808:
820:
394:. These channels are found predominantly in smaller sensory neurons in the dorsal root ganglion cells and are activated by higher pressures, two attributes that are characteristic of nociceptors. Also, the threshold of HT channels was lowered in the presence of PGE2 (a compound that sensitizes neurons to mechanical stimuli and mechanical hyperalgesia) which further supports a role for HT channels in the transduction of mechanical stimuli into nociceptive neuronal signals.
832:
40:
67:
381:
have been found in the posterior root ganglion neurons. The two channels are broadly classified as either high-threshold (HT) or low threshold (LT). As their names suggest, they have different thresholds as well as different sensitivities to pressure. These are cationic channels whose activity
382:
appears to be regulated by the proper functioning of the cytoskeleton and cytoskeleton associated proteins. The presence of these channels in the posterior root ganglion gives reason to believe that other sensory neurons may contain them as well.
661:
Sugawara, O.; Atsuta, Y.; Iwahara, T.; Muramoto, T.; Watakabe, M.; Takemitsu, Y. (1996). "The effects of mechanical compression and hypoxia on nerve root and dorsal root ganglia. An analysis of ectopic firing using an in vitro model".
362:
The nerve endings of dorsal root ganglion neurons have a variety of sensory receptors that are activated by mechanical, thermal, chemical, and noxious stimuli. In these sensory neurons, a group of
290:
The distal section of the axon may either be a bare nerve ending or encapsulated by a structure that helps relay specific information to nerve. Two examples where the nerve ending of the
370:
transduction have been identified. Compression of the dorsal root ganglion by a mechanical stimulus lowers the voltage threshold needed to evoke a response and causes
875:
456:(also known as sensory ganglionopathy): A heterogenous group of causes leading to nerves in the dorsal root ganglion being destroyed causing sensory symptoms.
152:
497:
Purves, Dale; Augustine, George J.; Fitzpatrick, David; Katz, Lawrence C.; LaMantia, Anthony-Samuel; McNamara, James O.; Williams, S. Mark (2001).
819:
848:
860:
128:
347:
903:
71:
A spinal nerve with its ventral and dorsal roots. The dorsal root ganglion is the "spinal ganglion", following the dorsal root.
705:
Syriatowicz, J. P.; Hu, D.; Walker, J. S.; Tracey, D. J. (1999). "Hyperalgesia due to nerve injury: Role of prostaglandins".
334:. Hence, the spinal ganglia can be regarded as gray matter of the spinal cord that became translocated to the periphery.
17:
318:. The anterior and posterior spinal nerve roots join just beyond (lateral) to the location of the dorsal root ganglion.
1727:
831:
402:
The presynaptic regulation of the dorsal nerve ending discharge in the spinal cord can occur through certain types of
536:
1527:
1457:
748:
Lorenzo LE, Godin AG, Wang F, St-Louis M, Carbonetto S, Wiseman PW, Ribeiro-da-Silva A, De
Koninck Y (June 2014).
1522:
1452:
1067:
807:
247:
type, meaning they have a cell body (soma) with two branches that act as a single axon, often referred to as a
1142:
443:
279:
147:
1137:
1125:
896:
527:
378:
1177:
1115:
750:"Gephyrin Clusters Are Absent from Small Diameter Primary Afferent Terminals Despite the Presence of GABA
1172:
499:"The Major Afferent Pathway for Mechanosensory Information: The Dorsal Column-Medial Lemniscus System"
1682:
1532:
1467:
1095:
220:
1462:
1188:
295:
111:
1161:
889:
315:
1629:
1156:
920:
549:
259:
244:
224:
159:
135:
123:
1722:
1487:
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1412:
864:
854:
1612:
1509:
1439:
1265:
869:
453:
367:
216:
8:
1652:
1497:
1492:
1027:
960:
303:
205:
49:
550:"Nociceptors of dorsal root ganglion express proton-sensing G-protein-coupled receptors"
1687:
1657:
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1557:
1547:
1542:
1537:
1482:
1258:
1168:
1022:
780:
749:
730:
687:
633:
624:
608:
580:
718:
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1662:
1647:
1552:
1417:
1198:
1150:
955:
950:
785:
722:
679:
675:
638:
572:
532:
275:
734:
691:
584:
1639:
1602:
1597:
945:
775:
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714:
671:
628:
620:
564:
423:
411:
371:
263:
1407:
1376:
1371:
1253:
1248:
1072:
116:
1697:
1667:
1624:
1444:
1402:
1380:
1300:
1183:
1007:
912:
522:
498:
415:
403:
568:
374:
to be fired. This firing may even persist after the removal of the stimulus.
