651:
628:
2195:"None of the meloxicam treatment groups demonstrated inhibition of platelet aggregation to either arachidonic acid (AC) or adenosine diphosphate (ADP). However, there were no significant changes in the platelet count, prothrombin and activated partial thromboplastin time in any of the meloxicam and indomethacin groups. Other crossover studies also confirmed that meloxicam 15 mg/day caused a major reduction of maximum thromboxane production, but no reduction in collagen- or AC-induced platelet aggregation.
40:
4489:
4509:
31:
4499:
4535:
2059:
2020:
3209:
following changes or signs in your dog: Limping or lameness, decreased activity or exercise (reluctance to stand, climb stairs, jump or run, or difficulty in performing these activities), stiffness or decreased movement of joints. Metacam is given to dogs by mouth. Do not use
Metacam Oral Suspension in cats.
1067:. The free fraction in synovial fluid is 2.5 times higher than in plasma, due to the lower albumin content in synovial fluid as compared to plasma. The significance of this penetration is unknown, but it may account for the fact that it performs exceptionally well in treatment of arthritis in animal models.
1237:
The data sheets for meloxicam products for cats also state that: "Meloxicam has a narrow therapeutic safety margin in cats and clinical signs of overdose may be seen at relatively small overdose levels." The dosage policy for meloxicam oral suspension products for cats as described in the data sheets
1233:
such as loss of appetite, vomiting, diarrhoea, faecal occult blood, apathy and renal failure have occasionally been reported. These side effects are in most cases transient and disappear following termination of the treatment but in very rare cases may be serious or fatal." However, the main page of
1225:
and has added the following boxed warning to the products' label: "Repeated use of meloxicam in cats has been associated with acute renal failure and death. Do not administer additional injectable or oral meloxicam to cats. See
Contraindications, Warnings, and Precautions for detailed information."
2192:
Meloxicam is extensively bound to plasma proteins (99.4%), primarily to albumin. Meloxicam has an apparent volume of distribution (Vd) 10 – 15 L in humans (0.1 – 0.2 L/kg) after oral administration and a mean volume of distribution at steady-state of 0.2 L/kg after intravenous administration."
3208:
Metacam is a prescription non-steroidal anti-inflammatory drug (NSAID) that is used to control pain and inflammation (soreness) due to osteoarthritis in dogs. Osteoarthritis (OA) is a painful condition caused by "wear and tear" of cartilage and other parts of the joints that may result in the
1246:
advocates that the use of total body weight in obese adults may lead to drug toxicity and suggests individualised dosing based on the patient's ideal rather than actual body weight, and, on the other hand, precisely because the range safety of meloxicam for cats is so limited.
1914:"Improvement in gastrointestinal tolerability of the selective cyclooxygenase (COX)-2 inhibitor, meloxicam, compared with piroxicam: results of the Safety and Efficacy Large-scale Evaluation of COX-inhibiting Therapies (SELECT) trial in osteoarthritis"
1171:
In healthy dogs given meloxicam, no perioperative adverse effects on the cardiovascular system have been reported at recommended dosages. Perioperative administration of meloxicam to cats did not affect postoperative respiratory rate nor heart rate.
2331:
Engelhardt G, Homma D, Schlegel K, Utzmann R, Schnitzler C (October 1995). "Anti-inflammatory, analgesic, antipyretic and related properties of meloxicam, a new non-steroidal anti-inflammatory agent with favourable gastrointestinal tolerance".
919:
to be updated for all nonsteroidal anti-inflammatory medications to describe the risk of kidney problems in unborn babies that result in low amniotic fluid. They recommend avoiding NSAIDs in pregnant women at 20 weeks or later in pregnancy.
1342:
In
October 2004, a formulation for use in cats was approved for use prior to surgery only. This is an injectable meloxicam, indicated for as a single, one-time dose only, with specific and repeated warnings not to administer a second dose.
1132:
Meloxicam is predominantly excreted in the form of metabolites and occurs to equal extents in the urine and feces. Traces of unchanged parent drug are found in urine and feces. The mean elimination half-life ranges from 15 to 20 hours.
1392:
As of June 2008, meloxicam is registered for long-term use in cats in
Australia, New Zealand, and Canada. In the United Kingdom, meloxicam is licensed for use in cats, guinea pigs, horses, and livestock including pigs and cattle.
3495:
967:
are at risk for cardiovascular side effects. People with family history of heart disease, heart attack, or stroke should tell their treating physician as the potential for serious cardiovascular side effects is significant.
1259:
signs such as seizures and comas in cats. It adds that cats have a low tolerance for NSAIDs. Also, in another scientific journal there is talk of research according to which cats that received meloxicam had greater
1234:
the official website of the same meloxicam product states: "Important Safety
Information: DO NOT USE ORAL SUSPENSION IN CATS. Acute renal failure and death have been associated with the use of meloxicam in cats."
2111:
Zeidan AZ, Al Sayed B, Bargaoui N, Djebbar M, Djennane M, Donald R, et al. (April 2013). "A review of the efficacy, safety, and cost-effectiveness of COX-2 inhibitors for Africa and the Middle East region".
1250:
Some additional information about giving meloxicam to cats from researchers is as follows: A peer-reviewed journal article cites NSAIDs, including meloxicam, as causing gastrointestinal upset and, at high doses,
1141:
Use of meloxicam is not recommended in people with peptic ulcer disease or increased gastrointestinal bleed risk, including those over 75 years of age or those taking medications associated with bleeding risk.
2458:
2019 American
Geriatrics Society Beers Criteria Update Expert Panel (April 2019). "American Geriatrics Society 2019 Updated AGS Beers Criteria® for Potentially Inappropriate Medication Use in Older Adults".
1088:. Use of oral meloxicam following a high-fat breakfast increases the mean peak drug levels by about 22%; however, the manufacturer does not make any specific meal recommendations. In addition, the use of
1195:
The issue of using meloxicam in cats involves conflicting guidelines, differing legislation, and a narrow therapeutic safety margin that can easily turn the drug from cure to poison. More specifically:
3261:
3225:
3153:
1726:
3327:
2956:
948:
function. A pooled analysis of randomized, controlled studies of meloxicam therapy of up to 60 days duration found that meloxicam was associated with a statistically significantly lower number of
3189:
1873:"Gastrointestinal tolerability of meloxicam compared to diclofenac in osteoarthritis patients. International MELISSA Study Group. Meloxicam Large-scale International Study Safety Assessment"
2040:
2769:
223:
1997:
2788:
3451:
3311:
1464:
1092:
does not show pharmacokinetic interactions. With chronic dosing, the time to maximum plasma concentration following oral administration is approximately 5–6 hours.
726:
1229:
Another conflicting guideline concerns a specific meloxicam oral suspension product for cats. Its instruction sheet states that: "Typical adverse reactions of
2076:
Stamm O, Latscha U, Janecek P, Campana A (January 1976). "Development of a special electrode for continuous subcutaneous pH measurement in the infant scalp".
4492:
1955:"A six-month double-blind trial to compare the efficacy and safety of meloxicam 7.5 mg daily and naproxen 750 mg daily in patients with rheumatoid arthritis"
1715:
168:
3561:
2207:
Singh G, Lanes S, Triadafilopoulos G (July 2004). "Risk of serious upper gastrointestinal and cardiovascular thromboembolic complications with meloxicam".
3517:
3374:
2948:
784:
1346:
In 2005, the FDA sent a Notice of
Violation to the manufacturer for its promotional materials which included promotion of the drug for off-label use.
