8093:Availability
8087:
8083:progesterone
8079:
8069:
8052:
7991:generic name
7986:
7985:
7970:
7932:
7924:
7916:
7908:
7896:
7872:
7864:
7856:
7822:
7768:
7762:
7760:
7753:
7751:
7747:
7733:double bonds
7720:
7666:Estrone (E1)
7570:
7561:vaginal ring
7558:
7526:
7466:hydroxylated
7438:
7426:
7368:Description:
7367:
7353:unidentified
7339:unidentified
7334:
7331:
7301:
7298:
7277:
7274:
7229:
7226:
7202:
7178:
7164:
7152:
7055:
7052:Distribution
7046:
7030:parenterally
7004:
6985:
6948:of estrogen
6946:Distribution
6927:oil solution
6825:
6779:
6774:
6748:1–2 ≈ 1–4 d
6715:1–2 ≈ 2–3 d
6698:160 ≈ 120 d
6618:5 ≈ 14–24 d
6604:5 ≈ 11–14 d
6451:1–2 ≈ 1–2 d
6353:
6277:= Increased
6263:
6259:
5805:
5732:
5686:tissue, and
5672:pigmentation
5666:, increased
5606:(as well as
5581:
5568:
5556:
5511:
5182:Estriol (E3)
5161:Estrone (E1)
5012:
4935:testosterone
4922:progesterone
4920:(100%) were
4913:
4571:<0.1–0.16
4398:
4380:
4371:
4366:Progestogen
4341:Progestogen
4316:Progestogen
4291:Progestogen
4266:Progestogen
4257:<0.1–0.22
4241:Progestogen
4216:Progestogen
4197:Progesterone
3885:221–>5000
3847:Testosterone
3823:
3794:
3790:Methoxychlor
3762:
3734:
3588:β-Zearalanol
3563:α-Zearalanol
3534:β-Zearalenol
3509:α-Zearalenol
3459:β-Sitosterol
3153:ERβ agonist
3128:ERβ agonist
3103:ERβ agonist
3078:ERβ agonist
3053:ERβ agonist
3028:ERβ agonist
2978:ERα agonist
2953:ERα agonist
2928:ERα agonist
2809:Bazedoxifene
2734:Ormeloxifene
2709:Lasofoxifene
2006:
1200:
1186:
1178:
1139:
1126:Pharmacology
1092:Side effects
1090:
1081:Side effects
1075:
1067:progesterone
1016:Estrone for
1015:
988:hypogonadism
981:
969:progesterone
954:
921:and form of
880:
877:Medical uses
871:
824:bioidentical
792:Side effects
790:
785:
777:
761:
760:(brand name
735:oil solution
711:
707:
703:
699:
695:
694:
683:
363:
359:
355:
351:
347:
298:Elimination
178:Legal status
172:Legal status
36:
14847:Zearalenone
14799:Antagonists
14775:Resveratrol
14740:Nonylphenol
14735:Niacinamide
14651:Bisphenol A
14641:Aldosterone
14470:Glyceollins
14418:Antagonists
14409:Zuclomifene
14404:Zindoxifene
14314:NNC 45-1506
14309:NNC 45-0781
14304:NNC 45-0320
14299:NNC 45-0095
14294:Nitromifene
14274:Miproxifene
14224:Fispemifene
14199:Enclomifene
14194:Droloxifene
14174:CN-55945-27
14119:Afimoxifene
14109:Acefluranol
14000:rhaponticin
13996:resveratrol
13992:Stilbenoids
13964:zearalenone
13952:zearalanone
13938:campesterol
13870:alternariol
13803:pinocembrin
13747:epicatechin
13719:biochanin A
13659:Chalconoids
13553:Terfluranol
13528:Quadrosilan
13400:Elacestrant
13301:Allenestrol
13176:Lynestrenol
13100:Estropipate
13070:Estrofurate
12921:Clomestrone
12901:Atrimustine
12851:Abiraterone
12805:alfatradiol
12499:from market
12396:antagonists
12383:leuprorelin
12362:haloperidol
12358:risperidone
12350:domperidone
12342:antagonists
12325:oxandrolone
12277:Anastrozole
12216:Fulvestrant
12211:Elacestrant
12161:Enclomifene
12104:antagonists
12049:leuprorelin
11992:Quadrosilan
11768:Climacteron
11687:Clomestrone
11628:Alfatradiol
11523:Climacteric
11093:(1): 5–25.
