Knowledge

Chlorpyrifos

Source ๐Ÿ“

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also found on work boots and children's hands, showing that agricultural families could take home these residues from their jobs. Urban and suburban children get most of their chlorpyrifos exposure from fruits and vegetables. A study done in North Carolina on children's exposure showed that chlorpyrifos was detected in 50% of the food, dust, and air samples in both their homes and daycare, with the main route of exposure being through ingestion. Certain other populations with higher likely exposure to chlorpyrifos, such as people who apply pesticides, work on farms, or live in agricultural communities, have been measured in the US to excrete TCPy in their urine at levels that are 5 to 10 times greater than levels in the general population.
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cohort of 7-year-old children was studied for neurological damage from prenatal exposure to chlorpyrifos. The study determined that the exposed children had deficits in working memory and full scale intelligence quotient (IQ). In a study on groups of Chinese infants, those exposed to chlorpyrifos showed significant decreases in motor functions such as reflexes, locomotion, and grasping at 9 months compared to those not exposed. Exposure to organophosphate pesticides in general has been increasingly associated with changes in children's cognitive, behavioral and motor performance. Infant girls were shown to be more susceptible to harmful effects from organophosphate insecticides than infant boys.
1229:, for three days in utero and then to low levels of chlorpyrifos for four days after birth experienced additional damage to the acetylcholine system upstream of the synapse that was not observed with either exposure alone. In both male and female rats, combined exposures to dexamethasone and chlorpyrifos decreased serotonin turnover in the synapse, for female rats with a greater-than-additive result. Rats that were co-exposed to dexamethasone and chlorpyrifos also exhibited complex behavioral differences from exposure to either chemical alone, including lessening or reversing normal sex differences in behavior. In the lab, in rats and neural cells co-exposed to both 780: 733:. As of August 18, 2021, the U.S. Environmental Protection Agency (EPA) announced a ban on the use of chlorpyrifos on food crops in the United States. Most home uses of chlorpyrifos had already been banned in the U.S. and Canada since 2001. It is banned in several other countries and jurisdictions as well. The chlorpyrifos ban on food crops is the result of a 1999 lawsuit filed by NRDC to force the EPA to take action on the riskiest pesticides, as well as five additional successful court orders obtained by Earthjustice to force the EPA to take action on a 2007 petition to ban chlorpyrifos filed by 359: 264: 1203:. In laboratory animals, additional PON1 protects against chlorpyrifos toxicity while individuals that do not produce PON1 are particularly susceptible. In humans, studies about the effect of PON1 activity on the toxicity of chlorpyrifos and other organophosphates are mixed, with modest yet inconclusive evidence that higher levels of PON1 activity may protect against chlorpyrifos exposure in adults; PON1 activity may be most likely to offer protection from low-level chronic doses. Human populations have 11964: 1399: 22: 1267:(CARB) documented chlorpyrifos in the air of California communities. Analyses indicate that children living in areas of high chlorpyrifos use are often exposed to levels that exceed EPA dosages. A study done in Washington state using passive air samplers showed that households who lived less than 250 meters from a fruit tree field had higher levels of chlorpyrifos concentrations in the air than households that were further away. Advocacy groups monitored air samples in 793: 11975: 1363: 98: 1126: 11995: 89: 12005: 11985: 11954: 1252:
environment. According to the National Institutes of Health, the half-life for chlorpyrifos (i.e., the period of time that it takes for the active amount of the chemical to decrease by 50%) "can typically range from 33โ€“56 days for soil incorporated applications and 7โ€“15 days for surface applications"; in water, the half-life is about 25 days, and in the air, the half-life can range from four to ten days.
1028:. It is suggested that adolescents differ from adults in the metabolism of these compounds due to the maturation of organs in adolescents. This results in disruption in nervous system developmental processes, as observed in animal experiments. There are several studies observed in animals that show that chlorpyrifos alters the expression of essential genes that assist in the development of the brain. 648: 1698:
In 2006, to reduce childhood exposure, the EPA amended its chlorpyrifos tolerance on apples, grapes and tomatoes, reducing the grape and apple tolerances to 0.01 ppm and eliminating the tolerance on tomatoes. Chlorpyrifos is not allowed on crops such as spinach, squash, carrots, and tomatoes; any chlorpyrifos residue on these crops normally represents chlorpyrifos misuse or spray drift.
1694:โ€ณThe ... exposures for chlorpyrifos are of risk concern ... for all population subgroups analyzed. Children (1โ€“2 years old) is the population subgroup with the highest risk estimate at 14,000% of the ssPADfood.โ€ณ (This acronym refers to the steady-state population-adjusted dose for food, which is considered the maximum safe oral dose.) 1904:) did not set a usage limits for chlorpyrifos. In 2010, India barred Dow from commercial activity for 5 years after India's Central Bureau of Investigation found Dow guilty of bribing Indian officials in 2007 to allow the sale of chlorpyrifos. In 2020, the Indian government had published a draft bill to ban 27 pesticides including chlorpyrifos. 1349:
less walking; more grooming, particularly of the head; more difficulty righting themselves; and unusual abdominal spasms. Chlorpyrifos oxon appears to particularly inhibit acetylcholinesterase in bee gut tissue as opposed to head tissue. Other organophosphate pesticides impaired bee learning and memory of smells in the laboratory.
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In Hawaii, a 2018 law introduced a complete ban on products containing chlorpyrifos, which went into effect on January 1, 2023. Before that, starting in 2019, the law mandated temporary application permits and annual reporting as well as mandating a 100-foot buffer around schools during school hours.
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Food handling establishments (places where food products are held, processed, prepared or served) are included in the food tolerance of 0.1 ppm for chlorpyrifos. Food handling establishments may use a 0.5% solution of chlorpyrifos solely for spot and/or crack and crevice treatments. Food items are to
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In an 30 October 2015 statement Dow AgroSciences disagreed with the EPA's proposed revocation and "remain confident that authorized uses of chlorpyrifos products, as directed, offer wide margins of protection for human health and safety." In a November 2016 press release, DOW argued that chlorpyrifos
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Children of agricultural workers are more likely to come into contact with chlorpyrifos. A study done in an agricultural community in Washington State showed that children who lived in closer proximity to farmlands had higher levels of chlorpyrifos residues from house dust. Chlorpyrifos residues were
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Chlorpyrifos was used in about 100 countries around the world to control insects in agricultural, residential, and commercial settings. Its use in residential applications is restricted in multiple countries. According to Dow, chlorpyrifos is registered for use in nearly 100 countries and is annually
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released a statement in July 2019 which concluded that the approval criteria for chlorpyrifos which apply to human health are not met. Their literature review concluded that there is no evidence for reproductive toxicity in rats, but that chlorpyrifos is potentially genotoxic. The report stated that
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Based on 2006 EPA rules, chlorpyrifos has a tolerance of 0.1 part per million (ppm) residue on all food items unless a different tolerance has been set for that item or chlorpyrifos is not registered for use on that crop. EPA set approximately 112 tolerances pertaining to food products and supplies.
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on food commodities. The FFDCA requires EPA to set limits, known as tolerances, for pesticide residue in human food and animal feed products based on risk quotients for acute and chronic exposure from food in humans. These tolerances limit the amount of chlorpyrifos that can be applied to crops. FDA
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banning all neurotoxic insecticide on all food crops. The court concluded, that by deciding to ban all uses of chlorpyrifos on food plants, the EPA ignored the long standing American practice and prior court orders to evaluate each crop group on its own merits and "to keep a set of high-benefit uses
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in PANNA v. EPA ordered the EPA to respond to PANNA's petition by "revok all tolerances for the insecticide chlorpyrifos", den the Petition or a "proposed or final tolerance revocation" no later than 31 October 2015. The EPA was "unable to conclude that the risk from aggregate exposure from the use
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symptoms. Relatively mild poisoning can result in eye-watering, increased saliva and sweating, nausea, and headache. Intermediate exposure may lead to muscle spasms or weakness, vomiting, or diarrhea, and impaired vision. Symptoms of severe poisoning include seizures, unconsciousness, paralysis, and
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EPA estimated that, between 1987 and 1998, about 21 million pounds of chlorpyrifos were used annually in the US. In 2001, chlorpyrifos ranked 15th among pesticides used in the United States, with an estimated 8 to 11 million pounds applied. In 2007, it ranked 14th among pesticide ingredients used in
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responded to the administration's decision saying they are "deeply alarmed" by Pruitt's decision to allow the pesticide's continued use. "There is a wealth of science demonstrating the detrimental effects of chlorpyrifos exposure to developing fetuses, infants, children and pregnant women. The risk
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in pollen and components of bee hives. A review of US studies, several European countries, Brazil and India found chlorpyrifos in nearly 15% of hive pollen samples and just over 20% of honey samples. Because of its high toxicity and prevalence in pollen and honey, bees are considered to have higher
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As of 2016, chlorpyrifos was the most used conventional insecticide in the US and was used in over 40 states; the top five states (in total pounds applied) are California, North Dakota, Minnesota, Iowa, and Texas. It was used on over 50 crops, with the top five crops (in total pounds applied) being
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Among 50 farm pesticides studied, chlorpyrifos was associated with higher risks of lung cancer among frequent pesticide applicators than among infrequent or non-users. Pesticide applicators as a whole were found to have a 50% lower cancer risk than the general public, likely due to their nearly 50%
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In August, it was revealed that in fact Pruitt and other EPA officials had met with industry representatives on dozens of occasions in the weeks immediately prior to the March decision, promising them that it was "a new day" and assuring them that their wish to continue using chlorpyrifos had been
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In November 2016, the EPA reassessed its ban proposal after taking into consideration recommendations made by the agency's Science Advisory Panel which had rejected the EPA's methodology in quantifying the risk posed by chlorpyrifos. Using a different methodology as suggested by the panel, the EPA
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Chlorpyrifos is one of the most widely used pest control products in the world. It is authorized for use in about 100 nations, including the U.S., Canada, the United Kingdom, Spain, France, Italy, Japan, Australia and New Zealand, where it is registered for protection of essentially every crop now
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When exposed in the laboratory to chlorpyrifos at levels roughly estimated from measurements in hives, bee larvae experienced 60% mortality over 6 days, compared with 15% mortality in controls. Adult bees exposed to sub-lethal effects of chlorpyrifos (0.46 ng/bee) exhibited altered behaviors:
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that may influence the effectiveness of PON1 at detoxifying chlorpyrifos oxon and the amount of PON1 available to do so. Some evidence indicates that children born to women with low PON1 may be particularly susceptible to chlorpyrifos exposure. Further, infants produce low levels of PON1 until six
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and a stronger, longer-lasting signal to the next neuron. Only when new molecules of acetylcholinesterase have been synthesized can normal function return. Acute symptoms of chlorpyrifos poisoning only occur when more than 70% of acetylcholinesterase molecules are inhibited. This mechanism is well
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and established maximum and continuous concentration limits of 0.025 ppb and 0.015 ppb, respectively. Sale and possession of chlorpyrifos have been largely banned in California, as of 6 February โ€“ 31 December 2020, respectively. The California ban has an exception that, "a few products that apply
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The EPA has not updated the approximately 112 tolerances pertaining to food products and supplies since 2006. However, in a 2016 report, EPA scientists had not been able to find any level of exposure to the pesticide that was safe. The EPA 2016 report states in part "... this assessment indicates
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Humans can be exposed to chlorpyrifos by way of ingestion (e.g., residue on treated produce, drinking water), inhalation (especially of indoor air), or absorption (i.e., through the skin). However, compared to other organophosphates, chlorpyrifos degrades relatively quickly once released into the
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Chlorpyrifos may affect other neurotransmitters, enzymes and cell signaling pathways, potentially at doses below those that substantially inhibit acetylcholinesterase. The extent of and mechanisms for these effects remain to be fully characterized. Laboratory experiments in rats and cell cultures
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Eddleston, Michael; Eyer, Peter; Worek, Franz; Mohamed, Fahim; Senarathna, Lalith; von Meyer, Ludwig; Juszczak, Edmund; Hittarage, Ariyasena; Azhar, Shifa; Dissanayake, Wasantha; Sheriff, M. H. Rezvi; Szinicz, Ladislaus; Dawson, Andrew H.; Buckley, Nick A. (28 October 2005). "Differences between
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Additional laws and guidelines may apply for individual US states. California, Hawaii, Maryland, New York, and Oregon, have banned chlorpyrifos on food grown and sold in their jurisdictions. These State bans remain in effect regardless whether chlorpyrifos is allowed on the federal level or not.
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After years of research without a conclusion and cognizant of the court order to issue a final ruling, the EPA proposed to eliminate all tolerances for chlorpyrifos ("Because tolerances are the maximum residue of a pesticide that can be in or on food, this proposed rule revoking all chlorpyrifos
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system. Moreover, experiments with zebrafish showed significant detriments to survivability, reproductive processes, and motor function. Varying doses created a 30%โ€“100% mortality rate of embryos after 90 days. Embryos were shown to have decreased mitosis, resulting in mortality or developmental
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Sparks, Thomas C.; Crossthwaite, Andrew J.; Nauen, Ralf; Banba, Shinichi; Cordova, Daniel; Earley, Fergus; Ebbinghaus-Kintscher, Ulrich; Fujioka, Shinsuke; Hirao, Ayako; Karmon, Danny; Kennedy, Robert; Nakao, Toshifumi; Popham, Holly J.R.; Salgado, Vincent; Watson, Gerald B.; Wedel, Barbara J.;
1753:, EPA agreed to re-instate no-spray stream buffer zones in California, Oregon and Washington, restricting aerial spraying (300 ft.) and ground-based applications (60 ft.) near salmon populations. These buffers will remain until EPA makes a permanent decision in consultation with NMFS. 1319:(2013) all experienced insect, shrimp, or fish kills as a result of small releases of concentrated chlorpyrifos. The July 2013 release along the River Kennet poisoned insect life and shrimp along 15 km of the river, likely from a half a cup of concentrated chlorpyrifos washed down a drain. 1247:
is 0.3 micrograms/kg/day. However, as of 2016, EPA scientists had not been able to find any level of exposure to the pesticide that was safe. The EPA 2016 report states in part "... this assessment indicates that dietary risks from food alone are of concern ..." The report also states that
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Twelve people who had been exposed to chlorpyrifos were studied over periods of 1 to 4.5 years. They were found to have a heightened immune responses to common allergens and increased antibiotic sensitivities, elevated CD26 cells, and a higher rate of autoimmunity, compared with control groups.
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and neurological changes such as slower motor development and attention problems. Children with prenatal exposure to chlorpyrifos have been shown to have lower IQs. They have also been shown to have a higher chance of developing autism, attention deficit problems, and developmental disorders. A
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Epidemiological and experimental animal studies suggest that infants and children are more susceptible than adults to the effects of low-dose exposure. Chlorpyrifos has been suggested to have negative impacts on cognitive functions in the developing brain. The young have a decreased capacity to
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Thomas, Kent W.; Dosemeci, Mustafa; Hoppin, Jane A.; Sheldon, Linda S.; Croghan, Carry W.; Gordon, Sydney M.; Jones, Martin L.; Reynolds, Stephen J.; Raymer, James H.; Akland, Gerald G.; Lynch, Charles F.; Knott, Charles E.; Sandler, Dale P.; Blair, Aaron E.; Alavanja, Michael C. (March 2010).
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requires owners and operators of agricultural businesses to comply with safety protocols for agricultural workers and pesticide handlers (those who mix, load and apply pesticides). For example, in 2005, the EPA filed an administrative complaint against JSH Farms, Inc. (Wapato, Washington) with
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In 2011, EPA estimated that, in the general US population, people consume 0.009 micrograms of chlorpyrifos per kilogram of their body weight per day directly from food residue. Children are estimated to consume a greater quantity of chlorpyrifos per unit of body weight from food residue, with
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in the brain develop. Exposure leads to reductions or reversals of normal gender differences. Exposure to low levels of chlorpyrifos early in rat life or as adults also affects metabolism and body weight. These rats show increased body weight as well as changes in liver function and chemical
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Acute poisoning is probably most common in agricultural areas in Asia, where many small farmers are affected. Poisoning may be due to occupational or accidental exposure or intentional self-harm. Precise numbers of chlorpyrifos poisonings globally are not available. Pesticides are used in an
1337:, with an oral LD50 of 360 ng/bee and a contact LD50 of 70 ng/bee. Guidelines for Washington state recommend that chlorpyrifos products should not be applied to flowering plants such as fruit trees within 4โ€“6 days of blossoming to prevent bees from directly contacting the residue. 3251:
Eddleston, Michael; Eyer, Peter; Worek, Franz; Juszczak, Edmund; Alder, Nicola; Mohamed, Fahim; Senarathna, Lalith; Hittarage, Ariyasena; Azher, Shifa; Jeganathan, K.; Jayamanne, Shaluka; von Meyer, Ludwig; Dawson, Andrew H.; Sheriff, Mohamed Hussain Rezvi; Buckley, Nick A. (June 2009).
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Pawar, Kirti S; Bhoite, Ramesh R.; Pillay, Chandrakant P.; Chavan, Sujata C.; Malshikare, Dhananjay S.; Garad, Saraswati G. (22 December 2006). "Continuous pralidoxime infusion versus repeated bolus injection to treat organophosphorus pesticide poisoning: a randomised controlled trial".
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and soil-born insects. The chemical became widely used in residential settings, on golf course turf, as a structural termite control agent, and in agriculture. Most residential use of chlorpyrifos has been phased out in the United States; however, agricultural use remains common.
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Cao, Fangjie; Souders, Christopher L.; Li, Pengfei; Pang, Sen; Qiu, Lihong; Martyniuk, Christopher J. (2018). "Biological impacts of organophosphates chlorpyrifos and diazinon on development, mitochondrial bioenergetics, and locomotor activity in zebrafish (Danio rerio)".
1049:: In experiments with rats, early, short-term low-dose exposure to chlorpyrifos resulted in lasting neurological changes, with larger effects on emotional processing and cognition than on motor skills. Such rats exhibited behaviors consistent with depression and reduced 11584: 4862:
Qiao, Dan; Seidler, Frederic J.; Violin, Jonathan D.; Slotkin, Theodore A. (30 December 2003). "Nicotine is a developmental neurotoxicant and neuroprotectant: stage-selective inhibition of DNA synthesis coincident with shielding from effects of chlorpyrifos".
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that dietary risks from food alone are of concern ..." the report also states that previous published risk assessments for "chlorpyrifos may not provide a  ... human health risk assessment given the potential for neurodevelopmental outcomes."
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On 9 August 2018 the U.S. 9th Circuit court of Appeals ruled that the EPA must ban chlorpyrifos within 60 days from that date. A spokesman for Dow DuPont stated that "all appellate options" would be considered. In contrast, Marisa Ordonia, a lawyer for
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retained its decision to completely ban chlorpyrifos. The EPA concluded that, while "uncertainties" remain, a number of studies provide "sufficient evidence" that children experience neurodevelopment effects even at low levels of chlorpyrifos exposure.
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On February 25, 2022 the EPA released a statement upholding its decision to revoke all tolerance standards on chlorpyrifos use, and sent letters to registered chlorpyrifos food producers confirming the ban to be in effect as of February 28, 2022.
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Smith, Jordan Ned; Hinderliter, Paul M.; Timchalk, Charles; Bartels, Michael J.; Poet, Torka S. (1 August 2014). "A human life-stage physiologically based pharmacokinetic and pharmacodynamic model for chlorpyrifos: Development and validation".
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estimated 200,000+ suicides annually with tens of thousands due to chlorpyrifos. Organophosphates are thought to constitute two-thirds of ingested pesticides in rural Asia. Chlorpyrifos is among the commonly used pesticides used for self-harm.
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Connors, Susan L.; Levitt, Pat; Matthews, Stephen G.; Slotkin, Theodore A.; Johnston, Michael V.; Kinney, Hannah C.; Johnson, William G.; Dailey, Rosa M.; Zimmerman, Andrew W. (March 2008). "Fetal Mechanisms in Neurodevelopmental Disorders".
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heard. Ryan Jackson, Pruitt's chief of staff, said in an 8 March email that he had "scared" career staff into going along with the political decision to deny the ban, adding "hey know where this is headed and they are documenting it well."
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The Dow Chemical Company is actively opposed to tolerance restrictions on chlorpyrifos and is currently lobbying the White House to, among other goals, pressure EPA to reverse its proposal to revoke chlorpyrifos food residue tolerances.
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in experimental animals is 32 to 1000 mg/kg. The dermal LD50 in rats is greater than 2000 mg/kg and 1000 to 2000 mg/kg in rabbits. The 4-hour inhalation of LC50 for chlorpyrifos in rats is greater than 200 mg/m.
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soybeans, corn, alfalfa, oranges, and almonds. Additionally, crops with 30% or more of the crop treated (compared to total acres grown) include apples, asparagus, walnuts, table grapes, cherries, cauliflower, broccoli, and onions.
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proposed penalties of $ 1,680 for using chlorpyrifos in 2004 without proper equipment. An adjacent property was contaminated with chlorpyrifos due to pesticide drift and the property owner suffered from eye and skin irritation.
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baits with childproof packaging. In 2000, manufacturers reached an agreement with the EPA to voluntarily restrict the use of chlorpyrifos in places where children may be exposed, including homes, schools and day care centers.
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and chlorpyrifos, nicotine appears to protect against chlorpyrifos acetylcholinesterase inhibition and reduce its effects on neurodevelopment. In at least one study, nicotine appeared to enhance chlorpyrifos detoxification.
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in 1966, which had a lower acute toxicity (WHO class III), but this appears to be no longer in commercial use. The molecule is similar to Chlorpyrifos ethyl, but with a O,O dimethyl chain. Proposed applications included
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Chlorpyrifos is normally supplied as a 23.5% or 50% liquid concentrate. The recommended concentration for direct-spray pin point application is 0.5% and for wide area application a 0.03โ€“0.12% mix is recommended (US).