3272:
3236:
3164:
952:
complications than the NSAID diclofenac (0.2% versus 0.8% respectively) but a similar incidence of thromboembolic events to naproxen and piroxicam.
4560:
3338:
2990:
3909:
995:
It is recommended to withhold meloxicam use for at least four to six half-lives prior to surgical or dental procedures due to increased risk for
3200:
1264:
at 6 months than cats that received placebo. It was concluded that meloxicam should be used with caution in cats with chronic kidney disease.
987:, and perforation of the stomach or intestines, which can be fatal. Elderly patients are at greater risk for serious gastrointestinal events.
4585:
1084:
of meloxicam is decreased when administered orally compared to an equivalent IV bolus dose. Different oral formulations of meloxicam are not
62:
3300:
2606:
Boström IM, Nyman G, Hoppe A, Lord P (January 2006). "Effects of meloxicam on renal function in dogs with hypotension during anaesthesia".
2569:
2250:
1720:
1350:
740:
1377:
4580:
4208:
3984:
1765:
874:
million prescriptions. An intravenous version of meloxicam (Anjeso) was approved for medical use in the United States in
February 2020.
3924:
3884:
3539:
2643:"Effect of non-steroidal anti-inflammatory drugs on postoperative respiratory and heart rate in cats subjected to ovariohysterectomy"
1215:
meloxicam spray for cats because after reviewing numerous reports of meloxicam side effects in cats, it has identified many cases of
1180:
4502:
3554:
2750:
3436:
2770:"What Veterinarians Should Advise Clients About Pain Control and Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) in Dogs and Cats"
2530:
2505:
1842:
1530:
1505:
3308:
3077:
Khan SA, McLean MK (March 2012). "Toxicology of frequently encountered nonsteroidal anti-inflammatory drugs in dogs and cats".
2158:
Gates BJ, Nguyen TT, Setter SM, Davies NM (October 2005). "Meloxicam: a reappraisal of pharmacokinetics, efficacy and safety".
3477:
4467:
2558:
1795:
1688:
1331:) formulation of meloxicam. In January 2005, the product insert added a warning in bold-face type: "Do not use in cats." An
3570:
1349:
In
February 2020, meloxicam injection was approved for use in the United States. The FDA granted the approval of Anjeso to
1016:
3114:"Pharmacokinetics of meloxicam in koalas (Phascolarctos cinereus) after intravenous, subcutaneous and oral administration"
4148:
3547:
976:
883:
809:
2589:
1319:
In 2003, meloxicam was approved in the U.S. for use in dogs for the management of pain and inflammation associated with
827:
Common side effects include abdominal pain, dizziness, swelling, headache, and a rash. Serious side effects may include
2832:
3154:"NADA 141-213: New Animal Drug Application Approval (for Metacam (meloxicam) 0.5 mg/mL and 1.5 mg/mL Oral Suspension)"
2433:
3489:
3416:
2309:
1759:
1643:
791:
768:
InChI=1S/C14H13N3O4S2/c1-8-7-15-14(22-8)16-13(19)11-12(18)9-5-3-4-6-10(9)23(20,21)17(11)2/h3-7,18H,1-2H3,(H,15,16,19)
760:
113:
1998:"FDA Warns that Using a Type of Pain and Fever Medication in Second Half of Pregnancy Could Lead to Complications"
2280:
369:
208:
94:
1100:
The mean volume of distribution of meloxicam is approximately 10 L. It is highly protein-bound, mainly to
3363:
1226:
In contrast, in the
European Union and other continents or countries, the use of the drug in cats is allowed.
862:
Meloxicam was patented in 1977 and approved for medical use in the United States in 2000. It was developed by
448:
1273:
3370:
3334:
3268:
3232:
3196:
3160:
2003:
1336:
1200:
912:
889:
840:
646:
499:
1953:
Wojtulewski JA, Schattenkirchner M, Barceló P, Le Loët X, Bevis PJ, Bluhmki E, et al. (April 1996).
1436:"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)"
607:
3569:
4525:
2979:
870:. In 2022, it was the 29th most commonly prescribed medication in the United States, with more than 18
568:
4595:
1435:
1276:
of meloxicam from the stomach is not affected by the presence of food, with the peak concentration (
4575:
4570:
4446:
2576:
Part IV, Looking Beyond Butorphanol, Sep 2006, Veterinary Anesthesia & Analgesia Support Group.
2457:
623:
1361:
In Europe the product is licensed for other anti-inflammatory benefits including relief from both
4555:
4471:
3297:
2806:
2242:
1912:
Dequeker J, Hawkey C, Kahan A, SteinbrĂĽck K, Alegre C, Baumelou E, et al. (September 1998).
1555:
150:
52:
2566:
1376:
Meloxicam was authorised for use in cattle throughout the European Union in January 1998, via a
3408:
1871:
Hawkey C, Kahan A, SteinbrĂĽck K, Alegre C, Baumelou E, BĂ©gaud B, et al. (September 1998).
1328:
1256:
980:
589:
300:
3015:
KuKanich K, George C, Roush JK, Sharp S, Farace G, Yerramilli M, et al. (February 2021).
1749:
488:
4565:
4451:
4441:
4436:
4426:
1402:
1145:
Adverse events have been found to be dose-dependent and associated with length of treatment.
1000:
548:
439:
3400:
4421:
4398:
3879:
3751:
3112:
Kimble B, Black LA, Li KM, Valtchev P, Gilchrist S, Gillett A, et al. (October 2013).
1716:"Baudax Bio Announces FDA Approval of Anjeso for the Management of Moderate to Severe Pain"
1369:
in dogs. Meloxicam is also licensed for use in horses, to relieve the pain associated with
1284:
960:
863:
508:
403:
331:
1164:
The most common side effects include gastrointestinal irritation (vomiting, diarrhea, and
8:
4475:
4431:
4348:
3726:
3210:
1971:
1954:
1299:
1277:
1252:
1217:
1154:
824:. It is recommended that it be used for as short a period as possible and at a low dose.
394:
157:
3041:
3016:
2789:"Information about the Boxed Warning on Meloxicam Labels regarding Safety Risks in Cats"
2667:
2642:
650:
627:
4590:
4338:
4271:
3054:
2925:
2900:
2726:
2699:
2680:
2484:
2406:
2379:
2357:
2183:
2137:
1617:
867:
124:
2089:
4508:
4368:
4218:
3781:
3756:
3485:
3412:
3401:
3135:
3094:
3058:
3046:
2930:
2731:
2698:
Swan G, Naidoo V, Cuthbert R, Green RE, Pain DJ, Swarup D, et al. (March 2006).
2672:
2623:
2619:
2476:
2411:
2349:
2224:
2175:
2141:
2129:
2125:
2093:
1976:
1935:
1894:
1755:
1639:
1621:
1609:
1605:
1045:
813:
579:
247:
235:
86:
2684:
2488:
2361:
2187:
1930:
1913:
1889:
1872:
428:
4600:
4132:
3125:
3086:
3036:
3028:
2920:
2912:
2721:
2711:
2662:
2654:
2615:
2468:
2401:
2391:
2341:
2216:
2167:
2121:
2085:
1966:
1925:
1884:
1601:
1044:, which are mediators of inflammation. Meloxicam has been shown, especially at low
1034:
1030:
848:
844:
663:
282:
191:
181:
2555:
1787:
4539:
4512:
4250:
4240:
4198:
3664:
3582:
3315:
3304:
2916:
2833:"Cats: Meloxicam Question for Department for Environment, Food and Rural Affairs"
2716:
2593:
2573:
2562:
2220:
1817:
1680:
1422:
1370:
1303:
1081:
896:(a sign of intestinal bleeding). It has fewer gastrointestinal side effects than
310:
290:
72:
3578:
3574:
1324:
932:, its use is associated with an increased risk of cardiovascular events such as
4224:
3999:
3864:
3776:
3701:
3686:
3681:
3675:
3604:
3090:
2396:
2171:
1320:
1124:
activity is thought to be responsible for the other two remaining metabolites.
