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Epstein–Barr virus–encoded small RNAs

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hybridisation to the detection of Epstein-Barr Virus in clinical specimens in 1990. The abundance of EBER targets in cells with latent EBV infection cells and ease of non-isotopic methodology in formalin-fixed paraffin wax embedded tissue sections made EBER
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Similar to EBER1, EBER2 is very highly expressed in latently infected cells. Unlike EBER1, the sequence of EBER2 is less conserved in related herpesviruses (~50% conservation). However, the
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Yamamoto N, Takizawa T, Iwanaga Y, Shimizu N, Yamamoto N (November 2000). "Malignant transformation of B lymphoma cell line BJAB by Epstein-Barr virus-encoded small RNAs".
1156: 295:"Two small RNAs encoded by Epstein-Barr virus and complexed with protein are precipitated by antibodies from patients with systemic lupus erythematosus" 1438: 1433: 146:
are proposed. They have also been shown to be present in exosomes released from infected cells and could be involved in cell to cell interaction.
197: 403:"Epstein-Barr virus-infected cells release Fas ligand in exosomal fractions and induce apoptosis in recipient cells via the extrinsic pathway" 276:
hybridisation eminently suited to clinical practice. EBER detection has become an integral component of routine diagnostic histopathology.
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Wu, Tzyy-Choou; Mann, Risa B.; Charache, Patricia; Hayward, S. Diane; Staal, Steve; Lambe, Beverly C.; Ambinder, Richard F. (1990-11-15).
2018: 2013: 2008: 2003: 1965: 1960: 2340: 1998: 1993: 1469: 1464: 1459: 1183: 2721: 684:"The Epstein-Barr virus (EBV) small RNA EBER1 binds and relocalizes ribosomal protein L22 in EBV-infected human B lymphocytes" 2484: 921:"Epstein Barr virus (EBV) encoded small RNAs: targets for detection by in situ hybridisation with oligonucleotide probes" 878:
Barletta, Janet M.; Kingma, Douglas W.; Ling, Yun; Charache, Patricia; Mann, Risa B.; Ambinder, Richard F. (April 1993).
1296: 2454: 2388: 1615: 2082: 1750: 2865: 2601: 2075: 2070: 1176: 1074: 260:; however, it is believed that the other features of EBER2, particularly its two long and highly conserved 2855: 2703: 2638: 2310: 2286: 2093: 1978: 1884: 1810: 1735: 1630: 1514: 1449: 1369: 1335: 1286: 1379: 1306: 1271: 1072:
Weiss, Lawrence M; Chen, Yuan-Yuan (2013-01-01). "EBER in situ hybridization for Epstein-Barr virus".
635:"Multiple domains of EBER 1, an Epstein-Barr virus noncoding RNA, recruit human ribosomal protein L22" 2261: 2065: 1266: 2760: 2648: 2574: 2512: 2464: 2416: 2368: 2320: 2199: 2048: 1943: 1704: 1610: 1590: 1573: 1423: 1311: 1246: 170: 139: 252:
highly conserved (see Figure 1). EBER2 is only known to bind cellular proteins (specifically, the
2860: 1169: 2823: 2659: 2544: 1413: 1384: 127: 93: 978:"Presence of Epstein-Barr virus in Hodgkin's disease is not exclusive to Reed-Sternberg cells" 346:"Tracking EBV-encoded RNAs (EBERs) from the nucleus to the excreted exosomes of B-lymphocytes" 192:
changes, though this has never been found deleted in nature. EBER expression alone can induce
2793: 2684: 2564: 2436: 2296: 832: 209: 2595: 2533: 2220: 1664: 1655: 1577: 1524: 1345: 1236: 17: 735:"AUF1/hnRNP D is a novel protein partner of the EBER1 noncoding RNA of Epstein-Barr virus" 8: 2266: 1660: 1650: 1569: 543:"Oncogenic role of Epstein-Barr virus-encoded RNAs in Burkitt's lymphoma cell line Akata" 245: 2788: 2665: 1002: 860: 808: 783: 759: 734: 659: 634: 615: 518: 493: 378: 174: 953: 880:"Rapid in situ hybridization for the diagnosis of latent Epstein-Barr virus infection" 603: 567: 542: 321: 294: 2240: 1988: 1927: 1692: 1091: 1054: 1046: 1007: 989: 958: 940: 901: 852: 813: 764: 715: 710: 683: 664: 607: 572: 558: 523: 474: 430: 422: 383: 365: 326: 135: 100: 864: 619: 2502: 2108: 1845: 1840: 1835: 1830: 1825: 1820: 1799: 1083: 1038: 997: 948: 932: 891: 844: 803: 795: 754: 746: 705: 695: 654: 646: 599: 562: 554: 513: 505: 464: 414: 373: 357: 316: 306: 178: 88: 1161: 2732: 2189: 2179: 1932: 1087: 1042: 138:(RNP) complexes. Although a precise function for EBERs remains elusive, roles in 401:
Ahmed, Waqar; Philip, Pretty S.; Attoub, Samir; Khan, Gulfaraz (December 2015).
