33:
317:
with the capability of changing the hydrophobicity of a surface and thus causing small droplets of liquid to move up hill, against the force of gravity. In 2009 he reported the first small-molecule walker-track system in which a 'walker' can be transported directionally along a short molecular track
346:
and demonstrated a small-molecule 'robotic arm' able to transport molecular fragments between sites 2 nm apart on a molecular platform, marking the start of so-called 'small-molecule robotics'. In 2017 the Leigh group reported the first molecular robot that can be programmed to build different
1189:
August, David P.; Dryfe, Robert A. W.; Haigh, Sarah J.; Kent, Paige R. C.; Leigh, David A.; Lemonnier, Jean-François; Li, Zheling; Muryn, Christopher A.; Palmer, Leoni I.; Song, Yiwei; Whitehead, George F. S.; Young, Robert J. (December 2020).
338:). In 2013 the Leigh group reported a small-molecule machine capable of detaching and assembling a series of amino acid building blocks from a track into a peptide of specific sequence, a very primitive version of the task performed by the
1061:
1191:
1112:
318:
in a manner reminiscent of the way that biological motor proteins 'walk' along biopolymers in the cell. In 2011 his research group described the smallest molecular knot prepared to date (a 76-atom-loop
871:
351:'. The achievement was hailed as 'science fiction becomes fact'. In 2020 the Leigh group described the 2D weaving of polymer chains, resulting in a molecularly-woven fabric with a
358:
In
September 2016 Leigh was suggested as one of three candidates for the potential award of a Nobel Prize for synthetic molecular machines. However, on 5 October 2016 the
934:
421:
player and an accomplished magician (ex-Edinburgh Magic Circle and the
Manchester Circle of Magicians), known for blending magic and science in his public lectures.
870:
Danon, Jonathan J.; Krüger, Anneke; Leigh, David A.; Lemonnier, Jean-François; Stephens, Alexander J.; Vitorica-Yrezabal, Iñigo J.; Woltering, Steffen L. (2017).
347:
molecules. The molecular robot could be programmed to construct any one of four different stereoisomers of a molecular product, a significant step towards a '
1819:
933:
Leigh, David A.; Danon, Jonathan J.; Fielden, Stephen D. P.; Lemonnier, Jean-François; Whitehead, George F. S.; Woltering, Steffen L. (14 December 2020).
2184:
2174:
2154:
2194:
247:
302:
2199:
2189:
286:
He is noted for the invention of fundamental methods to control molecular-level dynamics and entanglement, including strategies to construct
1551:
1713:
1569:
600:
1587:
474:
1497:
190:
1404:
231:
121:
786:; McGonigal, P. R.; Symes, M. D.; Wu, J.; Zengerle, M. (2011). "Active-Metal Template Synthesis of a Molecular Trefoil Knot".
2164:
2159:
1770:
468:
718:
999:
1249:
998:
Wilson, Miriam R.; Solà, Jordi; Carlone, Armando; Goldup, Stephen M.; Lebrasseur, Nathalie; Leigh, David A. (June 2016).
1461:
1358:"Leigh and the first two recipients of the 'Professor David Leigh Prize for Chemistry' at Codsall Community High School"
1802:
530:
243:
1429:
440:
1641:
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encourages girls and disadvantaged children to study science at university. Leigh is a
Director and Governor of
1483:
391:
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1479:
1275:
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2044:
1731:
407:
271:
1623:
1883:
506:
399:
310:
132:
1811:
411:
225:
116:
1422:
1382:
1735:
1681:
1645:
1627:
1465:
1447:
1408:
540:
527:
447:
431:
137:
2179:
1981:
1591:
1573:
1555:
487:
343:
839:
764:
2133:
1873:
1833:
1327:
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298:
and some of the earliest synthetic molecular motors, molecular robots and functional nanomachines.
