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Paraquat

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1573:) which have been linked to PD and develop safer alternatives as per WHO guidance" and "accelerate action to reduce levels of and exposure to air pollution, an important risk factor for PD". A 2011 study showed a link between paraquat use and Parkinson's disease in farm workers. A co-author of the paper said that paraquat increases production of certain oxygen derivatives that may harm cellular structures, and that people who used paraquat, or other pesticides with a similar mechanism of action, were more likely to develop Parkinson's. A 2013 meta-analysis published in 299: 202: 553: 558: 548: 954: 34: 1045: 1106: 43: 3865: 3082: 1370:(EPA) determined that particles used in agricultural practices (400–800 μm) are not in the respirable range. Paraquat also causes moderate to severe irritation of the eye and skin. Diluted paraquat used for spraying is less toxic; thus, the greatest risk of accidental poisoning is during mixing and loading paraquat for use. 1314:
by farmers as a resistance management strategy. Nevertheless, herbicide resistance has been seen for both herbicides in a vineyard in Western Australia – though this singular report gives no indication of what regimen was being followed, particularly if the two herbicides were being used in a "double knock" tandem.
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In the UK, the use of paraquat was banned in 2007, but the manufacture and export of the herbicide is still permitted. In April of 2022, the BBC reported that some UK farmers had called for a ban on British production of paraquat, and stated that "There is no scientific consensus and many conflicting
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The European Union approved the use of paraquat in 2004 but Sweden, supported by Denmark, Austria, and Finland, appealed this decision. In 2007, the court annulled the directive authorizing paraquat as an active plant protection substance stating that the 2004 decision was wrong in finding that there
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Some pesticides, like rotenone, can directly block the function of mitochondria, the structures that create energy to run the cell. NIEHS researchers showed in mice that disrupting mitochondria through exposure to rotenone early in development changed the epigenome—the chemical tags that turn genes
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may also improve outcomes depending on the timing. Haemodialysis, haemofiltration, haemoperfusion, or antioxidant therapy may also be suggested. Immunosuppressive therapy to reduce the inflammation is an approach suggested by some, however only low certainty evidence supports using medications such
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One example is the "double knock" system used in Australia. Before planting a crop, weeds are sprayed with glyphosate first, then followed seven to ten days later by a paraquat herbicide. Although twice as expensive as using a single glyphosate spray, the "Double Knock" system is widely relied upon
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committed suicide using paraquat in 2007. Paraquat is widely used as a suicide agent in developing countries because it is widely available at low cost. Further, the toxic dose is low (10 mL or 2 teaspoons is enough to kill). Campaigns exist to control or even ban paraquat, and there are
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recommended to the Conference of the Parties (COP) paraquat dichloride formulations for inclusion in Annex III to the Convention in 2011. A small group of countries, including India and Guatemala and supported by manufacturers, have since blocked the listing of paraquat as a hazardous chemical for
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Lung injury is a main feature of poisoning. Liver, heart, lung, and kidney failure can occur within several days to weeks that can lead to death up to 30 days after ingestion. Those who suffer large exposures are unlikely to survive. Chronic exposure can lead to lung damage, kidney failure, heart
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found that "exposure to paraquat ... was associated with about a 2-fold increase in risk" of Parkinson's disease. A review in 2021 concluded that the available evidence does not support a causal conclusion. In 2022 and 2023, two reviews from India "decisively demonstrated that paraquat is a
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Accidental deaths and suicides from paraquat ingestion are relatively common. For example, there are more than 5,000 deaths in China from paraquat poisoning every year in part leading to China's ban in 2017. Long-term exposures to paraquat would most likely cause lung and eye damage, but
1056:, which means that it can be used by licensed applicators only. According to an October 2021 estimate, the use of paraquat in US agriculture as mapped by the US Geological Survey showed a doubling from 2013 to 2018, reaching 10,000,000 pounds (4,500,000 kg) annually. 1528:
moves to restrict its availability by requiring user education and the locking up of paraquat stores. When a 2011 South Korean law completely banned paraquat in the country, death by pesticide plummeted 46%, contributing to the decrease of the overall suicide rate.
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in addition to the standard care to reduce mortality. It is also unknown if adding glucocorticoid with cyclophosphamide to the standard care has unwanted side effects such as increasing the risk of infection. Oxygen should not be administered unless
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fields in Mexico. Following Mexican efforts to eradicate marijuana and poppy fields in 1975, the United States government helped by sending helicopters and other technological assistance. Helicopters were used to spray the herbicides paraquat and
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People with Parkinson's disease who are exposed to a high level of ten different active ingredients in agricultural pesticides may see their motor and non-motor symptoms progress faster compared with those who are not, a 2022 study
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Eubank, T. W.; Poston, D. H.; Nandula, V. K.; Koger, C. H.; Shaw, D. R.; Reynolds, D. B. (2008). "Glyphosate-resistant Horseweed (Conyza canadensis) Control Using Glyphosate-, Paraquat-, and Glufosinate-Based Herbicide Programs".
1294:(IWM) systems. Paraquat, with its distinctive mode of action, is one of few chemical options that can be used to prevent and mitigate problems with weeds that have become resistant to the very widely used non-selective herbicide 1466:
Whether any injury came about due to the inhalation of paraquat-contaminated marijuana is uncertain. A 1995 study found that "no lung or other injury in cannabis users has ever been attributed to paraquat contamination". Also a
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from 1979 to 2001, 70 percent of suicides were by paraquat poisoning. Trinidad and Tobago is particularly well known for its incidence of suicides involving the use of Gramoxone (commercial name of paraquat). In southern
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of the lung selectively concentrate paraquat. It has been reported that a small dose, even if removed from the stomach or spat out, can still cause death from fibrous tissue developing in the lungs, leading to
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In August 2024, the B.C. (British Columbia) Supreme Court certified a class-action lawsuit against Syngenta on behalf of at least two plaintiffs who were diagnosed with Parkinson's after exposure to paraquat.
1243:(ROS) are produced. In forming these reactive oxygen species, the oxidized form of paraquat is regenerated, and is again available to shunt electrons from photosystem I to restart the cycle. This induces 1059:
There is an ongoing international campaign for a global ban, but the cheap and popular paraquat continues to be unrestricted in most developing countries. The Chemical Review Committee (CRC) of the
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Using data from a NIEHS-conducted agricultural health study, researchers found that Parkinson's risk from paraquat use was particularly high in people with a particular variant of a gene known as
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Neve, P.; Diggle, A. J.; Smith, F. P.; Powles, S. B. (2003). "Simulating evolution of glyphosate resistance in Lolium rigidum II: Past, present and future glyphosate use in Australian cropping".
528: 2395: 1299: 1699:, could help reduce the incidence of the disease. For example, using protective gloves and other hygiene practices reduced the risk of Parkinson's disease among farmers using paraquat, 1594:
is ongoing; the company rejects the claims but has paid £187.5 million into a settlement fund. As of August 2024, more than 5,700 cases against Syngenta (manufacturer of Gramoxone) and
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Bockman, T. M.; Kochi, J. K. (1990). "Isolation and Oxidation-Reduction of Methylviologen Cation Radicals. Novel Disproportionation in Charge-Transfer Salts by X-Ray Crystallography".
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Bockman T. M.; Kochi J. K. (1990). "Isolation and oxidation-reduction of methylviologen cation radicals. Novel disproportionation in charge-transfer salts by X-ray crystallography".
1523:, particularly in Penal, Debe from 1996 to 1997, 76 percent of suicides were by paraquat, 96 percent of which involved the over-consumption of alcohol such as rum. Fashion celebrity 1226: 1169: 1831:
Michaelis, L. (1932). "Ein Reduktions-Indikator im Potentialbereich der Wasserstoffüberspannung" [A reduction indicator in the voltage range of hydrogen overpotential].
1535:, which occurred in Japan in 1985, were carried out using paraquat as a poison. Paraquat was used in the UK in 1981 by a woman who poisoned her husband. American serial killer 5313: 3765: 2415:
Wesseling, C., Corriols, M., Bravo, V., (2005), Acute pesticide poisoning and pesticide registration in Central America, Toxicology and Applied Pharmacology, 207, 697-705.
73:; Crisquat; Dexuron; Esgram; Gramuron; Ortho Paraquat CL; Para-col; Pillarxone; Tota-col; Toxer Total; PP148; Cyclone; Gramixel; Gramoxone; Pathclear; AH 501; Bai Cao Ku. 5015: 634: 1654:
Pesticides may directly or indirectly disrupt the biological pathways that normally protect dopaminergic neurons, the brain cells selectively attacked by the disease.
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Paraquat is classified as a non-selective contact herbicide. The key characteristics that distinguish it from other agents used in plant protection products are:
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showed that with alternating annual use between glyphosate and paraquat, only one field in five would be expected to have glyphosate-resistant annual ryegrass (
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Coats, G. E.; Funderburk, H. H. Jr.; Lawrence, J. M.; Davis, D. E. (28 July 2006). "Factors Affecting Persistence and Inactivation of Diquat and Paraquat".
