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we have clinical trials, phages won’t become mainstream as a medicine, and that’s where we’re aiming.(...) I get fairly regular emails from doctors and patients wanting phages. Doctors have gone from being completely disinterested to ‘give me the phages now’ (…) There are people who need phages now because they’re dying.”
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Clokie maintained bacteriophages were helping growing numbers of patients in compassionate use cases and could become routine for conditions like chronic UTIs and diabetic foot ulcers. Clokie stated “The risk from antibiotic resistance is dire and getting worse … I find it really shocking. Unless
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and the sequencing of various bacteriophages. She demonstrated that marine phages contain the genes responsible for photosynthesis, and that phages do not only exert pressure on the infection-survival mechanism of cyanobacteria but can acquire the genes of a bacteria's prey.
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can evolve into a new species, with a specific strand that is adapted to spread quickly in hospitals. The new species survives on the sugar-rich diets of
Westerners and can evade common disinfectants.
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and simultaneously defend beneficial bacterial that are typically destroyed by antibiotics. The bacteriophages can be delivered orally and result in destruction of
337:, a bacterial disease that is caused by larvae eating infected leaves. Alongside working on silk worms, Clokie has explored the use of phages in the treatment of
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Nale, Janet Y.; Spencer, Janice; Hargreaves, Katherine R.; Buckley, Anthony M.; Trzepiński, Przemysław; Douce, Gillian R.; Clokie, Martha R. J. (2015).
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847:"University of Leicester research to 'save the most valuable silk moth in the world' — University of Leicester"
344:. She has shown that bacteriophages could be used to treat bacterial disease in pigs. These phages disable the
760:"Bacteriophage Combinations Significantly Reduce Clostridium difficile GrowthIn Vitroand ProliferationIn Vivo"
545:
Molecular studies of
Southern Hemisphere disjunction in three plant genera, Eucryphia, Griselinia and Coriaria
102:
Molecular studies of
Southern Hemisphere disjunction in three plant genera, Eucryphia, Griselinia and Coriaria
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as a lecturer in 2007 and was promoted to
Professor in 2016. She is interested in viruses known as
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Her research includes identifying specific phage combinations that can be used to destroy
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Mann, Nicholas H.; Cook, Annabel; Millard, Andrew; Bailey, Shaun; Clokie, Martha (2003).
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671:"Bacteriophage cocktail shows significant promise for Clostridium difficile infections"
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Bacteria-killing viruses could combat antibiotic resistance, says UK scientist
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and is one of the most valuable silks in the world. They are at risk from
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causes almost two fifths of diarrhoea associated with antibiotics in the
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159:. Her research investigates the identification and development of
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604:. GEN - Genetic Engineering and Biotechnology News. 2019-03-06
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819:"Diarrhea-causing bacteria adapted to spread in hospitals"
711:"Why Scientists Are Trying Viruses To Beat Back Bacteria"
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bacterial disease that infects pigs and can be added to
257:. Clokie started her research career investigating the
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which can be used to treat disease. Her work involves
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885:"A breakthrough to defuse the antibiotic time bomb?"
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that can be used to prevent bacterial infections in
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within two days. Clokie went on to demonstrate that
286:Infections (CDI) while maintaining a healthy gut.
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598:"Phage Therapy: Turning the Tables on Bacteria"
191:, where she started a postgraduate degree in
1121:"PHAGE | Mary Ann Liebert, Inc., publishers"
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1171:: CS1 maint: numeric names: authors list (
1066:"Bacterial photosynthesis genes in a virus"
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397:PHAGE: Therapy, Applications and Research
386:Bacterial photosynthesis genes in a virus
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423:. In 2019 Clokie was interviewed on the
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914:"Therapy could stop superbugs on farms"
552:(PhD thesis). University of Leicester.