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Hoppin, Jane A.; Umbach, David M.; London, Stephanie J.; Alavanja, Michael C. R.; Sandler, Dale P. (1 March 2002). "Chemical predictors of wheeze among farmer pesticide applicators in the Agricultural Health Study".
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Several studies have examined the effects of combined exposure to chlorpyrifos and other chemical agents, and these combined exposures can result in different effects during development. Female rats exposed first to
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toddlers the highest at 0.025 micrograms of chlorpyrifos per kilogram of their body weight per day. People may also ingest chlorpyrifos from drinking water or from residue in food handling establishments. The EPA's
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Chlorpyrifos is used agriculturally in Australia but household use was restricted to low strength solutions in 2001 and banned in 2020. There are 49 registered chlorpyrifos insecticide products, mostly as 500 g/L
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Muรฑoz-Quezada, Maria Teresa; Lucero, Boris A.; Barr, Dana B.; Steenland, Kyle; Levy, Karen; Ryan, P. Barry; Iglesias, Veronica; Alvarado, Sergio; Concha, Carlos; Rojas, Evelyn; Vega, Catalina (December 2013).
1275:, in 2006 with comparable results. Grower and pesticide industry groups argued that the air levels documented in these studies are not high enough to cause significant exposure or adverse effects. A follow-up 1616:
Asked in April whether Pruitt had met with Dow Chemical Company executives or lobbyists before his decision, an EPA spokesman replied: "We have had no meetings with Dow on this topic." In June, after several
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Giddings, Jeffrey M.; Williams, W. Martin; Solomon, Keith R.; Giesy, John P. (2014). "Risks to Aquatic Organisms from Use of Chlorpyrifos in the United States". In Giesy, John P.; Solomon, Keith R. (eds.).
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Chlorpyrifos was banned under by Department of Agriculture for use in farming and agriculture with effective from year 2023. However it is still permitted for general use other than agriculture purpose.
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of the European parliament and of the council of 16 February 1998, concerning the placing of biocidal products on the market. Published in the Official Journal of the European Communities, 24 April 1998
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lower smoking rate. However, chlorpyrifos applicators had a 15% lower cancer risk than the general public, which the study suggests indicates a link between chlorpyrifos application and lung cancer.
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control in Singapore as of 2009. It was banned from residential use in South Africa as of 2010. It has been banned in the United Kingdom in 2016 apart from a limited use in drenching seedlings.
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Adults may develop lingering health effects following acute exposure or repeated low-dose exposure. Among agricultural workers, chlorpyrifos has been associated with slightly increased risk of
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at a hotel in Houston, Texas, on 9 March. Both men were featured speakers at an energy conference. An EPA spokesperson reported that the meeting was brief and the pesticide was not discussed.
11579: 6834: 4441:; Nadel, Lynn; Neubert, Diether; Schulte-Hermann, Rolf; Spencer, Peter S. (January 2008). "Review of the toxicology of chlorpyrifos with an emphasis on human exposure and neurodevelopment". 3333: 9288: 2792:
Rauh, Virginia A.; Perera, Frederica P.; Horton, Megan K.; Whyatt, Robin M.; Bansal, Ravi; Hao, Xuejun; Liu, Jun; Barr, Dana Boyd; Slotkin, Theodore A.; Peterson, Bradley S. (15 May 2012).
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previous published risk assessments for "chlorpyrifos may not provide a sufficiently health protective human health risk assessment given the potential for neurodevelopmental outcomes."
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Brodan, Bolton insecticide, Chlorpyrifos-ethyl, Cobalt, Detmol UA, Dowco 179, Dursban, Empire, Eradex, Hatchet, Lorsban, Nufos, Paqeant, Piridane, Scout, Stipend, Tricel, Warhawk, others
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Chlorpyrifos was banned under Thai law effective from 1 June 2020. Farmers were given 270 days to destroy their stock, while a 90-day deadline was also given to farmers to return the
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and insects appear to be more sensitive to acute exposure than fish. Aquatic insects and animals appear to absorb chlorpyrifos directly from water rather than ingesting it with their
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of chlorpyrifos the safety standard of section 408(b)(2) of the Federal Food, Drug, and Cosmetic Act (FFDCA)" and therefore proposed "to revoke all tolerances for chlorpyrifos."
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Some states, including California, Hawaii, Maryland, New York, and Oregon, have banned chlorpyrifos on food grown and sold in their jurisdictions. Those bans remain in effect.
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On 14 December, 2022 the EPA filed a Notice of Intent to Cancel (NOIC) for three chlorpyrifos pesticide products because they bear labeling for use on food, despite the ban.
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based on acute toxicity information dating to 1999. Exposure surpassing recommended levels has been linked to neurological effects, persistent developmental disorders, and
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Levin, Edward D.; Cauley, Marty; Johnson, Joshua E.; Cooper, Ellen M.; Stapleton, Heather M.; Ferguson, P. Lee; Seidler, Frederic J.; Slotkin, Theodore A. (January 2014).
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vacated EPA's order for these labeling requirements. In August 2014, in the settlement of a suit brought by environmental and fisheries advocacy groups against EPA in the
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The Australian Pesticides and Veterinary Medicine Authority has been doing a Chlorpyrifos Chemical Review since July 2015, with the decision expected in August of 2024.
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Chlorpyrifos was used to control insect infestations of homes and commercial buildings in Europe until it was banned from sale in 2008. Chlorpyrifos is restricted from
9159: 4562:"Prenatal dexamethasone augments the sex-selective developmental neurotoxicity of chlorpyrifos: Implications for vulnerability after pharmacotherapy for preterm labor" 3631:
Bouchard, Maryse F.; Chevrier, Jonathan; Harley, Kim G.; Kogut, Katherine; Vedar, Michelle; Calderon, Norma; Trujillo, Celina; Johnson, Caroline; Bradman, Asa (2011).
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Curwin, Brian D.; Hein, Misty J.; Sanderson, Wayne T.; Striley, Cynthia; Heederik, Dick; Kromhout, Hans; Reynolds, Stephen J.; Alavanja, Michael C. (1 January 2007).
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Risk assessments have primarily considered acute exposure, but more recently researchers have begun to investigate the effects of chronic, low-level exposure through
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in place." The court ordered the EPA to reevaluate whether "chlorpyrifos can be safely used on crops like sugar beets, soybeans, and certain fruits and vegetables".
5703:. Reviews of Environmental Contamination and Toxicology, Continuation of Residue Reviews. Vol. 231. Cham: Springer International Publishing. pp. 119โ€“162. 1978: 11747: 9243: 9085: 4321:
Slotkin, T A (15 July 2004). "Cholinergic systems in brain development and disruption by neurotoxicants: nicotine, environmental tobacco smoke, organophosphates".
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Lee, Won Jin; Blair, Aaron; Hoppin, Jane A.; Lubin, Jay H.; Rusiecki, Jennifer A.; Sandler, Dale P.; Dosemeci, Mustafa; Alavanja, Michael C. R. (1 December 2004).
1569:(collectively, PANNA) submitted an administrative petition requesting a chlorpyrifos ban, citing harm to the brains of developing children. On 10 August 2015, the 7218: 725:, the use of chlorpyrifos was banned as of 1 April 2016 (with one minor exception). As of 2020, chlorpyrifos and chlorpyrifos-methyl were banned throughout the 3488:
Timofeeva, Olga A.; Levin, Edward D. (2010). "Lasting Behavioral Consequences of Organophosphate Pesticide Exposure During Development". In R. Krieger (ed.).
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Act). In the event of an environmental release above its reportable quantity of 1 lb or 0.454 kg, facilities are required to immediately notify the
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Total Maximum Daily Loads for Chlorpyrifos and Diazinon for the Pajaro River Watershed Monterey, Santa Clara, Santa Cruz, and San Benito Counties, California
2735:
Chishti, Zia; Hussain, Sarfraz; Arshad, Khaliq R.; Khalid, Azeem; Arshad, Muhammad (2013). "Microbial degradation of chlorpyrifos in liquid media and soil".
2054: 1746: 1651: 1470: 938:
Children are more likely to experience muscle weakness rather than twitching; excessive saliva rather than sweat or tears; seizures; and sleepiness or coma.
730: 588: 10846: 7171: 6996: 5145:"Exposures of 129 Preschool Children to Organochlorines, Organophosphates, Pyrethroids, and Acid Herbicides at Their Homes and Daycares in North Carolina" 1549:
Chlorpyrifos is sold in restricted-use products for certified pesticide applicators to use in agriculture and other settings, such as golf courses or for
1010:
in 2011. Thai investigators came to no conclusion on the subject, but maintain that chlorpyrifos was not responsible and that the deaths were not linked.
11712: 10746: 10742: 10738: 10734: 10711: 10707: 2290: 1067:
and lower motor functions were observed. The same study showed that chlorpyrifos had more severe morphological deformities and mortality in embryos than
5794: 2620: 7219:"Regulatory Developments: Court of Appeals Issues Landmark Ruling Vacating Biological Opinion Concerning Effects of Three Pesticides on Salmon Species" 6295: 3595: 661: 7725:"Statement on the available outcomes of the human health assessment in the context of the pesticides peer review of the active substance chlorpyrifos" 7434:. 895 Aerovista Place, Suite 101, San Luis Obispo, California 93401: CALIFORNIA REGIONAL WATER QUALITY CONTROL BOARD CENTRAL COAST REGION. p. 65. 7021: 11742: 11198: 9258: 6407: 6844: 6644: 5301:
Egeghy, Peter P.; Cohen Hubal, Elaine A.; Tulve, Nicolle S.; Melnyk, Lisa J.; Morgan, Marsha K.; Fortmann, Roy C.; Sheldon, Linda S. (24 May 2011).
4227:
Thrasher, JD; Madison, R; Broughton, A (Marchโ€“April 1993). "Immunologic abnormalities in humans exposed to chlorpyrifos: preliminary observations".
11702: 7680: 3341: 2400: 6933: 5627: 2532: 1924:
for destruction, as their possession is considered illegal by the Department of Agriculture. After deadline, any person who possesses the illegal
1741:(NMFS) recommended limits on the use of chlorpyrifos in California, Idaho, Oregon and Washington and requested that manufacturers voluntarily add 10558: 9513: 9371: 7460: 2676: 2477: 1834:
chlorpyrifos in granular form, representing less than one percent of agricultural use of chlorpyrifos, will be allowed to remain on the market."
1640:
On August 18, 2021 the U.S. Environmental Protection Agency (EPA) announced a ban on the use of chlorpyrifos on food crops in the United States.
7837: 7091:"Tolerances and Exemptions for Pesticide Chemical Residues in Food [ 40 CFR 180 ] : (Protection of Environment [ 40 CFR ])" 6206: 10879: 10298: 10294: 10290: 10286: 9523: 9480: 9431: 1621:
requests, the EPA released a copy of Pruitt's March meeting schedule which showed that a meeting had been scheduled between Pruitt and Dow CEO
1409: 32: 5958:
Williamson, Sally M.; Moffat, Christopher; Gomersall, Martha A. E.; Saranzewa, Nastja; Connolly, Christopher N.; Wright, Geraldine A. (2013).
5744: 11634: 9908: 9485: 9351: 8505: 3882:
Perera, FP (2005). "A Summary of Recent Findings on Birth Outcomes and Developmental Effects of Prenatal ETS, PAH, and Pesticide Exposures".
2313: 1912:
Chlorpyrifos is currently approved in New Zealand for commercial use in crops, as a veterinary medicine, and as a timber treatment chemical.
1578:
was "a critical tool for growers of more than 50 different types of crops in the United States" with limited or no viable alternatives." The
6373: 3438:
Flaskos, J. (25 February 2012). "The developmental neurotoxicity of organophosphorus insecticides: A direct role for the oxon metabolites".
1765:(TRI), based on EPA assessments. Chlorpyrifos is not on the reporting list. It is on the list of hazardous substances under CERCLA (aka the 11887: 11601: 9466: 9366: 8910: 8040: 6071: 5771: 5657: 5568: 3168:
Buckley, Nick A.; Eddleston, Michael; Li, Yi; Bevan, Marc; Robertson, Jane (2011). "Oximes for acute organophosphate pesticide poisoning".
2238: 1901: 408: 181: 7194:"Registrants' Response to EPA's April 29, 2010 Letter: Implementation of Chlorpyrifos, Diazinon and Malathion Salmonid BiOp-Davids letter" 5479:"Passive Sampling for Indoor and Outdoor Exposures to Chlorpyrifos, Azinphos-Methyl, and Oxygen Analogs in a Rural Agricultural Community" 4910: 11825: 10477: 10158: 10143: 10133: 10128: 10123: 10118: 10113: 10108: 10103: 9642: 9582: 9572: 9436: 9336: 8955: 1788:(PEL) of 0.2 mg/m3 for chlorpyrifos, based on an 8-hour time weighted average (TWA) exposure. However, the rule was remanded by the 2852: 2372:"The EPA is banning chlorpyrifos, a pesticide widely used on food crops, after 14 years of pressure from environmental and labor groups" 1683:
tolerances means that if this approach is finalized, all agricultural uses of chlorpyrifos would cease."), and then solicited comments.
1473:
and should be restricted. In 2021, the European Union submitted a proposal to list chlorpyrifos in Annex A to the Stockholm Convention.
10223: 8849: 8635: 5453: 4975: 1844:
In 2003, Dow agreed to pay $ 2 million to New York state, in response to a lawsuit to end Dow's advertising of Dursban as "safe".
1812: 1618: 5890:"Four common pesticides, their mixtures and a formulation solvent in the hive environment have high oral toxicity to honey bee larvae" 5535: 11663: 9968: 9456: 6615: 6492: 5197:"Urinary biomarker, dermal, and air measurement results for 2,4-D and chlorpyrifos farm applicators in the Agricultural Health Study" 4437:
Eaton, David L.; Daroff, Robert B.; Autrup, Herman; Bridges, James; Buffler, Patricia; Costa, Lucio G.; Coyle, Joseph; McKhann, Guy;
1497: 1158:
established for acute chlorpyrifos poisoning and also some lower-dose health impacts. It is also the primary insecticidal mechanism.
4684:"Prenatal dexamethasone augments the neurobehavioral teratology of chlorpyrifos: Significance for maternal stress and preterm labor" 2590: 779: 12029: 11707: 11569: 10163: 7797: 5378: 4503:. Emerging health issues from chronic pesticide exposure: Innovative methodologies and effects on molecular cell and tissue level. 4154: 1702:
be removed or protected during treatment. Food handling establishment tolerances may be modified or exempted under FFDCA sec. 408.
1502:
In the United States, several laws directly or indirectly regulate the use of pesticides. These laws, which are implemented by the
7863: 4627:"Prenatal dexamethasone, as used in preterm labor, worsens the impact of postnatal chlorpyrifos exposure on serotonergic pathways" 12049: 11677: 9923: 9798: 7090: 7048: 4807:"Reversal of chlorpyrifos neurobehavioral teratogenicity in mice by nicotine administration and neural stem cell transplantation" 4805:
Billauer-Haimovitch, Hana; Slotkin, Theodore A.; Dotan, Sharon; Langford, Rachel; Pinkas, Adi; Yanai, Joseph (28 December 2009).
2700:
Simon, David; Helliwell, Stuart; Robards, Kevin (1998). "Analytical chemistry of chlorpyrifos and diuron in aquatic ecosystems".
2110: 1880:
On 6 December 2019, the European Union (EU) announced that it will no longer permit sales of chlorpyrifos after 31 January 2020.
729:, where they may no longer be used. The EU also applied to have chlorpyrifos listed as a persistent organic pollutant under the 7961: 7266: 3751:
Silver, Monica K.; Shao, Jie; Zhu, Binquan; Chen, Minjian; Xia, Yankai; Kaciroti, Niko; Lozoff, Betsy; Meeker, John D. (2017).
2558: 1562: 7386: 6181: 6108:"UNEP/POPS/POPRC.17/5 โ€“ Proposal to list chlorpyrifos in Annex A to the Stockholm Convention on Persistent Organic Pollutants" 6107: 3753:"Prenatal naled and chlorpyrifos exposure is associated with deficits in infant motor function in a cohort of Chinese infants" 1776:
In 1995, Dow paid a $ 732,000 EPA penalty for not forwarding reports it had received on 249 chlorpyrifos poisoning incidents.
12034: 11668: 11616: 11521: 5716: 3505: 2342: 2139:"Insecticides, biologics and nematicides: Updates to IRAC's mode of action classification - a tool for resistance management" 2022: 951: 7918: 6438: 3993:. Prenatal Programming and Toxicity II (PPTOX II): Role of Environmental Stressors in the Developmental Origins of Disease. 12008: 11871: 11682: 11611: 11536: 11355: 6965: 6816: 3691:
Rauh, Virginia; Arunajadai, Srikesh; Horton, Megan; Perera, Frederica; Hoepner, Lori; Barr, Dana B.; Whyatt, Robin (2011).
2878: 6539: 4941: 12039: 11859: 11737: 10720: 10633: 7724: 7510: 2737: 1819:
Subbasin as part of the Columbia River National Strategic Plan, which is based on EPA'S 2006โ€“11 National Strategic Plan.
1711: 6079:
Pesticide Action Network North America, Oakland, CA. WWW. Pan-europe. Info/News/PR/121009_Chlorpyrifos_as_POP_final. PDF
5602:"Heather Hansen, "Proper Pest Management Keeps Washington Fruit Crop Healthy", Seattle Post Intellegencer, Jan 19, 2007" 1985: 656: 10872: 10689: 9493: 7536: 6131: 3407: 3311: 11876: 11835: 11800: 11785: 11767: 11692: 11471: 5254:"Urinary pesticide concentrations among children, mothers and fathers living in farm and non-farm households in Iowa" 2500: 2086: 1841:
Florida did not ban chlorpyrifos completely, but introduced a concentration limit of 21 ug/L in drinking water.
1738: 1566: 1462: 1439: 734: 373: 66: 7120: 6934:
US Environmental Protection Agency Office of Pesticide Programs Reregistration Eligibility Decision for Chlorpyrifos
5088:"Dietary Intake and Its Contribution to Longitudinal Organophosphorus Pesticide Exposure in Urban/Suburban Children" 3819:"Neurodevelopmental effects in children associated with exposure to organophosphate pesticides: A systematic review" 842:
through several routes. Simon et al. 1998 report that insects are exposed to chlorpyrifos through ingesting treated
12054: 11881: 11717: 11648: 11643: 9773: 8307: 5303:"Review of pesticide urinary biomarker measurements from selected US EPA children's observational exposure studies" 5001: 3100:"Longitudinal trends in organophosphate incidents reported to the National Pesticide Information Center, 1995โ€“2007" 2652: 1823: 1723: 1002:
Chlorpyrifos poisoning was described by New Zealand scientists as the likely cause of death of several tourists in
7121:"Designation of Hazardous Substances [ 40 CFR 116 ] : (Protection of Environment [ 40 CFR ])" 5143:
Morgan, Marsha; Wilson, Nancy; Chuang, Jane; Morgan, Marsha K.; Wilson, Nancy K.; Chuang, Jane C. (3 April 2014).
668: 11820: 11727: 11591: 11506: 11269: 7753: 7150: 6880: 1655: 1053:. In rats, low-level exposure during development has its greatest neurotoxic effects during the period in which 11849: 11722: 11559: 11526: 9312: 8302: 6782: 6443: 2516:
Bob Egelko (9 May 2019). "Newsom banning chemical on crops: Action outlaws pesticide Trump EPA wants to save".
1889: 1884: 1789: 1609: 1570: 1264: 1150: 1059: 871: 700: 569: 6730: 2452: 11625: 11015: 10865: 9988: 5801: 4750:
Lee, Sookwang; Poet, Torka S.; Smith, Jordan N.; Busby-Hjerpe, Andrea L.; Timchalk, Charles (30 March 2010).
3693:"Seven-Year Neurodevelopmental Scores and Prenatal Exposure to Chlorpyrifos, a Common Agricultural Pesticide" 3382: 3363: 2627: 7587: 6299: 5031:"Children's Exposure to Chlorpyrifos and Parathion in an Agricultural Community in Central Washington State" 11988: 11854: 10836: 10575: 9189: 7445: 6973: 316: 259: 1212:
months to several years after birth, likely increasing the risk from chlorpyrifos exposure early in life.
11908: 11606: 11564: 10918: 9783: 8455: 6839: 6465: 4495:
Costa, Lucio G.; Giordano, Gennaro; Cole, Toby B.; Marsillach, Judit; Furlong, Clement E. (10 May 2013).
3596:"7-Year Neurodevelopmental Scores and Prenatal Exposure to Chlorpyrifos, a Common Agricultural Pesticide" 991: 855: 801:
applied to approximately 8.5 million crop acres. The crops with the most usefulness include cotton,
754: 337: 221: 6966:"Compliance Policy Guides โ€“ CPG Sec. 575.100 Pesticide Residues in Food and Feed โ€“ Enforcement Criteria" 11903: 10468: 10446: 8949: 8262: 7954: 7929: 6940: 6858: 6234:"Concentrations and temporal trends in pesticide biomarkers in urine of Swedish adolescents, 2000โ€“2017" 5635: 4374:"Organophosphate-sensitive lipases modulate brain lysophospholipids, ether lipids and endocannabinoids" 4180:"Cancer incidence among pesticide applicators exposed to chlorpyrifos in the Agricultural Health Study" 2536: 1796: 1785: 1328: 1307:
Concentrated chlorpyrifos released into rivers killed insects, shrimp and fish. In Britain, the rivers
1176: 612: 599: 2683: 954:
shrank sharply from over 200 in the year 2000 to less than 50 in 2003, following the residential ban.
