223:
28:
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349:), now considered "a flagship in Mexico's ethnobotanical research". He was able to attract significant synthetic organic chemists as researchers and instructors and to obtain funding to expand programs for the training of organic chemists. He and his colleagues regularly worked at Syntex during the day and then spent the evenings teaching chemistry. Rosenkranz also helped to start the
378:
Several prominent groups of international scientists were attempting to be the first to synthesize cortisone. Rosenkranz's team started working in two shifts, and their dedication paid off. In 1951, Rosenkranz, Djerassi, and their fellow researchers submitted a paper on the synthesis of cortisone, edging out reports from
Harvard and Merck by a matter of weeks.
457:
Rosenkranz understood the importance of peer recognition, not just commercial success, to the scientists who worked for him. He has said, "To have people work productively, you have to build an intellectually challenging environment, allow creative freedom, and insure peer recognition and respect for
397:
Having successfully synthesized cortisone, the researchers at Syntex continued to work on the synthesis of progesterone. A female sex hormone, progesterone was used to help pregnant women avoid miscarriages, and to treat infertility. Five months later, under the direction of
Rosenkranz and Djerassi,
372:
was critical to Syntex's first big success. Miramontes, George
Rosenkranz and Djerassi synthesis of norethindrone, later proven to be an effective pregnancy inhibitor, led to an infusion of capital in Syntex and Mexican steroid pharma industry. The Mayo clinic had reported that the steroid hormone
377:
was an effective anti-inflammatory, capable of relieving painful rheumatoid arthritis symptoms. However, as described by
Djerassi, "Until 1951, the only source of cortisone was through an extraordinarily complex process of 36 different chemical transformations starting from animal bile acids."
623:
and the
District of Columbia police captured Wright and Moss, and she was returned safely. The ransom money was later recovered and the two kidnappers were later convicted and sentenced, as was a third defendant, Orland D. Tolden. Wright was released in 1999, Moss in 1994, and Tolden in 1989.
178:
and numerous other useful steroids. Under
Rosenkranz's leadership, Syntex became "a powerful international force in the development of steroidal pharmaceuticals", and "a pioneer of biotechnology" in the San Francisco Bay Area. Rosenkranz stepped down as CEO in 1982, at the age of 65.
458:
the individual." A cascade of papers on steroid chemistry issued from the
Rosenkranz lab during the 1940s and 1950s. Rosenkranz himself is the author or co-author of over 300 articles in steroid chemistry and is named on over 150 patents.
1438:
1530:
279:
colleagues, but their presence put their mentor at risk. "We got together and we decided to leave
Switzerland to protect him," Rosenkranz said in a 2002 article for the Pan American Health Organization's magazine.
402:(norethindrone) was successfully completed by Miramontes, and Syntex applied for a patent, which was granted as US patent 2,744,122 on May 1, 1956. Syntex initially reached an agreement with the American company
344:
When he couldn't find enough fully trained local chemists, Rosenkranz recruited researchers from Mexico and around the world. Rosenkranz also helped to create an institute of chemistry, the
Instituto de QuĂmica
1208:
461:
Rosenkranz gave up his executive positions at Syntex in 1981. Although technically retired for over three decades, Rosenkranz was still active in the industry. In 1996, he became a member of the board of
619:
In July 1984, Rosenkranz' wife Edith was kidnapped at the summer North
American Bridge Championships in Washington, D.C., by Glenn I. Wright and Dennis Moss, and ransomed for one million dollars. The
1130:
410:
for the treatment of gynecological disorders, which was approved by the FDA in 1957. Parke-Davis however refused to develop Syntex's norethisterone as a contraceptive over concerns about a possible
475:
341:
Marker's chemical production processes. He didn't have much help: his initial staff included nine lab assistants and only one other chemist, and Mexico lacked a PhD program in chemistry.
1287:
350:
537:
306:
The important role of hormones in human health was already known, but ways to synthesize them were unknown. George Rosenkranz's skills as a chemist attracted the interest of
544:
1953:"Digital Gene Technologies names Dr. George Rosenkranz to board of directors; former chairman, president and CEO of Syntex Corp. to assist in corporate development efforts"
463:
1220:
2412:
1266:"American Chemical Society International Historic Chemical Landmarks. The "Marker Degradation" and Creation of the Mexican Steroid Hormone Industry 1938–1945"
1127:
1600:
311:
334:. After a disagreement Marker left, taking his steroid knowledge with him. Rosenkranz was recruited to replace him, and moved to Mexico City in 1945.