1060:
1022:
916:
817:
39:
4549:
4358:
4235:
4048:
4033:
3914:
3849:
3032:
2658:
2641:
Höglund OV, Dyall B, Gräsman V, Edner A, Olsson U, Höglund K (October 2018).
2586:
2063:
2024:
1469:
1158:
1085:
1041:
836:
828:
639:
260:
3190:"Client Information Sheet For Metacam (meloxicam) 1.5 mg/mL Oral Suspension"
4230:
4193:
4178:
4122:
4107:
4102:
4053:
4028:
4018:
4013:
3771:
3649:
3629:
3624:
3614:
3596:
3139:
3098:
3050:
2934:
2735:
2700:"Removing the threat of diclofenac to critically endangered Asian vultures"
2676:
2627:
2480:
2429:
2415:
2305:
2228:
2179:
2133:
1381:
1366:
1165:
1064:
956:
933:
186:
176:
2353:
1980:
1939:
1898:
1613:
1283:) of meloxicam occurring in the blood 7–8 hours after administration. The
22:
4466:
indicates initially developed first-in-class compound of specific group;
4363:
4343:
4312:
4297:
4188:
4153:
4142:
3952:
3874:
3802:
3791:
3741:
3736:
2246:
1952:
1261:
941:
821:
161:
80:
468:
4393:
4383:
4378:
4373:
4322:
4287:
4137:
4085:
4080:
4075:
4070:
4043:
3967:
3904:
3843:
3837:
3812:
3807:
3746:
3731:
3721:
3691:
3659:
3644:
3591:
2345:
2272:
2097:
1362:
1332:
1203:(Food & Drug Administration) approves the use of meloxicam in cats
1176:
1121:
1004:
949:
897:
702:
479:
3130:
3113:
2854:"Clinical particulars - Meloxidyl® 0.5 mg/ml oral suspension for cats"
2472:
2380:"Meloxicam in the management of post-operative pain: Narrative review"
1465:"Health product highlights 2021: Annexes of products approved in 2021"
4388:
4353:
4317:
4307:
4302:
4292:
4282:
4277:
4266:
4260:
4213:
4127:
4112:
4097:
4065:
4059:
4023:
3989:
3978:
3934:
3899:
3894:
3889:
3869:
3832:
3827:
3761:
3716:
3669:
3634:
3619:
2276:
996:
901:
856:
414:
344:
66:
2853:
4203:
4183:
4169:
4117:
4091:
4038:
3962:
3957:
3929:
3919:
3859:
3854:
3822:
3654:
3639:
3609:
3017:"Effects of low-dose meloxicam in cats with chronic kidney disease"
1240:
There is no separate dosage guideline for overweight or obese cats.
964:
945:
944:
A, it does not appear to do so at levels that would interfere with
905:
528:
459:
108:
3226:"NADA 141-219: Metacam (meloxicam) 5 mg/mL Solution for Injection"
2554:
Off-label use discussed in: Arnold Plotnick MS, DVM, ACVIM, ABVP,
725:
595:
4403:
4004:
3817:
3766:
3710:
3437:"Generic and biosimilar medicinal products in the European Union"
3213:
and death have been associated with the use of meloxicam in cats.
2062:
This article incorporates text from this source, which is in the
2023:
This article incorporates text from this source, which is in the
1184:
1112:
Meloxicam is extensively metabolized in the liver by the enzymes
1101:
1089:
30:
1238:
defines the amount administered as proportional to body weight.
3944:
3262:"Metacam 5 mg/mL Solution for Injection, Supplemental Approval"
1638:(76 ed.). Pharmaceutical Press. 2018. pp. 1112–1113.
1230:
1117:
1113:
1026:
937:
908:, and perhaps all other NSAIDs which are not COX-2 selective.
893:
852:
832:
559:
323:
319:
3079:
The Veterinary Clinics of North America. Small Animal Practice
2786:
2767:
2748:
2330:
2878:
2110:
1911:
1818:"Meloxicam Drug Usage Statistics, United States, 2013 - 2022"
1291:
1242:
This is worth mentioning on the one hand because the article
1221:
1053:
1049:
984:
929:
716:
539:
353:
349:
315:
2306:"Meloxicam official FDA information, side effects, and uses"
612:
2523:
1870:
519:
3399:
Maddison JE, Page SW, Church D, eds. (2008). "Meloxicam".
2585:
For off-label use example in rabbits, see Krempels, Dana,
2377:
2206:
2075:
1298:), very little meloxicam is absorbed into the blood after
1207:
and only as a one-time injection given before surgery. It
2500:
2498:
1443:
3014:
2949:"Toxicology Brief: The 10 most common toxicoses in cats"
2640:
2041:"NSAIDs may cause rare kidney problems in unborn babies"
3407:(2nd ed.). Edinburgh: Saunders/Elsevier. pp.
2837:
UK Parliament Written questions, answers and statements
2697:
2157:
2495:
2035:
2033:
4523:
3111:
2605:
1335:
formulation for use in dogs was approved by the U.S.
1175:
Meloxicam has been investigated as an alternative to
2749:
Center for Veterinary Medicine (29 September 2022).
2691:
3364:"Anjeso (meloxicam) injection, for intravenous use"
3118:
Journal of Veterinary Pharmacology and Therapeutics
2030:
1428:
447:
3398:
1992:
1990:
1415:
2787:Center for Veterinary Medicine (14 August 2023).
2768:Center for Veterinary Medicine (15 August 2023).
1500:
1498:
1496:
1494:
1492:
1490:
1488:
4547:
2384:Journal of Anaesthesiology Clinical Pharmacology
1287:of meloxicam is approximately 24 hours in dogs.
427:
1987:
1747:
1592:Noble S, Balfour JA (March 1996). "Meloxicam".
1523:
812:(NSAID) used to treat pain and inflammation in
402:
3430:
3428:
2373:
2371:
1485:
855:family of chemicals and is closely related to
748:Cc1cnc(s1)NC(=O)C\3=C(/O)c2ccccc2S(=O)(=O)N/3C
3555:
3475:
2977:
2751:"Get the Facts about Pain Relievers for Pets"
2378:Bekker A, Kloepping C, Collingwood S (2018).
2078:American Journal of Obstetrics and Gynecology
1161:in other animals such as cattle and exotics.
3072:
3070:
3068:
2300:
2298:
2153:
2151:
1710:
1708:
1706:
1591:
892:toxicity and bleeding, headaches, rash, and
385:-1,2-benzothiazine-3-carboxamide-1,1-dioxide
112:
3469:
3425:
2368:
1675:
1587:
1585:
1583:
1581:
1579:
1577:
1190:
940:. Although meloxicam inhibits formation of
16:Nonsteroidal anti-inflammatory drug (NSAID)
3562:
3548:
3182:
3076:
2898:
2587:Hind Limb Paresis and Paralysis in Rabbits
2461:Journal of the American Geriatrics Society
2104:
1673:
1671:
1669:
1667:
1665:
1663:
1661:
1659:
1657:
1655:
1211:meloxicam oral suspension for cats and it
649:
626:
487:
3129:
3065:
3040:
2924:
2725:
2715:
2666:
2596:, University of Miami Biology Department.
