Selective serotonin reuptake inhibitor

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significance. Moreover, this method can exaggerate small differences between interventions such as antidepressants and placebo , and statisticians note that it can distort data and should be avoided , . Response rates in double-blind antidepressant trials are typically about 50% in the drug groups and 35% in the placebo groups (e.g., , ). This 15% difference is often defended as clinically significant on the grounds that 15% of depressed people who get better on antidepressants would not have gotten better on placebo. However, a 50% reduction in symptoms is close to the mean and median of drug improvement rates in placebo-controlled antidepressant trials , , and thus near the apex of the distribution curve. Thus, with an SD of 8 in change scores, a 15% difference in response rates is about (an odds ratio of 1.86, a relative risk of 0.77, and an NNT of 7) is exactly what one would expect from a mean 3-point difference in HAM-D scores . Lack of response does not mean that the patient has not improved; it means that the improvement has been less, by as little as one point, than the arbitrary criterion chosen for defining a therapeutic response.

793:. There are limited treatment options for PSSD as of 2023 and no evidence that any individual approach is effective. The mechanism by which SRIs may induce PSSD is unclear; neurobiological and cognitive factors may act in combination to cause the problem. As of 2023, prevalence is unknown. A 2020 review stated that PSSD is rare, underreported, and "increasingly identified in online communities". A 2024 study investigating the prevalence of persistent post-treatment genital numbness among sexual and gender minority youth found 13.2% of SSRI users between the ages 15 and 29 reporting the symptom compared to 0.9% who had used other medications. 2650: 1283:. It is associated with about a 25% risk of significant long-term neurological deficits. A 2014 meta analysis found no increased risk of persistent pulmonary hypertension associated with exposure to SSRI's in early pregnancy and a slight increase in risk associates with exposure late in pregnancy; "an estimated 286 to 351 women would need to be treated with an SSRI in late pregnancy to result in an average of one additional case of persistent pulmonary hypertension of the newborn". A review published in 2012 reached conclusions very similar to those of the 2014 study. 820:... which was long lasting in rare cases", but recommended that "healthcare professionals inform patients about the potential risk of long-lasting sexual dysfunction despite discontinuation of treatment". A 2023 review stated that ongoing sexual dysfunction after SSRI discontinuation was possible, but that cause and effect were undetermined. The 2023 review cautioned that reports of sexual dysfunction cannot be generalized to wider practice as they are subject to a "high risk of bias", but agreed with the EMA assessment that cautionary labeling on SSRIs was warranted. 2767: 2977: 3007: 1806:. Paroxetine may produce discontinuation-related symptoms at a greater rate than other SSRIs, though qualitatively similar effects have been reported for all SSRIs. Discontinuation effects appear to be less for fluoxetine, perhaps owing to its long half-life and the natural tapering effect associated with its slow clearance from the body. One strategy for minimizing SSRI discontinuation symptoms is to switch the patient to fluoxetine and then taper and discontinue the fluoxetine. 1113:

treatment". The European Psychiatric Association places the excess risk in the first two weeks of treatment and, based on a combination of epidemiological, prospective cohort, medical claims, and randomized clinical trial data, concludes that a protective effect dominates after this early period. A 2014 Cochrane review found that at six to nine months, suicidal ideation remained higher in children treated with antidepressants compared to those treated with psychological therapy.

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of these drugs. To investigate the apparent anti-inflammatory effects of SSRIs, both Kohler et al. and Więdłocha et al. conducted meta-analyses which have shown that after antidepressant treatment the levels of cytokines associated with inflammation are decreased. A large cohort study conducted by researchers in the Netherlands investigated the association between depressive disorders, symptoms, and antidepressants with inflammation. The study showed decreased levels of

58: 2737: 2757: 3047: 3017: 2987: 2997: 2882: 2777: 3027: 2819: 2747: 2727: 3037: 2872: 1071:, an enzyme which is needed to break down serotonin and other neurotransmitters. Without monoamine oxidase, the body is unable to eliminate excess neurotransmitters, allowing them to build up to dangerous levels. The prognosis for recovery in a hospital setting is generally good if serotonin syndrome is correctly identified. Treatment consists of discontinuing any serotonergic drugs and providing supportive care to manage 481:(OCD). In the UK, they are first-line treatment only with moderate to severe functional impairment and as second line treatment for those with mild impairment, though, as of early 2019, this recommendation is being reviewed. In children, SSRIs can be considered a second line therapy in those with moderate-to-severe impairment, with close monitoring for psychiatric adverse effects. SSRIs, especially 362:

risk of both serious and non-serious adverse events. Our results show that the harmful effects of SSRIs versus placebo for major depressive disorder seem to outweigh any potentially small beneficial effects". Fredrik Hieronymus et al. criticized the review as inaccurate and misleading, but they also disclosed multiple ties to pharmaceutical industries and receipt of speaker's fees.

