487:
478:
469:
35:
299:
292:
48:
193:
339:
322:
255:
273:
228:
233:
208:
618:
Bui AM, Cavé A, Janot MM, Parello J, Potier P, Scheidegger U (1974-01-01). "Isolement et analyse structurale du collybolide, nouveau sesquiterpene extrait de
Collybia maculata alb. et sch. ex fries (basidiomycetes)" [Isolation and structural analysis of collybolide, a new sesquiterpene extracted
802:
395:
The cap is cream-colored with red-brown spots. The edge remains inrolled for an extended period of time. The whitish gills are crowded, becoming spotted in age. The similarly colored stipe is long, tough, hollow, and tapered downwards.
452:
extracts by other groups additionally showed no KOR activity. These assays of synthetic and natural samples contradict the findings of Gupta et al., and suggest that collybolide and the other constituents of
433:, collybolide garnered attention in the synthetic chemistry and pharmacology fields as a potential scaffold for developing next-generation analgesics, antipruritics, and antidepressants.
368:
440:
completed the first enantioselective total synthesis of collybolide and profiled the activity of synthetic collybolide at the KOR. Despite previous findings by Gupta
429:
reported that collybolide exhibited high-potency, selective kappa-opioid receptor (KOR) agonism. Due to its attractive bioactivity and chemical similarity to
1267:
444:, these assays showed that neither enantiomer of collybolide had KOR activity. The synthetic sample was identical to natural collybolide isolated from
959:
537:
1272:
1090:
803:"A systematic review on the kappa opioid receptor and its ligands: New directions for the treatment of pain, anxiety, depression, and drug abuse"
1142:
192:
1064:
703:
670:
602:
411:
Though non-toxic, this species is considered inedible due to its toughness and unpalatability; it is typically bitter.
853:"Natural Products for the Treatment of Pain: Chemistry and Pharmacology of Salvinorin A, Mitragynine, and Collybolide"
1147:
1257:
1129:
47:
549:
1234:
1211:
1157:
1056:
1121:
1277:
720:
1262:
1095:
970:
744:"Collybolide is a novel biased agonist of Îş-opioid receptors with potent antipruritic activity"
695:
142:
1170:
564:
1025:
755:
8:
654:
759:
933:
904:
877:
852:
833:
778:
743:
688:
214:
164:
42:
742:
Gupta A, Gomes I, Bobeck EN, Fakira AK, Massaro NP, Sharma I, et al. (May 2016).
632:
1165:
1012:
938:
882:
837:
825:
783:
699:
666:
636:
598:
238:
486:
477:
468:
1017:
928:
920:
872:
864:
817:
773:
763:
628:
278:
34:
1197:
821:
592:
345:
1134:
868:
1206:
1051:
993:
924:
748:
Proceedings of the
National Academy of Sciences of the United States of America
89:
1251:
640:
372:
119:
109:
79:
768:
942:
886:
829:
787:
430:
403:
is characterized by yellowish color of its gills, and sometimes the stipe.
384:
329:
903:
Shevick SL, Freeman SM, Tong G, Russo RJ, Bohn LM, Shenvi RA (July 2022).
1116:
1077:
1004:
905:"Asymmetric Syntheses of (+)- and (-)-Collybolide Enable Reevaluation of
662:
420:
380:
305:
1069:
99:
1082:
597:. Timber Press Field Guides. Portland, OR: Timber Press. p. 120.
383:, a sesquiterpenoid containing a furyl-áşź-lactone motif reminiscent of
1224:
1108:
1038:
619:
from
Collybia maculata alb. and sch. ex fries (basidiomycetes)].
59:
964:
659:
North
American Mushrooms: A Field Guide to Edible and Inedible Fungi
1219:
1191:
1103:
1043:
987:
260:
219:
198:
1030:
69:
511:
for reports on the kappa-opioid receptor assays with crude
902:
741:
507:
See page 150 of the
Supporting Information of Shevick
801:
Khan MI, Sawyer BJ, Akins NS, Le HV (December 2022).
850:
617:
687:
800:
1249:
414:
375:. It often appears in decomposing conifer duff.