1768:
1386:
147:, who used native Mexican plant sources as raw materials. He was born in Hungary, studied in Switzerland and emigrated to the Americas to escape the
170:. Revolutionary advances in the understanding of steroid drugs and their production occurred under Dr Rosenkranz's direction. Syntex synthesized a
299:'s offer allowing refugees to stay in the country and work. He found work at the Vieta Plasencia Lab, where he was asked to develop treatments for
259:
Rosenkranz was born in 1916 in Budapest, Hungary, the son of Etel (Weiner) and Bertalan Rosenkranz. Rosenkranz studied chemical engineering at the
1926:
186:, in recognition of his significant contributions to the development of biotechnology through discovery, innovation, and public understanding. He
158:
corporation in Mexico City, Rosenkranz assembled a research group of organic chemists that included future leaders from around the world, such as
872:
1952:
307:
2213:
1295:
2437:
2193:
2079:
925:
The four Godfrey books combine fictional narrative and instructional bridge. The second, and first with co-author credit to Phillip Alder,
390:
1365:
1240:
2336:
2462:
2457:
2422:
1265:
567:
Rosenkranz was a world-class bridge player and one of the most successful in Mexico. He won 12 NABC-level events at thrice-annual
346:
2452:
2447:
1823:
988:
Rosenkranz se nacionalizó mexicano, siguió trabajando en Syntex por muchos años, actualmente vive en México y tiene 98 años.
572:
2106:
1906:
706:
667:
568:
513:
1886:
1856:
1748:
1568:
295:. The United States immediately entered World War II. Unable to go to Ecuador, Rosenkranz accepted the Cuban president
2119:
1475:
1109:
1012:
2417:
1584:
1420:
175:
107:
1814:
Tyrer, Louise (2011). "Introduction of the Pill and Its Impact". In Schneider, Dona; Lilienfeld, David E. (eds.).
2111:
759:
744:
620:
194:
414:
boycott of its other products. This delay placed Syntex at a disadvantage, but by 1962, they had partnered with
2313:
1611:
1531:"Scientist George Rosenkranz; Innovate: His determination helped millions ease their pain, plan their families"
2427:
2397:
2467:
2392:
1535:
1216:
527:
517:
509:
183:
33:
2387:
1394:
480:
466:
He was also president of the advisory board of ICT Mexicana. He died at the age of 102 on 23 June 2019.
2432:
2007:
797:
778:
1764:
1031:
235:
2402:
2382:
2274:
2260:
1983:
1445:
1349:
251:
1431:
143:; 20 August 1916 – 23 June 2019) was a pioneering Hungarian-born Mexican scientist in the field of
2076:
596:
2442:
2329:
2317:
2255:
2190:
2087:
1344:
222:
485:
447:
434:
100 ÎĽg). In March 1964, the FDA also approved Parke-Davis's version of the German company
337:
Rosenkranz faced the challenge of analyzing Marker's samples to identify their ingredients and
331:
1978:
1832:
1738:
929:"brings the Romex system to life through lively anecdotes instruction and quizzes". The last,
271:, began Rosenkranz's interest in steroid research. However, Nazi sympathizers were active in
2144:
1846:
1558:
1128:
USA Science & Engineering Festival – Role Models in Science & Engineering Achievement
1099:
268:
27:
2282:
1876:
1063:
2377:
2372:
2325:
1649:
576:
523:
415:
264:
78:
2269:
1638:"Cortical Hormones from alloSteroids: Synthesis of Cortisone from Reichstein's Compound D"
1560:
Jungle laboratories : Mexican peasants, national projects, and the making of the Pill
422:, which used Syntex's norethisterone. In March 1964, the FDA approved Syntex's version of
8:
2350:
2165:
969:
592:
559:
531:
369:
338:
167:
1653:
1719:
599:. In addition, he has made significant contributions to bidding theory. He created the
491:
386:
365:
163:
2036:
1816:
Public Health: The Development of a Discipline, Volume 2, Twentieth-Century Challenges
1798:
2340:
2287:
Perspectives in Health Magazine: The Magazine of the Pan American Health Organization
2233:
2125:
2115:
1882:
1852:
1819:
1802:
1744:
1711:
1706:
1689:
1667:
1564:
1471:
1175:
1105:
1068:
Perspectives in Health Magazine: The Magazine of the Pan American Health Organization
1008:
946:
633:
608:
604:
588:
296:
1032:"Scientists You Must Know: Pioneering steroid researcher George Rosenkranzh (Video)"
591:. In world championship teams competition, he represented Mexico in the quadrennial
2229:
2217:
1794:
1723:
1701:
1657:
1170:
1160:
822:
451:
300:
198:
792:
773:
2407:
2197:
2083:
1165:
1134:
851:
Everything You Always Wanted to Know About Trump Leads and Were Not Afraid to Ask
411:
1585:
https://www.nytimes.com/2019/06/23/obituaries/george-rosenkranz-dies-at-102.html
1492:
945:(Philadelphia: Science History Consultants, 2011), with editor Arnold Thackray,
838:
399:
319:
99:
1927:"Dr. George Rosenkranz Calls for Increased Commitment to Science and Research"
1878:
The estrogen elixir : a history of hormone replacement therapy in America
2366:
2101:
889:
580:
381:
361:
159:
2129:
1635:
236:“Scientists You Must Know: Pioneering steroid researcher George Rosenkranzh”
2059:
1806:
1671:
1148:
600:
584:
323:
292:
2270:
Scientists You Must Know: Pioneering steroid researcher George Rosenkranzh
1715:
974:
950:
1785:
Tyrer, Louise (January 1999). "Introduction of the Pill and Its Impact".
435:
403:
318:
in Mexico City, Mexico. They had formed the company in 1944 to work with
187:
2356:
1583:
George Rosenkranz, 102, a Developer of the Birth Control Pill, Is Dead:
1421:"George Rosenkranz, a Developer of the Birth Control Pill, Dies at 102"
913:
Godfrey's Stairway To The Stars: a step-by-step guide to modern bidding
260:
1636:
Rosenkranz, G.; Djerassi, Carl; Yashin, R.; Pataki, J. (7 July 1951).
1439:"Marker Degradation: Creation of the Mexican Steroid Hormone Industry"
611:
and Rosenkranz redouble, and wrote more than a dozen books on bridge.
1662:
1637:
431:
374:
354:
327:
171:
124:
103:
2346:
1818:. New Brunswick, N.J.: Rutgers University Press. pp. 277–287.
59:
1149:"A few comments on the development of organic chemistry in Mexico"
330:-containing Mexican yams, which would eventually give rise to the
2177:
495:
144:
37:
1209:"George Rosenkranz to Receive 2013 Biotechnology Heritage Award"
322:, a Penn State professor, and sought to synthesize the hormone
315:
288:
272:
155:
943:
George and Edith Rosenkranz: a memoir of their lives and times
540:, Mexican highest award for contributions to the health field.
284:
247:
148:
1317:
Raber, Linda (25 October 1999). "Steroid Industry Honored".
1104:. Sausalito, Calif.: University Science Books. p. 72.
595:
three times from 1972 to 1996 and the United States in the
1366:"Honoring The 100th Birthday of George Rosenkranz, PH.D."
813:
The Romex System of Bidding: a dynamic approach to bridge
276:
201:, with more than 13,000 masterpoints and 12 NABC titles (
2273:, Video, from the Scientists You Must Know Film Series,
1393:. American Contract Bridge League (ACBL). Archived from
1123:
1121:
283:
RuĹľiÄŤka arranged an academic position for Rosenkranz in
1026:
1024:
970:"La pĂldora anticonceptiva, Âżes de 'padres' mexicanos?"
2099:
1743:. Princeton: Princeton University Press. p. 409.
1690:"Steroid research at Syntex: "the pill" and cortisone"
418:'s Ortho division to introduce the birth control pill
205:). He wrote or co-wrote more than 10 books on bridge.
1907:"3 new oral contraceptives approved for sale in U.S."
1288:"Steroid pioneer gets Heritage Foundation, BIO award"
1118:
291:, Cuba, for a ship to Ecuador, the Japanese attacked
1021:
2253:
1342:
933:incorporates 1998–2001 improvements in the system.