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than sertraline, but both are not fully effective for many patients. Fluoxetine is used off-label, but with mixed results; venlafaxine, an SNRI, is considered somewhat effective, although its use is also off-label. Fluvoxamine, escitalopram and citalopram are not well tested in this disorder. Paroxetine remains the most suitable drug for PTSD as of now, but with limited benefits.

466:(GAD) that has failed to respond to conservative measures such as education and self-help activities. GAD is a common disorder of which the central feature is excessive worry about a number of different events. Key symptoms include excessive anxiety about multiple events and issues, and difficulty controlling worrisome thoughts, that persists for at least 6 months. 1239:

of cardiovascular birth defects among depressed mothers not undergoing SSRI treatment, suggesting the possibility of ascertainment bias, e.g. that worried mothers may pursue more aggressive testing of their infants. Another study found no increase in cardiovascular birth defects and a 27% increased risk of major malformations in SSRI exposed pregnancies.

485:, which is the first one to be FDA approved for OCD, are efficacious in its treatment; patients treated with SSRIs are about twice as likely to respond to treatment as those treated with placebo. Efficacy has been demonstrated both in short-term treatment trials of 6 to 24 weeks and in discontinuation trials of 28 to 52 weeks duration. 354:). The authors attributed the relationship between severity and efficacy to a reduction of the placebo effect in severely depressed patients, rather than an increase in the effect of the medication. Some researchers have questioned the statistical basis of this study suggesting that it underestimates the effect size of antidepressants. 530:. Treatment guidelines from the National Institute of Health and Clinical Excellence recommend against the use of SSRIs in this disorder. Those from the American Psychiatric Association note that SSRIs confer no advantage regarding weight gain, but that they may be used for the treatment of co-existing depression, anxiety, or OCD. 711:(SRI) drugs, in which sexual dysfunction symptoms persist for at least three months after ceasing to take the drug. The status of PSSD as a legitimate and distinct pathology is contentious; several researchers have proposed that it should be recognized as a separate phenomenon from more common SSRI side effects. 895:(CHD) in those without a previous diagnosis of CHD. A large cohort study suggested no substantial increase in the risk of cardiac malformations attributable to SSRI usage during the first trimester of pregnancy. A number of large studies of people without known pre-existing heart disease have reported no 2191:

SSRIs were originally invented with the goal of increasing levels of available serotonin in the extracellular spaces. However, the delayed response between when patients first begin SSRI treatment to when they see effects has led scientists to believe that other molecules are involved in the efficacy

1872:

transporters within the brain and through this slow downstream changes of large brain regions at therapeutic concentrations, whereas MDMA leads to an excess serotonin release in a short run. This could explain the absence of a "high" by antidepressants and in addition the contrary ability of SSRIs in

1327:, the risk of switching may be twice or three times that of the average. The changes are not often easy to detect and require monitoring by family and mental health professionals. This switch might happen even with no prior (hypo)manic episodes and might therefore not be foreseen by the psychiatrist. 989:

therapy. However, because the relationship between SSRIs and fractures is based on observational data as opposed to prospective trials, the phenomenon is not definitively causal. There also appears to be an increase in fracture-inducing falls with SSRI use, suggesting the need for increased attention

633:

The mechanism by which SSRIs may cause sexual side effects is not well understood as of 2021. The range of possible mechanisms includes (1) nonspecific neurological effects (e.g., sedation) that globally impair behavior including sexual function; (2) specific effects on brain systems mediating sexual

1741:

Another important interaction of certain SSRIs involves paroxetine, a potent inhibitor of CYP2D6, and tamoxifen, an agent used commonly in the treatment and prevention of breast cancer. Tamoxifen is a prodrug that is metabolised by the hepatic cytochrome P450 enzyme system, especially CYP2D6, to its

