763:
290:
166:
7294:
449:. Typical cases involve the nitrosylation of heme proteins like cytochromes, thereby disabling the normal enzymatic activity of the enzyme. Nitrosylated ferrous iron is particularly stable. Hemoglobin is a prominent example of a heme protein that may be modified by NO by both direct attack by NO and, independently, via attack by S-nitrosothiols, involving NO transfer from S to Fe.
1577:
who studies "acute respiratory distress" in high altitudes, is applying this research towards COVID-19. He is involved in clinical trials which apply the use of inhaled nitric oxide as a treatment for COVID-19. This approach was inspired by the work of associate professor of emergency medicine at the
1522:
This vasodilation does not decrease the volume of blood the heart pumps, but rather it decreases the force the heart muscle must exert to pump the same volume of blood. Nitroglycerin pills, taken sublingually (under the tongue), are used to prevent or treat acute chest pain. The nitroglycerin reacts
1451:
and releases the active metabolite nitric oxide (NO). As with all supplements of nitric oxide, the response is short-lived because, as a normally produced internal physiologic control mechanism, increased concentrations lead to increased rates of clearance, which is the reason that the effectiveness
742:
can withstand extreme levels of radioactivity and other stresses. In 2009 it was reported that nitric oxide plays an important role in this bacteria's recovery from radiation exposure: The gas is required for division and proliferation after DNA damage has been repaired. A gene that increases nitric
152:
are known for the NOS enzyme: endothelial (eNOS), neuronal (nNOS), and inducible (iNOS) - each with separate functions. The neuronal enzyme (NOS-1) and the endothelial isoform (NOS-3) are calcium-dependent and produce low levels of this gas as a cell signaling molecule. The inducible isoform (NOS-2)
230:
of commensal facultative anaerobic bacteria. This nitrite is swallowed and reacts with acid and reducing substances in the stomach (such as ascorbate) to produce high concentrations of nitric oxide. The purpose of this mechanism to create NO is thought to be both sterilization of swallowed food (to
156:
NOS oxidizes the guanidine group of L-arginine in a process that consumes five electrons and results in the formation of NO with stoichiometric formation of L-citrulline. The process involves the oxidation of NADPH and the reduction of molecular oxygen. The transformation occurs at a catalytic site
1426:
People with diabetes usually have lower levels of nitric oxide than patients without diabetes. Diminished supply of nitric oxide can lead to vascular damage, such as endothelial dysfunction and vascular inflammation. Vascular damage can lead to decreased blood flow to the extremities, causing the
1327:
Inhaled nitric oxide is contraindicated in the treatment of neonates known to be dependent on right-to-left shunting of blood. This is as the nitric oxide decreases the pulmonary circulation's resistance by dilating pulmonary blood vessels. The increased pulmonary return increases pressure in the
274:
A related mechanism is thought to protect the skin from fungal infections, where nitrate in sweat is reduced to nitrite by skin commensal organisms and then to NO on the slightly acidic skin surface. In alternative fashion, nitrite anions on sun-exposed skin may be photolyzed to free nitric oxide
1527:
group (–SH) to produce nitric oxide, which eases the pain by causing vasodilation. There is a potential role for the use of nitric oxide in alleviating bladder contractile dysfunctions, and recent evidence suggests that nitrates may be beneficial for treatment of angina due to reduced myocardial
1289:
as part of the treatment of peri- and post-operative pulmonary hypertension in adults and newborn infants, infants and toddlers, children and adolescents, ages 0–17 years in conjunction to heart surgery, in order to selectively decrease pulmonary arterial pressure and improve right ventricular
161:
and increasing blood flow. NO is also a neurotransmitter and has been associated with neuronal activity and various functions such as avoidance learning. NO also partially mediates macrophage cytotoxicity against microbes and tumor cells. Besides mediating normal functions, NO is implicated in
1294:
In the United States, it is indicated to improve oxygenation and reduce the need for extracorporeal membrane oxygenation in term and near-term (>34 weeks gestation) neonates with hypoxic respiratory failure associated with clinical or echocardiographic evidence of pulmonary hypertension in
553:
Nitric oxide (NO) is a mediator of vasodilation in blood vessels. It is induced by several factors, and once synthesized by eNOS it results in phosphorylation of several proteins that cause smooth muscle relaxation. The vasodilatory actions of nitric oxide play a key role in renal control of
1298:
The most common side effects include thrombocytopenia (low blood platelet counts), hypokalaemia (low blood potassium levels), hypotension (low blood pressure), atelectasis (collapse of the whole, or part of a, lung), and hyperbilirubinaemia (high blood levels of bilirubin).
1384:, which phosphorylates target proteins such as the myosin phosphatase-targeting subunit (MYPT) and the IP3 receptor-associated cGMP kinase substrate (IRAG). In addition, cGMP has been proposed to also cause smooth muscle relaxation indirectly by increasing levels of cAMP.
1498:
drug: It causes vasodilation, which can help with ischemic pain, known as angina, by decreasing the cardiac workload. By dilating (expanding) the arteries, nitric oxide drugs lower arterial pressure and left ventricular filling pressure. Nitric oxide can contribute to
1305:
Nitric oxide can be delivered as a pulse in the beginning of each breath to horses during anaesthesia. This is called PiNO (pulsed inhaled nitric oxide) and results in better matching of ventilation and perfusion and thereby improves the arterial oxygenation.
1468:, although the effects are short-lived and there are no studies demonstrating improved clinical outcomes. It is used on an individualized basis in ICUs as an adjunct to other definitive therapies for reversible causes of hypoxemic respiratory distress.
1590:. Harris noticed that the consequences of high level altitude sickness on the human body mirrored COVID-19's dysfunctional impact on the lungs. His focus on nitric oxide comes from its role in being able to breathe in high altitudes. According to
1314:
There are some associated complaints with utilization of nitric oxide in neonatal patients. Some of them include dose errors associated with the delivery system, headaches associated with environmental exposure of nitric oxide in hospital staff,
4854:
Wiklund M, Kellgren M, Wulcan S, Grubb T, Nyman G (January 2020). "Effects of pulsed inhaled nitric oxide on arterial oxygenation during mechanical ventilation in anaesthetised horses undergoing elective arthroscopy or emergency colic surgery".
5920:
González C, Herradón E, Abalo R, Vera G, Pérez-Nievas BG, Leza JC, et al. (May 2011). "Cannabinoid/agonist WIN 55,212-2 reduces cardiac ischaemia–reperfusion injury in Zucker diabetic fatty rats: role of CB2 receptors and iNOS/eNOS".
479:, which causes reuptake of Ca and the opening of calcium-activated potassium channels. The fall in concentration of Ca ensures that the myosin light-chain kinase (MLCK) can no longer phosphorylate the myosin molecule, thereby stopping the
2809:
Green SJ, Crawford RM, Hockmeyer JT, Meltzer MS, Nacy CA (December 1990). "Leishmania major amastigotes initiate the L-arginine-dependent killing mechanism in IFN-gamma-stimulated macrophages by induction of tumor necrosis factor-alpha".
157:
adjacent to a specific binding site of L-arginine. NO is an important regulator and mediator of numerous processes in the nervous, immune, and cardiovascular systems. These include vascular smooth muscle relaxation, resulting in arterial
1281:
for the treatment of newborn infants ≥34 weeks gestation with hypoxic respiratory failure associated with clinical or echocardiographic evidence of pulmonary hypertension, in order to improve oxygenation and to reduce the need for
4026:
Verma K, Mehta SK, Shekhawat GS (April 2013). "Nitric oxide (NO) counteracts cadmium induced cytotoxic processes mediated by reactive oxygen species (ROS) in
Brassica juncea: cross-talk between ROS, NO and antioxidant responses".
3436:
Kaibori M, Sakitani K, Oda M, Kamiyama Y, Masu Y, Nishizawa M, et al. (June 1999). "Immunosuppressant FK506 inhibits inducible nitric oxide synthase gene expression at a step of NF-kappaB activation in rat hepatocytes".
2003:
Osanai T, Fujiwara N, Saitoh M, Sasaki S, Tomita H, Nakamura M, et al. (2002). "Relationship between salt intake, nitric oxide and asymmetric dimethylarginine and its relevance to patients with end-stage renal disease".
2689:"Neutralization of gamma interferon and tumor necrosis factor alpha blocks in vivo synthesis of nitrogen oxides from L-arginine and protection against Francisella tularensis infection in Mycobacterium bovis BCG-treated mice"
1328:
left atrium, causing closure of the foramen ovale and reducing the blood flow through the ductus arteriosus. Closing these shunts can kill neonates with heart malformations that rely on the right-to-left shunting of blood.
2736:
Kamijo R, Gerecitano J, Shapiro D, Green SJ, Aguet M, Le J, Vilcek J (1995). "Generation of nitric oxide and clearance of interferon-gamma after BCG infection are impaired in mice that lack the interferon-gamma receptor".
3786:
Corpas FJ, Barroso JB, Carreras A, Valderrama R, Palma JM, León AM, et al. (July 2006). "Constitutive arginine-dependent nitric oxide synthase activity in different organs of pea seedlings during plant development".
5876:
Shmist YA, Goncharov I, Eichler M, Shneyvays V, Isaac A, Vogel Z, Shainberg A (February 2006). "Delta-9-tetrahydrocannabinol protects cardiac cells from hypoxia via CB2 receptor activation and nitric oxide production".
362:
and kill other cells. In vitro studies indicate that phagocyte-dependent generation of NO at concentrations greater than 400-500 nM triggers apoptosis in nearby cells and that this effect may act in a manner similar to
1372:(ECS) may, in part, be mediated through its ability to regulate the production and/or release of nitric oxide. It relaxes vascular smooth muscle by binding to the heme moiety of cytosolic guanylate cyclase, activating
2524:
1606:(which increases NO) is a "lifestyle change" that "may also help to reduce SARS-CoV-2 viral load and symptoms of COVID‑19 pneumonia by promoting more efficient antiviral defense mechanisms in the respiratory tract."
2418:
Opländer C, Römer A, Paunel-Görgülü A, Fritsch T, van
Faassen EE, Mürtz M, et al. (June 2012). "Dermal application of nitric oxide in vivo: kinetics, biological responses, and therapeutic potential in humans".
400:
inflammation. Reduced levels of exhaled NO have been associated with exposure to air pollution in cyclists and smokers, but, in general, levels of exhaled nitric oxide are associated with exposure to air pollution.
1402:) by dilating pulmonary vessels in better-ventilated areas of the lung, moving pulmonary blood flow away from lung segments with low ventilation/perfusion (V/Q) ratios toward segments with normal or better ratios.
337:-4 (IL-4) and IL-10 provide weak inhibitory signals. In this way, the immune system may regulate the armamentarium of phagocytes that play a role in inflammation and immune responses. Nitric oxide is secreted as
178:
Exogenous NO sources constitute a powerful way to supplement NO when the body cannot generate enough for normal biological functions. Certain endogenous compounds can act as NO-donors or elicit NO-like reactions
6429:
6595:
259:
detects the bioconversion of plant-derived nitrate into nitric oxide. A rise in salivary levels is indicative of diets rich in leafy vegetables which are often abundant in anti-hypertensive diets such as the
234:
The nitrate-nitrite-nitric oxide pathway elevates nitric oxide through the sequential reduction of dietary nitrate derived from plant-based foods. Nitrate-rich vegetables, in particular leafy greens, such as
6782:
6108:
3400:
Shami PJ, Moore JO, Gockerman JP, Hathorn JW, Misukonis MA, Weinberg JB (August 1995). "Nitric oxide modulation of the growth and differentiation of freshly isolated acute non-lymphocytic leukemia cells".
1852:
Davies SA, Stewart EJ, Huesmann GR, Skaer NJ, Maddrell SH, Tublitz NJ, Dow JA (August 1997). "Neuropeptide stimulation of the nitric oxide signaling pathway in
Drosophila melanogaster Malpighian tubules".
6504:
2764:
Green SJ, Scheller LF, Marletta MA, Seguin MC, Klotz FW, Slayter M, et al. (December 1994). "Nitric oxide: cytokine-regulation of nitric oxide in host resistance to intracellular pathogens".
475:
Guanylate cyclase is a key component of the famous smooth-muscle relaxing properties of NO. It is a heme-containing enzyme that is acted on by NO, which binds to the heme. Cyclic-GMP activates
6866:
6734:
538:
Nitric oxide (NO) contributes to vessel homeostasis by inhibiting vascular smooth muscle contraction and growth, platelet aggregation, and leukocyte adhesion to the endothelium. Humans with
2047:
Liu AH, Bondonno CP, Croft KD, Puddey IB, Woodman RJ, Rich L, et al. (November 2013). "Effects of a nitrate-rich meal on arterial stiffness and blood pressure in healthy volunteers".
6434:
203:, stimulates erections primarily by enhancing signaling through the nitric oxide pathway. Prominent examples are S-nitrosothiols, certain organic nitrates, nitrosylated metal complexes,
6404:
1683:
to hypoxic conditions, as an NOS inhibitor was able to block the THC-induced cardioprotective action. The activation of mainly CB2 receptors and the restoration of iNOS/eNOS cardiac
933:
2855:"Induction of nitric oxide synthase protects against malaria in mice exposed to irradiated Plasmodium berghei infected mosquitoes: involvement of interferon gamma and CD8+ T cells"
1476:
Nitric oxide is absorbed systemically after inhalation. Most of it moves across the pulmonary capillary bed where it combines with hemoglobin that is 60% to 100% oxygen-saturated.
1418:(ECMO). Nitric oxide therapy has the potential to significantly increase the quality of life and, in some cases, save the lives of infants at risk for pulmonary vascular disease.
7003:
6889:
6822:
6689:
5543:
3000:
Wink DA, Kasprzak KS, Maragos CM, Elespuru RK, Misra M, Dunams TM, et al. (November 1991). "DNA deaminating ability and genotoxicity of nitric oxide and its progenitors".
