2032:
255:
232:
154:
129:
506:
261:
160:
4701:
Cargill M, Altshuler D, Ireland J, Sklar P, Ardlie K, Patil N, Shaw N, Lane CR, Lim EP, Kalyanaraman N, Nemesh J, Ziaugra L, Friedland L, Rolfe A, Warrington J, Lipshutz R, Daley GQ, Lander ES (1999). "Characterization of single-nucleotide polymorphisms in coding regions of human genes".
4628:
Sherrington R, Mankoo B, Attwood J, Kalsi G, Curtis D, Buetow K, Povey S, Gurling H (1994). "Cloning of the human dopamine D5 receptor gene and identification of a highly polymorphic microsatellite for the DRD5 locus that shows tight linkage to the chromosome 4p reference marker RAF1P1".
1686:
for it. There exist two types of the 148-bp allele of DRD5, a long and a short one. The short dinucleotide repeat allele is associated with ADHD, but not the long one. Another allele of DRD5 that is moderately associated with ADHD susceptibility is 150 bp. In a
3382:
Kim BN, Kang D, Cho SC, Park TW, Lim MH, Chung YC, Kim JW, Hwang JW, Yoo HJ, Chung US, Son JW, Yang JC, Chung SK, Lee JY, Jung YW (2009). "Shorter dinucleotide repeat length in the DRD5 gene is associated with attention deficit hyperactivity disorder".
4568:
Sobell JL, Lind TJ, Sigurdson DC, Zald DH, Snitz BE, Grove WM, Heston LL, Sommer SS (1995). "The D5 dopamine receptor gene in schizophrenia: identification of a nonsense change and multiple missense changes but lack of association with disease".
3645:
Muir WJ, Thomson ML, McKeon P, Mynett-Johnson L, Whitton C, Evans KL, Porteous DJ, Blackwood DH (2001). "Markers close to the dopamine D5 receptor gene (DRD5) show significant association with schizophrenia but not bipolar disorder".
4598:
Beischlag TV, Marchese A, Meador-Woodruff JH, Damask SP, O'Dowd BF, Tyndale RF, van Tol HH, Seeman P, Niznik HB (1995). "The human dopamine D5 receptor gene: cloning and characterization of the 5'-flanking and promoter region".
4030:
Mohr P, Decker M, Enzensperger C, Lehmann J (2006). "Dopamine/serotonin receptor ligands. 12(1): SAR studies on hexahydro-dibenzazecines lead to 4-chloro-7-methyl-5,6,7,8,9,14-hexahydrodibenzazecin-3-ol, the first picomolar
3346:
Sullivan PF, Neale MC, Silverman MA, Harris-Kerr C, Myakishev MV, Wormley B, Webb BT, Ma Y, Kendler KS, Straub RE (April 2001). "An association study of DRD5 with smoking initiation and progression to nicotine dependence".
1749:
reduces burst firing and improves motor deficits. Studies show that DRD5 T978C polymorphism is not associated with the susceptibility to PD, nor with the risk of developing motor fluctuations or hallucinations in PD.
4351:
Eubanks JH, Altherr M, Wagner-McPherson C, McPherson JD, Wasmuth JJ, Evans GA (1992). "Localization of the D5 dopamine receptor gene to human chromosome 4p15.1-p15.3, centromeric to the
Huntington's disease locus".
2752:
Eubanks JH, Altherr M, Wagner-McPherson C, McPherson JD, Wasmuth JJ, Evans GA (1992). "Localization of the D5 dopamine receptor gene to human chromosome 4p15.1-p15.3, centromeric to the
Huntington's disease locus".
3461:
Medin T, Rinholm JE, Owe SG, Sagvolden T, Gjedde A, Storm-Mathisen J, Bergersen LH (2013). "Low dopamine D5 receptor density in hippocampus in an animal model of attention-deficit/hyperactivity disorder (ADHD)".
4381:
Sunahara RK, Guan HC, O'Dowd BF, Seeman P, Laurier LG, Ng G, George SR, Torchia J, Van Tol HH, Niznik HB (1991). "Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1".
2390:
Sunahara RK, Guan HC, O'Dowd BF, Seeman P, Laurier LG, Ng G, George SR, Torchia J, Van Tol HH, Niznik HB (1991). "Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1".
268:
167:
1663:, have been suggested to play a role in the initiation of smoking. In a study on the association of four polymorphisms of this gene with smoking, a statistical analysis suggested that there may exist a
4429:"Cloning, molecular characterization, and chromosomal assignment of a gene encoding a second D1 dopamine receptor subtype: differential expression pattern in rat brain compared with the D1A receptor"
3418:
Squassina A, Lanktree M, De Luca V, Jain U, Krinsky M, Kennedy JL, Muglia P (2008). "Investigation of the dopamine D5 receptor gene (DRD5) in adult attention deficit hyperactivity disorder".
1940:
receptors have a high degree of structural homology and few ligands are available that can distinguish between them as yet. However, there is a number of ligands that are selective for D
3784:
Hollon TR, Bek MJ, Lachowicz JE, Ariano MA, Mezey E, Ramachandran R, Wersinger SR, Soares-da-Silva P, Liu ZF, Grinberg A, Drago J, Young WS, Westphal H, Jose PA, Sibley DR (2002).
4739:
Liu F, Wan Q, Pristupa ZB, Yu XM, Wang YT, Niznik HB (2000). "Direct protein–protein coupling enables cross-talk between dopamine D5 and gamma-aminobutyric acid A receptors".
4154:
Liu F, Wan Q, Pristupa ZB, Yu XM, Wang YT, Niznik HB (2000). "Direct protein–protein coupling enables cross-talk between dopamine D5 and gamma-aminobutyric acid A receptors".
3559:
Wang J, Liu ZL, Chen B (July 2001). "Dopamine D5 receptor gene polymorphism and the risk of levodopa-induced motor fluctuations in patients with
Parkinson's disease".
3510:"Inhibiting subthalamic D5 receptor constitutive activity alleviates abnormal electrical activity and reverses motor impairment in a rat model of Parkinson's disease"
7770:
4072:"Calcium signaling by dopamine D5 receptor and D5-D2 receptor hetero-oligomers occurs by a mechanism distinct from that for dopamine D1-D2 receptor hetero-oligomers"
4784:
Misbahuddin A, Placzek MR, Chaudhuri KR, Wood NW, Bhatia KP, Warner TT (2004). "A polymorphism in the dopamine receptor DRD5 is associated with blepharospasm".
5024:
2948:
Miyazaki I, Asanuma M, Diaz-Corrales FJ, Miyoshi K, Ogawa N (2004). "Direct evidence for expression of dopamine receptors in astrocytes from basal ganglia".
854:
90:
1682:
in humans. 136-bp allele of the gene was shown to be a protective factor against developing this disorder, and 148-bp allele of DRD5 was shown to be a
835:
4205:
Missale C, Fiorentini C, Collo G, Spano P (2010). "The neurobiology of dopamine receptors: Evolution from the dual concept to heterodimer complexes".
7236:
3602:
Wang J, Zhao C, Chen B, Liu Z (January 2004). "Polymorphisms of dopamine receptor and transporter genes and hallucinations in
Parkinson's disease".
4952:
6174:
6376:
6371:
6366:
6361:
2328:
2310:
7106:
2485:
Mello, F. G. (October 1978). "The
Ontogeny of Dopamine-Dependent Increase of Adenosine 3',5'-Cyclic Monophosphate in the Chick Retina".
7496:
7491:
4992:
4119:
Ulfers AL, McMurry JL, Kendall DA, Mierke DF (2002). "Structure of the third intracellular loop of the human cannabinoid 1 receptor".
7527:
6872:
5017:
1061:
7487:
6273:
6268:
1679:
1541:
receptor participates in the synaptic processes that underlie learning and memory. These receptors participate in the formation of
1340:
receptor exist that share 98% sequence with each other and 95% sequence with the functional DRD5 gene. These genes contain several
1054:
4322:
Grandy DK, Allen LJ, Zhang Y, Magenis RE, Civelli O (1992). "Chromosomal localization of three human D5 dopamine receptor genes".
3138:
Centonze D, Grande C, Saulle E, Martin AB, Gubellini P, Pavón N, Pisani A, Bernardi G, Moratalla R, Calabresi P (September 2003).
7511:
7193:
7188:
7183:
6149:
2161:
receptors and their affinity for drugs with similar pharmacological profile complicate distinguishing between them in research.
7567:
6437:
6264:
3659:
7178:
6124:
2293:
7931:
6352:
6164:
5634:
5372:
5367:
5362:
5357:
5352:
5010:
4427:
Tiberi M, Jarvie KR, Silvia C, Falardeau P, Gingrich JA, Godinot N, Bertrand L, Yang-Feng TL, Fremeau RT, Caron MG (1991).
3508:
Chetrit J, Taupignon A, Froux L, Morin S, Bouali-Benazzouz R, Naudet F, Kadiri N, Gross CE, Bioulac B, Benazzouz A (2013).
1834:
receptors that are expressed in kidneys are also involved in the regulation of blood pressure via modulating expression of
1570:
7165:
5814:
2607:"A physiological role for the dopamine D5 receptor as a regulator of BDNF and Akt signalling in rodent prefrontal cortex"
2272:
3876:
Prado C, Contreras F, González H, Díaz P, Elgueta D, Barrientos M, Herrada AA, Lladser Á, Bernales S, Pacheco R (2012).
7070:
6039:
3089:
Wang S, Lu X, Yang J, Wang H, Chen C, Han Y, Ren H, Zheng S, He D, Zhou L, Asico LD, Wang WE, Jose PA, Zeng C (2014).
7739:
7734:
7729:
7724:
7719:
7714:
7709:
7704:
5927:
5722:
5717:
5712:
5348:
2899:"Regional, cellular, and subcellular variations in the distribution of D1 and D5 dopamine receptors in primate brain"
1237:
3980:"(-)-Stepholidine is a potent pan-dopamine receptor antagonist of both G protein- and β-arrestin-mediated signaling"
254:
7521:
7516:
6456:
6451:
5532:
5527:
7700:
7607:
6461:
5707:
5462:
2841:
2297:
2276:
2138:
2031:
1763:
231:
3683:"Relationship between genetic polymorphisms in the DRD5 gene and paranoid schizophrenia in northern Han Chinese"
7556:
7551:
7085:
6326:
6321:
6169:
6018:
6013:
3724:"Methamphetamine increases locomotion and dopamine transporter activity in dopamine d5 receptor-deficient mice"
1505:
1178:
899:
7090:
4293:
Missale C, Nash SR, Robinson SW, Jaber M, Caron MG (1998). "Dopamine receptors: from structure to function".
2797:
Wu J, Xiao H, Sun H, Zou L, Zhu LQ (2012). "Role of dopamine receptors in ADHD: A systematic meta-analysis".
1613:, deactivation of these channels leads to increased neuronal excitability and enhanced memory consolidation.
4480:
Grandy DK, Zhang YA, Bouvier C, Zhou QY, Johnson RA, Allen L, Buck K, Bunzow JR, Salon J, Civelli O (1991).
2541:
Grandy DK, Zhang YA, Bouvier C, Zhou QY, Johnson RA, Allen L, Buck K, Bunzow JR, Salon J, Civelli O (1991).
880:
7547:
5887:
5882:
5118:
5113:
5108:
5098:
5093:
5088:
1221:
receptors were able to stimulate biphasic accumulation of cAMP under the same conditions, suggesting that D
153:
128:
70:
4535:"Molecular cloning and characterization of a high affinity dopamine receptor (D1 beta) and its pseudogene"
2024:
4-Chloro-7-methyl-5,6,7,8,9,14-hexahydrodibenzazecin-3-ol: antagonist, moderate binding selectivity over D
7936:
7081:
5648:
5643:
5104:
5084:
2991:
Prado C, Bernales S, Pacheco R (2013). "Modulation of T-cell mediated immunity by dopamine receptor d5".