547:, Mexican National Prize in Pharmaceutical Sciences
1737:Padgett, John F.; Powell, Walter W., eds. (2012).
1466:Sismondo, Sergio; Greene, Jeremy A. (2015-05-11).
1418:
847:(Devyn, 1985) – Championship bridge series, no. 33
248:“BIO 2013 Award Presentation to George Rosenkranz”
1851:. New York: Oxford University Press. p. 79.
1338:
1336:
1334:
1332:
656:
550:Leadership Award of the Mexican Health Federation
2364:
1848:Triumph of the heart : the story of statins
614:
1921:
1919:
1280:
1101:The golden helix : inside biotech ventures
831:(New York state: Barclay Bridge Supplies, 1978)
2090:(worldbridge.org). Retrieved 18 December 2014.
1563:. Durham : Duke University Press. p. 61.
1465:
1329:
1057:
1055:
1053:
1051:
1049:
694:Vanderbilt Knockout Teams (3) 1975, 1976, 1982
2413:Businesspeople in the pharmaceutical industry
2029:
1736:
1598:
2326:"Master Points record for George Rosenkranz"
2314:"International record for George Rosenkranz"
1916:
869:Our Man Godfrey: tales from the bridge table
736:Reisinger Board-a-Match Teams (2) 1980, 1997
1683:
1681:
1046:
819:Win with Romex: the key to accurate bidding
287:, Ecuador. While Rosenkranz was waiting in
2136:
1870:
1868:
1740:The emergence of organizations and markets
1594:
1592:
1524:
1522:
1520:
1518:
1516:
1490:
1203:
1201:
1199:
1197:
1195:
1193:
1093:
1091:
1089:
26:
2142:
1705:
1661:
1484:
1258:
1174:
1164:
469:
197:(ACBL) Grand Life Master at his hobby of
1881:. Baltimore: Johns Hopkins Univ. Press.
1780:
1778:
1687:
1678:
1629:
1234:
1232:
1230:
1146:
1097:
962:
733:Vanderbilt Knockout Teams (2) 1978, 2001
685:Men's Board-a-Match Teams (2) 1984, 1987
558:
380:
275:. RuĹľiÄŤka shielded Rosenkranz and other
267:. His mentor, future Nobel Prize winner
2057:
2051:
2039:. Science History Institute. 2016-05-31
1945:
1874:
1865:
1730:
1589:
1556:
1550:
1528:
1513:
1414:
1412:
1379:
1190:
1140:
1086:
727:Open Board-a-Match Teams (2) 1990, 2000
718:Master Mixed Teams (3) 1967, 1984, 1994
347:Universidad Nacional AutĂłnoma de MĂ©xico
2365:
2066:. Pharmaceutical Executive-03-01-2002.
2005:
1999:
1757:
1238:
1034:. Science History Institute. June 2016
998:
996:
903:(Devyn, 1992), with Truscott and Alder
815:(New York: World Publishing Co., 1970)
691:Spingold Knockout Teams (2) 1976, 1984
688:Reisinger Board-a-Match Teams (1) 1985
476:National Academy of Medicine of Mexico
208:
202:
2280:
2184:
1900:
1898:
1813:
1784:
1775:
1363:
1316:
1310:
1227:
1061:
261:Swiss Federal Institute of Technology
2438:Hungarian expatriates in Switzerland
2353:, with 2 library catalog records
1599:Flavell-While, Claudia (June 2010).
1409:
1239:Morell, Virginia (23 January 1989).
1002:
502:
2204:. ACBL. Retrieved 18 December 2014.
2143:Kay-Wolff, Judy (3 December 2011).
2107:The Official Encyclopedia of Bridge
2104:; Francis, Dorthy A., eds. (2001).
1601:"Engineering the sexual revolution"
1419:The New York Times (23 June 2019).
993:
875:– love story and bridge instruction
707:North American Bridge Championships
679:North American Swiss Teams (1) 1990
668:North American Bridge Championships
607:with many gadgets. He invented the
569:North American Bridge Championships
514:Biotechnology Industry Organization
13:
2247:
1904:
1895:
1875:Watkins, Elizabeth Siegel (2007).
