395:
372:
29:
620:
Proxymetacaine is for topical ophthalmic use only, and it is specifically not intended for injection. Prolonged use of this or any other topical ocular anesthetic may produce permanent
636:
Proxymetacaine is available as its hydrochloride salt in ophthalmic solutions at a concentration of 0.5%. Although it is no longer on patent, it is still marketed under the
669:
664:[Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese).
580:
to affect the permeability of neuronal membranes; how this inhibits pain sensations and the exact mechanism of action of proxymetacaine are, however, unknown.
78:
123:
41:
478:
754:
Murphy PJ, Ntola AM (April 2009). "Prolonged corneal anaesthesia by proxymetacaine hydrochloride detected by a thermal cooling stimulus".
1028:
832:
464:
1159:
1125:
1218:
661:
564:
Proxymetacaine is a local anesthetic which on topical application penetrates sensory nerve endings in the corneal tissue.
523:
738:
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537:
498:
1176:
1228:
825:
160:
108:
810:
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1034:
662:"RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial"
665:
390:
291:
506:
InChI=1S/C16H26N2O3/c1-4-10-20-15-8-7-13(12-14(15)17)16(19)21-11-9-18(5-2)6-3/h7-8,12H,4-6,9-11,17H2,1-3H3
351:
1203:
818:
545:
340:
191:
367:
1208:
1164:
640:
Alcaine, Ak-Taine, and others. Proparacaine 0.5% is marketed as
Poencaina by Poen Laboratories.
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1130:
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Draeger J, Langenbucher H, Bannert C (1984). "Efficacy of topical anaesthetics".
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767:
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20:
1197:
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383:
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790:"Poen-Caina generic. Price of poen-caina. Uses, Indications and Description"
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604:, or other similar procedures requiring topical anesthesia of the
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588:Proxymetacaine hydrochloride ophthalmic solution (
1195:
219:
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168:2-(diethylamino)ethyl 3-amino-4-propoxybenzoate
826:
753:
833:
819:
393:
370:
279:
27:
733:(6th ed.). New York: MacMillan Pub.
729:The Pharmacological Basis of Therapeutics
725:Goodman LS, Gilman AG, Goodman A (1980).
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583:
572:Proxymetacaine is believed to act as an
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366:
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592:) is indicated for procedures such as
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486:O=C(OCCN(CC)CC)c1ccc(OCCC)c(c1)N
424:
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756:Contact Lens & Anterior Eye
672:from the original on 2023-08-03
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511:Key:KCLANYCVBBTKTO-UHFFFAOYSA-N
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1:
1035:3-(p-Fluorobenzoyloxy)tropane
1022:ArCO2- (not para-amino or Ph)
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126:(Other controlled substances)
7:
1219:Drugs developed by Novartis
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10:
1245:
1126:Anesthetic/vasoconstrictor
768:10.1016/j.clae.2008.12.006
402:Chemical and physical data
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1031:(3,4,5-Trimethoxybenzoyl)
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762:(2): 84–7, quiz 99–100.
668:(published 2023-04-04).
52:International Drug Names
1085:Cinchocaine (Dibucaine)
847:sodium channel blockers
666:Diário Oficial da União
1229:Diethylamino compounds
1131:Bupivacaine/meloxicam
622:corneal opacification
584:Indications and usage
560:Clinical pharmacology
1136:Lidocaine/prilocaine
945:Procaine (Novocaine)
692:Ophthalmic Research
568:Mechanism of action
23:
1181:Never to phase III
624:with accompanying
550:topical anesthetic
19:
1204:Local anesthetics
1191:
1190:
1043:
1042:
842:Local anesthetics
704:10.1159/000265308
576:on voltage-gated
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465:Interactive image
352:CompTox Dashboard
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16:Chemical compound
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1171:Clinical trials
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1066:Levobupivacaine
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988:Cyclomethycaine
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925:Metabutoxycaine
920:Metabutethamine
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950:Proxymetacaine
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900:Chloroprocaine
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740:978-0023447204
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660:(2023-03-31).
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602:foreign bodies
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1075:Butanilicaine
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385:ECHA InfoCard
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36:Clinical data
34:
30:
25:
1119:Combinations
949:
940:Propoxycaine
905:Dimethocaine
872:Aminobenzoic
797:. Retrieved
793:
784:
759:
755:
749:
728:
720:
698:(3): 135–8.
695:
691:
685:
674:. Retrieved
652:
635:
632:How supplied
619:
587:
571:
563:
552:drug of the
542:proparacaine
541:
533:
532:
521:
109:Legal status
103:Legal status
1167:from market
1100:Mepivacaine
1070:Ropivacaine
1062:Bupivacaine
1013:Piperocaine
915:Meprylcaine
885:Benzonatate
845:(primarily
638:trade names
626:visual loss
610:conjunctiva
448: g·mol
391:100.007.169
152:Identifiers
1198:Categories
1146:Iontocaine
1110:Trimecaine
1105:Prilocaine
1090:Etidocaine
1080:Carticaine
1008:Isobucaine
1003:Hexylcaine
978:Amylocaine
960:Tetracaine
935:Orthocaine
930:Nitracaine
880:Benzocaine
676:2023-08-16
644:References
598:gonioscopy
574:antagonist
554:aminoester
453:3D model (
441:Molar mass
341:ChEMBL1196
301:B4OB0JHI1X
272:ChemSpider
232:IUPHAR/BPS
178:CAS Number
161:IUPAC name
143:Metabolism
1177:Phase III
1165:Withdrawn
1095:Lidocaine
1057:Articaine
1029:Amoproxan
998:β-Eucaine
993:α-Eucaine
955:Risocaine
890:Butacaine
594:tonometry
590:eye drops
192:5875-06-9
71:eye drops
60:Routes of
46:Drugs.com
1214:Anilines
895:Butamben
799:15 March
776:19181566
670:Archived
616:Warnings
524:(verify)
252:DrugBank
187:499-67-2
124:Class C1
79:ATC code
983:Cocaine
970:Benzoic
910:Lucaine
864:by acid
712:6472792
556:group.
548:) is a
446:294.395
408:Formula
261:DB00807
207:PubChem
95:)
89: (
87:S01HA04
67:Topical
1160:WHO-EM
1049:Amides
862:Esters
794:ndrugs
774:
737:
710:
658:Anvisa
606:cornea
479:SMILES
332:ChEMBL
321:D08448
147:Plasma
122:
540:) or
499:InChI
455:JSmol
853:N01B
801:2018
772:PMID
735:ISBN
708:PMID
608:and
546:USAN
312:KEGG
292:UNII
281:4766
241:7283
221:4935
137:data
42:AHFS
1141:TAC
764:doi
700:doi
538:INN
357:EPA
211:CID
196:HCl
92:WHO
1200::
1173::
792:.
770:.
760:32
758:.
706:.
696:16
694:.
628:.
612:.
596:,
422:26
416:16
118:BR
1068:/
1064:/
855:)
851:(
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834:e
827:t
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544:(
536:(
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434:3
431:O
428:2
425:N
419:H
413:C
359:)
355:(
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194:(
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69:(
44:/
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