577:. NO contributes to the regulation of cardiac contractility. Emerging evidence suggests that coronary artery disease (CAD) is related to defects in generation or action of NO.
5115:
Kinsella JP, Cutter GR, Walsh WF, Gerstmann DR, Bose CL, Hart C, et al. (July 2006). "Early inhaled nitric oxide therapy in premature newborns with respiratory failure".
2617:"Cellular mechanisms of nonspecific immunity to intracellular infection: cytokine-induced synthesis of toxic nitrogen oxides from L-arginine by macrophages and hepatocytes"
55:
involved in several physiological and pathological processes. It is a powerful vasodilator with a half-life of a few seconds in the blood. Standard pharmaceuticals such as
6961:
6835:
6752:
6394:
1387:
When inhaled, nitric oxide dilates the pulmonary vasculature and, because of efficient scavenging by hemoglobin, has minimal effect on the vasculature of the entire body.
5982:
1452:
of sustained use of nitroglycerin for vasodilation fades to none after hours to days. In the United States, ongoing direct use of nitric oxide use is only approved for
1336:
In the United States, nitric oxide is a gas available in concentrations of only 100 ppm and 800 ppm. Overdosage with inhaled nitric oxide will be seen by elevations in
222:
Dietary nitrate is also an important source of nitric oxide in mammals. Green, leafy vegetables and some root vegetables (such as beetroot) have high concentrations of
6649:
87:
7101:
7008:
6941:
6772:
6639:
6902:
6848:
6711:
6698:
6812:
6273:
5570:
367:
to dampen and reverse inflammatory responses by neutralizing and then speeding the clearance of pro-inflammatory cells from inflamed tissues. However, the role of
275:
radicals by UVA in sunlight. This mechanism may elicit significant changes to the systemic blood circulation in humans and be exploited for therapeutic purposes.
6757:
6489:
2466:
2325:
1830:
226:. When eaten and absorbed into the bloodstream, nitrate is concentrated in saliva (about 10-fold) and is reduced to nitrite on the surface of the tongue by a
6817:
6419:
6389:
888:
6807:
6409:
4819:
Wiklund M, Granswed I, Nyman G (September 2017). "Pulsed inhaled nitric oxide improves arterial oxygenation in colic horses undergoing abdominal surgery".
1319:
associated with acute withdrawal of the drug, hypoxemia associated with acute withdrawal of the drug, and pulmonary edema in patients with CREST syndrome.
743:
oxide production after UV radiation was described, and in the absence of this gene the bacteria were still able to repair DNA damage, but would not grow.
6762:
6414:
6238:
6233:
7047:
6644:
6384:
6253:
6243:
5597:
1479:
Nitrate has been identified as the predominant nitric oxide metabolite excreted in the urine, accounting for >70% of the nitric oxide dose inhaled.
5417:
Moro C, Leeds C, Chess-Williams R (January 2012). "Contractile activity of the bladder urothelium/lamina propria and its regulation by nitric oxide".
822:
6659:
6654:
6484:
585:
In plants, nitric oxide can be produced by any of four routes: (i) L-arginine-dependent nitric oxide synthase, (although the existence of animal NOS
1352:
Nitric oxide production is associated with nonalcoholic fatty liver disease (NAFLD) and is essential for hepatic lipid metabolism under starvation.
4615:
7065:
5975:
1891:
Walker FA (January 2005). "Nitric oxide interaction with insect nitrophorins and thoughts on the electron configuration of the {FeNO}6 complex".
736:
While nitric oxide is typically known to halt bacterial growth as part of an immune response, in one case NO protects a bacterium. The bacterium
2554:
6083:
1368:
Nitric oxide is a cell signaling molecule produced by many cells of the body, and growing evidence suggests that the biological actions of the
4750:
Text was copied from this source which is copyright
European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
2195:"Enhanced vasodilator activity of nitrite in hypertension: critical role for erythrocytic xanthine oxidoreductase and translational potential"
6802:
6787:
6565:
6545:
6514:
6088:
6068:
6063:
6058:
785:
377:
in inflammation is complex with model studies involving viral infection suggesting that this gaseous mediator can also promote inflammation.
3223:
Uehara EU, Shida BD, de Brito CA (November 2015). "Role of nitric oxide in immune responses against viruses: beyond microbicidal activity".
7070:
6861:
6792:
6540:
6519:
2383:
Suschek CV, Opländer C, van
Faassen EE (February 2010). "Non-enzymatic NO production in human skin: effect of UVA on cutaneous NO stores".
1234:
5801:
5729:
2953:"Co-localization of inducible-nitric oxide synthase and Plasmodium berghei in hepatocytes from rats immunized with irradiated sporozoites"
2904:"IFN-gamma inhibits development of Plasmodium berghei exoerythrocytic stages in hepatocytes by an L-arginine-dependent effector mechanism"
7115:
6946:
6679:
6073:
6053:
5250:
Chotigeat U, Khorana M, Kanjanapattanakul W (February 2007). "Inhaled nitric oxide in newborns with severe hypoxic respiratory failure".
251:
persons. For the body to generate nitric oxide through the nitrate-nitrite-nitric oxide pathway, the reduction of nitrate to nitrite (by
1414:
in neonatal patients and post-meconium aspiration related to birth defects. These are often a last-resort gas mixture before the use of
6981:
6976:
6590:
6585:
6509:
6204:
6199:
6194:
6189:
5968:
4635:"Endogenous nitric oxide regulates the recovery of the radiation-resistant bacterium Deinococcus radiodurans from exposure to UV light"
4605:
1377:
5776:
255:, a bacterial enzyme) occurs in the mouth, by commensal bacteria, an obligatory and necessary step. Monitoring nitric oxide status by
6971:
6966:
6956:
6936:
6669:
6184:
5703:
271:
has been shown to eliminate the blood pressure lowering effects of dietary nitrate due to eradication of nitrate-reducing bacteria.
6580:
6494:
6445:
1302:
Nitric oxide was approved for medical use in the United States in
December 1999 and for medical use in the European Union in 2001.
1277:
In the
European Union, nitric oxide in conjunction with ventilatory support and other appropriate active substances, is indicated:
214:
A high salt intake attenuates NO production in patients with essential hypertension, although bioavailability remains unregulated.
4496:"Excess iron stress reduces root tip zone growth through nitric oxide-mediated repression of potassium homeostasis in Arabidopsis"
4396:"Nitric oxide influences auxin signaling through S-nitrosylation of the Arabidopsis TRANSPORT INHIBITOR RESPONSE 1 auxin receptor"
380:
In response, many bacterial pathogens have evolved mechanisms for nitric oxide resistance. Because nitric oxide might serve as an
6767:
6379:
2346:
Bryan NS, Tribble G, Angelov N (2017). "Oral
Microbiome and Nitric Oxide: the Missing Link in the Management of Blood Pressure".
2082:
Lundberg JO, Weitzberg E, Gladwin MT (February 2008). "The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics".
593:, (iii) mitochondrial electron transport chain, or (iv) non-enzymatic reactions. It is a signaling molecule, acts mainly against
5454:"Cholinergic nitric oxide release from the urinary bladder mucosa in cyclophosphamide-induced cystitis of the anaesthetized rat"
4763:
3153:
Hibbs JB, Taintor RR, Vavrin Z, Rachlin EM (November 1988). "Nitric oxide: a cytotoxic activated macrophage effector molecule".
3105:"Threshold effects of nitric oxide-induced toxicity and cellular responses in wild-type and p53-null human lymphoblastoid cells"
6499:
4126:"RAP2.3 negatively regulates nitric oxide biosynthesis and related responses through a rheostat-like mechanism in Arabidopsis"
247:, have been shown to increase cardioprotective levels of nitric oxide with a corresponding reduction in blood pressure in pre-
3489:
3384:
3359:
3275:
2663:
1935:
2236:"Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite"
7314:
5623:
2168:
6744:
4445:"Nitric Oxide, Ethylene, and Auxin Cross Talk Mediates Greening and Plastid Development in Deetiolating Tomato Seedlings"
2496:
1561:
As of April 2020, studies and trials are underway that examine the possible benefits of nitric oxide in the treatment of
1461:
1415:
1391:
1283:
364:
839:
7170:
184:
2580:
Fitzpatrick J, Kim E (August 2015). "Synthetic modeling chemistry of iron-sulfur clusters in nitric oxide signaling".
4347:"NIN-like Protein7 is controlled by oxygen and nitric oxide and contributes to stress tolerance through PROTEOLYSIS6"
1254:
358:
The inducible pathway (iNOS) of nitrogen oxide synthesis in phagocytes can generate large amounts of NO that trigger
191:
serve as vasodilators because they are converted to nitric oxide in the body. The vasodilating antihypertensive drug
119:
1838:
3293:"Subclinical responses in healthy cyclists briefly exposed to traffic-related air pollution: an intervention study"
464:
in peripheral blood mononuclear cells, a transcription factor in iNOS gene expression in response to inflammation.
1410:
Nitric oxide/oxygen blends are used in critical care to promote capillary and pulmonary dilation to treat primary
6399:
1648:
1528:
oxygen consumption both by decreasing preload and afterload and by some direct vasodilation of coronary vessels.
967:
918:
803:
555:
330:
3641:"The neurovascular mechanism of clitoral erection: nitric oxide and cGMP-stimulated activation of BKCa channels"
3571:
Dessy C, Feron O (2004). "Pathophysiological Roles of Nitric Oxide: In the Heart and the
Coronary Vasculature".
7184:
5733:
5548:
4298:"NIN-like protein7 and PROTEOLYSIS6 functional interaction enhances tolerance to sucrose, ABA, and submergence"
1574:
1570:
528:
3690:"Anti-atherosclerotic effect of beta-blocker with nitric oxide-releasing action on the severe atherosclerosis"
1038:
1381:
4394:
Terrile MC, París R, Calderón-Villalobos LI, Iglesias MJ, Lamattina L, Estelle M, Casalongué CA (May 2012).
3600:"Plasma nitric oxide concentrations and nitric oxide synthase gene polymorphisms in coronary artery disease"
3188:
Wallace JL, Ianaro A, Flannigan KL, Cirino G (May 2015). "Gaseous mediators in resolution of inflammation".
7272:
6258:
4795:
1089:
708:
Blood-sucking insects exploit vasodilation induced by NO to ensure their blood meal. These insects include
169:
Pathway for nitrosylation of heme-thiolate, steps in cell signalling (porphyrin is depicted as the square).
4947:
Fang FC (October 2004). "Antimicrobial reactive oxygen and nitrogen species: concepts and controversies".
4075:"Nitric oxide sensing in plants is mediated by proteolytic control of group VII ERF transcription factors"
1165:
162:
pathophysiologic states as diverse as septic shock, hypertension, stroke, and neurodegenerative diseases.
7319:
7120:
6931:
6144:
4789:
1652:
1565:. This research is based on the fact that nitric oxide was investigated as an experimental therapy for
7284:
6268:
5318:
4900:"Genetic ablation of solute carrier family 7a3a leads to hepatic steatosis in zebrafish during fasting"
4073:
Gibbs DJ, Md Isa N, Movahedi M, Lozano-Juste J, Mendiondo GM, Berckhan S, et al. (February 2014).
3838:
Valderrama R, Corpas FJ, Carreras A, Fernández-Ocaña A, Chaki M, Luque F, et al. (February 2007).
3737:
Corpas FJ, Barroso JB, Carreras A, Quirós M, León AM, Romero-Puertas MC, et al. (September 2004).
605:
351:; the mechanism for this includes DNA damage and degradation of iron sulfur centers into iron ions and
6154:
6042:
4990:
Goldfarb RD, Cinel I (January 2007). "Inhaled nitric oxide therapy for sepsis: more than just lung".
4735:
4237:
Vicente J, Mendiondo GM, Movahedi M, Peirats-Llobet M, Juan YT, Shen YY, et al. (October 2017).
1954:
van
Faassen EE, Bahrami S, Feelisch M, Hogg N, Kelm M, Kim-Shapiro DB, et al. (September 2009).
1541:
817:
5129:
3739:"Cellular and subcellular localization of endogenous nitric oxide in young and senescent pea plants"
1707:
Hou YC, Janczuk A, Wang PG (June 1999). "Current trends in the development of nitric oxide donors".
1603:
453:
437:
is a mechanism for dynamic, post-translational regulation of most or all major classes of protein.
278:
2687:
Green SJ, Nacy CA, Schreiber RD, Granger DL, Crawford RM, Meltzer MS, Fortier AH (February 1993).
2348:
504:
7324:
7201:
6729:
6461:
6149:
3639:
Gragasin FS, Michelakis ED, Hogan A, Moudgil R, Hashimoto K, Wu X, et al. (September 2004).
2169:"Plant-based Diets | Plant-based Foods | Beetroot Juice | Nitric Oxide Vegetables"
1483:
is cleared from the plasma by the kidney at rates approaching the rate of glomerular filtration.
876:
775:
738:
532:
294:
204:
4178:
Hartman S, Liu Z, van Veen H, Vicente J, Reinen E, Martopawiro S, et al. (September 2019).
7198:
6456:
6159:
5124:
4443:
Melo NK, Bianchetti RE, Lira BS, Oliveira PM, Zuccarelli R, Dias DL, et al. (April 2016).
3291:
Jacobs L, Nawrot TS, de Geus B, Meeusen R, Degraeuwe B, Bernard A, et al. (October 2010).
2471:
1579:
1465:
1411:
1369:
512:
446:
5650:"Nitric oxide inhibits the replication cycle of severe acute respiratory syndrome coronavirus"
5648:
Akerström S, Mousavi-Jazi M, Klingström J, Leijon M, Lundkvist A, Mirazimi A (February 2005).
5571:"Nitric oxide, a 'miracle molecule,' could treat or even prevent coronavirus, top doctors say"
1220:
1145:
558:
and is essential for the regulation of blood flow and blood pressure. NO also plays a role in
495:, raising blood supply and lowering blood pressure. Conversely, it helps protect tissues from
7125:
6622:
6466:
5598:"What Is Nitric Oxide? How the Gas That Gave Us Viagra Could Help Treat Coronavirus Patients"
4610:
3688:
Thakur NK, Hayashi T, Sumi D, Kano H, Matsui-Hirai H, Tsunekawa T, Iguchi A (February 2002).