11933: 11653: 9217: 9134: 8382: 8277: 8093: 8025: 6588: 3606: 1958: 1714:
and falls under the CWA amendments of 1977 and 1978. The regulation is inclusive of all chlorpyrifos
907: 867: 711: 692: 9151: 6757:"Scott Pruitt, Trump's EPA chief met with Dow Chemical exec before rolling back a ban on pesticides" 6210: 5406:"Community Exposures to Airborne Agricultural Pesticides in California: Ranking of Inhalation Risks" 583:
acute toxic, environmental hazard, combustible, reacts strongly with amines, strong acids, caustics
12044: 11795: 11156: 11148: 10991: 10663: 10316: 10213: 9938: 7439: 5960:"Exposure to acetylcholinesterase inhibitors alters the physiology and motor function of honeybees" 4752:"Effect of in vivo nicotine exposure on chlorpyrifos pharmacokinetics and pharmacodynamics in rats" 1770: 1762: 1458: 738: 354: 48: 7313: 6325: 2987:
Gunnell, David; Eddleston, Michael; Phillips, Michael R.; Konradsen, Flemming (21 December 2007).
1710:
Chlorpyrifos in waterways is regulated as a hazardous substance under section 311(b)(2)(A) of the
11775: 11687: 11128: 11003: 9127: 8138: 7890: 7613: 2853:
The WHO Recommended Classification of Pesticides by Hazard and Guidelines to Classifiยณcation 2009
7069: 6518:
Dow AgroSciences, U.S. Farmers Disagree with U.S. EPA Proposal to Revoke Chlorpyrifos Tolerances
6082: 6015:"Exposure to multiple cholinergic pesticides impairs olfactory learning and memory in honeybees" 5668: 5575: 2910: 2221:
The WHO Recommended Classification of Pesticides by Hazard and Guidelines to Classification 2019
1171:
signaling and increase rat symptoms of depression; change the expression or activity of several
11843: 11763: 11658: 11481: 11360: 9106: 9066: 8118: 7772: 1523: 1133:
Primarily, chlorpyrifos and other organophosphate pesticides interfere with signaling from the
1054: 7022:"POISON FRUIT: Dow Chemical Wants Farmers to Keep Using a Pesticide Linked to Autism and ADHD" 6562: 2856: 12059: 11865: 11815: 11810: 11554: 11302: 10581: 10502: 9120: 7947: 7416: 6688: 6671: 4497:"Paraoxonase 1 (PON1) as a genetic determinant of susceptibility to organophosphate toxicity" 2426:"Canada Quietly Bans Chlorpyrifos, While EPA's 60-Day Deadline For Action Rapidly Approaches" 1854: 550: 5460: 4372:
Casida, John E.; Nomura, Daniel K.; Vose, Sarah C.; Fujioka, Kazutoshi (25 September 2008).
695:
that has been used on crops, animals, and buildings, and in other settings, to kill several
11978: 11292: 11121: 10976: 10431: 9778: 9298: 8267: 5901: 5842: 5601: 5542: 4763: 4695: 4573: 4508: 4385: 4330: 4060: 3998: 3987:"Does early-life exposure to organophosphate insecticides lead to prediabetes and obesity?" 3891: 3830: 3764: 3254:"Pralidoxime in acute organophosphorus insecticide poisoningโ€”A randomised controlled trial" 3111: 2805: 2750: 2709: 2154: 987: 982:, which reduces the pesticide's impact. However, atropine does not affect acetylcholine at 704: 325: 110: 7193: 6903: 6494:
Chlorpyrifos Tolerance Revocations: A Proposed Rule by the Environmental Protection Agency
2597: 812:
Chlorpyrifos was first registered for use in the United States in 1965 for the control of
241: 157: 8: 11938: 11697: 11395: 10592: 10492: 10421: 10238: 10188: 9713: 9099: 8829: 8425: 8287: 8282: 8098: 8083: 6506:
Docket number EPA-HQ-OPP-2015-0653. This report is no longer available on the EPA website
2256: 1542:). As a pesticide, chlorpyrifos is not regulated under the Toxic Substances Control Act ( 1279:
study in Lindsay also showed that people there display above-normal chlorpyrifos levels.
1272: 979: 851: 715: 147: 11994: 7485: 5905: 5846: 5454:"S Kegley et al., "Secondhand Pesticides", Pesticide Action Network North America, 2003" 5382: 4767: 4699: 4577: 4512: 4389: 4334: 4161: 4064: 4002: 3952: 3895: 3834: 3768: 3115: 2809: 2754: 2713: 2220: 2158: 1376:
Please help update this article to reflect recent events or newly available information.
1038:
studies, chlorpyrifos exposure during gestation or childhood has been linked with lower
358: 263: 201: 11596: 11549: 11491: 11375: 11047: 10309: 10013: 9192: 9092: 9078: 8974: 8775: 8297: 8292: 8128: 8113: 8075: 6817:"Court Orders E.P.A. To Ban Chlorpyrifos, Pesticide Tied to Children's Health Problems" 6709: 6268: 6233: 6047: 6014: 5986: 5959: 5932: 5889: 5865: 5830: 5698: 5511: 5478: 5430: 5405: 5329: 5302: 5229: 5196: 5171: 5144: 5120: 5087: 5063: 5030: 4839: 4806: 4724: 4683: 4659: 4642: 4626: 4602: 4561: 4560:
Slotkin, Theodore A.; Card, Jennifer; Infante, Alice; Seidler, Frederic J. (May 2013).
4537: 4496: 4470: 4414: 4373: 4092: 4027: 3986: 3915: 3859: 3818: 3793: 3752: 3725: 3692: 3665: 3632: 3497: 3288: 3253: 3233: 3142: 3099: 3080: 3023: 2988: 2828: 2793: 2188: 1949:, eventually reacting 3,5,6-trichloro-2-pyridinol with diethylthiophosphoryl chloride. 1457:
Chlorpyrifos is not regulated under international law or treaty. Organizations such as
1312: 1268: 983: 911: 7098: 4876: 3213: 3060: 2794:"Brain anomalies in children exposed prenatally to a common organophosphate pesticide" 2721: 1979:"California Department of Pestidicide Regulation โ€“ Chlorpyrifos Product List May 2015" 1675:
enforces EPA's pesticide tolerances and determines "action levels" for the unintended
1417: 382:
InChI=1S/C9H11Cl3NO3PS/c1-3-14-17(18,15-4-2)16-9-7(11)5-6(10)8(12)13-9/h5H,3-4H2,1-2H3
40: 11923: 11732: 11418: 11052: 11037: 11019: 10933: 10761: 10703: 10680: 10669: 10208: 10083: 10033: 9983: 9863: 9663: 8630: 8595: 8555: 8103: 6790: 6713: 6701: 6693: 6381: 6273: 6255: 6052: 6034: 5991: 5937: 5919: 5870: 5722: 5712: 5516: 5498: 5435: 5334: 5283: 5275: 5234: 5216: 5176: 5125: 5107: 5068: 5050: 4888: 4880: 4844: 4826: 4787: 4779: 4729: 4711: 4664: 4646: 4607: 4589: 4542: 4524: 4462: 4454: 4438: 4419: 4401: 4354: 4346: 4300: 4292: 4244: 4209: 4201: 4136: 4128: 4084: 4076: 4032: 4014: 3964: 3956: 3907: 3864: 3846: 3798: 3780: 3730: 3712: 3670: 3652: 3576: 3568: 3501: 3463: 3455: 3293: 3275: 3225: 3217: 3181: 3147: 3129: 3072: 3064: 3028: 3010: 2966: 2958: 2833: 2774: 2766: 2496: 2471: 2192: 2180: 2172: 2082: 2018: 1816: 1671: 1421: 1341: 1204: 927: 887: 392:
InChI=1/C9H11Cl3NO3PS/c1-3-14-17(18,15-4-2)16-9-7(11)5-6(10)8(12)13-9/h5H,3-4H2,1-2H3
44: 10765: 7244: 6348:"Chlorpyrifos; Receipt of Requests For End-Use Product Amendments and Cancellations" 4474: 4096: 3919: 3524: 3237: 3084: 3047:
organophosphorus insecticides in human self-poisoning: a prospective cohort study".
2562: 1199:(PON1) detoxifies chlorpyrifos oxon, the more toxic metabolite of chlorpyrifos, via 1145:
acetylcholinesterase, preventing this enzyme from deactivating acetylcholine in the
11574: 11486: 11466: 11314: 11284: 10900: 10795: 10776: 10472: 10273: 10268: 10263: 10258: 10253: 10248: 10243: 10048: 9928: 9918: 9748: 9206: 8834: 8565: 8435: 7394: 6683: 6263: 6245: 6042: 6026: 6010: 5981: 5971: 5927: 5909: 5860: 5850: 5704: 5506: 5490: 5425: 5417: 5324: 5314: 5265: 5224: 5208: 5166: 5156: 5115: 5099: 5058: 5042: 4872: 4834: 4818: 4771: 4719: 4703: 4654: 4638: 4597: 4581: 4532: 4516: 4446: 4409: 4393: 4338: 4284: 4236: 4191: 4120: 4068: 4022: 4010: 4006: 3948: 3899: 3854: 3838: 3788: 3772: 3720: 3704: 3660: 3644: 3560: 3493: 3447: 3283: 3265: 3209: 3177: 3173: 3137: 3119: 3056: 3018: 3000: 2948: 2823: 2813: 2758: 2717: 2162: 1946: 1869: 1172: 1134: 843: 539: 431: 5888:
Zhu, Wanyi; Schmehl, Daniel R.; Mullin, Christopher A.; Frazier, James L. (2014).
4240: 2762: 11790: 11496: 11458: 11428: 11274: 11207: 11072: 11057: 10981: 10948: 10730: 10699: 10613: 10608: 10416: 9703: 9693: 9673: 9113: 9032: 8415: 8400: 5914: 5855: 4124: 3776: 3451: 3270: 2167: 2138: 1726:
for chlorpyrifos, but has established a drinking water guideline of 2 ug/L.
1676: 1519: 1466: 1226: 1208: 1180: 1095:, thyroid gland, myelin, and the subjects also had more anti-nuclear antibodies. 696: 305: 11998: 7912: 7907: 7681:"Fรธdevaremyndighed: Frygtet sprรธjtegift skader bรธrns udvikling og skal forbydes" 6731:"EPA chief met with Dow Chemical CEO before deciding not to ban toxic pesticide" 5708: 3903: 3842: 3564: 1345:
risk from chlorpyrifos exposure via their diet than from many other pesticides.
11913: 11077: 11042: 10938: 10023: 9943: 9698: 9668: 9508: 8930: 8410: 8249: 7798:"Dow raided by CBI: profited $ 330,000 by bribing officials to license Dursban" 7338: 4342: 3633:"Prenatal Exposure to Organophosphate Pesticides and IQ in 7-Year-Old Children" 2067:
Sangster J; LOGKOW Databank. Sangster Res. Lab., Montreal Quebec, Canada (1994)
1622: 1244: 1109: 950:
In the US, the number of incidents of chlorpyrifos exposure reported to the US
883: 839: 726: 722: 639: 10331: 7934: 7486:"Agreement Reached to End Sale of Chlorpyrifos in California by February 2020" 6250: 5477:
Gibbs, Jenna L.; Yost, Michael G.; Negrete, Maria; Fenske, Richard A. (2017).
5029:
Fenske, Richard A.; Lu, Chensheng; Barr, Dana; Needham, Larry (5 April 2002).
4822: 4775: 4707: 4585: 4520: 4450: 4397: 4288: 4275:
Costa, Lucio G. (April 2006). "Current issues in organophosphate toxicology".
4072: 2989:"The global distribution of fatal pesticide self-poisoning: Systematic review" 2953: 2936: 2206: 2050: 1534:); the Comprehensive Environmental Response, Compensation, and Liability Act ( 12023: 11918: 11438: 11246: 11107: 11087: 10998: 10963: 10401: 10233: 10008: 9973: 9848: 9503: 9182: 9014: 8895: 8839: 8811: 8718: 8708: 8540: 8520: 8186: 8151: 7939: 7924: 6794: 6697: 6408:"EPA Proposes Ending Use of Certain Pesticide on Foods, Citing Risk to Water" 6385: 6282:... , as chlorpyrifos has never been approved for plant protection in Sweden. 6259: 6038: 5976: 5923: 5502: 5279: 5220: 5111: 5054: 4911:
Chlorpyrifos Preliminary Human Health Risk Assessment for Registration Review
4884: 4830: 4783: 4715: 4650: 4593: 4528: 4458: 4405: 4350: 4296: 4205: 4132: 4080: 4018: 3960: 3850: 3784: 3716: 3656: 3572: 3459: 3279: 3221: 3133: 3068: 3014: 2962: 2770: 2176: 1734: 1276: 1222: 1196: 975: 931: 924: 891: 528: 518: 252: 6783:"E.P.A. Promised 'a New Day' for the Agriculture Industry, Documents Reveal" 5536:
Air Monitoring for Chlorpyrifos in the Yakima Valley, Washington, April 2006
5270: 5253: 5161: 5086:
Lu, Chensheng; Barr, Dana B.; Pearson, Melanie A.; Waller, Lance A. (2008).
3005: 2937:"Patterns and problems of deliberate self-poisoning in the developing world" 2818: 710:
Chlorpyrifos is considered moderately hazardous to humans (Class II) by the
699:, including insects and worms. It acts on the nervous systems of insects by 11968: 11928: 11443: 11264: 11256: 11097: 11082: 10928: 10757: 10548: 10441: 10396: 10361: 10351: 10346: 10193: 10073: 9978: 9883: 9518: 9401: 9386: 9057: 8999: 8994: 8900: 8875: 8806: 8801: 8771: 8743: 8698: 8693: 8688: 8673: 8620: 8525: 8495: 8395: 8357: 8239: 8229: 8214: 8209: 8199: 8176: 8156: 8005: 7970: 7868: 7823: 6705: 6277: 6056: 5995: 5941: 5874: 5726: 5520: 5439: 5338: 5287: 5238: 5180: 5129: 5072: 4892: 4848: 4791: 4733: 4668: 4625:
Slotkin, Theodore A.; Card, Jennifer; Seidler, Frederic J. (January 2014).
4611: 4546: 4466: 4423: 4358: 4304: 4213: 4140: 4088: 4036: 3968: 3911: 3868: 3802: 3734: 3674: 3580: 3467: 3297: 3229: 3185: 3151: 3124: 3076: 3032: 2970: 2837: 2778: 2621:"Pesticide Industry Sales and Usage Report: 2006 and 2007 Market Estimates" 2184: 1925: 1742: 1634: 1602: 1316: 1308: 1092: 1039: 1035: 7366:"Three Companies Penalized for Pesticide Violations on Yakama Reservation" 5421: 5404:
Lee, S; McLaughlin, R; Harnly, M; Gunier, R; Kreutzer, R (December 2002).
5319: 4248: 4196: 4179: 3098:
Stone, David L.; Sudakin, Daniel L.; Jenkins, Jeffrey J. (20 April 2009).
2105: 1582:
quoted the Dow AgroSciences' statement disagreeing with the EPA findings.
1488:
Chlorpyrifos has not been permitted for agricultural use in Sweden at all
11958: 11544: 11501: 11433: 11413: 11390: 11365: 11169: 11164: 11142: 11135: 11092: 11062: 11032: 10888: 10785: 10623: 10543: 10487: 10381: 10228: 9993: 9893: 9768: 9723: 9567: 9562: 9557: 9490: 9451: 9396: 9381: 9361: 9346: 9072: 8989: 8890: 8880: 8791: 8767: 8758: 8738: 8733: 8723: 8683: 8658: 8640: 8450: 8234: 8204: 8194: 8146: 8123: 8030: 8020: 7974: 7925:
Chlorpyrifos Pesticide Information Profile โ€“ Extension Toxicology Network
7562: 7124: 5046: 1058:
indicators similar to prediabetes, likely associated with changes to the
1025: 1007: 971: 718:. Exposure during pregnancy may harm the mental development of children. 10326: 5700:
Risks to Aquatic Organisms from Use of Chlorpyrifos in the United States
3708: 3648: 2659: 2401:"EPA Will Ban A Farming Pesticide Linked To Health Problems In Children" 792: 11759: 11511: 11476: 11405: 11192: 11067: 11027: 10896: 10857: 10810: 10806: 10538: 10528: 10523: 10436: 10411: 10371: 10366: 10356: 10341: 10282: 10277: 10088: 9948: 9933: 9903: 9878: 9853: 9808: 9803: 9793: 9763: 9733: 9597: 9587: 9532: 9527: 9498: 9475: 9441: 9406: 9391: 9356: 9331: 9185: 9024: 9004: 8935: 8925: 8915: 8905: 8885: 8865: 8796: 8786: 8753: 8748: 8728: 8713: 8703: 8678: 8668: 8663: 8650: 8600: 8570: 8510: 8490: 8475: 8470: 8465: 8445: 8367: 8342: 8332: 8224: 8219: 8171: 8161: 8088: 8035: 8015: 8000: 6030: 5212: 4804: 2909:
Christensen, K.; Harper, B.; Luukinen, B.; Buhl, K.; Stone, D. (2009).
2077:
Lide, David R. (2015โ€“2016). "Physical Constants of Organic Compounds".
1293: 1184: 1138: 1083:, a whistling sound while breathing due to obstruction of the airways. 1003: 986:
and thus is a partial treatment. Pralidoxime is intended to reactivate
474: 232: 7891:"Chlorpyrifos | Banned for use in Malaysia | Health hazards" 6904:"EPA sets limits on the amount of pesticides that may remain in foods" 6323: 5792: 5103: 1587:
under cultivation. No other pesticide has been more thoroughly tested.
97: 11805: 11516: 11448: 11423: 11385: 11350: 11342: 11324: 11309: 11297: 11241: 11218: 11186: 11181: 10971: 10649: 10533: 10482: 10391: 10386: 10376: 10218: 10153: 10148: 10138: 10093: 10063: 10058: 10043: 10028: 9998: 9963: 9953: 9858: 9738: 9728: 9718: 9688: 9683: 9678: 9602: 9577: 9542: 9471: 9446: 9416: 9376: 9326: 9181: 8970: 8965: 8960: 8945: 8844: 8781: 8763: 8580: 8560: 8550: 8530: 8515: 8430: 8405: 8372: 8272: 8166: 8060: 8050: 7995: 7982: 6374:"E.P.A., Citing Risks to Children, Signs Accord to Limit Insecticide" 3605:. Columbia Center for Children's Environmental Health. Archived from 1766: 1554: 1200: 1168: 500: 7417:"Chemicals Considered or Listed Under Proposition 65 - Chlorpyrifos" 4942:"A Strong Case Against a Pesticide Does Not Faze E.P.A. Under Trump" 4751: 1125: 910:
classifies chlorpyrifos as Class II: moderately hazardous. The oral
890:
follow acute poisoning or from long-term exposure to low doses, and
638:
Except where otherwise noted, data are given for materials in their
11780: 11370: 11319: 11175: 11115: 10943: 10913: 10816: 10518: 10451: 10406: 10336: 10304: 10203: 10183: 10173: 10038: 9958: 9888: 9873: 9758: 9753: 9658: 9592: 9537: 9461: 9411: 9341: 9321: 9140: 9042: 9037: 9009: 8984: 8940: 8920: 8625: 8610: 8500: 8485: 8440: 8390: 8327: 8108: 8065: 8045: 8010: 7990: 6901: 5494: 2746: 2150: 1921: 1830: 1550: 1301: 1230: 1068: 1064: 1063:
dysfunctions. In the experiments where embryos did survive, spinal
963: 280: 6466:"Pesticide Action Network v. U.S. Environmental Protection Agency" 5957: 5741:"Ban on domestic sale of insecticide welcomed by fisheries groups" 4380:. Proceedings of the IX International Meeting on Cholinesterases. 2048: 1761:
EPCRA designates the chemicals that facilities must report to the
1091:
Autoantibodies were directed toward smooth muscle, parietal cell,
180: 11236: 10953: 10923: 10553: 10461: 10426: 10198: 10098: 10068: 10053: 10003: 9898: 9843: 9838: 9833: 9828: 9823: 9818: 9813: 9788: 9743: 9637: 9632: 9552: 9547: 9421: 8978: 8870: 8821: 8615: 8605: 8585: 8575: 8535: 8460: 8352: 8322: 7661: 7588:"Dow AgroSciences agrees to pay $ 2M to state over pesticide ads" 7267:"EPA Settlement Creates Pesticide-Free Zones For Salmon โ€“ Law360" 6593: 5307:
International Journal of Environmental Research and Public Health
5149:
International Journal of Environmental Research and Public Health
3875: 2986: 1719: 1613:
to infant and children's health and development is unambiguous."
1482: 1146: 1050: 895: 813: 508: 292: 6207:"Changes to authorisations for products containing chlorpyrifos" 5541:(Report). Pesticide Action Network North America. Archived from 3815: 2619:
Grube, Arthur; Donaldson, David; Kiely, Timothy; Wu, La (2011).
2015:
Agrochemicals: Composition, Production, Toxicology, Applications
1526:(ESA); the Federal Insecticide, Fungicide, and Rodenticide Act ( 11380: 11338: 10908: 10078: 9868: 9627: 9622: 9617: 9612: 9426: 9200: 8590: 8480: 8347: 8337: 8257: 8055: 7042: 7040: 7038: 3549: 1730: 1715: 1538:); and the Emergency Planning and Community Right-to-Know Act ( 1535: 1154: 1142: 1080: 806: 212: 88: 7824:"PRD Live - 27 เด•เต€เดŸเดจเดพเดถเดฟเดจเดฟเด•เดณเตเดŸเต† เดจเดฟเดฐเต‹เดงเดจเดคเตเดคเต† เดชเดฟเดจเตเดคเตเดฃเดšเตเดšเต เดธเด‚เดธเตเดฅเดพเดจเด‚" 6994: 5534:
Kegley, Susan; Tupper, Karl; Wangand, Andrew (December 2006).