1844:
1838:
724:Men's Board-a-Match Teams (1) 1975
682:Grand National Open Teams (1) 1981
398:the last step of the synthesis of
360:Attracting young chemists such as
14:
2479:
2357:List of bridge books by writer, R
2242:
1468:The Pharmaceutical Studies Reader
563:Edith and George Rosenkranz, 2004
310:, a Hungarian immigrant, and Dr.
176:combined oral contraceptive pills
151:, eventually settling in Mexico.
102:, the first orally highly active
2058:Sellers, L. J. (March 1, 2002).
1529:Mandaro, Laura (8 August 2005).
1241:"Rewards Of Intellectual Bigamy"
1147:Juaristi, Eusebio (2 May 2003).
747:Bermuda Bowl qualifiers (1) 1982
730:Spingold Knockout Teams (1) 1967
627:
603:bidding system, an extension of
571:meets, including all four major
242:
230:
221:
32:George Rosenkranz receiving the
2463:20th-century Mexican scientists
2458:21st-century Mexican scientists
2423:Mexican contract bridge players
2223:
2207:
2170:
2159:
2112:American Contract Bridge League
2093:
2070:
2008:"Honoring Syntex's 'Big Three'"
1971:
1577:
1557:Laveaga, Gabriela Soto (2009).
1459:
1357:
1294:. 22 April 2013. Archived from
753:
745:United States Bridge Federation
721:Open Swiss Teams (2) 1998, 2003
351:Institute for Molecular Biology
195:American Contract Bridge League
2453:Naturalized citizens of Mexico
1979:"Biotechnology Heritage Award"
1007:. Oxford: Oxford Univ. Press.
657:Tournament wins and runners-up
385:George Rosenkranz (right) and
1:
2448:Hungarian emigrants to Mexico
2110:(6th ed.). Memphis, TN:
1799:10.1016/S0010-7824(98)00131-0
956:
895:Bid to Win, Play for Pleasure
615:Edith Rosenkranz's kidnapping
538:Condecoracion Eduardo Liceaga
530:and The Chemists' Club, with
2230:"Bridge books reviewed – 53"
2214:"Items by George Rosenkranz"
1707:10.1016/0039-128X(92)90016-3
1217:Chemical Heritage Foundation
1166:10.3998/ark.5550190.0004.b01
880:Bridge books with co-authors
798:Resources in other libraries
779:Resources in other libraries
715:Silver Ribbon Pairs (1) 1992
528:Chemical Heritage Foundation
518:Chemical Heritage Foundation
510:Biotechnology Heritage Award
430:(norethisterone 2 mg +
406:to market norethisterone as
184:Biotechnology Heritage Award
182:In 2012, he was awarded the
34:Biotechnology Heritage Award
7:
2306:
2077:"George Rosenkranz: Mexico"
1491:Rosenkranz, George (2005).
1268:. American Chemical Society
673:Master Mixed Teams (1) 1990
545:Dr. Leopoldo Rio de la Loza
481:New York Academy of Science
106:, used in one of the first
10:
2484:
2145:"Time Marches On ..."
1500:Chemical Heritage Magazine
1493:"The early days of Syntex"
927:Godfrey's Bridge Challenge
907:Godfrey's Bridge Challenge
807:Bridge books by Rosenkranz
741:Other notable 2nd places:
712:Blue Ribbon Pairs (1) 1974
174:used in some of the first
2281:Cohen, Gerald S. (2002).
2275:Science History Institute
2261:Science History Institute
2254:Center for Oral History.
2236:). Retrieved 16 May 2014.
2006:Tweedy, Bryan D. (2004).
1984:Science History Institute
1793:(1 Supplement): 11S–16S.
1536:Investor's Business Daily
1470:. John Wiley & Sons.
1446:American Chemical Society
1350:Science History Institute
1343:Center for Oral History.
1176:2027/spo.5550190.0004.b01
1098:Kornberg, Arthur (2002).
1062:Cohen, Gerald S. (2002).
1003:Ness, Roberta B. (2013).
921:(Devyn, 2001), with Alder
915:(Devyn, 1998), with Alder
909:(Devyn, 1996), with Alder
897:(Devyn, 1990), with Alder
835:Bridge, the Bidder's Game
793:Resources in your library
774:Resources in your library
676:Open Swiss Teams (1) 1991
554:
464:Digital Gene Technologies
252:Science History Institute
241:
229:
220:
215:
130:
120:
113:
94:
86:
67:
45:
25:
18:
2220:. Retrieved 16 May 2014.