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203:. Clokie earned her doctoral degree in
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195:. She earned a master's degree at the
1232:Alumni of the University of Edinburgh
1227:Alumni of the University of Leicester
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951:Bacteriophages: Methods and Protocols
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371:Bacteriophages: Methods and Protocols
187:. She graduated in 1996 and moved to
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413:Bill & Melinda Gates Foundation
255:Scripps Institution of Oceanography
85:Scripps Institution of Oceanography
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415:. This allowed her to investigate
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419:that could be used to eradicate
411:exploration fund award from the
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1025:"Marine cyanophages and light"
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1023:Clokie, Martha R. J. (2006).
974:Clokie, Martha R. J. (2011).
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912:Ghosh, Pallab (2017-06-08).
381:Marine cyanophages and light
245:After her PhD, Clokie was a
211:in 2001 for research on the
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167:in an effort to develop new
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10:
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1237:Women molecular biologists
1029:Environmental Microbiology
366:Her publications include;
145:Martha Rebecca Jane Clokie
33:Martha Rebecca Jane Clokie
677:. University of Leicester
630:. University of Leicester
461:. University of Leicester
455:"Professor Martha Clokie"
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342:urinary tract infections
283:Clostridioides difficile
949:Clokie, Martha (2009).
315:She has also worked on
266:University of Leicester
247:postdoctoral researcher
209:University of Leicester
197:University of Edinburgh
157:University of Leicester
81:University of Leicester
53:University of Leicester
48:University of Edinburgh
992:10.4161/bact.1.1.14942
953:. Springer Protocols.
497:Europe PubMed Central
407:Clokie was awarded a
362:Selected publications
251:University of Warwick
199:in 1997 and moved to
89:University of Warwick
776:10.1128/aac.01774-15
322:Antheraea assamensis
185:University of Dundee
43:University of Dundee
1125:home.liebertpub.com
430:The Life Scientific
391:Clokie is founding
259:molecular evolution
241:Research and career
976:"Phages in nature"
574:uk.bl.ethos.696943
522:kisacoresearch.com
495:publications from
403:Awards and honours
325:(Muga silkworms).
264:Clokie joined the
1035:(12): 2074–2082.
960:978-1-60327-564-4
524:. Kisaco Research
205:molecular ecology
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1194:. Retrieved
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261:of plants.
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193:biodiversity
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153:Microbiology
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130:/departments
100:
77:Institutions
71:Microbiology
60:
891:. Pig World
425:BBC Radio 4
421:Shigellosis
219:of plants:
1211:Categories
1196:2019-11-16
1158:2019-11-16
1130:2019-11-16
919:2019-11-16
895:2019-11-16
856:2019-11-16
828:2019-11-16
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681:2019-11-16
634:2019-11-16
608:2019-11-16
566:1063547917
558:2381/29823
528:2019-11-16
465:2019-11-16
437:References
427:programme
347:Salmonella
228:Griselinia
163:that kill
1092:0028-0836
784:0066-4804
335:Flacherie
327:Muga silk
222:Eucryphia
215:of three
213:evolution
201:Leicester
189:Edinburgh
175:Education
165:pathogens
149:Professor
132:/genetics
1167:cite web
1153:le.ac.uk
1100:12917674
1051:17107549
1010:21687533
865:cite web
851:le.ac.uk
802:26643348
690:cite web
675:le.ac.uk
643:cite web
628:le.ac.uk
474:cite web
459:le.ac.uk
352:pig feed
253:and the
234:Coriaria
1147:ap507.
1001:3109452
845:ap507.
793:4750681
715:NPR.org
669:ap507.
622:aijh1.
453:rjs29.
249:at the
207:at the
183:at the
181:biology
155:at the
134:/people
117:Website
1098:
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1070:Nature
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217:genera
107:(2001)
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96:Thesis
67:Fields
570:EThOS
331:Assam
147:is a
55:(PhD)
50:(MSc)
45:(BSc)
1173:link
1096:PMID
1088:ISSN
1047:PMID
1006:PMID
955:ISBN
871:link
798:PMID
780:ISSN
696:link
649:link
562:OCLC
480:link
354:.
231:and
122:www2
29:Born
1191:BBC
1078:doi
1074:424
1037:doi
996:PMC
988:doi
788:PMC
772:doi
554:hdl
288:CDI
237:.
151:of
128:.uk
126:.ac
124:.le
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