1029:
326:
145:
4619:
1078:
608:, promotion of the plant hypersensitive response, symbiosis (for example, with organisms in
6471:
6424:
6248:
6174:
6164:
5160:
Ballard RA, Truog WE, Cnaan A, Martin RJ, Ballard PL, Merrill JD, et al. (July 2006).
5027:"The endocannabinoid system: 'NO' longer anonymous in the control of nitrergic signalling?"
4730:
4646:
4558:
4250:
4191:
3851:
3796:
3304:
3056:
3009:
2853:
Seguin MC, Klotz FW, Schneider I, Weir JP, Goodbary M, Slayter M, et al. (July 1994).
1751:
1684:
1619:
1595:
1444:
1360:
Nitric oxide is a potential therapeutic intervention in acute and chronic lung infections.
1098:
993:
389:
83:
63:
are precursors to nitric oxide. Low levels of nitric oxide production are typically due to
4239:"The Cys-Arg/N-End Rule Pathway Is a General Sensor of Abiotic Stress in Flowering Plants"
2234:
Webb AJ, Patel N, Loukogeorgakis S, Okorie M, Aboud Z, Misra S, et al. (March 2008).
321:. Phagocytes are armed with inducible nitric oxide synthase (iNOS), which is activated by
8:
7135:
5708:
2529:
2193:
Ghosh SM, Kapil V, Fuentes-Calvo I, Bubb KJ, Pearl V, Milsom AB, et al. (May 2013).
984:
628:
4650:
4562:
4254:
4195:
3977:
Mur LA, Mandon J, Persijn S, Cristescu SM, Moshkov IE, Novikova GV, et al. (2013).
3855:
3800:
3308:
3060:
3013:
2951:
Klotz FW, Scheller LF, Seguin MC, Kumar N, Marletta MA, Green SJ, Azad AF (April 1995).
1755:
6366:
6323:
5997:
5946:
5902:
5853:
5826:
5478:
5453:
5361:
5227:
5202:
5051:
5026:
5003:
4972:
4929:
4880:
4669:
4634:
4581:
4546:
4471:
4444:
4420:
4395:
4371:
4346:
4322:
4297:
4273:
4238:
4214:
4179:
4152:
4125:
4101:
4074:
4052:
4003:
3978:
3954:
3929:
3877:
3820:
3719:
3670:
3503:
3327:
3292:
3248:
3129:
3104:
2982:
2933:
2879:
2854:
2835:
2444:
2260:
2251:
2235:
2150:
2107:
2029:
1980:
1955:
1668:
1545:
1500:
1380:(cGMP). The elevation of intracellular cGMP results in relaxation by the activation of
850:
616:
601:
and other plants with nitric oxide has been shown to lengthen the time before wilting.
480:
52:
5676:
5649:
5503:"Inhaled nitric oxide as salvage therapy in massive pulmonary embolism: a case series"
5395:
5295:
5278:
3763:
3738:
3536:
Toda N, Ayajiki K, Okamura T (May 2005). "Nitric oxide and penile erectile function".
3450:
3166:
3103:
Li CQ, Pang B, Kiziltepe T, Trudel LJ, Engelward BP, Dedon PC, Wogan GN (March 2006).
2713:
2688:
2211:
2194:
1519:
poisoning, which produces lung tissue-damaging superoxide and hinders NOS metabolism.
1515:. In contrast, inhaled nitric oxide has been shown to help survival and recovery from
341:
in an immune response and is toxic to bacteria and intracellular parasites, including
6343:
6033:
5938:
5894:
5858:
5754:
5681:
5524:
5483:
5434:
5399:
5353:
5300:
5259:
5232:
5183:
5142:
5097:
5056:
5007:
4964:
4933:
4921:
4884:
4872:
4836:
4674:
4586:
4527:
4476:
4425:
4411:
4376:
4327:
4278:
4219:
4157:
4106:
4056:
4044:
4008:
3959:
3913:
3896:
3869:
3812:
3768:
3711:
3706:
3689:
3662:
3621:
3553:
3549:
3495:
3485:
3454:
3418:
3414:
3380:
3355:
3332:
3271:
3240:
3205:
3170:
3134:
3084:
3079:
3044:
3025:
2974:
2925:
2884:
2827:
2791:
2777:
2746:
2718:
2669:
2659:
2636:
2632:
2597:
2436:
2400:
2365:
2306:
2265:
2216:
2142:
2099:
2064:
2021:
1985:
1931:
1908:
1870:
1808:
1787:"Nitric oxide. A novel signal transduction mechanism for transcellular communication"
1767:
1724:
1720:
1672:
1583:
1457:
1373:
1341:
946:
713:
590:
563:
368:
252:
37:
5960:
5950:
5906:
5666:
5365:
4976:
4695:
3897:"Enzymatic sources of nitric oxide in plant cells – beyond one protein–one function"
3881:
3824:
3723:
3674:
3507:
3252:
2986:
2937:
2839:
2448:
2154:
2033:
1904:
1866:
795:
7017:
6611:
6338:
6289:
6169:
5930:
5886:
5848:
5838:
5671:
5661:
5514:
5473:
5465:
5426:
5391:
5345:
5290:
5222:
5218:
5214:
5173:
5134:
5087:
5076:"Cyclic GMP in Vascular Relaxation: Export Is of Similar Importance as Degradation"
5046:
5038:
4999:
4956:
4911:
4864:
4828:
4664:
4654:
4576:
4566:
4517:
4507:
4466:
4456:
4415:
4407:
4366:
4358:
4317:
4309:
4268:
4258:
4209:
4199:
4147:
4137:
4096:
4086:
4036:
3998:
3990:
3949:
3941:
3908:
3859:
3804:
3758:
3750:
3701:
3652:
3611:
3580:
3545:
3477:
3446:
3410:
3322:
3312:
3232:
3197:
3162:
3124:
3116:
3074:
3064:
3043:
Nguyen T, Brunson D, Crespi CL, Penman BW, Wishnok JS, Tannenbaum SR (April 1992).
3017:
2964:
2915:
2874:
2866:
2819:
2781:
2773:
2708:
2700:
2628:
2589:
2428:
2392:
2357:
2326:"Turning DASH Strategy into Reality for Improved Cardio Wellness Outcomes: Part II"
2296:
2255:
2247:
2206:
2134:
2111:
2091:
2056:
2013:
1975:
1967:
1900:
1862:
1798:
1759:
1716:
1181:
1018:
901:
689:
594:
500:
476:
322:
41:
5336:
Griffiths MJ, Evans TW (December 2005). "Inhaled nitric oxide therapy in adults".
3864:
3839:
3616:
3599:
2704:
90:
for elucidating the role of nitric oxide as a cardiovascular signalling molecule.
7298:
7205:
6876:
6664:
6263:
5843:
5430:
5382:
Abrams J (May 1996). "Beneficial actions of nitrates in cardiovascular disease".
4091:
2920:
2903:
2823:
2593:
1656:
1636:
1599:
1537:
1495:
693:
609:
539:
516:
496:
318:
149:
64:
3481:
3472:
Derbyshire ER, Marletta MA (2009). "Biochemistry of Soluble Guanylate Cyclase".
2969:
2952:
153:
is calcium-independent and produces large amounts of gas that can be cytotoxic.
7225:
6884:
6777:
6674:
6374:
6361:
6348:
5994:
5092:
5075:
4639:
Proceedings of the National Academy of Sciences of the United States of America
4551:
Proceedings of the National Academy of Sciences of the United States of America
4204:
3201:
3049:
Proceedings of the National Academy of Sciences of the United States of America
2396:
2172:
2060:
1680:
685:
662:
655:
570:
352:
256:
56:
5890:
5777:"How the gas that gave the world Viagra could help treat coronavirus patients"
4832:
4263:
4180:"Ethylene-mediated nitric oxide depletion pre-adapts plants to hypoxia stress"
4040:
3945:
3808:
3236:
2361:
7308:
7166:
6915:
6724:
6353:
6333:
6328:
6313:
5575:
5544:"Multiple clinical trials test whether NO gas can treat and prevent COVID-19"
4362:
4313:
3584:
1587:
1512:
1340:
and pulmonary toxicities associated with inspired ·NO. Elevated NO may cause
1337:
754:
674:
508:
414:
338:
297:(DNIC), the product from the immune responsive attack of NO on Fe-S proteins.
111:
4659:
4633:
Patel BA, Moreau M, Widom J, Chen H, Yin L, Hua Y, Crane BR (October 2009).
4571:
4545:
Liu WZ, Kong DD, Gu XX, Gao HB, Wang JZ, Xia M, et al. (January 2013).
3994:
3021:
2673:
1803:
1786:
1763:
1503:
when an excessive amount produced during reperfusion (following a period of
7243:
7219:
6550:
6318:
6018:
6005:
5991:
5942:
5898:
5862:
5685:
5528:
5519:
5502:
5487:
5438:
5357:
5304:
5263:
5236:
5187:
5162:"Inhaled nitric oxide in preterm infants undergoing mechanical ventilation"
5146:
5101:
5060:
5011:
4968:
4925:
4876:
4840:
4678:
4590:
4531:
4480:
4429:
4380:
4331:
4282:
4223:
4161:
4110:
4048:
4012:
3963:
3873:
3816:
3772:
3715:
3666:
3625:
3557:
3499:
3458:
3336:
3317:
3244:
3209:
3138:
3069:
2601:
2440:
2404:
2369:
2310:
2269:
2220:
2103:
2068:
2025:
1989:
1912:
1728:
896:
640:
632:
612:
547:
492:
472:
Although NO affects many metalloproteins, it does so by deactivating them.
248:
188:
158:
107:
71:
60:
29:
23:
7249:
cGMP preferring PDE inhibitors (e.g., sildenafil, paraxanthine, tadalafil)
5403:
5042:
4142:
3754:
3657:
3640:
3422:
3174:
3088:
3029:
2978:
2929:
2888:
2870:
2831:
2795:
2750:
2722:
2640:
2432:
2146:
1874:
1812:
1771:
7256:
7027:
6951:
6560:
6555:
6440:
6281:
6179:
6023:
5349:
5178:
5161:
5138:
3979:"Nitric oxide in plants: an assessment of the current state of knowledge"
3573:
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents
3045:"DNA damage and mutation in human cells exposed to nitric oxide in vitro"
2786:
1615:
1492:
1448:
1316:
725:
721:
651:
636:
598:
434:
410:
393:
334:
5730:"Lessons from the Backcountry in Finding a Potential COVID-19 Treatment"
4960:
4522:
4461:
3476:. Handbook of Experimental Pharmacology. Vol. 191. pp. 17–31.
1058:
643:. It plays a role in antioxidant and reactive oxygen species responses.
7229:
7209:
7143:
6797:
6214:
6209:
6098:
6078:
5469:
4898:
Gu Q, Yang X, Lin L, Li S, Li Q, Zhong S, et al. (December 2014).
4393:
3837:
2138:
1508:
1432:
1428:
1196:
1069:
661:
Nitric oxide interactions have been found within signaling pathways of
647:
620:
574:
520:
409:
In cells, two broad classes of reactions of nitric oxide involve the S-
343:
314:
310:
265:
196:
148:(NOSs) synthesize the metastable free radical nitric oxide (NO). Three
139:
131:
127:
79:
75:
5934:
5501:
Summerfield DT, Desai H, Levitov A, Grooms DA, Marik PE (March 2012).
5252:
Journal of the Medical Association of Thailand = Chotmaihet Thangphaet
5203:"Nitric oxide for respiratory failure in infants born at or near term"
4916:
4899:
4868:
4512:
4495:
4494:
Zhang L, Li G, Wang M, Di D, Sun L, Kronzucker HJ, Shi W (July 2018).
4236:
4173:
4171:
4068:
4066:
3120:
2301:
2284:
2017:
1971:
762:
7215:
7174:
7037:
7032:
6093:
5827:"Could nasal nitric oxide help to mitigate the severity of COVID-19?"
5647:
1702:
1700:
1004:
789:
678:
658:
responses such as flooding-induced hypoxia, salt and drought stress.
457:
359:
302:
268:
261:
192:
123:
115:
2616:
2615:
Green SJ, Mellouk S, Hoffman SL, Meltzer MS, Nacy CA (August 1990).
2095:
445:
Nitric oxide to a transition metal ion like iron or copper, forming
231:
prevent food poisoning) and to maintain gastric mucosal blood flow.
7236:
7192:
7178:
7093:
6995:
6684:
6575:
6122:
6013:
5802:"Tufts researchers test inhaled nitric oxide as COVID-19 treatment"
5755:"Inhaled Nitric Oxide Therapy for Emergency Room COVID-19 Patients"
5602:
4168:
4063:
2559:
1956:"Nitrite as regulator of hypoxic signaling in mammalian physiology"
1687:
are mechanisms involved in this protective effect of cannabinoids.
1676:
1664:
1660:
1562:
1516:
1504:
1453:
1431:
and non-healing ulcers, and to be at a greater risk for lower limb
1295:
conjunction with ventilatory support and other appropriate agents.
1125:
1118:
1049:
834:
697:
670:
624:
586:
559:
543:
430:
371:
306:
244:
103:
45:
33:
4547:"Cytokinins can act as suppressors of nitric oxide in Arabidopsis"
2417:
1697:
1219:
461:
440:
7156:
7022:
6535:
6530:
6479:
6298:
6293:
6219:
6139:
6128:
5805:
5249:
4296:
Castillo MC, Costa-Broseta Á, Gayubas B, León J (December 2021).
1591:
1480:
1456:. In the adult ICU setting, inhaled ·NO can improve hypoxemia in
821:
348:
289:
240:
236:
227:
223:
135:
4295:
1742:
Culotta E, Koshland DE (December 1992). "NO news is good news".
