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In 1885, he married
Margarethe Ebart, the widow of one of his patients. They travelled to Berlin for the wedding, and he met his father, sisters and two brothers for the last time. The newly-weds rented Quinta Lambert, known as the most beautiful villa in Funchal and now the Official Residence of the
384:
He practiced as a physician in
Funchal, treating mostly fellow tuberculosis sufferers, and published scientific papers about the condition in Virchow's archive. Not content with this, he also wrote a handbook for travellers to the island, and pursued studies in
377:, where he made a partial recovery and launched himself into a new career with undiminished energy. He began studying marine worms, making regular trips down to the harbour to pick over the fishermens’ nets. His publications describing and classifying marine
206:– In the same paper in which he described Langerhans cells, he described the granular cells in the exterior portion of the Malpighian layer of the epidermis, the stratum granulosum otherwise known as the Layer of Langerhans.
265:
throughout the gland, staining differently than the surrounding tissue. He noticed that these areas were more richly innervated, but he could not suggest a function, except for the incorrect hypothesis that they might be
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described in his paper entitled “On the nerves of the human skin,” remained an enigma for over a century before their immunological function and significance were recognised.
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in the same city. Due to his outstanding performance he was exempted from the final oral examinations. He began his medical studies at the
409:, crippling headaches and transient memory loss. Sometimes he stopped in the middle of a sentence and was unable to continue. He died of
242:
212:– CD207, langerin (Cluster of Differentiation 207) is a protein which in humans is encoded by the CD207 gene. It is expressed in the
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381:
deserve to rank as his third contribution to science. In 1887, he gave a lecture on these topics to the Royal
Academy in Berlin.
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The history of clinical endocrinology: a comprehensive account of endocrinology from earliest times to the present day
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135:, credited with the discovery of the cells that secrete insulin, named after him as the islets of Langerhans.
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In autumn of 1887, progressive renal failure brought his medical activities to an end. He developed leg
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In
February 1869, he presented a thesis entitled “Contributions to the microscopic anatomy of the
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337:, very likely because of his work in the dissecting room. In search of a cure, he travelled to
192:. From their appearance, Langerhans believed they were nerve cells. However they are a form of
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158:-producing cells. Langerhans discovered these cells during his studies for his
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Digitization (Niedersächsische Staats- und
Universitätsbibliothek Göttingen)
397:. In the words of his new bride “three indescribably happy years” followed.
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Archiv fĂĽr pathologische
Anatomie und Physiologie und fĂĽr klinische Medicin
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128:
105:
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225:
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Die Inseln des Paul
Langerhans. Eine Biographie in Bildern und Dokumenten
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on 20 July 1888, five days before his 41st birthday. He is buried in the
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The islets of Paul
Langerhans. A biography in pictures and documents
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Ein
Beitrag zur Anatomie der sympathischen Ganglienzellen
610:] (in German). Vienna: Ueberrreuter Wissenschaft.
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German military personnel of the Franco-Prussian War
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440:"Paul Langerhans (1847–1888): a centenary tribute"
252:
687:
313:, but returned to Europe at the outbreak of the
297:After graduation, he accompanied the geographer
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644:Firkin, B.G.; Whitworth, J.A., eds. (1987).
325:arranged a position for him as prosector in
281:as part of an open competition organised by
726:Physicians from the Province of Brandenburg
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558:Digitization (Bayerische Staatsbibliothek)
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243:Evangelisches Gymnasium zum Grauen Kloster
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671:. History of Medicine Series. Parthenon.
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317:and later served in an ambulance unit in
506:"Ueber die Nerven der menschlichen Haut"
444:Journal of the Royal Society of Medicine
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176:and which sometimes contain Langerhans
721:Scientists from the Kingdom of Prussia
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564:Untersuchungen ĂĽber Petromyzon-Planery
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287:branched skin cells resembling neuron,
184:to stain a sample of human skin with
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395:President of the Regional Government
120:(25 July 1847 – 20 July 1888) was a
83:Kingdom of Portugal and the Algarves
196:that were originally thought to be
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365:Consequences, Madeira and marriage
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369:In October 1875 he embarked for
241:. He later entered the renowned
172:– Skin cells concerned with the
188:and identified the cells which
706:19th-century German biologists
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349:, and underwent treatments at
253:Major scientific contributions
249:and completed them in Berlin.
237:on 25 July 1847, the son of a
16:German pathologist (1847–1888)
1:
648:Dictionary of Medical Eponyms
617:"Paul Langerhans (1847–1888)"
424:
273:One year before, still as an
164:Berlin Pathological Institute
586:Deutsche Digitale Bibliothek
570:Deutsche Digitale Bibliothek
554:Deutsche Digitale Bibliothek
7:
590:Digitization (SLUB Dresden)
415:British Cemetery of Funchal
10:
777:
741:Deaths from kidney failure
627:(2). cover. Archived from
588:(German Digital Library),
572:(German Digital Library),
556:(German Digital Library),
456:10.1177/014107688808100718
761:Burials in Madeira Island
261:,” in which he refers to
182:Julius Friedrich Cohnheim
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494:. deutsche-biographie.de
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293:Early career and disease
200:due to their morphology.
751:Prussian Army personnel
746:German military doctors
504:Langerhans, P. (1868).
438:Sakula, A (July 1988).
233:Langerhans was born in
229:Langerhans as a student
37:Paul Langerhans in 1878
716:Scientists from Berlin
331:University of Freiburg
263:islands of clear cells
230:
228:
756:German physiologists
580:Handbuch fĂĽr Madeira
327:pathological anatomy
279:epidermal skin cells
216:of Langerhans cells.
145:Islets of Langerhans
711:German pathologists
315:Franco-Prussian War
204:Layer of Langerhans
736:History of Madeira
667:Medvei VC (1993).
615:Hausen BM (2005).
602:Hausen BM (1988).
522:10.1007/BF01959006
247:University of Jena
231:
678:978-1-85070-427-0
373:on the island of
283:Berlin University
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516:(2–3): 325–337.
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170:Langerhans cells
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631:on 4 March 2016
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174:immune response
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139:Eponymous terms
118:Paul Langerhans
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633:. Retrieved
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621:Diabetologia
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335:tuberculosis
309:and western
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129:physiologist
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106:physiologist
73:(1888-07-20)
71:20 July 1888
53:25 July 1847
18:
701:1888 deaths
696:1847 births
387:meteorology
359:Switzerland
321:. In 1871,
268:lymph nodes
194:macrophages
125:pathologist
102:Pathologist
90:Nationality
690:Categories
635:12 January
425:References
355:Silvaplana
149:Pancreatic
49:1847-07-25
307:Palestine
239:physician
160:doctorate
133:biologist
110:biologist
259:pancreas
210:Langerin
178:granules
166:in 1869.
584:in the
568:in the
552:in the
530:6282875
474:3045317
465:1291675
419:Madeira
411:uraemia
375:Madeira
371:Funchal
343:Palermo
329:at the
162:at the
156:insulin
79:Funchal
61:Prussia
675:
656:
582:(1885)
566:(1873)
550:(1871)
528:
472:
462:
407:oedema
339:Naples
319:France
311:Jordan
285:. The
235:Berlin
122:German
93:German
57:Berlin
606:[
526:S2CID
401:Death
351:Davos
347:Capri
303:Syria
152:cells
673:ISBN
654:ISBN
637:2015
470:PMID
353:and
131:and
68:Died
43:Born
518:doi
460:PMC
452:doi
417:on
357:in
301:to
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625:48
623:.
619:.
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482:^
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47:(
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