251:
169:
155:
1302:
465:
Royal
Society of Chemistry-Real Sociedad Española de Química (RSC-RSEQ) Prize for Chemistry (2007)
1913:
1537:
1335:
1245:
579:
536:
International
Society for Nanoscale Science, Computation and Engineering Nanoscience Prize (2019)
406:, describing the science behind nanorobotics. The ‘Professor David Leigh Prize for Chemistry’ at
275:
255:
173:
83:
663:"Photoinduction of Fast, Reversible Translational Motion in a Hydrogen-Bonded Molecular Shuttle"
2169:
1795:
1780:
834:
568:
1357:
825:; McBurney, R. T.; Rissanen, K.; Schultz, D. (2011). "A synthetic molecular pentafoil knot".
259:
177:
2204:
1203:
1171:
1124:
1073:
1014:
883:
674:
1505:
750:
305:
he prepared a novel molecular information ratchet that employs a mechanism reminiscent of
8:
2015:
1501:
371:
348:
1207:
1128:
1077:
1062:"Pick-up, transport and release of a molecular cargo using a small-molecule robotic arm"
1018:
980:
887:
678:
2117:
2066:
1993:
1976:
1971:
1227:
1148:
1038:
962:
915:
700:
601:"Leading scientists awarded Royal Society Research Professorships | Royal Society"
363:
306:
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1788:
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1605:
1231:
1219:
1152:
1140:
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919:
907:
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803:
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639:
574:
515:
375:
159:
106:
1042:
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1947:
1935:
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1211:
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1081:
1022:
946:
891:
844:
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682:
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314:
722:
586:
2107:
2032:
2005:
1888:
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481:
418:
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326:(five crossing points). The Leigh group have also reported the synthesis of an 8
2112:
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1923:
1918:
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950:
403:
331:
323:
102:
1527:
1254:
1215:
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1815:
1717:
1663:
1609:
1443:
903:
622:; Zerbetto, F. (2007). "Synthetic Molecular Motors and Mechanical Machines".
521:
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239:
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687:
662:
191:
The synthesis and properties of novel and natural macrocyclic trichothecenes
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1999:
1987:
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1953:
1941:
1929:
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of 40-60 million (the finest
Egyptian linen has a thread count of ~1500).
2102:
2054:
2027:
2010:
1868:
1853:
1771:"National achievement highlighted by Royal Society of Edinburgh's medals"
367:
32:
1136:
1026:
1903:
1085:
848:
63:
1192:"Self-assembly of a layered two-dimensional molecularly woven fabric"
395:
309:(although it requires an energy input and so does not challenge the
1423:"THE INSTITUTE OF CHEMISTRY OF IRELAND ANNUAL AWARDS FOR CHEMISTRY"
1328:"Nanobot (Havana Parody) - A Capella Science ft. Dorothy Andrusiak"
339:
291:
287:
98:
94:
1714:"Leading scientists awarded Royal Society Research Professorships"
1168:"Science fiction becomes fact: a machine that assembles molecules"
1532:
1259:
1175:
1113:"Stereodivergent synthesis with a programmable molecular machine"
254:. He was previously the Forbes Chair of Organic Chemistry at the
235:
1810:
661:; Mottier, L.; Paolucci, F.; Roffia, S.; Wurpel, G. W. (2001).
184:
342:. They also invented the first autonomous chemically-fuelled
228:
932:
719:"Leigh's Group's illustrated explanation of the "ratchet""
462:
Royal
Society of Chemistry Award for Nanotechnology (2005)
1055:
869:
334:
made to date, and a molecular endless knot (the smallest
656:
258:(2001–2012) and Professor of Synthetic Chemistry at the
1000:"An autonomous chemically fuelled small-molecule motor"
997:
210:
981:"Tiny molecular machine apes cellular production line"
820:
781:
1732:"RSC Perkin Prize for Organic Chemistry 2017 Winner"
1696:"Academy of Europe: Leigh David - Academia Europaea"
1188:
1106:
1757:"2019 ISNSCE Nanoscience Prize – Prof. David Leigh"
567:
322:– three crossing points) and also a 160-atom-loop
1255:"Who will win the 2016 Nobel Prize in Chemistry?"
394:. In 2018 he commissioned ‘Nanobot’, a parody by
313:). He has developed a rotaxane based photoactive
2146:
1111:; Marcos, V.; Palmer, L. I.; Pisano, S. (2017).