3492:(Third ed.). New York: Academic Press. pp. 837โ€“846. 2591:"Interim Reregistration Eligibility Decision for Chlorpyrifos" 1928:
will be fined one million baht, jailed for 10 years, or both.
1868:
Chlorpyrifos was never approved for use in Denmark, except on
1465:
state that chlorpyrifos meets the four criteria (persistence,
11334: 10986: 10456: 10178: 10168: 10018: 9913: 9263: 8545: 8362: 6672:"Deregulation and the Assault on Science and the Environment" 5566: 2908: 1815:
added chlorpyrifos to the list of targeted reductions in the
1539: 1531: 1527: 1507: 1167:
suggest that exposure to low doses of chlorpyrifos may alter
967: 802: 192: 170: 11953: 9608:
Octamethylene-bis(5-dimethylcarbamoxyisoquinolinium bromide)
7035: 6238:
Journal of Exposure Science & Environmental Epidemiology
5695: 5300: 3937: 2314:"NGOs call on Health Canada to expedite ban on chlorpyrifos" 2135: 1153:, chlorpyrifos leads to a build-up of acetylcholine between 342: 10721: 10634: 9654:
2-Ethoxycarbonyl-1-methylvinyl cyclohexyl methylphosphonate
9047: 8317: 7935:
CDC โ€“ NIOSH Pocket Guide to Chemical Hazards โ€“ Chlorpyrifos
7666:
The Australian Pesticides and Veterinary Medicine Authority
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Norรฉn, Erika; Lindh, Christian; et al. (1 July 2020).
5569:"Airborne Poisons: Pesticides in Our Air and in Our Bodies" 5193: 4867:. Role of Prenatal Drugs of Abuse on Neuronal Development. 4494: 3630: 1543: 1511: 1334: 1297: 847: 809:, and fruit trees, including oranges, bananas, and apples. 625: 495: 271: 10690: 7921:(archived version) โ€“ National Pesticide Information Center 7838:"First step towards reassessing controversial insecticide" 7642:. Australian Pesticides and Veterinary Medicines Authority 7616:. Australian Pesticides and Veterinary Medicines Authority 6645:"Trump admin appeals ruling ordering EPA to ban pesticide" 5660:
Airborne Poisons: Pesticides in Our Air, and in Our Bodies
5251: 5201:
Journal of Exposure Science and Environmental Epidemiology
4976:"Chlorpyrifos Revised Human Health Risk Assessment (2016)" 4113:
American Journal of Respiratory and Critical Care Medicine
4109: 3690: 3250: 2734: 2239:"Common Insecticide May Harm Boys' Brains More Than Girls" 2081:(96 ed.). Boca Raton, FL: CRC Press. pp. 3โ€“122. 1829:
California included regulation limits for chlorpyrifos in
1751:
U.S. District Court for the Western District of Washington
1670:
The use of chlorpyrifos in agriculture can leave chemical
923:
Acute poisoning results mainly from interference with the
11231: 8312: 7461:"The end in sight for a perilous pesticide in California" 7387:"Water Quality Total Maximum Daily Loads (TMDLs) Program" 7049:"Section 180.342 โ€“ Chlorpyrifos; tolerances for residues" 6997:"Proposal to Revoke Chlorpyrifos Food Residue Tolerances" 5628:"Douglas Fischer, "Toxins permeate Central Valley town", 5403: 4559: 3045: 2850: 2218: 1515: 1503: 7245:"ODA Pesticides Interim court ordered pesticide buffers" 6589:"U.S. EPA denies petition to ban pesticide chlorpyrifos" 6487: 6485: 6324:
U.S. EPA, Office of Pesticide Programs (February 2002).
5142: 4861: 4749: 4681: 4436: 4226: 1945:
Chlorpyrifos is produced via a multistep synthesis from
1469:, long-range transport, and toxicity) in Annex D of the 6231: 5887: 5634:. Origin.insidebayarea.com. 16 May 2007. Archived from 4969: 4967: 4965: 4963: 4371: 3198: 3167: 7734:. European Food Safety Authority Journal. 31 July 2019 7640:
Public Chemical Registration Information System Search
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US EPA Office of Pesticide Programs (20 August 2015).
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Sanchez-Bayo, Francisco; Goka, Koichi (9 April 2014).
5476: 3686: 3684: 3383:"Thai experts: Bed bug spray didn't kill Kiwi tourist" 2791: 990:, but the benefit of oxime treatment is questioned. A 6670:
Samet, Jonathan M.; Burke, Thomas A. (2 April 2020).
6482: 6146:"Prohibition on the use of chlorpyrifos in Singapore" 4935: 4933: 4931: 2699: 2618: 2283:"EU-Wide ban of Chlorpyrifos and Chlorpyrifos-methyl" 2055:
National Institute for Occupational Safety and Health
1652:
United States Court of Appeals for the Eighth Circuit
1471:
Stockholm Convention on Persistent Organic Pollutants
1071:, another commonly used organophosphate insecticide. 731:
Stockholm Convention on Persistent Organic Pollutants
6881:"EPA Continues Work to Reduce Chlorpyrifos Exposure" 5768:"Domestic source 'likely' cause of Kennet pollution" 4960: 3334:"Sarah Carter's likely cause of death โ€“ insecticide" 2530: 2257:"UK to ban sales and use of chlorpyrifos from April" 11713:
2024 United Kingdom Shigatoxigenic E. coli outbreak
6616:"Federal appeals court orders EPA to ban pesticide" 6541:
EPA Urged to Ban Widely-Used Pesticide Chlorpyrifos
5824: 5822: 5533: 5085: 5028: 4177: 3681: 3097: 2855:(Report). World Health Organization. Archived from 2131: 2129: 1872:grown in greenhouses. This use was banned in 2012. 7861: 7511:"Hawaii to ban pesticides containing chlorpyrifos" 7172:"New Limits on Pesticide Uses Will Protect Salmon" 6781:Lipton, Eric; Rabin, Roni Caryn (18 August 2017). 5953: 5951: 4928: 4624: 2904: 2902: 2900: 2898: 2896: 2728: 1120: 533:160 ยฐC; 320 ยฐF; 433 K (decomposes) 9218: 6581: 5831:"Pesticide Residues and Bees โ€“ A Risk Assessment" 3809: 3750: 12021: 6008: 5828: 5819: 5743:. FishUpdate.com. 28 August 2013. Archived from 4049: 3483: 3481: 3479: 3477: 2930: 2928: 2126: 1161: 304: 6725: 6723: 6182:"Harmful pesticide banned in SA โ€“ South Africa" 5948: 5691: 5689: 4265:12th Ed. British Crop Protection Council (BCPC) 2893: 2490: 2451:April 20; Sass, 2022 Jennifer (20 April 2022). 2100: 2098: 2008: 2006: 1333:Acute exposure to chlorpyrifos can be toxic to 1187:system; and influence other chemical pathways. 156: 126:-(3,5,6-trichloropyridin-2-yl) phosphorothioate 10563:Many of the other AChE inhibitors listed above 7969: 7339:"OSHA PEL Project Documentation: Chlorpyrifos" 7151:"Hazardous Substances Data Bank: Chlorpyrifos" 4316: 4314: 4155:"Lung Cancer in the Agricultural Health Study" 3980: 3978: 3933: 3931: 3929: 3487: 3433: 3431: 3429: 3380: 3312:"Toxin 'likely' cause of Sarah Carter's death" 3163: 3161: 2982: 2980: 1722:in any solution or mixture. EPA has not set a 1141:, chlorpyrifos-oxon, binds permanently to the 941: 10873: 10503: 9167: 7955: 7915:, National Pesticide Information Center (PDF) 7292:NIH U.S National Library of Medicine WebWISER 6509: 6296:"Summary of the Toxic Substances Control Act" 6209:. Health and Safety Executive. Archived from 3474: 2925: 2012: 1530:); the Federal Food, Drug, and Cosmetic Act ( 1406:The examples and perspective in this section 918: 29:The examples and perspective in this article 11888:Spanish Agency for Food Safety and Nutrition 11703:2017โ€“2018 South African listeriosis outbreak 11602:1985 Austrian diethylene glycol wine scandal 10842:Muscarinic acetylcholine receptor modulators 9299: 7864:"Farmers given 90 days to hand in chemicals" 7802:International Campaign for Justice in Bhopal 6720: 6639: 6637: 5793:Washington State Department of Agriculture. 5686: 4490: 4488: 4486: 4484: 2450: 2095: 2003: 1902:Food Safety and Standards Authority of India 1813:Oregon's Department of Environmental Quality 778: 11826:United Kingdom food information regulations 10847:Nicotinic acetylcholine receptor modulators 10726:Tooltip Vesicle-associated membrane protein 10639:Tooltip Vesicular acetylcholine transporter 10593: 7047:Code of Federal Regulations (1 July 2010). 6928: 6926: 6924: 6922: 6920: 6780: 4311: 3975: 3926: 3426: 3172:(2). John Wiley & Sons, Ltd: CD005085. 3158: 2977: 2476:: CS1 maint: numeric names: authors list ( 1592:Statement Dow AgroSciences October 30, 2015 10880: 10866: 10695:Tooltip Synaptosomal-associated protein 25 9174: 9160: 7962: 7948: 7773:"Dow AgroSciences Blacklisted for Bribing" 7429: 7391:Oregon Department of Environmental Quality 7144: 7142: 6669: 6544:, Environment News Service, 5 January 2016 4904: 4902: 4745: 4743: 4365: 2515: 2365: 2363: 1424:, or create a new section, as appropriate. 749:The industrial synthesis of chlorpyrifos ( 701:inhibiting the acetylcholinesterase enzyme 357: 262: 240: 11664:2008 United States salmonellosis outbreak 7754:"เดตเดฟเดทเดคเตเดคเดฟเตฝ เดฎเตเด™เตเด™เดฟเด•เตเด•เตเดณเดฟเดšเตเดšเต เดฎเตเดณเด•เตเด‚ เดšเต€เดฐเดฏเตเด‚" 6687: 6634: 6532: 6405: 6267: 6249: 6046: 5985: 5975: 5931: 5913: 5864: 5854: 5510: 5429: 5328: 5318: 5269: 5228: 5170: 5160: 5119: 5062: 4838: 4723: 4658: 4601: 4536: 4481: 4430: 4413: 4268: 4195: 4026: 3858: 3792: 3724: 3664: 3525:"Chlorpyrifos | Pesticide Action Network" 3287: 3269: 3141: 3123: 3022: 3004: 2952: 2934: 2827: 2817: 2336: 2334: 2166: 2076: 1498:Pesticide regulation in the United States 1440:Learn how and when to remove this message 1115: 324: 67:Learn how and when to remove this message 11708:2018 Australian strawberry contamination 11570:Morinaga Milk arsenic poisoning incident 10887: 7363: 6917: 6851: 6689:10.1146/annurev-publhealth-040119-094056 6436: 6345: 6293: 4908: 4184:Journal of the National Cancer Institute 2588: 2343:"US bans chlorpyrifos on all food crops" 2275: 2249: 2049:NIOSH Pocket Guide to Chemical Hazards. 1779: 1679:residues onto crops without tolerances. 1553:control. It may also be sold in ant and 1263:Air monitoring studies conducted by the 1124: 1103:The Dow Chemical Company also developed 791: 11678:2011 United States listeriosis outbreak 9799:Dimethyl 4-(methylthio)phenyl phosphate 7707:"Search | The National Law Review" 7678: 7158:U.S National Library of Medicine TOXNET 7139: 6835:"What is the Insecticide Chlorpyrifos?" 6439:"Chlorpyrifos returns to the US market" 6072:"Chlorpyrifos as a possible global POP" 4899: 4740: 4320: 3984: 3490:Hayes' Handbook of Pesticide Toxicology 3437: 3170:Cochrane Database of Systematic Reviews 2913:. National Pesticide Information Center 2394: 2392: 2369: 2360: 2311: 2305: 2111:Insecticide Resistance Action Committee 1476: 1190: 901: 898:and children even at very small doses. 703:. Chlorpyrifos was patented in 1966 by 353: 12022: 11693:2015 Mozambique funeral beer poisoning 11270:Ethylenediaminetetraacetic acid (EDTA) 7537:"New Hawaii law bans use of pesticide" 7019: 6814: 6663: 6437:Erickson, Britt E. (6 November 2023). 6432: 6430: 6428: 6371: 5599: 5379:"CARB Chlorpyrifos Monitoring Studies" 3881: 3553:Regulatory Toxicology and Pharmacology 2418: 2340: 2331: 2236: 2044: 2042: 2040: 2038: 2036: 2034: 1784:In 1989, OSHA established a workplace 1563:Pesticide Action Network North America 1282: 1098: 861: 846:. They also found it to enter through 253: 10861: 9989:Methylfluorophosphonylcholine (MFPCh) 9239:2-(ฮฑ-Naphthoyl)ethyltrimethylammonium 9155: 7943: 7770: 7458: 7311: 6069: 5795:"Bee Kill Prevention for Tree Fruits" 5351: 5024: 5022: 4939: 4274: 3746: 3744: 3519: 3517: 2584: 2582: 2580: 2561:. Pestmanagement.info. Archived from 2559:"NASS Agricultural Chemical Database" 2453:"EPA Bans Chlorpyrifos On Food Crops" 2232: 2230: 2143:Pesticide Biochemistry and Physiology 1215: 952:National Pesticide Information Center 523:43 ยฐC (109 ยฐF; 316 K) 385:Key: SBPBAQFWLVIOKP-UHFFFAOYSA-N 220: 200: 11984: 11872:Institute for Food Safety and Health 11612:Australian meat substitution scandal 11580:Moroccan oil poisoning disaster 1959 11356:Arsenic contamination of groundwater 7679:Hecklen, Alexander (6 August 2019). 7264: 6995:US Environmental Protection Agency. 6521:, Dow AgroSciences, 10 November 2016 6143: 5765: 5658:"Californians For Pesticide Reform, 4255: 3408:"Thais deny tourists' deaths linked" 2398: 2389: 2223:(Report). World Health Organization. 1792:and no PELs are in place presently. 1601:On 29 March 2017, EPA Administrator 1452: 1392: 1356: 1292:Among freshwater aquatic organisms, 783:Industrial synthesis of chlorpyrifos 15: 12004: 11860:Food Information and Control Agency 10786: 9289:N,N-Dimethylaminoethylchloroacetate 7771:Kumar, Devesh (18 September 2010). 7478: 7148: 6425: 6406:Beckerman, Josh (31 October 2015). 6019:The Journal of Experimental Biology 5600:Hansen, Heather (18 January 2007). 5567:Californians for Pesticide Reform. 4323:Toxicology and Applied Pharmacology 3953:10.1016/j.pediatrneurol.2007.10.009 3364:"Thailand death cover-up suspected" 2911:"Chlorpyrifos Technical Fact Sheet" 2738:Journal of Environmental Management 2070: 2031: 2017:. Toronto: Wiley-VCH. p. 541. 1822:In 2017, chlorpyrifos was included 1712:Federal Water Pollution Control Act 1315:(2001), Wey (2002 & 2003), and 395:Key: SBPBAQFWLVIOKP-UHFFFAOYAG 295: 279: 13: 7862:APINYA WIPATAYOTIN (29 May 2020). 7842:Environmental Protection Authority 7288:"Chlorpyrifos โ€“ CERCLA Quantities" 7020:Lerner, Sharon (14 January 2017). 5019: 4643:10.1016/j.brainresbull.2013.10.014 3741: 3514: 3498:10.1016/B978-0-12-374367-1.00033-1 2851:World Health Organization (2010). 2577: 2533:"Chlorpyrifos and Responsible Use" 2509: 2341:Trager, Rebecca (27 August 2021). 2227: 2219:World Health Organization (2019). 1724:drinking water regulatory standard 1183:enzymes; affect components of the 882:Chlorpyrifos exposure may lead to 821:agriculture in the United States. 464: 416:Clc1c(OP(=S)(OCC)OCC)nc(Cl)c(Cl)c1 14: 12071: 11877:International Food Safety Network 11801:International Food Safety Network 11522:Variant Creutzfeldtโ€“Jakob disease 11472:Acid-hydrolyzed vegetable protein 11199:Shigatoxigenic and verotoxigenic 9223:Tooltip Choline acetyltransferase 7919:Chlorpyrifos Technical Fact Sheet 7913:CHLORPYRIFOS โ€“ GENERAL FACT SHEET 7901: 6372:Revkin, Andrew C. (9 June 2000). 6144:Yong, Koh Chin (1 January 2009). 5483:Environmental Health Perspectives 5410:Environmental Health Perspectives 5092:Environmental Health Perspectives 5035:Environmental Health Perspectives 4940:Rabin, Roni Caryn (16 May 2017). 3697:Environmental Health Perspectives 3637:Environmental Health Perspectives 2935:Eddleston, M. (1 November 2000). 2430:Beyond Pesticides Daily News Blog 2312:Meshkat, Nazanin (26 July 2021). 2079:Handbook of Chemistry and Physics 1888:chlorpyrifos is clearly a potent 1875: 1739:National Marine Fisheries Service 1650:However, on November 2, 2023 the 1567:Natural Resources Defense Council 1237: 997: 877: 770:-diethyl phosphorochloridothioate 735:Natural Resources Defense Council 12003: 11993: 11983: 11974: 11973: 11962: 11952: 11882:Ministry of Food and Drug Safety 11718:Kobayashi red yeast rice scandal 11649:2008 Canada listeriosis outbreak 11644:ICA meat repackaging controversy 10283:Fasciculins (green mamba toxins) 9774:Dicyclohexyl phosphorofluoridate 7883: 7855: 7830: 7816: 7790: 7764: 7746: 7717: 7699: 7672: 7654: 7628: 7606: 7580: 7555: 7529: 7503: 7452: 7423: 7409: 7379: 7357: 7331: 7312:Fried, John J. (20 March 1996). 7305: 7280: 7258: 7237: 7211: 7186: 7164: 7113: 7083: 7062: 7013: 6988: 6958: 6895: 6873: 6843:. 10 August 2018. 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One chlorpyrifos 646: 455: 449: 443: 96: 87: 20: 12030:Acetylcholinesterase inhibitors 11821:Quality Assurance International 11728:Food safety incidents in Taiwan 11698:2017 Brazil Operation Weak Meat 11592:1971 Iraq poison grain disaster 11507:Polycyclic aromatic hydrocarbon 10214:Tetraethyl pyrophosphate (TEPP) 9939:Hexaethyl tetraphosphate (HETP) 7908:Chlorpyrifos General Fact Sheet 7636:"APVMA PubCRIS database search" 7563:"New Requirements Under Act 45" 6444:Chemical & Engineering News 5881: 5786: 5766:Case, Philip (1 October 2013). 