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is a set of regulons or operons that are collectively regulated in response to changes in overall conditions or stresses, but may be under the control of different or overlapping regulatory molecules. The term
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behavior in bacteria is a commonly cited example of a modulon or stimulon, though some sources describe this type of intercellular auto-induction as a separate form of regulation.
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Lengeler, Joseph W.; Postma, P.W. (1999). "Global
Regulatory Networks and Signal Transduction Pathways". In Lengeler, Joseph W.; Drews, Gerhart; Schlegel, Hans G. (eds.).
504:"Bacterial regulon evolution: distinct responses and roles for the identical OmpR proteins of Salmonella Typhimurium and Escherichia coli in the acid stress response"
297:"Regulon and promoter analysis of the E. coli heat-shock factor, sigma32, reveals a multifaceted cellular response to heat stress"
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428:"Regulatory responses of the adaptive response to alkylation damage: a simple regulon with complex regulatory features"
346:"The phosphate regulon and bacterial virulence: a regulatory network connecting phosphate homeostasis and pathogenesis"
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75:; the genes contained within a regulon are usually organized into more than one operon at disparate locations on the
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is sometimes used to refer to the set of genes whose expression responds to specific environmental stimuli.
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387:"Pathogenicity islands of virulent bacteria: structure, function and impact on microbial evolution"
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Commonly studied regulons in bacteria are those involved in response to stress such as
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bacteria are of particular research interest; an often-studied example is the
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Nonaka, G; Blankschien, M; Herman, C; Gross, CA; Rhodius, VA (1 July 2006).
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is a well-characterized example of a group of genes involved in the
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Hacker, J; Blum-Oehler, G; Mühldorfer, I; Tschäpe, H (March 1997).
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Lamarche, MG; Wanner, BL; Crépin, S; Harel, J (May 2008).
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481:. Springer Science & Business Media. p. 66.
16:"Modulon" redirects here. For the spasmolytic, see
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502:Quinn, HJ; Cameron, AD; Dorman, CJ (March 2014).
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475:Michael Hecker; Stefan Müllner (18 July 2003).
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43:as a unit, generally controlled by the same
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558:at the U.S. National Library of Medicine
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426:Landini, P; Volkert, MR (December 2000).
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197:are a common mechanism for prokaryotic
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226:environments in the close relative
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20:. For the birth control pill, see
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222:but is involved in response to
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193:Changes in the regulation of
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154:. Regulons can sometimes be
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150:to pathogenicity through a
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256:Biology of the prokaryotes
146:, which couples phosphate
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350:FEMS Microbiology Reviews
71:are often organized into
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283:Medical Subject Headings
432:Journal of Bacteriology
301:Genes & Development
391:Molecular Microbiology
156:pathogenicity islands
152:two-component system
113:is regulated by the
313:10.1101/gad.1428206
207:DNA-binding protein
128:Regulons involving
123:open reading frames
29:molecular genetics
488:978-3-540-00546-9
173:adaptive response
138:phosphate regulon
130:virulence factors
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163:Ada regulon
148:homeostasis
65:prokaryotes
237:References
229:Salmonella
216:stress in
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177:DNA repair
134:pathogenic
105:heat shock
81:eukaryotes
77:chromosome
199:evolution
189:Evolution
61:activator
57:repressor
49:expresses
41:regulated
39:that are
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175:form of
99:Examples
93:stimulon
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556:Regulon
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279:Regulon
219:E. coli
214:osmotic
168:E. coli
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88:modulon
73:operons
69:genomes
53:protein
33:regulon
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224:acidic
117:σ32 (
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37:genes
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368:PMID
327:PMID
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210:OmpR
161:The
119:RpoH
31:, a
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