2442:
Beaulieu JM, Gainetdinov RR (2011). "The physiology, signaling, and pharmacology of dopamine receptors".
17:
3837:"Dopamine inhibits the effector functions of activated NK cells via the upregulation of the D5 receptor"
1162:
receptor is a subtype of the dopamine receptor that has a 10-fold higher affinity for dopamine than the
6081:
6076:
5932:
5922:
5917:
5902:
5897:
5870:
5696:
5691:
5686:
5597:
5134:
5129:
5124:
5037:
4964:
1827:
1590:
1582:
1501:
1210:
1174:
267:
166:
680:
norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure
6118:
6113:
6108:
5878:
5764:
5592:
5574:
5555:
5548:
5067:
5002:
4823:"Interaction with neuronal calcium sensor NCS-1 mediates desensitization of the D2 dopamine receptor"
3878:"Stimulation of dopamine receptor D5 expressed on dendritic cells potentiates Th17-mediated immunity"
1890:
260:
159:
3289:"Differential roles of the dopamine 1-class receptors, D1R and D5R, in hippocampal dependent memory"
2659:"High agonist-independent activity is a distinguishing feature of the dopamine D1B receptor subtype"
57:
7673:
7542:
7502:
7148:
6072:
6034:
5893:
5682:
5606:
5560:
5050:
4983:
4660:"Multiple coupling of human D5 dopamine receptors to guanine nucleotide binding proteins Gs and Gz"
3978:
Meade JA, Free RB, Miller NR, Chun LS, Doyle TB, Moritz AE, Conroy JL, Watts VJ, Sibley DR (2014).
3140:"Distinct roles of D1 and D5 dopamine receptors in motor activity and striatal synaptic plasticity"
2842:"Variability in neuronal expression of dopamine receptors and transporters in the substantia nigra"
78:
4250:"Conditional inactivation of the dopamine receptor 5 gene: Flanking the Drd5 gene with loxP sites"
6406:
6401:
6396:
6391:
6386:
6346:
6341:
6258:
6253:
6248:
6238:
6104:
5988:
5956:
5951:
5913:
5908:
5819:
5543:
4979:
3196:"M1-muscarinic receptors promote fear memory consolidation via phospholipase C and the M-current"
1766:
in this gene, including changes in rs77434921, rs1800762, rs77434921, and rs1800762, in northern
1037:
1016:
990:
969:
6059:
6054:
5971:
5966:
5565:
5166:
5161:
3835:
Mikulak J, Bozzo L, Roberto A, Pontarini E, Tentorio P, Hudspeth K, Lugli E, Mavilio D (2014).
3091:"Regulation of renalase expression by D5 dopamine receptors in rat renal proximal tubule cells"
1738:
1656:
1621:
1558:
1365:
2177:
were obtained from third extracellular loop and third intracellular loop of the receptor, and
7604:
6442:
6426:
6421:
6416:
6382:
6337:
6234:
6097:
6092:
6044:
5947:
5942:
5729:
5613:
5456:
5451:
5446:
5435:
5430:
5425:
5420:
5171:
5156:
5033:
3722:
Hayashizaki S, Hirai S, Ito Y, Honda Y, Arime Y, Sora I, Okado H, Kodama T, Takada M (2013).
2221:
2190:
1305:, accounting for 26% of the entire protein. In spite of the high degree of homology between D
1866:
receptors was shown to be upregulated in NK cells in response to prolonged stimulation with
7654:
7312:
6624:
6447:
6432:
6009:
5962:
5639:
5618:
5398:
5393:
5388:
5383:
4748:
4493:
4440:
4391:
4163:
3735:
3300:
2554:
2400:
2170:
2064:
1598:
1586:
1550:
1542:
1369:
1329:
1310:
1283:
1163:
1143:
142:
6298:
6293:
6288:
98:
8:
7477:
6412:
6303:
6087:
6050:
5515:
5144:
5076:
3786:"Mice lacking D5 dopamine receptors have increased sympathetic tone and are hypertensive"
1859:
1730:
1710:
1444:
4911:"Galpha12- and Galpha13-protein subunit linkage of D5 dopamine receptors in the nephron"
4752:
4676:
4659:
4497:
4444:
4395:
4167:
3739:
3304:
2558:
2404:
7696:
7207:
7031:
6143:
6138:
6133:
6067:
5442:
5415:
5152:
4927:
4910:
4892:
4867:
4849:
4839:
4822:
4809:
4772:
4727:
4689:
4415:
4230:
4187:
4096:
4071:
4004:
3979:
3955:
3918:
3812:
3802:
3785:
3758:
3723:
3627:
3584:
3536:
3509:
3487:
3475:
3443:
3323:
3288:
3245:"KCNQ5, a novel potassium channel broadly expressed in brain, mediates M-type currents"
3220:
3195:
3166:
3156:
3139:
3115:
3090:
2973:
2925:
2915:
2898:
2879:
2822:
2729:
2704:
2631:
2606:
2518:
2498:
2467:
2424:
2165:
these two receptors separately is suggested to be inefficient. However, expression of D
1921:
1874:
1279:
102:
4551:
4534:
4482:"Multiple human D5 dopamine receptor genes: a functional receptor and two pseudogenes"
3572:
2675:
2658:
2543:"Multiple human D5 dopamine receptor genes: a functional receptor and two pseudogenes"
769:
764:
759:
754:
749:
744:
739:
734:
729:
724:
719:
714:
709:
704:
699:
694:
689:
684:
679:
674:
669:
664:
659:
654:
649:
644:
628:
623:
618:
613:
608:
603:
598:
593:
588:
572:
567:
562:
552:
547:
7562:
7506:
7152:
6882:
6877:
6332:
6029:
5378:
4932:
4897:
4854:
4801:
4764:
4731:
4719:
4681:
4646:
4616:
4586:
4556:
4521:
4516:
4481:
4468:
4463:
4428:
4407:
4369:
4365:
4339:
4335:
4310:
4271:
4222:
4179:
4136:
4101:
4052:
4009:
3960:
3899:
3858:
3817:
3763:
3704:
3663:
3619:
3576:
3541:
3479:
3435:
3400:
3364:
3328:
3266:
3225:
3171:
3120:
3062:
3018:
2965:
2930:
2871:
2814:
2770:
2766:
2734:
2680:
2636:
2582:
2577:
2542:
2510:
2502:
2459:
2416:
2367:
2363:
2249:
2072:
1967:
receptors show higher affinity for agonists and lower affinity for antagonists than D
1802:
mice, which suggests that these receptors have a role in controlling motor activity.
1787:
1249:
50:
4813:
4693:
4234:
3631:
3588:
3491:
2977:
2883:
2522:
6357:
6279:
6129:
4922:
4887:
4879:
4844:
4834:
4793:
4776:
4756:
4711:
4671:
4638:
4608:
4578:
4546:
4511:
4501:
4458:
4448:
4419:
4399:
4361:
4331:
4302:
4261:
4214:
4191:
4171:
4128:
4091:
4083:
4044:
3999:
3991:
3950:
3942:
3889:
3848:
3807:
3797:
3753:
3743:
3694:
3655:
3611:
3568:
3531:
3526:
3521:
3471:
3447:
3427:
3392:
3356:
3318:
3308:
3256:
3215:
3211:
3207:
3161:
3151:
3110:
3102:
3052:
3008:
3000:
2961:
2957:
2920:
2910:
2861:
2853:
2806:
2762:
2724:
2716:
2670:
2626:
2618:
2572:
2562:
2494:
2471:
2451:
2428:
2408:
2359:
2076:
1905:
1855:
1610:
1290:
1245:
1202:
1186:
1182:
1135:
347:
278:
222:
177:
4306:
2826:
82:
7750:
7537:
7346:
6635:
6317:
6284:
6024:
5321:
5306:
5301:
5296:
5286:
5281:
5276:
5271:
5266:
4218:
3748:
3615:
3431:
3396:
2237:
2080:
1867:
1795:
1594:
1509:
1397:
1241:
322:
106:
4070:
So CH, Verma V, Alijaniaram M, Cheng R, Rashid AJ, O'Dowd BF, George SR (2009).
3106:
3004:
2333:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2315:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1762:. The 148 bp allele of DRD5 was linked to increased risk of schizophrenia. Some
1758:
Several polymorphisms in DRD5 genes have been associated with susceptibility to
7623:
6483:
6311:
5538:
5331:
5326:
5316:
5292:
5262:
5257:
2897:
Bergson C, Mrzljak L, Smiley JF, Pappy M, Levenson R, Goldman-Rakic PS (1995).
2720:
2162:
1917:
1913:
1823:
1815:
1699:
1629:
1473:
1440:
1377:
423:
4909:
Zheng S, Yu P, Zeng C, Wang Z, Yang Z, Andrews PM, Felder RA, Jose PA (2003).
3995:
2810:
2622:
1814:
receptor may be involved in modulation of the neuronal pathways that regulate
7925:
7678:
7327:
7322:
7317:
6243:
6179:
5247:
4996:
3894:
3877:
3853:
3836:
3699:
3682:
2506:
2205:
2186:
2107:
2071:. Co-activation of these receptors within the heteromer triggers increase in
1980:
1909:
1870:
1842:, and disturbance of these processes can contribute to hypertension as well.
1759:
1675:
1633:
1477:
1466:
1341:
1262:
receptors show high constitutive activity that is independent of binding any
534:
4506:
4453:
3313:
3057:
3040:
2567:
2039:-preferring ligand 4-chloro-7-methyl-5,6,7,8,9,14-hexahydrodibenzazecin-3-ol
557:
483:
361:
7600:
5998:
5992:
5602:
5587:
5410:
5177:
4936:
4901:
4858:
4805:
4768:
4723:
4642:
4275:
4226:
4183:
4140:
4105:
4087:
4056:
4013:
3964:
3903:
3862:
3821:
3767:
3708:
3667:
3623:
3580:
3545:
3483:
3439:
3404:
3368:
3332:
3270:
3261:
3244:
3229:
3175:
3124:
3022:
2969:
2875:
2818:
2738:
2640:
2463:
2217:
2193:
has been developed, which allowed to separately examine the expression of D
1995:
1819:
1688:
1521:
1393:
505:
340:
119:
4868:"Neuron-specific age-related decreases in dopamine receptor subtype mRNAs"
4685:
4650:
4620:
4590:
4582:
4560:
4533:
Weinshank RL, Adham N, Macchi M, Olsen MA, Branchek TA, Hartig PR (1991).
4525:
4472:
4411:
4373:
4343:
4314:
3066:
2934:
2774:
2705:"D5 dopamine receptor carboxyl tail involved in D5-D2 heteromer formation"
2684:
2586:
2455:
2420:
2371:
1944:
over the other dopamine receptors. The recent development of a selective D
1101:
4797:
3243:
Schroeder BC, Hechenberger M, Weinreich F, Kubisch C, Jentsch TJ (2000).
2514:
2182:
2012:
1767:
1746:
1734:
1696:
1683:
1640:
1565:
receptors are also associated with the consolidation of fear memories in
1420:
1417:
1413:
1381:
944:
925:
675:
adenylate cyclase-activating G protein-coupled receptor signaling pathway
4963:. International Union of Basic and Clinical Pharmacology. Archived from
4612:
3013:
2866:
2122:
receptors can be disrupted through changes of single amino acids in the
1096:
7902:
7818:
7045:
4350:
4266:
4249:
2751:
2123:
2104:
2000:
1990:
1985:
1702:
1448:
1428:
1401:
1344:
1333:
1302:
1298:
239:
136:
86:
5032:
4883:
4597:
4132:
4048:
3946:
3660:
10.1002/1096-8628(2001)9999:9999<::AID-AJMG1163>3.0.CO;2-2
3360:
2857:
7611:
7532:
5054:
4760:
4403:
4175:
3242:
2412:
2178:
2060:
2044:
1886:
1799:
1783:
1664:
1606:
1601:. One effect of the activation of phospholipase C is deactivation of
1459:
799:
306:
293:
205:
192:
94:
2604:
2347:
7836:
7814:
3595:
2947:
2209:
2096:
1835:
1726:
1566:
1546:
1517:
1456:
1436:
1432:
1405:
1389:
1385:
1373:
1255:
1225:
receptors may use a different system of secondary messengers than D
1214:
1085:
4821:
Kabbani N, Negyessy L, Lin R, Goldman-Rakic P, Levenson R (2002).