9882:"The Ovary"
8444:Climacteric
8151:An estrone
8133:estropipate
8076:Brand names
7933:Ketodestrin
7877:Parke-Davis
7791:estropipate
7775:synthesized
7571:Estrone is
7440:Estrone is
7415:metabolites
7403:conjugation
6271:hot flashes
5799:hot flashes
5775:transdermal
5753:(non-oral)
5668:sensitivity
5660:enlargement
5648:endometrium
5632:hot flashes
5620:endometrium
5563:(i.e., not
5494:0.01 ± 0.00
5428:0.13 ± 0.04
5384:0.01 ± 0.00
5274:0.05 ± 0.04
5083:Uterotrophy
4974:aldosterone
4718:Alfatradiol
3882:0.0059–0.17
3713:Chlordecone
3659:Bisphenol A
3634:Zearalanone
3609:Zearalenone
3484:Resveratrol
3384:Ipriflavone
3369:0.002–0.040
3259:Biochanin A
3088:WAY-202,196
2959:16α-Iodo-E2
2888:ICI-182,780
2884:Fulvestrant
2859:ICI-164,384
2738:Centchroman
2534:Afimoxifene
2516:3 (0.1–47)
2184:Δ-Estradiol
2013:1-Estradiol
1925:Metabolite
1900:Metabolite
1875:Metabolite
1850:Metabolite
1825:Metabolite
1800:Metabolite
1775:Metabolite
1750:Metabolite
1725:Metabolite
1700:Metabolite
1675:Metabolite
1650:Metabolite
1625:Metabolite
1600:Metabolite
1575:Metabolite
1550:Metabolite
1525:Metabolite
1500:Metabolite
1475:Metabolite
1450:Metabolite
1425:Metabolite
1406:Alfatradiol
1261:Other names
1183:transformed
965:progestogen
903:hot flashes
770:estropipate
600: g·mol
530:CHEBI:17263
330:Identifiers
273:Metabolites
228:96.0–98.0%:
80:Other names
71:Trade names
14902:Categories
14790:Tectoridin
14770:Raloxifene
14745:Oleuropein
14592:Trilostane
14537:Prochloraz
14497:MDL-101906
14492:ICI-164384
14379:Trioxifene
14374:Toremifene
14344:Raloxifene
14329:Panomifene
14324:Ospemifene
14289:Nafoxidine
14179:Cyclofenil
14134:Arzoxifene
14114:Acolbifene
14046:phthalates
14014:bisphenols
13986:miroestrol
13890:methiocarb
13878:endosulfan
13866:Pesticides
13838:enterodiol
13819:tectoridin
13799:penduletin
13795:naringenin
13779:kaempferol
13695:Flavonoids
13689:psoralidin
13685:coumestrol
13681:Coumestans
13645:dianethole
13598:WAY-214156
13588:WAY-200070
13583:WAY-169916
13578:WAY-166818
13548:SKF-82,958
13513:Phenestrol
13493:Methestrol
13478:-Hexestrol
13470:-Butestrol
13351:Dienestrol
13331:Carbestrol
13316:Bifluranol
13311:Benzestrol
13256:Quinestrol
13206:Nilestriol
13048:Estrazinol
12981:Epimestrol
12971:-Estradiol
12953:Cyclotriol
12891:nandrolone
12866:Almestrone
12701:7-Oxo-DHEA
12613:Steroidal:
12585:modulators
12459:Gestrinone
12400:cetrorelix
12282:Exemestane
12267:Formestane
12226:Trilostane
12201:Toremifene
12191:Raloxifene
12186:Ospemifene
12156:Cyclofenil
12131:Acolbifene
11914:Dienestrol
11904:Bifluranol
11899:Benzestrol
11889:Quinestrol
11857:Nilestriol
11712:Epimestrol
11707:Epiestriol
11665:progestins
11625:Steroidal:
11131:(9): 667.
8268:0471238961
8189:References
8097:See also:
7917:Folliculin
7909:Oestroform
7855:including
7845:scientific
7817:See also:
7773:have been
7611:See also:
7442:conjugated
7382:and other
7376:metabolism
7076:Metabolism
7014:micronized
7001:Absorption
6806:epithelium
6585:10 ≈ 21 d
6545:5 ≈ 5–8 d
5815:antagonize
5751:parenteral
5704:congestion
5608:flaccidity
5596:amenorrhea
5565:endogenous
5557:Footnotes:
5095:levels (%)
4916:Reference
4746:Epiestriol
4372:Footnotes:
4297:Δ-Tibolone
4129:<0.0001
3932:0.019–0.07
3897:Nandrolone
3744:0.0073–0.4
3716:0.0069–0.2
3684:Endosulfan
3409:Miroestrol
3309:Naringenin
3284:Kaempferol
3159:Coumestrol
3059:Prinaberel
2784:Ospemifene
2713:CP-336,156
2688:LY-353,381
2684:Arzoxifene
2672:0.188–0.52
2659:Raloxifene
2634:Nafoxidine
2609:Cyclofenil
2559:Toremifene
2513:ICI-46,474
2384:Dienestrol
2019:9.44–80.07