1760:

when compared with traditional antidepressants, such as the tricyclic antidepressants. This relative safety is supported both by case series and studies of deaths per numbers of prescriptions. However, case reports of SSRI poisoning have indicated that severe toxicity can occur and deaths have been

1299:)" even though a large cohort study published in 2013 and a cohort study using data from Finland's national register between the years 1996 and 2010 and published in 2016 found no significant association between SSRI use and autism in offspring. The 2016 Finland study also found no association with 1238:

A systematic review of the risk of major birth defects in antidepressant-exposed pregnancies found a small increase (3% to 24%) in the risk of major malformations and a risk of cardiovascular birth defects that did not differ from non-exposed pregnancies. Other studies have found an increased risk

1116:

A recent comparison of aggression and hostility occurring during treatment with fluoxetine to placebo in children and adolescents found that no significant difference between the fluoxetine group and a placebo group. There is also evidence that higher rates of SSRI prescriptions are associated with

1112:

and suicidal behavior" by about 80%, and of agitation and hostility by about 130%. According to the FDA, the heightened risk of suicidality is within the first one to two months of treatment. The National Institute for Health and Care Excellence (NICE) places the excess risk in the "early stages of

329:

Two meta-analyses published in 2008 (Kirsch) and 2010 (Fournier) found that in mild and moderate depression, the effect of SSRIs is small or none compared to placebo, while in very severe depression the effect of SSRIs is between "relatively small" and "substantial". The 2008 meta-analysis combined

5942:

Healy D, Bahrick A, Bak M, Barbato A, Calabrò RS, Chubak BM, Cosci F, Csoka AB, D'Avanzo B, Diviccaro S, Giatti S, Goldstein I, Graf H, Hellstrom WJ, Irwig MS, Jannini EA, Janssen PK, Khera M, Kumar MT, Le Noury J, Lew-Starowicz M, Linden DE, Lüning C, Mangin D, Melcangi RC, Rodríguez OW, Panicker

4094:

Another common flaw is to report efficacy based on drug-placebo differences in response and remission rates (27). To come at binary constructs such as response and remission, continuous symptom rating scales are dichotomized along arbitrary cut-offs. However, methodologists have vigorously advised

1174:

A 2006 review suggests that the widespread use of antidepressants in the new "SSRI-era" appears to have led to a highly significant decline in suicide rates in most countries with traditionally high baseline suicide rates. The decline is particularly striking for women who, compared with men, seek

361:

A 2017 systematic review stated that "SSRIs versus placebo seem to have statistically significant effects on depressive symptoms, but the clinical significance of these effects seems questionable and all trials were at high risk of bias. Furthermore, SSRIs versus placebo significantly increase the

2223:

can induce an inflammatory response in microglia and can cause neuroinflammation. SSRIs inhibit proinflammatory cytokine production which leads to less activation of microglia and peripheral macrophages. SSRIs not only inhibit the production of these proinflammatory cytokines, they also have been

2163:

The role of inflammation and the immune system in depression has been extensively studied. The evidence supporting this link has been shown in numerous studies over the past ten years. Nationwide studies and meta-analyses of smaller cohort studies have uncovered a correlation between pre-existing

1186:

An additional meta-analysis by the FDA in 2006 found an age-related effect of SSRI's. Among adults younger than 25 years, results indicated that there was a higher risk for suicidal behavior. For adults between 25 and 64, the effect appears neutral on suicidal behavior but possibly protective for

453:

is relatively hard to treat and generally treatment is not highly effective; SSRIs are no exception. They are not very effective for this disorder and only two SSRI are FDA approved for this condition: paroxetine and sertraline. Paroxetine has slightly higher response and remission rates for PTSD

3222:

A study examining publication of results from FDA-evaluated antidepressants concluded that those with favorable results were much more likely to be published than those with negative results. Furthermore, an investigation of 185 meta-analyses on antidepressants found that 79% of them had authors

2267:, an SSRI, has also shown efficacy in animal models of graft vs. host disease. SSRIs have also been used successfully as pain relievers in patients undergoing oncology treatment. The effectiveness of this has been hypothesized to be at least in part due to the anti-inflammatory effects of SSRIs. 1851:

SSRIs inhibit the reuptake of serotonin. As a result, the serotonin stays in the synaptic gap longer than it normally would, and may repeatedly stimulate the receptors of the recipient cell. In the short run, this leads to an increase in signaling across synapses in which serotonin serves as the