4715:
3287:
Sariñana J, Kitamura T, Künzler P, Sultzman L, Tonegawa S (2014).
6907:
6617:
6612:
6607:
6602:
6597:
6592:
6587:
6582:
6577:
6572:
6567:
6562:
6557:
6552:
6547:
6542:
6537:
6532:
6228:
6223:
6218:
6213:
3345:
2174:
2084:
1877:
of the NK cells and suppresses synthesis of IFNγ. Activation of D
1637:
1625:
1347:
that prevent these genes from transcribing a functional protein.
1263:
1124:
911:
866:
784:
780:
665:
adenylate cyclase-activating dopamine receptor signaling pathway
74:
7789:
7784:
7779:
7774:
7764:
7759:
7754:
7745:
7690:
7685:
7647:
7642:
7637:
7599:
7482:
7458:
7453:
7448:
7443:
7438:
7433:
7428:
7423:
7418:
7413:
7408:
7403:
7398:
7393:
7388:
7383:
7378:
7300:
7295:
7290:
7285:
7222:
7217:
7212:
7120:
7065:
7060:
7055:
7026:
7007:
7002:
6997:
6992:
6987:
6982:
6977:
6972:
6967:
6962:
6957:
6952:
6947:
6942:
6937:
6932:
6927:
6922:
6917:
6912:
6902:
6897:
6892:
6887:
6867:
6527:
6522:
6517:
6512:
6507:
6502:
6497:
6208:
6203:
6198:
6193:
6158:
5849:
5672:
5666:
5236:
5231:
5221:
5216:
4820:
4783:
4248:
Heyer J, Xiao Q, Bugaj-Gaweda B, Ramboz S, Unterbeck A (2002).
3644:
3286:
2142:
1908:. Specifically, these receptors play a role in polarization of
1839:
1497:
1493:
1069:
821:
514:
740:
phospholipase C-activating dopamine receptor signaling pathway
7885:
7576:
7571:
7373:
7368:
7363:
7358:
7334:
7280:
7275:
7270:
7115:
7110:
7100:
7095:
7036:
6862:
6857:
6852:
6847:
6842:
6837:
6832:
6827:
6822:
6817:
6812:
6807:
6802:
6797:
6792:
6787:
6782:
6777:
6772:
6767:
6762:
6757:
6752:
6747:
6742:
6737:
6732:
6727:
6722:
6717:
6712:
6707:
6702:
6697:
6692:
6687:
6682:
6677:
6672:
6667:
6188:
6153:
6003:
5843:
5838:
5833:
5828:
5823:
5809:
5803:
5798:
5793:
5788:
5783:
5778:
5773:
5768:
5758:
5753:
5748:
5743:
5738:
5733:
5701:
5661:
5656:
5579:
5491:
5486:
5481:
5476:
5471:
5466:
5226:
5211:
5206:
5201:
5196:
5191:
5186:
5181:
4627:
4029:
1882:
1794:
receptors show increased motor response to administration of
1602:
700:
regulation of systemic arterial blood pressure by vasopressin
4700:
4380:
3834:
3552:
3417:
2389:
2348:"The human D5 dopamine receptor (DRD5) maps on chromosome 4"
2224:, allowing to generate tissue or animal lacking functional D
1904:
receptors are involved in activation and differentiation of
7880:
7875:
7870:
7865:
7860:
7855:
7850:
7845:
7840:
7258:
7251:
7246:
7241:
7050:
7040:
6662:
6657:
6652:
6647:
6307:
6183:
5677:
4426:
4247:
4204:
2840:
Reyes S, Cottam V, Kirik D, Double KL, Halliday GM (2013).
1894:
1516:
receptors are thought to positively regulate expression of
1131:
568:
dopamine neurotransmitter receptor activity, coupled via Gs
7812:
4118:
3875:
3507:
3137:
2605:
Perreault ML, Jones-Tabah J, O'Dowd BF, George SR (2013).
1667:
of DRD5 that is protective against initiation of smoking.
1316:
receptors, their c-terminus tails have little similarity.
7075:
4532:
3916:
2896:
1520:. Their faulty functioning in nephrons can contribute to
1463:
4865:
4292:
3783:
3721:
3460:
2993:
Endocrine, Metabolic & Immune
Disorders Drug Targets
2702:
2345:
330:
4567:
4321:
4069:
1952:-mediated responses to be studied in the absence of a D
1897:
of IFNγ, the expression of IFNγ protein is diminished.
4479:
2839:
2540:
1912:
into the T helper 17 cells by modulating secretion of
1332:. The gene lacks introns and encodes a product of 477
1782:
receptor is believed to participate in modulation of
495:
2990:
2611:
1818:. Mice lacking this receptor in their brains showed
1472:
The receptors of this subtype are also expressed on
1412:
is exclusively expressed by large aspiny neurons in
4658:Sidhu A, Kimura K, Uh M, White BH, Patel S (1998).
3977:
2709:
2698:
2696:
2694:
2441:
2346:Polymeropoulos MH, Xiao H, Merril CR (March 1992).
2181:were developed for staining the receptor in frozen
1659:
in the DRD5 gene, which encodes dopamine receptor D
450:
dentate gyrus of hippocampal formation granule cell
4657:
3041:"Renal dopamine receptor function in hypertension"
3038:
2289:
2287:
2285:
2268:
2266:
2264:
1504:, and their activation suppresses the activity of
770:positive regulation of adenylate cyclase activity
277:
176:
7923:
4738:
4153:
3917:Wood M, Dubois V, Scheller D, Gillard M (2014).
2691:
4908:
4025:
4023:
3779:
3777:
3681:Zhao Y, Ding M, Pang H, Xu XM, Wang BJ (2014).
3601:
3293:Proceedings of the National Academy of Sciences
2282:
2261:
2050:
1805:
725:negative regulation of NAD(P)H oxidase activity
4866:Hemby SE, Trojanowski JQ, Ginsberg SD (2003).
3680:
3381:
3088:
2294:GRCm38: Ensembl release 89: ENSMUSG00000039358
2208:mice can be obtained by crossing 129/SvJ1 and
5018:
4961:IUPHAR Database of Receptors and Ion Channels
3919:"Rotigotine is a potent agonist at dopamine D
2703:O'Dowd BF, Nguyen T, Ji X, George SR (2013).
1589:cued fear memory. It is suggested that these
1209:receptors were shown to stimulate monophasic
4207:Journal of Receptors and Signal Transduction
4147:
4020:
3774:
2796:
2536:
2534:
2532:
2083:, as well as on the influx of extracellular
1854:receptors negatively regulate production of
1236:receptors is shown to promote expression of
765:G protein-coupled receptor signaling pathway
5049:
3558:
3282:
3280:
3193:
2656:
2435:
2273:GRCh38: Ensembl release 89: ENSG00000169676
650:cellular response to catecholamine stimulus
553:dopamine neurotransmitter receptor activity
61:, DBDR, DRD1B, DRD1L2, dopamine receptor D5
7147:
5025:
5011:
4993:United States National Library of Medicine
4035:-selective dopamine-receptor antagonist".
2385:
2383:
2381:
2339:
1826:, which may have been caused by increased
4982:at the U.S. National Library of Medicine
4926:
4891:
4848:
4838:
4675:
4550:
4515:
4505:
4462:
4452:
4265:
4095:
4003:
3954:
3893:
3852:
3828:
3811:
3801:
3757:
3747:
3698:
3535:
3525:
3322:
3312:
3260:
3219:
3165:
3155:
3114:
3084:
3082:
3080:
3078:
3076:
3056:
3034:
3032:
3012:
2924:
2914:
2865:
2792:
2790:
2788:
2786:
2784:
2728:
2674:
2630:
2576:
2566:
2529:
2075:. This calcium signaling is dependent on
1435:. They are also sometimes located in the
1364:receptor is expressed more widely in the
1355:
735:reactive oxygen species metabolic process
4991:This article incorporates text from the
3277:
2030:
1527:
730:activation of adenylate cyclase activity
3339:
3189:
3187:
3185:
2652:
2650:
2600:
2598:
2596:
2378:
2216:receptor can also be inactivated in an
2148:
1427:receptors are found on the membrane of
1319:
14:
7924:
6175:Luteinizing hormone/choriogonadotropin
3073:
3029:
2984:
2890:
2781:
1948:antagonist has allowed the action of D
1716:
1532:
1512:, preventing reabsorption of sodium. D
7811:
7598:
7179:Brain-specific angiogenesis inhibitor
7146:
5048:
5006:
3503:
3501:
2941:
2484:
2153:The high degree of homology between D
1741:. In this animal model, blockage of D
685:negative regulation of blood pressure
604:integral component of plasma membrane
282:
243:
238:
181:
140:
135:
3648:American Journal of Medical Genetics
3182:
2647:
2593:
2099:in ic3 (third cytoplasmic loop) of D
1269:
1213:accumulation of cAMP in response to
4677:10.1046/j.1471-4159.1998.70062459.x
2006:
760:synaptic transmission, dopaminergic
548:G protein-coupled receptor activity
24:
4928:10.1161/01.HYP.0000057422.75590.D7
4840:10.1523/JNEUROSCI.22-19-08476.2002
4285:
3923:receptors as well as at dopamine D
3803:10.1523/JNEUROSCI.22-24-10801.2002
3498:
3476:10.1016/j.neuroscience.2013.03.036
3157:10.1523/JNEUROSCI.23-24-08506.2003
3039:Hussain T, Lokhandwala MF (1998).
2916:10.1523/JNEUROSCI.15-12-07821.1995
2499:10.1111/j.1471-4159.1978.tb00146.x
2169:receptors has been assessed using
1713:that may be associated with ADHD.
1557:involvement with the formation of
1496:and are involved in regulation of
1368:than its close structural homolog
624:intracellular anatomical structure
25:
7948:
4945:
2095:receptors are formed by adjacent
1678:of DRD5 gene are associated with
1416:of primates, which are typically
1238:brain-derived neurotrophic factor
1127:that in humans is encoded by the
7528:Growth-hormone-releasing hormone
2059:receptor has been shown to form
1920:in response to stimulation with
1753:
710:cellular calcium ion homeostasis
655:regulation of female receptivity
504:
266:
259:
253:
230:
165:
158:
152:
127:
7488:Corticotropin-releasing hormone
4241:
4198:
4112:
4063:
3971:
3935:British Journal of Pharmacology
3910:
3869:
3715:
3687:Genetics and Molecular Research
3674:
3638:
3454:
3411:
3375:
3249:Journal of Biological Chemistry
3236:
3131:
2833:
2745:
2220:by flanking the DRD5 gene with
1764:single-nucleotide polymorphisms
1500:excretion. They are located on
573:G-protein alpha-subunit binding
6150:Gonadotropin-releasing hormone
3527:10.1523/JNEUROSCI.0453-13.2013
3212:10.1523/JNEUROSCI.1040-13.2014
2962:10.1016/j.brainres.2004.09.014
2478:
2321:
2303:
2228:receptors. The expression of D
2201:receptors in the mouse brain.