5759: 5733: 5650: 5620: 5593: 5560: 5527: 5470: 5446: 5397: 5371: 5345: 5294: 5245: 5187: 5136: 5079: 4994: 4855: 4798: 4756:Chemico-Biological Interactions 4675: 4618: 4553: 4378:Chemico-Biological Interactions 4220: 4171: 4147: 4103: 4043: 3624: 3587: 3543: 3400: 3374: 3356: 3326: 3304: 3244: 3192: 3091: 3039: 2871: 2844: 2785: 2693: 2669: 2645: 2612: 2551: 2524: 2495:. William Andrew. p. 313. 2484: 2444: 1747:Fourth Circuit Court of Appeals 1729:In 2009, to protect threatened 1656:Environmental Protection Agency 1287: 1151:inhibiting acetylcholinesterase 1121:Acetylcholine neurotransmission 935:suffocation from lung failure. 930:pathway, leading to a range of 872:acetylcholinesterase inhibition 642:(at 25 ยฐC , 100 kPa). 12050:Suspected endocrine disruptors 11850:European Food Safety Authority 11723:Food safety incidents in China 11560:1858 Bradford sweets poisoning 11527:Water fluoridation controversy 9284:N,N-Dimethylaminoethylacrylate 7662:"Chlorpyrifos Chemical Review" 6939:(Report). 2006. Archived from 6815:Lipton, Eric (9 August 2018). 6676:Annual Review of Public Health 5258:Annals of Occupational Hygiene 4688:Neurotoxicology and Teratology 4566:Neurotoxicology and Teratology 4443:Critical Reviews in Toxicology 4053:Neurotoxicology and Teratology 4011:10.1016/j.reprotox.2010.07.012 3381:Hayden Donnell (11 May 2011). 3178:10.1002/14651858.CD005085.pub2 2212: 2199: 2061: 1971: 1940: 1907: 1890:acetylcholinesterase inhibitor 1885:European Food Safety Authority 1610:American Academy of Pediatrics 1571:Ninth Circuit Court of Appeals 1265:California Air Resources Board 1129:Structure of chlorpyrifos-oxon 1024:detoxify chlorpyrifos and its 1018: 824: 570:Occupational safety and health 467: 458: 437: 1: 10837:Receptor/signaling modulators 10609:Hemicholinium-3 (hemicholine) 10508:Tooltip Butyrylcholinesterase 7459:Elias, Tom (27 August 2019). 7364:U.S. EPA (22 February 2005). 6294:U.S. EPA (22 February 2013). 5381:. Cdpr.ca.gov. Archived from 4877:10.1016/S0165-3806(03)00222-0 4241:10.1080/00039896.1993.9938400 3985:Slotkin, T. A. (April 2011). 3214:10.1016/S0140-6736(06)69862-0 3061:10.1016/S0140-6736(05)67598-8 2763:10.1016/j.jenvman.2012.10.032 2722:10.1016/S0003-2670(97)00680-6 2289:. August 2020. Archived from 1964: 1803: 1790:U.S. Circuit Court of Appeals 1352: 1162:Non-cholinesterase mechanisms 593:(US health exposure limits): 12035:Organophosphate insecticides 11855:Food and Drug Administration 11537:Food contamination incidents 9304:Tooltip Acetylcholinesterase 6974:Food and Drug Administration 5915:10.1371/journal.pone.0077547 5856:10.1371/journal.pone.0094482 5354:"Chlorpyrifos Status Update" 4865:Developmental Brain Research 4125:10.1164/ajrccm.165.5.2106074 3777:10.1016/j.envint.2017.05.015 3452:10.1016/j.toxlet.2011.11.026 3271:10.1371/journal.pmed.1000104 2653:"Dursban Pro specimen label" 2493:Pesticide Synthesis Handbook 2168:10.1016/j.pestbp.2020.104587 1847: 1756: 1074: 1013: 957: 744: 7: 11909:Food and drink prohibitions 11683:Bihar school meal poisoning 11607:United Kingdom BSE outbreak 11565:1900 English beer poisoning 10919:Antibiotic use in livestock 10598:Tooltip Choline transporter 10544:Profenamine (ethopropazine) 9784:Diisopropyl fluorophosphate 9249:4-(1-Naphthylvinyl)pyridine 9234:1-(-Benzoylethyl)pyridinium 8456:Diisopropyl fluorophosphate 7687:(in Danish). Danmarks Radio 7430:California (11 July 2013). 7095:Code of Federal Regulations 6840:National Geographic Society 6563:"The Facts on Chlorpyrifos" 6153:National Environment Agency 5709:10.1007/978-3-319-03865-0_5 3904:10.1016/j.neuro.2004.07.007 3843:10.1016/j.neuro.2013.09.003 3565:10.1016/j.yrtph.2013.10.005 2013:Muller, Franz, ed. (2000). 1952: 1931: 1915: 1824:California's Proposition 65 1737:under CWA and ESA, EPA and 1420:, discuss the issue on the 992:randomized controlled trial 942:Frequency of acute exposure 833: 755:3,5,6-trichloro-2-pyridinol 43:, discuss the issue on the 10: 12076: 12040:Organothiophosphate esters 11904:Curing (food preservation) 10977:Monosodium glutamate (MSG) 10447:Dimethylcarbamoyl fluoride 9254:Acetylseco hemicholinium-3 6303:(Overviews and Factsheets) 5606:Seattle Post-Intelligencer 4811:Behavioural Brain Research 4445:. 38 Suppl 2 (s2): 1โ€“125. 4343:10.1016/j.taap.2003.06.001 2626:. U.S. EPA. Archived from 2531:The Dow Chemical Company. 2137:Wessels, Frank J. (2020). 1863: 1797:Worker Protection Standard 1786:permissible exposure limit 1665: 1619:Freedom of Information Act 1495: 1329:Pesticide toxicity to bees 1326: 1177:neuropathy target esterase 962:Poisoning is treated with 919:Symptoms of acute exposure 868:organophosphate pesticides 741:of North America (PANNA). 619:TWA 0.2 mg/m ST 0.6 mg/m 513:1.398 g/cm (43.5 ยฐC) 11947: 11934:Genetically modified food 11896: 11834: 11786:Food labeling regulations 11758: 11654:2008 Chinese milk scandal 11535: 11457: 11404: 11333: 11283: 11255: 11217: 11106: 11014: 10962: 10895: 10829: 10775: 10679: 10662: 10632: 10591: 10574: 10501: 9297: 9216: 9199: 9135:Purpureocillium lilacinum 9056: 9023: 8858: 8820: 8649: 8381: 8248: 8185: 8137: 8094:Chromated copper arsenate 8074: 8026:m-Cumenyl methylcarbamate 7981: 6346:U.S. EPA (27 June 2001). 6251:10.1038/s41370-020-0212-8 4909:U.S. EPA (30 June 2011). 4823:10.1016/j.bbr.2009.08.006 4776:10.1016/j.cbi.2010.01.024 4708:10.1016/j.ntt.2013.10.004 4586:10.1016/j.ntt.2013.02.002 4521:10.1016/j.tox.2012.07.011 4451:10.1080/10408440802272158 4398:10.1016/j.cbi.2008.04.008 4289:10.1016/j.cca.2005.10.008 4073:10.1016/j.ntt.2018.10.001 3757:Environment International 1959:Organophosphate poisoning 1855:emulsifiable concentrates 1370:This section needs to be 1006:, Thailand who developed 908:World Health Organization 888:Persistent health effects 712:World Health Organization 693:organophosphate pesticide 636: 587: 567: 562: 424: 404: 369: 140: 132: 109: 104: 95: 86: 11796:Food safety in Australia 10992:High-fructose corn syrup 10317:Methanesulfonyl fluoride 8139:Insect growth regulators 7444:: CS1 maint: location ( 7070:"Chlorpyrifos โ€“ PubChem" 6859:"Chlorpyriphos l US EPA" 5977:10.3389/fphys.2013.00013 2677:"Strike-Out 500WP label" 2491:Thomas A. Unger (1996). 1895: 1771:National Response Center 1763:Toxics Release Inventory 1705: 1580:Environment News Service 966:and simultaneously with 739:Pesticide Action Network 12055:Suspected fetotoxicants 11776:Acceptable daily intake 11688:2013 horse meat scandal 11129:Clostridium perfringens 9494:+glycopyrronium bromide 9128:Paenibacillus popilliae 7930:EPA's Chlorpyrifos Page 7223:Bergeson & Campbell 7149:GCF (10 January 2008). 5964:Frontiers in Physiology 5162:10.3390/ijerph110403743 4631:Brain Research Bulletin 3991:Reproductive Toxicology 3006:10.1186/1471-2458-7-357 2954:10.1093/qjmed/93.11.715 2819:10.1073/pnas.1203396109 2518:San Francisco Chronicle 1322: 906:For acute effects, the 787: 11844:Centre for Food Safety 11659:2008 Irish pork crisis 11361:Benzene in soft drinks 9244:3-Chloro-4-stillbazole 9107:Metarhizium anisopliae 9086:Beauveria brongniartii 9067:Bacillus thuringiensis 8119:Lead hydrogen arsenate 7592:Albany Business Review 7314:"The Pesticide Puzzle" 6070:Watts, Meriel (2012). 6009:Williamson, Sally M.; 3387:The New Zealand Herald 3125:10.1186/1476-069X-8-18 2881:. Pmep.cce.cornell.edu 2702:Analytica Chimica Acta 1595: 1524:Endangered Species Act 1130: 1116:Mechanisms of toxicity 797: 784: 753:) is made by reacting 11866:Food Standards Agency 11816:Organic certification 11811:Nutrition facts label 11555:Esing Bakery incident 11343:environment pollution 9121:Lecanicillium lecanii 7154:(Reference Resources) 5422:10.1289/ehp.021101175 5320:10.3390/ijerph8051727 5271:10.1093/annhyg/mel062 2207:U.S. patent 3,244,586 1780:Occupational exposure 1584: 1245:acceptable daily dose 1128: 870:chlorpyrifos acts by 795: 782: 558:4.96 (octanol/water) 11635:2006 North American 11293:Acesulfame potassium 11122:Campylobacter jejuni 11016:Intestinal parasites 10889:Consumer food safety 10805:Atracotoxins (e.g., 10432:Tetrahydrocannabinol 9779:Diisopropylphosphate 8268:Carbon tetrachloride 7711:www.natlawreview.com 6326:"Chlorpyrifos Facts" 6011:Wright, Geraldine A. 5352:Vogel, Dana (2016). 5047:10.1289/ehp.02110549 4277:Clinica Chimica Acta 4263:The Pesticide Manual 3344:on 14 September 2011 3104:Environmental Health 2565:on 27 September 2011 1477:National regulations 1418:improve this section 1408:may not represent a 1191:Paraoxonase activity 988:acetylcholinesterase 980:muscarinic receptors 902:Acute health effects 716:autoimmune disorders 705:Dow Chemical Company 111:Preferred IUPAC name 49:create a new article 41:improve this article 31:may not represent a 11939:Conspiracy theories 11492:Heterocyclic amines 11396:Shellfish poisoning 10791:Tooltip Latrophilin 10493:Trimedoxime bromide 10422:Stercuronium iodide 10239:Tricresyl phosphate 9714:Chlorpyrifos-methyl 9100:Metarhizium acridum 8830:Chlorantraniliprole 8426:Chlorpyrifos-methyl 8099:Copper(II) arsenate 8084:Aluminium phosphide 8076:Inorganic compounds 7893:. 19 February 2024. 7465:Ventura County Star 7174:. 11 September 2009 6651:. 24 September 2018 6620:Washington Examiner 6412:Wall Street Journal 5906:2014PLoSO...977547Z 5847:2014PLoSO...994482S 4768:2010CBI...184..449L 4700:2014NTxT...41...35L 4578:2013NTxT...37....1S 4513:2013Toxgy.307..115C 4390:2008CBI...175..355C 4335:2004ToxAP.198..132S 4197:10.1093/jnci/djh324 4167:on 15 October 2011. 4065:2018NTxT...70...18C 4003:2011RepTx..31..297S 3941:Pediatric Neurology 3896:2005NeuTx..26..573P 3835:2013NeuTx..39..158M 3769:2017EnInt.106..248S 3709:10.1289/ehp.1003160 3649:10.1289/ehp.1003185 3531:. 11 September 2015 3208:(9553): 2136โ€“2141. 3116:2009EnvHe...8...18S 3055:(9495): 1452โ€“1459. 2810:2012PNAS..109.7871R 2755:2013JEnvM.114..372C 2714:1998AcAC..360....1S 2600:on 19 November 2012 2287:Eurofins Scientific 2243:Scientific American 2159:2020PBioP.16704587S 2114:. 16 September 2020 1283:Effects on wildlife 1273:Lindsay, California 1175:enzymes, including 1105:Chlorpyrifos methyl 1099:Chlorpyrifos methyl 984:nicotinic receptors 862:Mechanism of action 540:Solubility in water 490:Colorless crystals 482: gยทmol 83: 11597:Toxic oil syndrome 11550:Swill milk scandal 11376:Diethylstilbestrol 11048:Diphyllobothriasis 10310:Onchidella binneyi 9652:Organophosphates: 9093:Isaria fumosorosea 9079:Beauveria bassiana 8975:Piperonyl butoxide 8776:chrysanthemic acid 8114:Diatomaceous earth 7777:The Economic Times 7594:. 15 December 2003 7225:. 25 February 2013 6883:. 14 December 2022 6861:. 29 December 2014 6847:on 11 August 2018. 6821:The New York Times 6787:The New York Times 6378:The New York Times 6031:10.1242/jeb.083931 5807:on 30 October 2014 5213:10.1038/jes.2009.6 5006:toxnet.nlm.nih.gov 4946:The New York Times 4439:Mobley, William C. 4261:Tomlin CDS (2000) 3612:on 2 February 2016 3440:Toxicology Letters 2665:on 24 August 2009. 2318:The Globe and Mail 1677:drift of pesticide 1225:, a treatment for 1216:Combined exposures 1149:. By irreversibly 1131: 1047:Animal experiments 978:from binding with 974:. Atropine blocks 894:effects appear in 856:respiratory system 798: 785: 689:chlorpyrifos ethyl 669:Infobox references 628:(Immediate danger) 81: 12017: 12016: 11924:Food preservation 11733:Foodborne illness 11285:Sugar substitutes 11038:Cryptosporidiosis 11020:parasitic disease 10934:HGH controversies 10901:food contaminants 10855: 10854: 10825: 10824: 10673: 10658: 10657: 10585: 10570: 10569: 10209:Tetrachlorvinphos 10084:Pirimiphos-methyl 10034:Oxydemeton-methyl 9984:Methyl phenkapton 9210: 9149: 9148: 8950:+milbemycin oxime 8631:Tetrachlorvinphos 8596:Pirimiphos-methyl 8556:Oxydemeton-methyl 8104:Copper(I) cyanide 7397:on 21 August 2014 6735:Los Angeles Times 6497:, 6 November 2015 6305:on 21 August 2014 6162:on 21 August 2014 6132:Directive 98/8/EC 6088:on 22 August 2014 6025:(10): 1799โ€“1807. 5774:on 10 August 2014 5718:978-3-319-03864-3 5662:, May 16th, 2007" 5638:on 8 January 2016 5632:, May 15th, 2007" 5630:Tri-Valley Herald 5548:on 10 August 2014 5466:on 21 April 2006. 5104:10.1289/ehp.10912 4190:(23): 1781โ€“1789. 3507:978-0-12-374367-1 2993:BMC Public Health 2804:(20): 7871โ€“7876. 2689:on 11 March 2011. 2589:U.S. EPA (2002). 2024:978-3-527-29852-5 1991:on 1 January 2019 1870:ornamental plants 1453:International law 1450: 1449: 1442: 1391: 1390: 1205:genetic variation 928:neurotransmission 886:at higher doses. 687:), also known as 677:Chemical compound 675: 674: 338:CompTox Dashboard 182:Interactive image 77: 76: 69: 51:, as appropriate. 12067: 12007: 12006: 11997: 11987: 11986: 11977: 11976: 11969:Drink portal 11967: 11966: 11965: 11957: 11956: 11868:(United Kingdom) 11617:Jack in the Box 11588: 11575:Minamata disease 11487:Food irradiation 11467:4-Hydroxynonenal 11315:Sodium cyclamate 11158:Escherichia coli 11150:Escherichia coli 10882: 10875: 10868: 10859: 10858: 10792: 10788: 10727: 10723: 10696: 10692: 10677: 10676: 10667: 10640: 10636: 10599: 10595: 10589: 10588: 10579: 10509: 10505: 10473:Asoxime chloride 10049:Parathion-methyl 9749:Demeton-S-methyl 9305: 9301: 9224: 9220: 9214: 9213: 9204: 9176: 9169: 9162: 9153: 9152: 8835:Cyantraniliprole 8566:Parathion-methyl 8436:Demeton-S-methyl 8383:Organophosphorus 7964: 7957: 7950: 7941: 7940: 7895: 7894: 7887: 7881: 7880: 7878: 7876: 7859: 7853: 7852: 7850: 7848: 7834: 7828: 7827: 7820: 7814: 7813: 7811: 7809: 7804:. 21 August 2007 7794: 7788: 7787: 7785: 7783: 7768: 7762: 7761: 7750: 7744: 7743: 7741: 7739: 7729: 7721: 7715: 7714: 7703: 7697: 7696: 7694: 7692: 7676: 7670: 7669: 7658: 7652: 7651: 7649: 7647: 7632: 7626: 7625: 7623: 7621: 7610: 7604: 7603: 7601: 7599: 7584: 7578: 7577: 7575: 7573: 7559: 7553: 7552: 7550: 7548: 7533: 7527: 7526: 7524: 7522: 7507: 7501: 7500: 7498: 7496: 7482: 7476: 7475: 7473: 7471: 7456: 7450: 7449: 7443: 7435: 7427: 7421: 7420: 7413: 7407: 7406: 7404: 7402: 7393:. 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Archived from 4159: 4151: 4145: 4144: 4107: 4101: 4100: 4047: 4041: 4040: 4030: 3982: 3973: 3972: 3935: 3924: 3923: 3879: 3873: 3872: 3862: 3813: 3807: 3806: 3796: 3748: 3739: 3738: 3728: 3703:(8): 1196โ€“1201. 3688: 3679: 3678: 3668: 3643:(8): 1189โ€“1195. 3628: 3622: 3621: 3619: 3617: 3611: 3600: 3594:Rauh, Virginia. 