404:
7252:
7148:
7042:
6605:
5875:
4072:
3785:
1641:
1156:
597:
and also plays a role in plant pathogen interactions. Treating
397:
385:
374:
195:
contains an ·NO moiety and may act as an NO agonist. Likewise,
48:
5319:"University Studies - Nitric Oxide Holds Promise for Diabetes"
5201:
Barrington KJ, Finer N, Pennaforte T, Altit G (January 2017).
5200:
3638:
1953:
165:
5704:"Applying wisdom from the Himalayas to the ER's COVID battle"
5500:
2808:
2518:
2516:
2233:
1644:
1524:
1447:, either pill or liquid spray forms, which, as a prodrug, is
1210:
1136:
666:
426:
333:(TGF-β) provides a strong inhibitory signal to iNOS, whereas
5114:
3187:
2735:
460:
are deactivated by NO. NO has been demonstrated to activate
7130:
7057:
6631:
5780:
5073:
3736:
2999:
2763:
2192:
1566:
1109:
524:
4853:
4790:"Drug Approval Package: Inomax (Nitric Oxide) NDA# 20-845"
4442:
3435:
3399:
3290:
2614:
2513:
2382:
2125:
Green SJ (June 1995). "Nitric oxide in mucosal immunity".
2002:
1851:
5919:
4177:
4123:
3976:
3152:
3042:
2686:
433:
residues in proteins, to form S-nitrosothiols (RSNOs). S-
5074:
Krawutschke C, Koesling D, Russwurm M (September 2015).
3474:
CGMP: Generators, Effectors and Therapeutic Implications
2950:
2852:
2467:"'Nose breathing has more benefits than mouth breathing"
2081:
692:, and can have effects ranging from leaf blemishing, to
5416:
5377:
5375:
5159:
2901:
1582:
N. Stuart Harris, who has been studying the effects of
523:(Viagra) works to inhibit the enzyme phosphodiesterase
6014:
Nitroxyl anion (NO; oxonitrate(1-), hyponitrite anion)
4690:
4688:
3268:
Immunobiology: the immune system in health and disease
2902:
Mellouk S, Green SJ, Nacy CA, Hoffman SL (June 1991).
2046:
425:
S-nitrosation involves the (reversible) conversion of
134:
as a byproduct. NO production by eNOS is dependent on
7282:
5990:
5445:
5276:
4770:. U.S. National Library of Medicine. 25 February 2019
3687:
3102:
2525:"Could nasal breathing improve athletic performance?"
483:
and leading to relaxation of the smooth muscle cell.
329:(TNF) along with a second signal. On the other hand,
5451:
5372:
4818:
4632:
3894:
3352:
Radicals for life: The various forms of nitric oxide
2555:"Undiagnosed Mouth Breathing Creates Unhealthy Kids"
1928:
Radicals for life: The various forms of nitric oxide
6505:
Methylamine hexamethylene methylamine/NO (MAHMA/NO)
5825:Martel J, Ko YF, Young JD, Ojcius DM (2020-05-06).
5824:
4758:
4756:
4685:
4025:
3222:
3155:
Biochemical and Biophysical Research Communications
2345:
2285:"The oral microbiome and nitric oxide homoeostasis"
1037:
173:
5277:Hayward CS, Kelly RP, Macdonald PS (August 1999).
5080:Arteriosclerosis, Thrombosis, and Vascular Biology
3535:
3471:
646:Nitric oxide sensing in plants is mediated by the
589:in plants is debated), (ii) plasma membrane-bound
486:
6319:Amyl nitrite (isoamyl nitrite, isopentyl nitrite)
5624:"Nitric Oxide Investigated as COVID-19 Treatment"
4124:León J, Costa-Broseta Á, Castillo MC (May 2020).
2653:
2497:"'Mouth-breathing' gross, harmful to your health"
1949:
1947:
627:opening. Nitric oxide is known to be produced by
86:" in 1992. Research into its function led to the
51:. In mammals including humans, nitric oxide is a
7306:
5410:
4753:
4616:National Council for Science and the Environment
3598:Yoon Y, Song J, Hong SH, Kim JQ (October 2000).
3374:
3349:
1925:
1017:
6180:Naproxcinod (nitronaproxen; AZD-3582, HCT-3012)
3597:
3375:van Faassen E, Vanin A (2004). "Nitric Oxide".
2548:
2546:
1741:
992:
441:Nitrosylation of metal centers, especially iron
5452:Andersson MC, Tobin G, Giglio D (April 2008).
5335:
4725:
4723:
4721:
4719:
4717:
3265:
2579:
2282:
1944:
1706:
1586:on mountain climbers, such as those who climb
1427:diabetic patient to be more likely to develop
531:concentration by inhibiting the conversion to
122:(eNOS). eNOS synthesizes NO from the terminal
6596:N-Acetyl-N-acetoxy-4-chlorobenzenesulfonamide
6155:Ethylene glycol dinitrate (EGDN; nitroglycol)
5976:
5279:"Inhaled nitric oxide in cardiology practice"
4989:
4493:
3520:
1671:(I/R), thereby protecting cardiac cells from
1390:Inhaled nitric oxide appears to increase the
724:). These insects deliver NO from its carrier
405:Molecular effects of NO on biological systems
5757:. Massachusetts General Hospital. 2020-06-24
5494:
5153:
5108:
5024:
4544:
4387:
4019:
3930:"Max-Planck Society investigates misconduct"
3216:
3181:
2543:
2339:
838:
281:also produces nitric oxide within the body.
98:
5207:The Cochrane Database of Systematic Reviews
4897:
4714:
3270:(6th ed.). New York: Garland Science.
951:In general: ℞ (Prescription only)
384:(meter of inflammation) in conditions like
217:
5983:
5969:
5697:
5695:
5541:
3895:Corpas FJ, Barroso JB, Del Río LA (2004).
3570:
2490:
2488:
1845:
1778:
1735:
1614:It is found, that the naturally occurring
1438:
1077:
420:
93:
6339:Isobutyl nitrite (2-methylpropyl nitrite)
6249:Nitroglycerin (glyceryl trinitrate (GTN))
5852:
5842:
5818:
5675:
5665:
5518:
5477:
5294:
5226:
5177:
5128:
5091:
5050:
4915:
4668:
4658:
4580:
4570:
4521:
4511:
4470:
4460:
4419:
4370:
4321:
4272:
4262:
4213:
4203:
4151:
4141:
4100:
4090:
4002:
3953:
3912:
3863:
3762:
3705:
3656:
3615:
3529:
3326:
3316:
3128:
3078:
3068:
2968:
2919:
2878:
2785:
2712:
2300:
2259:
2210:
1979:
1824:
1822:
1802:
1598:. Other studies speculate that replacing
1097:
5923:Diabetes/Metabolism Research and Reviews
5774:
5722:
5535:
1594:, similar trials are being conducted at
413:of thiols and the nitrosylation of some
288:
164:
6415:S-Nitrosocysteine (SNC, CysNO, SNO-Cys)
6405:S-Nitroso-N-valerylpenicillamine (SNVP)
5793:
5692:
4344:
2552:
2485:
2464:
2460:
2458:
1831:"Could the sun be good for your heart?"
1784:
1376:and increasing intracellular levels of
1057:
684:Atmospheric nitric oxide can enter the
388:, interest has increased in the use of
7307:
6400:S-Nitroso-N-acetylpenicillamine (SNAP)
6274:Sodium trioxodinitrate (Angeli's salt)
5799:
5701:
5595:
5381:
5323:National Federation of the Blind (NFB)
3694:Journal of Cardiovascular Pharmacology
3284:
2522:
2421:Clinical Pharmacology and Therapeutics
2283:Hezel MP, Weitzberg E (January 2015).
1890:
1828:
1819:
1363:
1347:
1331:
1309:
812:
731:
70:As a consequence of its importance in
16:Functions of nitric oxide in organisms
5964:
5768:
5568:
4608:. In Monosson E, Cleveland C (eds.).
4603:
3927:
2323:
2124:
1926:van Faassen E, Vanin A, eds. (2007).
1886:
1884:
1609:
1536:Nitric oxide is also administered as
1531:
1164:
1144:
940:
829:
794:
703:
7235:non-selective PDE inhibitors (e.g.,
6019:Nitric oxide (NO; nitrogen monoxide)
4946:
4821:Veterinary Anaesthesia and Analgesia
3266:Janeway, C. A.; et al. (2005).
2859:The Journal of Experimental Medicine
2494:
2455:
1569:. Brian Strickland, MD, a fellow in
1378:cyclic-guanosine 3',5'-monophosphate
1322:
900:
580:
467:
199:, popularly known by the trade name
20:Biological functions of nitric oxide
6259:Pentaerithrityl tetranitrate (PETN)
6145:Diethylene glycol dinitrate (DEGDN)
5879:Molecular and Cellular Biochemistry
5747:
5338:The New England Journal of Medicine
5166:The New England Journal of Medicine
5117:The New England Journal of Medicine
4696:"Nitric oxide Use During Pregnancy"
1655:dependent manner, while increasing
1647:cells through the induction of the
1471:
1462:acute respiratory distress syndrome
1416:extracorporeal membrane oxygenation
1392:partial pressure of arterial oxygen
1284:extracorporeal membrane oxygenation
1124:
1117:
1008:
365:specialized pro-resolving mediators
207:(DNIC), and even nitrite anions (NO
13:
7164:Indirect/downstream NO modulators:
6932:Asymmetric dimethylarginine (ADMA)
6041:
5589:
5562:
5384:The American Journal of Cardiology
5025:Lipina C, Hundal HS (April 2017).
5004:10.1097/01.CCM.0000251290.41866.2B
3377:Encyclopedia of Analytical Science
2252:10.1161/HYPERTENSIONAHA.107.103523
1881:
1855:The American Journal of Physiology
1443:The primary use is in the form of
728:, which is found in their saliva.
604:In plants, NO also regulates some
284:
118:stimulate the production of NO by
14:
7336:
6962:Nitroarginine methyl ester (NAME)
6425:S-Nitrosoglutathione (GSNO, SNOG)
6395:S-Nitroso-N-acetylcysteine (SNAC)
6269:Propylene glycol dinitrate (PGDN)
6024:Nitrosonium (NO; nitrosyl cation)
5031:Journal of Molecular Cell Biology
2658:. Austin, TX: Landes Bioscience.
2654:Gorczynski RM, Stanley J (1999).
2212:10.1161/HYPERTENSIONAHA.111.00933
1893:Journal of Inorganic Biochemistry
1657:endothelial nitric oxide synthase
1355:
927:
861:
550:often show impaired NO pathways.
325:(IFN-γ) as a single signal or by
120:endothelial nitric oxide synthase
7292:
5913:
5869:
5419:European Journal of Pharmacology
4412:10.1111/j.1365-313X.2011.04885.x
3914:10.1111/j.1469-8137.2004.01058.x
3707:10.1097/00005344-200202000-00017
3550:10.1016/j.pharmthera.2004.11.011
1721:10.2174/138161280506230110111042
1511:to produce the damaging oxidant
1186:
761:
174:Exogenous NO (NO-delivery drugs)
6490:Diethylenetriamine/NO (DETA/NO)
5667:10.1128/JVI.79.3.1966-1969.2005
5641:
5616:
5549:Chemical & Engineering News
5458:British Journal of Pharmacology
5329:
5311:
5270:
5243:
5194:
5067:
5018:
4983:
4940:
4891:
4847:
4812:
4782:
4626:
4597:
4538:
4487:
4436:
4338:
4289:
4230:
4117:
3970:
3921:
3888:
3831:
3779:
3730:
3681:
3632:
3591:
3564:
3538:Pharmacology & Therapeutics
3514:
3465:
3429:
3393:
3368:
3350:van Faassen E, Vanin A (2007).
3343:
3259:
3146:
3109:Chemical Research in Toxicology
3096:
3036:
2993:
2944:
2895:
2846:
2802:
2757:
2729:
2680:
2647:
2608:
2573:
2411:
2376:
2317:
2276:
2227:
2186:
2171:. Berkeley Test. Archived from
2161:
2118:
2075:
2040:
1905:10.1016/j.jinorgbio.2004.10.009
1867:10.1152/ajpregu.1997.273.2.R823
1649:inducible nitric oxide synthase
1486:
1405:
1267:Key:MWUXSHHQAYIFBG-UHFFFAOYSA-N
746:
556:extracellular fluid homeostasis
487:Vasodilation and smooth muscles
331:transforming growth factor-beta
82:, nitric oxide was proclaimed "
6690:N-(1-Iminoethyl)-L-ornithine (
5734:Massachusetts General Hospital
5219:10.1002/14651858.CD000399.pub3
4130:Journal of Experimental Botany
3840:"Nitrosative stress in plants"
3521:Rhoades RA, Tanner GA (2003).
2084:Nature Reviews. Drug Discovery
1996:
1919:
1575:Massachusetts General Hospital
1491:Nitric oxide is considered an
1189:
615:), development of lateral and
573:to decrease contractility and
497:damage due to low blood supply
1:
7273:Receptor/signaling modulators
6942:Guanidinoethyldisulfide (GED)
6160:Isosorbide mononitrate (ISMN)
6150:Erythritol tetranitrate (ETN)
5396:10.1016/S0002-9149(96)00186-5
5296:10.1016/S0008-6363(99)00114-5
3865:10.1016/j.febslet.2007.01.006
3451:10.1016/S0168-8278(99)80270-0
3167:10.1016/S0006-291X(88)80015-9
2705:10.1128/IAI.61.2.689-698.1993
2582:Accounts of Chemical Research
1709:Current Pharmaceutical Design
1690:
1382:cGMP-dependent protein kinase
452:The iron-containing proteins
301:Nitric oxide is generated by
6410:S-Nitrosocaptopril (SNO-Cap)
6239:Nitroflurbiprofen (HCT-1026)
6234:Nitroatorvastatin (NCX-6560)
5844:10.1016/j.micinf.2020.05.002
5431:10.1016/j.ejphar.2011.11.020
4949:Nature Reviews. Microbiology
4796:Food and Drug Administration
4092:10.1016/j.molcel.2013.12.020
3415:10.1016/0145-2126(95)00013-E
2921:10.4049/jimmunol.146.11.3971
2824:10.4049/jimmunol.145.12.4290
2778:10.1016/0165-2478(94)00158-8
2633:10.1016/0165-2478(90)90083-3
2594:10.1021/acs.accounts.5b00246
2349:Current Hypertension Reports
1797:(5). Dallas, Texas: 477–83.