2114:receptor. Heteromerization of
2018:
1620:receptors may be required for
1609:that raises the threshold for
1605:. Since KCNQ channels conduct
1177:, which promotes synthesis of
755:chemical synaptic transmission
589:integral component of membrane
515:More reference expression data
484:More reference expression data
13:
1:
7568:Vasoactive intestinal peptide
6438:Thyrotropin-releasing hormone
4552:10.1016/S0021-9258(18)54590-7
4307:10.1152/physrev.1998.78.1.189
3573:10.1016/S0304-3940(01)01971-1
2676:10.1016/S0021-9258(18)46876-7
2255:
1956:component, but no selective D
1873:. This upregulation inhibits
1773:
1725:receptors may be involved in
1350:
690:transmission of nerve impulse
251:
150:
27:Protein-coding gene in humans
4486:Proc. Natl. Acad. Sci. U.S.A
4433:Proc. Natl. Acad. Sci. U.S.A
4366:10.1016/0888-7543(92)90442-U
4336:10.1016/0888-7543(92)90009-H
4219:10.3109/10799893.2010.506192
3749:10.1371/journal.pone.0075975
3616:10.1016/j.neulet.2003.11.006
3432:10.1016/j.neulet.2007.12.003
3397:10.1097/YPG.0b013e328320803c
3194:Young MB, Thomas SA (2014).
2767:10.1016/0888-7543(92)90442-u
2547:Proc. Natl. Acad. Sci. U.S.A
2364:10.1016/0888-7543(91)90091-R
2103:receptor and three adjacent
2051:Protein–protein interactions
1960:agonists are yet available.
1887:repressing the transcription
1806:Regulation of blood pressure
1709:receptors may contribute to
1646:
1372:. It is found in neurons in
7:
7932:Genes on human chromosome 4
6353:Prolactin-releasing peptide
5038:G protein-coupled receptors
3790:The Journal of Neuroscience
3144:The Journal of Neuroscience
3107:10.1152/ajprenal.00196.2013
3005:10.2174/1871530311313020007
2903:The Journal of Neuroscience
2657:Tiberi M, Caron MG (1994).
2243:
2236:can also be silenced using
2185:tissue. A method involving
1974:
1893:. Because miRNA29a targets
1845:
1591:G protein-coupled receptors
1583:beta-2 adrenergic receptors
1561:in the same brain region. D
1549:, which is opposite to the
1502:proximal convoluted tubules
1492:receptors are expressed in
1328:receptor is encoded on the
1293:are 49% to 80% identical. D
1153:
10:
7953:
2721:10.1016/j.bbrc.2012.12.139
2238:antisense oligonucleotides
1927:
1651:
1506:sodium–hydrogen antiporter
1455:receptor is also found in
1175:G-protein coupled receptor
558:signal transducer activity
7895:
7829:
7825:
7807:
7664:
7622:
7618:
7594:
7468:
7345:
7164:
7160:
7142:
7017:
6634:
6482:
6475:
5981:
5869:
5862:
5627:
5514:
5505:
5341:
5246:
5143:
5075:
5066:
5062:
5044:
3996:10.1007/s00213-014-3726-8
3882:The Journal of Immunology
3841:The Journal of Immunology
2811:10.1007/s12035-012-8278-5
2623:10.1017/S1461145712000685
2487:Journal of Neurochemistry
2329:"Mouse PubMed Reference:"
2311:"Human PubMed Reference:"
2173:. In this technique, two
2035:Chemical structure of a D
1691:of ADHD, low density of D
1569:. It has been shown that
1483:
1100:
1095:
1091:
1084:
1068:
1049:
1034:
1030:
1013:
1009:
1002:
987:
983:
966:
962:
955:
942:
938:
923:
919:
910:
897:
893:
878:
874:
865:
852:
848:
833:
829:
820:
805:
798:
794:
778:
533:
529:
512:
503:
494:
481:
470:glossopharyngeal ganglion
430:
421:
388:anterior cingulate cortex
368:
359:
329:
321:
317:
300:
287:
250:
229:
220:
216:
199:
186:
149:
126:
117:
113:
68:
65:
55:
48:
43:
39:
34:
7674:Calcium-sensing receptor
7543:Methuselah-like proteins
4984:Medical Subject Headings
3895:10.4049/jimmunol.1103096
3854:10.4049/jimmunol.1401114
3700:10.4238/2014.March.12.13
376:tibialis anterior muscle
5820:Sphingosine-1-phosphate
5708:Hydroxycarboxylic acids
4507:10.1073/pnas.88.20.9175
4454:10.1073/pnas.88.17.7491
3514:Journal of Neuroscience
3314:10.1073/pnas.1407395111
3200:Journal of Neuroscience
3058:10.1161/01.hyp.32.2.187
2568:10.1073/pnas.88.20.9175
2077:Gq-11 protein signaling
1670:
1336:. Two pseudogenes for D
1330:chromosome 4p15.1–p15.3
1062:Chr 5: 38.48 – 38.48 Mb
695:response to amphetamine
466:ganglion of vagus nerve
7701:Metabotropic glutamate
4953:"Dopamine Receptors: D
4643:10.1006/geno.1993.1489
4088:10.1124/mol.108.051805
4076:Molecular Pharmacology
3262:10.1074/jbc.M003245200
2799:Molecular Neurobiology
2087:. Heteromers between D
2040:
1881:prevents p50, part of
1622:long-term potentiation
1356:Central nervous system
1142:family along with the
372:pancreatic ductal cell
5730:Lysophosphatidic acid
5034:Cell surface receptor
3095:AJP: Renal Physiology
2456:10.1124/pr.110.002642
2191:in situ hybridization
2073:intracellular calcium
2034:
1883:NF-κB protein complex
1862:. The expression of D
1641:hippocampal formation
1630:medial perforant path
1593:redundantly activate
1575:-Muscarinic receptors
1528:Clinical significance
1408:. Dopamine receptor D
1055:Chr 4: 9.78 – 9.78 Mb
609:brush border membrane
7655:Vomeronasal receptor
6625:Vomeronasal receptor
4798:10.1212/wnl.58.1.124
3604:Neuroscience Letters
3561:Neuroscience Letters
3420:Neuroscience Letters
3385:Psychiatric Genetics
2171:immunohistochemistry
2149:Experimental methods
1676:Dinucleotide repeats
1599:basolateral amygdala
1370:dopamine receptor D1
1320:Chromosomal location
1297:receptor has a long
1291:amino acid sequences
1191:family of G proteins
1134:. It belongs to the
745:long-term depression
670:associative learning
458:vasculature of organ
245:Chromosome 5 (mouse)
143:Chromosome 4 (human)
7548:Parathyroid hormone
5508:signaling molecules
4980:DRD5+protein,+human
4967:on 31 December 2014
4753:2000Natur.403..274L
4613:10.1021/bi00017a025
4583:10.1093/hmg/4.4.507
4498:1991PNAS...88.9175G
4445:1991PNAS...88.7491T
4396:1991Natur.350..614S
4168:2000Natur.403..274L
3740:2013PLoSO...875975H
3305:2014PNAS..111.8245S
2559:1991PNAS...88.9175G
2405:1991Natur.350..614S
2133:Dopamine receptor D
1739:Parkinson's disease
1731:subthalamic nucleus
1717:Parkinson's disease
1533:Learning and memory
1445:superior colliculus
1278:receptor is highly
1114:Dopamine receptor D
750:signal transduction
645:response to cocaine
434:trigeminal ganglion
284:5 B3|5 20.4 cM
7937:Dopamine receptors
7697:Glutamate receptor
7082:Protease-activated
4995:, which is in the
4267:10.1002/gene.10069
3984:Psychopharmacology
2846:Movement Disorders
2137:has been shown to
2041:
1423:. Within a cell, D
1201:subtypes activate
1185:via activation of
900:ENSMUSG00000039358
638:Biological process
582:Cellular component
541:Molecular function
438:hippocampus proper
7919:
7918:
7915:
7914:
7911:
7910:
7803:
7802:
7799:
7798:
7590:
7589:
7586:
7585:
7138:
7137:
7134:
7133:
7130:
7129:
6471:
6470:
5858:
5857:
5501:
5500:
4884:10.1002/cne.10525
4747:(6767): 274–280.
4607:(17): 5960–5970.
4492:(20): 9175–9179.
4439:(17): 7491–7495.
4390:(6319): 614–619.
4133:10.1021/bi0259610
4049:10.1021/jm051237e
3947:10.1111/bph.12988
3361:10.1002/ajmg.1301
3349:Am. J. Med. Genet
2858:10.1002/mds.25493
2250:Dopamine receptor
2163:Antibody staining
1906:T helper 17 cells
1838:and excretion of
1711:learning problems
1705:. Deficiency in D
1695:was found in the
1270:Primary structure
1250:prefrontal cortex
1111:
1110:
1107:
1106:
1080:
1079:
1045:
1044:
1024:
1023:
998:
997:
977:
976:
951:
950:
932:
931:
906:
905:
887:
886:
861:
860:
842:
841:
790:
789:
619:non-motile cilium
525:
524:
521:
520:
490:
489:
477:
476:
415:
414:
384:prefrontal cortex
313:
312:
212:
211:
16:(Redirected from
7944:
7827:
7826:
7809:
7808:
7620:
7619:
7596:
7595:
7162:
7161:
7144:
7143:
6480:
6479:
5867:
5866:
5765:Lysophospholipid
5512:
5511:
5073:
5072:
5068:Neurotransmitter
5064:
5063:
5046:
5045:
5027:
5020:
5013:
5004:
5003:
4976:
4974:
4972:
4940:
4930:
4905:
4895:
4862:
4852:
4842:
4817:
4780:
4761:10.1038/35002014
4735:
4697:
4679:
4670:(6): 2459–2467.
4654:
4624:
4594:
4564:
4554:
4545:(33): 22427–35.
4529:
4519:
4509:
4476:
4466:
4456:
4423:
4404:10.1038/350614a0
4377:
4347:
4318:
4280:
4279:
4269:
4245:
4239:
4238:
4202:
4196:
4195:
4176:10.1038/35002014
4162:(6767): 274–80.
4151:
4145:
4144:
4127:(38): 11344–50.
4116:
4110:
4109:
4099:
4067:
4061:
4060:
4043:(6): 2110–2116.
4027:
4018:
4017:
4007:
3975:
3969:
3968:
3958:
3914:
3908:
3907:
3897:
3873:
3867:
3866:
3856:
3832:
3826:
3825:
3815:
3805:
3796:(24): 10801–10.
3781:
3772:
3771:
3761:
3751:
3719:
3713:
3712:
3702:
3678:
3672:
3671:
3642:
3636:
3635:
3599:
3593:
3592:
3556:
3550:
3549:
3539:
3529:
3505:
3496:
3495:
3458:
3452:
3451:
3415:
3409:
3408:
3379:
3373:
3372:
3343:
3337:
3336:
3326:
3316:
3284:
3275:
3274:
3264:
3255:(31): 24089–95.
3240:
3234:
3233:
3223:
3191:
3180:
3179:
3169:
3159:
3135:
3129:
3128:
3118:
3086:
3071:
3070:
3060:
3036:
3027:
3026:
3016:
2988:
2982:
2981:
2945:
2939:
2938:
2928:
2918:
2894:
2888:
2887:
2869:
2837:
2831:
2830:
2794:
2779:
2778:
2749:
2743:
2742:
2732:
2700:
2689:
2688:
2678:
2669:(45): 27925–31.
2654:
2645:
2644:
2634:
2602:
2591:
2590:
2580:
2570:
2538:
2527:
2526:
2493:(4): 1049–1053.