2016:1.31–12.34
2009:-Estradiol
1563:13 (8–70)
1538:0.0027–2.0
1513:22 (7–81)
1210:antagonize
1085:See also:
1006:See also:
844:endogenous
605:3D model (
593:Molar mass
550:ChEMBL1405
490:2DI9HA706A
461:ChemSpider
421:IUPHAR/BPS
376:CAS Number
339:IUPAC name
248:Metabolism
218:: very low
125:Drug class
18:Andrestraq
14928:Estrogens
14785:Tamoxifen
14765:Quercetin
14705:Genistein
14685:Estradiol
14669:o',p'-DDE
14572:ZK-191703
14567:ZK-164015
14527:Phenytoin
14425:(R,R)-THC
14364:Tamoxifen
14339:Promensil
14264:LY-117018
14239:Idoxifene
14234:ICI-55548
14219:Femarelle
14204:Endoxifen
14164:Clomifene
13920:diosgenin
13916:digitalis
13912:digitoxin
13902:triclosan
13882:fenarimol
13815:quercetin
13791:myricetin
13787:mirificin
13775:glycitein
13767:genistein
13763:glabridin
13723:calycosin
13711:baicalein
13667:phloretin
13623:ZK-283197
13483:Mestilbol
13445:Hexestrol
13420:Fenestrel
13395:Efavirenz
13326:Butestrol
13281:2,8-DHHHC
13276:(S,S)-THC
13271:(R,R)-THC
13226:Pentolame
13221:Orestrate
13196:Moxestrol
13186:Mestranol
13151:Etynodiol
13011:Estradiol
12986:Equilenin
12948:Cyclodiol
12906:Bolandiol
12509:Phase III
12497:Withdrawn
12387:goserelin
12370:sulpiride
12346:prolactin
12305:Androgens
12287:Letrozole
12262:Fadrozole
12196:Tamoxifen
12151:Clomifene
11958:Hexestrol
11852:Moxestrol
11842:Mestranol
11727:Estradiol
11634:androgens
11602:Estrogens
11590:Estrogens
11391:Drugs.com
11253:0098-7484
11145:0002-9955
10963:Maturitas
10620:248135901
10042:Maturitas
9823:0002-9955
9775:0002-9955
9719:1535-3702
9671:0095-9561
9636:0098-7484
9520:0021-972X
9257:Menopause
9232:cite book
9159:"Estrone"
9096:0002-9955
8253:. Wiley.
7973:by 1944.
7925:Menformon
7883:, and/or
7881:placentas
7823:In 1927,
7704:Note the
7672:Estradiol
7607:Chemistry
7567:Excretion
7554:inhibitor
7552:17β-HSD1
7550:selective
7546:exogenous
7522:17β-HSD12
7407:sulfation
7387:estrogens
7380:estradiol
7134:Estradiol
7119:in humans
7117:estradiol
6892:estradiol
6795:Estradiol
6758:Aq. soln.
6739:Oil soln.
6720:Aq. susp.
6706:Oil soln.
6687:Aq. soln.
6666:Oil soln.
6647:Oil soln.
6628:Oil soln.
6609:Aq. susp.
6595:Oil soln.
6576:Oil soln.
6555:Oil soln.
6536:Oil soln.
6503:Aq. susp.
6489:Oil soln.
6479:1 ≈ 30 d
6470:Microsph.
6456:Aq. susp.
6442:Oil soln.
6428:Aq. soln.
6424:Estradiol
6403:Dose (mg)
6101:0.56–1.7
5961:Estradiol
5812:partially
5803:cell-free
5771:pregnancy
5561:Synthetic
5551:levels =
5472:0.9 ± 0.3
5450:2.8 ± 1.0
5362:1.9 ± 0.8
5318:1.3 ± 0.2
5230:4.2 ± 0.8
5208:0.5 ± 0.2
4948:estradiol
4858:Moxestrol
4802:Mestranol
4524:Estradiol
4357:0.070–0.1
4282:0.2–0.076
4191:Estrogen
4166:Estrogen
4141:Androgen
4116:Androgen
4113:>10000
4110:>10000
4091:Androgen
4088:>10000
4085:>10000
4066:Androgen
4041:Androgen
4016:Androgen
4013:>10000
4010:>10000
3991:Androgen
3966:Androgen
3941:Androgen
3916:Androgen
3891:Androgen
3866:Androgen
3803:0.01–0.13
3584:Taleranol
3359:Quercetin
3216:0.2–0.287
3184:Genistein
3175:0.07–27.0
3172:0.14–80.0
3109:Erteberel
3016:0.12–0.25
2794:0.59–1.22
2791:0.82–2.63
2638:U-11,000A
2584:Clomifene
2572:7.14–20.3
2509:Tamoxifen
2503:Estrogen
2478:Estrogen
2453:Estrogen
2428:Estrogen
2403:Estrogen
2378:Estrogen
2359:Hexestrol
2353:Estrogen
2328:Estrogen
2303:Estrogen
2284:Moxestrol
2278:Estrogen
2259:Mestranol
2253:Estrogen
2250:0.29–0.81
2247:0.02–0.05
2228:Estrogen
2209:Δ-Estrone
2203:Estrogen
2178:Estrogen
2153:Estrogen
2128:Estrogen
2103:Estrogen
2078:Estrogen
2059:Equilenin
2053:Estrogen
2028:Estrogen
2000:Estrogen
1975:Estrogen
1950:Estrogen
1885:E2-3G-17S
1400:Estrogen