3591: 3585: 3584: 3547: 3541: 3540: 3538: 3536: 3521: 3512: 3511: 3485: 3472: 3471: 3435: 3424: 3423: 3421: 3419: 3404: 3398: 3397: 3395: 3393: 3378: 3372: 3371: 3368:NZ Herald Online 3360: 3354: 3353: 3351: 3349: 3340:. Archived from 3330: 3324: 3323: 3321: 3319: 3308: 3302: 3301: 3291: 3273: 3248: 3242: 3241: 3196: 3190: 3189: 3165: 3156: 3155: 3145: 3127: 3095: 3089: 3088: 3043: 3037: 3036: 3026: 3008: 2984: 2975: 2974: 2956: 2932: 2923: 2922: 2920: 2918: 2906: 2891: 2890: 2888: 2886: 2875: 2869: 2868: 2866: 2864: 2848: 2842: 2841: 2831: 2821: 2789: 2783: 2782: 2732: 2726: 2725: 2697: 2691: 2690: 2688: 2682:. Archived from 2681: 2673: 2667: 2666: 2664: 2658:. Archived from 2657: 2649: 2643: 2642: 2640: 2638: 2633:on 18 March 2015 2632: 2625: 2616: 2610: 2609: 2607: 2605: 2596:. Archived from 2595: 2586: 2575: 2574: 2572: 2570: 2555: 2549: 2548: 2546: 2544: 2535:. Archived from 2528: 2522: 2521: 2513: 2507: 2506: 2488: 2482: 2481: 2475: 2467: 2465: 2463: 2448: 2442: 2441: 2439: 2437: 2422: 2416: 2415: 2413: 2411: 2396: 2387: 2386: 2384: 2382: 2376:The Conversation 2367: 2358: 2357: 2355: 2353: 2338: 2329: 2328: 2326: 2324: 2309: 2303: 2302: 2300: 2298: 2279: 2273: 2272: 2270: 2268: 2253: 2247: 2246: 2234: 2225: 2224: 2216: 2210: 2209: 2203: 2197: 2196: 2170: 2133: 2124: 2123: 2121: 2119: 2102: 2093: 2092: 2074: 2068: 2065: 2059: 2058: 2046: 2029: 2028: 2010: 2001: 2000: 1998: 1996: 1990: 1984:. Archived from 1983: 1975: 1947:3-methylpyridine 1593: 1445: 1438: 1434: 1431: 1425: 1401: 1400: 1393: 1386: 1383: 1377: 1365: 1364: 1357: 1173:serine hydrolase 1135:neurotransmitter 659: 653: 650: 649: 481: 469: 466: 460: 457: 451: 445: 439: 432:Chemical formula 362: 361: 346: 344: 328: 308: 297: 283: 266: 255: 244: 224: 204: 184: 160: 100: 91: 84: 80: 72: 65: 61: 58: 52: 24: 23: 16: 12075: 12074: 12070: 12069: 12068: 12066: 12065: 12064: 12045:Chloropyridines 12020: 12019: 12018: 12013: 11963: 11961: 11959:Food portal 11951: 11943: 11892: 11830: 11791:Food libel laws 11754: 11582: 11531: 11497:Modified starch 11459:Food processing 11453: 11400: 11329: 11279: 11275:Sodium benzoate 11251: 11213: 11208:Vibrio cholerae 11102: 11073:Gnathostomiasis 11058:Fasciolopsiasis 11010: 10958: 10949:Mercury in fish 10891: 10886: 10856: 10851: 10821: 10790: 10771: 10731:Botulinum toxin 10725: 10700:Botulinum toxin 10694: 10666: 10654: 10638: 10628: 10614:Triethylcholine 10597: 10578: 10566: 10507: 10497: 10417:Rosmarinic acid 10184:Sulfotep (TEDP) 9854:Ethylsarin (GE) 9734:Cyclosarin (GF) 9704:Chlorfenvinphos 9694:Carbophenothion 9674:Azinphos-methyl 9303: 9293: 9259:Acryloylcholine 9222: 9203: 9195: 9180: 9150: 9145: 9114:Nomuraea rileyi 9052: 9019: 8859:Other chemicals 8854: 8816: 8645: 8416:Chlorfenvinphos 8401:Azinphos-methyl 8377: 8250:Organochlorides 8244: 8181: 8133: 8129:Scheele's Green 8070: 7977: 7968: 7904: 7899: 7898: 7889: 7888: 7884: 7874: 7872: 7860: 7856: 7846: 7844: 7836: 7835: 7831: 7826:(in Malayalam). 7822: 7821: 7817: 7807: 7805: 7796: 7795: 7791: 7781: 7779: 7769: 7765: 7760:(in Malayalam). 7752: 7751: 7747: 7737: 7735: 7727: 7723: 7722: 7718: 7705: 7704: 7700: 7690: 7688: 7677: 7673: 7660: 7659: 7655: 7645: 7643: 7634: 7633: 7629: 7619: 7617: 7612: 7611: 7607: 7597: 7595: 7586: 7585: 7581: 7571: 7569: 7567:hdoa.hawaii.gov 7561: 7560: 7556: 7546: 7544: 7535: 7534: 7530: 7520: 7518: 7509: 7508: 7504: 7494: 7492: 7490:www.cdpr.ca.gov 7484: 7483: 7479: 7469: 7467: 7457: 7453: 7440:cite conference 7437: 7436: 7428: 7424: 7415: 7414: 7410: 7400: 7398: 7385: 7384: 7380: 7370: 7368: 7362: 7358: 7348: 7346: 7337: 7336: 7332: 7322: 7320: 7318:Chicago Tribune 7310: 7306: 7296: 7294: 7286: 7285: 7281: 7271: 7269: 7263: 7259: 7249: 7247: 7243: 7242: 7238: 7228: 7226: 7217: 7216: 7212: 7202: 7200: 7196: 7192: 7191: 7187: 7177: 7175: 7170: 7169: 7165: 7153: 7147: 7140: 7130: 7128: 7127:on 29 July 2014 7119: 7118: 7114: 7104: 7102: 7101:on 29 July 2014 7089: 7088: 7084: 7074: 7072: 7068: 7067: 7063: 7053: 7051: 7045: 7036: 7026: 7024: 7018: 7014: 7004: 7002: 6999: 6993: 6989: 6979: 6977: 6968: 6964: 6963: 6959: 6949: 6947: 6943: 6936: 6932: 6931: 6918: 6908: 6906: 6900: 6896: 6886: 6884: 6879: 6878: 6874: 6864: 6862: 6857: 6856: 6852: 6833: 6832: 6828: 6813: 6809: 6799: 6797: 6779: 6775: 6765: 6763: 6755: 6754: 6750: 6740: 6738: 6729: 6728: 6721: 6668: 6664: 6654: 6652: 6643: 6642: 6635: 6625: 6623: 6622:. 9 August 2018 6614: 6613: 6609: 6600: 6598: 6597:, 29 March 2017 6587: 6586: 6582: 6572: 6570: 6569:. 27 April 2017 6561: 6560: 6556: 6547: 6545: 6538: 6537: 6533: 6524: 6522: 6515: 6514: 6510: 6500: 6498: 6491: 6490: 6483: 6473: 6471: 6468: 6464: 6463: 6459: 6449: 6447: 6435: 6426: 6416: 6414: 6404: 6400: 6390: 6388: 6370: 6366: 6356: 6354: 6344: 6340: 6330: 6328: 6322: 6318: 6308: 6306: 6302: 6292: 6288: 6230: 6226: 6216: 6214: 6205: 6204: 6200: 6190: 6188: 6180: 6179: 6175: 6165: 6163: 6159: 6148: 6142: 6138: 6130: 6126: 6116: 6114: 6106: 6105: 6101: 6091: 6089: 6085: 6074: 6068: 6064: 6013:(15 May 2013). 6007: 6003: 5956: 5949: 5886: 5882: 5827: 5820: 5810: 5808: 5804: 5797: 5791: 5787: 5777: 5775: 5764: 5760: 5750: 5748: 5739: 5738: 5734: 5719: 5694: 5687: 5677: 5675: 5671: 5664: 5656: 5655: 5651: 5641: 5639: 5626: 5625: 5621: 5611: 5609: 5608:. Seattlepi.com 5598: 5594: 5584: 5582: 5578: 5571: 5565: 5561: 5551: 5549: 5545: 5538: 5532: 5528: 5475: 5471: 5463: 5456: 5452: 5451: 5447: 5416:(12): 1175โ€“84. 5402: 5398: 5388: 5386: 5385:on 20 July 2007 5377: 5376: 5372: 5362: 5360: 5350: 5346: 5299: 5295: 5250: 5246: 5192: 5188: 5141: 5137: 5084: 5080: 5027: 5020: 5010: 5008: 5000: 4999: 4995: 4985: 4983: 4980:Regulations.gov 4974:Drew, Danette. 4972: 4961: 4951: 4949: 4938: 4929: 4919: 4917: 4913: 4907: 4900: 4860: 4856: 4803: 4799: 4748: 4741: 4680: 4676: 4623: 4619: 4558: 4554: 4493: 4482: 4435: 4431: 4370: 4366: 4319: 4312: 4273: 4269: 4260: 4256: 4225: 4221: 4176: 4172: 4164: 4157: 4153: 4152: 4148: 4108: 4104: 4048: 4044: 3983: 3976: 3936: 3927: 3884:NeuroToxicology 3880: 3876: 3823:NeuroToxicology 3814: 3810: 3749: 3742: 3689: 3682: 3629: 3625: 3615: 3613: 3609: 3598: 3592: 3588: 3548: 3544: 3534: 3532: 3523: 3522: 3515: 3508: 3486: 3475: 3436: 3427: 3417: 3415: 3406: 3405: 3401: 3391: 3389: 3379: 3375: 3362: 3361: 3357: 3347: 3345: 3332: 3331: 3327: 3317: 3315: 3310: 3309: 3305: 3264:(6): e1000104. 3249: 3245: 3197: 3193: 3166: 3159: 3096: 3092: 3044: 3040: 2985: 2978: 2947:(11): 715โ€“731. 2933: 2926: 2916: 2914: 2907: 2894: 2884: 2882: 2877: 2876: 2872: 2862: 2860: 2849: 2845: 2790: 2786: 2733: 2729: 2698: 2694: 2686: 2679: 2675: 2674: 2670: 2662: 2655: 2651: 2650: 2646: 2636: 2634: 2630: 2623: 2617: 2613: 2603: 2601: 2593: 2587: 2578: 2568: 2566: 2557: 2556: 2552: 2542: 2540: 2529: 2525: 2514: 2510: 2503: 2489: 2485: 2469: 2468: 2461: 2459: 2449: 2445: 2435: 2433: 2424: 2423: 2419: 2409: 2407: 2397: 2390: 2380: 2378: 2368: 2361: 2351: 2349: 2347:Chemistry World 2339: 2332: 2322: 2320: 2310: 2306: 2296: 2294: 2293:on 16 June 2022 2281: 2280: 2276: 2266: 2264: 2263:. 30 March 2016 2255: 2254: 2250: 2235: 2228: 2217: 2213: 2205: 2204: 2200: 2134: 2127: 2117: 2115: 2104: 2103: 2096: 2089: 2075: 2071: 2066: 2062: 2047: 2032: 2025: 2011: 2004: 1994: 1992: 1988: 1981: 1977: 1976: 1972: 1967: 1955: 1943: 1934: 1918: 1910: 1898: 1878: 1866: 1850: 1806: 1782: 1759: 1708: 1668: 1594: 1591: 1520:Clean Water Act 1518:, include: the 1500: 1494: 1479: 1467:bioaccumulation 1455: 1446: 1435: 1429: 1426: 1415: 1402: 1398: 1387: 1381: 1378: 1375: 1366: 1362: 1355: 1331: 1325: 1290: 1285: 1240: 1227:premature labor 1218: 1209:promoter region 1193: 1181:endocannabinoid 1164: 1123: 1118: 1101: 1077: 1055:sex differences 1036:epidemiological 1021: 1016: 1000: 960: 944: 921: 904: 880: 864: 836: 827: 790: 747: 678: 671: 666: 665: 664:  ?) 655: 651: 647: 643: 629: 616: 603: 580: 542: 479: 463: 454: 448: 442: 434: 420: 417: 412: 411: 400: 397: 396: 393: 387: 386: 383: 377: 376: 365: 347: 340: 331: 311: 298: 286: 247: 227: 207: 187: 174: 163: 150: 136: 128: 127: 73: 62: 56: 53: 38: 25: 21: 12: 11: 5: 12073: 12063: 12062: 12057: 12052: 12047: 12042: 12037: 12032: 12015: 12014: 12012: 12011: 12001: 11991: 11981: 11971: 11948: 11945: 11944: 11942: 11941: 11936: 11931: 11926: 11921: 11916: 11914:Food marketing 11911: 11906: 11900: 11898: 11897:Related topics 11894: 11893: 11891: 11890: 11885: 11879: 11874: 11869: 11863: 11857: 11852: 11847: 11840: 11838: 11832: 11831: 11829: 11828: 11823: 11818: 11813: 11808: 11803: 11798: 11793: 11788: 11783: 11778: 11772: 11770: 11756: 11755: 11753: 11752: 11751: 11750: 11745: 11740: 11730: 11725: 11720: 11715: 11710: 11705: 11700: 11695: 11690: 11685: 11680: 11675: 11666: 11661: 11656: 11651: 11646: 11641: 11632: 11623: 11614: 11609: 11604: 11599: 11594: 11589: 11577: 11572: 11567: 11562: 11557: 11552: 11547: 11541: 11539: 11533: 11532: 11530: 11529: 11524: 11519: 11514: 11509: 11504: 11499: 11494: 11489: 11484: 11482:Food additives 11479: 11474: 11469: 11463: 11461: 11455: 11454: 11452: 11451: 11446: 11441: 11436: 11431: 11426: 11421: 11416: 11410: 11408: 11402: 11401: 11399: 11398: 11393: 11388: 11383: 11378: 11373: 11368: 11363: 11358: 11353: 11347: 11345: 11331: 11330: 11328: 11327: 11322: 11317: 11312: 11307: 11306: 11305: 11295: 11289: 11287: 11281: 11280: 11278: 11277: 11272: 11267: 11261: 11259: 11253: 11252: 11250: 11249: 11244: 11239: 11234: 11229: 11223: 11221: 11215: 11214: 11212: 11211: 11204: 11196: 11189: 11184: 11179: 11172: 11167: 11162: 11154: 11146: 11139: 11132: 11125: 11118: 11112: 11110: 11108:Microorganisms 11104: 11103: 11101: 11100: 11095: 11090: 11085: 11080: 11078:Paragonimiasis 11075: 11070: 11065: 11060: 11055: 11050: 11045: 11043:Cyclosporiasis 11040: 11035: 11030: 11024: 11022: 11012: 11011: 11009: 11008: 11007: 11006: 10996: 10995: 10994: 10984: 10979: 10974: 10968: 10966: 10964:Food additives 10960: 10959: 10957: 10956: 10951: 10946: 10941: 10939:Lead poisoning 10936: 10931: 10926: 10921: 10916: 10911: 10905: 10903: 10893: 10892: 10885: 10884: 10877: 10870: 10862: 10853: 10852: 10850: 10849: 10844: 10839: 10834: 10830: 10827: 10826: 10823: 10822: 10820: 10819: 10814: 10799: 10798: 10781: 10779: 10773: 10772: 10770: 10769: 10766:ฮณ-bungarotoxin 10762:ฮฒ-bungarotoxin 10751: 10750: 10716: 10715: 10685: 10683: 10674: 10660: 10659: 10656: 10655: 10653: 10652: 10643: 10641: 10630: 10629: 10627: 10626: 10617: 10616: 10611: 10602: 10600: 10586: 10572: 10571: 10568: 10567: 10565: 10564: 10561: 10556: 10551: 10546: 10541: 10536: 10531: 10526: 10521: 10512: 10510: 10499: 10498: 10496: 10495: 10490: 10485: 10480: 10475: 10465: 10464: 10459: 10454: 10449: 10444: 10439: 10434: 10429: 10424: 10419: 10414: 10409: 10404: 10399: 10394: 10389: 10384: 10379: 10374: 10369: 10364: 10359: 10354: 10349: 10344: 10339: 10334: 10329: 10320: 10319: 10314: 10302: 10280: 10271: 10266: 10261: 10256: 10251: 10246: 10241: 10236: 10231: 10226: 10221: 10216: 10211: 10206: 10201: 10196: 10191: 10186: 10181: 10176: 10171: 10166: 10161: 10156: 10151: 10146: 10141: 10136: 10131: 10126: 10121: 10116: 10111: 10106: 10101: 10096: 10091: 10086: 10081: 10076: 10071: 10066: 10061: 10056: 10051: 10046: 10041: 10036: 10031: 10026: 10024:Novichok agent 10021: 10016: 10011: 10006: 10001: 9996: 9991: 9986: 9981: 9976: 9971: 9966: 9961: 9956: 9951: 9946: 9944:Isofluorophate 9941: 9936: 9931: 9926: 9921: 9916: 9911: 9906: 9901: 9896: 9891: 9886: 9881: 9876: 9871: 9866: 9861: 9856: 9851: 9846: 9841: 9836: 9831: 9826: 9821: 9816: 9811: 9806: 9801: 9796: 9791: 9786: 9781: 9776: 9771: 9766: 9761: 9756: 9751: 9746: 9741: 9736: 9731: 9726: 9721: 9716: 9711: 9706: 9701: 9699:Chlorethoxyfos 9696: 9691: 9686: 9681: 9676: 9671: 9669:Azinphos-ethyl 9666: 9661: 9656: 9646: 9645: 9640: 9635: 9630: 9625: 9620: 9615: 9610: 9605: 9600: 9595: 9590: 9585: 9580: 9575: 9570: 9565: 9560: 9555: 9550: 9545: 9540: 9535: 9530: 9521: 9516: 9511: 9509:Pyridostigmine 9506: 9501: 9496: 9488: 9483: 9478: 9469: 9464: 9459: 9454: 9449: 9444: 9439: 9434: 9429: 9424: 9419: 9414: 9409: 9404: 9399: 9394: 9389: 9384: 9379: 9374: 9369: 9364: 9359: 9354: 9349: 9344: 9339: 9334: 9329: 9324: 9308: 9306: 9295: 9294: 9292: 9291: 9286: 9281: 9276: 9271: 9266: 9261: 9256: 9251: 9246: 9241: 9236: 9227: 9225: 9211: 9197: 9196: 9179: 9178: 9171: 9164: 9156: 9147: 9146: 9144: 9143: 9138: 9131: 9124: 9117: 9110: 9103: 9096: 9089: 9082: 9075: 9070: 9062: 9060: 9054: 9053: 9051: 9050: 9045: 9040: 9035: 9029: 9027: 9021: 9020: 9018: 9017: 9012: 9007: 9002: 8997: 8992: 8987: 8982: 8968: 8963: 8958: 8953: 8943: 8938: 8933: 8931:Hydramethylnon 8928: 8923: 8918: 8913: 8908: 8903: 8898: 8893: 8888: 8883: 8878: 8873: 8868: 8862: 8860: 8856: 8855: 8853: 8852: 8847: 8842: 8837: 8832: 8826: 8824: 8818: 8817: 8815: 8814: 8809: 8804: 8799: 8794: 8789: 8784: 8779: 8761: 8756: 8751: 8746: 8741: 8736: 8731: 8726: 8721: 8716: 8711: 8706: 8701: 8696: 8691: 8686: 8681: 8676: 8671: 8666: 8661: 8655: 8653: 8647: 8646: 8644: 8643: 8638: 8633: 8628: 8623: 8618: 8613: 8608: 8603: 8598: 8593: 8588: 8583: 8578: 8573: 8568: 8563: 8558: 8553: 8548: 8543: 8538: 8533: 8528: 8523: 8518: 8513: 8508: 8503: 8498: 8493: 8488: 8483: 8478: 8473: 8468: 8463: 8458: 8453: 8448: 8443: 8438: 8433: 8428: 8423: 8418: 8413: 8411:Chlorethoxyfos 8408: 8403: 8398: 8393: 8387: 8385: 8379: 8378: 8376: 8375: 8370: 8365: 8360: 8355: 8350: 8345: 8340: 8335: 8330: 8325: 8320: 8315: 8310: 8305: 8300: 8295: 8290: 8285: 8280: 8275: 8270: 8265: 8260: 8254: 8252: 8246: 8245: 8243: 8242: 8237: 8232: 8227: 8222: 8217: 8212: 8207: 8202: 8197: 8191: 8189: 8187:Neonicotinoids 8183: 8182: 8180: 8179: 8174: 8169: 8164: 8159: 8154: 8149: 8143: 8141: 8135: 8134: 8132: 8131: 8126: 8121: 8116: 8111: 8106: 8101: 8096: 8091: 8086: 8080: 8078: 8072: 8071: 8069: 8068: 8063: 8058: 8053: 8048: 8043: 8038: 8033: 8028: 8023: 8018: 8013: 8008: 8003: 7998: 7993: 7987: 7985: 7979: 7978: 7967: 7966: 7959: 7952: 7944: 7938: 7937: 7932: 7927: 7922: 7916: 7910: 7903: 7902:External links 7900: 7897: 7896: 7882: 7854: 7829: 7815: 7789: 7763: 7758:ManoramaOnline 7745: 7716: 7698: 7671: 7668:. 27 May 2014. 7653: 7627: 7614:"Chlorpyrifos" 7605: 7579: 7554: 7543:. 14 June 2018 7528: 7517:. 14 June 2018 7502: 7477: 7451: 7422: 7408: 7378: 7356: 7330: 7304: 7279: 7257: 7236: 7210: 7185: 7163: 7138: 7112: 7082: 7061: 7034: 7012: 6987: 6957: 6946:on 20 May 2008 6916: 6894: 6872: 6850: 6826: 6807: 6773: 6748: 6737:. 27 June 2017 6719: 6682:(1): 347โ€“361. 6662: 6633: 6607: 6580: 6567:Fact Check.Org 6554: 6531: 6508: 6481: 6457: 6424: 6398: 6364: 6338: 6316: 6286: 6244:(4): 756โ€“767. 6224: 6198: 6173: 6136: 6124: 6099: 6062: 6001: 5947: 5880: 5818: 5785: 5758: 5732: 5717: 5685: 5674:on 7 June 2013 5649: 5619: 5592: 5581:on 7 June 2013 5559: 5526: 5495:10.1289/ehp425 5489:(3): 333โ€“341. 5469: 5445: 5396: 5370: 5344: 5293: 5244: 5207:(2): 119โ€“134. 5186: 5135: 5098:(4): 537โ€“542. 5078: 5041:(5): 549โ€“553. 5018: 4993: 4959: 4927: 4898: 4854: 4817:(2): 499โ€“504. 4797: 4762:(3): 449โ€“457. 4739: 4674: 4617: 4552: 4480: 4429: 4364: 4329:(2): 132โ€“151. 4310: 4267: 4254: 4219: 4170: 4146: 4119:(5): 683โ€“689. 4102: 4042: 3997:(3): 297โ€“301. 3974: 3947:(3): 163โ€“176. 3925: 3890:(4): 573โ€“587. 3874: 3808: 3740: 3680: 3623: 3586: 3559:(3): 580โ€“597. 