2482:
2476:
2475:
2439:
2433:
2432:
2413:10.1038/350614a0
2387:
2376:
2375:
2343:
2337:
2336:
2325:
2319:
2318:
2307:
2301:
2291:
2280:
2270:
2007:Inverse agonists
1828:sympathetic tone
1790:. Mice lacking D
1611:action potential
1577:cooperate with D
1441:olfactory region
1289:receptor. Their
1248:in rat and mice
1246:protein kinase B
1203:adenylyl cyclase
1183:adenylyl cyclase
1148:receptor subtype
1119:, also known as
1093:
1092:
1064:
1057:
1040:
1028:
1027:
1019:
1007:
1006:
1003:RefSeq (protein)
993:
981:
980:
972:
960:
959:
936:
935:
917:
916:
891:
890:
872:
871:
846:
845:
827:
826:
796:
795:
614:ciliary membrane
563:dopamine binding
531:
530:
517:
508:
501:
500:
486:
426:
424:Top expressed in
419:
418:
364:
362:Top expressed in
357:
356:
336:
335:
319:
318:
309:
296:
285:
270:
263:
257:
246:
234:
218:
217:
208:
195:
184:
169:
162:
156:
145:
131:
115:
114:
109:
107:DRD5 - orthologs
60:
53:
32:
31:
21:
7952:
7951:
7947:
7946:
7945:
7943:
7942:
7941:
7922:
7921:
7920:
7907:
7891:
7821:
7795:
7682:
7660:
7614:
7582:
7464:
7341:
7156:
7126:
7013:
6630:
6467:
6073:Cholecystokinin
5977:
5854:
5683:Free fatty acid
5623:
5507:
5506:Metabolites and
5497:
5337:
5242:
5139:
5058:
5040:
5031:
4970:
4968:
4956:
4951:
4948:
4943:
4872:J. Comp. Neurol
4833:(19): 8476–86.
4571:Hum. Mol. Genet
4288:
4286:Further reading
4283:
4246:
4242:
4203:
4199:
4152:
4148:
4117:
4113:
4068:
4064:
4034:
4028:
4021:
3976:
3972:
3930:
3926:
3922:
3915:
3911:
3874:
3870:
3847:(6): 2792–800.
3833:
3829:
3782:
3775:
3720:
3716:
3679:
3675:
3643:
3639:
3600:
3596:
3557:
3553:
3520:(37): 14840–9.
3506:
3499:
3459:
3455:
3416:
3412:
3380:
3376:
3344:
3340:
3299:(22): 8245–50.
3285:
3278:
3241:
3237:
3192:
3183:
3150:(24): 8506–12.
3136:
3132:
3087:
3074:
3037:
3030:
2989:
2985:
2946:
2942:
2909:(12): 7821–36.
2895:
2891:
2838:
2834:
2795:
2782:
2750:
2746:
2701:
2692:
2655:
2648:
2603:
2594:
2539:
2530:
2483:
2479:
2440:
2436:
2399:(6319): 614–9.
2388:
2379:
2344:
2340:
2327:
2326:
2322:
2309:
2308:
2304:
2292:
2283:
2271:
2262:
2258:
2246:
2231:
2227:
2215:
2200:
2196:
2168:
2160:
2156:
2151:
2136:
2129:
2121:
2117:
2113:
2102:
2094:
2090:
2081:phospholipase C
2068:
2058:
2053:
2038:
2027:
2021:
2009:
1977:
1970:
1966:
1959:
1955:
1951:
1947:
1943:
1939:
1935:
1930:
1903:
1880:
1865:
1853:
1848:
1833:
1813:
1808:
1796:methamphetamine
1793:
1784:psychostimulant
1781:
1776:
1756:
1745:receptors with
1744:
1724:
1719:
1708:
1694:
1673:
1662:
1654:
1649:
1619:
1595:phospholipase C
1580:
1574:
1564:
1554:
1540:
1535:
1530:
1515:
1491:
1486:
1474:dendritic cells
1454:
1426:
1411:
1398:basal forebrain
1363:
1358:
1353:
1339:
1327:
1322:
1314:
1308:
1296:
1287:
1277:
1272:
1261:
1242:phosphorylation
1235:
1232:Activation of D
1228:
1224:
1220:
1208:
1200:
1196:
1190:
1172:
1167:
1161:
1156:
1147:
1139:
1117:
1102:View/Edit Mouse
1097:View/Edit Human
1060:
1053:
1050:Location (UCSC)
1036:
1015:
989:
968:
881:ENSG00000169676
774:
715:mating behavior
633:
599:plasma membrane
577:
513:
482:
473:
468:
464:
460:
456:
452:
448:
444:
440:
436:
422:
411:
406:
402:
398:
396:Brodmann area 9
394:
390:
386:
382:
380:mucosa of ileum
378:
374:
360:
304:
291:
283:
273:
272:
271:
264:
244:
221:Gene location (
203:
190:
182:
172:
171:
170:
163:
141:
118:Gene location (
69:
56:
49:
28:
23:
22:
15:
12:
11:
5:
7950:
7940:
7939:
7934:
7917:
7916:
7913:
7912:
7909:
7908:
7906:
7905:
7899:
7897:
7893:
7892:
7890:
7889:
7883:
7878:
7873:
7868:
7863:
7858:
7853:
7848:
7843:
7833:
7831:
7823:
7822:
7805:
7804:
7801:
7800:
7797:
7796:
7794:
7793:
7787:
7782:
7777:
7768:
7762:
7757:
7748:
7743:
7737:
7732:
7727:
7722:
7717:
7712:
7707:
7694:
7688:
7680:
7676:
7670:
7668:
7662:
7661:
7659:
7658:
7652:
7651:
7650:
7645:
7640:
7629:
7627:
7616:
7615:
7592:
7591:
7588:
7587:
7584:
7583:
7581:
7580:
7574:
7565:
7560:
7554:
7545:
7540:
7535:
7530:
7525:
7519:
7514:
7509:
7500:
7494:
7485:
7480:
7474:
7472:
7466:
7465:
7463:
7462:
7456:
7451:
7446:
7441:
7436:
7431:
7426:
7421:
7416:
7411:
7406:
7401:
7396:
7391:
7386:
7381:
7376:
7371:
7366:
7361:
7351:
7349:
7343:
7342:
7340:
7339:
7338:
7337:
7332:
7331:
7330:
7325:
7320:
7305:
7304:
7303:
7298:
7293:
7288:
7283:
7278:
7273:
7263:
7262:
7261:
7256:
7255:
7254:
7249:
7244:
7229:
7228:
7227:
7226:
7225:
7220:
7215:
7200:
7199:
7198:
7197:
7196:
7191:
7186:
7170:
7168:
7158:
7157:
7140:
7139:
7136:
7135:
7132:
7131:
7128:
7127:
7125:
7124:
7118:
7113:
7104:
7098:
7093:
7088:
7079:
7073:
7068:
7063:
7058:
7053:
7048:
7043:
7034:
7029:
7027:Adrenomedullin
7023:
7021:
7015:
7014:
7012:
7011:
7005:
7000:
6995:
6990:
6985:
6980:
6975:
6970:
6965:
6960:
6955:
6950:
6945:
6940:
6935:
6930:
6925:
6920:
6915:
6910:
6905:
6900:
6895:
6890:
6885:
6880:
6875:
6870:
6865:
6860:
6855:
6850:
6845:
6840:
6835:
6830:
6825:
6820:
6815:
6810:
6805:
6800:
6795:
6790:
6785:
6780:
6775:
6770:
6765:
6760:
6755:
6750:
6745:
6740:
6735:
6730:
6725:
6720:
6715:
6710:
6705:
6700:
6695:
6690:
6685:
6680:
6675:
6670:
6665:
6660:
6655:
6650:
6640:
6638:
6632:
6631:
6629:
6628:
6622:
6621:
6620:
6615:
6610:
6605:
6600:
6595:
6590:
6585:
6580:
6575:
6570:
6565:
6560:
6555:
6550:
6545:
6540:
6535:
6530:
6525:
6520:
6515:
6510:
6505:
6500:
6489:
6487:
6477:
6473:
6472:
6469:
6468:
6466:
6465:
6459:
6454:
6445:
6440:
6435:
6430:
6424:
6419:
6410:
6404:
6399:
6394:
6389:
6380:
6374:
6369:
6364:
6355:
6350:
6344:
6335:
6330:
6324:
6315:
6301:
6296:
6291:
6282:
6277:
6271:
6262:
6256:
6251:
6246:
6241:
6232:
6226:
6221:
6216:
6211:
6206:
6201:
6196:
6191:
6186:
6177:
6172:
6167:
6162:
6156:
6147:
6141:
6136:
6127:
6122:
6116:
6111:
6105:Formyl peptide
6102:
6101:
6100:
6095:
6085:
6079:
6070:
6065:
6064:
6063:
6057:
6048:
6042:
6037:
6027:
6022:
6016:
6007:
6001:
5995:
5985:
5983:
5979:
5978:
5976:
5975:
5969:
5960:
5954:
5945:
5936:
5930:
5925:
5920:
5911:
5906:
5900:
5891:
5885:
5875:
5873:
5864:
5860:
5859:
5856:
5855:
5853:
5852:
5847:
5841:
5836:
5831:
5826:
5817:
5812:
5807:
5801:
5796:
5791:
5786:
5781:
5776:
5771:
5762:
5756:
5751:
5746:
5741:
5736:
5727:
5726:
5725:
5720:
5715:
5705:
5699:
5694:
5689:
5680:
5675:
5670:
5664:
5659:
5646:
5637:
5631:
5629:
5625:
5624:
5622:
5621:
5616:
5611:
5610:
5609:
5600:
5595:
5590:
5577:
5563:
5558:
5553:
5552:
5551:
5546:
5536:
5530:
5520:
5518:
5509:
5503:
5502:
5499:
5498:
5496:
5495:
5489:
5484:
5479:
5474:
5469:
5460:
5454:
5449:
5440:
5439:
5438:
5433:
5428:
5423:
5413:
5408:
5407:
5406:
5401:
5396:
5391:
5386:
5376:
5370:
5365:
5360:
5355:
5345:
5343:
5339:
5338:
5336:
5335:
5329:
5324:
5319:
5310:
5304:
5299:
5290:
5284:
5279:
5274:
5269:
5252:
5250:
5244:
5243:
5241:
5240:
5234:
5229:
5224:
5219:
5214:
5209:
5204:
5199:
5194:
5189:
5184:
5175:
5169:
5164:
5159:
5149:
5147:
5141:
5140:
5138:
5137:
5132:
5127:
5122:
5116:
5111:
5102:
5096:
5091:
5081:
5079:
5070:
5060:
5059:
5042:
5041:
5030:
5029:
5022:
5015:
5007:
4988:
4987:
4977:
4954:
4947:
4946:External links
4944:
4942:
4941:
4921:(3): 604–610.
4906:
4878:(2): 176–183.
4863:
4818:
4781:
4736:
4710:(3): 231–238.
4698:
4655:
4637:(2): 423–425.
4625:
4595:
4577:(4): 507–514.
4565:
4530:
4477:
4424:
4378:
4360:(3): 510–516.
4348:
4330:(4): 968–973.
4319:
4301:(1): 189–225.
4289:
4287:
4284:
4282:
4281:
4240:
4197:
4146:
4111:
4062:
4032:
4019:
3970:
3941:(4): 1124–35.
3928:
3924:
3920:
3909:
3888:(7): 3062–70.
3868:
3827:
3773:
3734:(10): e75975.
3714:
3693:(1): 1609–18.
3673:
3637:
3594:
3551:
3497:
3453:
3410:
3374:
3338:
3276:
3235:
3181:
3130:
3101:(6): F588–96.
3072:
3028:
2983:
2950:Brain Research
2940:
2889:
2852:(10): 1351–9.
2832:
2780:
2744:
2690:
2646:
2592:
2553:(20): 9175–9.
2528:
2477:
2450:(1): 182–217.
2444:Pharmacol. Rev
2434:
2377:
2358:(3): 777–778.