653:
590:
1268:Taxa named by Johannes Baptista von Albertini
712:
690:Mushrooms and Other Fungi of North America
647:
33:
932:
876:
777:
767:
685:
1273:Taxa named by Lewis David de Schweinitz
810:European Journal of Medicinal Chemistry
718:
1250:
851:Chakraborty S, Majumdar S (May 2021).
694:. Buffalo, NY: Firefly Books. p.
501:
969:
968:
898:
896:
1235:0985d8c1-1b18-4d25-be68-66abfb1fc3d3
1158:877090ae-536f-40a7-adb9-871c75d8f0e0
586:
584:
582:
562:
13:
893:
594:Mushrooms of the Pacific Northwest
542:(Alb. & Schwein.: Fr.) Singer"
14:
1289:
953:
579:
535:
158:(Alb. & Schwein.: Fr.) Singer
485:
476:
467:
337:
320:
297:
290:
271:
253:
231:
226:
206:
191:
46:
844:
794:
735:
679:
611:
591:Trudell S, Ammirati J (2009).
556:
529:
390:
1:
633:10.1016/S0040-4020(01)97243-6
522:
415:Kappa-opioid receptor agonism
822:10.1016/j.ejmech.2022.114785
406:
7:
869:10.1021/acs.biochem.0c00629
199:Mycological characteristics
10:
1294:
925:10.1021/acscentsci.2c00442
460:
418:
1181:
977:
909:-Opioid Receptor Agonism"
457:have no activity at KOR.
344:Edibility is edible, but
336:
319:
288:
270:
252:
225:
205:
186:
170:
163:
148:
141:
43:Scientific classification
41:
32:
25:
546:Arizona State University
494:
769:10.1073/pnas.1521825113
729:The Fungi of California
1258:Fungi of North America
979:Rhodocollybia maculata
723:Rhodocollybia maculata
567:Rhodocollybia maculata
540:Rhodocollybia maculata
363:commonly known as the
359:Rhodocollybia maculata
188:Rhodocollybia maculata
152:Rhodocollybia maculata
27:Rhodocollybia maculata
371:fungus in the family
657:, Miller HH (2006).
563:Kuo M (March 2018).
913:ACS Central Science
760:2016PNAS..113.6041G
719:Wood M, Stevens F.
686:Phillips R (2010).
399:A variety known as
1183:Agaricus maculatus
573:MushroomExpert.Com
367:, is a species of
365:spotted toughshank
1245:
1244:
1166:Open Tree of Life
971:Taxon identifiers
863:(18): 1381–1400.
754:(21): 6041–6046.
705:978-1-55407-651-2
672:978-0-7627-3109-1
627:(11): 1327–1336.
604:978-0-88192-935-5
436:In 2022, Shevick
353:
352:
181:Species of fungus
179:
178:
173:Collybia maculata
16:Species of fungus
1285:
1238:
1237:
1228:
1227:
1215:
1214:
1202:
1201:
1200:
1174:
1173:
1161:
1160:
1151:
1150:
1138:
1137:
1135:NHMSYS0001496346
1125:
1124:
1112:
1111:
1099:
1098:
1086:
1085:
1073:
1072:
1060:
1059:
1047:
1046:
1034:
1033:
1021:
1020:
1008:
1007:
998:
997:
996:
966:
965:
947:
946:
936:
900:
891:
890:
880:
848:
842:
841:
807:
798:
792:
791:
781:
771:
739:
733:
732:
716:
710:
709:
693:
683:
677:
676:
661:. Guilford, CN:
651:
645:
644:
615:
609:
608:
588:
577:
576:
560:
554:
553:
548:. Archived from
533:
516:
505:
489:
480:
471:
448:Assays of crude
341:
340:
324:
323:
301:
300:
294:
293:
275:
274:
257:
256:
235:
234:
230:
229:
210:
209:
195:
184:
183:
154:
134:R. maculata
51:
50:
37:
23:
22:
1293:
1292:
1288:
1287:
1286:
1284:
1283:
1282:
1248:
1247:
1246:
1241:
1233:
1231:
1223:
1218:
1210:
1205:
1196:
1195:
1190:
1177:
1169:
1164:
1156:
1154:
1146:
1141:
1133:
1128:
1120:
1115:
1107:
1102:
1094:
1089:
1081:
1076:
1068:
1063:
1055:
1050:
1042:
1037:
1029:
1024:
1016:
1011:
1003:
1001:
992:
991:
986:
973:
956:
951:
950:
901:
894:
849:
845:
805:
799:
795:
740:
736:
717:
713:
706:
684:
680:
673:
665:. p. 176.