1716:
1346:
1331:
1012:
140:
53:
609:"Mechanosensitive ion channels in cultured sensory neurons of neonatal rats"
270:
in the periphery, bypass the cell body, and continue to propagate along the
1592:
1514:
1427:
1308:
1238:
1017:
940:
789:
726:
642:
576:
350:
are expressed by DRG sensory neurons and might play a role in acid-induced
327:
201:
87:
683:
1607:
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1211:
1032:
970:
965:
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427:
391:
363:
351:
331:
232:
197:
473:
165:
1677:
1366:
1243:
1206:
825:
The formation of the spinal nerve from the posterior and anterior roots
223:, afferents refer to the axons that relay sensory information into the
82:
1692:
1077:
1050:
448:
1356:
1341:
1336:
1060:
1055:
982:
977:
193:
56:
1619:
1580:
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881:
189:
39:
1279:
1234:
999:
45:
548:
Huang CW, Tzeng JN, Chen YJ, Tsai WF, Chen CC, Sun WH (2007).
496:
660:
228:
212:
99:
1318:
1226:
1042:
607:
Cho, H.; Shin, J.; Shin, C. Y.; Lee, S. Y.; Oh, U. (2002).
431:
385:
243:
The neurons comprising the dorsal root ganglion are of the
302:
of mechanosensory neurons sensitive to stroking only, and
66:
704:
747:
857: – Histology Learning System at Boston University
851:
at Human
Anatomy Online, SUNY Downstate Medical Center
266:
in posterior root ganglion neuron may initiate in the
48:(around stage of day 7) after incubation overnight in
414:
which are absent from these types of terminals. Thus
27:
Cluster of neurons in a dorsal root of a spinal nerve
531:, 4th ed., p.431–433. McGraw-Hill, New York (2000).
837:
Scheme showing structure of a typical spinal nerve.
326:The dorsal root ganglia develop in the embryo from
59:. Neurites growing out of the ganglion are visible.
547:
306:, which make neurons more sensitive to vibration.
1714:
390:High-threshold channels have a possible role in
606:
602:
600:
598:
596:
594:
204:. The cell bodies of sensory neurons known as
897:
656:
654:
652:
215:of dorsal root ganglion neurons are known as
357:
258:Unlike the majority of neurons found in the
44:A dorsal root ganglion (DRG) from a chicken
741:
591:
541:
904:
890:
649:
348:Proton-sensing G protein-coupled receptors
65:
38:
779:
769:
632:
208:are located in the dorsal root ganglia.
386:High-threshold mechanosensitive channels
14:
1715:
397:
885:
799:
490:
314:The dorsal root ganglia lie in the
24:
911:
625:10.1523/JNEUROSCI.22-04-01238.2002
410:but not through the activation of
25:
1739:
842:
285:
105:ganglion sensorium nervi spinalis
830:
818:
806:
676:10.1097/00007632-199609150-00006
1068:Oligodendrocyte progenitor cell
771:10.1523/JNEUROSCI.0159-14.2014
698:
516:
466:
366:thought to be responsible for
342:
321:
13:
1:
719:10.1016/S0306-4522(99)00365-6
460:
444:Anterior root of spinal nerve
379:mechanosensitive ion channels
294:is encapsulated as such are,
280:posterior horn of spinal cord
528:Principles of Neural Science
426:can presynaptically control
238:
7:
1178:Postganglionic nerve fibers
613:The Journal of Neuroscience
525:, Schwartz JH, Jessell TM.