2338:
2320:
2302:
2281:
2259:
2257:
2254:
2253:
2252:
2245:
2242:
2229:
2225:
2213:
2198:
2194:
2166:
2158:
2154:
2150:
2147:
2134:
2127:
2119:
2115:
2111:
2108:glutamic acids
2100:
2092:
2088:
2066:
2056:
2052:
2049:
2048:
2047:
2036:
2029:
2028:
2025:
2020:
2017:
2016:
2015:
2008:
2005:
2004:
2003:
1998:
1993:
1988:
1983:
1976:
1973:
1968:
1964:
1957:
1953:
1949:
1945:
1941:
1937:
1933:
1929:
1926:
1918:interleukin 23
1914:interleukin 12
1901:
1878:
1863:
1851:
1847:
1844:
1831:
1824:blood pressure
1816:blood pressure
1811:
1807:
1804:
1791:
1779:
1775:
1772:
1755:
1752:
1742:
1722:
1718:
1715:
1706:
1700:pyramidal cell
1692:
1672:
1669:
1660:
1653:
1650:
1648:
1645:
1617:
1581:receptors and
1578:
1572:
1562:
1552:
1538:
1534:
1531:
1529:
1526:
1513:
1489:
1485:
1482:
1478:T helper cells
1452:
1424:
1409:
1378:frontal cortex
1361:
1357:
1354:
1352:
1349:
1337:
1325:
1321:
1318:
1312:
1306:
1294:
1285:
1275:
1271:
1268:
1259:
1233:
1226:
1222:
1218:
1211:dose-dependent
1206:
1198:
1194:
1188:
1170:
1169:subtype. The D
1165:
1159:
1155:
1152:
1145:
1140:-like receptor
1137:
1115:
1109:
1108:
1105:
1104:
1099:
1089:
1088:
1082:
1081:
1078:
1077:
1075:
1073:
1066:
1065:
1058:
1051:
1047:
1046:
1043:
1042:
1032:
1031:
1025:
1022:
1021:
1011:
1010:
1004:
1000:
999:
996:
995:
985:
984:
978:
975:
974:
964:
963:
957:
953:
952:
949:
948:
940:
939:
933:
930:
929:
921:
920:
914:
908:
907:
904:
903:
895:
894:
888:
885:
884:
876:
875:
869:
863:
862:
859:
858:
850:
849:
843:
840:
839:
831:
830:
824:
818:
817:
812:
807:
803:
802:
792:
791:
788:
787:
776:
775:
773:
772:
767:
762:
757:
752:
747:
742:
737:
732:
727:
722:
717:
712:
707:
702:
697:
692:
687:
682:
677:
672:
667:
662:
657:
652:
647:
641:
639:
635:
634:
632:
631:
626:
621:
616:
611:
606:
601:
596:
591:
585:
583:
579:
578:
576:
575:
570:
565:
560:
555:
550:
544:
542:
538:
537:
527:
526:
523:
522:
519:
518:
510:
509:
498:
492:
491:
488:
487:
479:
478:
475:
474:
472:
471:
467:
463:
459:
455:
451:
447:
443:
442:spinal ganglia
439:
435:
431:
428:
427:
416:
413:
412:
410:
409:
405:
401:
397:
393:
392:deltoid muscle
389:
385:
381:
377:
373:
369:
366:
365:
353:
352:
344:
333:
327:
326:
323:RNA expression
315:
314:
311:
310:
302:
298:
297:
289:
286:
281:
275:
274:
265:
258:
252:
248:
247:
242:
236:
235:
227:
226:
214:
213:
210:
209:
201:
197:
196:
188:
185:
180:
174:
173:
164:
157:
151:
147:
146:
139:
133:
132:
124:
123:
111:
110:
67:
63:
62:
54:
46:
45:
41:
40:
37:
36:
26:
9:
6:
4:
3:
2:
7949:
7938:
7935:
7933:
7930:
7929:
7927:
7904:
7901:
7900:
7898:
7894:
7887:
7884:
7882:
7879:
7877:
7874:
7872:
7869:
7867:
7864:
7862:
7859:
7857:
7854:
7852:
7849:
7847:
7844:
7842:
7838:
7835:
7834:
7832:
7828:
7824:
7820:
7816:
7810:
7806:
7791:
7788:
7786:
7783:
7781:
7778:
7776:
7772:
7769:
7766:
7763:
7761:
7758:
7756:
7752:
7749:
7747:
7744:
7741:
7738:
7736:
7733:
7731:
7728:
7726:
7723:
7721:
7718:
7716:
7713:
7711:
7708:
7706:
7702:
7698:
7695:
7692:
7689:
7687:
7683:
7677:
7675:
7672:
7671:
7669:
7667:
7663:
7656:
7653:
7649:
7646:
7644:
7641:
7639:
7636:
7635:
7634:
7631:
7630:
7628:
7625:
7621:
7617:
7613:
7609:
7606:
7602:
7597:
7593:
7578:
7575:
7573:
7569:
7566:
7564:
7561:
7558:
7555:
7553:
7549:
7546:
7544:
7541:
7539:
7536:
7534:
7531:
7529:
7526:
7523:
7520:
7518:
7515:
7513:
7510:
7508:
7504:
7501:
7498:
7495:
7493:
7489:
7486:
7484:
7481:
7479:
7476:
7475:
7473:
7471:
7467:
7460:
7457:
7455:
7452:
7450:
7447:
7445:
7442:
7440:
7437:
7435:
7432:
7430:
7427:
7425:
7422:
7420:
7417:
7415:
7412:
7410:
7407:
7405:
7402:
7400:
7397:
7395:
7392:
7390:
7387:
7385:
7382:
7380:
7377:
7375:
7372:
7370:
7367:
7365:
7362:
7360:
7356:
7353:
7352:
7350:
7348:
7344:
7336:
7333:
7329:
7326:
7324:
7321:
7319:
7316:
7315:
7314:
7311:
7310:
7309:
7306:
7302:
7299:
7297:
7294:
7292:
7289:
7287:
7284:
7282:
7279:
7277:
7274:
7272:
7269:
7268:
7267:
7264:
7260:
7257:
7253:
7250:
7248:
7245:
7243:
7240:
7239:
7238:
7235:
7234:
7233:
7230:
7224:
7221:
7219:
7216:
7214:
7211:
7210:
7209:
7206:
7205:
7204:
7201:
7195:
7192:
7190:
7187:
7185:
7182:
7181:
7180:
7177:
7176:
7175:
7172:
7171:
7169:
7167:
7163:
7159:
7154:
7150:
7145:
7141:
7122:
7119:
7117:
7114:
7112:
7108:
7105:
7102:
7099:
7097:
7094:
7092:
7089:
7087:
7083:
7080:
7077:
7074:
7072:
7069:
7067:
7064:
7062:
7059:
7057:
7054:
7052:
7049:
7047:
7044:
7042:
7038:
7035:
7033:
7030:
7028:
7025:
7024:
7022:
7020:
7016:
7009:
7006:
7004:
7001:
6999:
6996:
6994:
6991:
6989:
6986:
6984:
6981:
6979:
6976:
6974:
6971:
6969:
6966:
6964:
6961:
6959:
6956:
6954:
6951:
6949:
6946:
6944:
6941:
6939:
6936:
6934:
6931:
6929:
6926:
6924:
6921:
6919:
6916:
6914:
6911:
6909:
6906:
6904:
6901:
6899:
6896:
6894:
6891:
6889:
6886:
6884:
6881:
6879:
6876:
6874:
6871:
6869:
6866:
6864:
6861:
6859:
6856:
6854:
6851:
6849:
6846:
6844:
6841:
6839:
6836:
6834:
6831:
6829:
6826:
6824:
6821:
6819:
6816:
6814:
6811:
6809:
6806:
6804:
6801:
6799:
6796:
6794:
6791:
6789:
6786:
6784:
6781:
6779:
6776:
6774:
6771:
6769:
6766:
6764:
6761:
6759:
6756:
6754:
6751:
6749:
6746:
6744:
6741:
6739:
6736:
6734:
6731:
6729:
6726:
6724:
6721:
6719:
6716:
6714:
6711:
6709:
6706:
6704:
6701:
6699:
6696:
6694:
6691:
6689:
6686:
6684:
6681:
6679:
6676:
6674:
6671:
6669:
6666:
6664:
6661:
6659:
6656:
6654:
6651:
6649:
6645:
6642:
6641:
6639:
6637:
6633:
6626:
6623:
6619:
6616:
6614:
6611:
6609:
6606:
6604:
6601:
6599:
6596:
6594:
6591:
6589:
6586:
6584:
6581:
6579:
6576:
6574:
6571:
6569:
6566:
6564:
6561:
6559:
6556:
6554:
6551:
6549:
6546:
6544:
6541:
6539:
6536:
6534:
6531:
6529:
6526:
6524:
6521:
6519:
6516:
6514:
6511:
6509:
6506:
6504:
6501:
6499:
6496:
6495:
6494:
6491:
6490:
6488:
6485:
6481:
6478:
6476:Miscellaneous
6474:
6463:
6460:
6458:
6455:
6453:
6449:
6446:
6444:
6441:
6439:
6436:
6434:
6431:
6428:
6425:
6423:
6420:
6418:
6414:
6411:
6408:
6405:
6403:
6400:
6398:
6395:
6393:
6390:
6388:
6384:
6381:
6378:
6375:
6373:
6370:
6368:
6365:
6363:
6359:
6356:
6354:
6351:
6348:
6345:
6343:
6339:
6336:
6334:
6331:
6328:
6325:
6323:
6319:
6316:
6313:
6309:
6305:
6302:
6300:
6297:
6295:
6292:
6290:
6286:
6283:
6281:
6278:
6275:
6272:
6270:
6266:
6263:
6260:
6257:
6255:
6252:
6250:
6247:
6245:
6242:
6240:
6236:
6233:
6230:
6227:
6225:
6222:
6220:
6217:
6215:
6212:
6210:
6207:
6205:
6202:
6200:
6197:
6195:
6192:
6190:
6187:
6185:
6181:
6178:
6176:
6173:
6171:
6168:
6166:
6163:
6160:
6157:
6155:
6151:
6148:
6145:
6142:
6140:
6137:
6135:
6131:
6128:
6126:
6123:
6120:
6117:
6115:
6112:
6110:
6106:
6103:
6099:
6096:
6094:
6091:
6090:
6089:
6086:
6083:
6080:
6078:
6074:
6071:
6069:
6066:
6061:
6058:
6056:
6052:
6049:
6046:
6043:
6041:
6038:
6036:
6033:
6032:
6031:
6028:
6026:
6023:
6020:
6017:
6015:
6011:
6008:
6005:
6002:
6000:
5996:
5994:
5990:
5989:Anaphylatoxin
5987:
5986:
5984:
5980:
5973:
5970:
5968:
5964:
5961:
5958:
5955:
5953:
5949:
5946:
5944:
5940:
5937:
5934:
5931:
5929:
5926:
5924:
5921:
5919:
5915:
5912:
5910:
5907:
5904:
5901:
5899:
5895:
5892:
5889:
5886:
5884:
5880:
5877:
5876:
5874:
5872:
5868:
5865:
5861:
5851:
5848:
5845:
5842:
5840:
5837:
5835:
5832:
5830:
5827:
5825:
5821:
5818:
5816:
5813:
5811:
5808:
5805:
5802:
5800:
5797:
5795:
5792:
5790:
5787:
5785:
5782:
5780:
5777:
5775:
5772:
5770:
5766:
5763:
5760:
5757:
5755:
5752:
5750:
5747:
5745:
5742:
5740:
5737:
5735:
5731:
5728:
5724:
5721:
5719:
5716:
5714:
5711:
5710:
5709:
5706:
5703:
5700:
5698:
5695:
5693:
5690:
5688:
5684:
5681:
5679:
5676:
5674:
5671:
5668:
5665:
5663:
5660:
5658:
5654:
5650:
5647:
5645:
5641:
5638:
5636:
5633:
5632:
5630:
5626:
5620:
5617:
5615:
5612:
5608:
5604:
5601:
5599:
5596:
5594:
5591:
5589:
5585:
5581:
5578:
5576:
5572:
5569:
5568:
5567:
5566:Prostaglandin
5564:
5562:
5559:
5557:
5554:
5550:
5547:
5545:
5542:
5541:
5540:
5537:
5534:
5531:
5529:
5525:
5522:
5521:
5519:
5517:
5513:
5510:
5504:
5493:
5490:
5488:
5485:
5483:
5480:
5478:
5475:
5473:
5470:
5468:
5464:
5461:
5458:
5455:
5453:
5450:
5448:
5444:
5441:
5437:
5434:
5432:
5429:
5427:
5424:
5422:
5419:
5418:
5417:
5414:
5412:
5409:
5405:
5402:
5400:
5397:
5395:
5392:
5390:
5387:
5385:
5382:
5381:
5380:
5377:
5374:
5371:
5369:
5366:
5364:
5361:
5359:
5356:
5354:
5350:
5349:Acetylcholine
5347:
5346:
5344:
5340:
5333:
5330:
5328:
5325:
5323:
5320:
5318:
5314:
5311:
5308:
5305:
5303:
5300:
5298:
5294:
5291:
5288:
5285:
5283:
5280:
5278:
5275:
5273:
5270:
5268:
5264:
5261:
5259:
5254:
5253:
5251:
5249:
5245:
5238:
5235:
5233:
5230:
5228:
5225:
5223:
5220:
5218:
5215:
5213:
5210:
5208:
5205:
5203:
5200:
5198:
5195:
5193:
5190:
5188:
5185:
5183:
5179:
5176:
5173:
5170:
5168:
5165:
5163:
5160:
5158:
5154:
5151:
5150:
5148:
5146:
5142:
5136:
5133:
5131:
5128:
5126:
5123:
5120:
5117:
5115:
5112:
5110:
5106:
5103:
5100:
5097:
5095:
5092:
5090:
5086:
5083:
5082:
5080:
5078:
5074:
5071:
5069:
5065:
5061:
5056:
5052:
5047:
5043:
5039:
5035:
5028:
5023:
5021:
5016:
5014:
5009:
5008:
5005:
5001:
5000:
4998:
4997:public domain
4994:
4985:
4981:
4978:
4966:
4962:
4958:
4950:
4949:
4938:
4934:
4929:
4924:
4920:
4916:
4912:
4907:
4903:
4899:
4894:
4889:
4885:
4881:
4877:
4873:
4869:
4864:
4860:
4856:
4851:
4846:
4841:
4836:
4832:
4828:
4824:
4819:
4815:
4811:
4807:
4803:
4799:
4795:
4791:
4787:
4782:
4778:
4774:
4770:
4766:
4762:
4758:
4754:
4750:
4746:
4742:
4737:
4733:
4729:
4725:
4721:
4717:
4716:10.1038/10290
4713:
4709:
4705:
4699:
4695:
4691:
4687:
4683:
4678:
4673:
4669:
4665:
4661:
4656:
4652:
4648:
4644:
4640:
4636:
4632:
4626:
4622:
4618:
4614:
4610:
4606:
4602:
4596:
4592:
4588:
4584:
4580:
4576:
4572:
4566:
4562:
4558:
4553:
4548:
4544:
4540:
4539:J. Biol. Chem
4536:
4531:
4527:
4523:
4518:
4513:
4508:
4503:
4499:
4495:
4491:
4487:
4483:
4478:
4474:
4470:
4465:
4460:
4455:
4450:
4446:
4442:
4438:
4434:
4430:
4425:
4421:
4417:
4413:
4409:
4405:
4401:
4397:
4393:
4389:
4385:
4379:
4375:
4371:
4367:
4363:
4359:
4355:
4349:
4345:
4341:
4337:
4333:
4329:
4325:
4320:
4316:
4312:
4308:
4304:
4300:
4296:
4291:
4290:
4277:
4273:
4268:
4263:
4259:
4255:
4251:
4244:
4236:
4232:
4228:
4224:
4220:
4216:
4213:(5): 347–54.
4212:
4208:
4201:
4193:
4189:
4185:
4181:
4177:
4173:
4169:
4165:
4161:
4157:
4150:
4142:
4138:
4134:
4130:
4126:
4122:
4115:
4107:
4103:
4098:
4093:
4089:
4085:
4082:(4): 843–54.
4081:
4077:
4073:
4066:
4058:
4054:
4050:
4046:
4042:
4038:
4026:
4024:
4015:
4011:
4006:
4001:
3997:
3993:
3990:(5): 917–30.
3989:
3985:
3981:
3974:
3966:
3962:
3957:
3952:
3948:
3944:
3940:
3936:
3932:
3913:
3905:
3901:
3896:
3891:
3887:
3883:
3879:
3872:
3864:
3860:
3855:
3850:
3846:
3842:
3838:
3831:
3823:
3819:
3814:
3809:
3804:
3799:
3795:
3791:
3787:
3780:
3778:
3769:
3765:
3760:
3755:
3750:
3745:
3741:
3737:
3733:
3729:
3725:
3718:
3710:
3706:
3701:
3696:
3692:
3688:
3684:
3677:
3669:
3665:
3661:
3657:
3653:
3649:
3641:
3633:
3629:
3625:
3621:
3617:
3613:
3609:
3605:
3598:
3590:
3586:
3582:
3578:
3574:
3570:
3566:
3562:
3555:
3547:
3543:
3538:
3533:
3528:
3523:
3519:
3515:
3511:
3504:
3502:
3493:
3489:
3485:
3481:
3477:
3473:
3469:
3465:
3457:
3449:
3445:
3441:
3437:
3433:
3429:
3425:
3421:
3414:
3406:
3402:
3398:
3394:
3390:
3386:
3378:
3370:
3366:
3362:
3358:
3355:(3): 259–65.
3354:
3350:
3342:
3334:
3330:
3325:
3320:
3315:
3310:
3306:
3302:
3298:
3294:
3290:
3283:
3281:
3272:
3268:
3263:
3258:
3254:
3250:
3246:
3239:
3231:
3227:
3222:
3217:
3213:
3209:
3206:(5): 1570–8.
3205:
3201:
3197:
3190:
3188:
3186:
3177:
3173:
3168:
3163:
3158:
3153:
3149:
3145:
3141:
3134:
3126:
3122:
3117:
3112:
3108:
3104:
3100:
3096:
3092:
3085:
3083:
3081:
3079:
3077:
3068:
3064:
3059:
3054:
3051:(2): 187–97.
3050:
3046:
3042:
3035:
3033:
3024:
3020:
3015:
3010:
3006:
3002:
2999:(2): 184–94.
2998:
2994:
2987:
2979:
2975:
2971:
2967:
2963:
2959:
2955:
2951:
2944:
2936:
2932:
2927:
2922:
2917:
2912:
2908:
2904:
2900:
2893:
2885:
2881:
2877:
2873:
2868:
2863:
2859:
2855:
2851:
2847:
2843:
2836:
2828:
2824:
2820:
2816:
2812:
2808:
2805:(3): 605–20.
2804:
2800:
2793:
2791:
2789:
2787:
2785:
2776:
2772:
2768:
2764:
2760:
2756:
2748:
2740:
2736:
2731:
2726:
2722:
2718:
2714:
2710:
2706:
2699:
2697:
2695:
2686:
2682:
2677:
2672:
2668:
2664:
2663:J. Biol. Chem
2660:
2653:
2651:
2642:
2638:
2633:
2628:
2624:
2620:
2617:(2): 477–83.
2616:
2612:
2608:
2601:
2599:
2597:
2588:
2584:
2579:
2574:
2569:
2564:
2560:
2556:
2552:
2548:
2544:
2537:
2535:
2533:
2524:
2520:
2516:
2512:
2508:
2504:
2500:
2496:
2492:
2488:
2481:
2473:
2469:
2465:
2461:
2457:
2453:
2449:
2445:
2438:
2430:
2426:
2422:
2418:
2414:
2410:
2406:
2402:
2398:
2394:
2386:
2384:
2382:
2373:
2369:
2365:
2361:
2357:
2353:
2349:
2342:
2334:
2330:
2324:
2316:
2312:
2306:
2299:
2295:
2290:
2288:
2286:
2278:
2274:
2269:
2267:
2265:
2260:
2251:
2248:
2247:
2241:
2239:
2235:
2223:
2219:
2211:
2207:
2202:
2192:
2188:
2184:
2180:
2176:
2172:
2164:
2146:
2144:
2140:
2131:
2125:
2109:
2106:
2098:
2086:
2082:
2078:
2074:
2070:
2062:
2046:
2043:
2042:
2033:
2023:
2022:
2014:
2011:
2010:
2002:
1999:
1997:
1994:
1992:
1989:
1987:
1984:
1982:
1981:Dihydrexidine
1979:
1978:
1972:
1961:
1925:
1923:
1919:
1915:
1911:
1907:
1898:
1896:
1892:
1888:
1884:
1876:
1875:proliferation
1872:
1871:interleukin 2
1869:
1861:
1857:
1843:
1841:
1837:
1829:
1825:
1822:and elevated
1821:
1817:
1803:
1801:
1797:
1789:
1785:
1771:
1769:
1765:
1761:
1760:schizophrenia
1754:Schizophrenia
1751:
1748:
1740:
1737:rat model of
1736:
1732:
1728:
1714:
1712:
1704:
1701:
1698:
1690:
1685:
1681:
1677:
1668:
1666:
1658:
1657:Polymorphisms
1644:
1642:
1639:
1635:
1634:dentate gyrus
1631:
1627:
1623:
1614:
1612:
1608:
1604:
1603:KCNQ channels
1600:
1596:
1592:
1588:
1584:
1576:
1568:
1560:
1556:
1548:
1544:
1525:
1523:
1519:
1511:
1510:Na+/K+-ATPase
1507:
1503:
1499:
1495:
1481:
1479:
1475:
1470:
1468:
1467:basal ganglia
1465:
1461:
1458:
1450:
1446:
1442:
1438:
1434:
1431:and proximal
1430:
1422:
1419:
1415:
1407:
1403:
1399:
1395:
1391:
1387:
1383:
1379:
1375:
1371:
1367:
1348:
1346:
1343:
1335:
1331:
1317:
1315:
1304:
1300:
1292:
1288:
1281:
1267:
1265:
1257:
1253:
1251:
1247:
1243:
1240:and increase
1239:
1230:
1216:
1212:
1204:
1192:
1184:
1180:
1176:
1173:subtype is a
1168:
1151:
1149:
1141:
1133:
1130:
1126:
1122:
1118:
1103:
1098:
1094:
1090:
1087:
1083:
1076:
1074:
1071:
1067:
1063:
1059:
1056:
1052:
1048:
1041:
1039:
1033:
1029:
1026:
1020:
1018:
1012:
1008:
1005:
1001:
994:
992:
986:
982:
979:
973:
971:
965:
961:
958:
956:RefSeq (mRNA)
954:
947:
946:
941:
937:
934:
928:
927:
922:
918:
915:
913:
909:
902:
901:
896:
892:
889:
883:
882:
877:
873:
870:
868:
864:
857:
856:
851:
847:
844:
838:
837:
832:
828:
825:
823:
819:
816:
813:
811:
808:
804:
801:
797:
793:
786:
782:
777:
771:
768:
766:
763:
761:
758:
756:
753:
751:
748:
746:
743:
741:
738:
736:
733:
731:
728:
726:
723:
721:
718:
716:
713:
711:
708:
706:
705:wound healing
703:
701:
698:
696:
693:
691:
688:
686:
683:
681:
678:
676:
673:
671:
668:
666:
663:
661:
660:sensitization
658:
656:
653:
651:
648:
646:
643:
642:
640:
637:
636:
630:
627:
625:
622:
620:
617:
615:
612:
610:
607:
605:
602:
600:
597:
595:
592:
590:
587:
586:
584:
581:
580:
574:
571:
569:
566:
564:
561:
559:
556:
554:
551:
549:
546:
545:
543:
540:
539:
536:
535:Gene ontology
532:
528:
516:
511:
507:
502:
499:
497:
493:
485:
480:
469:
465:
461:
457:
453:
449:
445:
441:
437:
433:
432:
429:
425:
420:
417:
408:skin of thigh
407:
403:
399:
395:
391:
387:
383:
379:
375:
371:
370:
367:
363:
358:
355:
354:
351:
349:
345:
343:
342:
338:
337:
334:
332:
328:
324:
320:
316:
308:
303:
299:
295:
290:
280:
276:
269:
262:
256:
249:
241:
237:
233:
228:
224:
219:
215:
207:
202:
198:
194:
189:
179:
175:
168:
161:
155:
148:
144:
138:
134:
130:
125:
121:
116:
112:
108:
104:
100:
96:
92:
88:
84:
80:
76:
72:
64:
59:
52:
47:
42:
38:
33:
30:
19:
7665:
7632:
7605:Metabotropic
7469:
7354:
7307:
7265:
7231:
7202:
7173:
7018:
6643:
6492:
6443:Urotensin-II
6383:Somatostatin
6338:Prokineticin
6235:Melanocortin
5938:
5871:Neuropeptide
5810:Oxoglutarate
5652:
5614:Prostacyclin
5583:
5570:
5523:
5411:GHB receptor
5403:
5312:
5255:
4990:
4989:
4969:. Retrieved
4965:the original
4960:
4918:
4915:Hypertension
4914:
4875:
4871:
4830:
4826:
4792:(1): 124–6.