2430:"Meloxicam (Professional Patient Advice)"
2405:
2395:
2295:
2148:
1970:
1929:
1888:
1866:
1864:
1703:
1181:Royal Society for the Protection of Birds
979:cause an increase in the risk of serious
507:
2531:"Metacam- meloxicam injection, solution"
1636:British national formulary : BNF 76
1574:
1384:meloxicam product was approved in 2006.
1120:(minor) into four inactive metabolites.
4561:Drugs developed by Boehringer Ingelheim
3235:(FDA). 12 November 2003. Archived from
1741:
1681:"Meloxicam Monograph for Professionals"
1652:
1136:
622:
467:
85:
4548:
3434:
3309:clinical dosing instructions for cats.
3271:(FDA). 28 October 2004. Archived from
3021:Journal of Feline Medicine and Surgery
2980:"The 10 most common toxicoses in cats"
2647:Journal of Feline Medicine and Surgery
1861:
1754:. John Wiley & Sons. p. 519.
1423:Use During Pregnancy and Breastfeeding
1010:
640:
269:
241:
3571:Non-steroidal anti-inflammatory drugs
3543:
3498:from the original on 1 September 2020
3380:from the original on 22 February 2020
2848:
2846:
2807:"Metacam | European Medicines Agency"
2453:
2451:
2283:from the original on 16 November 2014
2253:from the original on 29 November 2014
2200:
1729:from the original on 21 February 2020
1691:from the original on 23 December 2018
1421:
1267:
866:; however, it is also available as a
588:
567:
547:
254:
103:
71:
4586:Nonsteroidal anti-inflammatory drugs
4498:
3482:Clinical medicine of the dog and cat
3457:from the original on 28 January 2020
3337:(FDA). 19 April 2005. Archived from
3163:(FDA). 15 April 2003. Archived from
2879:"Meloxidyl® from Ceva Animal Health"
2608:Veterinary Anaesthesia and Analgesia
1628:
1040:—the first step in the synthesis of
1017:Non-steroidal anti-inflammatory drug
594:
190:
180:
4149:COX-inhibiting nitric oxide donator
3476:Gaschen FP, Schaer M, eds. (2016).
3199:(FDA). January 2005. Archived from
2959:from the original on 29 August 2018
1798:from the original on 30 August 2024
1725:(Press release). 20 February 2020.
1378:centralised marketing authorisation
1070:
983:adverse events including bleeding,
971:
884:Nonsteroidal anti-inflammatory drug
810:nonsteroidal anti-inflammatory drug
527:
418:
13:
4581:Medicine in the United States Navy
3403:Small animal clinical pharmacology
2996:from the original on 9 August 2019
2843:
2448:
2436:from the original on 6 August 2019
2312:from the original on 16 March 2010
1972:10.1093/rheumatology/35.suppl_1.22
1387:
1063:range from 40% to 50% of those in
877:
14:
4612:
2978:Merola V, Dunayer E (June 2006).
2899:Barras M, Legg A (October 2017).
2160:Expert Opinion on Pharmacotherapy
2045:U.S. Food and Drug Administration
1768:from the original on 10 July 2020
1356:
1148:
923:
217:
135:
4533:
4507:
4497:
4488:
4487:
3522:Veterinary Medicines Directorate
2620:10.1111/j.1467-2995.2005.00208.x
2209:The American Journal of Medicine
2126:10.1111/j.1533-2500.2012.00591.x
2057:
2018:
2008:(Press release). 15 October 2020
1606:10.2165/00003495-199651030-00007
1600:(3): 424–30, discussion 431–32.
1314:
839:. Use is not recommended in the
680:
674:
38:
29:
4399:Superoxide dismutase / orgotein
3510:
3392:
3356:
3320:
3290:
3254:
3218:
3146:
3105:
3008:
2971:
2941:
2892:
2871:
2825:
2799:
2780:
2761:
2742:
2634:
2599:
2579:
2548:
2506:"Metacam- meloxicam suspension"
2422:
2324:
2265:
2235:
2069:
1959:British Journal of Rheumatology
1946:
1918:British Journal of Rheumatology
1905:
1877:British Journal of Rheumatology
1835:
1810:
1780:
1748:Fischer J, Ganellin CR (2006).
1309:
1095:
773:Key:ZRVUJXDFFKFLMG-UHFFFAOYSA-N
3711:Aspirin (acetylsalicylic acid)
3518:"Product Information Database"
1548:
1457:
692:
686:
668:
230:
1:
2901:"Drug dosing in obese adults"
2567:Perioperative Pain Management
2556:Pain Management using Metacam
2090:10.1016/S0002-9378(16)33297-5
1931:10.1093/rheumatology/37.9.946
1890:10.1093/rheumatology/37.9.937
1843:"Anjeso- meloxicam injection"
1751:Analogue-based Drug Discovery
1531:"Anjeso- meloxicam injection"
1408:
1157:to treat dogs, but also sees
1107:
1075:
3371:Food and Drug Administration
3335:Food and Drug Administration
3269:Food and Drug Administration
3233:Food and Drug Administration
3197:Food and Drug Administration
3161:Food and Drug Administration
2917:10.18773/austprescr.2017.053
2717:10.1371/journal.pbio.0040066
2221:10.1016/j.amjmed.2004.03.012
2004:Food and Drug Administration
1337:Food and Drug Administration
1183:(RSPB) to prevent deaths of
1127:
1059:Meloxicam concentrations in
913:Food and Drug Administration
888:Meloxicam use can result in
847:(COX-2) more than it blocks
841:third trimester of pregnancy
820:. It is used by mouth or by
804:, sold under the brand name
7:
3777:Salicylic acid (salicylate)
3484:(3rd ed.). CRC Press.
3478:"Recent NSAID developments"
1396:
1244:Drug dosing in obese adults
1029:responsible for converting
10:
4617:
3091:10.1016/j.cvsm.2012.01.003
2397:10.4103/joacp.JOACP_133_18
2172:10.1517/14656566.6.12.2117
1014:
911:In October 2020, the U.S.
881:
658:Chemical and physical data
4483:
4460:
4412:
4331:
4249:
4162:
3998:
3943:
3790:
3700:
3590:
2308:. Drugs.com. March 2010.
1560:European Medicines Agency
1506:"Mobic- meloxicam tablet"
1048:, to selectively inhibit
781:
756:
736:
714:
701:
662:
657:
638:
606:
578:
558:
538:
518:
498:
478:
458:
438:
413:
393:
381:-(5-methyl-2-thiazolyl)-2
365:
360:
343:
330:
309:
299:
289:
281:
207:
202:
167:
149:
123:
93:
79:
61:
51:
46:
37:
28:
4447:Naproxen/diphenhydramine
3314:6 September 2008 at the
3307:on its website, and its
3033:10.1177/1098612X20935750
2858:www.noahcompendium.co.uk
2659:10.1177/1098612X17742290
1339:(FDA) in November 2003.
1191:Use of meloxicam in cats
990:
894:very dark or black stool
4468:WHO-Essential Medicines
3435:Wright E (March 2007).
3296:See the manufacturer's
1205:only in injectable form
835:, kidney problems, and
3796:and related substances
3373:(FDA). February 2020.
3085:(2): 289–306, vi–vii.
1302:(that is, it has poor
1296:Phascolarctos cinereus
851:(COX-1). It is in the
4452:Naproxen/esomeprazole
4442:Meloxicam/bupivacaine
4437:Ibuprofen/paracetamol
4427:Ibuprofen/hydrocodone
3328:"Notice of Violation"
3206:on 15 November 2017.