872:"Braiding a molecular knot with eight crossings"
617:
303:mechanically-interlocked molecular architectures
437:Fellow of the Royal Society of Chemistry (2004)
765:"'Two-legged' molecular walker takes a stroll"
582: ed.). Oxford: A & C Black.
512:Royal Society of Chemistry Pedler Award (2014)
503:Royal Society of Chemistry Tilden Prize (2010)
1796:
1480:"Izatt-Christensen Award Goes to David Leigh"
739:. 1 February 2007 – via news.bbc.co.uk.
500:Royal Society of Chemistry Merck Award (2009)
1383:"National Pairs - Winners - Scotsman Trophy"
753:. 29 August 2005 – via news.bbc.co.uk.
1267:
782:Barran, P. E.; Cole, H. L.; Goldup, S. M.;
657:Brouwer, A. M.; Frochot, C.; Gatti, F. G.;
1803:
1789:
475:Foresight Nanotech Institute Feynman Prize
31:
2185:Fellows of the Royal Society of Chemistry
2175:Academics of the University of Manchester
2155:Fellows of the Royal Society of Edinburgh
838:
686:
562:
560:
558:
434:Award for Supramolecular Chemistry (2003)
2195:Academics of the University of Edinburgh
1724:
1498:"2007 Foresight Institute Feynman Prize"
1165:
459:EPSRC Senior Research Fellow (2005–2010)
242:Research Professor and, since 2014, the
788:Angewandte Chemie International Edition
624:Angewandte Chemie International Edition
2200:Academics of the University of Warwick
2147:
1540:from the original on 21 December 2021.
711:
555:
490:Advanced Grants (2008 , 2013 and 2017)
281:
2190:Alumni of the University of Sheffield
1784:
1444:"Professor David Alan Leigh FRS FRSE"
1338:from the original on 21 December 2021
1273:
469:International Izatt-Christensen Award
424:
1405:"RSC Supramolecular Chemistry Award"
1303:"Guinness World Records certificate"
1060:; Markevicius, A.; Solá, J. (2016).
456:-Wolfson Research Merit Award (2005)
417:Leigh is a former national champion
390:molecular knot features in the 2019
381:
1276:"The Nobel Prize in Chemistry 2016"
751:"Nanotech team move water droplets"
737:"Tiny engine boosts nanotech hopes"
13:
531:Perkin Prize for Organic Chemistry
244:Sir Samuel Hall Chair of Chemistry
14:
2216:
1430:Institute of Chemistry of Ireland
935:"A molecular endless (7 4 ) knot"
443:Annual Award for Chemistry (2005)
441:Institute of Chemistry of Ireland
374:for the design and synthesis of
1763:
1749:
1706:
1688:
1670:
1652:
1634:
1616:
1598:
1580:
1562:
1544:
1520:
1490:
1484:Chemical & Engineering News
1472:
1454:
1436:
1415:
1397:
1375:
1350:
1320:
1295:
1238:
1182:
1166:@NatureNV (21 September 2017).
1159:
1100:
1049:
991:
973:
926:
863:
814:
471:in Macrocyclic Chemistry (2007)
1678:"RSC Pedler Award 2014 Winner"
1642:"RSC Tilden Prize 2010 Winner"
775:
757:
743:
729:
650:
611:
593:
392:Guinness Book of World Records
128:Izatt-Christensen Award (2007)
1:
1660:"Making the tiniest machines"
1624:"RSC Merck Award 2009 winner"
548:
408:Codsall Community High School
272:Codsall Community High School
2165:Members of Academia Europaea
2160:Fellows of the Royal Society
1107:Kassem, S.; Lee, A. T. L..;
1056:Kassem, S.; Lee, A. T. L..;
587:UK public library membership
507:Royal Society Bakerian Medal
311:second law of thermodynamics
265:
133:Royal Society Bakerian Medal
7:
1606:"Professor David Leigh FRS"
1385:. The Scottish Bridge Union
821:Ayme, J. F.; Beves, J. E.;
10:
2221:
1736:Royal Society of Chemistry
1682:Royal Society of Chemistry
1646:Royal Society of Chemistry
1628:Royal Society of Chemistry
1588:"ERC FUNDED PROJECTS 2017"
1570:"ERC FUNDED PROJECTS 2013"
1552:"ERC FUNDED PROJECTS 2008"
1466:Royal Society of Chemistry
1462:"RSC Nanotechnology Award"
1448:Royal Society of Edinburgh
1409:Royal Society of Chemistry
951:10.1038/s41557-020-00594-x
541:Royal Society of Edinburgh
528:Royal Society of Chemistry
448:Royal Society of Edinburgh
432:Royal Society of Chemistry
138:Royal Society of Edinburgh
2126:
2075:
1826:
1592:European Research Council
1574:European Research Council
1556:European Research Council
1216:10.1038/s41586-020-3019-9
578:. Vol. 2016 (online
569:"LEIGH, Prof. David Alan"
524:Research Professor (2016)
488:European Research Council
344:synthetic molecular motor
205:
201:
183:
165:
151:
144:
112:
90:
79:
71:
42:
30:
23:
2134:William, Prince of Wales
1274:Staff (5 October 2016).