3542: 3513: 3506: 3473: 3425: 3399: 3373: 3355: 3325: 3303: 3243: 3191: 3157: 3090: 3038: 2976: 2924: 2892: 2879:"Chlorpyrifos" 2870: 2859:on 8 July 2004 2843: 2784: 2727: 2692: 2668: 2644: 2611: 2576: 2550: 2539:on 23 May 2014 2523: 2508: 2501: 2483: 2443: 2417: 2388: 2359: 2330: 2304: 2274: 2248: 2226: 2211: 2198: 2125: 2094: 2087: 2069: 2060: 2030: 2023: 2002: 1969: 1968: 1966: 1963: 1962: 1961: 1954: 1951: 1942: 1939: 1933: 1930: 1917: 1914: 1909: 1906: 1897: 1894: 1877: 1876:European Union 1874: 1865: 1862: 1849: 1846: 1805: 1802: 1781: 1778: 1758: 1755: 1707: 1704: 1667: 1664: 1623:Andrew Liveris 1589: 1493: 1490: 1478: 1475: 1454: 1451: 1448: 1447: 1412:of the subject 1410:worldwide view 1405: 1403: 1396: 1389: 1388: 1369: 1367: 1360: 1354: 1351: 1327:Main article: 1324: 1321: 1289: 1286: 1284: 1281: 1239: 1238:Human exposure 1236: 1217: 1214: 1192: 1189: 1163: 1160: 1122: 1119: 1117: 1114: 1110:vector control 1100: 1097: 1076: 1073: 1034:: In multiple 1020: 1017: 1015: 1012: 999: 998:Tourist deaths 996: 959: 956: 943: 940: 920: 917: 903: 900: 884:acute toxicity 879: 878:Human toxicity 876: 863: 860: 840:enters insects 835: 832: 826: 823: 796:Use in the USA 789: 786: 746: 743: 727:European Union 723:United Kingdom 676: 673: 672: 667: 645: 644: 640:standard state 637: 634: 633: 630: 624: 621: 620: 617: 611: 608: 607: 604: 598: 595: 594: 585: 584: 581: 578: 575: 574: 565: 564: 560: 559: 556: 547: 546: 543: 538: 535: 534: 531: 525: 524: 521: 515: 514: 511: 505: 504: 498: 492: 491: 488: 484: 483: 477: 471: 470: 461: 452: 446: 440: 435: 430: 427: 426: 422: 421: 419: 418: 415: 407: 406: 405: 402: 401: 399: 398: 394: 391: 390: 388: 384: 381: 380: 372: 371: 370: 367: 366: 364: 363: 350: 348: 336: 333: 332: 330: 329: 321: 319: 313: 312: 310: 309: 301: 299: 291: 288: 287: 285: 284: 276: 274: 268: 267: 257: 249: 248: 246: 245: 237: 235: 229: 228: 226: 225: 217: 215: 209: 208: 206: 205: 197: 195: 189: 188: 186: 185: 177: 175: 168: 165: 164: 162: 161: 153: 151: 146: 143: 142: 138: 137: 134: 130: 129: 114: 113: 107: 106: 102: 101: 93: 92: 75: 74: 35:of the subject 33:worldwide view 28: 26: 19: 9: 6: 4: 3: 2: 12072: 12061: 12058: 12056: 12053: 12051: 12048: 12046: 12043: 12041: 12038: 12036: 12033: 12031: 12028: 12027: 12025: 12010: 12002: 12000: 11996: 11992: 11990: 11982: 11980: 11972: 11970: 11960: 11955: 11950: 11949: 11946: 11940: 11937: 11935: 11932: 11930: 11927: 11925: 11922: 11920: 11919:Food politics 11917: 11915: 11912: 11910: 11907: 11905: 11902: 11901: 11899: 11895: 11889: 11886: 11884:(South Korea) 11883: 11880: 11878: 11875: 11873: 11870: 11867: 11864: 11861: 11858: 11856: 11853: 11851: 11848: 11845: 11842: 11841: 11839: 11837: 11833: 11827: 11824: 11822: 11819: 11817: 11814: 11812: 11809: 11807: 11804: 11802: 11799: 11797: 11794: 11792: 11789: 11787: 11784: 11782: 11779: 11777: 11774: 11773: 11771: 11769: 11765: 11761: 11757: 11749: 11748:United States 11746: 11744: 11741: 11739: 11736: 11735: 11734: 11731: 11729: 11726: 11724: 11721: 11719: 11716: 11714: 11711: 11709: 11706: 11704: 11701: 11699: 11696: 11694: 11691: 11689: 11686: 11684: 11681: 11679: 11676: 11674: 11672: 11669:2011 Germany 11667: 11665: 11662: 11660: 11657: 11655: 11652: 11650: 11647: 11645: 11642: 11640: 11638: 11633: 11631: 11629: 11626:1996 Odwalla 11624: 11622: 11620: 11615: 11613: 11610: 11608: 11605: 11603: 11600: 11598: 11595: 11593: 11590: 11586: 11581: 11578: 11576: 11573: 11571: 11568: 11566: 11563: 11561: 11558: 11556: 11553: 11551: 11548: 11546: 11543: 11542: 11540: 11538: 11534: 11528: 11525: 11523: 11520: 11518: 11515: 11513: 11510: 11508: 11505: 11503: 11500: 11498: 11495: 11493: 11490: 11488: 11485: 11483: 11480: 11478: 11475: 11473: 11470: 11468: 11465: 11464: 11462: 11460: 11456: 11450: 11447: 11445: 11442: 11440: 11437: 11435: 11432: 11430: 11427: 11425: 11422: 11420: 11417: 11415: 11412: 11411: 11409: 11407: 11403: 11397: 11394: 11392: 11389: 11387: 11384: 11382: 11379: 11377: 11374: 11372: 11369: 11367: 11364: 11362: 11359: 11357: 11354: 11352: 11349: 11348: 11346: 11344: 11340: 11336: 11332: 11326: 11323: 11321: 11318: 11316: 11313: 11311: 11308: 11304: 11301: 11300: 11299: 11296: 11294: 11291: 11290: 11288: 11286: 11282: 11276: 11273: 11271: 11268: 11266: 11263: 11262: 11260: 11258: 11257:Preservatives 11254: 11248: 11247:Methamidophos 11245: 11243: 11240: 11238: 11235: 11233: 11230: 11228: 11225: 11224: 11222: 11220: 11216: 11210: 11209: 11205: 11203: 11202: 11197: 11195: 11194: 11190: 11188: 11185: 11183: 11180: 11178: 11177: 11173: 11171: 11168: 11166: 11163: 11161: 11159: 11155: 11153: 11151: 11147: 11145: 11144: 11140: 11138: 11137: 11133: 11131: 11130: 11126: 11124: 11123: 11119: 11117: 11114: 11113: 11111: 11109: 11105: 11099: 11096: 11094: 11091: 11089: 11088:Toxoplasmosis 11086: 11084: 11081: 11079: 11076: 11074: 11071: 11069: 11066: 11064: 11061: 11059: 11056: 11054: 11051: 11049: 11046: 11044: 11041: 11039: 11036: 11034: 11031: 11029: 11026: 11025: 11023: 11021: 11017: 11013: 11005: 11002: 11001: 11000: 10999:Vegetable oil 10997: 10993: 10990: 10989: 10988: 10985: 10983: 10980: 10978: 10975: 10973: 10970: 10969: 10967: 10965: 10961: 10955: 10952: 10950: 10947: 10945: 10942: 10940: 10937: 10935: 10932: 10930: 10927: 10925: 10922: 10920: 10917: 10915: 10912: 10910: 10907: 10906: 10904: 10902: 10898: 10894: 10890: 10883: 10878: 10876: 10871: 10869: 10864: 10863: 10860: 10848: 10845: 10843: 10840: 10838: 10835: 10832: 10831: 10828: 10818: 10815: 10812: 10808: 10804: 10801: 10800: 10797: 10794: 10789: 10783: 10782: 10780: 10778: 10774: 10767: 10763: 10759: 10758:Bungarotoxins 10756: 10753: 10752: 10748: 10744: 10740: 10736: 10732: 10729: 10728:inactivators: 10724: 10718: 10717: 10713: 10709: 10705: 10701: 10698: 10697:inactivators: 10693: 10687: 10686: 10684: 10682: 10678: 10675: 10671: 10665: 10661: 10651: 10648: 10645: 10644: 10642: 10637: 10631: 10625: 10622: 10619: 10618: 10615: 10612: 10610: 10607: 10604: 10603: 10601: 10596: 10590: 10587: 10583: 10577: 10573: 10562: 10560: 10559:ZINC-12613047 10557: 10555: 10552: 10550: 10547: 10545: 10542: 10540: 10537: 10535: 10532: 10530: 10527: 10525: 10522: 10520: 10517: 10514: 10513: 10511: 10506: 10500: 10494: 10491: 10489: 10486: 10484: 10481: 10479: 10476: 10474: 10470: 10467: 10466: 10463: 10460: 10458: 10455: 10453: 10450: 10448: 10445: 10443: 10440: 10438: 10435: 10433: 10430: 10428: 10425: 10423: 10420: 10418: 10415: 10413: 10410: 10408: 10405: 10403: 10402:Lactucopicrin 10400: 10398: 10395: 10393: 10390: 10388: 10385: 10383: 10380: 10378: 10375: 10373: 10370: 10368: 10365: 10363: 10360: 10358: 10355: 10353: 10350: 10348: 10345: 10343: 10340: 10338: 10335: 10333: 10330: 10328: 10325: 10322: 10321: 10318: 10315: 10312: 10311: 10306: 10303: 10300: 10296: 10292: 10288: 10284: 10281: 10279: 10275: 10272: 10270: 10267: 10265: 10262: 10260: 10257: 10255: 10252: 10250: 10247: 10245: 10242: 10240: 10237: 10235: 10234:Trichloronate 10232: 10230: 10227: 10225: 10222: 10220: 10217: 10215: 10212: 10210: 10207: 10205: 10202: 10200: 10197: 10195: 10192: 10190: 10187: 10185: 10182: 10180: 10177: 10175: 10172: 10170: 10167: 10165: 10162: 10160: 10157: 10155: 10152: 10150: 10147: 10145: 10142: 10140: 10137: 10135: 10132: 10130: 10127: 10125: 10122: 10120: 10117: 10115: 10112: 10110: 10107: 10105: 10102: 10100: 10097: 10095: 10092: 10090: 10087: 10085: 10082: 10080: 10077: 10075: 10072: 10070: 10067: 10065: 10062: 10060: 10057: 10055: 10052: 10050: 10047: 10045: 10042: 10040: 10037: 10035: 10032: 10030: 10027: 10025: 10022: 10020: 10017: 10015: 10012: 10010: 10009:Monocrotophos 10007: 10005: 10002: 10000: 9997: 9995: 9992: 9990: 9987: 9985: 9982: 9980: 9977: 9975: 9974:Methamidophos 9972: 9970: 9967: 9965: 9962: 9960: 9957: 9955: 9952: 9950: 9947: 9945: 9942: 9940: 9937: 9935: 9932: 9930: 9927: 9925: 9922: 9920: 9917: 9915: 9912: 9910: 9907: 9905: 9902: 9900: 9897: 9895: 9892: 9890: 9887: 9885: 9882: 9880: 9877: 9875: 9872: 9870: 9867: 9865: 9862: 9860: 9857: 9855: 9852: 9850: 9849:Echothiophate 9847: 9845: 9842: 9840: 9837: 9835: 9832: 9830: 9827: 9825: 9822: 9820: 9817: 9815: 9812: 9810: 9807: 9805: 9802: 9800: 9797: 9795: 9792: 9790: 9787: 9785: 9782: 9780: 9777: 9775: 9772: 9770: 9767: 9765: 9762: 9760: 9757: 9755: 9752: 9750: 9747: 9745: 9742: 9740: 9737: 9735: 9732: 9730: 9727: 9725: 9722: 9720: 9717: 9715: 9712: 9710: 9707: 9705: 9702: 9700: 9697: 9695: 9692: 9690: 9687: 9685: 9682: 9680: 9677: 9675: 9672: 9670: 9667: 9665: 9662: 9660: 9657: 9655: 9651: 9650:Irreversible: 9648: 9647: 9644: 9641: 9639: 9636: 9634: 9631: 9629: 9626: 9624: 9621: 9619: 9616: 9614: 9611: 9609: 9606: 9604: 9601: 9599: 9596: 9594: 9591: 9589: 9586: 9584: 9581: 9579: 9576: 9574: 9571: 9569: 9566: 9564: 9561: 9559: 9556: 9554: 9551: 9549: 9546: 9544: 9541: 9539: 9536: 9534: 9531: 9529: 9525: 9522: 9520: 9517: 9515: 9514:Quilostigmine 9512: 9510: 9507: 9505: 9504:Physostigmine 9502: 9500: 9497: 9495: 9492: 9489: 9487: 9484: 9482: 9479: 9477: 9474:; Stigmines: 9473: 9470: 9468: 9465: 9463: 9460: 9458: 9455: 9453: 9450: 9448: 9445: 9443: 9440: 9438: 9435: 9433: 9430: 9428: 9425: 9423: 9420: 9418: 9415: 9413: 9410: 9408: 9405: 9403: 9400: 9398: 9395: 9393: 9390: 9388: 9385: 9383: 9380: 9378: 9375: 9373: 9372:Chloropropham 9370: 9368: 9365: 9363: 9360: 9358: 9355: 9353: 9350: 9348: 9345: 9343: 9340: 9338: 9335: 9333: 9330: 9328: 9325: 9323: 9319: 9316: 9314: 9310: 9309: 9307: 9302: 9296: 9290: 9287: 9285: 9282: 9280: 9277: 9275: 9272: 9270: 9267: 9265: 9262: 9260: 9257: 9255: 9252: 9250: 9247: 9245: 9242: 9240: 9237: 9235: 9232: 9229: 9228: 9226: 9221: 9215: 9212: 9208: 9202: 9198: 9194: 9191: 9187: 9184: 9183:Acetylcholine 9177: 9172: 9170: 9165: 9163: 9158: 9157: 9154: 9142: 9139: 9137: 9136: 9132: 9130: 9129: 9125: 9123: 9122: 9118: 9116: 9115: 9111: 9109: 9108: 9104: 9102: 9101: 9097: 9095: 9094: 9090: 9088: 9087: 9083: 9081: 9080: 9076: 9074: 9071: 9069: 9068: 9064: 9063: 9061: 9059: 9058:Biopesticides 9055: 9049: 9046: 9044: 9041: 9039: 9036: 9034: 9031: 9030: 9028: 9026: 9022: 9016: 9015:Metaflumizone 9013: 9011: 9008: 9006: 9003: 9001: 8998: 8996: 8993: 8991: 8988: 8986: 8983: 8980: 8976: 8972: 8969: 8967: 8964: 8962: 8959: 8957: 8954: 8951: 8947: 8944: 8942: 8939: 8937: 8934: 8932: 8929: 8927: 8924: 8922: 8919: 8917: 8914: 8912: 8909: 8907: 8904: 8902: 8899: 8897: 8896:Chlordimeform 8894: 8892: 8889: 8887: 8884: 8882: 8879: 8877: 8874: 8872: 8869: 8867: 8864: 8863: 8861: 8857: 8851: 8848: 8846: 8843: 8841: 8840:Flubendiamide 8838: 8836: 8833: 8831: 8828: 8827: 8825: 8823: 8819: 8813: 8812:Transfluthrin 8810: 8808: 8805: 8803: 8800: 8798: 8795: 8793: 8790: 8788: 8785: 8783: 8780: 8777: 8773: 8769: 8765: 8762: 8760: 8757: 8755: 8752: 8750: 8747: 8745: 8742: 8740: 8737: 8735: 8732: 8730: 8727: 8725: 8722: 8720: 8719:Fenpropathrin 8717: 8715: 8712: 8710: 8709:Esfenvalerate 8707: 8705: 8702: 8700: 8697: 8695: 8692: 8690: 8687: 8685: 8682: 8680: 8677: 8675: 8672: 8670: 8667: 8665: 8662: 8660: 8657: 8656: 8654: 8652: 8648: 8642: 8639: 8637: 8634: 8632: 8629: 8627: 8624: 8622: 8619: 8617: 8614: 8612: 8609: 8607: 8604: 8602: 8599: 8597: 8594: 8592: 8589: 8587: 8584: 8582: 8579: 8577: 8574: 8572: 8569: 8567: 8564: 8562: 8559: 8557: 8554: 8552: 8549: 8547: 8544: 8542: 8541:Monocrotophos 8539: 8537: 8534: 8532: 8529: 8527: 8524: 8522: 8521:Methamidophos 8519: 8517: 8514: 8512: 8509: 8507: 8504: 8502: 8499: 8497: 8494: 8492: 8489: 8487: 8484: 8482: 8479: 8477: 8474: 8472: 8469: 8467: 8464: 8462: 8459: 8457: 8454: 8452: 8449: 8447: 8444: 8442: 8439: 8437: 8434: 8432: 8429: 8427: 8424: 8422: 8419: 8417: 8414: 8412: 8409: 8407: 8404: 8402: 8399: 8397: 8394: 8392: 8389: 8388: 8386: 8384: 8380: 8374: 8371: 8369: 8366: 8364: 8361: 8359: 8356: 8354: 8351: 8349: 8346: 8344: 8341: 8339: 8336: 8334: 8331: 8329: 8326: 8324: 8321: 8319: 8316: 8314: 8311: 8309: 8306: 8304: 8301: 8299: 8296: 8294: 8291: 8289: 8286: 8284: 8281: 8279: 8276: 8274: 8271: 8269: 8266: 8264: 8261: 8259: 8256: 8255: 8253: 8251: 8247: 8241: 8238: 8236: 8233: 8231: 8228: 8226: 8223: 8221: 8218: 8216: 8213: 8211: 8208: 8206: 8203: 8201: 8198: 8196: 8193: 8192: 8190: 8188: 8184: 8178: 8175: 8173: 8170: 8168: 8165: 8163: 8160: 8158: 8155: 8153: 8152:Diflubenzuron 8150: 8148: 8145: 8144: 8142: 8140: 8136: 8130: 8127: 8125: 8122: 8120: 8117: 8115: 8112: 8110: 8107: 8105: 8102: 8100: 8097: 8095: 8092: 8090: 8087: 8085: 8082: 8081: 8079: 8077: 8073: 8067: 8064: 8062: 8059: 8057: 8054: 8052: 8049: 8047: 8044: 8042: 8039: 8037: 8034: 8032: 8029: 8027: 8024: 8022: 8019: 8017: 8014: 8012: 8009: 8007: 8004: 8002: 7999: 7997: 7994: 7992: 7989: 7988: 7986: 7984: 7980: 7976: 7972: 7965: 7960: 7958: 7953: 7951: 7946: 7945: 7942: 7936: 7933: 7931: 7928: 7926: 7923: 7920: 7917: 7914: 7911: 7909: 7906: 7905: 7892: 7886: 7871: 7870: 7865: 7858: 7843: 7839: 7833: 7825: 7819: 7803: 7799: 7793: 7778: 7774: 7767: 7759: 7755: 7749: 7733: 7726: 7720: 7712: 7708: 7702: 7686: 7682: 7675: 7667: 7663: 7657: 7641: 7637: 7631: 7615: 7609: 7593: 7589: 7583: 7568: 7564: 7558: 7542: 7538: 7532: 7516: 7512: 7506: 7491: 7487: 7481: 7466: 7462: 7455: 7447: 7441: 7433: 7426: 7418: 7412: 7396: 7392: 7388: 7382: 7367: 7360: 7344: 7340: 7334: 7319: 7315: 7308: 7293: 7289: 7283: 7268: 7261: 7246: 7240: 7224: 7220: 7214: 7195: 7189: 7173: 7167: 7159: 7152: 7145: 7143: 7126: 7122: 7116: 7100: 7096: 7092: 7086: 7071: 7065: 7050: 7043: 7041: 7039: 7023: 7016: 6998: 6991: 6976: 6975: 6967: 6961: 6942: 6935: 6929: 6927: 6925: 6923: 6921: 6905: 6898: 6882: 6876: 6860: 6854: 6846: 6842: 6841: 6836: 6830: 6822: 6818: 6811: 6796: 6792: 6788: 6784: 6777: 6762: 6758: 6752: 6736: 6732: 6726: 6724: 6715: 6711: 6707: 6703: 6699: 6695: 6690: 6685: 6681: 6677: 6673: 6666: 6650: 6646: 6640: 6638: 6621: 6617: 6611: 6596: 6595: 6590: 6584: 6568: 6564: 6558: 6543: 6542: 6535: 6520: 6519: 6512: 6496: 6495: 6488: 6486: 6467: 6461: 6446: 6445: 6440: 6433: 6431: 6429: 6413: 6409: 6402: 6387: 6383: 6379: 6375: 6368: 6353: 6349: 6342: 6327: 6320: 6301: 6297: 6290: 6283: 6279: 6275: 6270: 6265: 6261: 6257: 6252: 6247: 6243: 6239: 6235: 6228: 6212: 6208: 6202: 6187: 6183: 6177: 6158: 6154: 6147: 6140: 6133: 6128: 6113: 6109: 6103: 6084: 6080: 6073: 6066: 6058: 6054: 6049: 6044: 6040: 6036: 6032: 6028: 6024: 6020: 6016: 6012: 6005: 5997: 5993: 5988: 5983: 5978: 5973: 5969: 5965: 5961: 5954: 5952: 5943: 5939: 5934: 5929: 5925: 5921: 5916: 5911: 5907: 5903: 5900:(1): โ€“77547. 5899: 5895: 5891: 5884: 5876: 5872: 5867: 5862: 5857: 5852: 5848: 5844: 5841:(4): โ€“94482. 5840: 5836: 5832: 5825: 5823: 5803: 5796: 5789: 5773: 5769: 5762: 5746: 5742: 5736: 5728: 5724: 5720: 5714: 5710: 5706: 5702: 5701: 5692: 5690: 5670: 5663: 5661: 5653: 5637: 5633: 5631: 5623: 5607: 5603: 5596: 5577: 5570: 5563: 5544: 5537: 5530: 5522: 5518: 5513: 5508: 5504: 5500: 5496: 5492: 5488: 5484: 5480: 5473: 5462: 5455: 5449: 5441: 5437: 5432: 5427: 5423: 5419: 5415: 5411: 5407: 5400: 5384: 5380: 5374: 5359: 5355: 5348: 5340: 5336: 5331: 5326: 5321: 5316: 5312: 5308: 5304: 5297: 5289: 5285: 5281: 5277: 5272: 5267: 5263: 5259: 5255: 5248: 5240: 5236: 5231: 5226: 5222: 5218: 5214: 5210: 5206: 5202: 5198: 5190: 5182: 5178: 5173: 5168: 5163: 5158: 5154: 5150: 5146: 5139: 5131: 5127: 5122: 5117: 5113: 5109: 5105: 5101: 5097: 5093: 5089: 5082: 5074: 5070: 5065: 5060: 5056: 5052: 5048: 5044: 5040: 5036: 5032: 5025: 5023: 5007: 5003: 4997: 4981: 4977: 4970: 4968: 4966: 4964: 4947: 4943: 4936: 4934: 4932: 4912: 4905: 4903: 4894: 4890: 4886: 4882: 4878: 4874: 4870: 4866: 4858: 4850: 4846: 4841: 4836: 4832: 4828: 4824: 4820: 4816: 4812: 4808: 4801: 4793: 4789: 4785: 4781: 4777: 4773: 4769: 4765: 4761: 4757: 4753: 4746: 4744: 4735: 4731: 4726: 4721: 4717: 4713: 4709: 4705: 4701: 4697: 4693: 4689: 4685: 4678: 4670: 4666: 4661: 4656: 4652: 4648: 4644: 4640: 4636: 4632: 4628: 4621: 4613: 4609: 4604: 4599: 4595: 4591: 4587: 4583: 4579: 4575: 4571: 4567: 4563: 4556: 4548: 4544: 4539: 4534: 4530: 4526: 4522: 4518: 4514: 4510: 4506: 4502: 4498: 4491: 4489: 4487: 4485: 4476: 4472: 4468: 4464: 4460: 4456: 4452: 4448: 4444: 4440: 4433: 4425: 4421: 4416: 4411: 4407: 4403: 4399: 4395: 4391: 4387: 4383: 4379: 4375: 4368: 4360: 4356: 4352: 4348: 4344: 4340: 4336: 4332: 4328: 4324: 4317: 4315: 4306: 4302: 4298: 4294: 4290: 4286: 4283:(1โ€“2): 1โ€“13. 