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Khan, G.; Coates, P. J.; Gupta, R. K.; Kangro, H. O.; Slavin, G. (April 1992).
833:"Detection of ebv gene expression in reed-sternberg cells of Hodgkin's disease" 688:
Proceedings of the National Academy of Sciences of the United States of America
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Proceedings of the National Academy of Sciences of the United States of America
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present in infected cells. EBERs interact with several host proteins to form
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Khan, G.; Coates, P. J.; Kangro, H. O.; Slavin, G. (July 1992).
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Komano J, Maruo S, Kurozumi K, Oda T, Takada K (December 1999).
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Lerner MR, Andrews NC, Miller G, Steitz JA (February 1981).
264:, may also serve as binding sites for yet unknown proteins. 2708: 2539: 2151: 2136: 1565: 1301: 1151: 1140: 1129: 1118: 225: 60: 877: 2769: 2765: 2748: 1894: 1745: 682:
Toczyski DP, Matera AG, Ward DC, Steitz JA (April 1994).
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Ahmed, Waqar; Tariq, Saeed; Khan, Gulfaraz (2018-10-18).
292: 131: 77: 1027:"Screening for Epstein-Barr virus in Hodgkin's lymphoma" 681: 632: 451:
Conrad NK, Fok V, Cazalla D, Borah S, Steitz JA (2006).
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Moss WN, Lee N, Pimienta G, Steitz JA (20 Dec 2013).
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Fok V, Mitton-Fry RM, Grech A, Steitz JA (May 2006).
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Cold Spring Harbor Symposia on Quantitative Biology
267:Richard Ambinder pioneered the application of EBER 732: 2847: 1157:Epstein–Barr virus stable intronic sequence RNAs 1115:Page for Human herpesvirus 1 small nucleolar RNA 733:Lee N, Pimienta G, Steitz JA (November 2012). 492:Moss WN, Lee N, Pimienta G, Steitz JA (2014). 343: 2805: 1177: 116:Epstein–Barr virus–encoded small RNAs (EBERs) 2474: 2426: 2378: 2330: 726: 184:EBERs 1 and 2 can be deleted from the viral 2814: 1640: 626: 1184: 1170: 775: 35: 2341:Parainfluenza hemagglutinin-neuraminidase 1071: 1001: 952: 895: 807: 758: 709: 699: 658: 566: 517: 468: 377: 320: 310: 212:and causes this protein to move from the 165:in length respectively, nuclear-enriched 235: 485: 446: 444: 240:Consensus secondary structure for EBER2 41:Conserved secondary structure of EBER1. 