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substantial stimulant of oxidative stress … and is associated with Parkinson's disease (PD)"; and stated that "From the studies we can consider that PQ and
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China also banned the domestic use of Paraquat in 2017; so followed Thailand in 2019 and Brazil, Chile, Malaysia, Peru and Taiwan between 2020 and 2022.
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Walsh, M. J.; Powles, S. B. (2007). "Management Strategies for Herbicide-resistant Weed Populations in Australian Dryland Crop Production Systems".
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A 17-year long, NIEHS-funded study of the links between Parkinson's disease, environment, and genes shows that some pesticides, including paraquat,
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manual states: "... toxic effects caused by this mechanism have been either very rare or nonexistent. Most paraquat that contaminates cannabis is
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Paraquat, the dication on the left, functions as an electron acceptor, disrupting respiration in plants by forming the monocation at the center.
880:. It is quick-acting and non-selective, killing green plant tissue on contact. It is also toxic (lethal) to human beings and animals due to its 5054: 4128: 3270: 2766:
Borger C.P.; Hashem A. (2007). "Evaluating the double knockdown technique: sequence, application interval, and annual ryegrass growth stage".
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Many studies identified genetic variations that provide insight into why certain people appear to be at higher risk of developing Parkinson's.
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Pratt, I. S.; Keeling, P. L.; Smith, L. L. (1980). "The Effect of High Concentrations of Oxygen on Paraquat and Diquat Toxicity in Rats".
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Vellingiri B, Chandrasekhar M, Sri Sabari S, Gopalakrishnan AV, Narayanasamy A, Venkatesan D, Iyer M, Kesari K, Dey A (September 2022).
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This article is about the herbicide. For the British military operation to recapture South Georgia Island during the Falklands War, see
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levels are below 92%, as high concentrations of oxygen intensify the toxic effects. Death may occur up to 30 days after ingestion.
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on the fields; marijuana contaminated with these substances began to show up in US markets, leading to debate about the program.
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in their respiratory tracts after a couple of weeks. This study was included in a report given to the State Department by the
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In addition, people exposed to pesticides in the home or garden may face a greater chance of developing Parkinson's disease.
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or other anions; quantities of the substance are sometimes expressed by cation mass alone (paraquat cation, paraquat ion).
1548: 5453: 4954: 2833: 1239:, which is presented with electrons from PS I) and transfers them to molecular oxygen. In this manner, destructive 332:
InChI=1/C12H14N2.2ClH/c1-13-7-3-11(4-8-13)12-5-9-14(2)10-6-12;;/h3-10H,1-2H3;2*1H/q+2;;/p-2/fC12H14N2.2Cl/h;2*1h/qm;2*-1
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were no indications of neurotoxicity associated with paraquat and that the studies about the link between paraquat and
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gene, which is important for the metabolism of organophosphate pesticides, showed faster progression of the disease.
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weeds may be addressed by applying herbicides with different modes of action, along with cultural methods such as
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Hu, Zhubing; Cools, Toon; De Veylder, Lieven (2016-04-29). "Mechanisms Used by Plants to Cope with DNA Damage".
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As an herbicide, paraquat acts by inhibiting photosynthesis. In light-exposed plants, it accepts electrons from
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In the United States, paraquat is available primarily as a solution in various strengths. It is classified as a
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Pezzoli, Gianni; Cereda, Emanuele (2013). "Exposure to pesticides or solvents and risk of Parkinson disease".
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Some people are more vulnerable to the harmful effects of pesticides because of their age or genetic makeup.
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The standard treatment for paraquat poisoning is first to remove as much as possible by pumping the stomach.
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Although first synthesized in 1882, paraquat's herbicidal properties were not recognized until 1955 in the
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stated that "this study should not be used to calculate the safe inhalation dose of paraquat in humans."
277: 159: 3325: 622: 552: 5382: 4626: 4400: 4232: 2590: 1495: 1291: 913: 908: 737: 724: 630: 4290: 3791:"Class-action lawsuit certified in B.C. against maker of herbicide that allegedly causes Parkinson's" 2342: 3766:"Judge Selects 10 Paraquat Lawsuits As Potential Bellwether Cases In Parkinson's Disease Litigation" 3159: 5308: 4970: 4883: 4227: 4023: 2165:). The synthesis is described on pages 863–864 and the molecule's structure is proposed on p. 867. 2046: 1827:(1875–1949) named paraquat "methyl viologen" and used it as an indicator in redox reactions. See: 1363: 1344: 1336: 1053: 294: 2994:"Inhibitory effect of pirfenidone on pulmonary fibrosis in patients with acute paraquat poisoning" 2175:
Calderbank, A.; et al. (1978). "Chapter 9: Bipyridylium herbicides". In Peacock, F.C. (ed.).
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During the late 1970s, a controversial program sponsored by the US government sprayed paraquat on
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Hood A. E. M. (1965). Ploughless farming using "Gramoxone". Outlook on Agriculture IV, 6, 286–294
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Li, Luying Ryan; Chaudhary, Bhuwan; You, Chao; Dennis, Jane A.; Wakeford, Helen (2021-06-30).
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should have been considered. Thus, paraquat has been banned in the European Union since 2007.
991:, Berkshire, England. Paraquat was first manufactured and sold by ICI in early 1962 under the 5508: 5372: 5288: 4805: 1609:, pesticide exposure has consistently been associated with the onset of Parkinson's disease. 1248: 1067:
In Australia, paraquat is used as a herbicide to control annual grasses, broadleaf weeds and
566: 540: 3965: 1117:, a process that is common to all life. Addition of one electron gives the radical cation: 596: 322:
InChI=1S/C12H14N2.2ClH/c1-13-7-3-11(4-8-13)12-5-9-14(2)10-6-12;;/h3-10H,1-2H3;2*1H/q+2;;/p-2
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Paraquat is often used in science to catalyze the formation of ROS, more specifically, the
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InChI=1/C12H14N2.2ClH/c1-13-7-3-11(4-8-13)12-5-9-14(2)10-6-12;;/h3-10H,1-2H3;2*1H/q+2;;/p-2
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with its combined effects has tremendous contribution towards neurodegeneration in PD."
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I (the highest of four levels) for acute inhalation effects. For agricultural uses, the
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killed two of his wives and his adoptive mother with paraquat between 1976 and 1984.
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studies on any possible association between Paraquat and Parkinson's". In the US, a
1251:. Target weeds die within 4 days; symptoms can show after as little as a few hours. 876:-active heterocycles of similar structure. This salt is one of the most widely used 3940: 3915: 3664: 3623: 3574: 3519: 3482: 3474: 3109: 3054: 3046: 3005: 2964: 2952: 2948: 2876: 2802: 2775: 2722: 2686: 2649: 2641: 2594: 2548: 2521: 2289: 2239: 2109: 1967: 1869: 1861: 1824: 1532: 1434: 1415: 1387: 896: 861: 857: 805: 474: 378: 2677:
Beckie, H. J. (2011). "Herbicide-resistant weed management: Focus on glyphosate".
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or paraquat, developed Parkinson's disease 2.5 times more often than non-users.
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Other NIEHS research found that people who occupationally used two pesticides,
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Similarly, other research has indicated that people with lower levels of the
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The radical cation is also susceptible to further reduction to the neutral :
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Other pesticides, like paraquat, have been found to increase production of
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Revkin, A. C. (1983). "Paraquat: A potent weed killer is killing people".
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Huggins D R & Reganold J. P. (2008). No-Till: the Quiet Revolution.
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A large majority (93 percent) of fatalities from paraquat poisoning are
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reproductive/fertility damage was not found by the EPA in their review.
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Use of other methylating agents gives the bispyridinium with alternate
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which may be responsible for the organ damage. It is known that the
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Except where otherwise noted, data are given for materials in their
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and broad-leaved weeds and the tips of established perennial weeds.
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and potentially leading to severe lung damage (e.g., irreversible
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These properties led to paraquat being used in the development of
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This article incorporates text from this source, which is in the
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Buzik, Shirley C.; Schiefer, H. Bruno; Irvine, Donald G. (1997).
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Jealott's Hill: Fifty years of Agricultural Research 1928-1978
1359:), and death. The mortality rate is estimated between 60–90%. 814: 592: 5322: 5205: 5114: 5104: 5089: 4643: 3445:"Parkinson disease A public health approach, Technical brief" 3363:
Dinham, B. (1996). "Active Ingredient fact sheet, Paraquat".
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Understanding Toxicology: Chemicals, Their Benefits and Risks
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Immediately Dangerous to Life or Health Concentrations (IDLH)
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Slade, P. (1966). "The Fate of Paraquat Applied to Plants".