1785:Ignarro LJ (November 1990).
1640:, increase NO production in
1620:delta-9-tetrahydrocannabinol
1421:
211:) under hypoxic conditions
7:
7315:Gaseous signaling molecules
6885:Aminoguanidine (pimagedine)
6778:Aminoguanidine (pimagedine)
6675:Aminoguanidine (pimagedine)
6439:N-Nitroso compounds (e.g.,
6254:Nitropravastatin (NCX-6550)
6165:Isosorbide dinitrate (ISDN)
5542:Katsnelson A (2020-05-20).
4345:Hartman S (December 2021).
3617:10.1093/clinchem/46.10.1626
3482:10.1007/978-3-540-68964-5_2
2970:10.4049/jimmunol.154.7.3391
1556:
1551:
503:, nitric oxide acts in the
10:
7341:
7171:AT-II receptor antagonists
6916:Nitroarginine (NNA, NOARG)
6753:1-Amino-2-hydroxyguanidine
6725:Nitroarginine (NNA, NOARG)
6472:Sodium nitroprusside (SNP)
5093:10.1161/ATVBAHA.115.306133
4764:"Inomax- nitric oxide gas"
4205:10.1038/s41467-019-12045-4
3379:(2nd ed.). Elsevier.
3202:10.1016/j.smim.2015.05.004
2397:10.1016/j.niox.2009.10.006
2061:10.1016/j.niox.2013.10.001
1960:Medicinal Research Reviews
1602:(which decimates NO) with
1176:Chemical and physical data
606:plant-pathogen interaction
569:Nitric oxide also acts on
7266:
7083:
7056:
6994:
6924:
6875:
6743:
6630:
6621:
6604:
6121:
6032:
6004:
5891:10.1007/s11010-006-2346-y
5775:Meredith S (2020-05-01).
4857:Equine Veterinary Journal
4833:10.1016/j.vaa.2016.11.015
4736:European Medicines Agency
4264:10.1016/j.cub.2017.09.006
4041:10.1007/s10534-013-9608-4
3946:10.1136/bmj.319.7205.274a
3809:10.1007/s00425-005-0205-9
3237:10.1007/s00011-015-0857-2
2362:10.1007/s11906-017-0725-2
1829:Weller R (January 2013).
1542:right ventricular failure
1290:function and oxygenation.
1250:
1230:
1208:
1195:
1180:
1175:
1155:
1135:
1108:
1088:
1068:
1048:
1028:
1003:
983:
963:
958:
917:
912:
887:
875:
849:
802:
784:
780:Inomax, Noxivent, Genosyl
774:
769:
760:
205:dinitrosyl iron complexes
99:Nitric oxide biosynthesis
32:(nitrogen monoxide) is a
6650:3-Chloro-5-nitroindazole
6485:Diethylamine/NO (DEA/NO)
6457:Metal nitrosyl complexes
6385:S-Nitrosoalbumin (SNALB)
6079:Cinaciguat (BAY 58-2667)
3585:10.2174/1568014043355348
2553:Vinopal L (2019-07-19).
2465:Glazier E (2019-11-04).
2328:. Real World Health Care
1675:damage, probably by pre-
454:ribonucleotide reductase
447:metal nitrosyl complexes
218:Other, including dietary
7242:PDE9 inhibitors (e.g.,
6730:Pentamidine isethionate
6640:3-Bromo-7-nitroindazole
6527:Heterocyclic compounds:
6051:Activators/stimulators:
5800:Riemer E (2020-06-23).
5702:Powell A (2020-05-06).
5596:Gander K (2020-04-07).
5283:Cardiovascular Research
4660:10.1073/pnas.0907262106
4572:10.1073/pnas.1213235110
3354:. Amsterdam: Elsevier.
3022:10.1126/science.1948068
2739:Journal of Inflammation
2523:Berman J (2019-01-29).
2324:Green SJ (2013-07-25).
1930:. Amsterdam: Elsevier.
1804:10.1161/01.hyp.16.5.477
1764:10.1126/science.1361684
1540:in patients with acute
1439:Pediatric and adult use
739:Deinococcus radiodurans
421:S-nitrosation of thiols
317:) as part of the human
295:dinitrosyl iron complex
94:Sources of nitric oxide
7199:L-Type calcium channel
5831:Microbes and Infection
5569:Cohan A (2020-07-26).
5520:10.4187/respcare.01373
4992:Critical Care Medicine
4363:10.1093/plphys/kiab415
4314:10.1093/plphys/kiab382
3318:10.1186/1476-069X-9-64
3190:Seminars in Immunology
3070:10.1073/pnas.89.7.3030
2693:Infection and Immunity
2472:The Times and Democrat
1580:Harvard Medical School
1466:pulmonary hypertension
1412:pulmonary hypertension
1370:endocannabinoid system
527:, which increases the
513:gastrointestinal tract
298:
170:
146:Nitric oxide synthases
130:and oxygen and yields
26:plays within biology.
6803:Cindunistat (SD-6010)
6758:2-Ethylaminoguanidine
6515:Spermine/NO (SPER/NO)
6312:O-Nitroso compounds (
4611:Encyclopedia of Earth
4184:Nature Communications
3995:10.1093/aobpla/pls052
3928:Tuffs A (July 1999).
3755:10.1104/pp.104.042812
3658:10.1096/fj.04-1978com
3439:Journal of Hepatology
3225:Inflammation Research
2957:Journal of Immunology
2908:Journal of Immunology
2871:10.1084/jem.180.1.353
2812:Journal of Immunology
2495:Dahl M (2011-01-11).
2433:10.1038/clpt.2011.366
1861:(2 Pt 2): R823–R827.
1659:(eNOS) expression in
1651:(iNOS) activity in a
560:erection of the penis
493:dilates blood vessels
327:tumor necrosis factor
292:
168:
142:and other cofactors.
7189:receptor antagonists
6862:Ronopterin (VAS-203)
6561:Molsidomine (SIN-10)
6482:(diazeniumdiolates):
6462:Roussin's black salt
6175:Mannitol hexanitrate
5350:10.1056/NEJMra051884
5179:10.1056/NEJMoa061088
5139:10.1056/NEJMoa060442
4249:(20): 3183–3190.e4.
3297:Environmental Health
1596:Tufts Medical Center
390:exhaled nitric oxide
84:Molecule of the Year
6556:Linsidomine (SIN-1)
6453:Nitrosyl compounds:
6420:S-Nitrosodiclofenac
6390:S-Nitrosated AR545C
6375:S-Nitroso compounds
5709:The Harvard Gazette
5654:Journal of Virology
5043:10.1093/jmcb/mjx008
4961:10.1038/nrmicro1004
4740:. 17 September 2018
4651:2009PNAS..10618183P
4645:(43): 18183–18188.
4563:2013PNAS..110.1548L
4500:The New Phytologist
4462:10.1104/pp.16.00023
4255:2017CBio...27E3183V
4196:2019NatCo..10.4020H
4143:10.1093/jxb/eraa069
3856:2007FEBSL.581..453V
3801:2006Plant.224..246C
3309:2010EnvHe...9...64J
3061:1992PNAS...89.3030N
3014:1991Sci...254.1001W
3008:(5034): 1001–1003.
2656:Clinical Immunology
2530:The Washington Post
1756:1992Sci...258.1862C
1750:(5090): 1862–1865.
1571:Wilderness Medicine
1364:Mechanism of action
1348:Fatty liver disease
1332:Dosage and strength
1310:Associated problems
936:(Prescription only)
757:
732:Effects in bacteria
629:cellular organelles
7320:Nitrogen compounds
6467:Roussin's red salt
6324:Cyclohexyl nitrite
6215:Nipradilol (K-351)
5470:10.1038/bjp.2008.6
4702:. 21 November 2019
3604:Clinical Chemistry
3523:Medical physiology
2766:Immunology Letters
2621:Immunology Letters
2139:10.1038/nm0695-515
2006:Blood Purification
1663:hearts subject to
1610:Cardiac protection
1546:pulmonary embolism
1532:Pulmonary embolism
1501:reperfusion injury
753:
718:Rhodnius proxlixus
704:Effects in insects
694:stunting of growth
617:adventitious roots
511:, abundant in the
481:cross-bridge cycle
429:groups, including
299:
197:Sildenafil citrate
171:
106:-derived factors,
53:signaling molecule
7280:
7279:
7105:
7096:
7079:
7078:
7012:
6990:
6989:
6910:
6906:
6897:
6893:
6890:N-(1-Iminoethyl)-
6856:
6852:
6843:
6839:
6836:N-(1-Iminoethyl)-
6830:
6826:
6823:N-(1-Iminoethyl)-
6763:2-Iminopiperidine
6719:
6715:
6706:
6702:
6693:
6615:
6344:Isopropyl nitrite
6290:Nitroso compounds
6132:
6117:
6116:
5935:10.1002/dmrr.1176
5344:(25): 2683–2695.
4917:10.1002/hep.27356
4869:10.1111/evj.13129
4614:. Washington DC:
4604:Hogan CM (2010).
4513:10.1111/nph.15157
4400:The Plant Journal
4136:(10): 3157–3171.
3651:(12): 1382–1391.
3610:(10): 1626–1630.
3491:978-3-540-68960-7
3403:Leukemia Research
3386:978-0-12-764100-3
3361:978-0-444-52236-8
3277:978-0-8153-4101-7
3121:10.1021/tx050283e
2914:(11): 3971–3976.
2818:(12): 4290–4297.
2665:978-1-57059-625-4
2302:10.1111/odi.12157
2018:10.1159/000063555
1972:10.1002/med.20151
1937:978-0-444-52236-8
1584:altitude sickness
1458:acute lung injury
1374:guanylate cyclase
1342:acute lung injury
1323:Contraindications
1275:
1274:
1221:Interactive image
944:
931:
865:
832:
815:
710:Cimex lectularius
623:, and control of
591:nitrate reductase
581:Effects on plants
505:nitrergic neurons
468:Guanylate cyclase
396:in diseases with
253:nitrate reductase
38:chemical compound
7332:
7297:
7296:
7295:
7288:
7206:dihydropyridines
7106:-arginine (NOHA)
7103:
7094:
7048:alpha aminoacids
7018:chlorogenic acid
7013:-arginine (NOHA)
7010:
6908:
6904:
6895:
6891:
6854:
6850:
6841:
6837:
6828:
6824:
6717:
6713:
6704:
6700:
6691:
6645:3-Chloroindazole
6628:
6627:
6619:
6618:
6609:
6307:
6306:
6244:Nitrofluvastatin
6228:
6227:
6170:Itramin tosilate
6126:
6039:
6038:
5985:
5978:
5971:
5962:
5961:
5955:
5954:
5917:
5911:
5910:
5873:
5867:
5866:
5856:
5846:
5837:(4–5): 168–171.
5822:
5816:
5815:
5813:
5812:
5797:
5791:
5790:
5788:
5787:
5772:
5766:
5765:
5763:
5762:
5751:
5745:
5744:
5742:
5741:
5726:
5720:
5719:
5717:
5716:
5699:
5690:
5689:
5679:
5669:
5660:(3): 1966–1969.
5645:
5639:
5638:
5636:
5634:
5620:
5614:
5613:
5611:
5610:
5593:
5587:
5586:
5584:
5583:
5566:
5560:
5559:
5557:
5556:
5539:
5533:
5532:
5522:
5507:Respiratory Care
5498:
5492:
5491:
5481:
5464:(7): 1438–1444.
5449:
5443:
5442:
5425:(2–3): 445–449.
5414:
5408:
5407:
5379:
5370:
5369:
5333:
5327:
5326:
5315:
5309:
5308:
5298:
5274:
5268:
5267:
5247:
5241:
5240:
5230:
5198:
5192:
5191:
5181:
5157:
5151:
5150:
5132:
5112:
5106:
5105:
5095:
5086:(9): 2011–2019.
5071:
5065:
5064:
5054:
5022:
5016:
5015:
4987:
4981:
4980:
4944:
4938:
4937:
4919:
4910:(6): 1929–1941.
4895:
4889:
4888:
4851:
4845:
4844:
4827:(5): 1139–1148.
4816:
4810:
4809:
4807:
4805:
4786:
4780:
4779:
4777:
4775:
4760:
4751:
4749:
4747:
4745:
4727:
4712:
4711:
4709:
4707:
4692:
4683:
4682:
4672:
4662:
4630:
4624:
4623:
4622:on June 8, 2013.
4618:. Archived from
4606:"Abiotic factor"
4601:
4595:
4594:
4584:
4574:
4557:(4): 1548–1553.
4542:
4536:
4535:
4525:
4515:
4491:
4485:
4484:
4474:
4464:
4455:(4): 2278–2294.
4449:Plant Physiology
4440:
4434:
4433:
4423:
4391:
4385:
4384:
4374:
4357:(4): 2346–2347.
4351:Plant Physiology
4342:
4336:
4335:
4325:
4308:(4): 2731–2748.
4302:Plant Physiology
4293:
4287:
4286:
4276:
4266:
4234:
4228:
4227:
4217:
4207:
4175:
4166:
4165:
4155:
4145:
4121:
4115:
4114:
4104:
4094:
4070:
4061:
4060:
4023:
4017:
4016:
4006:
3974:
3968:
3967:
3957:
3925:
3919:
3918:
3916:
3892:
3886:
3885:
3867:
3835:
3829:
3828:
3783:
3777:
3776:
3766:
3749:(1): 2722–2733.