1375:Estrogen
1350:Estrogen
1327:Estrogen
1308:Estradiol
1207:partially
1059:estradiol
925:to treat
859:converted
855:estradiol
847:estradiol
840:estrogens
741:and as a
737:given by
319:Excretion
300:half-life
279:Estradiol
261:sulfation
89:Routes of
14923:Estranes
14863:See also
14665:p,p'-DDT
14656:Daidzein
14646:Atrazine
14619:Agonists
14547:RU-58668
14542:RU-39411
14389:U-11555A
14384:TZE-5323
14129:Anordrin
14124:Anordiol
14057:agnuside
14034:parabens
13874:dieldrin
13846:nyasol (
13811:puerarin
13807:prunetin
13771:genistin
13759:glabrene
13731:daidzein
13727:catechin
13715:baicalin
13707:apigenin
13637:anethole
13425:FERb 033
13261:Tibolone
13246:RU-16117
13231:Prodiame
13166:Hippulin
13161:Hexolame
13006:Estetrol
12916:Butolame
12606:Agonists
12521:See also
12404:elagolix
12379:agonists
12339:receptor
12136:Anordrin
12038:agonists
11722:Estetrol
11681:tibolone
11663:Certain
11632:Certain
11618:agonists
11551:24616324
11543:16112947
11475:14862159
11440:20781420
11410:Br Med J
11288:20988414
11191:29648134
10943:18183589
10871:14367392
10830:13491750
10795:13463090
10708:35732314
10700:20645882
10534:13638626
10504:Br Med J
10449:15771561
10422:38877163
10414:16399916
10371:26023144
10235:26077537
10182:13617050
10174:26190536
10027:21195753
9992:12387416
9864:16554039
9727:75441739
9601:14907837
9566:18731134
9448:17634106
9394:22216977
9386:19232600
9082:(1): 1.
8819:18744783
8472:24616324
8464:16112947
8167:See also
8147:Research
8053:Oestrone
7997:and its
7937:ampoules
7869:Schering
7865:Progynon
7857:Amniotin
7849:clinical
7841:pregnant
7833:excreted
7706:hydroxyl
7688:Estetrol
7583:such as
7573:excreted
7518:17β-HSD8
7514:17β-HSD7
7510:17β-HSD4
7506:17β-HSD3
7502:17β-HSD1
7498:isoforms
7484:or into
7476:such as
7448:such as
7427:Sources:
7419:hydroxyl
6986:Sources:
6960:after a
6826:Sources:
6517:Emulsion
6437:<1 d
6397:Estrogen
6354:Sources:
6324:levels.
6311:levels.
6249:5.7–7.5
6212:2.9–5.0
6138:1.3–4.5
5851:Estrogen
5807:in-vitro
5797:such as
5680:tingling
5664:fullness
5569:Sources:
5500:Inactive
5462:<0.5
5453:552 ± 42
5390:Inactive
5368:Inactive
5340:180 ± 43
5280:Inactive
5214:Inactive
5189:468 ± 30
5167:490 ± 22
5147:506 ± 20
5053:Estrogen
5013:Sources:
5000:cortisol
4976:for the
4963:for the
4950:for the
4937:for the
4924:for the
4908:<0.1
4880:<0.1
4824:<0.1
4796:<0.1
4684:<0.1
4628:<0.1
4574:<0.1
4546:<0.1
4439:Estrogen
4399:Sources:
4382:in-vitro
4272:Tibolone
4157:<0.07
4107:<0.01
4104:<0.01
4082:<0.01
4079:<0.01
4051:3β-Adiol
4026:3α-Adiol
4007:<0.01
4004:<0.01
3935:245–1053
3863:>5000
3860:>5000
3694:<0.01
3394:<0.01
3391:<0.01
3234:Daidzein
3200:0.3–12.8
2834:Etacstil
2716:10.2–166
2550:0.04–4.8
2522:3.4–9.69
1760:4-MeO-E3
1685:4-MeO-E1
1635:2-MeO-E1
1585:4-MeO-E2
1535:2-MeO-E2
1422:0.43–1.2
1419:0.2–0.52
1381:Estetrol
1202:in vitro
1179:in vitro
1177:the ERs
1104:headache
1071:ampoules
967:such as
950:duration
941:(namely
901:such as
895:symptoms
891:estrogen
851:activity
804:headache
786:Premarin
766:prodrugs
762:Hormonin
754:by mouth
748:applied
716:estrogen
704:Estragyn
686:(verify)
441:DrugBank
292:• Others
137:ATC code
130:Estrogen
109:E2/E1/E3
104:by mouth
14933:Ketones
14918:Sterols
14913:Phenols
14835:Unknown
14811:Estriol
14715:GPER-L2
14710:GPER-L1
14394:U-11634
14269:Menerba
14259:LN-2299
14254:LN-1643
14229:GW-7604
14184:D-15413
14016:(e.g.,
14008:(e.g.,
13994:(e.g.,
13978:Steroid
13950:(e.g.,
13932:(e.g.,
13910:(e.g.,
13868:(e.g.,
13860:cadmium
13858:(e.g.,
13836:(e.g.,
13834:Lignans
13735:daidzin
13699:7,8-DHF
13697:(incl.