3689: 2229: 1759:. International Programme on Chemical Safety. October 2001. 282: 5119: 4775: 4753: 4380: 4375: 3977: 3692:"UK farmers call for weedkiller ban over Parkinson's fears" 3604:"Neurotoxicity of pesticides - A link to neurodegeneration" 2749:"2024 HRAC Global Herbicide MOA Classification Master List" 1684: 1356: 817: 750: 584: 458:
175 to 180 °C (347 to 356 °F; 448 to 453 K)
433: 42: 3289:"Drug Survival News". Vol. 6, no. 5. March 1978. 2992:
Ren W, Chen Y, Wang Y, Wang C, Tian M, Gu X, Lv W (2021).
1637:, contribute to Parkinson's disease onset and progression. 826: 626: 3432:
Molecules of Murder: Criminal Molecules and Classic Cases
3108:. Archives of Toxicology. Vol. 4. pp. 415–418. 1558: 1317:
A computer simulation reported in the scientific journal
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Smith, S. N.; Lyon, A. J. E.; Sahid, Ismail BIN (1976).
3653:"Paraquat (herbicide) as a cause of Parkinson's Disease" 2711: 2538: 1298:. Paraquat is a Group L (Aus), D (global), 22 (numeric) 1266:, before being oxidized by an electron receptor such as 998:, and is today among the most commonly used herbicides. 576: 4634: 1200: 1143: 688:
3 mg/m (guinea pig, 30 min respirable dust)
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Paraquat Poisoning: Mechanisms, Prevention, Treatment
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Court of first instance of the European Communities,
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National Institute for Occupational Safety and Health
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National Institute for Occupational Safety and Health
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Paraquat dichloride; Methyl viologen dichloride; MVCl
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National Institute of Environmental Health Sciences
2276:Hood A. E. M.; Jameson H. R.; Cotterell R. (1963). 2206: 2204: 1565:include "banning of pesticides (e.g., paraquat and 1549:
Center for Public Integrity § Toxic Clout 2013
1486:, rats that inhaled paraquat showed development of 1022:
It is partially inactivated upon contact with soil.
808: 708:6400 mg/m (rat, nonrespirable dust, 4 h) 219: 3732: 3318:Recognition and Management of Pesticide Poisonings 3106:Further Studies in the Assessment of Toxic Actions 3035:"Cyclophosphamide treatment of paraquat poisoning" 2473: 2176: 1785:1,1′-Dimethyl-4,4′-bipyridinium dichloride hydrate 1658:on and off—in ways that persisted throughout life. 1362:Paraquat is also toxic when inhaled and is in the 1258:free radical. Paraquat will undergo redox cycling 1220: 1163: 949:to give the final product as the dichloride salt. 3103: 2578: 1207: 1206: 1150: 1149: 921: 888:anions. It has been linked to the development of 5470: 3741:"Syngenta paraquat secrets featured on ABC News" 2630:"Paraquat: model for oxidant-initiated toxicity" 2337: 2335: 2201: 1100: 686:3 mg/m (mouse, 30 min respirable dust) 572: 468:> 300 °C (572 °F; 573 K) 244: 3690:Claire Marshall; Malcolm Prior (1 April 2022). 3391:, Pestizid Aktions-Netzwerk e.V. (PAN Germany). 2991: 2392:"Estimated Agricultural Use for paraquat, 2018" 1048:USGS estimate of paraquat use in the US to 2018 94: 3595: 3461:Tanner, C. M.; Kamel, F.; et al. (2011). 588: 4969: 4955: 4024: 3988:. Centers for Disease Control and Prevention. 3885:Gillam, Carey; Uteuova, Aliya (20 Oct 2022). 3884: 3842: 3840: 3838: 3706: 3509: 3463:"Rotenone, Paraquat, and Parkinson's Disease" 3322:United States Environmental Protection Agency 2912:United States Environmental Protection Agency 2572: 2484:"4Farmers Australia Paraquat 250/300 Leaflet" 2332: 2256: 2183:. Imperial Chemical Industries Ltd. pp.  2088: 2086: 1844: 1469:United States Environmental Protection Agency 1368:United States Environmental Protection Agency 1277: 1262:, being reduced by an electron donor such as 4038: 3836: 3834: 3832: 3830: 3828: 3826: 3824: 3822: 3820: 3818: 3650: 2511: 1501: 1113:Paraquat is an oxidant that interferes with 706:1 mg/m (rat, respirable dust, 6 h) 4005:in the Pesticide Properties DataBase (PPDB) 3997:in the Pesticide Properties DataBase (PPDB) 3307:, pp. 37-51, New York: Marcel Dekker, 1995. 3032: 2941:The Cochrane Database of Systematic Reviews 2792: 2768:Australian Journal of Agricultural Research 2092: 1449: 4962: 4948: 4031: 4017: 3644: 3362: 2174: 2083: 1064:the purposes of the Rotterdam Convention. 297: 200: 178: 3944: 3897: 3815: 3627: 3578: 3486: 3058: 3009: 2968: 2653: 2627: 2293: 2141:and his student M. Russo synthesized the 1873: 1830: 264: 3986:"NIOSH Pocket Guide to Chemical Hazards" 3738: 3316:Reigart, J. Routt and Roberts, James R. 3195: 1939: 1734:NIOSH Pocket Guide to Chemical Hazards. 1561:(2022), some of the measures to prevent 1104: 1043: 3437: 3400: 1191: 1134: 846:′-dimethyl-4,4′-bipyridinium dichloride 293: 5471: 3788: 2676: 2034: 1948:"Paths from Pesticides to Parkinson's" 1911: 1909: 1845:Michaelis, L.; Hill, Edgar S. (1933). 1797: 1795: 1793: 1751: 1749: 1729: 1727: 1725: 1723: 1721: 1719: 1542: 191: 16:Chemical compound used as an herbicide 4943: 4012: 3225:. Boca Raton: CRC Press. p. 31. 2930: 2928: 2926: 2924: 2922: 2920: 2896: 2894: 2892: 2890: 2753:Herbicide Resistance Action Committee 2628:Bus; Gibson, JE; et al. (1984). 2599:10.1146/annurev-arplant-043015-111902 2461:from the original on 14 December 2018 2448: 2359: 2357: 1945: 1823:In 1932, the German-American chemist 1418:. The oxidative stress may result in 1221:{\displaystyle {\ce {<=>>}}} 1164:{\displaystyle {\ce {<=>>}}} 325:Key: FIKAKWIAUPDISJ-UHFFFAOYSA-L 158: 138: 3651:Sharma P, Mittal P (November 2023). 3552: 3303:, in: Bismuth C, and Hall AH (eds), 2363: 2168: 2145:salt of paraquat (which they called 1774: 1695:and Parkinson's disease, as well as 1691:Further research into links between 3553:Weed, Douglas L. (September 2021). 3087:Pre-Hospital Emergency Care Council 2834:Australian Broadcasting Corporation 2390:US Geological Survey (2021-10-12). 1927:from the original on April 26, 2019 1906: 1790: 1746: 1716: 1553:Rotenone § Parkinson's disease 1189: 1132: 342:Key: FIKAKWIAUPDISJ-NUQVWONBAF 235: 60:1,1′-Dimethyl-1,1′-diium dichloride 13: 3946:10.1111/j.1469-8137.1976.tb04668.x 3920:10.1111/j.1365-3180.1966.tb00876.x 3878: 3789:Ruttle, Joseph (August 14, 2024). 