652:
648:
616:
612:
605:
589:
580:
561:
557:
534:
530:
525:
520:
519:
506:
502:
497:
490:
481:
472:
463:
425:In 2016, Gupta
423:
417:
409:
393:
379:is a source of
355:
354:
338:
321:
302:
298:
295:
291:
272:
254:
232:
227:
207:
201:
196:
182:
159:
156:
150:
137:
45:
17:
12:
11:
5:
1291:
1281:
1280:
1278:Fungus species
1275:
1270:
1265:
1260:
1243:
1242:
1240:
1239:
1229:
1216:
1203:
1187:
1185:
1179:
1178:
1176:
1175:
1162:
1152:
1139:
1126:
1113:
1100:
1087:
1074:
1061:
1048:
1035:
1022:
1009:
999:
983:
981:
975:
974:
963:
962:
955:
954:External links
952:
949:
948:
919:(7): 948–954.
892:
843:
793:
734:
711:
704:
678:
671:
646:
610:
603:
578:
555:
552:on 2012-03-31.
527:
526:
524:
521:
518:
517:
499:
498:
496:
493:
492:
491:
484:
482:
475:
473:
466:
462:
459:
419:Main article:
416:
413:
408:
405:
392:
389:
351:
350:
342:
334:
333:
325:
317:
316:
303:
296:
289:
286:
285:
276:
268:
267:
258:
250:
249:
236:
223:
222:
211:
203:
202:
197:
190:
180:
177:
176:
168:
167:
161:
160:
157:
146:
145:
139:
138:
131:
129:
125:
124:
117:
113:
112:
107:
103:
102:
97:
93:
92:
90:Agaricomycetes
87:
83:
82:
77:
73:
72:
67:
63:
62:
57:
53:
52:
39:
38:
30:
29:
19:
18:
15:
9:
6:
4:
3:
2:
1290:
1279:
1276:
1274:
1271:
1269:
1266:
1264:
1263:Rhodocollybia
1261:
1259:
1256:
1255:
1253:
1236:
1230:
1226:
1221:
1217:
1213:
1208:
1204:
1199:
1193:
1189:
1188:
1186:
1184:
1180:
1172:
1167:
1163:
1159:
1153:
1149:
1144:
1140:
1136:
1131:
1127:
1123:
1118:
1114:
1110:
1105:
1101:
1097:
1092:
1088:
1084:
1079:
1075:
1071:
1066:
1062:
1058:
1053:
1049:
1045:
1040:
1036:
1032:
1027:
1023:
1019:
1014:
1010:
1006:
1000:
995:
989:
985:
984:
982:
980:
976:
972:
967:
961:
958:
957:
944:
940:
935:
930:
926:
922:
918:
914:
910:
908:
899:
897:
888:
884:
879:
874:
870:
866:
862:
858:
854:
847:
839:
835:
831:
827:
823:
819:
815:
811:
804:
797:
789:
785:
780:
775:
770:
765:
761:
757:
753:
749:
745:
738:
730:
726:
724:
715:
707:
701:
697:
692:
691:
682:
674:
668:
664:
660:
656:
650:
642:
638:
634:
630:
626:
623:(in French).