14: 2848: 2584: 2522: 1600: 1256: 256:) at its terminal stretch of repeated 2485:Respiratory syncytial virus G protein 1165: 2572: 2510: 2462: 2414: 2366: 2318: 1882: 1808: 1512: 1367: 1333: 1024: 784:"RNA families in Epstein-Barr virus" 494:"RNA families in Epstein-Barr virus" 441: 198:severe combined immunodeficient mice 24: 25: 2877: 2389:Mumps hemagglutinin-neuraminidase 1106: 982:The American Journal of Pathology 1751:Hepatitis B virus DNA polymerase 559:10.1128/JVI.73.12.9827-9831.1999 1582:(non-enveloped circular ds-DNA) 1065: 1018: 969: 912: 871: 837:International Journal of Cancer 824: 453:"The challenge of viral snRNPs" 407:The Journal of General Virology 675: 583: 534: 394: 337: 286: 13: 1: 2602:Vesiculovirus matrix proteins 925:Journal of Clinical Pathology 884:Molecular and Cellular Probes 604:10.1016/S0014-5793(00)02145-1 279: 149: 126:of human cells infected with 1088:10.1007/978-1-62703-357-2_16 1075:Methods in Molecular Biology 1043:10.1007/978-1-59745-447-6_13 1031:Methods in Molecular Biology 208:EBER1 associates with human 7: 2639:Structure and genome of HIV 1696:(circular partially ds-DNA) 10: 2882: 1272:Herpesvirus glycoprotein B 362:10.1038/s41598-018-33758-4 2782: 2719: 2646: 2637: 2628: 2563: 2501: 2453: 2405: 2357: 2309: 2284: 2251: 2209: 2197: 2188: 2173: 2091: 2046: 2031: 1976: 1941: 1926: 1911: 1858: 1793: 1780: 1771: 1733: 1702: 1691: 1628: 1588: 1559: 1541: 1503: 1478: 1447: 1421: 1412: 1401: 1358: 1324: 1284: 1267:HHV capsid portal protein 1244: 1235: 1217: 1208: 99: 87: 76: 71: 59: 51: 46: 34: 29: 231: 203: 2262:Influenza hemagglutinin 1025:Khan, Gulfaraz (2009). 470:10.1101/sqb.2006.71.057 161:are short, 167 and 172 2824:Gag-onc fusion protein 897:10.1006/mcpr.1993.1014 849:10.1002/ijc.2910460509 751:10.1261/rna.034900.112 701:10.1073/pnas.91.8.3463 241: 2794:murine leukemia virus 2685:Reverse transcriptase 2565:Indiana vesiculovirus 2437:Measles hemagglutinin 312:10.1073/pnas.78.2.805 239: 210:ribosomal protein L22 169:. These two RNAs are 1525:Early 35 kDa protein 937:10.1136/jcp.45.7.616 419:10.1099/jgv.0.000313 651:10.1261/rna.2339606 547:Journal of Virology 246:secondary structure 188:without noticeable 2866:Epstein–Barr virus 2856:Molecular genetics 2789:Rous sarcoma virus 1148:Page for IRES_EBNA 1137:Page for v-snoRNA1 350:Scientific Reports 242: 175:RNA polymerase III 128:Epstein–Barr virus 94:Epstein–Barr virus 2843: 2842: 2839: 2838: 2835: 2834: 2831: 2830: 2778: 2777: 2624: 2623: 2620: 2619: 2616: 2615: 2612: 2611: 2559: 2558: 2555: 2554: 2497: 2496: 2493: 2492: 2449: 2448: 2445: 2444: 2401: 2400: 2397: 2396: 2353: 2352: 2349: 2348: 2305: 2304: 2280: 2279: 2169: 2168: 2165: 2164: 2027: 2026: 1907: 1906: 1903: 1902: 1854: 1853: 1767: 1766: 1763: 1762: 1759: 1758: 1687: 1686: 1674: 1673: 1624: 1623: 1537: 1536: 1533: 1532: 1499: 1498: 1397: 1396: 1393: 1392: 1354: 1353: 1320: 1319: 1280: 1279: 800:10.4161/rna.27488 745:(11): 2073–2082. 553:(12): 9827–9831. 510:10.4161/rna.27488 413:(12): 3646–3659. 