3301:Epidemiology of paraquat poisoning 3166: 2917: 2887: 2426:"Paraquat dichloride formulations" 2354: 2244:10.1111/j.1365-3180.1966.tb00867.x 14: 5530: 5479:Aldehyde dehydrogenase inhibitors 3978:"The Paraquat Information Center" 3954: 3739:Kelleher, Shannon (22 Nov 2023). 3467:Environmental Health Perspectives 2634:Environmental Health Perspectives 2449:Hakim, Danny (20 December 2016). 1854:The Journal of General Physiology 668:22 mg/kg (guinea pig, oral) 5504:Superoxide generating substances 3863: 3669:10.1016/j.parkreldis.2023.105932 2881:10.1046/j.0043-1737.2003.00356.x 2514:The Journal of Organic Chemistry 1302:herbicide, which it shares with 1005:It kills a wide range of annual 978: 952: 804: 556: 551: 546: 402: 396: 390: 41: 32: 5458:Monoamine metabolism modulators 3782: 3758: 3683: 3546: 3503: 3454: 3424: 3413:from the original on 2019-04-08 3394: 3375: 3356: 3337: 3320:, 5th edition. Washington, DC: 3310: 3293: 3282: 3264: 3253:from the original on 2018-03-22 3239: 3214: 3198:Nelson's Textbook of Pediatrics 3189: 3097: 3089:. February 2018. Archived from 3075: 3026: 2985: 2852: 2841:from the original on 2013-10-27 2821: 2786: 2759: 2741: 2705: 2670: 2621: 2569:. Academic Press, New York, NY. 2559: 2532: 2505: 2442: 2418: 2409: 2398:from the original on 2022-01-18 2383: 2319: 2310: 2269: 2250: 2223: 2128:from the original on 2021-07-04 2100:[Studies of pyridine]. 2072:from the original on 2018-10-06 2054: 1994:from the original on 2018-11-27 1893:from the original on 2019-08-16 1763:from the original on 2010-12-19 895:Paraquat may be in the form of 892:and is banned in 58 countries. 780:(at 25 °C , 100 kPa). 3980:. Syngenta Crop Protection AG. 3401:Premack, Rachel (2018-06-09). 2953:10.1002/14651858.CD008084.pub5 2582:Annual Review of Plant Biology 2364:Park, Cho (December 5, 2023). 2005: 1817: 1209: 1192: 1152: 1135: 1019:within minutes of application. 937:followed by oxidation to give 922:Production and redox reactions 510:Occupational safety and health 384: 1: 5450:Monoamine reuptake inhibitors 5430:Receptor/signaling modulators 1710: 1335:Paraquat is toxic to humans ( 1101:Reactivity and mode of action 929:is coupled by treatment with 906:The name is derived from the 718:(US health exposure limits): 3629:10.1016/j.ecoenv.2022.113972 3524:10.1212/wnl.0b013e318294b3c8 3114:10.1007/978-3-642-67729-8_95 2019:. 2023-12-20. Archived from 1484:Imperial Chemical Industries 985:Imperial Chemical Industries 664:120 mg/kg (mouse, oral) 523:Toxic, environmental hazard 7: 3580:10.1016/j.neuro.2021.08.006 3247:"每年5000绝望农民喝百草枯,自杀首选用药今起禁用" 3186:, accessed 13 October 2006. 3173:Centers for Disease Control 2567:The Bipyridinium Herbicides 1330: 967:'s original synthesis used 644:or concentration (LD, LC): 10: 5535: 5454:Monoamine releasing agents 3807:: CS1 maint: url-status ( 2914:, accessed 16 August 2007. 2098:"Studien über das Pyridin" 1787:. Retrieved on 2015-03-29. 1546: 1496:U.S. Public Health Service 1292:integrated weed management 1278:Weed resistance management 941:. This chemical is then di 744:TWA 0.1 mg/m (resp) 731:TWA 0.5 mg/m (resp) 18: 5499:Monoaminergic neurotoxins 5422: 5396: 5314:HHMA (α-methylepinine, α, 5229: 5166: 4977: 4971:Monoaminergic neurotoxins 4846: 4804: 4763:Photosystem II inhibitors 4761: 4752: 4677:Photosystem II inhibitors 4666: 4625: 4587: 4562: 4539: 4491: 4482: 4456: 4408: 4399: 4346: 4337: 4289: 4241: 4208: 4152: 4050: 3657:Parkinsonism Relat Disord 3200:(19 ed.). Elsevier. 1847:"The viologen indicators" 1502:Use in suicide and murder 884:activity, which produces 774: 712: 666:25 mg/kg (dog, oral) 662:57 mg/kg (rat, oral) 640: 527: 507: 502: 371: 351: 309: 78: 66: 54: 49: 40: 31: 4636:Photosystem I inhibitors 1833:Biochemische Zeitschrift 1510:, which occur mostly in 1414:species that results in 1054:restricted use pesticide 868:. It is classified as a 609:Precautionary statements 3299:Pronczuk de Garbino J, 2679:Pest Management Science 2343:Press Release No° 45/07 1972:10.1126/science.1243619 1569:) and chemicals (e.g., 1408:reactive oxygen species 1241:reactive oxygen species 1012:It is very fast-acting. 5309:HHA (α-methyldopamine) 3608:Ecotoxicol Environ Saf 2147:Dimethyldipyridyljodid 2102:Monatshefte für Chemie 1697:preventative therapies 1665:that can damage cells. 1629:pesticides, including 1424:induction of apoptosis 1420:mitochondrial toxicity 1404:oesophageal strictures 1343:and moderately toxic ( 1249:double-stranded breaks 1222: 1165: 1110: 1049: 987:(ICI) laboratories at 363:C1ccc(cc1)c2cc(cc2)C.. 5494:Avian embryotoxicants 5353:MDMA (midomafetamine) 3848:"Parkinson's Disease" 3326:Book available online 2329:, July 2008, pp 70–77 2137:The Austrian chemist 2062:"Paraquat and Diquat" 1757:"Paraquat dichloride" 1693:preventable exposures 1223: 1166: 1108: 1047: 5514:Pyridinium compounds 5216:Oxidopamine (6-OHDA) 5138:Oxidopamine (6-OHDA) 5128:-Methylnorsalsolinol 3382:Paraquat and Suicide 3177:Facts about Paraquat 3051:10.1136/thx.51.7.659 3033:Newstead CG (1996). 2565:Summers L.A. (1980) 2493:. 4Farmers Australia 2096:; Russo, M. (1882). 1866:10.1085/jgp.16.6.859 1512:developing countries 1182: 1125: 1061:Rotterdam Convention 680:median concentration 438:faint, ammonia-like 56:Preferred IUPAC name 5519:Parkinson's disease 5338:MDA (tenamfetamine) 5269:4-CAB (α-ethyl-PCA) 5211:MDA (tenamfetamine) 4864:aminocyclopyrachlor 4829:sulfometuron methyl 4002:Paraquat dichloride 3912:1966WeedR...6..158S 3854:. NIEHS. 2023-11-03 3620:2022EcoES.24313972V 3571:2021NeuTx..86..180W 3479:10.1289/ehp.1002839 3271:Panic over Paraquat 3004:(11): 13192–13199. 2901:Paraquat Dichloride 2873:2003WeedR..43..418N 2837:. 25 October 2013. 2807:10.1614/WT-06-086.1 2727:10.1614/WT-07-038.1 2553:10.1021/jo00300a033 2526:10.1021/jo00300a033 2491:www.4farmers.com.au 2327:Scientific American 1964:2013Sci...341..722K 1563:Parkinson's disease 1543:Parkinson's disease 1537:Steven David Catlin 1531:The indiscriminate 1514:. For instance, in 1488:squamous metaplasia 1284:herbicide resistant 1235:(more specifically 1195: 1138: 1036:Parkinson's disease 890:Parkinson's disease 475:Solubility in water 420: g·mol 28: 5318:-dimethyldopamine) 5001:-Cysteinyldopamine 4824:metsulfuron-methyl 4493:Nitrophenyl ethers 3966:Erklärung von Bern 3387:2008-07-25 at the 3331:2006-10-08 at the 3182:2005-12-23 at the 3093:on 15 August 2018. 