412:Withington Girls' School
360:Nobel Prize in Chemistry
252:University of Manchester
170:University of Manchester
156:Supramolecular chemistry
896:10.1126/science.aal1619
688:10.1126/science.1057886
580:Oxford University Press
330:knot, the most complex
276:University of Sheffield
256:University of Edinburgh
248:Department of Chemistry
174:University of Edinburgh
84:University of Sheffield
1528:"Descartes Prize 2007"
800:10.1002/anie.201105012
636:10.1002/anie.200504313
270:Leigh was educated at
260:University of Warwick
178:University of Warwick
126:Feynman Prize (2007)
2016:Henning Sirringhaus
1773:. 9 September 2021.
1502:Foresight Institute
1208:2020Natur.588..429A
1137:10.1038/nature23677
1129:2017Natur.549..374K
1078:2016NatCh...8..138K
1027:10.1038/nature18013
1019:2016Natur.534..235W
888:2017Sci...355..159D
794:(51): 12280–12284.
771:. 21 December 2009.
679:2001Sci...291.2124B
673:(5511): 2124–2128.
484:for Research (2007)
372:Jean-Pierre Sauvage
349:molecular assembler
282:Career and research
130:Perkin Prize (2017)
2118:Steven D. Tanksley
1994:Richard Passingham
1977:Arthur B. McDonald
1930:Christopher Hunter
1086:10.1038/nchem.2410
987:. 11 January 2013.
849:10.1038/nchem.1193
725:on 20 August 2008.
425:Awards and honours
376:molecular machines
364:J. Fraser Stoddart
140:Royal Medal (2021)
107:Molecular machines
2142:
2141:
2098:Roger D. Kornberg
2088:H. Robert Horvitz
2045:Jonathan Tennyson
1954:Dimitris Kioussis
1700:Academia Europaea
1202:(7838): 429–435.
1123:(7672): 374–378.
1013:(7606): 235–240.
882:(6321): 159–162.
585:(Subscription or
516:Academia Europaea
382:Public engagement
219:
218:
160:Organic chemistry
146:Scientific career
2212:
2180:British chemists
2039:Jesper Svejstrup
2022:Maurice Skolnick
1948:Jonathan Keating
1936:Graham Hutchings
1909:Nicholas Harberd
1839:Ross J. Anderson
1834:Robert Ainsworth
1805:
1798:
1791:
1782:
1781:
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1614:
1613:
1602:
1596:
1595:
1584:
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1577:
1566:
1560:
1559:
1548:
1542:
1541:
1524:
1518:
1517:
1515:
1513:
1504:. Archived from
1494:
1488:
1487:
1476:
1470:
1469:
1458:
1452:
1451:
1440:
1434:
1433:
1427:
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1281:Nobel Foundation
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1180:
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1156:
1104:
1098:
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1066:Nature Chemistry
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1046:
1004:
995:
989:
988:
977:
971:
970:
939:Nature Chemistry
930:
924:
923:
867:
861:
860:
842:
827:Nature Chemistry
818:
812:
811:
779:
773:
772:
761:
755:
754:
747:
741:
740:
733:
727:
726:
721:. Archived from
715:
709:
708:
690:
654:
648:
647:
615:
609:
608:
605:royalsociety.org
597:
591:
590:
583:
571:
564:
315:molecular switch
222:David Alan Leigh
215:
212:
197:
60:
56:
54:
47:David Alan Leigh
35:
21:
20:
2220:
2219:
2215:
2214:
2213:
2211:
2210:
2209:
2145:
2144:
2143:
2138:
2122:
2108:Joseph Stiglitz
2071:
2033:Malcolm Stevens
2006:Wolfram Schultz
1889:James Gimzewski
1864:Michel Chrétien
1844:Michael Ashfold
1822:
1809:
1779:
1778:
1769:
1768:
1764:
1759:. 8 April 2020.