3743:Plant Physiology
3734:
3728:
3727:
3709:
3685:
3679:
3678:
3660:
3636:
3630:
3629:
3619:
3595:
3589:
3588:
3568:
3562:
3561:
3533:
3527:
3526:
3518:
3512:
3511:
3469:
3463:
3462:
3445:(6): 1138–1145.
3433:
3427:
3426:
3397:
3391:
3390:
3372:
3366:
3365:
3347:
3341:
3340:
3330:
3320:
3288:
3282:
3281:
3263:
3257:
3256:
3220:
3214:
3213:
3185:
3179:
3178:
3150:
3144:
3142:
3132:
3100:
3094:
3092:
3082:
3072:
3055:(7): 3030–3034.
3040:
3034:
3033:
2997:
2991:
2990:
2972:
2963:(7): 3391–3395.
2948:
2942:
2941:
2923:
2899:
2893:
2892:
2882:
2850:
2844:
2843:
2806:
2800:
2799:
2789:
2761:
2755:
2754:
2733:
2727:
2726:
2716:
2684:
2678:
2677:
2651:
2645:
2644:
2612:
2606:
2605:
2588:(8): 2453–2461.
2577:
2571:
2570:
2568:
2567:
2550:
2541:
2540:
2538:
2537:
2520:
2511:
2510:
2508:
2507:
2492:
2483:
2482:
2480:
2479:
2462:
2453:
2452:
2427:(6): 1074–1082.
2415:
2409:
2408:
2380:
2374:
2373:
2343:
2337:
2336:
2334:
2333:
2321:
2315:
2314:
2304:
2280:
2274:
2273:
2263:
2231:
2225:
2224:
2214:
2205:(5): 1091–1102.
2190:
2184:
2183:
2181:
2180:
2165:
2159:
2158:
2122:
2116:
2115:
2079:
2073:
2072:
2044:
2038:
2037:
2000:
1994:
1993:
1983:
1951:
1942:
1941:
1923:
1917:
1916:
1888:
1879:
1878:
1849:
1843:
1842:
1837:. Archived from
1826:
1817:
1816:
1806:
1782:
1776:
1775:
1739:
1733:
1732:
1704:
1634:), appearing in
1472:Pharmacokinetics
1262:InChI=1S/NO/c1-2
1223:
1203:
1191:
1188:
1168:
1148:
1128:
1121:
1101:
1081:
1061:
1041:
1021:
1011:
1010:
996:
942:
939:
929:
926:
904:
863:
860:
842:
831:
828:
825:
814:
811:
798:
765:
758:
756:
752:
690:vascular species
595:oxidative stress
501:neurotransmitter
477:protein kinase G
323:interferon-gamma
88:1998 Nobel Prize
42:chemical formula
7340:
7339:
7335:
7334:
7333:
7331:
7330:
7329:
7305:
7304:
7303:
7293:
7291:
7283:
7281:
7276:
7262:
7226:PDE5 inhibitors
7188:
7152:
7139:
7075:
7052:
6986:
6920:
6871:
6739:
6665:7-Nitroindazole
6660:6-Nitroindazole
6655:5-Nitroindazole
6608:
6600:
6377:(thionitrites):
6305:
6302:
6301:
6300:
6264:Propatylnitrate
6226:
6223:
6222:
6221:
6125:
6113:
6028:
6000:
5989:
5959:
5958:
5918:
5914:
5874:
5870:
5823:
5819:
5810:
5808:
5798:
5794:
5785:
5783:
5773:
5769:
5760:
5758:
5753:
5752:
5748:
5739:
5737:
5728:
5727:
5723:
5714:
5712:
5700:
5693:
5646:
5642:
5632:
5630:
5622:
5621:
5617:
5608:
5606:
5594:
5590:
5581:
5579:
5567:
5563:
5554:
5552:
5540:
5536:
5499:
5495:
5450:
5446:
5415:
5411:
5390:(13): 31C–37C.
5380:
5373:
5334:
5330:
5317:
5316:
5312:
5275:
5271:
5248:
5244:
5213:(1): CD000399.
5199:
5195:
5158:
5154:
5130:10.1.1.319.6088
5113:
5109:
5072:
5068:
5023:
5019:
4988:
4984:
4955:(10): 820–832.
4945:
4941:
4896:
4892:
4852:
4848:
4817:
4813:
4803:
4801:
4800:. 31 March 2001
4788:
4787:
4783:
4773:
4771:
4762:
4761:
4754:
4743:
4741:
4729:
4728:
4715:
4705:
4703:
4694:
4693:
4686:
4631:
4627:
4602:
4598:
4543:
4539:
4492:
4488:
4441:
4437:
4392:
4388:
4343:
4339:
4294:
4290:
4243:Current Biology
4235:
4231:
4176:
4169:
4122:
4118:
4071:
4064:
4024:
4020:
3975:
3971:
3926:
3922:
3901:New Phytologist
3893:
3889:
3836:
3832:
3784:
3780:
3735:
3731:
3686:
3682:
3637:
3633:
3596:
3592:
3569:
3565:
3534:
3530:
3525:(2nd ed.).
3519:
3515:
3492:
3470:
3466:
3434:
3430:
3398:
3394:
3387:
3373:
3369:
3362:
3348:
3344:
3289:
3285:
3278:
3264:
3260:
3231:(11): 845–852.
3221:
3217:
3186:
3182:
3151:
3147:
3101:
3097:
3041:
3037:
2998:
2994:
2949:
2945:
2900:
2896:
2851:
2847:
2807:
2803:
2762:
2758:
2734:
2730:
2685:
2681:
2666:
2652:
2648:
2613:
2609:
2578:
2574:
2565:
2563:
2551:
2544:
2535:
2533:
2521:
2514:
2505:
2503:
2493:
2486:
2477:
2475:
2463:
2456:
2416:
2412:
2381:
2377:
2344:
2340:
2331:
2329:
2322:
2318:
2281:
2277:
2232:
2228:
2191:
2187:
2178:
2176:
2167:
2166:
2162:
2127:Nature Medicine
2123:
2119:
2096:10.1038/nrd2466
2080:
2076:
2045:
2041:
2001:
1997:
1952:
1945:
1938:
1924:
1920:
1889:
1882:
1850:
1846:
1827:
1820:
1783:
1779:
1740:
1736:
1705:
1698:
1693:
1633:
1629:
1625:
1612:
1604:nasal breathing
1600:mouth breathing
1559:
1554:
1538:salvage therapy
1534:
1489:
1474:
1441:
1424:
1408:
1401:
1397:
1366:
1358:
1350:
1334:
1325:
1312:
1271:
1268:
1263:
1258:
1257:
1246:
1243:
1238:
1237:
1226:
1201:
1171:
1151:
1131:
1104:
1084:
1064:
1044:
1024:
1007:
999:
979:
976:
971:
970:
954:
908:
878:
871:
852:
845:
749:
734:
706:
610:nitrogen-fixing
583:
540:atherosclerosis
517:erectile tissue
489:
470:
443:
423:
407:
319:immune response
287:
285:Immune response
279:Nasal breathing
220:
210:
176:
101:
96:
65:ischemic damage
22:are roles that
17:
12:
11:
5:
7338:
7328:
7327:
7325:Nitrogen cycle
7322:
7317:
7302:
7301:
7278:
7277:
7267:
7264:
7263:
7261:
7260:
7250:
7247:
7240:
7233:
7223:
7213:
7196:
7186:
7182:
7167:ACE inhibitors
7160:
7159:
7154:
7150:
7146:
7141:
7137:
7133:
7128:
7123:
7118:
7109:
7108:
7099:
7087:
7085:
7081:
7080:
7077:
7076:
7074:
7073:
7068:
7062:
7060:
7054:
7053:
7051:
7050:
7045:
7040:
7035:
7030:
7025:
7020:
7015:
7006:
7000:
6998:
6992:
6991:
6988:
6987:
6985:
6984:
6979:
6974:
6969:
6964:
6959:
6954:
6949:
6944:
6939:
6934:
6928:
6926:
6922:
6921:
6919:
6918:
6913:
6900:
6887:
6881:
6879:
6873:
6872:
6870:
6869:
6864:
6859:
6846:
6833:
6820:
6815:
6810:
6805:
6800:
6795:
6790:
6785:
6780:
6775:
6770:
6765:
6760:
6755:
6749:
6747:
6741:
6740:
6738:
6737:
6732:
6727:
6722:
6709:
6696:
6687:
6682:
6677:
6672:
6667:
6662:
6657:
6652:
6647:
6642:
6636:
6634:
6625:
6616:
6602:
6601:
6599:
6598:
6593:
6588:
6583:
6578:
6569:
6568:
6563:
6558:
6553:
6538:
6523:
6522:
6517:
6512:
6507:
6502:
6497:
6492:
6487:
6475:
6474:
6469:
6464:
6449:
6448:
6432:
6427:
6422:
6417:
6412:
6407:
6402:
6397:
6392:
6387:
6382:
6370:-Butyl nitrite
6364:
6362:Pentyl nitrite
6359:
6357:-Butyl nitrite
6351:
6349:Methyl nitrite
6346:
6341:
6336:
6331:
6326:
6321:
6314:alkyl nitrites
6303:
6285:
6284:
6279:
6276:
6271:
6266:
6261:
6256:
6251:
6246:
6241:
6236:
6231:
6224:
6217:
6212:
6207:
6202:
6197:
6192:
6187:
6182:
6177:
6172:
6167:
6162:
6157:
6152:
6147:
6135:
6133:
6119:
6118:
6115:
6114:
6112:
6111:
6102:
6101:
6096:
6091:
6086:
6081:
6076:
6071:
6066:
6061:
6056:
6047:
6045:
6036:
6030:
6029:
6027:
6026:
6021:
6016:
6010:
6008:
6002:
6001:
5988:
5987:
5980:
5973:
5965:
5957:
5956:
5929:(4): 331–340.
5912:
5885:(1–2): 75–83.
5868:
5817:
5792:
5767:
5746:
5721:
5691:
5640:
5615:
5588:
5561:
5534:
5513:(3): 444–448.
5493:
5444:
5409:
5371:
5328:
5310:
5289:(3): 628–638.
5269:
5258:(2): 266–271.
5242:
5193:
5172:(4): 343–353.
5152:
5123:(4): 354–364.
5107:
5066:
5017:
4998:(1): 290–292.
4982:
4939:
4890:
4846:
4811:
4781:
4752:
4713:
4684:
4625:
4596:
4537:
4506:(1): 259–274.
4486:
4435:
4406:(3): 492–500.
4386:
4337:
4288:
4229:
4167:
4116:
4085:(3): 369–379.
4079:Molecular Cell
4062:
4035:(2): 255–269.
4018:
3969:
3920:
3887:
3850:(3): 453–461.
3830:
3795:(2): 246–254.
3778:
3729:
3700:(2): 298–309.
3680:
3631:
3590:
3579:(3): 207–216.
3563:
3544:(2): 233–266.
3528:
3513:
3490:
3464:
3428:
3409:(8): 527–533.
3392:
3385:
3367:
3360:
3342:
3283:
3276:
3258:
3215:
3196:(3): 227–233.
3180:
3145:
3115:(3): 399–406.
3095:
3035:
2992:
2943:
2894:
2865:(1): 353–358.
2845:
2801:
2772:(1–2): 87–94.
2756:
2728:
2699:(2): 689–698.
2679:
2664:
2646:
2627:(1–3): 15–19.
2607:
2572:
2542:
2512:
2484:
2454:
2410:
2391:(2): 120–135.
2375:
2338:
2316:
2275:
2246:(3): 784–790.
2226:
2185:
2160:
2133:(6): 515–517.
2117:
2090:(2): 156–167.
2074:
2039:
2012:(5): 466–468.
1995:
1966:(5): 683–741.
1943:
1936:
1918:
1899:(1): 216–236.
1880:
1844:
1841:on 2014-02-16.
1818:
1777:
1734:
1715:(6): 417–441.
1695:
1694:
1692:
1689:
1681:cardiomyocytes
1631:
1627:
1623:
1611:
1608:
1558:
1555:
1553:
1550:
1533:
1530:
1507:) reacts with
1488:
1485:
1473:
1470:
1440:
1437:
1423:
1420:
1407:
1404:
1399:
1395:
1365:
1362:
1357:
1356:Lung infection
1354:
1349:
1346:
1333:
1330:
1324:
1321:
1311:
1308:
1292:
1291:
1287:
1273:
1272:
1270:
1269:
1266:
1264:
1261:
1253:
1252:
1251:
1248:
1247:
1245:
1244:
1241:
1233:
1232:
1231:
1228:
1227:
1225:
1224:
1216:
1214:
1206:
1205:
1199:
1193:
1192:
1184:
1178:
1177:
1173:
1172:
1170:
1169:
1161:
1159:
1153:
1152:
1150:
1149:
1141:
1139:
1133:
1132:
1130:
1129:
1122:
1114:
1112:
1106:
1105:
1103:
1102:
1094:
1092:
1086:
1085:
1083:
1082:
1074:
1072:
1066:
1065:
1063:
1062:
1054:
1052:
1046:
1045:
1043:
1042:
1034:
1032:
1026:
1025:
1023:
1022:
1014:
1012:
1001:
1000:
998:
997:
989:
987:
981:
980:
978:
977:
974:
966:
965:
964:
961:
960:
956:
955:
953:
952:
949:
937:
923:
921:
915:
914:
910:
909:
907:
906:
893:
891:
885:
884:
881:
879:administration
873:
872:
870:
869:
867:
857:
855:
847:
846:
844:
843:
826:
808:
806:
800:
799:
792:
782:
781:
778:
772:
771:
767:
766:
748:
745:
733:
730:
705:
702:
663:plant hormones
656:abiotic stress
582:
579:
571:cardiac muscle
488:
485:
469:
466:
442:
439:
422:
419:
415:metalloenzymes
406:
403:
286:
283:
257:saliva testing
219:
216:
208:
175:
172:
100:
97:
95:
92:
67:in the liver.