2064:Pharmaceutical Executive
1688:Djerassi, C (Dec 1992).
263:, where he received his
108:oral contraceptive pills
2418:Contract bridge writers
2330:World Bridge Federation
2318:World Bridge Federation
2283:"Mexico's Pill Pioneer"
2232:. Pattaya Bridge Club (
2088:World Bridge Federation
1610:: 46–47. Archived from
1137:. Retrieved 1 Oct 2014.
1064:"Mexico's Pill Pioneer"
886:Modern Ideas in Bidding
829:Bid Your Way to the Top
193:Rosenkranz was also an
2037:"Winthrop-Sears Medal"
564:
498:, Israel, board member
486:University of Tel Aviv
470:Scientific memberships
448:norethisterone acetate
438:'s oral contraceptive
394:
332:Mexican barbasco trade
2060:"Pioneering the Pill"
2015:Modern Drug Discovery
1845:Li, Jie Jack (2008).
1765:US patent 2744122
1608:The Chemical Engineer
562:
416:Johnson & Johnson
384:
2428:Bermuda Bowl players
2398:Mexican centenarians
1905:AP (March 4, 1964).
1397:on 17 September 2016
1387:"Rosenkranz, George"
1364:Staff (2016-07-12).
888:(Devyn, 1982), with
841:: Devyn Press, 1985)
787:By George Rosenkranz
644:ACBL Honorary Member
524:Winthrop-Sears Medal
442:with the brand name
426:with the brand name
79:Atherton, California
2468:Jewish centenarians
2393:Mexican biochemists
2351:Library of Congress
2256:"George Rosenkranz"
2191:"Induction by Year"
2166:List of kidnappings
2100:Francis, Henry G.;
1654:1951Natur.168...28R
1345:"George Rosenkranz"
871:(Devyn, 1994), ed.
593:World Team Olympiad
532:Alexander Zaffaroni
370:Alejandro Zaffaroni
339:reverse engineering
209:Scientific research
168:Alejandro Zaffaroni
2388:Mexican scientists
2277:, Philadelphia, PA
2196:2019-05-10 at the
2114:. p. 392-93.
2082:2014-10-06 at the
1959:. 4 September 1996
1910:The New York Times
1617:on 13 January 2014
1425:The New York Times
1133:2014-08-06 at the
863:More Tips for Tops
565:
492:Weizmann Institute
395:
387:Luis E. Miramontes
366:Luis E. Miramontes
164:Luis E. Miramontes
2433:Jewish scientists
2347:George Rosenkranz
2341:ACBL Hall of Fame
2337:George Rosenkranz
2234:Pattaya, Thailand
2102:Truscott, Alan F.
1933:. 31 October 2001
1825:978-0-8135-5009-1
1223:on July 12, 2016.
901:Bidding on Target
765:George Rosenkranz
760:Library resources
634:ACBL Hall of Fame
609:Rosenkranz double
605:Standard American
597:1983 Bermuda Bowl
503:Scientific awards
297:Fulgencio Batista
257:
256:
145:steroid chemistry
141:György Rosenkranz
137:George Rosenkranz
134:
133:
115:Scientific career
20:George Rosenkranz
2475:
2403:Men centenarians
2383:Organic chemists
2333:
2321:
2302:
2300:
2298:
2265:
2237:
2227:
2221:
2218:The Bridge World
2211:
2205:
2188:
2182:
2181:
2178:"Inmate Locator"
2174:
2168:
2163:
2157:
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2154:
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2055:
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2027:
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2022:
2012:
2003:
1997:
1996:
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1992:
1975:
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1968:
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1964:
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1810:
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1755:
1754:
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1728:
1727:
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526:, from the
512:, from the
488:boardmember
424:Ortho-Novum
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2367:Categories
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2297:6 February
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1542:7 February
1372:2016-08-21
1302:7 February
1078:6 February
957:References
701:Runners-up
589:Vanderbilt
444:Norlestrin
188:turned 100
52:1916-08-20
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951:759935172
581:Reisinger
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436:Schering
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408:Norlutin
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277:Jewish
273:Zurich
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