2906:2008-02-27 at the 2646:10.1289/ehp.845537 2348:2011-09-29 at the 2114:10.1007/BF01516855 1946:Kamel, F. (2013). 1475:during smoking to 1428:lipid peroxidation 1379:activated charcoal 1353:pulmonary fibrosis 1218: 1213: 1197: 1161: 1156: 1140: 1111: 1050: 784:Infobox references 753:(Immediate danger) 26: 21:Operation Paraquet 5466: 5465: 5461: 4937: 4936: 4842: 4841: 4748: 4747: 4662: 4661: 4583: 4582: 4484:Protox inhibitors 4478: 4477: 4474: 4473: 4401:ACCase inhibitors 3518:(22): 2035–2041. 3232:978-0-8493-2686-8 3207:978-1-4377-0755-7 3196:Kliegman (2011). 3123:978-3-540-10191-8 2547:(13): 4127–4135. 2520:(13): 4127–4135. 2017:Los Angeles Times 1958:(6147): 722–723. 1781:Sigma-Aldrich Co. 1605:According to the 1571:trichloroethylene 1557:According to the 1492:Mitre Corporation 1364:Toxicity Category 1215: 1158: 1115:electron transfer 971:to produce the di 912:positions of the 852:), also known as 792:Chemical compound 790: 789: 763:Safety data sheet 567:Hazard statements 278:CompTox Dashboard 120:Interactive image 5526: 5424: 5075:Dopamine quinone 4964: 4957: 4950: 4941: 4940: 4759: 4758: 4673: 4672: 4632: 4631: 4541:Pyrimidinediones 4489: 4488: 4406: 4405: 4344: 4343: 4291:Organophosphorus 4033: 4026: 4019: 4010: 4009: 3989: 3981: 3973: 3968:. Archived from 3950: 3948: 3923: 3894: 3873: 3867: 3866: 3862: 3860: 3859: 3844: 3813: 3812: 3806: 3798: 3786: 3780: 3779: 3777: 3776: 3762: 3756: 3755: 3753: 3751: 3736: 3730: 3729: 3727: 3725: 3710: 3704: 3703: 3701: 3699: 3687: 3681: 3680: 3648: 3642: 3641: 3631: 3599: 3593: 3592: 3582: 3550: 3544: 3543: 3507: 3501: 3500: 3490: 3458: 3452: 3451: 3449: 3441: 3435: 3428: 3422: 3421: 3419: 3418: 3407:Business Insider 3398: 3392: 3379: 3373: 3372: 3360: 3354: 3353: 3341: 3335: 3314: 3308: 3297: 3291: 3290: 3286: 3280: 3268: 3262: 3261: 3259: 3258: 3243: 3237: 3236: 3218: 3212: 3211: 3193: 3187: 3170: 3164: 3163: 3157: 3153: 3151: 3143: 3101: 3095: 3094: 3079: 3073: 3072: 3062: 3030: 3024: 3023: 3013: 2989: 2983: 2982: 2972: 2932: 2915: 2898: 2885: 2884: 2856: 2850: 2849: 2847: 2846: 2825: 2819: 2818: 2790: 2784: 2783: 2763: 2757: 2756: 2745: 2739: 2738: 2709: 2703: 2702: 2674: 2668: 2667: 2657: 2625: 2619: 2618: 2576: 2570: 2563: 2557: 2556: 2536: 2530: 2529: 2509: 2503: 2502: 2500: 2498: 2488: 2480: 2471: 2470: 2468: 2466: 2446: 2440: 2439: 2437: 2436: 2422: 2416: 2413: 2407: 2406: 2404: 2403: 2387: 2381: 2380: 2378: 2376: 2361: 2352: 2339: 2330: 2323: 2317: 2314: 2308: 2307: 2297: 2295:10.1038/197748a0 2273: 2267: 2266: 2254: 2248: 2247: 2227: 2221: 2220: 2208: 2199: 2198: 2182: 2172: 2166: 2136: 2134: 2133: 2090: 2081: 2080: 2078: 2077: 2058: 2052: 2051: 2038: 2032: 2031: 2029: 2028: 2009: 2003: 2002: 2000: 1999: 1943: 1937: 1936: 1934: 1932: 1913: 1904: 1901: 1899: 1898: 1892: 1877: 1851: 1840: 1825:Leonor Michaelis 1821: 1815: 1814: 1799: 1788: 1778: 1772: 1771: 1769: 1768: 1753: 1744: 1743: 1731: 1590:lawsuit against 1533:paraquat murders 1435:epithelial cells 1416:oxidative stress 1388:cyclophosphamide 1300:resistance class 1227: 1225: 1224: 1219: 1217: 1216: 1214: 1212: 1205: 1198: 1196: 1187: 1170: 1168: 1167: 1162: 1160: 1159: 1157: 1155: 1148: 1141: 1139: 1130: 956: 862:chemical formula 858:organic compound 836: 835: 832: 831: 828: 825: 822: 819: 816: 813: 810: 700:lowest published 636: 632: 628: 624: 620: 616: 602: 598: 594: 590: 586: 582: 578: 574: 560: 555: 550: 497: 495: 419: 404: 398: 392: 386: 379:Chemical formula 302: 301: 286: 284: 268: 248: 237: 223: 204: 193: 182: 162: 142: 122: 98: 45: 36: 29: 25: 5534: 5533: 5529: 5528: 5527: 5525: 5524: 5523: 5469: 5468: 5467: 5462: 5418: 5392: 5368:Norfenfluramine 5358:Methamphetamine 5225: 5162: 5115:MPP (cyperquat) 5110:Methamphetamine 5021:ALDH inhibitors 4973: 4968: 4938: 4933: 4838: 4800: 4744: 4658: 4621: 4579: 4558: 4535: 4470: 4452: 4395: 4333: 4285: 4251:flurochloridone 4237: 4223:copper arsenate 4204: 4148: 4046: 4037: 3984: 3976: 3962:"Stop Paraquat" 3960: 3957: 3933:New Phytologist 3881: 3879:Further reading 3876: 3864: 3857: 3855: 3846: 3845: 3816: 3800: 3799: 3787: 3783: 3774: 3772: 3764: 3763: 3759: 3749: 3747: 3737: 3733: 3723: 3721: 3712: 3711: 3707: 3697: 3695: 3688: 3684: 3649: 3645: 3600: 3596: 3559:NeuroToxicology 3551: 3547: 3508: 3504: 3459: 3455: 3447: 3443: 3442: 3438: 3429: 3425: 3416: 3414: 3399: 3395: 3389:Wayback Machine 3380: 3376: 3361: 3357: 3343: 3342: 3338: 3333:Wayback Machine 3315: 3311: 3298: 3294: 3288: 3287: 3283: 3269: 3265: 3256: 3254: 3245: 3244: 3240: 3233: 3219: 3215: 3208: 3194: 3190: 3184:Wayback Machine 3171: 3167: 3155: 3154: 3145: 3144: 3124: 3102: 3098: 3081: 3080: 3076: 3031: 3027: 2998:Am J Transl Res 2990: 2986: 2947:(6): CD008084. 2933: 2918: 2908:Wayback Machine 2899: 2888: 2857: 2853: 2844: 2842: 2827: 2826: 2822: 2795:Weed Technology 2791: 2787: 2780:10.1071/ar05373 2764: 2760: 2747: 2746: 2742: 2715:Weed Technology 2710: 2706: 2691:10.1002/ps.2195 2675: 2671: 2626: 2622: 2577: 2573: 2564: 2560: 2537: 2533: 2510: 2506: 2496: 2494: 2486: 2482: 2481: 2474: 2464: 2462: 2447: 2443: 2434: 2432: 2424: 2423: 2419: 2414: 2410: 2401: 2399: 2388: 2384: 2374: 2372: 2362: 2355: 2350:Wayback Machine 2340: 2333: 2324: 2320: 2315: 2311: 2274: 2270: 2255: 2251: 2228: 2224: 2213:Pesticides News 2210: 2209: 2202: 2195: 2173: 2169: 2151:4,4'-bipyridine 2131: 2129: 2091: 2084: 2075: 2073: 2060: 2059: 2055: 2040: 2039: 2035: 2026: 2024: 2011: 2010: 2006: 1997: 1995: 1944: 1940: 1930: 1928: 1915: 1914: 1907: 1896: 1894: 1890: 1849: 1822: 1818: 1801: 1800: 1791: 1779: 1775: 1766: 1764: 1755: 1754: 1747: 1732: 1717: 1713: 1627:organophosphate 1555: 1545: 1504: 1452: 1396: 1384:glucocorticoids 1333: 1280: 1274:, a major ROS. 1208: 1201: 1199: 1190: 1188: 1186: 1185: 1183: 1180: 1179: 1151: 1144: 1142: 1133: 1131: 1129: 1128: 1126: 1123: 1122: 1103: 1028:no-till farming 981: 963:. For example, 939:4,4′-bipyridine 924: 867: 854:methyl viologen 850:systematic name 807: 803: 793: 786: 781: 754: 741: 728: 707: 703: 697: 687: 683: 