224:(A1, A2/B1 and D/ 136:ribonucleoprotein 122:localized in the 112: 111: 16:(Redirected from 2873: 2812: 2811: 2803: 2802: 2644: 2643: 2635: 2634: 2582: 2581: 2570: 2569: 2520: 2519: 2508: 2507: 2503:Zaire ebolavirus 2472: 2471: 2460: 2459: 2424: 2423: 2412: 2411: 2376: 2375: 2364: 2363: 2328: 2327: 2316: 2315: 2207: 2206: 2195: 2194: 2186: 2185: 2109:3C-like protease 2044: 2043: 1939: 1938: 1924: 1923: 1880: 1879: 1806: 1805: 1800:Duplornaviricota 1791: 1790: 1778: 1777: 1700: 1699: 1638: 1637: 1598: 1597: 1586: 1585: 1557: 1556: 1510: 1509: 1419: 1418: 1410: 1409: 1365: 1364: 1331: 1330: 1254: 1253: 1242: 1241: 1233: 1232: 1215: 1214: 1186: 1179: 1172: 1163: 1162: 1100: 1099: 1069: 1063: 1062: 1022: 1016: 1015: 1005: 973: 967: 966: 956: 916: 910: 909: 899: 875: 869: 868: 828: 822: 821: 811: 779: 773: 772: 762: 730: 724: 723: 713: 703: 694:(8): 3463–3467. 679: 673: 672: 662: 630: 624: 623: 587: 581: 580: 570: 538: 532: 531: 521: 489: 483: 482: 472: 448: 439: 438: 398: 392: 391: 381: 341: 335: 334: 324: 314: 290: 179:latent infection 39: 27: 26: 21: 2881: 2880: 2876: 2875: 2874: 2872: 2871: 2870: 2846: 2845: 2844: 2827: 2774: 2733:transactivators 2715: 2608: 2551: 2489: 2441: 2393: 2345: 2301: 2276: 2247: 2190:Influenza virus 2180:Negarnaviricota 2177: 2175: 2161: 2087: 2035: 2023: 1972: 1933:Kitrinoviricota 1930: 1915: 1913: 1899: 1871: 1850: 1797: 1782: 1755: 1729: 1695: 1683: 1670: 1620: 1581: 1563: 1549: 1543: 1529: 1495: 1474: 1443: 1405: 1404:(Duplodnaviria, 1403: 1402:circular ds-DNA 1389: 1350: 1316: 1276: 1225: 1219: 1204: 1190: 1109: 1104: 1103: 1070: 1066: 1023: 1019: 974: 970: 917: 913: 876: 872: 829: 825: 780: 776: 731: 727: 680: 676: 631: 627: 588: 584: 539: 535: 490: 486: 449: 442: 399: 395: 342: 338: 291: 287: 282: 234: 206: 167:non-coding RNAs 152: 120:non-coding RNAs 42: 23: 22: 15: 12: 11: 5: 2879: 2869: 2868: 2863: 2861:Non-coding RNA 2858: 2841: 2840: 2837: 2836: 2833: 2832: 2829: 2828: 2826: 2821: 2819: 2809: 2807:Fusion protein 2800: 2799: 2798: 2797: 2796: 2791: 2780: 2779: 2776: 2775: 2773: 2772: 2763: 2758: 2753: 2752: 2751: 2746: 2741: 2728: 2726: 2717: 2716: 2714: 2713: 2712: 2711: 2706: 2694: 2693: 2692: 2690:HIV-1 protease 2687: 2682: 2670: 2669: 2668: 2655: 2653: 2641: 2632: 2626: 2625: 2622: 2621: 2618: 2617: 2614: 2613: 2610: 2609: 2607: 2606: 2605: 2604: 2596:matrix protein 2591: 2589: 2579: 2567: 2561: 2560: 2557: 2556: 2553: 2552: 2550: 2549: 2548: 2547: 2542: 2534:matrix protein 2529: 2527: 2517: 2505: 2499: 2498: 2495: 2494: 2491: 2490: 2488: 2487: 2481: 2479: 2469: 2457: 2451: 2450: 2447: 2446: 2443: 2442: 2440: 2439: 2433: 2431: 2421: 2409: 2403: 2402: 2399: 2398: 2395: 2394: 2392: 2391: 2385: 2383: 2373: 2361: 2355: 2354: 2351: 2350: 2347: 2346: 2344: 2343: 2337: 2335: 2325: 2313: 2307: 2306: 2303: 2302: 2300: 2299: 2293: 2291: 2282: 2281: 2278: 2277: 2275: 2274: 2269: 2264: 2258: 2256: 2249: 2248: 2246: 2245: 2244: 2243: 2235:viral envelope 2231: 2230: 2229: 2221:matrix protein 2216: 2214: 2204: 2192: 2183: 2176:negative-sense 2171: 