13683:(e.g.,
13661:(e.g.,
13543:SERBA-2
13538:SC-4289
13533:SC-3296
13440:GTx-758
13336:D-15414
13286:β-LGND1
13236:Prolame
13085:Estrone
13053:Estriol
12991:Equilin
12873:(e.g.,
12786:16α-LE2
12454:Danazol
12412:(e.g.,
12398:(e.g.,
12381:(e.g.,
12311:(e.g.,
12106:(incl.
12057:(e.g.,
12040:(e.g.,
12027:(e.g.,
12007:Zeranol
11803:Estrone
11786:(e.g.,
11779:Estriol
11734:(e.g.,
11667:(e.g.,
11640:(e.g.,
11431:2086334
11182:5303355
11107:6277697
10983:7231201
10786:1072719
10665:6847874
10525:1993181
10485:3080464
10394:Bibcode
10362:4485017
10322:6818806
10280:2992279
10227:2512035
10136:6863280
10062:2170822
9972:Bibcode
9945:9294720
9936:1470103
9557:1642736
9439:1933435
8886:21 June
8810:1659459
8117:Georgia
8070:estrone
7989:is the
7987:Estrone
7960:vaginal
7956:tablets
7931:), and
7929:Organon
7921:Organon
7897:Estrone
7873:Theelin
7871:), and
7835:in the
7813:History
7748:estrone
7729:steroid
7726:estrane
7680:Estriol
7593:labeled
7486:estriol
7405:(e.g.,
7395:estriol
7391:estrone
7389:(e.g.,
7384:natural
7346:17β-HSD
7236:17β-HSD
7215:Estriol
7166:Estrone
7070:albumin
7058:tissues
6974:uterine
6958:tissues
6881:vaginal
6803:vaginal
6786:are of
6735:Estriol
6703:Estrone
6231:2.9–3.4
6206:500–600
6203:500–600
6132:1.3–1.5
6129:3.0–3.2
6120:1.1–1.3
6098:1.4–1.5
6095:0.5–0.7
6083:0.8–0.9
6033:Estriol
5997:Estrone
5779:potency
5612:nipples
5604:breasts
5602:of the
5600:atrophy
5534:cytosol
5531:uterine
5529:of rat
5387:103 ± 7
5371:110–142
5365:130 ± 9
5296:45 ± 12
5255:285 ± 8
5119:Control
4918:ligands
4905:<0.1
4877:<0.2
4874:<0.1
4865:<0.1
4821:<0.1
4778:100–112
4690:Equilin
4681:<0.1
4662:Estriol
4607:Estrone
4387:labeled
4332:0.6–0.8
3938:163–515
3888:73–1688
3829:1.2–1.7
3826:-OH-DDT
3559:Zeranol
3197:2.6–126
3134:SERBA-2
3084:ERB-196
3044:22.0–83
2941:14.6–57
2934:16α-LE2
2838:GW-5638
2641:30.9–44
2616:151–152
2094:7.9–108
2091:7.9–113
2044:13.0–49
2034:Equilin
1735:2-OH-E3
1713:2.0–6.5
1663:1.0–2.0
1660:4-OH-E1
1616:0.2–0.4
1613:2.0–4.0
1610:2-OH-E1
1560:4-OH-E2
1510:2-OH-E2
1356:Estriol
1332:Estrone
1280:Action
1216:of the
1197:prodrug
1188:in vivo
1166:estriol
1144:of the
1142:agonist
1063:estriol
1048:tablets
1030:vaginal
1024:and/or
935:potency
887:vaginal
867:prodrug
863:potency
830:of the
828:agonist
743:vaginal
712:Theelin
708:Kestrin
696:Estrone
598:270.372
566:Formula
450:DB00655
396:PubChem
385:53-16-7
232:Albumin
158: (
156:G03CC04
153:)
147: (
145:G03CA07
100:vaginal
32:Estrone
14730:Niacin
14725:Kepone
14582:ERX-11
14552:SS1020
14460:ERB-88
14455:ERA-90
14359:SS1010
14284:MRL-37
13649:dianol
13618:ERB-79
13613:ERA-45
13608:ERB-26
13341:DCW234
13296:AC-186
12963:DHEA-S
12895:esters
12879:esters
12731:8β-VE2
12492:WHO-EM
12444:Others
11549:
11541:
11503:
11473:
11455:Lancet
11438:
11428:
11369:
11342:
11315:
11286:
11251:
11214:
11189:
11179:
11143:
11105:
11065:
11038:
11008:
10981:
10941:
10894:
10869:
10828:
10793:
10783:
10742:
10706:
10698:
10663:
10618:
10578:908445
10576:
10532:
10522:
10483:
10447:
10420:
10412:
10369:
10359:
10320:
10278:
10233:
10225:
10180:
10172:
10134:
10088:
10060:
10025:
9990:
9943:
9933:
9892:
9862:
9821:
9773:
9725:
9717:
9669:
9634:
9599:
9564:
9554:
9518:
9471:
9446:
9436:
9392:
9384:
9344:
9319:
9292:
9263:
9203:
9169:
9121:
9094:
9046:
9019:
8990:
8926:
8845:
8817:
8807:
8761:
8727:
8689:
8653:
8619:
8572:
8530:
8498:
8470:
8462:
8339:
8305:
8265:
8223:
8125:Taiwan
8123:, and
8121:Monaco
8113:Canada
8105:, and
8042:, and
7958:, and
7901:Abbott
7861:Squibb
7805:, and
7789:, and
7741:ketone
7710:groups
7708:(–OH)
7615:, and
7520:, and
7423:groups
7421:(–OH)
7317:CYP450
7293:CYP450
7284:CYP450
7269:UGT1A9
7263:UGT1A3
7040:. The
6780:Notes:
6340:, and
6260:Notes:
6194:60–150
5755:routes
5712:cramps
5696:growth
5656:libido
5652:uterus
5646:, and
5644:cervix
5626:, and
5618:, and
5616:vagina
5512:Notes:
5406:11 ± 4
5393:95–100
5252:24 ± 7
5186:10 ± 4
5164:11 ± 8
4998:, and
4914:Notes:
4543:8.7–12
4374:= (1)
3709:Kepone
3566:48–111
3034:8β-VE2
3019:6.6–18
2588:MRL-41
2394:56–404
2369:60–234
2144:90–100
2069:7.0–20
2066:2.0–15
1960:E2-17B
1922:>10
1919:>10
1888:0.0001
1863:0.0015
1860:E2-17G
1838:0.0079
1813:0.0004
1257:Ligand
1214:ligand
1158:potent
1148:(ERs)
1114:, and
1108:nausea
1055:tablet
1033:creams
994:, and
977:cancer
961:uterus
834:, the
814:, and
808:nausea
780:) and
710:, and
641:SMILES
541:ChEMBL
510:D00067
240:: ~16%
234:: ~80%
193:℞-only
191:
115:or as
14806:CCL18
14680:Equol
14562:ZB716
14532:PHTPP
14399:Y-134
14076:SERMs
14071:Mixed
13751:equol
13633:Anise
13462:M2613
12118:SERDs
12109:SERMs
11547:S2CID
11519:(PDF)
10704:S2CID
10616:S2CID
10596:(PDF)
10418:S2CID
10231:S2CID
10178:S2CID
9723:S2CID
9422:: 7.
9390:S2CID
8952:(PDF)
8468:S2CID
8440:(PDF)
7905:Lilly
7837:urine
7744:group
7731:with
7597:feces
7577:urine
7490:liver
7444:into
6954:blood
6903:cells
6879:Mean
6690:40–60
6598:20–30
6558:20–30
6539:25–30
6492:25–35
6445:40–60
6243:25–37
6240:26–28
6064:0.67
5954:Liver
5437:65–92
5415:21–50
5261:31–61
5153:12–19
4846:<1
4790:<1
4784:15–25
4762:<1
4759:<1
4756:<1
4753:<1
4734:<1
4731:<1
4728:<1
4725:<1
4678:<1
4675:<1
4672:<1
4669:<1
4666:10–15
4622:<1
4619:<1
4616:<1
4613:<1
4610:11–35
3209:Equol
3069:67–72
2944:0.089
2853:SERM
2828:SERM
2822:0.053
2803:SERM
2778:SERM
2753:SERM
2747:0.313
2728:SERM
2722:0.229
2703:SERM
2697:0.179
2678:SERM
2653:SERM
2628:SERM
2603:SERM
2578:SERM
2553:SERM
2528:SERM
2466:0.074
2447:15.30
2291:35–43
2141:35–68
2119:14–32
1988:0.145
1916:<1
1913:<1
1835:E2-3G
1791:<1
1788:<1
1691:<1
1688:<1
1641:<1
1516:11–35
1466:79–80
1277:, nM)
1116:edema
853:than
842:like
816:edema
768:like
746:cream
661:InChI
607:JSmol
521:ChEBI
324:Urine
255:(via
253:Liver
14826:MIBE
14821:G-36
14816:G-15
14750:PCBs
14607:GPER
14517:MIBE
14050:PCBs
14042:PHBA
14038:PBBs
13886:HPTE
13743:EGCG
13641:anol
13476:meso
13468:meso
12958:DHEA
12893:and
12877:and
12394:GnRH
12377:GnRH
12043:GnRH
12036:GnRH
11592:and
11539:PMID
11501:ISBN
11471:PMID
11436:PMID
11367:ISBN
11340:ISBN
11313:ISBN
11284:PMID
11249:ISSN
11212:ISBN
11187:PMID
11141:ISSN
11103:PMID
11063:ISBN
11036:ISBN
11006:ISBN
10979:PMID
10939:PMID
10892:ISBN
10867:PMID
10826:PMID