622:
614:
606:
600:
596:
595:
587:
585:
583:
574:
570:
568:
559:
551:
547:
543:
541:
532:
528:
514:
510:
504:
500:
488:
483:
479:
474:
470:
465:
464:
458:
456:
451:
447:
443:
439:
434:
432:
428:
422:
412:
404:
402:
397:
388:
386:
382:
378:
374:
373:Omphalotaceae
370:
369:basidiomycete
366:
362:
360:
349:
348:
343:
335:
332:
331:
326:
318:
315:
311:
307:
304:
287:
284:
280:
277:
269:
266:
262:
259:
251:
248:
244:
240:
237:
224:
221:
217:
216:
212:
204:
200:
194:
189:
185:
175:
174:
169:
166:
162:
155:
153:
147:
144:
143:Binomial name
140:
136:
135:
130:
127:
126:
123:
122:
121:Rhodocollybia
118:
115:
114:
111:
110:Omphalotaceae
108:
105:
104:
101:
98:
95:
94:
91:
88:
85:
84:
81:
80:Basidiomycota
78:
75:
74:
71:
68:
65:
64:
61:
58:
55:
54:
49:
44:
40:
36:
31:
28:
24:
21:
1182:
978:
916:
912:
906:
860:
857:Biochemistry
856:
846:
813:
809:
796:
751:
747:
737:
728:
722:
714:
689:
681:
658:
655:Miller Jr OK
649:
624:
620:
613:
593:
572:
566:
558:
550:the original
545:
539:
531:
512:
508:
503:
454:
449:
446:R. maculata.
445:
441:
437:
435:
431:salvinorin A
426:
424:
410:
400:
398:
394:
385:salvinorin A
376:
364:
358:
357:
356:
346:
330:saprotrophic
328:
313:
309:
282:
264:
246:
242:
213:
187:
172:
171:
151:
149:
133:
132:
120:
26:
20:
1117:NatureServe
1078:iNaturalist
663:FalconGuide
621:Tetrahedron
513:R. maculata
455:R. maculata
450:R. maculata
421:Collybolide
401:scorzonerea
391:Description
381:collybolide
377:R. maculata
347:unpalatable
327:Ecology is
306:Spore print
1252:Categories
816:: 114785.
536:Bates ST.
523:References
100:Agaricales
76:Division:
1198:Q61857864
838:252476850
641:0040-4020
515:extracts.
407:Edibility
128:Species:
66:Kingdom:
60:Eukaryota
1220:MycoBank
1207:Fungorum
1192:Wikidata
1122:2.921229
1104:MycoBank
1096:11280085
1052:Fungorum
1002:BioLib:
994:Q2645787
988:Wikidata
943:35912357
887:32930582
830:36179400
788:27162327
261:Hymenium
220:hymenium
165:Synonyms
106:Family:
56:Domain:
1070:3321205
1031:6680243
934:9335922
878:7982354
779:4889365
756:Bibcode
461:Gallery
265:adnexed
116:Genus:
96:Order:
86:Class:
1232:NZOR:
1225:190275
1212:190275
1171:388473
1155:NZOR:
1109:253156
1083:118168
1057:253156
1044:COLYMA
960:Images
941:
931:
885:
875:
836:
828:
786:
776:
702:
669:
639:
601:
509:et al.
442:et al.
438:et al.
427:et al.
243:convex
1148:71918
1091:IRMNG
1018:4SF59
1005:60326
907:kappa
834:S2CID
806:(PDF)
495:Notes
314:cream
279:Stipe
215:Gills
70:Fungi
1143:NCBI
1065:GBIF
1039:EPPO
939:PMID
883:PMID
826:PMID
784:PMID
700:ISBN
667:ISBN
637:ISSN
599:ISBN
310:pink
283:bare
247:flat
1130:NBN
1026:EoL
1013:CoL
929:PMC
921:doi
873:PMC
865:doi
818:doi
814:243
774:PMC
764:doi
752:113
629:doi
312:to
308:is
281:is
263:is
245:or
241:is
239:Cap
218:on
1254::
1222::
1209::
1194::
1168::
1145::
1132::
1119::
1106::
1093::
1080::
1067::
1054::
1041::
1028::
1015::
990::
937:.
927:.
915:.
911:.
895:^
881:.
871:.
861:60
859:.
855:.
832:.
824:.
812:.
808:.
782:.
772:.
762:.
750:.
746:.
727:.
698:.
696:73
635:.
625:30
581:^
571:.
544:.
387:.
945:.
923::
917:8
889:.
867::
840:.
820::
790:.
766::
758::
731:.
725:"
721:"
708:.
675:.
643:.
631::
607:.
575:.
569:"
565:"
538:"
361:,
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