2170: 2167: 2166: 2163: 2162: 2160: 2159: 2154: 2149: 2144: 2139: 2134: 2129: 2124: 2119: 2114: 2113: 2112: 2100: 2098: 2089: 2088: 2086: 2085: 2080: 2079: 2078: 2073: 2068: 2060:viral envelope 2055: 2053: 2041: 2029: 2028: 2025: 2024: 2022: 2021: 2016: 2011: 2006: 2001: 1996: 1991: 1985: 1983: 1974: 1973: 1971: 1970: 1969: 1968: 1963: 1955:viral envelope 1950: 1948: 1936: 1921: 1914:positive-sense 1909: 1908: 1905: 1904: 1901: 1900: 1898: 1897: 1891: 1889: 1877: 1856: 1855: 1852: 1851: 1849: 1848: 1843: 1838: 1833: 1828: 1823: 1817: 1815: 1803: 1788: 1775: 1769: 1768: 1765: 1764: 1761: 1760: 1757: 1756: 1754: 1753: 1748: 1742: 1740: 1731: 1730: 1728: 1727: 1726: 1716: 1711: 1709: 1697: 1689: 1688: 1685: 1684: 1682: 1681: 1675: 1672: 1671: 1669: 1668: 1658: 1653: 1647: 1645: 1635: 1626: 1625: 1622: 1621: 1619: 1618: 1613: 1607: 1605: 1595: 1583: 1561:Polyomaviridae 1554: 1539: 1538: 1535: 1534: 1531: 1530: 1528: 1527: 1521: 1519: 1507: 1501: 1500: 1497: 1496: 1494: 1493: 1487: 1485: 1476: 1475: 1473: 1472: 1467: 1462: 1456: 1454: 1445: 1444: 1442: 1441: 1436: 1430: 1428: 1416: 1407: 1406:Varidnaviria?) 1399: 1398: 1395: 1394: 1391: 1390: 1388: 1387: 1382: 1376: 1374: 1362: 1356: 1355: 1352: 1351: 1349: 1348: 1342: 1340: 1328: 1322: 1321: 1318: 1317: 1315: 1314: 1309: 1304: 1299: 1293: 1291: 1282: 1281: 1278: 1277: 1275: 1274: 1269: 1263: 1261: 1251: 1239: 1237:Herpes simplex 1230: 1212: 1206: 1205: 1193:Viral proteins 1189: 1188: 1181: 1174: 1166: 1160: 1159: 1154: 1145: 1143: 1134: 1132: 1126:Page for EBER1 1123: 1121: 1112: 1108: 1107:External links 1105: 1102: 1101: 1064: 1017: 988:(4): 757–762. 968: 931:(7): 616–620. 911: 890:(2): 105–109. 870: 843:(5): 801–804. 823: 774: 725: 674: 645:(5): 872–882. 625: 598:(2): 153–158. 582: 533: 484: 440: 393: 336: 305:(2): 805–809. 284: 283: 281: 278: 233: 230: 205: 202: 173:by the host's 151: 148: 140:transformation 110: 109: 104: 97: 96: 91: 85: 84: 81: 74: 73: 69: 68: 63: 57: 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2342: 2339: 2338: 2336: 2333: 2329: 2326: 2324: 2322: 2317: 2314: 2312: 2311:Parainfluenza 2308: 2298: 2295: 2294: 2292: 2290: 2288: 2283: 2273: 2270: 2268: 2267:Neuraminidase 2265: 2263: 2260: 2259: 2257: 2254: 2250: 2242: 2239: 2238: 2237: 2236: 2232: 2228: 2225: 2224: 2223: 2222: 2218: 2217: 2215: 2212: 2208: 2205: 2203: 2201: 2196: 2193: 2191: 2187: 2184: 2181: 2172: 2158: 2155: 2153: 2150: 2148: 2145: 2143: 2140: 2138: 2135: 2133: 2130: 2128: 2125: 2123: 2120: 2118: 2115: 2110: 2107: 2106: 2105: 2102: 2101: 2099: 2097: 2095: 2090: 2084: 2081: 2077: 2074: 2072: 2069: 2067: 2064: 2063: 2062: 2061: 2057: 2056: 2054: 2052: 2050: 2045: 2042: 2039: 2034: 2030: 2020: 2017: 2015: 2012: 2010: 2007: 2005: 2002: 2000: 1997: 1995: 1992: 1990: 1987: 1986: 1984: 1982: 1980: 1975: 1967: 1964: 1962: 1959: 1958: 1957: 1956: 1952: 1951: 