10791:PMID
10740:ISBN
10696:PMID
10661:PMID
10574:PMID
10530:PMID
10481:PMID
10445:PMID
10410:PMID
10390:1057
10367:PMID
10318:PMID
10276:PMID
10223:PMID
10170:PMID
10132:PMID
10086:ISBN
10058:PMID
10023:PMID
9988:PMID
9941:PMID
9890:ISBN
9860:PMID
9819:ISSN
9771:ISSN
9715:ISSN
9667:ISSN
9632:ISSN
9597:PMID
9562:PMID
9516:ISSN
9469:ISBN
9444:PMID
9382:PMID
9342:ISBN
9317:ISBN
9290:ISBN
9261:ISBN
9238:link
9201:ISBN
9167:ISBN
9119:ISBN
9092:ISSN
9044:ISBN
9017:ISBN
8988:ISBN
8924:ISBN
8888:2018
8843:ISBN
8815:PMID
8759:ISBN
8725:ISBN
8687:ISBN
8651:ISBN
8617:ISBN
8570:ISBN
8528:ISBN
8496:ISBN
8460:PMID
8337:ISBN
8303:ISBN
8263:ISBN
8221:ISBN
8036:DCIT
7953:oral
7947:for
7847:and
7827:and
7754:estr
7690:(E4)
7682:(E3)
7674:(E2)
7587:and
7527:The
7480:and
7460:and
7452:and
7409:and
7370:The
7326:COMT
7308:COMT
7007:oral
6956:and
6782:All
6634:5–10
6417:CICD
6400:Form
6334:SHBG
5992:1.0
5925:SHBG
5785:and
5714:and
5670:and
5636:mood
5459:7–24
5396:120
5286:130
5195:8–18
5156:100
5114:(%)
5100:SHBG
5002:for
4992:SHBG
4989:for
4840:3–25
4793:0.18
4540:0.13
4503:SHBG
4446:(%)
4393:and
4238:1084
4029:0.07
3907:0.23
3904:0.01
3824:p,p'
3818:HPTE
3795:p,p'
3772:0.03
3765:-DDT
3763:p,p'
3737:-DDT
3735:o,p'
3641:0.51
3416:0.39
3338:8-PN
3250:85.3
3150:1.54
3147:14.5
3125:0.19
3122:2.68
3066:0.27
3050:0.50
3047:12.9
3041:0.35
3022:32.4
2994:0.05
2969:2.30
2966:30.2
2947:0.27
2925:92.8
2922:0.40
2919:0.12
2897:0.42
2875:0.08
2844:11.5
2841:4.30
2769:1.88
2766:1.55
2719:19.0
2675:20.2
2575:15.4
2491:2.69
2488:TPBE
2441:1.74
2438:TACE
2400:0.03
2397:0.05
2375:0.06
2372:0.06
2350:0.05
2347:0.04
2294:5–20
2225:0.57
2222:0.52
2200:0.25
2197:0.15
2175:0.37
2172:0.50
2150:0.20
2147:0.15
2125:0.57
2122:0.24
2100:0.17
2097:0.09
2075:0.62
2072:0.64
2050:0.36
2047:0.79
1966:32.6
1963:11.3
1566:7–56
1152:and
1052:oral
1045:oral
1043:and
1010:and
975:and
948:and
943:oral
937:and
905:and
885:and
822:and
778:Ogen
501:KEGG
481:UNII
470:5660
430:2818
410:5870
238:SHBG
216:Oral
205:data
106:(as
14780:STX
14700:G-1
14661:DDT
14482:III
14030:DDT
14028:),
14026:BPS
14022:BPF
14018:BPA
13918:),
13848:cis
13739:ECG
12969:ent
12060:FSH
11531:doi
11463:doi
11426:PMC
11418:doi
11276:doi
11241:doi
11237:104
11177:PMC
11133:doi
11129:105
11095:doi
10971:doi
10929:doi
10925:122
10857:doi
10853:214
10818:doi
10781:PMC
10773:doi
10732:doi
10688:doi
10651:doi
10608:doi
10564:doi
10520:PMC
10512:doi
10473:doi
10402:doi
10357:PMC
10349:doi
10310:doi
10306:101
10268:doi
10264:152
10215:doi
10162:doi
10122:doi
10118:258
10050:doi
10015:doi
10011:201
9980:doi
9931:PMC
9923:doi
9919:105
9852:doi
9811:doi
9807:109
9763:doi
9759:101
9707:doi
9659:doi
9624:doi
9620:117
9589:doi
9552:PMC
9508:doi
9434:PMC
9424:doi
9374:doi
9370:105
9084:doi
9080:125
8916:doi
8805:PMC
8717:doi
8452:doi
8295:doi
8255:doi
8058:BAN
8045:JAN
8027:DCF
8018:BAN
8009:USP
8000:INN
7943:or
7941:oil
7939:of
7923:),
7915:),
7907:),
7863:),
7839:of
7763:one
7761:ket
7575:in
7540:by
7468:by
7456:by
7378:of
7254:STS
7245:EST
7115:of
7036:or
6929:by
6894:in
6820:of
6812:or
6462:3.5
6412:EPD
6352:).