1227:

SSRI use in pregnancy has been associated with a variety of risks with varying degrees of proof of causation. As depression is independently associated with negative pregnancy outcomes, determining the extent to which observed associations between antidepressant use and specific adverse outcomes

557:

SSRIs are effective for the treatment of premature ejaculation. Taking SSRIs on a chronic, daily basis is more effective than taking them prior to sexual activity. The increased efficacy of treatment when taking SSRIs on a daily basis is consistent with clinical observations that the therapeutic

4039:

The commonly used method of estimating the 'response' to drug treatment in clinical trials of antidepressants (arbitrarily set at a 50% reduction in symptoms), involves the categorisation of continuous data from symptom scales, and therefore does not provide an independent arbiter of clinical

3229:

has argued that warning signs were available for many years prior to regulatory authorities moving to put warnings on antidepressant labels that they might cause suicidal thoughts. At the time these warnings were added, others argued that the evidence for harm remained unpersuasive and others

975:

is increased, but the absolute risk is very low. SSRIs are known to cause platelet dysfunction. This risk is greater in those who are also on anticoagulants, antiplatelet agents and NSAIDs (nonsteroidal anti-inflammatory drugs), as well as with the co-existence of underlying diseases such as

10952: 1801:

Serotonin reuptake inhibitors should not be abruptly discontinued after extended therapy, and whenever possible, should be tapered over several weeks to minimize discontinuation-related symptoms which may include nausea, headache, dizziness, chills, body aches, paresthesias, insomnia, and

357:

A 2012 meta-analysis of fluoxetine and venlafaxine concluded that statistically and clinically significant treatment effects were observed for each drug relative to placebo irrespective of baseline depression severity; some of the authors however disclosed substantial relationships with

5500:

Buspirone, a non-benzodiazepine anxiolytic, have even demonstrated enhancement of sexual function in certain individuals. For this reason, they have been proposed as augmentation agents (antidotes) or substitution agents in patients with emerging sexual dysfunction after treatment with

1182:

more than older antidepressants. The researchers stated that if SSRIs increase suicide risk in some patients, the number of additional deaths is very small because ecological studies have generally found that suicide mortality has declined (or at least not increased) as SSRI use has

1242:

The FDA issued a statement on July 19, 2006, stating nursing mothers on SSRIs must discuss treatment with their physicians. However, the medical literature on the safety of SSRIs has determined that some SSRIs like Sertraline and Paroxetine are considered safe for breastfeeding.

871:. Higher doses of antidepressants seem to be more likely to produce emotional blunting than lower doses. It can be decreased by reducing dosage, discontinuing the medication, or switching to a different antidepressant that may have less propensity for causing this side effect. 385:

review concluded that, for children and adolescents, SSRIs "may reduce depression symptoms in a small and unimportant way compared with placebo." However, it also noted significant methodological limitations that make drawing definitive conclusions about efficacy difficult.

984:

Evidence from longitudinal, cross-sectional, and prospective cohort studies suggests an association between SSRI usage at therapeutic doses and a decrease in bone mineral density, as well as increased fracture risk, a relationship that appears to persist even with adjuvant

2236:, programmed cell death, in T-cells. The full mechanism of action for the anti-inflammatory effects of SSRIs is not fully known. However, there is evidence for various pathways to have a hand in the mechanism. One such possible mechanism is the increased levels of 942:

genotype. The study’s authors suggest that genotyping should be performed on people with DMR to evaluate serotonin transporter (SERT) activity. They also urge practitioners to exercise caution when prescribing SSRIs to individuals with a familial history of DMR.

2227:

In addition to affecting cytokine production, there is evidence that treatment with SSRIs has effects on the proliferation and viability of immune system cells involved in both innate and adaptive immunity. Evidence shows that SSRIs can inhibit proliferation in

634:

function; (3) specific effects on peripheral tissues and organs, such as the penis, that mediate sexual function; and (4) direct or indirect effects on hormones mediating sexual function. Management strategies include: for erectile dysfunction the addition of a

1852:

primary neurotransmitter. On chronic dosing, the increased occupancy of post-synaptic serotonin receptors signals the pre-synaptic neuron to synthesize and release less serotonin. Serotonin levels within the synapse drop, then rise again, ultimately leading to

9607:

Viktorin A, Lichtenstein P, Thase ME, Larsson H, Lundholm C, Magnusson PK, Landén M (October 2014). "The risk of switch to mania in patients with bipolar disorder during treatment with an antidepressant alone and in combination with a mood stabilizer".