57:nitroglycerine
15:
9:
6:
4:
3:
2:
7337:
7326:
7323:
7321:
7318:
7316:
7313:
7312:
7310:
7300:
7290:
7289:
7286:
7275:
7274:
7271:
7265:
7258:
7254:
7251:
7248:
7245:
7241:
7238:
7234:
7231:
7227:
7224:
7221:
7217:
7214:
7211:
7207:
7203:
7200:
7197:
7194:
7190:
7183:
7180:
7176:
7172:
7168:
7165:
7162:
7161:
7158:
7155:
7153:
7147:
7145:
7142:
7140:
7134:
7132:
7129:
7127:
7124:
7122:
7119:
7117:
7114:
7111:
7110:
7107:
7100:
7098:
7092:
7089:
7088:
7086:
7082:
7072:
7069:
7067:
7066:Calmidazolium
7064:
7063:
7061:
7059:
7055:
7049:
7046:
7044:
7041:
7039:
7036:
7034:
7031:
7029:
7026:
7024:
7021:
7019:
7016:
7014:
7007:
7005:
7002:
7001:
6999:
6997:
6993:
6983:
6980:
6978:
6975:
6973:
6970:
6968:
6965:
6963:
6960:
6958:
6955:
6953:
6950:
6948:
6945:
6943:
6940:
6938:
6935:
6933:
6930:
6929:
6927:
6923:
6917:
6914:
6912:
6901:
6899:
6888:
6886:
6883:
6882:
6880:
6878:
6874:
6868:
6865:
6863:
6860:
6858:
6847:
6845:
6834:
6832:
6821:
6819:
6816:
6814:
6811:
6809:
6806:
6804:
6801:
6799:
6796:
6794:
6791:
6789:
6786:
6784:
6781:
6779:
6776:
6774:
6771:
6769:
6766:
6764:
6761:
6759:
6756:
6754:
6751:
6750:
6748:
6746:
6742:
6736:
6733:
6731:
6728:
6726:
6723:
6721:
6710:
6708:
6697:
6695:
6688:
6686:
6683:
6681:
6678:
6676:
6673:
6671:
6668:
6666:
6663:
6661:
6658:
6656:
6653:
6651:
6648:
6646:
6643:
6641:
6638:
6637:
6635:
6633:
6629:
6626:
6624:
6620:
6617:
6613:
6607:
6603:
6597:
6594:
6592:
6589:
6587:
6584:
6582:
6579:
6577:
6574:
6571:
6570:
6567:
6564:
6562:
6559:
6557:
6554:
6552:
6549:
6547:
6542:
6539:
6537:
6534:
6532:
6528:
6525:
6524:
6521:
6518:
6516:
6513:
6511:
6508:
6506:
6503:
6501:
6498:
6496:
6493:
6491:
6488:
6486:
6483:
6481:
6477:
6476:
6473:
6470:
6468:
6465:
6463:
6460:
6458:
6454:
6451:
6450:
6447:
6444:
6442:
6436:
6433:
6431:
6428:
6426:
6423:
6421:
6418:
6416:
6413:
6411:
6408:
6406:
6403:
6401:
6398:
6396:
6393:
6391:
6388:
6386:
6383:
6381:
6378:
6376:
6371:
6369:
6365:
6363:
6360:
6358:
6356:
6352:
6350:
6347:
6345:
6342:
6340:
6337:
6335:
6334:Hexyl nitrite
6332:
6330:
6329:Ethyl nitrite
6327:
6325:
6322:
6320:
6317:
6315:
6309:
6297:
6295:
6291:
6287:
6286:
6283:
6280:
6277:
6275:
6272:
6270:
6267:
6265:
6262:
6260:
6257:
6255:
6252:
6250:
6247:
6245:
6242:
6240:
6237:
6235:
6232:
6230:
6218:
6216:
6213:
6211:
6208:
6206:
6203:
6201:
6198:
6196:
6193:
6191:
6188:
6186:
6183:
6181:
6178:
6176:
6173:
6171:
6168:
6166:
6163:
6161:
6158:
6156:
6153:
6151:
6148:
6146:
6143:
6141:
6137:
6136:
6134:
6130:
6124:
6120:
6110:
6107:
6104:
6103:
6100:
6097:
6095:
6092:
6090:
6087:
6085:
6082:
6080:
6077:
6075:
6072:
6070:
6067:
6065:
6062:
6060:
6057:
6055:
6052:
6049:
6048:
6046:
6044:
6040:
6037:
6035:
6031:
6025:
6022:
6020:
6017:
6015:
6012:
6011:
6009:
6007:
6003:
5999:
5996:
5993:
5986:
5981:
5979:
5974:
5972:
5967:
5966:
5963:
5952:
5948:
5944:
5940:
5936:
5932:
5928:
5924:
5916:
5908:
5904:
5900:
5896:
5892:
5888:
5884:
5880:
5872:
5864:
5860:
5855:
5850:
5845:
5840:
5836:
5832:
5828:
5821:
5807:
5803:
5796:
5782:
5778:
5771:
5756:
5750:
5735:
5731:
5725:
5711:
5710:
5705:
5698:
5696:
5687:
5683:
5678:
5673:
5668:
5663:
5659:
5655:
5651:
5644:
5629:
5625:
5619:
5605:
5604:
5599:
5592:
5578:
5577:
5576:Boston Herald
5572:
5565:
5551:
5550:
5545:
5538:
5530:
5526:
5521:
5516:
5512:
5508:
5504:
5497:
5489:
5485:
5480:
5475:
5471:
5467:
5463:
5459:
5455:
5448:
5440:
5436:
5432:
5428:
5424:
5420:
5413:
5405:
5401:
5397:
5393:
5389:
5385:
5378:
5376:
5367:
5363:
5359:
5355:
5351:
5347:
5343:
5339:
5332:
5324:
5320:
5314:
5306:
5302:
5297:
5292:
5288:
5284:
5280:
5273:
5265:
5261:
5257:
5253:
5246:
5238:
5234:
5229:
5224:
5220:
5216:
5212:
5208:
5204:
5197:
5189:
5185:
5180:
5175:
5171:
5167:
5163:
5156:
5148:
5144:
5140:
5136:
5131:
5126:
5122:
5118:
5111:
5103:
5099:
5094:
5089:
5085:
5081:
5077:
5070:
5062:
5058:
5053:
5048:
5044:
5040:
5037:(2): 91–103.
5036:
5032:
5028:
5021:
5013:
5009:
5005:
5001:
4997:
4993:
4986:
4978:
4974:
4970:
4966:
4962:
4958:
4954:
4950:
4943:
4935:
4931:
4927:
4923:
4918:
4913:
4909:
4905:
4901:
4894:
4886:
4882:
4878:
4874:
4870:
4866:
4862:
4858:
4850:
4842:
4838:
4834:
4830:
4826:
4822:
4815:
4799:
4797:
4791:
4785:
4769:
4765:
4759:
4757:
4739:
4737:
4732:
4731:"Inomax EPAR"
4726:
4724:
4722:
4720:
4718:
4701:
4697:
4691:
4689:
4680:
4676:
4671:
4666:
4661:
4656:
4652:
4648:
4644:
4640:
4636:
4629:
4621:
4617:
4613:
4612:
4607:
4600:
4592:
4588:
4583:
4578:
4573:
4568:
4564:
4560:
4556:
4552:
4548:
4541:
4533:
4529:
4524:
4519:
4514:
4509:
4505:
4501:
4497:
4490:
4482:
4478:
4473:
4468:
4463:
4458:
4454:
4450:
4446:
4439:
4431:
4427:
4422:
4417:
4413:
4409:
4405:
4401:
4397:
4390:
4382:
4378:
4373:
4368:
4364:
4360:
4356:
4352:
4348:
4341:
4333:
4329:
4324:
4319:
4315:
4311:
4307:
4303:
4299:
4292:
4284:
4280:
4275:
4270:
4265:
4260:
4256:
4252:
4248:
4244:
4240:
4233:
4225:
4221:
4216:
4211:
4206:
4201:
4197:
4193:
4189:
4185:
4181:
4174:
4172:
4163:
4159:
4154:
4149:
4144:
4139:
4135:
4131:
4127:
4120:
4112:
4108:
4103:
4098:
4093:
4088:
4084:
4080:
4076:
4069:
4067:
4058:
4054:
4050:
4046:
4042:
4038:
4034:
4030:
4022:
4014:
4010:
4005:
4000:
3996:
3992:
3988:
3984:
3980:
3973:
3965:
3961:
3956:
3951:
3947:
3943:
3940:(7205): 274.
3939:
3935:
3931:
3924:
3915:
3910:
3906:
3902:
3898:
3891:
3883:
3879:
3875:
3871:
3866:
3861:
3857:
3853:
3849:
3845:
3841:
3834:
3826:
3822:
3818:
3814:
3810:
3806:
3802:
3798:
3794:
3790:
3782:
3774:
3770:
3765:
3760:
3756:
3752:
3748:
3744:
3740:
3733:
3725:
3721:
3717:
3713:
3708:
3703:
3699:
3695:
3691:
3684:
3676:
3672:
3668:
3664:
3659:
3654:
3650:
3646:
3645:FASEB Journal
3642:
3635:
3627:
3623:
3618:
3613:
3609:
3605:
3601:
3594:
3586:
3582:
3578:
3574:
3567:
3559:
3555:
3551:
3547:
3543:
3539:
3532:
3524:
3517:
3509:
3505:
3501:
3497:
3493:
3487:
3483:
3479:
3475:
3468:
3460:
3456:
3452:
3448:
3444:
3440:
3432:
3424:
3420:
3416:
3412:
3408:
3404:
3396:
3388:
3382:
3378:
3371:
3363:
3357:
3353:
3346:
3338:
3334:
3329:
3324:
3319:
3314:
3310:
3306:
3302:
3298:
3294:
3287:
3279:
3273:
3269:
3262:
3254:
3250:
3246:
3242:
3238:
3234:
3230:
3226:
3219:
3211:
3207:
3203:
3199:
3195:
3191:
3184:
3176:
3172:
3168:
3164:
3160:
3156:
3149:
3140:
3136:
3131:
3126:
3122:
3118:
3114:
3110:
3106:
3099:
3090:
3086:
3081:
3076:
3071:
3066:
3062:
3058:
3054:
3050:
3046:
3039:
3031:
3027:
3023:
3019:
3015:
3011:
3007:
3003:
2996:
2988:
2984:
2980:
2976:
2971:
2966:
2962:
2958:
2954:
2947:
2939:
2935:
2931:
2927:
2922:
2917:
2913:
2909:
2905:
2898:
2890:
2886:
2881:
2876:
2872:
2868:
2864:
2860:
2856:
2849:
2841:
2837:
2833:
2829:
2825:
2821:
2817:
2813:
2805:
2797:
2793:
2788:
2787:2027.42/31140
2783:
2779:
2775:
2771:
2767:
2760:
2752:
2748:
2744:
2740:
2732:
2724:
2720:
2715:
2710:
2706:
2702:
2698:
2694:
2690:
2683:
2675:
2671:
2667:
2661:
2657:
2650:
2642:
2638:
2634:
2630:
2626:
2622:
2618:
2611:
2603:
2599:
2595:
2591:
2587:
2583:
2576:
2562:
2561:
2556:
2549:
2547:
2532:
2531:
2526:
2519:
2517:
2502:
2498:
2491:
2489:
2474:
2473:
2468:
2461:
2459:
2450:
2446:
2442:
2438:
2434:
2430:
2426:
2422:
2414:
2406:
2402:
2398:
2394:
2390:
2386:
2379:
2371:
2367:
2363:
2359:
2355:
2351:
2350:
2342:
2327:
2320:
2312:
2308:
2303:
2298:
2294:
2290:
2289:Oral Diseases
2286:
2279:
2271:
2267:
2262:
2257:
2253:
2249:
2245:
2241:
2237:
2230:
2222:
2218:
2213:
2208:
2204:
2200:
2196:
2189:
2175:on 2013-10-04
2174:
2170:
2164:
2156:
2152:
2148:
2144:
2140:
2136:
2132:
2128:
2121:
2113:
2109:
2105:
2101:
2097:
2093:
2089:
2085:
2078:
2070:
2066:
2062:
2058:
2054:
2050:
2043:
2035:
2031:
2027:
2023:
2019:
2015:
2011:
2007:
1999:
1991:
1987:
1982:
1977:
1973:
1969:
1965:
1961:
1957:
1950:
1948:
1939:
1933:
1929:
1922:
1914:
1910:
1906:
1902:
1898:
1894:
1887:
1885:
1876:
1872:
1868:
1864:
1860:
1856:
1848:
1840:
1836:
1832:
1825:
1823:
1814:
1810:
1805:
1800:
1796:
1792:
1788:
1781:
1773:
1769:
1765:
1761:
1757:
1753:
1749:
1745:
1738:
1730:
1726:
1722:
1718:
1714:
1710:
1703:
1701:
1696:
1688:
1686:
1682:
1678:
1674:
1670:
1666:
1662:
1658:
1654:
1650:
1646:
1643:
1639:
1638:
1621:
1617:
1607:
1605:
1601:
1597:
1593:
1589:
1588:Mount Everest
1585:
1581:
1576:
1572:
1568:
1564:
1549:
1547:
1544:secondary to
1543:
1539:
1529:
1526:
1520:
1518:
1514:
1513:peroxynitrite
1510:
1506:
1502:
1497:
1494:
1484:
1482:
1477:
1469:
1467:
1464:, and severe
1463:
1459:
1455:
1450:
1446:
1445:nitroglycerin
1436:
1434:
1430:
1419:
1417:
1413:
1403:
1393:
1388:
1385:
1383:
1379:
1375:
1371:
1361:
1353:
1345:
1343:
1339:
1338:methemoglobin
1329:
1320:
1318:
1307:
1303:
1300:
1296:
1288:
1285:
1280:
1279:
1278:
1265:
1260:
1259:
1256:
1249:
1240:
1239:
1236:
1229:
1222:
1218:
1217:
1215:
1212:
1207:
1200:
1198:
1194:
1185:
1183:
1179:
1174:
1167:
1166:ChEMBL1200689
1163:
1162:
1160:
1158:
1154:
1147:
1143:
1142:
1140:
1138:
1134:
1127:
1123:
1120:
1116:
1115:
1113:
1111:
1107:
1100:
1096:
1095:
1093:
1091:
1087:
1080:
1076:
1075:
1073:
1071:
1067:
1060:
1056:
1055:
1053:
1051:
1047:
1040:
1036:
1035:
1033:
1031:
1027:
1020:
1016:
1015:
1013:
1006:
1002:
995:
991:
990:
988:
986:
982:
973:
972:
969:
962:
957:
950:
948:
938:
935:
925:
924:
922:
920:
916:
911:
903:
898:
895:
894:
892:
890:
886:
882:
880:
874:
868:
859:
858:
856:
854:
848:
841:
836:
827:
824:
819:
810:
809:
807:
805:
801:
797:
793:
791:
787:
783:
779:
777:
773:
770:Clinical data
768:
764:
759:
751:
744:
741:
740:
729:
727:
723:
719:
715:
711:
701:
699:
695:
691:
687:
682:
680:
676:
675:Abscisic acid
672:
668:
664:
659:
657:
654:and controls
653:
649:
644:
642:
638:
634:
630:
626:
622:
618:
614:
611:
607:
602:
600:
596:
592:
588:
578:
576:
572:
567:
565:
561:
557:
551:
549:
545:
541:
536:
534:
530:
526:
522:
518:
514:
510:
509:smooth muscle
506:
502:
498:
494:
491:Nitric oxide
484:
482:
478:
473:
465:
463:
459:
455:
450:
448:
438:
436:
432:
428:
418:
416:
412:
402:
399:
395:
391:
387:
383:
382:inflammometer
378:
376:
373:
370:
366:
361:
356:
354:
353:iron-nitrosyl
350:
346:
345:
340:
339:free radicals
336:
332:
328:
324:
320:
316:
312:
308:
304:
296:
291:
282:
280:
276:
272:
270:
267:
263:
258:
254:
250:
246:
242:
238:
232:
229:
225:
215:
212:
206:
202:
198:
194:
190:
186:
185:Nitroglycerin
182:
167:
163:
160:
154:
151:
147:
143:
141:
137:
133:
129:
126:-nitrogen of
125:
121:
117:
113:
112:acetylcholine
109:
105:
91:
89:
85:
81:
77:
73:
68:
66:
62:
58:
54:
50:
47:
43:
39:
35:
31:
27:
25:
21:
7269:
7268:
7244:paraxanthine
7220:beta blocker
7163:
7112:
7090:
6894:-ornithine (
6827:-ornithine (
6572:
6551:Feprosidnine
6546:Sydnonimines
6544:
6529:
6526:
6478:
6455:
6452:
6441:nitrosamines
6438:
6373:
6367:
6354:
6311:
6288:
6138:
6105:
6084:GSK-2181236A
6050:
5992:Nitric oxide
5926:
5922:
5915:
5882:
5878:
5871:
5834:
5830:
5820:
5809:. Retrieved
5795:
5784:. Retrieved
5770:
5759:. Retrieved
5749:
5738:. Retrieved
5736:. 2020-06-24
5724:
5713:. Retrieved
5707:
5657:
5653:
5643:
5631:. Retrieved
5627:
5618:
5607:. Retrieved
5601:
5591:
5580:. Retrieved
5574:
5564:
5553:. Retrieved
5547:
5537:
5510:
5506:
5496:
5461:
5457:
5447:
5422:
5418:
5412:
5387:
5383:
5341:
5337:
5331:
5322:
5313:
5286:
5282:
5272:
5255:
5251:
5245:
5210:
5206:
5196:
5169:
5165:
5155:
5120:
5116:
5110:
5083:
5079:
5069:
5034:
5030:
5020:
4995:
4991:
4985:
4952:
4948:
4942:
4907:
4903:
4893:
4863:(1): 76–82.