6342:AGT
6338:CBG
6326:HDL
6305:FSH
6300:FSH
6292:UCa
6287:UCa
6281:of
6209:350
6200:400
6197:100
6191:400
6188:150
6185:120
6172:7.5
6169:6.0
6166:7.5
6163:6.0
6154:1.0
6135:5.0
6126:1.5
6123:1.0
6117:2.0
6114:1.5
6111:1.2
6092:0.9
6089:0.5
6086:0.9
6080:0.9
6077:0.9
6052:0.2
6049:0.3
6046:0.3
6043:0.1
6040:0.3
6037:0.3
6012:0.3
6009:0.3
5989:1.0
5986:1.0
5983:1.0
5980:1.0
5977:1.0
5974:1.0
5971:1.0
5968:1.0
5965:1.0
5945:AGT
5935:CBG
5906:HDL
5886:FSH
5876:UCa
5769:of
5614:),
5582:In
5525:to
5519:RBA
5475:302
5456:+++
5440:12
5431:338
5418:35
5409:351
5346:+++
5321:260
5277:101
5264:28
5192:+++
5176:20
5170:+++
5150:+++
5144:100
5131:100
5125:100
5108:RBA
5079:(%)
5073:(%)
5067:RBA
5005:CBG
4871:3.2
4868:0.8
4843:1–3
4837:1–3
4787:1–3
4781:1–3
4625:2.7
4537:0.6
4534:2.6
4531:7.9
4528:100
4513:CBG
4395:ERβ
4391:ERα
4235:152
4182:5.6
4154:4.0
4035:260
4032:0.3
3982:0.6
3979:0.5
3963:0.9
3960:3.6
3910:765
3688:EDS
3672:195
3663:BPA
3638:ZAN
3613:ZEN
3600:0.9
3597:0.8
3441:2.0
3341:4.4
3275:8.9
3272:174
3247:2.0
3094:180
3025:1.7
3013:DPN
2988:MPP
2950:131
2913:PPT
2900:1.3
2872:0.2
2869:166
2650:0.8
2647:0.3
2619:243
2600:1.2
2597:0.9
2525:2.5
2463:TPE
2416:114
2300:2.6
2297:0.5
2269:2.5
2007:ent
1766:1.0
1763:1.0
1741:1.0
1738:2.0
1666:1.0
1591:1.0
1588:2.0
1572:1.9
1569:1.0
1541:1.0
1522:1.3
1519:2.5
1488:1.0
1394:4.9
1391:3.0
1388:4.0
1318:100
1315:100
1301:ERβ
1296:ERα
1291:ERβ
1286:ERα
1154:ERβ
1150:ERα
952:).
913:or
909:in
897:of
838:of
788:).
756:as
733:or
400:CID
358:,14
354:,13
161:WHO
150:WHO
14904::
14667:,
14486:IV
14484:,
14480:,
14478:II
14476:,
14059:,
14048:,
14044:,
14040:,
14036:,
14032:,
14024:,
14020:,
14012:,
13998:,
13984:,
13970:,
13966:,
13962:,
13958:,
13954:,
13940:,
13936:,
13922:,
13900:,
13896:,
13892:,
13888:,
13884:,
13880:,
13876:,
13872:,
13844:,
13840:,
13821:,
13817:,
13813:,
13809:,
13805:,
13801:,
13797:,
13793:,
13789:,
13785:,
13781:,
13777:,
13773:,
13769:,
13765:,
13761:,
13757:,
13753:,
13749:,
13745:,
13741:,
13737:,
13733:,
13729:,
13725:,
13721:,
13717:,
13713:,
13709:,
13705:,
13701:,
13687:,
13673:,
13669:,
13665:,
13651:,
13647:,
13643:,
13639:,
12889:,
12885:,
12881:,
12594:ER
12505::
12432:,
12428:,
12424:,
12420:,
12416:,
12402:,
12385:,
12368:,
12364:,
12360:,
12356:,
12352:,
12327:,
12323:,
12319:,
12315:,
12098:ER
12069:LH
12066:,
12047:,
11790:,
11770:))
11762:,
11758:,
11754:,
11750:,
11746:,
11742:,
11738:,
11679:,
11675:,
11671:,
11656:,
11652:,
11648:,
11644:,
11612:ER
11545:.
11537:.
11525:.
11521:.
11469:.
11457:.
11434:.
11424:.
11412:.
11408:.
11389:.
11290:.
11282:.
11270:.
11247:.
11235:.
11185:.
11173:43
11171:.
11167:.
11153:^
11139:.
11127:.
11115:^
11101:.
11091:37
11089:.
11071:.
11020:^
10977:.
10965:.
10951:^
10937:.
10923:.
10919:.
10900:.
10865:.
10851:.
10847:.
10824:.
10814:16
10812:.
10789:.
10779:.
10769:36
10767:.
10763:.
10738:.
10716:^
10702:.
10694:.
10684:20
10682:.
10659:.
10647:56
10645:.
10641:.
10622:.
10614:.
10602:.
10598:.
10572:.
10560:28
10558:.
10554:.
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