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cortex) very little rough endoplasmic reticulum is present. The pattern of coloration with Nissl stains once was used to classify neurons. For various reasons, this practice has largely ceased, but specific neuronal types do manifest characteristic types of Nissl bodies.
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129:). The term "Nissl bodies" generally refers to discrete clumps of rough endoplasmic reticulum and free ribosomes in nerve cells. Masses of rough endoplasmic reticulum also occur in some non-neuronal cells, where they are referred to as
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bodies, or chromophilic substance. While these organelles differ in some ways from Nissl bodies in neurons, large amounts of rough endoplasmic reticulum are generally linked to the copious production of proteins.
215:
The functions of Nissl bodies are thought to be the same as those of the rough endoplasmic reticulum in general, primarily the synthesis and segregation of proteins. Similar to the ergastoplasm of
162:("base-loving"). The dense accumulation of membrane-bound and free ribosomes in Nissl bodies results in their intense coloration by Nissl stains, allowing them to be seen with a light
69:
Drawing of a motor neuron from the ventral horn of the medulla spinals of a rabbit. The angular and spindle-shaped Nissl bodies in the cytoplasm are well shown.
247:). If the neuron is successful in repairing the damage, the Nissl bodies gradually reappear and return to their characteristic distribution within the cell.
535: – Histology Learning System at Boston University - "Nervous Tissue and Neuromuscular Junction: spinal cord, cell bodies of anterior horn cells"
202:, where they appear as large, blocky assemblies. In other neurons, they may be smaller, and in some (such as the granule neurons of the
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337:"Franz Nissl (1860-1919), noted neuropsychiatrist and neuropathologist, staining the neuron, but not limiting it"
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of Nissl bodies suggests they are primarily concerned with the synthesis of proteins for intracellular use.
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146:"Nissl stains" refers to various basic dyes that selectively label negatively charged molecules such as
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190:. They vary in size, shape, and intracellular location; they are most conspicuous in the
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cells, Nissl bodies are the main site of protein synthesis in the neuronal
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Nissl bodies show changes under various physiological conditions and in
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Brain Damage and Repair: From
Molecular Research to Clinical Therapy
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Color Atlas of
Cytology, Histology, and Microscopic Anatomy
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243:, during which they may dissolve and largely disappear (
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surface of the membranes. Nissl bodies were named after
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27:
Rough endoplasmic reticulum structure found in neurons
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of Nissl bodies (two are indicated by arrows) in the
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544:Tissues containing Nissl bodies at harvard.edu
473:T. Herdegen; J. Delgado-Garcia (25 May 2005).
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41:of motor neurons in the anterior horn of the
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273:Junqueira LC, Carniero J, Kelley RO (1995).
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101:, a collection of parallel, membrane-bound
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525:at the U.S. National Library of Medicine
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416:The Fine Structure of the Nervous System
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169:
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414:Peters A, Palay SL, Webster Hd (1991).
378:The Cell: Its Organelles and Inclusions
375:
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93:) are discrete granular structures in
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301:Richard H. Thompson (29 March 2000).
24:
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25:
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353:10.1590/1980-57642018dn13-030014
304:The Brain: A Neuroscience Primer
154:. Because ribosomes are rich in
735:Oligodendrocyte progenitor cell
341:Dementia & Neuropsychologia
182:of neurons, though not in the
13:
1:
250:
539:Histology at anhb.uwa.edu.au
230:
49:stain (purple) along with a
7:
845:Postganglionic nerve fibers
418:. Oxford University Press.
307:. Macmillan. pp. 35–.
141:
10:
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840:Preganglionic nerve fibers
479:. Springer. pp. 37–.
174:Nissl bodies occur in the
1350:Olfactory receptor neuron
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1014:Neurofibril/neurofilament
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533:Histology image: 04103loa
445:. Thieme. pp. 182–.
380:. W.B. Saunders Company.
125:method bearing his name (
527:Medical Subject Headings
439:Wolfgang Kühnel (2003).
376:Fawcett, Don W. (1966).
335:Da Mota Gomes M (2019).
277:. Appleton & Lange.