2905:Australian Prescriber
2572:18 April 2010 at the
2565:, and Stein, Robert,
2334:Inflammation Research
1788:"The Top 300 of 2022"
1403:Bupivacaine/meloxicam
1153:Meloxicam is used in
1001:ulcerative stomatitis
822:injection into a vein
4422:Ibuprofen/famotidine
3880:Indometacin farnesil
3752:Magnesium salicylate
3573:(NSAIDs) (primarily
2592:17 June 2010 at the
2561:14 July 2011 at the
1137:Specific populations
864:Boehringer Ingelheim
4432:Ibuprofen/oxycodone
4349:Chondroitin sulfate
3727:Carbasalate calcium
3303:2 July 2011 at the
3278:on 15 November 2017
3242:on 15 November 2017
3211:Acute kidney injury
2987:Veterinary Medicine
1300:oral administration
1253:acute kidney injury
1218:acute renal failure
1155:veterinary medicine
1011:Mechanism of action
915:(FDA) required the
808:among others, is a
377:4-Hydroxy-2-methyl-
250:(Prescription only)
226:(Prescription only)
25:
4339:Aminopropionitrile
3344:on 13 January 2017
2346:10.1007/BF01757699
1849:. 22 February 2022
1562:. 8 September 2023
868:generic medication
814:rheumatic diseases
21:
4521:
4520:
4369:Glycosaminoglycan
4219:Meclofenamic acid
3782:Sodium salicylate
3757:Methyl salicylate
3131:10.1111/jvp.12038
2811:www.ema.europa.eu
2473:10.1111/jgs.15767
2166:(12): 2117–2140.
1965:(Suppl 1): 22–8.
1046:therapeutic doses
1021:Meloxicam blocks
799:
798:
727:Interactive image
608:CompTox Dashboard
273:
258:
245:
233:
221:
139:
106:
4608:
4596:Veterinary drugs
4538:
4537:
4536:
4529:
4511:
4501:
4500:
4491:
4490:
4251:COX-2 inhibitors
4166:-arylanthranilic
4133:Tiaprofenic acid
3564:
3557:
3550:
3541:
3540:
3534:
3533:
3531:
3529:
3514:
3508:
3507:
3505:
3503:
3473:
3467:
3466:
3464:
3462:
3456:
3441:
3432:
3423:
3422:
3406:
3396:
3390:
3389:
3387:
3385:
3379:
3368:
3360:
3354:
3353:
3351:
3349:
3343:
3332:
3324:
3318:
3294:
3288:
3287:
3285:
3283:
3277:
3266:
3258:
3252:
3251:
3249:
3247:
3241:
3230:
3222:
3216:
3215:
3205:
3194:
3186:
3180:
3179:
3177:
3175:
3169:
3158:
3150:
3144:
3143:
3133:
3109:
3103:
3102:
3074:
3063:
3062:
3044:
3012:
3006:
3005:
3003:
3001:
2995:
2984:
2975:
2969:
2968:
2966:
2964:
2945:
2939:
2938:
2928:
2896:
2890:
2889:
2887:
2885:
2875:
2869:
2868:
2866:
2864:
2850:
2841:
2840:
2829:
2823:
2822:
2820:
2818:
2803:
2797:
2796:
2784:
2778:
2777:
2765:
2759:
2758:
2746:
2740:
2739:
2729:
2719:
2695:
2689:
2688:
2670:
2638:
2632:
2631:
2603:
2597:
2583:
2577:
2552:
2546:
2545:
2543:
2541:
2527:
2521:
2520:
2518:
2516:
2502:
2493:
2492:
2455:
2446:
2445:
2443:
2441:
2426:
2420:
2419:
2409:
2399:
2375:
2366:
2365:
2328:
2322:
2321:
2319:
2317:
2302:
2293:
2292:
2290:
2288:
2269:
2263:
2262:
2260:
2258:
2239:
2233:
2232:
2204:
2198:
2197:
2155:
2146:
2145:
2108:
2102:
2101:
2073:
2067:
2061:
2060:
2056:
2054:
2052:
2037:
2028:
2022:
2021:
2017:
2015:
2013:
1994:
1985:
1984:
1974:
1950:
1944:
1943:
1933:
1909:
1903:
1902:
1892:
1868:
1859:
1858:
1856:
1854:
1839:
1833:
1832:
1830:
1828:
1814:
1808:
1807:
1805:
1803:
1784:
1778:
1777:
1775:
1773:
1745:
1739:
1738:
1736:
1734:
1712:
1701:
1700:
1698:
1696:
1677:
1650:
1649:
1632:
1626:
1625:
1589:
1572:
1571:
1569:
1567:
1552:
1546:
1545:
1543:
1541:
1527:
1521:
1520:
1518:
1516:
1502:
1483:
1482:
1480:
1478:
1461:
1455:
1454:
1452:
1450:
1440:nctr-crs.fda.gov
1432:
1426:
1425:
1419:
1268:Pharmacokinetics
1213:does not approve
1209:does not approve
1071:Pharmacokinetics
1031:arachidonic acid
997:taste perversion
981:gastrointestinal
972:Gastrointestinal
961:high cholesterol
890:gastrointestinal
873:
849:cyclooxygenase-1
845:cyclooxygenase-2
795:
794:
787:
729:
709:
694:
688:
682:
676:
670:
653:
642:
631:
630:
616:
614:
598:
592:
571:
551:
531:
511:
491:
471:
451:
431:
421:
420:
406:
335:
271:
268:
263:
256:
253:
243:
240:
232:
229:
219:
216:
194:
184:
137:
134:
116:
105:
102:
89:
75:
42:
33:
26:
24:
20:
4616:
4615:
4611:
4610:
4609:
4607:
4606:
4605:
4576:Dog medications
4571:Cat medications
4546:
4545:
4544:
4534:
4532:
4524:
4522:
4517:
4479:
4472:withdrawn drugs
4456:
4414:
4408:
4327:
4253:
4245:
4241:Tolfenamic acid
4199:Flufenamic acid
4167:
4158:
4002:
3994:
3939:
3795:
3786:
3696:
3665:Oxyphenbutazone
3595:
3586:
3568:
3538:
3537:
3527:
3525:
3516:
3515:
3511:
3501:
3499:
3492:
3474:
3470:
3460:
3458:
3454:
3444:Chemistry Today
3439:
3433:
3426:
3419:
3397:
3393:
3383:
3381:
3377:
3366:
3362:
3361:
3357:
3347:
3345:
3341:
3330:
3326:
3325:
3321:
3316:Wayback Machine
3305:Wayback Machine
3295:
3291:
3281:
3279:
3275:
3264:
3260:
3259:
3255:
3245:
3243:
3239:
3228:
3224:
3223:
3219:
3203:
3192:
3188:
3187:
3183:
3173:
3171:
3170:on 6 April 2017
3167:
3156:
3152:
3151:
3147:
3110:
3106:
3075:
3066:
3013:
3009:
2999:
2997:
2993:
2982:
2976:
2972:
2962:
2960:
2955:. 1 June 2006.
2947:
2946:
2942:
2897:
2893:
2883:
2881:
2877:
2876:
2872:
2862:
2860:
2852:
2851:
2844:
2831:
2830:
2826:
2816:
2814:
2805:
2804:
2800:
2785:
2781:
2766:
2762:
2747:
2743:
2696:
2692:
2653:(10): 980–984.