677: 667: 665: 663: 659: 653: 611: 569: 543: 520: 493: 491: 477: 417: 407: 401: 395: 389: 381: 367: 364: 359: 358: 347: 344: 343: 340: 334: 333: 327: 326: 323: 317: 316: 305: 287: 280: 271: 251: 238: 226: 213: 185: 165: 145: 125: 112: 101: 88: 74: 72: 62: 61: 24: 17: 12: 11: 5: 5532: 5522: 5521: 5516: 5511: 5506: 5501: 5496: 5491: 5486: 5481: 5464: 5463: 5423: 5420: 5419: 5417: 5416: 5411: 5406: 5400: 5398: 5394: 5393: 5391: 5390: 5385: 5380: 5375: 5370: 5365: 5360: 5355: 5350: 5345: 5340: 5335: 5330: 5325: 5320: 5311: 5306: 5301: 5296: 5291: 5286: 5281: 5276: 5271: 5266: 5261: 5256: 5251: 5246: 5241: 5235: 5233: 5227: 5226: 5224: 5223: 5218: 5213: 5208: 5203: 5198: 5193: 5188: 5183: 5178: 5172: 5170: 5164: 5163: 5161: 5160: 5155: 5150: 5145: 5140: 5135: 5130: 5122: 5117: 5112: 5107: 5102: 5097: 5092: 5087: 5082: 5077: 5072: 5067: 5062: 5057: 5052: 5047: 5042: 5037: 5032: 5018: 5016:6-OHDA quinone 5013: 5008: 5003: 4994: 4989: 4983: 4981: 4975: 4974: 4967: 4966: 4959: 4952: 4944: 4935: 4934: 4932: 4931: 4926: 4921: 4916: 4911: 4906: 4901: 4896: 4891: 4886: 4881: 4876: 4871: 4866: 4861: 4856: 4850: 4848: 4844: 4843: 4840: 4839: 4837: 4836: 4831: 4826: 4821: 4816: 4810: 4808: 4806:ALS inhibitors 4802: 4801: 4799: 4798: 4793: 4788: 4783: 4778: 4773: 4767: 4765: 4756: 4750: 4749: 4746: 4745: 4743: 4742: 4737: 4732: 4730:terbuthylazine 4727: 4722: 4717: 4712: 4707: 4702: 4697: 4692: 4687: 4681: 4679: 4670: 4664: 4663: 4660: 4659: 4657: 4656: 4651: 4646: 4640: 4638: 4629: 4623: 4622: 4620: 4619: 4614: 4609: 4604: 4599: 4593: 4591: 4585: 4584: 4581: 4580: 4578: 4577: 4572: 4566: 4564: 4560: 4559: 4557: 4556: 4551: 4545: 4543: 4537: 4536: 4534: 4533: 4528: 4523: 4518: 4513: 4508: 4503: 4497: 4495: 4486: 4480: 4479: 4476: 4475: 4472: 4471: 4469: 4468: 4462: 4460: 4458:DIM herbicides 4454: 4453: 4451: 4450: 4445: 4440: 4435: 4430: 4425: 4420: 4414: 4412: 4410:FOP herbicides 4403: 4397: 4396: 4394: 4393: 4388: 4383: 4378: 4373: 4368: 4363: 4358: 4352: 4350: 4341: 4335: 4334: 4332: 4331: 4326: 4321: 4316: 4311: 4306: 4301: 4295: 4293: 4287: 4286: 4284: 4283: 4278: 4273: 4268: 4263: 4258: 4253: 4247: 4245: 4243:HPPD inhbitors 4239: 4238: 4236: 4235: 4230: 4225: 4220: 4218:cacodylic acid 4214: 4212: 4206: 4205: 4203: 4202: 4197: 4192: 4187: 4182: 4177: 4172: 4167: 4161: 4159: 4150: 4149: 4147: 4146: 4141: 4136: 4131: 4126: 4121: 4116: 4111: 4106: 4101: 4096: 4091: 4086: 4081: 4076: 4071: 4066: 4060: 4058: 4048: 4047: 4036: 4035: 4028: 4021: 4013: 4007: 4006: 3998: 3990: 3982: 3974: 3972:on 2007-06-08. 3956: 3955:External links 3953: 3952: 3951: 3939:(3): 735–740. 3924: 3906:(2): 158–167. 3895: 3880: 3877: 3875: 3874: 3814: 3781: 3757: 3731: 3705: 3682: 3643: 3594: 3545: 3502: 3473:(6): 866–872. 3453: 3436: 3430:Emsley, John. 3423: 3393: 3374: 3365:Pesticide News 3355: 3336: 3309: 3292: 3281: 3263: 3238: 3231: 3213: 3206: 3188: 3165: 3156:|journal= 3122: 3096: 3074: 3025: 2984: 2916: 2886: 2867:(6): 418–427. 2851: 2820: 2801:(2): 332–338. 2785: 2774:(3): 265–271. 2758: 2740: 2704: 2685:(9): 1037–48. 2669: 2620: 2591:Annual Reviews 2571: 2558: 2531: 2504: 2472: 2455:New York Times 2441: 2417: 2408: 2382: 2353: 2331: 2318: 2309: 2268: 2259:Science Digest 2249: 2222: 2219:: 20–21. 1996. 2200: 2193: 2167: 2149:) by reacting 2082: 2053: 2033: 2004: 1938: 1905: 1903: 1902: 1860:(6): 859–873. 1841: 1816: 1789: 1773: 1745: 1714: 1712: 1709: 1689: 1688: 1681: 1674: 1667: 1666: 1659: 1655: 1652: 1649: 1642: 1638: 1625:, and several 1544: 1541: 1503: 1500: 1482:In a study by 1451: 1450:"Paraquat pot" 1448: 1394: 1375:Fuller's earth 1332: 1329: 1324:Lolium rigidum 1282:Problems with 1279: 1276: 1229: 1228: 1211: 1204: 1194: 1172: 1171: 1154: 1147: 1137: 1102: 1099: 1024: 1023: 1020: 1013: 1010: 989:Jealott's Hill 980: 977: 923: 920: 872:, a family of 865: 791: 788: 787: 782: 778:standard state 775: 772: 771: 766: 759: 758: 755: 749: 746: 745: 742: 736: 733: 732: 729: 723: 720: 719: 710: 709: 704: 695: 693: 690: 689: 684: 675: 673: 670: 669: 660: 651: 649: 646: 645: 638: 637: 635:P305+P351+P338 612: 607: 604: 603: 570: 565: 562: 561: 544: 539: 536: 535: 525: 524: 521: 518: 515: 514: 505: 504: 500: 499: 488: 486:Vapor pressure 482: 481: 478: 473: 470: 469: 466: 460: 459: 456: 450: 449: 446: 440: 439: 436: 430: 429: 426: 422: 421: 415: 409: 408: 405: 399: 393: 387: 382: 377: 374: 373: 369: 368: 366: 365: 362: 354: 353: 352: 349: 348: 346: 345: 341: 338: 337: 335: 331: 330: 328: 324: 321: 320: 312: 311: 310: 307: 306: 304: 303: 290: 288: 276: 273: 272: 270: 269: 261: 259: 253: 252: 250: 249: 241: 239: 231: 228: 227: 225: 224: 216: 214: 209: 206: 205: 195: 187: 186: 184: 183: 175: 173: 167: 166: 164: 163: 155: 153: 147: 146: 144: 143: 135: 133: 127: 126: 124: 123: 115: 113: 106: 103: 102: 100: 99: 91: 89: 84: 81: 80: 76: 75: 70: 68: 64: 63: 59: 58: 52: 51: 47: 46: 38: 37: 15: 9: 6: 4: 3: 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5131: 5129: 5127: 5123: 5121: 5118: 5116: 5113: 5111: 5108: 5106: 5103: 5101: 5098: 5096: 5093: 5091: 5088: 5086: 5083: 5081: 5080:Fenpropathrin 5078: 5076: 5073: 5071: 5068: 5066: 5065:DOPAL quinone 5063: 5061: 5058: 5056: 5053: 5051: 5048: 5046: 5043: 5041: 5038: 5036: 5033: 5030: 5029:methylmercury 5026: 5022: 5019: 5017: 5014: 5012: 5011:6-Hydroxydopa 5009: 5007: 5004: 5002: 5000: 4995: 4993: 4990: 4988: 4985: 4984: 4982: 4980: 4976: 4972: 4965: 4960: 4958: 4953: 4951: 4946: 4945: 4942: 4930: 4927: 4925: 4922: 4920: 4917: 4915: 4912: 4910: 4907: 4905: 4902: 4900: 4897: 4895: 4892: 4890: 4887: 4885: 4882: 4880: 4877: 4875: 4872: 4870: 4867: 4865: 4862: 4860: 4857: 4855: 4852: 4851: 4849: 4845: 4835: 4832: 4830: 4827: 4825: 4822: 4820: 4819:flazasulfuron 4817: 4815: 4814:chlorsulfuron 4812: 4811: 4809: 4807: 4803: 4797: 4794: 4792: 4789: 4787: 4784: 4782: 4779: 4777: 4774: 4772: 4769: 4768: 4766: 4764: 4760: 4757: 4755: 4751: 4741: 4738: 4736: 4733: 4731: 4728: 4726: 4723: 4721: 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4272: 4269: 4267: 4264: 4262: 4261:leptospermone 4259: 4257: 4254: 4252: 4249: 4248: 4246: 4244: 4240: 4234: 4231: 4229: 4226: 4224: 4221: 4219: 4216: 4215: 4213: 4211: 4207: 4201: 4198: 4196: 4193: 4191: 4188: 4186: 4183: 4181: 4178: 4176: 4173: 4171: 4168: 4166: 4163: 4162: 4160: 4158: 4155: 4151: 4145: 4142: 4140: 4137: 4135: 4132: 4130: 4127: 4125: 4124:pendimethalin 4122: 4120: 4117: 4115: 4112: 4110: 4107: 4105: 4102: 4100: 4097: 4095: 4092: 4090: 4087: 4085: 4082: 4080: 4077: 4075: 4072: 4070: 4067: 4065: 4062: 4061: 4059: 4057: 4053: 4049: 4045: 4041: 4034: 4029: 4027: 4022: 4020: 4015: 4014: 4011: 4004: 4003: 3999: 3996: 3995: 3991: 3987: 3983: 3979: 3975: 3971: 3967: 3963: 3959: 3958: 3947: 3942: 3938: 3934: 3930: 3925: 3921: 3917: 3913: 3909: 3905: 3901: 3900:Weed Research 3896: 3892: 3888: 3883: 3882: 3871: 3870:public domain 3853: 3849: 3843: 3841: 3839: 3837: 3835: 3833: 3831: 3829: 3827: 3825: 3823: 3821: 3819: 3810: 3804: 3796: 3795:Vancouver Sun 3792: 3785: 3771: 3770:Drugwatch.com 3767: 3761: 3746: 3742: 3735: 3720:. 