1297:Neuromuscular junction
1160:III or Aδ or fast pain
97:that consist of rough
70:
62:
170:Size and distribution
99:endoplasmic reticulum
75:cellular neuroscience
68:
33:
1390:Nervous tissue cells
1315:Meissner's corpuscle
1280:Postsynaptic density
1177:Efferent nerve fiber
1165:IV or C or slow pain
1107:Afferent nerve fiber
933:Satellite glial cell
519:at Wikimedia Commons
158:, they are strongly
1320:Merkel nerve ending
239:conditions such as
1355:Photoreceptor cell
1325:Pacinian corpuscle
1256:Electrical synapse
1210:Lower motor neuron
1205:Upper motor neuron
926:Internodal segment
866:Connective tissues
836:Autonomic ganglion
71:
63:
1377:
1376:
1373:
1372:
1340:Free nerve ending
1307:Sensory receptors
1235:
1234:
1150:Ib or Golgi or Aα
1058:
1057:
941:
940:
818:Ramus communicans
757:
756:
753:
752:
623:Commissural fiber
618:Association fiber
613:Projection fibers
515:Media related to
486:978-1-4020-1892-3
452:978-3-13-562404-4
314:978-0-7167-3226-6
121:who invented the
91:tigroid substance
57:. Scale bar = 30
16:(Redirected from
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1270:Synaptic vesicle
1265:Chemical synapse
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1044:Apical dendrite
1039:Dendritic spine
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921:Node of Ranvier
916:Myelin incisure
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740:Oligodendrocyte
723:Ependymal cells
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211:Functional role
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87:Nissl substance
51:luxol fast blue
35:Photomicrograph
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387:0-7216-3585-7
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245:chromatolysis
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192:motor neurons
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156:ribosomal RNA
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105:studded with
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81:(also called
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47:cresyl violet
44:
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19:
1260:Gap junction
1182:Motor neuron
1033:
976:Axon hillock
952:nerve fibers
906:Schwann cell
816:
799:
777:
695:Medium spiny
608:White matter
596:Tissue Types
523:Nissl+Bodies
490:. Retrieved
475:
468:
456:. Retrieved
441:
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415:
377:
371:
344:
340:
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318:. Retrieved
303:
274:
237:pathological
234:
214:
188:axon hillock
173:
145:
131:ergastoplasm
90:
86:
82:
79:Nissl bodies
78:
72:
1275:Active zone
1240:Termination
1090:Interneuron
994:Telodendron
902:Myelination
884:Endoneurium
879:Perineurium
700:Interneuron
690:Von Economo
638:Decussation
633:Nerve tract
603:Grey matter
517:Nissl stain
241:axonotmesis
196:spinal cord
117:, a German
115:Franz Nissl
43:spinal cord
1345:Nociceptor
1085:Multipolar
1034:Nissl body
911:Neurilemma
874:Epineurium
659:Cell Types
251:References
204:cerebellar
164:microscope
160:basophilic
135:basophilic
53:stain for
1360:Hair cell
894:Neuroglia
856:Funiculus
745:Microglia
718:Astrocyte
675:Pyramidal
628:Lemniscus
492:4 January
458:4 January
320:4 January
231:Pathology
221:cytoplasm
217:glandular
200:brainstem
180:dendrites
111:cytosolic
107:ribosomes
103:cisternae
61:(0.03mm).
39:cytoplasm
1384:Category
1145:Ia or Aα
1075:Unipolar
1024:Dendrite
1009:Axolemma
1004:Axoplasm
788:Ganglion
728:Tanycyte
680:Purkinje
667:Neuronal
650:Meninges
645:Neuropil
142:Staining
123:staining
1287:Autapse
1248:Synapse
1095:Renshaw
1070:Bipolar
947:Neurons
800:Ventral
771:General
685:Granule
362:6753910
194:of the
109:on the
95:neurons
59:microns
1140:fibers
778:Dorsal
529:(MeSH)
483:
449:
422:
384:
359:
311:
281:
223:. The
176:somata
55:myelin
1063:Types
960:Parts
829:White
810:Ramus
793:Ramus
710:Glial
986:Axon
968:Soma
824:Gray
805:Root
783:Root
494:2013
481:ISBN
460:2013
447:ISBN
420:ISBN
382:ISBN
322:2013
309:ISBN
279:ISBN
198:and
184:axon
178:and
150:and
1200:SVE
1195:GVE
1190:GSE
1135:SVA
1130:SSA
1125:GVA
1120:GSA
763:PNS
588:CNS
357:PMC
349:doi
186:or
152:RNA
148:DNA
89:or
73:In
1386::
904::
396:^
355:.
345:13
343:.
339:.
293:^
259:^
166:.
133:,
85:,
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847:)
838:(
572:e
565:t
558:v
496:.
462:.
428:.
390:.
365:.
351::
324:.
287:.
20:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