1949: 1947: 1945: 1940: 1937: 1934: 1929: 1925: 1922: 1919: 1910: 1896: 1893: 1892: 1890: 1888: 1886: 1881: 1878: 1875: 1869: 1865: 1861: 1857: 1847: 1844: 1842: 1839: 1837: 1834: 1832: 1829: 1827: 1824: 1822: 1819: 1818: 1816: 1814: 1812: 1807: 1804: 1801: 1796: 1792: 1789: 1786: 1779: 1776: 1774: 1770: 1752: 1749: 1747: 1744: 1743: 1741: 1739: 1737: 1732: 1725: 1722: 1721: 1720: 1717: 1715: 1712: 1710: 1708: 1706: 1701: 1698: 1694: 1690: 1680: 1677: 1676: 1666: 1662: 1659: 1657: 1654: 1652: 1649: 1648: 1646: 1643: 1639: 1636: 1634: 1632: 1627: 1617: 1614: 1612: 1609: 1608: 1606: 1603: 1599: 1596: 1594: 1592: 1587: 1584: 1579: 1575: 1571: 1567: 1562: 1558: 1555: 1552: 1547: 1540: 1526: 1523: 1522: 1520: 1518: 1516: 1511: 1508: 1506: 1505:Baculoviridae 1502: 1492: 1489: 1488: 1486: 1484: 1482: 1477: 1471: 1468: 1466: 1463: 1461: 1458: 1457: 1455: 1453: 1451: 1446: 1440: 1437: 1435: 1432: 1431: 1429: 1427: 1425: 1420: 1417: 1415: 1411: 1408: 1400: 1386: 1383: 1381: 1378: 1377: 1375: 1373: 1371: 1366: 1363: 1361: 1357: 1347: 1344: 1343: 1341: 1339: 1337: 1332: 1329: 1327: 1323: 1313: 1310: 1308: 1305: 1303: 1300: 1298: 1295: 1294: 1292: 1290: 1288: 1283: 1273: 1270: 1268: 1265: 1264: 1262: 1259: 1255: 1252: 1250: 1248: 1243: 1240: 1238: 1234: 1231: 1228: 1223: 1222:Duplodnaviria 1218:linear ds-DNA 1216: 1213: 1211: 1207: 1202: 1198: 1194: 1187: 1182: 1180: 1175: 1173: 1168: 1167: 1164: 1158: 1155: 1153: 1149: 1146: 1144: 1142: 1138: 1135: 1133: 1131: 1127: 1124: 1122: 1120: 1116: 1113: 1111: 1110: 1097: 1093: 1089: 1085: 1081: 1077: 1076: 1068: 1060: 1056: 1052: 1048: 1044: 1040: 1036: 1032: 1028: 1021: 1013: 1009: 1004: 999: 995: 991: 987: 983: 979: 972: 964: 960: 955: 950: 946: 942: 938: 934: 930: 926: 922: 915: 907: 903: 898: 893: 889: 885: 881: 874: 866: 862: 858: 854: 850: 846: 842: 838: 834: 827: 819: 815: 810: 805: 801: 797: 793: 789: 785: 778: 770: 766: 761: 756: 752: 748: 744: 740: 736: 729: 721: 717: 712: 707: 702: 697: 693: 689: 685: 678: 670: 666: 661: 656: 652: 648: 644: 640: 636: 629: 621: 617: 613: 609: 605: 601: 597: 593: 586: 578: 574: 569: 564: 560: 556: 552: 548: 544: 537: 529: 525: 520: 515: 511: 507: 503: 499: 495: 488: 480: 476: 471: 466: 462: 458: 454: 447: 445: 436: 432: 428: 424: 420: 416: 412: 408: 404: 397: 389: 385: 380: 375: 371: 367: 363: 359: 355: 351: 347: 340: 332: 328: 323: 318: 313: 308: 304: 300: 296: 289: 285: 277: 275: 270: 265: 263: 259: 255: 251: 247: 238: 229: 227: 223: 219: 215: 211: 201: 199: 195: 191: 187: 182: 180: 176: 172: 168: 164: 160: 156: 147: 145: 141: 137: 133: 129: 125: 121: 117: 108: 105: 102: 98: 95: 92: 90: 86: 82: 79: 75: 70: 67: 64: 62: 58: 54: 50: 45: 38: 33: 28: 19: 2731: 2720: 2696: 2672: 2658: 2647: 2594: 2573: 2532: 2511: 2476:glycoprotein 2463: 2428:glycoprotein 2415: 2380:glycoprotein 2367: 2332:glycoprotein 2319: 2285: 2253:glycoprotein 2233: 2219: 2198: 2092: 2083:Nucleocapsid 2058: 2047: 2038:Pisuviricota 1977: 1953: 1942: 1883: 1874:Pisuviricota 1809: 1734: 1703: 1629: 1589: 1551:Monodnaviria 1513: 1490: 1479: 1448: 1422: 1414:Epstein–Barr 1368: 1360:Adenoviridae 1334: 1285: 1245: 1227:Varidnaviria 1079: 1073: 1067: 1034: 1030: 1020: 985: 981: 971: 928: 924: 914: 887: 883: 873: 840: 836: 826: 794:(1): 10–17. 