10618:

Shadfar S, Kim YG, Katila N, Neupane S, Ojha U, Bhurtel S, Srivastav S, Jeong GS, Park PH, Hong JT, Choi DY (January 2018). "Neuroprotective Effects of Antidepressants via Upregulation of Neurotrophic Factors in the MPTP Model of Parkinson's Disease".

3085:(SRIs). They are about at least 10-fold selective for inhibition of serotonin reuptake over norepinephrine reuptake. The selectivity ratios are approximately 1:30 for venlafaxine, 1:10 for duloxetine, and 1:14 for desvenlafaxine. At low doses, these 10916: 8753:

Maslej MM, Bolker BM, Russell MJ, Eaton K, Durisko Z, Hollon SD, Swanson GM, Thomson JA, Mulsant BH, Andrews PW (2017). "The Mortality and Myocardial Effects of Antidepressants Are Moderated by Preexisting Cardiovascular Disease: A Meta-Analysis".

859:. It may be experienced as either beneficial or detrimental depending on the situation. This side effect has been particularly associated with serotonergic antidepressants like SSRIs and SNRIs, but may be less with atypical antidepressants like 8646:

Rihmer Z, Akiskal H (August 2006). "Do antidepressants t(h)reat(en) depressives? Toward a clinically judicious formulation of the antidepressant-suicidality FDA advisory in light of declining national suicide statistics from many countries".

257:

SSRIs are the most widely prescribed antidepressants in many countries. The efficacy of SSRIs in mild or moderate cases of depression has been disputed and may or may not be outweighed by side effects, especially in adolescent populations.

1839:

on the surface of the recipient postsynaptic cell, which upon this stimulation, in turn, relays the signal. About 10% of the neurotransmitters are lost in this process; the other 90% are released from the receptors and taken up again by

6919: 1867:

Their effects on serotonin blood levels, which take weeks to take effect, appear to be largely responsible for their slow-to-appear psychiatric effects. SSRIs mediate their action largely with high occupancy in a total of all

8520:"Selective Serotonin Reuptake Inhibitors (SSRIs): Overview of regulatory status and CSM advice relating to major depressive disorder (MDD) in children and adolescents including a summary of available safety and efficacy data" 516:. SSRIs (fluoxetine in particular) are preferred over other anti-depressants due to their acceptability, tolerability, and superior reduction of symptoms in short-term trials. Long-term efficacy remains poorly characterized. 12015:

Christou A, Papadavid G, Dalias P, Fotopoulos V, Michael C, Bayona JM, Piña B, Fatta-Kassinos D (March 2019). "Ranking of crop plants according to their potential to uptake and accumulate contaminants of emerging concern".

4236:

Hedges DW, Brown BL, Shwalb DA, Godfrey K, Larcher AM (January 2007). "The efficacy of selective serotonin reuptake inhibitors in adult social anxiety disorder: a meta-analysis of double-blind, placebo-controlled trials".

4664:

Asnis GM, Hameedi FA, Goddard AW, Potkin SG, Black D, Jameel M, Desagani K, Woods SW (August 2001). "Fluvoxamine in the treatment of panic disorder: a multi-center, double-blind, placebo-controlled study in outpatients".

7305:"Risk of upper gastrointestinal tract bleeding associated with selective serotonin reuptake inhibitors and venlafaxine therapy: interaction with nonsteroidal anti-inflammatory drugs and effect of acid-suppressing agents" 10973:

Więdłocha M, Marcinowicz P, Krupa R, Janoska-Jaździk M, Janus M, Dębowska W, Mosiołek A, Waszkiewicz N, Szulc A (January 2018). "Effect of antidepressant treatment on peripheral inflammation markers – A meta-analysis".

8405:

Tauscher-Wisniewski S, Nilsson M, Caldwell C, Plewes J, Allen AJ (October 2007). "Meta-analysis of aggression and/or hostility-related events in children and adolescents treated with fluoxetine compared with placebo".