4282: 4278: 4271: 4264: 4258: 4250: 4246: 4242: 4238: 4234: 4230: 4223: 4215: 4211: 4207: 4203: 4198: 4193: 4189: 4185: 4181: 4174: 4163: 4156: 4150: 4142: 4138: 4134: 4130: 4126: 4122: 4118: 4114: 4106: 4098: 4094: 4090: 4086: 4082: 4078: 4074: 4070: 4066: 4062: 4058: 4054: 4046: 4038: 4034: 4029: 4024: 4020: 4016: 4012: 4008: 4004: 4000: 3996: 3992: 3988: 3981: 3979: 3970: 3966: 3962: 3958: 3954: 3950: 3946: 3942: 3934: 3932: 3930: 3921: 3917: 3913: 3909: 3905: 3901: 3897: 3893: 3889: 3885: 3878: 3870: 3866: 3861: 3856: 3852: 3848: 3844: 3840: 3836: 3832: 3828: 3824: 3820: 3812: 3804: 3800: 3795: 3790: 3786: 3782: 3778: 3774: 3770: 3766: 3762: 3758: 3754: 3747: 3745: 3736: 3732: 3727: 3722: 3718: 3714: 3710: 3706: 3702: 3698: 3694: 3687: 3685: 3676: 3672: 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1197:paraoxonase 1 1188: 1186: 1182: 1178: 1174: 1170: 1159: 1156: 1152: 1148: 1144: 1140: 1136: 1127: 1113: 1111: 1106: 1096: 1094: 1088: 1084: 1082: 1072: 1070: 1066: 1061: 1056: 1052: 1048: 1044: 1041: 1037: 1033: 1032:Human studies 1029: 1027: 1011: 1009: 1005: 995: 993: 989: 985: 981: 977: 976:acetylcholine 973: 969: 965: 955: 953: 948: 939: 936: 933: 932:neuromuscular 929: 926: 925:acetylcholine 916: 913: 909: 899: 897: 893: 892:developmental 889: 885: 875: 873: 869: 859: 857: 853: 849: 845: 841: 838:Chlorpyrifos 831: 822: 818: 815: 810: 808: 804: 794: 781: 777: 775: 771: 769: 765: 760: 756: 752: 742: 740: 736: 732: 728: 724: 719: 717: 713: 708: 706: 702: 698: 694: 690: 686: 682: 670: 663: 658: 641: 635: 631: 627: 623: 622: 618: 615:(Recommended) 614: 610: 609: 605: 602:(Permissible) 601: 597: 596: 592: 591: 586: 582: 577: 576: 572: 571: 566: 561: 557: 555: 554: 549: 548: 544: 541: 537: 536: 532: 530: 529:Boiling point 527: 526: 522: 520: 519:Melting point 517: 516: 512: 510: 507: 506: 502: 499: 497: 494: 493: 489: 486: 485: 478: 476: 473: 472: 436: 433: 429: 428: 423: 414: 413: 410: 403: 389: 379: 378: 375: 368: 360: 356: 355:DTXSID4020458 352: 351: 349: 339: 335: 334: 327: 323: 322: 320: 318: 315: 314: 307: 303: 302: 300: 294: 290: 289: 282: 278: 277: 275: 273: 270: 269: 265: 261: 258: 256: 254:ECHA InfoCard 251: 250: 243: 239: 238: 236: 234: 231: 230: 223: 219: 218: 216: 214: 211: 210: 203: 199: 198: 196: 194: 191: 190: 183: 179: 178: 176: 172: 167: 166: 159: 155: 154: 152: 149: 145: 144: 139: 131: 125: 121: 117: 112: 108: 103: 99: 94: 90: 85: 82:Chlorpyrifos 79: 71: 68: 60: 50: 46: 42: 36: 34: 27: 18: 17: 12060:Ethyl esters 11929:Food quality 11836:Institutions 11670: 11636: 11627: 11618: 11502:Nitrosamines 11265:Benzoic acid 11227:Chlorpyrifos 11226: 11206: 11200: 11191: 11174: 11157: 11149: 11141: 11134: 11127: 11120: 11098:Trichuriasis 11083:Toxocariasis 11053:Enterobiasis 10929:Formaldehyde 10802: 10796:ฮฑ-Latrotoxin 10784: 10754: 10719: 10688: 10646: 10620: 10605: 10549:Rivastigmine 10515: 10469:Reactivators 10442:Ungiminorine 10397:Kobophenol A 10362:Coronaridine 10352:Bulbocapnine 10347:Arisugacin A 10323: 10308: 10194:Tebupirimfos 10074:Phosphamidon 9979:Methidathion 9884:Fenitrothion 9709:Chlorpyrifos 9708: 9649: 9524:Terestigmine 9519:Rivastigmine 9481:Eptastigmine 9432:Phenmedipham 9402:Formparanate 9387:Ethiofencarb 9320:Carbamates: 9317: 9311: 9230: 9133: 9126: 9119: 9112: 9105: 9098: 9091: 9084: 9077: 9065: 9000:Tebufenpyrad 8995:Tebufenozide 8901:Chlorfenapyr 8876:Azadirachtin 8807:Tralomethrin 8802:Tetramethrin 8744:Metofluthrin 8699:Deltamethrin 8694:Cyphenothrin 8689:Cypermethrin 8674:Bioallethrin 8621:Tebupirimfos 8526:Methidathion 8496:Fenitrothion 8421:Chlorpyrifos 8420: 8396:Azamethiphos 8358:Methoxychlor 8240:Thiamethoxam 8230:Paichongding 8215:Imidaclothiz 8210:Imidacloprid 8200:Clothianidin 8177:Pyriproxyfen 8157:Flufenoxuron 8147:Benzoylureas 8006:Butocarboxim 7975:Insecticides 7971:Pest control 7885: 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Retrieved 1986:the original 1973: 1944: 1935: 1919: 1911: 1899: 1882: 1879: 1867: 1859: 1851: 1843: 1840: 1836: 1828: 1821: 1811: 1807: 1794: 1783: 1775: 1760: 1743:buffer zones 1728: 1709: 1700: 1696: 1693: 1689: 1685: 1681: 1669: 1661: 1649: 1646: 1642: 1639: 1635:Earthjustice 1631: 1627: 1615: 1607: 1603:Scott Pruitt 1600: 1596: 1585: 1579: 1576: 1560: 1548: 1501: 1487: 1480: 1456: 1436: 1427: 1407: 1379: 1371: 1347: 1339: 1332: 1306: 1291: 1288:Aquatic life 1262: 1258: 1254: 1250: 1241: 1219: 1194: 1179:and several 1165: 1132: 1104: 1102: 1093:brush border 1089: 1085: 1078: 1046: 1045: 1040:birth weight 1031: 1030: 1022: 1001: 961: 949: 945: 937: 922: 905: 881: 865: 837: 828: 819: 811: 799: 773: 767: 763: 758: 750: 748: 720: 709: 688: 684: 681:Chlorpyrifos 680: 679: 589: 579:Main hazards 568: 552: 222:ChEMBL463210 141:Identifiers 133:Other names 123: 119: 115: 78: 63: 54: 30: 12009:WikiProject 11846:(Hong Kong) 11583: [ 11545:Devon colic 11419:Breast milk 11391:Nonylphenol 11366:Bisphenol A 11303:controversy 11170:Hepatitis E 11165:Hepatitis A 11143:Enterovirus 11136:Cronobacter 11093:Trichinosis 11063:Fasciolosis 11033:Anisakiasis 11004:controversy 10897:Adulterants 10647:Inhibitors: 10624:Coluracetam 10606:Inhibitors: 10576:Transporter 10516:Inhibitors: 10488:Pralidoxime 10382:Cyclanoline 10332:ฮฑ-Viniferin 10229:Trichlorfon 9994:Metrifonate 9909:Fosthiazate 9894:Fluorotabun 9769:Dicrotophos 9724:Crotylsarin 9568:Huperzine A 9563:Galantamine 9558:Edrophonium 9491:Neostigmine 9486:Ganstigmine 9452:Propamocarb 9397:Formetanate 9382:Ethienocarb 9362:Carbosulfan 9352:Carbetamide 9347:Carbendazim 9318:Reversible: 9231:Inhibitors: 9073:Baculovirus 9025:Metabolites 8990:Sulfluramid 8792:Silafluofen 8759:Prallethrin 8739:Imiprothrin 8734:Fluvalinate 8724:Fenvalerate 8684:Cyhalothrin 8659:Acrinathrin 8651:Pyrethroids 8641:Trichlorfon 8506:Fosthiazate 8451:Dicrotophos 8235:Thiacloprid 8205:Dinotefuran 8195:Acetamiprid 8124:Paris Green 8031:Ethienocarb 8021:Carbosulfan 7515:Hawaii 24/7 5678:20 November 5642:20 November 5612:20 November 5389:20 November 4507:: 115โ€“122. 3829:: 158โ€“168. 3763:: 248โ€“256. 2885:20 November 2749:: 372โ€“380. 2604:28 February 2569:20 November 1941:Manufacture 1908:New Zealand 1900:The FSSAI ( 1522:(CWA); the 1300:or through 1294:crustaceans 1195:The enzyme 1026:metabolites 1019:Development 1008:myocarditis 972:pralidoxime 866:Like other 844:food plants 825:Application 573:(OHS/OSH): 487:Appearance 425:Properties 260:100.018.969 202:CHEBI:34631 57:August 2021 12024:Categories 11760:Regulation 11743:death toll 11512:Shortening 11477:Acrylamide 11406:Food fraud 11386:Mycotoxins 11219:Pesticides 11193:Salmonella 11068:Giardiasis 11028:Amoebiasis 10972:Flavorings 10811:versutoxin 10807:robustoxin 10681:Inhibitors 10670:modulators 10621:Enhancers: 10582:modulators 10539:Ladostigil 10529:Conodurine 10524:Affinisine 10437:Ungeremine 10412:Phosacetim 10372:Corynoline 10367:Corydaline 10357:Conodurine 10342:Affinisine 10278:Demecarium 10276:; Others: 10189:Tabun (GA) 10179:Soman (GD) 10169:Sarin (GB) 10089:Profenofos 9949:Isoxathion 9934:Guanitoxin 9904:Formothion 9879:Fenamiphos 9809:Disulfoton 9804:Dioxathion 9794:Dimethoate 9764:Dichlorvos 9598:Ladostigil 9588:Ipidacrine 9533:Ambenonium 9528:Acotiamide 9526:; Others: 9499:Phenserine 9476:Distigmine 9467:Thiodicarb 9442:Pirimicarb 9407:Methiocarb 9392:Fenobucarb 9367:Chlorbufam 9357:Carbofuran 9332:Bendiocarb 9313:Inhibitors 9207:modulators 9193:modulators 9186:metabolism 9005:Veracevine 8936:Indoxacarb 8926:Fluralaner 8916:Fenoxycarb 8911:Fenazaquin 8906:Cyromazine 8886:Buprofezin 8866:Afoxolaner 8797:Tefluthrin 8787:Resmethrin 8754:Phenothrin 8749:Permethrin 8729:Flumethrin 8714:Etofenprox 8704:Empenthrin 8679:Cyfluthrin 8669:Bifenthrin 8664:Allethrins 8601:Quinalphos 8571:Phenthoate 8511:Isoxathion 8491:Fenamiphos 8476:Disulfoton 8471:Dioxathion 8466:Dimethoate 8446:Dichlorvos 8368:Tetradifon 8343:Heptachlor 8333:Endosulfan 8278:Cyclodiene 8225:Nithiazine 8220:Nitenpyram 8172:Methoprene 8162:Hydroprene 8089:Boric acid 8041:Isoprocarb 8036:Fenobucarb 8016:Carbofuran 8001:Bendiocarb 7983:Carbamates 7343:CDC- NIOSH 7027:4 February 7005:4 February 6655:24 January 6450:8 November 6417:31 October 6217:7 November 6117:2 November 5363:15 October 5011:15 October 4501:Toxicology 3535:15 October 3202:The Lancet 3049:The Lancet 2999:(1): 357. 2153:: 104587. 1965:References 1804:State laws 1496:See also: 1382:March 2022 1353:Regulation 1304:exposure. 1269:Washington 1201:hydrolysis 1185:cyclic AMP 1139:metabolite 1060:cyclic AMP 1004:Chiang Mai 475:Molar mass 326:JCS58I644W 233:ChemSpider 169:3D model ( 148:CAS Number 11806:ISO 22000 11768:watchdogs 11764:standards 11738:outbreaks 11639:outbreaks 11517:Trans fat 11429:Olive oil 11351:Aflatoxin 11325:Sucralose 11310:Saccharin 11298:Aspartame 11242:Malathion 11187:Rotavirus 11182:Norovirus 10793:agonists: 10777:Enhancers 10650:Vesamicol 10534:Cymserine 10483:Obidoxime 10478:Methoxime 10392:Harmaline 10387:Cymserine 10377:Crimidine 10324:Unsorted: 10219:Triazofos 10159:Ro 3-0433 10154:Ro 3-0422 10149:Ro 3-0419 10144:Ro 3-0417 10139:Ro 3-0412 10134:Ro 3-0411 10129:Ro 3-0397 10124:Ro 3-0352 10119:Ro 3-0351 10114:Ro 3-0347 10109:Ro 3-0346 10104:Ro 3-0340 10094:Prothoate 10064:Phosfolan 10059:Phosalone 10044:Parathion 10029:Omethoate 9999:Mevinphos 9964:Malathion 9954:Leptophos 9859:Endothion 9739:Demephion 9729:Cyanophos 9719:Coumaphos 9689:Cadusafos 9684:Bensulide 9679:BAY-29952 9643:Zanapezil 9603:Minaprine 9583:Huprine Y 9578:Huprine X 9573:Huprine W 9543:Donepezil 9472:Thiofanox 9447:Promecarb 9437:Pinmicarb 9417:Metolcarb 9377:Dimetilan 9337:Bufencarb 9327:Aminocarb 9279:CM-54,903 9190:transport 8971:Adjuvants 8966:Sarolaner 8961:Pyriprole 8956:Pyridaben 8946:Lotilaner 8881:Bensultap 8845:Ryanodine 8782:Pyrethrum 8764:Pyrethrin 8581:Phosalone 8561:Parathion 8551:Omethoate 8531:Mevinphos 8516:Malathion 8431:Coumaphos 8406:Bensulide 8373:Toxaphene 8273:Chlordane 8167:Lufenuron 8061:Promecarb 8051:Metolcarb 7996:Aminocarb 7808:19 August 7782:19 August 7598:20 August 7470:28 August 7401:20 August 7371:15 August 7323:19 August 7272:18 August 7250:18 August 7229:18 August 7203:15 August 6800:28 August 6795:0362-4331 6714:210042328 6698:0163-7525 6474:14 August 6391:20 August 6386:0362-4331 6309:11 August 6260:1559-064X 6166:14 August 6039:0022-0949 5924:1932-6203 5503:0091-6765 5280:0003-4878 5221:1559-0631 5112:0091-6765 5055:0091-6765 4885:0165-3806 4831:0166-4328 4784:0009-2797 4716:0892-0362 4694:: 35โ€“42. 4651:0361-9230 4637:: 44โ€“54. 4594:0892-0362 4529:0300-483X 4459:1547-6898 4406:0009-2797 4351:0041-008X 4297:0009-8981 4206:0027-8874 4133:1073-449X 4081:0892-0362 4059:: 18โ€“27. 4019:0890-6238 3961:0887-8994 3851:0161-813X 3785:0160-4120 3717:0091-6765 3657:0091-6765 3603:ccceh.org 3573:0273-2300 3460:0378-4274 3280:1549-1277 3222:0140-6736 3134:1476-069X 3110:(1): 18. 3069:0140-6736 3015:1471-2458 2963:1460-2725 2771:0301-4797 2193:218928832 2177:0048-3575 1922:chemicals 1848:Australia 1831:waterways 1817:Clackamas 1767:Superfund 1757:Reporting 1735:steelhead 1430:June 2019 1422:talk page 1169:serotonin 1075:Adulthood 1014:Long term 958:Treatment 852:membranes 745:Synthesis 501:Mercaptan 158:2921-88-2 122:-Diethyl 45:talk page 11999:Cookbook 11979:Category 11781:E number 11673:outbreak 11630:outbreak 11621:outbreak 11371:Dieldrin 11320:Sorbitol 11176:Listeria 11116:Botulism 10944:Melamine 10914:Aldicarb 10833:See also 10817:Crotoxin 10519:Affinine 10452:BW284C51 10407:Lycorine 10337:Affinine 10327:ฮฑ-Pinene 10305:Onchidal 10224:Tribufos 10204:Terbufos 10174:Schradan 10039:Paraoxon 9959:Malaoxon 9889:Fenthion 9874:Ethoprop 9759:Diazinon 9754:Dialifor 9659:Acephate 9593:Itopride 9538:Caffeine 9462:Propoxur 9412:Methomyl 9342:Carbaryl 9322:Aldicarb 9141:Spinosad 9043:Paraoxon 9038:Malaoxon 9010:Xanthone 8985:Spinosad 8941:Limonene 8921:Fipronil 8850:Ryanodol 8822:Ryanoids 8636:Tribufos 8626:Terbufos 8611:Schradan 8501:Fenthion 8486:Ethoprop 8441:Diazinon 8391:Acephate 8328:Dieldrin 8263:Beta-HCH 8109:Cryolite 8066:Propoxur 8046:Methomyl 8011:Carbaryl 7991:Aldicarb 7691:6 August 7646:5 August 7620:5 August 7495:26 April 7419:. OEHHA. 6766:6 August 6706:31905321 6649:The Hill 6626:9 August 6601:30 March 6548:30 March 6525:30 March 6501:30 March 6278:32094458 6191:8 August 6186:IOL News 6112:pops.int 6057:23393272 5996:23386834 5942:24416121 5894:PLOS ONE 5875:24718419 5835:PLOS ONE 5811:5 August 5778:5 August 5751:11 April 5727:24723135 5585:5 August 5552:5 August 5521:27517732 5440:12460795 5339:21655147 5288:16984946 5239:19240759 5181:24705361 5130:18414640 5073:12003762 5002:"TOXNET" 4952:28 March 4916:(Report) 4893:14741763 4849:19682500 4792:20097188 4734:24177596 4669:24280657 4612:23416428 4572:: 1โ€“12. 4547:22884923 4475:84162223 4467:18726789 4424:18495101 4359:15236950 4305:16337171 4214:15572760 4141:11874814 4097:52925464 4089:30290195 4037:20850519 3969:18279750 3920:16115200 3912:16112323 3869:24121005 3803:28602489 3735:21507777 3675:21507776 3581:24200834 3468:22155227 3298:19564902 3238:10499125 3230:17174705 3186:21328273 3152:19379510 3085:13923877 3077:16243090 3033:18154668 2971:11077028 2838:22547821 2779:23176983 2747:Elsevier 2472:cite web 2352:31 March 2297:31 March 2261:Grainews 2185:32527435 2151:Elsevier 2057:(NIOSH). 1995:30 March 1953:See also 1932:Malaysia 1916:Thailand 1720:hydrates 1590:โ€”  1561:In 2007 1551:mosquito 1461:and the 1416:You may 1311:(1985), 1302:sediment 1231:nicotine 1069:diazinon 1065:lordosis 970:such as 964:atropine 834:Kinetics 757:(TCPy) ( 737:and the 691:, is an 563:Hazards 39:You may 11989:Commons 11862:(Spain) 11671:E. coli 11637:E. coli 11628:E. coli 11619:E. coli 11439:Seafood 11339:poisons 11237:Lindane 11201:E. coli 11160:O157:H7 11152:O104:H4 10954:Sudan I 10924:Cyanide 10803:Others: 10755:Others: 10691:SNAP-25 10664:Release 10554:Tacrine 10462:3152 CT 10427:Taspine 10199:Temefos 10099:R-16661 10069:Phosmet 10054:Phorate 10004:Mipafox 9969:Mazidox 9899:Fonofos 9844:EA-4352 9839:EA-3148 9834:EA-2613 9829:EA-2192 9824:EA-2098 9819:EA-2054 9814:EA-2012 9789:Dimefox 9744:Demeton 9638:Tacrine 9633:TL-1238 9553:EA-4056 9548:EA-3990 9457:Propham 9422:Miotine 8979:Sesamex 8871:Amitraz 8616:Temefos 8606:R-16661 8586:Phosmet 8576:Phorate 8536:Mipafox 8461:Dimefox 8353:Lindane 8323:Dicofol 8298:1,2-DCE 8293:1,1-DCE 8288:1,4-DCB 8283:1,2-DCB 7738:31 July 7572:11 June 7547:14 June 7521:14 June 7349:10 July 7297:23 July 7178:23 July 7131:23 July 7105:23 July 7075:23 July 7054:23 July 6980:23 July 6950:23 July 6909:23 July 6594:Reuters 6357:23 July 6331:21 July 6269:8075908 6092:21 July 6048:3641805 5987:3564010 5933:3885384 5902:Bibcode 5866:3981812 5843:Bibcode 5512:5332193 5431:1241103 5330:3108137 5230:3633453 5172:4025031 5121:2290988 5064:1240847 4986:8 April 4920:24 July 4840:2782724 4764:Bibcode 4725:3943881 4696:Bibcode 4660:3891922 4603:3669256 4574:Bibcode 4538:3516631 4509:Bibcode 4415:2582404 4386:Bibcode 4331:Bibcode 4249:7682805 4061:Bibcode 4028:3025269 3999:Bibcode 3892:Bibcode 3860:3899350 3831:Bibcode 3794:5533622 3765:Bibcode 3726:3237355 3666:3237357 3616:8 April 3289:2696321 3143:2673208 3112:Bibcode 3024:2262093 2829:3356641 2806:Bibcode 2751:Bibcode 2710:Bibcode 2637:24 July 2543:24 July 2436:1 April 2410:1 April 2381:1 April 2323:1 April 2267:1 April 2155:Bibcode 2118:1 April 2051:"#0137" 1864:Denmark 1773:(NRC). 1716:isomers 1672:residue 1666:Residue 1483:termite 1372:updated 1342:residue 1155:neurons 1147:synapse 1051:anxiety 896:fetuses 854:of the 814:foliage 807:almonds 761:) with 721:In the 662:what is 660: ( 545:2 mg/L 509:Density 293:PubChem 11444:Shrimp 11381:Dioxin 11335:Toxins 10909:3-MCPD 10164:Ronnel 10079:Phoxim 9869:Ethion 9664:Armine 9628:TL-599 9623:T-1194 9618:T-1152 9613:T-1123 9427:Oxamyl 9201:Enzyme 8891:Cartap 8591:Phoxim 8481:Ethion 8348:Kepone 8338:Endrin 8258:Aldrin 8056:Oxamyl 7875:30 May 7847:7 July 7345:. 1988 6887:30 May 6865:30 May 6793:  6741:2 July 6712:  6704:  6696:  6573:2 July 6384:  6276:  6266:  6258:  6055:  6045:  6037:  5994:  5984:  5970:: 13. 5940:  5930:  5922:  5873:  5863:  5725:  5715:  5519:  5509:  5501:  5438:  5428:  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