1028:
110:
than those genes expressed exclusively in the diploid stage is referred to as the “masking theory”. This theory implies that purifying selection is more efficient in the haploid stage of the life cycle where fitness effects are more fully expressed than in the diploid stage of the life cycle.
72:
variation, producing a decrease in the level of variation surrounding the locus under selection. The incidental purging of non-deleterious alleles due to such spatial proximity to deleterious alleles is called
65:
being the unit of selection. In such a case, carriers of the harmful point mutation have fewer offspring each generation, reducing the frequency of the mutation in the gene pool.
757:
117:. Further evidence of strong purifying selection in haploid tissue-specific genes, in support of the masking theory, has been reported for the plant,
90:. Purging by genetic drift can remove primarily deeply recessive alleles, whereas natural selection can remove any type of deleterious alleles.
714:
554:
501:
Gerstein AC, Cleathero LA, Mandegar MA, Otto SP (March 2011). "Haploids adapt faster than diploids across a range of environments".
68:
In the case of strong negative selection on a locus, the purging of deleterious variants will result in the occasional removal of
1069:
1007:
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20:
707:
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547:
802:
1043:
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170:
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454:"Strong Purifying Selection in Haploid Tissue-Specific Genes of Scots Pine Supports the Masking Theory"
903:
777:
196:
955:
113:
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79:. This effect increases with lower mutation rate but decreases with higher recombination rate.
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51:
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Cervantes S, Kesälahti R, Kumpula TA, Mattila TM, Helanterä H, Pyhäjärvi T (August 2023).
8:
984:
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43:
27:
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Evidence supporting the masking theory has been reported in the single-celled yeast
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989:
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220:"Inbreeding depression and purging in a haplodiploid: gender-related effects"
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288:
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93:
394:
345:
635:
235:
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Gulisija D, Crow JF (May 2007). "Inferring purging from pedigree data".
692:
532:
950:
410:"How are deleterious mutations purged? Drift versus nonrandom mating"
150:
312:"The effect of deleterious mutations on neutral molecular variation"
82:
Purifying selection can be split into purging by non-random mating (
1035:
1027:
39:
451:
103:
309:
500:
99:
310:
Charlesworth B, Morgan MT, Charlesworth D (August 1993).
94:
Negative selection in haploid compared to diploid tissue
57:
Purging of deleterious alleles can be achieved on the
414:
Evolution; International
Journal of Organic Evolution
361:"Deleterious background selection with recombination"
269:
Evolution; International
Journal of Organic Evolution
16:Selective removal of alleles that are deleterious
1080:
447:
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1063:
708:
548:
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358:
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1070:
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715:
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218:Tien NS, Sabelis MW, Egas M (March 2015).
477:
425:
384:
335:
243:
102:of an organism that are expressed in the
722:
562:
1081:
1008:Index of evolutionary biology articles
407:
359:Hudson RR, Kaplan NL (December 1995).
696:
536:
194:
54:that arise through random mutations.
1022:
50:through the purging of deleterious
21:Negative selection (disambiguation)
13:
427:10.1111/j.0014-3820.2003.tb01512.x
61:level, with as little as a single
14:
1115:
626:Models of nucleotide substitution
1026:
515:10.1111/j.1420-9101.2010.02188.x
281:10.1111/j.1558-5646.2007.00088.x
106:stage are under more efficient
808:Constructive neutral evolution
494:
401:
352:
303:
188:
1:
181:
1042:. You can help Knowledge by
758:Fisher's fundamental theorem
38:is the selective removal of
7:
783:Coefficient of relationship
377:10.1093/genetics/141.4.1605
328:10.1093/genetics/134.4.1289
124:
10:
1120:
1021:
682:Nonsynonymous substitution
408:Glémin S (December 2003).
171:Mutation–selection balance
18:
1003:
938:
912:
874:
849:
816:
778:Coefficient of inbreeding
730:
654:
613:
570:
956:Evolutionary game theory
738:Hardy–Weinberg principle
114:Saccharomyces cerevisiae
768:Shifting balance theory
677:Synonymous substitution
621:Models of DNA evolution
753:Linkage disequilibrium
470:10.1093/molbev/msad183
995:Quantitative genetics
904:Balding–Nichols model
889:Population bottleneck
884:Small population size
788:Selection coefficient
600:Stabilizing selection
585:Directional selection
176:Stabilizing selection
156:Fluctuating selection
141:Directional selection
52:genetic polymorphisms
48:stabilising selection
46:. This can result in
866:Background selection
853:on genomic variation
851:Effects of selection
803:Population structure
590:Disruptive selection
236:10.1038/hdy.2014.106
197:"Negative selection"
146:Disruptive selection
98:The idea that those
76:background selection
19:For other uses, see
1099:Population genetics
985:Population genomics
861:Genetic hitchhiking
748:Identity by descent
724:Population genetics
655:Molecular processes
580:Balancing selection
564:Molecular evolution
136:Balancing selection
59:population genetics
36:purifying selection
1094:Classical genetics
971:Landscape genetics
595:Negative selection
131:Assortative mating
84:assortative mating
32:negative selection
1051:
1050:
1016:
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966:Genetic genealogy
961:Fitness landscape
690:
689:
572:Natural selection
108:natural selection
86:) and purging by
28:natural selection
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925:J. B. S. Haldane
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667:Gene duplication
631:Allele frequency
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662:Gene conversion
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605:Selective sweep
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420:(12): 2678–87.
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322:(4): 1289–303.
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161:Genetic purging
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763:Neutral theory
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371:(4): 1605–17.
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63:point mutation
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1038:article is a
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876:Genetic drift
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509:(3): 531–40.
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458:Mol Biol Evol
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230:(3): 327–32.
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88:genetic drift
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1044:expanding it
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946:Biogeography
920:R. A. Fisher
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798:Heritability
731:Key concepts
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31:
25:
899:Coalescence
636:Ka/Ks ratio
503:J Evol Biol
166:Koinophilia
44:deleterious
1083:Categories
841:Ecological
831:Artificial
641:Tajima's D
182:References
119:Scots Pine
1089:Selection
951:Evolution
818:Selection
151:Dysgenics
42:that are
1036:genetics
975:genomics
913:Founders
523:21159002
488:37565532
479:10457172
436:14761049
365:Genetics
316:Genetics
297:24302475
289:17492959
254:25407077
224:Heredity
207:(1): 59.
125:See also
826:Natural
793:Fitness
395:8601498
386:1206891
346:8375663
337:1205596
245:4815584
104:haploid
40:alleles
836:Sexual
614:Models
521:
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70:linked
1034:This
464:(8).
293:S2CID
100:genes
1040:stub
973:and
519:PMID
484:PMID
432:PMID
391:PMID
342:PMID
285:PMID
250:PMID
511:doi
474:PMC
466:doi
422:doi
381:PMC
373:doi
369:141
332:PMC
324:doi
320:134
277:doi
240:PMC
232:doi
228:114
34:or
26:In
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517:.
507:24
505:.
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444:^
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30:,
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23:.
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