791: 787: 777: 742: 738: 728: 691: 687: 677: 642: 638: 628: 595: 592:FEBS Letters 591: 585: 550: 546: 536: 504:(1): 10–17. 501: 497: 487: 460: 456: 410: 406: 396: 356:(1): 15438. 353: 349: 339: 302: 298: 288: 273: 268: 266: 249: 243: 207: 183: 158: 154: 153: 115: 113: 2816:oncoprotein 1928:Hepatitis C 1693:Hepatitis B 1679:Agnoprotein 1642:oncoprotein 1616:VP2 and VP3 1037:: 311–322. 788:RNA Biology 498:RNA Biology 463:: 377–384. 218:nucleoplasm 171:transcribed 163:nucleotides 144:oncogenesis 47:Identifiers 2850:Categories 2241:M2 protein 2227:M1 protein 2033:SARS-CoV-2 1082:: 223–30. 280:References 262:stem-loops 190:phenotypic 150:Background 118:are small 103:structures 72:Other data 2783:Multiple 2680:Integrase 1918:Riboviria 1795:Rotavirus 1785:Riboviria 1546:Riboviria 1051:1064-3745 994:0002-9440 945:0021-9746 427:1465-2099 370:2045-2322 254:La domain 248:of EBER2 214:nucleolus 89:Domain(s) 2076:Membrane 2071:Envelope 1665:SV40 Tag 1326:Vaccinia 1096:23666702 1059:19347303 865:22788289 818:24441309 769:23012480 669:16556938 620:35288002 612:11068051 577:10559294 528:24441309 479:17381320 435:26467838 388:30337610 258:uridines 181:of EBV. 2407:Measles 1860:Rhinov. 1307:ICP34.5 1012:1314022 1003:1886366 963:1325480 906:8391639 857:2172169 809:3929418 760:3479396 720:8159770 660:1440895 519:3929418 379:6193935 331:6262773 274:in situ 269:in situ 216:to the 194:tumours 177:during 124:nucleus 66:RF01789 2586:capsid 2524:capsid 2272:HA-tag 2211:capsid 2174:ss-RNA 2104:ORF1ab 1912:ss-RNA 1872:etc. ( 1781:ds-RNA 1602:capsid 1470:EBNA-3 1465:EBNA-2 1460:EBNA-1 1258:capsid 1094:  1057:  1049:  1010:  1000:  992:  961:  954:495191 951:  943:  904:  863:  855:  816:  806:  767:  757:  718:  708:  667:  657:  618:  610:  575:  568:113031 565:  526:  516:  477:  433:  425:  386:  376:  368:  329:  322:319891 319:  222:hnRNPs 186:genome 52:Symbol 2722:VRAPs 2704:gp120 2359:Mumps 2157:ORF9b 2147:ORF7b 2142:ORF7a 2132:ORF3d 2127:ORF3c 2122:ORF3b 2117:ORF3a 2111:(NS5) 2066:Spike 1868:Hep A 1864:Polio 1724:HBeAg 1719:HBcAg 1714:HBsAg 1578:HaPyV 1574:MCPyV 1542:other 1481:ncRNA 1439:LMP-2 1434:LMP-1 1312:ICP47 1297:vmw65 1197:early 861:S2CID 711:43597 616:S2CID 232:EBER2 204:EBER1 159:EBER2 155:EBER1 55:EBER1 30:EBER1 2709:gp41 2649:VSPs 2575:VSPs 2545:VP24 2540:VP40 2513:VSPs 2465:VSPs 2417:VSPs 2369:VSPs 2321:VSPs 2287:VNPs 2200:VSPs 2152:ORF8 2137:ORF6 2094:VNPs 2049:VSPs 2019:NS5B 2014:NS5A 2009:NS4B 2004:NS4A 