437:
337:
309:
10:
1744:
1173:Preganglionic nerve fibers
1728:Peripheral nervous system
1683:Olfactory receptor neuron
1638:
1579:
1572:
1508:
1438:
1395:
1355:
1347:Neurofibril/neurofilament
1317:
1299:
1292:
1278:
1225:
1197:
1103:
1094:
1041:
998:
991:
928:
919:
855:Histology image: 04401loa
569:10.1016/j.mcn.2007.06.010
503:Neuroscience. 2nd edition
358:Mechanosensitive channels
221:peripheral nervous system
158:
146:
134:
122:
110:
98:
93:
81:
76:
64:
37:
32:
849:Anatomy figure: 02:04-09
316:intervertebral foramina
186:posterior root ganglion
1630:Neuromuscular junction
1493:III or Aδ or fast pain
377:Two distinct types of
260:central nervous system
225:central nervous system
160:Anatomical terminology
865:Ohio State University
296:Meissner's corpuscles
1648:Meissner's corpuscle
1613:Postsynaptic density
1510:Efferent nerve fiber
1498:IV or C or slow pain
1440:Afferent nerve fiber
1266:Satellite glial cell
454:Sensory neuronopathy
178:dorsal root ganglion
33:Dorsal root ganglion
1653:Merkel nerve ending
557:Mol. Cell. Neurosci
398:Presynaptic control
304:Pacinian corpuscles
298:, which render the
274:until reaching the
206:first-order neurons
18:Dorsal root ganglia
1688:Photoreceptor cell
1658:Pacinian corpuscle
1589:Electrical synapse
1543:Lower motor neuron
1538:Upper motor neuron
1259:Internodal segment
1199:Connective tissues
1169:Autonomic ganglion
188:) is a cluster of
184:; also known as a
52:stained with anti-
1710:
1709:
1706:
1705:
1673:Free nerve ending
1640:Sensory receptors
1568:
1567:
1483:Ib or Golgi or Aα
1391:
1390:
1274:
1273:
1151:Ramus communicans
1090:
1089:
1086:
1085:
956:Commissural fiber
951:Association fiber
946:Projection fibers
872:at webanatomy.net
800:Additional images
670:(18): 2089–2094.
424:glycine receptors
412:glycine receptors
372:action potentials
276:synaptic terminal
174:
173:
169:
50:NGF growth medium
16:(Redirected from
1735:
1603:Synaptic vesicle
1598:Chemical synapse
1577:
1576:
1297:
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1289:
1101:
1100:
996:
995:
926:
925:
906:
899:
892:
883:
882:
834:
822:
813:Medulla spinalis
810:
794:
793:
783:
773:
745:
739:
738:
702:
696:
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658:
647:
646:
636:
619:(4): 1238–1247.
604:
589:
588:
554:
545:
539:
520:
514:
513:
511:
509:
494:
488:
487:
485:
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300:distal processes
272:proximal process
264:action potential
253:proximal process
166:edit on Wikidata
163:
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1488:II or Aβ and Aγ
1443:
1434:
1387:
1377:Apical dendrite
1372:Dendritic spine
1351:
1313:
1283:
1270:
1254:Node of Ranvier
1249:Myelin incisure
1221:
1193:
1082:
1073:Oligodendrocyte
1056:Ependymal cells
1037:
987:
915:
910:
845:
838:
835:
826:
823:
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797:
764:(24): 8300–17.