2639:
2635:
2604:
2600:
2594:Wayback Machine
2584:
2580:
2574:Wayback Machine
2563:Wayback Machine
2553:
2549:
2539:
2537:
2529:
2528:
2524:
2514:
2512:
2504:
2503:
2496:
2456:
2449:
2439:
2437:
2428:
2427:
2423:
2376:
2369:
2329:
2325:
2315:
2313:
2304:
2303:
2296:
2286:
2284:
2271:
2270:
2266:
2256:
2254:
2241:
2240:
2236:
2205:
2201:
2194:
2156:
2149:
2109:
2105:
2074:
2070:
2058:
2050:
2048:
2039:
2038:
2031:
2019:
2011:
2009:
1996:
1995:
1988:
1951:
1947:
1910:
1906:
1869:
1862:
1852:
1850:
1841:
1840:
1836:
1826:
1824:
1816:
1815:
1811:
1801:
1799:
1786:
1785:
1781:
1771:
1769:
1762:
1746:
1742:
1732:
1730:
1714:
1713:
1704:
1694:
1692:
1679:
1678:
1653:
1646:
1634:
1633:
1629:
1590:
1575:
1565:
1563:
1554:
1553:
1549:
1539:
1537:
1529:
1528:
1524:
1514:
1512:
1504:
1503:
1486:
1476:
1474:
1473:. 3 August 2022
1463:
1462:
1458:
1448:
1446:
1434:
1433:
1429:
1420:
1416:
1411:
1399:
1390:
1388:Other countries
1371:musculoskeletal
1359:
1317:
1312:
1304:bioavailability
1281:
1270:
1193:
1151:
1139:
1130:
1110:
1098:
1082:bioavailability
1078:
1073:
1038:
1035:prostaglandin H
1019:
1013:
993:
974:
926:
886:
880:
878:Adverse effects
871:
790:
788:
785:(what is this?)
782:
777:
774:
769:
764:
763:
752:
749:
744:
743:
732:
707:
697:
691:
685:
679:
673:
634:
610:
602:
574:
554:
534:
514:
494:
474:
454:
434:
417:
409:
389:
386:
373:
372:
333:
301:Protein binding
291:Bioavailability
283:Pharmacokinetic
277:
261:
198:
152:
145:
126:
119:
17:
12:
11:
5:
4614:
4604:
4603:
4598:
4593:
4588:
4583:
4578:
4573:
4568:
4563:
4558:
4556:Benzothiazines
4543:
4542:
4519:
4518:
4516:
4515:
4505:
4495:
4484:
4481:
4480:
4476:veterinary use
4461:
4458:
4457:
4455:
4454:
4449:
4444:
4439:
4434:
4429:
4424:
4418:
4416:
4410:
4409:
4407:
4406:
4401:
4396:
4391:
4386:
4381:
4376:
4371:
4366:
4361:
4356:
4351:
4346:
4341:
4335:
4333:
4329:
4328:
4326:
4325:
4320:
4315:
4310:
4305:
4300:
4295:
4290:
4285:
4280:
4275:
4263:
4257:
4255:
4247:
4246:
4244:
4243:
4238:
4233:
4228:
4225:Mefenamic acid
4221:
4216:
4211:
4206:
4201:
4196:
4191:
4186:
4181:
4175:
4173:
4160:
4159:
4157:
4156:
4145:
4140:
4135:
4130:
4125:
4120:
4115:
4110:
4105:
4100:
4095:
4088:
4083:
4078:
4073:
4068:
4063:
4056:
4051:
4046:
4041:
4036:
4031:
4026:
4021:
4016:
4010:
4008:
4000:propionic acid
3996:
3995:
3993:
3992:
3987:
3982:
3975:
3970:
3965:
3960:
3955:
3949:
3947:
3941:
3940:
3938:
3937:
3932:
3927:
3922:
3917:
3912:
3907:
3902:
3897:
3892:
3887:
3882:
3877:
3872:
3867:
3865:Fenclozic acid
3862:
3857:
3852:
3847:
3840:
3835:
3830:
3825:
3820:
3815:
3810:
3805:
3799:
3797:
3788:
3787:
3785:
3784:
3779:
3774:
3769:
3764:
3759:
3754:
3749:
3744:
3739:
3734:
3729:
3724:
3719:
3714:
3706:
3704:
3698:
3697:
3695:
3694:
3689:
3687:Sulfinpyrazone
3684:
3682:Propyphenazone
3679:
3676:Phenylbutazone
3672:
3667:
3662:
3657:
3652:
3647:
3642:
3637:
3632:
3627:
3622:
3617:
3612:
3607:
3605:Aminophenazone
3601:
3599:
3588:
3587:
3567:
3566:
3559:
3552:
3544:
3536:
3535:
3509:
3490:
3468:
3424:
3417:
3391:
3355:
3319:
3289:
3253:
3217:
3181:
3145:
3104:
3064:
3027:(2): 138–148.
3007:
2970:
2940:
2911:(5): 189–193.
2891:
2870:
2842:
2824:
2813:. 31 July 2006
2798:
2779:
2760:
2741:
2690:
2633:
2598:
2578:
2547:
2522:
2494:
2467:(4): 674–694.
2447:
2421:
2390:(4): 450–457.
2367:
2340:(10): 423–33.
2323:
2294:
2264:
2234:
2215:(2): 100–106.
2199:
2147:
2120:(4): 316–331.
2103:
2084:(2): 193–195.
2068:
2047:. 21 July 2017
2029:
1986:
1945:
1904:
1860:
1834:
1809:
1779:
1760:
1740:
1702:
1651:
1644:
1627:
1573:
1556:"Loxitab EPAR"
1547:
1522:
1484:
1456:
1427:
1413:
1412:
1410:
1407:
1406:
1405:
1398:
1395:
1389:
1386:
1358:
1357:European Union
1355:
1321:osteoarthritis
1316:
1313:
1311:
1308:
1279:
1269:
1266:
1192:
1189:
1150:
1149:Veterinary use
1147:
1138:
1135:
1129:
1126:
1109:
1106:
1097:
1094:
1077:
1074:
1072:
1069:
1061:synovial fluid
1042:prostaglandins
1036:
1023:cyclooxygenase
1015:Main article:
1012:
1009:
992:
989:
973:
970:
950:thromboembolic
925:
924:Cardiovascular
922:
879:
876:
837:stomach ulcers
818:osteoarthritis
797:
796:
779:
778:
776:
775:
772:
770:
767:
759:
758:
757:
754:
753:
751:
750:
747:
739:
738:
737:
734:
733:
731:
730:
722:
720:
712:
711:
705:
699:
698:
695:
689:
683:
677:
671:
666:
660:
659:
655:
654:
644:
636:
635:
633:
632:
619:
617:
604:
603:
601:
600:
584:
582:
576:
575:
573:
572:
564:
562:
556:
555:
553:
552:
544:
542:
536:
535:
533:
532:
524:
522:
516:
515:
513:
512:
504:
502:
496:
495:
493:
492:
484:
482:
476:
475:
473:
472:
464:
462:
456:
455:
453:
452:
444:
442:
436:
435:
433:
432:
424:
422:
411:
410:
408:
407:
399:
397:
391:
390:
388:
387:
376:
368:
367:
366:
363:
362:
358:
357:
347:
341:
340:
337:
328:
327:
313:
307:
306:
303:
297:
296:
293:
287:
286:
279:
278:
276:
275:
266:
251:
238:
227:
213:
211:
205:
204:
200:
199:
197:
196:
173:
171:
165:
164:
155:
153:administration
147:
146:
144:
143:
141:
131:
129:
121:
120:
118:
117:
99:
97:
91:
90:
83:
77:
76:
69:
59:
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35:
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9:
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3:
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4579:
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4453:
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4433:
4430:
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4402:
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4387:
4385:
4382:
4380:
4377:
4375:
4372:
4370:
4367:
4365:
4362:
4360:
4359:Fluproquazone
4357:
4355:
4352:
4350:
4347:
4345:
4342:
4340:
4337:
4336:
4334:
4330:
4324:
4321:
4319:
4316:
4314:
4311:
4309:
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4304:
4301:
4299:
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4291:
4289:
4286:
4284:
4281:
4279:
4276:
4273:
4269:
4268:
4264:
4262:
4259:
4258:
4256:
4252:
4248:
4242:
4239:
4237:
4236:Niflumic acid
4234:
4232:
4229:
4227:
4226:
4222:
4220:
4217:
4215:
4212:
4210:
4207:
4205:
4202:
4200:
4197:
4195:
4192:
4190:
4187:
4185:
4182:
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4094:
4093:
4089:
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4082:
4079:
4077:
4074:
4072:
4069:
4067:
4064:
4062:
4061:
4057:
4055:
4052:
4050:
4049:Flunoxaprofen
4047:
4045:
4042:
4040:
4037:
4035:
4034:Dexketoprofen
4032:
4030:
4027:
4025:
4022:
4020:
4017:
4015:
4012:
4011:
4009:
4006:
4003:derivatives (
4001:
3997:
3991:
3988:
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3976:
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3969:
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3916:
3915:Proglumetacin
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3911:
3910:Prodolic acid
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3893:
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3883:
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3850:Difenpiramide
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2065:
2064:public domain
2046:
2042:
2036:
2034:
2026:
2025:public domain
2007:
2005:
1999:
1993:
1991:
1982:
1978:
1973:
1968:
1964:
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1956:
1949:
1941:
1937:
1932:
1927:
1924:(9): 946–51.