28 Nov 2023 3719: 3715: 3709: 3693: 3686: 3678: 3674: 3670: 3666: 3662: 3658: 3654: 3647: 3639: 3635: 3630: 3625: 3621: 3617: 3613: 3609: 3605: 3598: 3590: 3586: 3581: 3576: 3572: 3568: 3564: 3560: 3556: 3549: 3541: 3537: 3533: 3529: 3525: 3521: 3517: 3513: 3506: 3498: 3494: 3489: 3484: 3480: 3476: 3472: 3468: 3464: 3457: 3446: 3440: 3433: 3427: 3412: 3408: 3404: 3397: 3390: 3386: 3383: 3378: 3370: 3366: 3359: 3351: 3347: 3340: 3334: 3330: 3327: 3323: 3319: 3313: 3306: 3302: 3296: 3285: 3279:, May 1, 1978 3278: 3277: 3276:Time Magazine 3272: 3267: 3252: 3248: 3242: 3234: 3228: 3224: 3217: 3209: 3203: 3199: 3192: 3185: 3181: 3178: 3174: 3169: 3161: 3149: 3141: 3137: 3133: 3129: 3125: 3119: 3115: 3111: 3107: 3100: 3092: 3088: 3084: 3078: 3070: 3066: 3061: 3056: 3052: 3048: 3045:(7): 659–60. 3044: 3040: 3036: 3029: 3021: 3017: 3012: 3007: 3003: 2999: 2995: 2988: 2980: 2976: 2971: 2966: 2962: 2958: 2954: 2950: 2946: 2942: 2938: 2931: 2929: 2927: 2925: 2923: 2921: 2913: 2909: 2905: 2902: 2897: 2895: 2893: 2891: 2882: 2878: 2874: 2870: 2866: 2862: 2861:Weed Research 2855: 2840: 2836: 2835: 2830: 2829:"in ryegrass" 2824: 2816: 2812: 2808: 2804: 2800: 2796: 2789: 2781: 2777: 2773: 2769: 2762: 2754: 2750: 2744: 2736: 2732: 2728: 2724: 2720: 2716: 2708: 2700: 2696: 2692: 2688: 2684: 2680: 2673: 2665: 2661: 2656: 2651: 2647: 2643: 2639: 2635: 2631: 2624: 2616: 2612: 2608: 2604: 2600: 2596: 2592: 2588: 2584: 2583: 2575: 2568: 2562: 2554: 2550: 2546: 2542: 2535: 2527: 2523: 2519: 2515: 2508: 2492: 2485: 2479: 2477: 2460: 2456: 2452: 2445: 2431: 2427: 2421: 2412: 2397: 2393: 2386: 2371: 2367: 2360: 2358: 2351: 2347: 2344: 2338: 2336: 2328: 2322: 2313: 2305: 2301: 2296: 2291: 2288:(4869): 381. 2287: 2283: 2279: 2272: 2264: 2260: 2253: 2245: 2241: 2237: 2233: 2232:Weed Research 2226: 2218: 2214: 2207: 2205: 2196: 2190: 2186: 2181: 2180: 2171: 2164: 2160: 2159:methyl iodide 2156: 2152: 2148: 2144: 2140: 2127: 2123: 2119: 2115: 2111: 2107: 2104:(in German). 2103: 2099: 2095: 2089: 2087: 2071: 2067: 2063: 2057: 2050:. 2023-11-28. 2049: 2048: 2043: 2037: 2023:on 2023-12-20 2022: 2018: 2014: 2008: 1993: 1989: 1985: 1981: 1977: 1973: 1969: 1965: 1961: 1957: 1953: 1949: 1942: 1926: 1922: 1921:Science Daily 1918: 1912: 1910: 1889: 1885: 1881: 1876: 1871: 1867: 1863: 1859: 1855: 1848: 1842: 1838: 1835:(in German). 1834: 1829: 1828: 1826: 1820: 1812: 1808: 1804: 1798: 1796: 1794: 1786: 1782: 1777: 1762: 1758: 1752: 1750: 1741: 1737: 1730: 1728: 1726: 1724: 1722: 1720: 1715: 1708: 1706: 1702: 1698: 1694: 1686: 1682: 1679: 1675: 1672: 1671: 1670: 1664: 1663:free radicals 1660: 1656: 1653: 1650: 1647: 1643: 1639: 1636: 1632: 1628: 1624: 1620: 1616: 1612: 1611: 1610: 1608: 1603: 1599: 1597: 1593: 1589: 1583: 1581: 1576: 1572: 1568: 1564: 1560: 1554: 1550: 1540: 1538: 1534: 1529: 1526: 1525:Isabella Blow 1522: 1517: 1513: 1509: 1499: 1497: 1493: 1489: 1485: 1480: 1478: 1474: 1470: 1464: 1462: 1457: 1447: 1443: 1441: 1436: 1433: 1429: 1425: 1421: 1417: 1413: 1409: 1405: 1402:failure, and 1399: 1397: 1389: 1385: 1380: 1376: 1371: 1369: 1365: 1360: 1358: 1354: 1350: 1346: 1342: 1338: 1328: 1326: 1325: 1320: 1319:Weed Research 1315: 1311: 1309: 1305: 1301: 1297: 1293: 1289: 1288:crop rotation 1285: 1275: 1273: 1269: 1265: 1261: 1257: 1252: 1250: 1246: 1242: 1238: 1234: 1233:photosystem I 1202: 1177: 1176: 1175: 1145: 1120: 1119: 1118: 1116: 1107: 1098: 1096: 1094: 1090: 1086: 1082: 1078: 1074: 1070: 1065: 1062: 1057: 1055: 1046: 1042: 1039: 1037: 1031: 1029: 1021: 1018: 1014: 1011: 1008: 1004: 1003: 1002: 999: 997: 994: 990: 986: 979:Herbicide use 976: 974: 970: 969:methyl iodide 966: 962: 957: 955: 950: 948: 947:chloromethane 944: 940: 936: 932: 928: 919: 917: 916: 911: 910: 904: 902: 898: 893: 891: 887: 883: 879: 875: 871: 863: 859: 855: 851: 847: 845: 841: 834: 801: 797: 785: 779: 773: 770: 767: 764: 761: 760: 756: 752: 748: 747: 743: 740:(Recommended) 739: 735: 734: 730: 727:(Permissible) 726: 722: 721: 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5142: 5125: 5055:DOPA quinone 4998: 4979:Dopaminergic 4924:pyribenzoxim 4919:prosulfocarb 4909:metam sodium 4771:chlortoluron 4653: 4554:saflufenacil 4256:isoxaflutole 4165:aminopyralid 4129:pretilachlor 4099:dimethenamid 4094:diflufenican 4040:Pest control 4000: 3992: 3970:the original 3936: 3932: 3903: 3899: 3891:The Guardian 3890: 3856:. Retrieved 3851: 3794: 3784: 3773:. Retrieved 3769: 3760: 3748:. Retrieved 3745:The New Lede 3744: 3734: 3722:. Retrieved 3717: 3708: 3696:. Retrieved 3685: 3660: 3656: 3646: 3611: 3607: 3597: 3562: 3558: 3548: 3515: 3511: 3505: 3470: 3466: 3456: 3439: 3431: 3426: 3415:. Retrieved 3406: 3396: 3377: 3368: 3364: 3358: 3349: 3345: 3344:"Paraquat". 3339: 3317: 3312: 3304: 3300: 3295: 3284: 3274: 3266: 3255:. Retrieved 3241: 3222: 3216: 3197: 3191: 3168: 3105: 3099: 3091:the original 3086: 3077: 3042: 3038: 3028: 3001: 2997: 2987: 2944: 2940: 2864: 2860: 2854: 2843:. Retrieved 2832: 2823: 2798: 2794: 2788: 2771: 2767: 2761: 2752: 2743: 2718: 2714: 2707: 2682: 2678: 2672: 2637: 2633: 2623: 2586: 2580: 2574: 2566: 2561: 2544: 2541:J. Org. Chem 2540: 2534: 2517: 2513: 2507: 2497:13 September 2495:. Retrieved 2490: 2463:. Retrieved 2454: 2444: 2433:. Retrieved 2429: 2420: 2411: 2400:. Retrieved 2385: 2373:. Retrieved 2369: 2326: 2321: 2312: 2285: 2281: 2271: 2262: 2258: 2252: 2238:(1): 58–66. 2235: 2231: 2225: 2216: 2212: 2211:"Paraquat". 