4860:
4856:
4849:
4824:
4820:
4814:
4802:. Retrieved
4793:
4784:
4772:. Retrieved
4767:
4742:. Retrieved
4734:
4704:. Retrieved
4699:
4642:
4638:
4628:
4620:the original
4609:
4599:
4554:
4550:
4540:
4523:11343/283842
4503:
4499:
4489:
4452:
4448:
4438:
4403:
4399:
4389:
4354:
4350:
4340:
4305:
4301:
4291:
4246:
4242:
4232:
4187:
4183:
4133:
4129:
4119:
4082:
4078:
4032:
4028:
4021:
3986:
3982:
3972:
3937:
3933:
3923:
3907:(2): 246–7.
3904:
3900:
3890:
3847:
3844:FEBS Letters
3843:
3833:
3792:
3788:
3781:
3746:
3742:
3732:
3697:
3693:
3683:
3648:
3644:
3634:
3607:
3603:
3593:
3576:
3572:
3566:
3541:
3537:
3531:
3522:
3516:
3473:
3467:
3442:
3438:
3431:
3406:
3402:
3395:
3376:
3370:
3351:
3345:
3300:
3296:
3286:
3267:
3261:
3228:
3224:
3218:
3193:
3189:
3183:
3161:(1): 87–94.
3158:
3154:
3148:
3112:
3108:
3098:
3052:
3048:
3038:
3005:
3001:
2995:
2960:
2956:
2946:
2911:
2907:
2897:
2862:
2858:
2848:
2815:
2811:
2804:
2769:
2765:
2759:
2745:(1): 23–31.
2742:
2738:
2731:
2696:
2692:
2682:
2655:
2649:
2624:
2620:
2610:
2585:
2581:
2575:
2564:. Retrieved
2558:
2534:. Retrieved
2528:
2504:. Retrieved
2500:
2476:. Retrieved
2470:
2424:
2420:
2413:
2388:
2385:Nitric Oxide
2384:
2378:
2353:
2347:
2341:
2330:. Retrieved
2319:
2292:
2288:
2278:
2243:
2240:Hypertension
2239:
2229:
2202:
2199:Hypertension
2198:
2188:
2177:. Retrieved
2173:the original
2163:
2130:
2126:
2120:
2087:
2083:
2077:
2052:
2049:Nitric Oxide
2048:
2042:
2009:
2005:
1998:
1963:
1959:
1927:
1921:
1896:
1892:
1858:
1854:
1847:
1839:the original
1834:
1794:
1791:Hypertension
1790:
1780:
1747:
1743:
1737:
1712:
1708:
1653:CB2 receptor
1635:
1613:
1560:
1535:
1521:
1490:
1487:Pharmacology
1478:
1475:
1442:
1425:
1409:
1406:Neonatal use
1389:
1386:
1367:
1359:
1351:
1335:
1326:
1313:
1304:
1301:
1297:
1293:
1276:
975:Nitric oxide
919:Legal status
913:Legal status
840:Nitric_oxide
804:License data
755:Nitric oxide
750:
747:Medical uses
737:
735:
717:
709:
707:
683:
660:
645:
641:chloroplasts
633:mitochondria
631:, including
613:root nodules
603:
584:
568:
552:
548:hypertension
537:
490:
474:
471:
451:
444:
424:
408:
381:
379:
357:
342:
300:
277:
273:
249:hypertensive
233:
221:
213:
200:
189:amyl nitrite
180:
177:
159:vasodilation
155:
144:
108:shear stress
102:
72:neuroscience
69:
61:amyl nitrite
30:Nitric oxide
28:
24:nitric oxide
19:
18:
7257:simvastatin
7091:Precursors:
7028:epicatechin
6952:Indospicine
6907:-arginine (
6853:-arginine (
6788:AR-C 102222
6716:-arginine (
6703:-arginine (
6566:Sydnonimine
6299:Nitrite (NO
6282:Trolnitrate
6278:Tenitramine
6220:Nitrate (NO
6106:Inhibitors:
6089:Praliciguat
6069:BAY 60-4552
6064:BAY 41-8543
6059:BAY 41-2272
4190:(1): 4020.
2295:(1): 7–16.
2055:: 123–130.
1835:TedxGlasgow
1685:equilibrium
1669:reperfusion
1616:cannabinoid
1317:hypotension
1204: g·mol
1146:CHEBI:16480
959:Identifiers
776:Trade names
726:nitrophorin
722:kissing bug
652:proteolysis
637:peroxisomes
599:cut flowers
435:Nitrosation
411:nitrosation
394:breath test
355:compounds.
335:interleukin
315:neutrophils
311:macrophages
7309:Categories
7230:sildenafil
7210:nifedipine
7113:Cofactors:
7102:N-Hydroxy-
7009:N-Hydroxy-
6798:Canavanine
6793:BYK-191023
6612:inhibitors
6541:REC15/2739
6520:V-PYRRO/NO
6210:Nicorandil
6099:Vericiguat
5998:modulators
5811:2020-07-05
5786:2020-07-05
5761:2020-06-25
5740:2020-06-25
5715:2020-06-25
5609:2020-06-25
5582:2020-07-27
5555:2020-07-14
4904:Hepatology
3989:: pls052.
3983:AoB Plants
3303:(64): 64.
3093:Free text.
2566:2020-05-31
2536:2020-05-31
2506:2020-06-28
2478:2020-07-09
2332:2013-10-04
2179:2013-10-04
1691:References
1525:sulfhydryl
1509:superoxide
1449:denitrated
1433:amputation
1429:neuropathy
1209:3D model (
1197:Molar mass
1099:31C4KY9ESH
1070:ChemSpider
1030:IUPHAR/BPS
994:10102-43-9
985:CAS Number
968:IUPAC name
883:Inhalation
648:N-end rule
621:root hairs
575:heart rate
521:Sildenafil
507:active on
499:. Also a
344:Leishmania
303:phagocytes
266:antiseptic
140:calmodulin
132:citrulline
128:L-arginine
80:immunology
76:physiology
7270:See also:
7216:Nebivolol
7175:captopril
7097:-Arginine
7038:norvaline
7033:ornithine
6947:GW-273629
6903:N-Methyl-
6849:N-Methyl-
6840:-lysine (
6712:N-Propyl-
6699:N-Methyl-
6680:ARL-17477
6573:Unsorted:
6123:NO donors
6094:Riociguat
6074:BI-703704
6054:Ataciguat
5995:signaling
5125:CiteSeerX
4934:205894350
4885:128175609
4700:Drugs.com
4057:254285519
4029:Biometals
3143:free text
2356:(4): 33.
1665:ischaemia
1618:compound
1422:Pathology
877:Routes of
851:Pregnancy
796:Monograph
790:Drugs.com
679:cytokinin
458:aconitase
360:apoptosis
307:monocytes
269:mouthwash
262:DASH diet
193:minoxidil
124:guanidine
116:cytokines
7299:Medicine
7237:caffeine
7202:blockers
7193:bosentan
7179:losartan
6996:Arginase
6982:VAS-2381
6977:ONO-1714
6925:Unsorted
6685:Indazole
6591:FR146881
6586:FR144220
6576:Cimlanod
6531:Furoxans
6510:PROLI/NO
6480:NONOates
6430:SNO-t-PA
6294:nitrites
6205:NCX-4215
6200:NCX 4040
6195:NCX-4016
6190:NCX-2216
6140:Nitrates
6129:prodrugs
5951:32450365
5943:21309057
5907:24074568
5899:16444588
5863:32387333
5686:15650225
5633:10 April
5603:Newsweek
5529:22005573
5488:18246091
5439:22119378
5366:28911682
5358:16371634
5305:10690334
5264:17375630
5237:28056166
5188:16870913
5147:16870914
5102:26205960
5061:28130308
5012:17197767
4977:11063073
4969:15378046
4926:25130427
4877:31009091
4841:29051000
4768:DailyMed
4679:19841256
4591:23319631
4532:29658100
4481:26829981
4430:22171938
4381:34890464
4332:34618055
4283:29033328
4224:31488841
4162:32052059
4111:24462115
4049:23322177
4013:23372921
3964:10426722
3882:34725559
3874:17240373
3825:23329722
3817:16397797
3773:15347796
3724:24712179
3716:11791016
3675:45447939
3667:15333581
3626:11017941
3558:15866322
3508:25597341
3500:19089323
3459:10406194
3337:20973949
3253:14587150
3245:26208702
3210:26095908
3139:16544944
2987:12612236
2938:45487458
2840:21034574
2674:52342536
2602:26197209
2560:Fatherly
2501:NBC News
2449:32190689
2441:22549282
2405:19879370
2370:28353075
2311:23837897
2270:18250365
2221:23589565
2155:36184793
2104:18167491
2069:24120618
2034:46833231
2026:12207094
1990:19219851
1913:15598503
1729:10390607
1677:training
1661:diabetic
1642:neonatal
1637:Cannabis
1563:COVID-19
1557:COVID-19
1552:Research
1517:paraquat
1505:ischemia
1454:neonates
1050:DrugBank
889:ATC code
866: B2
853:category
835:DailyMed
698:necrosis
688:of most
686:stomates
671:ethylene
665:such as
625:stomatal
587:homologs
564:clitoris
544:diabetes
431:cysteine
245:beetroot
150:isoforms
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6185:NCX-466
6034:Targets
5854:7200356
5806:WCVB-TV
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5404:8638524
5228:6464941
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4670:2775278
4647:Bibcode
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4559:Bibcode
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4421:3324642
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4323:8644111
4274:5668231
4251:Bibcode
4215:6728379
4192:Bibcode
4153:7260729
4102:3969242
4004:3560241
3955:1126920
3852:Bibcode
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3423:7658698
3328:2984475
3305:Bibcode
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3130:2570754
3089:1557408
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2930:1903415
2889:7516412
2880:2191552
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2641:2126524
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1981:2725214
1875:9277574
1813:1977698
1772:1361684
1752:Bibcode
1744:Science
1673:hypoxic
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237:spinach
228:biofilm
224:nitrate
181:in vivo
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