1039:
121:
than those genes expressed exclusively in the diploid stage is referred to as the “masking theory”. This theory implies that purifying selection is more efficient in the haploid stage of the life cycle where fitness effects are more fully expressed than in the diploid stage of the life cycle.
83:
variation, producing a decrease in the level of variation surrounding the locus under selection. The incidental purging of non-deleterious alleles due to such spatial proximity to deleterious alleles is called
76:
being the unit of selection. In such a case, carriers of the harmful point mutation have fewer offspring each generation, reducing the frequency of the mutation in the gene pool.
768:
128:. Further evidence of strong purifying selection in haploid tissue-specific genes, in support of the masking theory, has been reported for the plant,
101:. Purging by genetic drift can remove primarily deeply recessive alleles, whereas natural selection can remove any type of deleterious alleles.
725:
565:
512:
Gerstein AC, Cleathero LA, Mandegar MA, Otto SP (March 2011). "Haploids adapt faster than diploids across a range of environments".
79:
In the case of strong negative selection on a locus, the purging of deleterious variants will result in the occasional removal of
1080:
1018:
773:
31:
17:
718:
636:
558:
813:
1054:
818:
181:
1109:
748:
711:
1104:
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551:
692:
465:"Strong Purifying Selection in Haploid Tissue-Specific Genes of Scots Pine Supports the Masking Theory"
914:
788:
207:
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124:
1114:
778:
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631:
90:. This effect increases with lower mutation rate but decreases with higher recombination rate.
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62:
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Cervantes S, Kesälahti R, Kumpula TA, Mattila TM, Helanterä H, Pyhäjärvi T (August 2023).
8:
995:
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118:
54:
38:
307:
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Evidence supporting the masking theory has been reported in the single-celled yeast
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231:"Inbreeding depression and purging in a haplodiploid: gender-related effects"
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956:
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299:
264:
104:
405:
356:
646:
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Gulisija D, Crow JF (May 2007). "Inferring purging from pedigree data".
703:
543:
961:
421:"How are deleterious mutations purged? Drift versus nonrandom mating"
161:
323:"The effect of deleterious mutations on neutral molecular variation"
93:
Purifying selection can be split into purging by non-random mating (
1046:
1038:
50:
462:
114:
320:
511:
110:
321:
Charlesworth B, Morgan MT, Charlesworth D (August 1993).
105:
Negative selection in haploid compared to diploid tissue
68:
Purging of deleterious alleles can be achieved on the
425:
Evolution; International
Journal of Organic Evolution
372:"Deleterious background selection with recombination"
280:
Evolution; International
Journal of Organic Evolution
27:Selective removal of alleles that are deleterious
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1074:
719:
559:
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369:
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1067:
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229:Tien NS, Sabelis MW, Egas M (March 2015).
488:
436:
395:
346:
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113:of an organism that are expressed in the
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573:
14:
1092:
1019:Index of evolutionary biology articles
418:
370:Hudson RR, Kaplan NL (December 1995).
707:
547:
205:
65:that arise through random mutations.
1033:
61:through the purging of deleterious
32:Negative selection (disambiguation)
24:
438:10.1111/j.0014-3820.2003.tb01512.x
72:level, with as little as a single
25:
1126:
637:Models of nucleotide substitution
1037:
526:10.1111/j.1420-9101.2010.02188.x
292:10.1111/j.1558-5646.2007.00088.x
117:stage are under more efficient
819:Constructive neutral evolution
505:
412:
363:
314:
199:
13:
1:
192:
1053:. You can help Knowledge by
769:Fisher's fundamental theorem
49:is the selective removal of
7:
794:Coefficient of relationship
388:10.1093/genetics/141.4.1605
339:10.1093/genetics/134.4.1289
135:
10:
1131:
1032:
693:Nonsynonymous substitution
419:Glémin S (December 2003).
182:Mutation–selection balance
29:
1014:
949:
923:
885:
860:
827:
789:Coefficient of inbreeding
741:
665:
624:
581:
967:Evolutionary game theory
749:Hardy–Weinberg principle
125:Saccharomyces cerevisiae
779:Shifting balance theory
688:Synonymous substitution
632:Models of DNA evolution
764:Linkage disequilibrium
481:10.1093/molbev/msad183
1006:Quantitative genetics
915:Balding–Nichols model
900:Population bottleneck
895:Small population size
799:Selection coefficient
611:Stabilizing selection
596:Directional selection
187:Stabilizing selection
167:Fluctuating selection
152:Directional selection
63:genetic polymorphisms
59:stabilising selection
57:. This can result in
877:Background selection
864:on genomic variation
862:Effects of selection
814:Population structure
601:Disruptive selection
247:10.1038/hdy.2014.106
208:"Negative selection"
157:Disruptive selection
109:The idea that those
87:background selection
30:For other uses, see
1110:Population genetics
996:Population genomics
872:Genetic hitchhiking
759:Identity by descent
735:Population genetics
666:Molecular processes
591:Balancing selection
575:Molecular evolution
147:Balancing selection
70:population genetics
47:purifying selection
18:Purifying selection
1105:Classical genetics
982:Landscape genetics
606:Negative selection
142:Assortative mating
95:assortative mating
43:negative selection
1062:
1061:
1027:
1026:
977:Genetic genealogy
972:Fitness landscape
701:
700:
583:Natural selection
119:natural selection
97:) and purging by
39:natural selection
16:(Redirected from
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1083:
1076:
1069:
1041:
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936:J. B. S. Haldane
728:
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678:Gene duplication
642:Allele frequency
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212:Nature Education
206:Loewe L (2008).
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754:Genetic linkage
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683:Silent mutation
673:Gene conversion
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616:Selective sweep
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431:(12): 2678–87.
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333:(4): 1289–303.
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172:Genetic purging
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1001:Phylogeography
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991:Microevolution
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950:Related topics
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905:Founder effect
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784:Price equation
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774:Neutral theory
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382:(4): 1605–17.
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941:Sewall Wright
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887:Genetic drift
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520:(3): 531–40.
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469:Mol Biol Evol
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241:(3): 327–32.
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99:genetic drift
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1055:expanding it
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957:Biogeography
931:R. A. Fisher
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809:Heritability
742:Key concepts
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42:
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910:Coalescence
647:Ka/Ks ratio
514:J Evol Biol
177:Koinophilia
55:deleterious
1094:Categories
852:Ecological
842:Artificial
652:Tajima's D
193:References
130:Scots Pine
1100:Selection
962:Evolution
829:Selection
162:Dysgenics
53:that are
1047:genetics
986:genomics
924:Founders
534:21159002
499:37565532
490:10457172
447:14761049
376:Genetics
327:Genetics
308:24302475
300:17492959
265:25407077
235:Heredity
218:(1): 59.
136:See also
837:Natural
804:Fitness
406:8601498
397:1206891
357:8375663
348:1205596
256:4815584
115:haploid
51:alleles
847:Sexual
625:Models
532:
497:
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306:
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263:
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81:linked
1045:This
475:(8).
304:S2CID
111:genes
1051:stub
984:and
530:PMID
495:PMID
443:PMID
402:PMID
353:PMID
296:PMID
261:PMID
522:doi
485:PMC
477:doi
433:doi
392:PMC
384:doi
380:141
343:PMC
335:doi
331:134
288:doi
251:PMC
243:doi
239:114
45:or
37:In
1096::
528:.
518:24
516:.
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483:.
473:40
471:.
467:.
455:^
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429:57
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41:,
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216:1
34:.
20:)
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