753:
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245:pseudo-unipolar
241:
182:spinal ganglion
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28:
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15:
12:
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5:
1741:
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1700:
1698:Taste receptor
1695:
1690:
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1668:Muscle spindle
1665:
1663:Ruffini ending
1660:
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1625:Ribbon synapse
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1445:Sensory neuron
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1415:
1413:Pseudounipolar
1410:
1405:
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1381:Basal dendrite
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1332:Axon terminals
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1184:Nerve fascicle
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913:Nervous tissue
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861:Photo of model
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1548:α motorneuron
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55:
54:neurofilament
51:
47:
41:
36:
31:
19:
1723:Back anatomy
1593:Gap junction
1515:Motor neuron
1309:Axon hillock
1285:nerve fibers
1239:Schwann cell
1149:
1132:
1120:
1110:
1028:Medium spiny
941:White matter
929:Tissue Types
878:at uwlax.edu
761:
757:
743:
710:
707:Neuroscience
706:
700:
667:
663:
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560:
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543:
526:
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506:. Retrieved
502:
492:
481:. Retrieved
477:
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401:
389:
376:
364:ion channels
361:
346:
328:neural crest
325:
313:
299:
291:
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271:
267:
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252:
248:
242:
210:
202:spinal nerve
185:
181:
177:
175:
129:A14.2.00.006
104:
88:Neural crest
1608:Active zone
1573:Termination
1423:Interneuron
1327:Telodendron
1235:Myelination
1217:Endoneurium
1212:Perineurium
1033:Interneuron
1023:Von Economo
971:Decussation
966:Nerve tract
936:Grey matter
758:J. Neurosci
478:Physiopedia
428:nociception
392:nociception
352:nociception
343:Nociception
332:neural tube
330:cells, not
322:Development
233:spinal cord
198:dorsal root
94:Identifiers
1717:Categories
1678:Nociceptor
1418:Multipolar
1367:Nissl body
1244:Neurilemma
1207:Epineurium
992:Cell Types
754:Receptors"
483:2021-05-15
474:"Ganglion"
461:References
227:(i.e. the
1693:Hair cell
1227:Neuroglia
1189:Funiculus
1078:Microglia
1051:Astrocyte
1008:Pyramidal
961:Lemniscus
523:Kandel ER
449:Knee jerk
420:receptors
408:receptors
239:Structure
219:. In the
217:afferents
83:Precursor
1478:Ia or Aα
1408:Unipolar
1357:Dendrite
1342:Axolemma
1337:Axoplasm
1121:Ganglion
1061:Tanycyte
1013:Purkinje
1000:Neuronal
983:Meninges
978:Neuropil
790:24920633
735:31565617
727:10579219
692:23961565
643:11850451
585:38351962
577:17720533
438:See also
422:but not
338:Function
310:Location
231:and the
194:ganglion
57:antibody
1620:Autapse
1581:Synapse
1428:Renshaw
1403:Bipolar
1280:Neurons
1133:Ventral
1104:General
1018:Granule
870:Diagram
781:6608243
684:8893432
634:6757581
278:in the
196:) in a
190:neurons
117:D005727
77:Details
1473:fibers
1111:Dorsal
788:
778:
733:
725:
690:
682:
641:
631:
583:
575:
535:
508:30 May
251:and a
46:embryo
1396:Types
1293:Parts
1162:White
1143:Ramus
1126:Ramus
1043:Glial
876:Photo
731:S2CID
688:S2CID
664:Spine
581:S2CID
553:(PDF)
262:, an
229:brain
213:axons
200:of a
164:[
100:Latin
1319:Axon
1301:Soma
1157:Gray
1138:Root
1116:Root
786:PMID
723:PMID
680:PMID
639:PMID
573:PMID
533:ISBN
510:2018
432:pain
430:and
416:GABA
404:GABA
211:The
180:(or
153:5888
141:6167
124:TA98
112:MeSH
1533:SVE
1528:GVE
1523:GSE
1468:SVA
1463:SSA
1458:GVA
1453:GSA
1096:PNS
921:CNS
863:at
776:PMC
766:doi
715:doi
672:doi
629:PMC
621:doi
565:doi
235:).
192:(a
148:FMA
136:TA2
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