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1900:
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1883:(9): 937–45.
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1272:In dogs, the
1265:
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1159:off-label use
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1086:bioequivalent
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829:heart disease
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641:ECHA InfoCard
637:
629:
625:
624:DTXSID1020803
621:
620:
618:
609:
605:
597:
596:RCSB PDB
591:
586:
585:
583:
581:
577:
570:
566:
565:
563:
561:
557:
550:
546:
545:
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537:
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526:
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521:
517:
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506:
505:
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490:
486:
485:
483:
481:
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470:
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465:
463:
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457:
450:
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437:
430:
426:
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423:
416:
412:
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401:
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396:
392:
384:
380:
375:
374:
371:
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359:
355:
351:
348:
346:
342:
338:
336:
329:
325:
321:
317:
314:
312:
308:
304:
302:
298:
294:
292:
288:
284:
280:
274: Rx-only
267:
264:
252:
249:
239:
237:
228:
225:
215:
214:
212:
210:
206:
201:
193:
188:
183:
178:
175:
174:
172:
170:
166:
163:
159:
156:
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148:
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132:
130:
128:
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110:
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92:
88:
84:
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60:
57:Mobic, others
56:
54:
50:
47:Clinical data
45:
41:
36:
32:
27:
19:
4566:Carboxamides
4463:
4415:combinations
4265:
4231:Morniflumate
4223:
4194:Floctafenine
4179:Azapropazone
4163:
4147:
4123:Tarenflurbil
4108:Piketoprofen
4103:Pelubiprofen
4090:
4058:
4054:Flurbiprofen
4029:Dexibuprofen
4019:Benoxaprofen
4014:Alminoprofen
3977:
3972:
3842:
3772:Salicylamide
3709:
3674:
3650:Mofebutazone
3630:Famprofazone
3625:Difenamizole
3615:Azapropazone
3526:. Retrieved
3521:
3512:
3500:. Retrieved
3481:
3471:
3459:. Retrieved
3447:
3443:
3402:
3394:
3382:. Retrieved
3358:
3346:. Retrieved
3339:the original
3322:
3292:
3280:. Retrieved
3273:the original
3256:
3244:. Retrieved
3237:the original
3220:
3207:
3201:the original
3184:
3172:. Retrieved
3165:the original
3148:
3121:
3117:
3107:
3082:
3078:
3024:
3020:
3010:
2998:. Retrieved
2986:
2973:
2963:16 September
2961:. Retrieved
2952:
2943:
2908:
2904:
2894:
2882:. Retrieved
2873:
2861:. Retrieved
2857:
2836:
2827:
2815:. Retrieved
2810:
2801:
2792:
2782:
2773:
2763:
2754:
2744:
2707:
2704:PLOS Biology
2703:
2693:
2650:
2646:
2636:
2611:
2607:
2601:
2581:
2550:
2538:. Retrieved
2534:
2525:
2513:. Retrieved
2509:
2464:
2460:
2438:. Retrieved
2424:
2387:
2383:
2337:
2333:
2326:
2314:. Retrieved
2285:. Retrieved
2267:
2255:. Retrieved
2237:
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2049:. Retrieved
2044:
2010:. Retrieved
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1948:
1921:
1917:
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1880:
1876:
1851:. Retrieved
1846:
1837:
1825:. Retrieved
1821:
1812:
1800:. Retrieved
1791:
1782:
1770:. Retrieved
1750:
1743:
1731:. Retrieved
1719:
1693:. Retrieved
1684:
1635:
1630:
1597:
1593:
1564:. Retrieved
1559:
1550:
1538:. Retrieved
1534:
1525:
1513:. Retrieved
1509:
1475:. Retrieved
1468:
1459:
1447:. Retrieved
1439:
1430:
1417:
1391:
1380:. The first
1375:
1367:chronic pain
1360:
1348:
1345:
1341:
1318:
1310:Legal status
1295:
1289:
1271:
1249:
1243:
1239:
1236:
1228:
1216:
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1208:
1204:
1198:
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1096:Distribution
1079:
1058:
1020:
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975:
957:hypertension
955:People with
954:
934:heart attack
927:
910:
887:
861:
843:. It blocks
826:
805:
801:
800:
789:
783:
382:
378:
332:Elimination
209:Legal status
203:Legal status
95:License data
18:
4364:Glucosamine
4344:Benzydamine
4313:Robenacoxib
4298:Lumiracoxib
4189:Etofenamate
4154:Naproxcinod
4143:Zaltoprofen
3953:Ampiroxicam
3875:Indometacin
3803:Aceclofenac
3794:derivatives
3792:acetic acid
3742:Ethenzamide
3737:Dipyrocetyl
3702:salicylates
3592:pyrazolones
3384:21 February
2989:: 340–342.
2614:(1): 62–9.
2287:15 November
2273:"Meloxicam"
2257:15 November
2247:MedlinePlus
2243:"Meloxicam"
1733:20 February
1695:23 December
1373:disorders.
1262:proteinuria
1025:(COX), the
942:thromboxane
928:Like other
710: g·mol
647:100.113.257
361:Identifiers
162:intravenous
81:MedlinePlus
53:Trade names
4550:Categories
4394:Proquazone
4384:Nimesulide
4379:Nabumetone
4374:Hyperforin
4323:Valdecoxib
4288:Etoricoxib
4138:Vedaprofen
4086:Miroprofen
4081:Loxoprofen
4076:Ketoprofen
4071:Indoprofen
4044:Fenoprofen
3968:Lornoxicam
3905:Oxametacin
3844:Diclofenac
3838:Bumadizone
3813:Alclofenac
3808:Acemetacin
3747:Guacetisal
3732:Diflunisal
3722:Benorylate
3692:Suxibuzone
3660:Nifenazone
3645:Metamizole
3502:28 January
3461:28 January
3450:(2): 4–6.