2178: 2170: 2162: 2154: 2146: 2130:. Retrieved 2105: 2101: 2074:. Retrieved 2056: 2045: 2036: 2025:. Retrieved 2021:the original 2016: 2007: 1996:. Retrieved 1955: 1951: 1941: 1929:. Retrieved 1920: 1895:. Retrieved 1857: 1853: 1836: 1832: 1819: 1806: 1776: 1765:. Retrieved 1690: 1668: 1635:chlorpyrifos 1604: 1600: 1588:class action 1584: 1574: 1567:chlorpyrifos 1556: 1530: 1505: 1481: 1465: 1453: 1444: 1440:asphyxiation 1400: 1372: 1361: 1349:inflammation 1345:Category III 1334: 1322: 1318: 1316: 1312: 1281: 1259: 1253: 1230: 1173: 1112: 1097: 1071:in crops of 1066: 1058: 1051: 1040: 1032: 1025: 1000: 995: 982: 958: 951: 925: 914: 907: 905: 894: 853: 843: 839: 838: 800:trivial name 795: 794: 769:Aldrich MSDS 757:1 mg/m 714: 641: 529: 519:Main hazards 508: 160:ChEMBL458019 79:Identifiers 67:Other names 5489:Bipyridines 5434:Adrenergics 5304:Haloperidol 5085:Haloperidol 5035:Amphetamine 4796:tebuthiuron 4791:monolinuron 4549:butafenacil 4531:oxyfluorfen 4511:fluorodifen 4501:acifluorfen 4418:chlorazifop 4366:dichlorprop 4319:glufosinate 4281:sulcotrione 4190:pyrithiobac 4144:trifluralin 4114:metolachlor 4109:metazachlor 4079:benfluralin 3565:: 180–184. 3352:(91). 1983. 2593:: 439–462. 2465:21 December 2430:www.pic.int 2265:(6): 36–38. 2155:γ-Dipyridyl 2139:Hugo Weidel 2108:: 850–885. 2066:IPCS INCHEM 1931:October 25, 1705:trifluralin 1337:Category II 1270:to produce 965:Hugo Weidel 961:counterions 918:nitrogens. 656:median dose 642:Lethal dose 513:(OHS/OSH): 425:Appearance 372:Properties 198:100.016.015 140:CHEBI:28786 5484:Herbicides 5473:Categories 5254:2,4,5-THMA 5153:Salsolinol 5025:disulfiram 4992:2,4,5-THMA 4914:metribuzin 4894:indaziflam 4874:bromoxynil 4834:tribenuron 4740:metamitron 4700:hexazinone 4627:Quaternary 4602:fluroxypyr 4466:sethoxydim 4448:quizalofop 4433:fenoxaprop 4329:piperophos 4324:glyphosate 4276:sethoxydim 4271:nitisinone 4266:mesotrione 4210:Arsenicals 4195:quinclorac 4175:clopyralid 4170:chloramben 4134:propachlor 4064:acetochlor 4044:herbicides 3858:2023-12-04 3775:2024-08-19 3694:. BBC News 3663:: 105932. 3614:: 113972. 3417:2019-04-08 3346:High Times 3257:2018-03-21 2845:2013-10-27 2435:2023-10-19 2402:2022-01-17 2194:0901747017 2132:2019-08-13 2094:Weidel, H. 2076:2009-02-03 2027:2023-12-21 1998:2018-09-13 1897:2019-08-16 1843:See also: 1839:: 564–567. 1803:"Paraquat" 1767:2007-09-06 1711:References 1701:permethrin 1547:See also: 1341:oral route 1296:glyphosate 1272:superoxide 1256:superoxide 1237:ferredoxin 1081:field peas 1077:Faba beans 993:trade name 943:methylated 915:quaternary 886:superoxide 878:herbicides 541:Pictograms 496: mmHg 448:1.25 g/cm 413:Molar mass 266:2KZ83GSS73 211:IUPHAR/BPS 171:ChemSpider 107:3D model ( 86:CAS Number 5427:See also: 5249:2,4,5-THA 5181:2,4,5-THA 4987:2,4,5-THA 4904:methazole 4879:clomazone 4859:aclonifen 4735:terbutryn 4715:propazine 4710:prometryn 4695:cyanazine 4668:Triazines 4644:cyperquat 4617:triclopyr 4612:thiazopyr 4597:dithiopyr 4589:Pyridines 4516:fomesafen 4443:haloxyfop 4438:fluazifop 4423:cyhalofop 4304:bialaphos 4299:bensulide 4200:quinmerac 4089:diethatyl 4084:butachlor 3803:cite news 3512:Neurology 3158:ignored ( 3148:cite book 3132:0171-9750 2961:1469-493X 2721:: 16–21. 2640:: 37–46. 2607:1543-5008 2163:Jodmethyl 1575:Neurology 1477:dipyridyl 1473:pyrolyzed 1339:) by the 1308:cyperquat 1210:⇀ 1203:− 1193:↽ 1153:⇀ 1146:− 1136:↽ 1073:Chickpeas 1017:rain-fast 996:Gramoxone 860:with the 631:P301+P310 532:labelling 96:1910-42-5 27:Paraquat 5397:Unsorted 5221:Xylamine 5148:Rotenone 5143:Paraquat 5100:Mancozeb 5070:Dopamine 5050:Dieldrin 4869:Bentazon 4725:simetryn 4720:simazine 4705:prometon 4690:atrazine 4654:paraquat 4607:imazapyr 4526:nitrofen 4521:lactofen 4428:diclofop 4386:mecoprop 4371:fenoprop 4314:fosamine 4309:ethephon 4185:picloram 4154:Aromatic 4139:propanil 4119:oryzalin 4104:flamprop 4069:alachlor 4056:anilines 4052:Anilides 3994:Paraquat 3718:ABC News 3677:38008593 3638:36029574 3589:34400206 3540:13628268 3532:23713084 3497:21269927 3411:Archived 3385:Archived 3371:: 20–21. 3329:Archived 3324:, 1999. 3251:Archived 3180:Archived 3020:34956540 2979:34190331 2904:Archived 2839:Archived 2815:86844036 2735:86158165 2699:21548004 2615:26653616 2459:Archived 2396:Archived 2370:ABC News 2346:Archived 2304:31392210 2126:Archived 2122:97065714 2070:Archived 2047:ABC News 1992:Archived 1988:11119082 1980:23950519 1925:Archived 1923:. 2011. 1888:Archived 1884:19872744 1813:(NIOSH). 1761:Archived 1742:(NIOSH). 1646:rotenone 1631:diazinon 1592:Syngenta 1521:Trinidad 1508:suicides 1456:cannabis 1432:alveolar 1422:and the 1331:Toxicity 1268:dioxygen 1245:necrosis 1069:ryegrass 927:Pyridine 901:chloride 870:viologen 856:, is an 796:Paraquat 503:Hazards 5284:5,7-DHT 5279:5,6-DHT 5264:3,4-DCA 5244:2,4-DCA 5201:DOPEGAL 5191:5,7-DHT 5186:5,6-DHT 5045:Daidzin 5040:Benomyl 5023:(e.g., 5006:5,6-DHT 4899:juglone 4889:dinoseb 4786:monuron 4781:linuron 4685:ametryn 4506:bifenox 4391:2,4,5-T 4339:Phenoxy 4180:dicamba 3908:Bibcode 3698:1 April 3616:Bibcode 3567:Bibcode 3488:3114824 3450:. 2022. 3140:6933951 3069:8882068 3011:8661212 2970:8243635 2869:Bibcode 2664:6329674 2655:1568364 2375:July 7, 2157:) with 1960:Bibcode 1952:Science 1875:2141252 1736:"#0478" 1623:benomyl 1596:Chevron 1412:nitrite 1260:in vivo 1178:+ e 1121:+ e 1089:lentils 1007:grasses 935:ammonia 444:Density 233:PubChem 5404:5-HIAL 4847:Others 4649:diquat 4361:2,4-DB 4348:Auxins 4074:asulam 3750:29 Nov 3724:29 Nov 3675:  3636:  3587:  3538:  3530:  3495:  3485:  3229:  3204:  3138:  3130:  3120:  3067:  3060:472483 3057:  3039:Thorax 3018:  3008:  2977:  2967:  2959:  2813:  2733:  2697:  2662:  2652:  2613:  2605:  2302:  2282:Nature 2191:  2143:iodide 2120:  1986:  1978:  1882:  1872:  1703:, and 1641:found. 1551:, and 1494:. 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Index

Operation Paraquet


Preferred IUPAC name
CAS Number
1910-42-5
JSmol
Interactive image
ChEBI
CHEBI:28786
ChEMBL
ChEMBL458019
ChemSpider
15146
ECHA InfoCard
100.016.015
Edit this at Wikidata
IUPHAR/BPS
4552
PubChem
15938
UNII
2KZ83GSS73
CompTox Dashboard
DTXSID7024243
Edit this at Wikidata
InChI
SMILES
Chemical formula
Molar mass

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