1755:
1754:
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1712:
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1694:
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1635:
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1603:
1599:
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1581:
1568:
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1563:
1550:
1549:
1545:
1526:
1525:
1521:
1511:
1509:
1508:on 12 June 2018
1496:
1495:
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1473:
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1442:
1441:
1437:
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1402:
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1366:
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1341:
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1326:
1325:
1321:
1311:
1309:
1301:
1300:
1296:
1286:
1284:
1272:
1268:
1253:
1250:Wayback Machine
1243:
1239:
1187:
1183:
1164:
1160:
1105:
1101:
1054:
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1002:
996:
992:
979:
978:
974:
931:
927:
868:
864:
840:10.1.1.663.4543
819:
815:
780:
776:
769:Chemistry World
763:
762:
758:
749:
748:
744:
735:
734:
730:
717:
716:
712:
655:
651:
630:(1–2): 72–191.
616:
612:
599:
598:
594:
584:
566:
565:
556:
551:
546:
482:Descartes Prize
477:(Theory) (2007)
427:
419:contract bridge
396:acapellascience
389:
384:
362:was awarded to
329:
307:Maxwell's demon
296:molecular knots
284:
268:
209:
195:
176:
172:
158:
136:
131:
129:
127:
125:
120:
103:Molecular knots
80:Alma mater
67:
61:
58:
52:
50:
49:
48:
38:
26:
17:
16:British chemist
12:
11:
5:
2218:
2208:
2207:
2202:
2197:
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2187:
2182:
2177:
2172:
2167:
2162:
2157:
2140:
2139:
2137:
2136:
2130:
2128:
2124:
2123:
2121:
2120:
2115:
2113:Rashid Sunyaev
2110:
2105:
2100:
2095:
2093:Thomas Kailath
2090:
2085:
2079:
2077:
2073:
2072:
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2069:
2064:
2057:
2052:
2047:
2042:
2035:
2030:
2025:
2018:
2013:
2008:
2003:
2000:Guy Richardson
1996:
1991:
1984:
1979:
1974:
1969:
1964:
1961:Stephen Larter
1957:
1950:
1945:
1942:Peter Isaacson
1938:
1933:
1926:
1924:Christine Holt
1921:
1919:Brian Hemmings
1916:
1911:
1906:
1901:
1896:
1891:
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1841:
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1705:
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1669:
1651:
1633:
1615:
1597:
1579:
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1519:
1489:
1471:
1453:
1435:
1414:
1396:
1374:
1349:
1319:
1294:
1266:
1237:
1181:
1174:) – via
1158:
1099:
1072:(2): 138–143.
1048:
990:
972:
945:(2): 117–122.
925:
862:
813:
774:
756:
742:
728:
710:
649:
610:
592:
553:
552:
550:
547:
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537:
534:
525:
519:
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510:
504:
501:
498:
493:Fellow of the
491:
485:
478:
472:
466:
463:
460:
457:
451:
446:Fellow of the
444:
438:
435:
428:
426:
423:
404:Camila Cabello
387:
383:
380:
332:molecular knot
327:
324:pentafoil knot
283:
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2055:Burt Totaro
2028:Karen Steel
2011:Keith Shine
1967:David Leigh
1869:Jenny Clack
1854:Martin Buck
1362:twitter.com
1332:youtube.com
368:Ben Feringa
72:Nationality
57:31 May 1963
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1988:David Owen
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589:required.)
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236:chemist
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