2710:(3): e66.
2051:15 October
2012:15 October
1721:Baudax Bio
1449:22 October
1409:References
1351:Baudax Bio
1333:injectable
1274:absorption
1177:diclofenac
1166:ulceration
1122:Peroxidase
1108:Metabolism
1076:Absorption
985:ulceration
917:drug label
898:diclofenac
882:See also:
715:3D model (
703:Molar mass
580:PDB ligand
549:CHEBI:6741
509:VG2QF83CGL
480:ChemSpider
440:IUPHAR/BPS
404:71125-38-7
395:CAS Number
370:IUPAC name
326:-mediated)
311:Metabolism
4591:Thiazoles
4464:underline
4389:Oxaceprol
4354:Diacerein
4318:Rofecoxib
4308:Parecoxib
4303:Mavacoxib
4293:Firocoxib
4283:Deracoxib
4278:Cimicoxib
4272:+tramadol
4267:Celecoxib
4261:Apricoxib
4214:Glafenine
4209:Flutiazin
4170:fenamates
4128:Tepoxalin
4113:Pirprofen
4098:Oxaprozin
4066:Ibuproxam
4060:Ibuprofen
4024:Carprofen
3990:Tenoxicam
3985:Pivoxicam
3979:Piroxicam
3973:Meloxicam
3935:Zomepirac
3900:Mofezolac
3895:Lonazolac
3890:Ketorolac
3870:Fentiazac
3833:Bufexamac
3828:Bromfenac
3762:Salsalate
3717:Aloxiprin
3670:Phenazone
3635:Feprazone
3620:Clofezone
3059:220256059
2277:Drugs.com
2142:205715393
1853:8 October
1827:30 August
1802:30 August
1685:Drugs.com
1622:260452199
1285:half-life
1128:Excretion
1005:dry mouth
902:piroxicam
857:piroxicam
802:Meloxicam
569:ChEMBL599
345:Excretion
334:half-life
151:Routes of
125:Pregnancy
114:Meloxicam
73:Monograph
67:Drugs.com
23:Meloxicam
4540:Medicine
4493:category
4254:(coxibs)
4204:Flunixin
4184:Clonixin
4118:Suprofen
4092:Naproxen
4039:Fenbufen
3963:Isoxicam
3958:Droxicam
3930:Tolmetin
3925:Tiopinac
3920:Sulindac
3885:Isoxepac
3860:Felbinac
3855:Etodolac
3823:Bendazac
3655:Morazone
3640:Kebuzone
3610:Ampyrone
3528:29 March
3496:Archived
3452:Archived
3375:Archived
3348:8 August
3312:Archived
3301:Archived
3282:8 August
3246:8 August
3140:23406022
3099:22381180
3051:32594827
3042:10741344
3000:9 August
2991:Archived
2957:Archived
2935:29109603
2884:29 March
2863:29 March
2817:29 March
2736:16435886
2685:30649716
2677:29165006
2668:11129237
2628:16412133
2590:Archived
2570:Archived
2559:Archived
2535:DailyMed
2510:DailyMed
2489:59338182
2481:30693946
2440:6 August
2434:Archived
2416:30774225
2362:37937305
2316:17 March
2310:Archived
2281:Archived
2251:Archived
2229:15234645
2188:25512189
2180:16197363
2134:22931375
1847:DailyMed
1822:ClinCalc
1796:Archived
1792:ClinCalc
1766:Archived
1727:Archived
1689:Archived
1687:. AHFS.
1535:DailyMed
1510:DailyMed
1477:25 March
1397:See also
1323:, as an
1185:vultures
1090:antacids
965:diabetes
946:platelet
906:naproxen
792:(verify)
489:10442740
460:DrugBank
339:20 hours
169:ATC code
158:By mouth
127:category
109:DailyMed
4601:Sultams
4503:commons
4404:Tenidap
4168:acids (
4005:profens
3945:oxicams
3818:Amfenac
3767:Salicin
3581:, also
3524:. DEFRA
3369:. U.S.
3333:. U.S.
3267:. U.S.
3231:. U.S.
3174:24 July
2926:5662437
2727:1351921
2407:6360894
2354:8564518
1981:8630632
1940:9783758
1899:9783757
1772:30 June
1614:8882380
1382:generic
1290:In the
1179:by the
1102:albumin
664:Formula
469:DB00814
429:5281106
415:PubChem
356:equally
265:Rx-only
262:WARNING
234::
189: (
187:M01AC56
185:)
179: (
177:M01AC06
140: C
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87:a601242
4526:Portal
4513:portal
3488:
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3039:
2953:Dvm360
2933:
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2724:
2683:
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2665:
2626:
2540:15 May
2515:15 May
2487:
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2404:
2360:
2352:
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2178:
2140:
2132:
2096:
1979:
1938:
1897:
1758:
1723:, Inc.
1642:
1620:
1612:
1566:24 May
1540:15 May
1515:15 May
1329:liquid
1231:NSAIDs
1118:CYP3A4
1114:CYP2C9
1065:plasma
1027:enzyme
977:NSAIDs
938:stroke
930:NSAIDs
872:
853:oxicam
833:stroke
741:SMILES
708:351.40
560:ChEMBL
529:D00969
320:CYP2C9
259:
246:
236:â„ž-only
222:
107:
4462:Key:
4413:NSAID
4332:other
3583:N02BA
3455:(PDF)
3440:(PDF)
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3367:(PDF)
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3276:(PDF)
3265:(PDF)
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3229:(PDF)
3204:(PDF)
3193:(PDF)
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3157:(PDF)
3055:S2CID
2994:(PDF)
2983:(PDF)
2681:S2CID
2485:S2CID
2358:S2CID
2184:S2CID
2138:S2CID
2006:(FDA)
2002:U.S.
1618:S2CID
1594:Drugs
1363:acute
1292:koala
1222:death
1054:COX-1
1052:over
1050:COX-2
1033:into
991:Mouth
963:, or
806:Mobic
761:InChI
717:JSmol
587:MXM (
540:ChEBI
354:feces
350:Urine
316:Liver
305:99.4%
3579:M02A
3577:and
3575:M01A
3530:2023
3504:2020
3486:ISBN
3463:2020
3413:ISBN
3386:2020
3350:2019
3284:2019
3248:2019
3176:2010
3136:PMID
3095:PMID
3047:PMID
3002:2019
2965:2018
2931:PMID
2886:2024
2865:2024
2819:2024
2732:PMID
2673:PMID
2624:PMID
2542:2021
2517:2021
2477:PMID
2442:2019
2412:PMID
2350:PMID
2318:2010
2289:2014
2259:2014
2225:PMID
2176:PMID
2130:PMID
2098:2012
2094:PMID
2053:2020
2014:2020
1977:PMID
1936:PMID
1895:PMID
1855:2022
1829:2024
1804:2024
1774:2020
1756:ISBN
1735:2020
1697:2018
1640:ISBN
1610:PMID
1568:2024
1542:2021
1517:2021
1479:2024
1451:2023
1365:and
1325:oral
1255:and
1220:and
1199:The
1116:and
1080:The
1003:and
936:and
816:and
590:PDBe
520:KEGG
500:UNII
449:7220
352:and
322:and
285:data
63:AHFS
3409:301
3298:FAQ
3126:doi
3087:doi
3037:PMC
3029:doi
2921:PMC
2913:doi
2793:FDA
2774:FDA
2755:FDA
2722:PMC
2712:doi
2663:PMC
2655:doi
2616:doi
2469:doi
2402:PMC
2392:doi
2342:doi
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1967:doi
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1168:).
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