4789:
4785:
4744:
4740:
4707:
4703:
4667:
4664:J. Neurochem
4663:
4634:
4630:
4604:
4601:Biochemistry
4600:
4574:
4570:
4542:
4538:
4489:
4485:
4436:
4432:
4387:
4383:
4357:
4353:
4327:
4323:
4298:
4295:Physiol. Rev
4294:
4260:(2): 102–4.
4257:
4253:
4243:
4210:
4206:
4200:
4159:
4155:
4149:
4124:
4121:Biochemistry
4120:
4114:
4079:
4075:
4065:
4040:
4037:J. Med. Chem
4036:
3987:
3983:
3973:
3938:
3934:
3912:
3885:
3881:
3871:
3844:
3840:
3830:
3793:
3789:
3731:
3727:
3717:
3690:
3686:
3676:
3654:(2): 152–8.
3651:
3647:
3640:
3610:(3): 193–6.
3607:
3603:
3597:
3564:
3560:
3554:
3517:
3513:
3467:
3464:Neuroscience
3463:
3456:
3423:
3419:
3413:
3388:
3384:
3377:
3352:
3348:
3341:
3296:
3292:
3252:
3248:
3238:
3203:
3199:
3147:
3143:
3133:
3098:
3094:
3048:
3045:Hypertension
3044:
3014:10533/144001
2996:
2992:
2986:
2956:(1): 120–3.
2953:
2949:
2943:
2906:
2902:
2892:
2867:1959.4/53610
2849:
2845:
2835:
2802:
2798:
2761:(3): 510–6.
2758:
2754:
2747:
2715:(3): 586–9.
2712:
2708:
2666:
2662:
2614:
2610:
2550:
2546:
2490:
2486:
2480:
2447:
2443:
2437:
2396:
2392:
2355:
2351:
2341:
2332:
2323:
2314:
2305:
2233:
2218:animal model
2203:
2152:
2132:
2054:
1996:Stepholidine
1962:
1931:
1910:CD4+ T-cells
1899:
1849:
1820:hypertension
1809:
1777:
1770:population.
1757:
1727:burst firing
1720:
1674:
1655:
1615:
1536:
1522:hypertension
1487:
1471:
1421:interneurons
1394:hypothalamus
1359:
1324:In humans, D
1323:
1273:
1254:
1231:
1157:
1128:
1120:
1113:
1112:
1035:
1014:
988:
967:
943:
924:
898:
879:
853:
834:
814:
809:
404:hypothalamus
346:
339:
66:External IDs
29:
7313:Latrophilin
6448:Vasopressin
6433:Thyrotropin
6010:Angiotensin
5963:Neurotensin
5640:Cannabinoid
5619:Thromboxane
4827:J. Neurosci
3567:(1): 21–4.
3426:(1): 50–3.
2189:probes for
2183:mouse brain
2019:Antagonists
2013:Flupentixol
1971:receptors.
1868:recombinant
1768:Han Chinese
1747:flupentixol
1733:neurons in
1697:hippocampal
1684:risk factor
1587:consolidate
1418:cholinergic
1414:neostriatum
1382:hippocampus
1345:stop codons
1334:amino acids
1303:amino acids
1229:receptors.
1217:, and the D
446:vasculature
305:38,479,861
292:38,476,710
44:Identifiers
18:D5 receptor
7926:Categories
7903:Smoothened
7896:Smoothened
7819:Smoothened
7478:Calcitonin
6413:Tachykinin
6310:, but not
6304:Nociceptin
6170:Kisspeptin
6088:Endothelin
6051:Bradykinin
5939:Neuromedin
5516:Eicosanoid
5145:Purinergic
5077:Adrenergic
4971:4 December
4704:Nat. Genet
3931:receptors"
2300:, May 2017
2279:, May 2017
2256:References
2130:receptor.
2124:c-terminus
2105:c-terminus
2061:heteromers
2001:Fenoldopam
1991:SKF-83,959
1986:Rotigotine
1788:locomotion
1774:Locomotion
1545:in rodent
1460:astrocytes
1449:cerebellum
1402:cerebellum
1351:Expression
1299:C-terminus
1280:homologous
350:(ortholog)
204:9,784,009
191:9,781,634
87:HomoloGene
7813:Class F:
7612:pheromone
7608:glutamate
7032:Olfactory
6068:Chemokine
5850:Succinate
5635:Bile acid
5443:Melatonin
5416:Histamine
5256:(all but
5248:Serotonin
5153:Adenosine
5055:Rhodopsin
4786:Neurology
4732:195213008
3470:: 11–20.
3391:(1): 57.
2507:0022-3042
2232:receptor
2222:loxP site
2097:arginines
2069:receptors
2045:SCH 23390
1891:miRNA 29a
1800:wild type
1786:-induced
1689:rat model
1665:haplotype
1647:Addiction
1607:M current
1433:dendrites
1252:neurons.
1038:NP_038531
1017:NP_000789
991:NM_013503
970:NM_000798
800:Orthologs
95:GeneCards
7837:Frizzled
7830:Frizzled
7815:Frizzled
7657:, type 2
7563:Secretin
7503:Glucagon
7208:Cadherin
7166:Adhesion
7153:Secretin
6486:, bitter
6333:Oxytocin
6030:Bombesin
5678:Estrogen
5379:Dopamine
4937:12623966
4902:12509874
4859:12351722
4814:33503277
4806:11781417
4769:10659839
4724:10391209
4694:35877239
4631:Genomics
4354:Genomics
4324:Genomics
4276:11857790
4235:11317445
4227:20684667
4184:10659839
4141:12234176
4106:19171671
4057:16539400
4014:25231919
3965:25339241
3904:22379034
3863:25127864
3822:12486173
3768:24155877
3728:PLOS ONE
3709:24668635
3668:11304828
3632:44740438
3624:14732464
3589:43454552
3581:11445276
3546:24027284
3492:25731931
3484:23541742
3440:18164132
3405:19125111
3369:11353446
3333:24843151
3271:10816588
3230:24478341
3176:13679419
3125:24500688
3023:23701196
2978:34954571
2970:15533323
2884:25057196
2876:23674405
2819:22610946
2755:Genomics
2739:23318175
2641:22827965
2523:84297833
2464:21303898
2352:Genomics
2296:–
2275:–
2244:See also
2234:in vitro
2210:C57BL/6J
2206:knockout
2179:antisera
2175:peptides
2139:interact
2126:of the D
1975:Agonists
1860:NK cells
1846:Immunity
1836:renalase
1628:between
1567:amygdala
1555:receptor
1547:striatum
1518:renalase
1457:striatal
1437:neuropil
1406:midbrain
1390:thalamus
1386:striatum
1374:amygdala
1342:in-frame
1264:agonists
1256:In vitro
1215:dopamine
1193:. Both D
1154:Function
1086:Wikidata
779:Sources:
720:learning
594:membrane
400:appendix
7626:, sweet
7601:Class C
7533:PACAPR1
7149:Class B
6358:Relaxin
6280:Motilin
6165:Ghrelin
6130:Galanin
5863:Peptide
5051:Class A
4893:4048549
4850:6757796
4777:4415918
4749:Bibcode
4686:9603210
4651:8288248
4621:7727453
4591:7633397
4561:1834671
4526:1833775
4494:Bibcode
4473:1831904
4441:Bibcode
4420:4373022
4412:1826762
4392:Bibcode
4374:1532789
4344:1387108
4315:9457173
4254:Genesis
4192:4415918
4164:Bibcode
4097:2684927
4005:5234683
3956:4314200
3813:6758465
3759:3796526
3736:Bibcode
3537:6705171
3448:7548859
3324:4050601
3301:Bibcode
3221:3905134
3167:6740372
3116:3949042
3067:9719042
2935:8613722
2926:6577925
2775:1532789
2730:3744868
2685:7525564
2632:3802523
2587:1833775
2555:Bibcode
2472:2545878
2429:4373022
2421:1826762
2401:Bibcode
2372:1774076
2298:Ensembl
2277:Ensembl
2212:mice. D
2085:calcium
1928:Ligands
1885:, from
1652:Smoking
1626:synapse
1624:at the
1494:kidneys
1462:of the
1439:in the
1282:to the
1125:protein
1123:, is a
912:UniProt
867:Ensembl
806:Species
785:QuickGO
325:pattern
51:Aliases
7817:&
7746:GPRC6A
7483:CALCRL
7347:Orphan
6636:Orphan
6627:type 1
6318:Orexin
6306:&
6285:Opioid
6025:Apelin
4986:(MeSH)
4935:
4900:
4890:
4857:
4847:
4812:
4804:
4775:
4767:
4741:Nature
4730:
4722:
4692:
4684:
4649:
4619:
4589:
4559:
4524:
4514:
4471:
4461:
4418:
4410:
4384:Nature
4372:
4342:
4313:
4274:
4233:
4225:
4190:
4182:
4156:Nature
4139:
4104:
4094:
4055:
4012:
4002:
3963:
3953:
3902:
3861:
3820:
3810:
3766:
3756:
3707:
3666:
3630:
3622:
3587:
3579:
3544:
3534:
3490:
3482:
3446:
3438:
3403:
3367:
3331:
3321:
3269:
3228:
3218:
3174:
3164:
3123:
3113:
3065:
3021:
2976:
2968:
2933:
2923:
2882:
2874:
2827:895006
2825:
2817:
2773:
2737:
2727:
2683:
2639:
2629:
2585:
2575:
2521:
2515:212530
2513:
2505:
2470:
2462:
2427:
2419:
2393:Nature
2370:
2143:GABRG2
1840:sodium
1735:6-OHDA
1638:murine
1498:sodium
1484:Kidney
1447:, and
1404:, and
1301:of 93
1072:search
1070:PubMed
945:Q8BLD9
926:P21918
822:Entrez
629:cilium
496:BioGPS
462:embryo
454:embryo
183:4p16.1
75:126453
7666:Other
7633:TAS1R
7624:Taste
7522:GLP2R
7517:GLP1R
7470:Other
7335:ELTD1
7308:ADGRL
7266:ADGRG
7232:ADGRE
7203:ADGRC
7174:ADGRB
7155:-like
7037:Opsin
7019:Other
6493:TAS2R
6484:Taste
6312:Sigma
6294:Kappa
6289:Delta
5997:C5a (
5982:Other
5628:Other
5556:FPRL1
5524:CysLT
5342:Other
5293:5-HT2
5263:5-HT1
5258:5-HT3
5057:-like
4810:S2CID
4773:S2CID
4728:S2CID
4690:S2CID
4517:52675
4464:52326
4416:S2CID
4231:S2CID
4188:S2CID
3927:and D
3628:S2CID
3585:S2CID
3488:S2CID
3444:S2CID
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