1979:VNPs 1944:VSPs 1885:VNPs 1846:NSP6 1841:NSP5 1836:NSP4 1831:NSP3 1826:NSP2 1821:NSP1 1811:VNPs 1736:VNPs 1705:VSPs 1661:LTag 1656:MTag 1651:STag 1631:VNPs 1591:VSPs 1570:MPyV 1566:SV40 1515:VNPs 1491:EBER 1450:VNPs 1424:VSPs 1370:VNPs 1346:B13R 1336:VNPs 1302:ICP8 1287:VNPs 1247:VSPs 1201:late 1199:and 1152:Rfam 1141:Rfam 1130:Rfam 1119:Rfam 1092:PMID 1055:PMID 1047:ISSN 1008:PMID 990:ISSN 959:PMID 941:ISSN 902:PMID 853:PMID 814:PMID 765:PMID 716:PMID 665:PMID 608:PMID 573:PMID 524:PMID 475:PMID 431:PMID 423:ISSN 384:PMID 366:ISSN 327:PMID 226:AUF1 157:and 142:and 132:RNAs 114:The 107:PDBe 83:Gene 80:type 61:Rfam 18:EBER 2770:Vpx 2768:or 2766:Vpu 2761:Vif 2756:Nef 2749:Vpr 2744:Rev 2739:Tat 2698:env 2674:pol 2666:p24 2660:gag 2455:RSV 2297:NS1 1999:NS3 1994:NS2 1895:VPg 1773:RNA 1746:HBx 1611:VP1 1385:E1B 1380:E1A 1210:DNA 1150:at 1139:at 1128:at 1117:at 1084:doi 1080:999 1039:doi 1035:511 998:PMC 986:140 949:PMC 933:doi 892:doi 845:doi 804:PMC 796:doi 755:PMC 747:doi 739:RNA 706:PMC 696:doi 655:PMC 647:doi 639:RNA 600:doi 596:484 563:PMC 555:doi 514:PMC 506:doi 465:doi 415:doi 374:PMC 358:doi 317:PMC 307:doi 228:). 196:in 101:PDB 78:RNA 2852:: 2630:RT 1989:P7 1966:E2 1961:E1 1866:, 1862:, 1576:, 1572:, 1568:, 1090:. 1078:. 1053:. 1045:. 1033:. 1029:. 1006:. 996:. 984:. 980:. 957:. 947:. 939:. 929:45 927:. 923:. 900:. 886:. 882:. 859:. 851:. 841:46 839:. 835:. 812:. 802:. 792:11 790:. 786:. 763:. 753:. 743:18 741:. 737:. 714:. 704:. 692:91 690:. 686:. 663:. 653:. 643:12 641:. 637:. 614:. 606:. 594:. 571:. 561:. 551:73 549:. 545:. 522:. 512:. 502:11 500:. 496:. 473:. 461:71 459:. 455:. 443:^ 429:. 421:. 411:96 409:. 405:. 382:. 372:. 364:. 352:. 348:. 325:. 315:. 303:78 301:. 297:. 250:is 200:. 2818:: 2724:: 2651:: 2588:: 2577:: 2526:: 2515:: 2478:: 2467:: 2430:: 2419:: 2382:: 2371:: 2334:: 2323:: 2289:: 2255:: 2213:: 2202:: 2182:) 2178:( 2096:: 2051:: 2040:) 2036:( 1981:: 1946:: 1935:) 1931:( 1920:) 1916:( 1887:: 1876:) 1870:, 1813:: 1802:) 1798:( 1787:) 1783:( 1738:: 1707:: 1667:) 1663:( 1644:: 1633:: 1604:: 1593:: 1580:) 1564:( 1553:) 1548:, 1544:( 1517:: 1483:: 1452:: 1426:: 1372:: 1338:: 1289:: 1260:: 1249:: 1229:) 1224:, 1220:( 1203:) 1195:( 1185:e 1178:t 1171:v 1098:. 1086:: 1061:. 1041:: 1014:. 965:. 935:: 908:. 894:: 888:7 867:. 847:: 820:. 798:: 771:. 749:: 722:. 698:: 671:. 649:: 622:. 602:: 579:. 557:: 530:. 508:: 481:. 467:: 437:. 417:: 390:. 360:: 354:8 333:. 309:: 20:)

Index

EBER

Rfam
RF01789
RNA
Domain(s)
Epstein–Barr virus
PDB
PDBe
non-coding RNAs
nucleus
Epstein–Barr virus
RNAs
ribonucleoprotein
transformation
oncogenesis
nucleotides
non-coding RNAs
transcribed
RNA polymerase III
latent infection
genome
phenotypic
tumours
severe combined immunodeficient mice
ribosomal protein L22
nucleolus
nucleoplasm
hnRNPs
AUF1

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