835:(FDA) for failing to act on a citizen petition submitted in 2018. The petition seeks to have the risk of serious sexual side effects persisting after discontinuation mentioned in the product labels of SSRIs and SNRIs. 4355:

Katzman MA, Bleau P, Blier P, Chokka P, Kjernisted K, Van Ameringen M, Antony MM, Bouchard S, Brunet A, Flament M, Grigoriadis S, Mendlowitz S, O'Connor K, Rabheru K, Richter PM, Robichaud M, Walker JR (2014-07-02).

2297:' because they affect only the reuptake pumps responsible for serotonin, as opposed to earlier antidepressants, which affect other monoamine neurotransmitters as well, and as a result, SSRIs have fewer side effects. 3928:

Cipriani A, Furukawa TA, Salanti G, Chaimani A, Atkinson LZ, Ogawa Y, Leucht S, Ruhe HG, Turner EH, Higgins JP, Egger M, Takeshima N, Hayasaka Y, Imai H, Shinohara K, Tajika A, Ioannidis JP, Geddes JR (April 2018).

542:

patients, including those with and without symptoms of depression. A 2021 meta-analysis of randomized controlled clinical trials found no evidence pointing to their routine use to promote recovery following stroke.

1864:. Owing to the lack of a widely accepted comprehensive theory of the biology of mood disorders, there is no widely accepted theory of how these changes lead to the mood-elevating and anti-anxiety effects of SSRIs. 6994:

Pacher P, Ungvari Z, Nanasi PP, Furst S, Kecskemeti V (Jun 1999). "Speculations on difference between tricyclic and selective serotonin reuptake inhibitor antidepressants on their cardiac effects. Is there any?".

5473:

Trinchieri M, Trinchieri M, Perletti G, Magri V, Stamatiou K, Cai T, Montanari E, Trinchieri A (August 2021). "Erectile and Ejaculatory Dysfunction Associated with Use of Psychotropic Drugs: A Systematic Review".

6327: 7132: 6625:

Fagiolini A, Florea I, Loft H, Christensen MC (March 2021). "Effectiveness of Vortioxetine on Emotional Blunting in Patients with Major Depressive Disorder with inadequate response to SSRI/SNRI treatment".

1474:

There are a number of potential pharmacokinetic interactions between the various individual SSRIs and other medications. Most of these arise from the fact that every SSRI has the ability to inhibit certain

758:. The duration of PSSD symptoms appears to vary among patients, with some cases resolving in months and others in years or decades; one analysis of patient reports submitted between 1992 and 2021 in the 570:

is usually considered to be a significantly distressing side effect which may lead to noncompliance in patients receiving SSRIs. However, for those with premature ejaculation, this very same side effect

7046: 8550:"Selective serotonin reuptake inhibitors (SSRIs) and suicide in adults: meta-analysis of drug company data from placebo controlled, randomised controlled trials submitted to the MHRA's safety review" 5608: 8519: 7654:

Fernandes BS, Hodge JM, Pasco JA, Berk M, Williams LJ (January 2016). "Effects of Depression and Serotonergic Antidepressants on Bone: Mechanisms and Implications for the Treatment of Depression".

1856:

of post-synaptic serotonin receptors. Other, indirect effects may include increased norepinephrine output, increased neuronal cyclic AMP levels, and increased levels of regulatory factors such as

14434: 6586:"Efficacy of agomelatine and escitalopram on depression, subjective sleep and emotional experiences in patients with major depressive disorder: a 24-wk randomized, controlled, double-blind trial" 7265:

Andrade C, Sandarsh S, Chethan KB, Nagesh KS (December 2010). "Serotonin reuptake inhibitor antidepressants and abnormal bleeding: a review for clinicians and a reconsideration of mechanisms".

3571:

Jakobsen JC, Katakam KK, Schou A, Hellmuth SG, Stallknecht SE, Leth-Møller K, Iversen M, Banke MB, Petersen IJ, Klingenberg SL, Krogh J, Ebert SE, Timm A, Lindschou J, Gluud C (February 2017).

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active metabolites. Concomitant use of paroxetine and tamoxifen in women with breast cancer is associated with a higher risk of death, as much as a 91 percent in women who used it the longest.

1178:

A 2006 meta-analysis of randomized controlled trials suggests that SSRIs increase suicide ideation compared with placebo. However, the observational studies suggest that SSRIs did not increase

8888:"Increasing the risk of spontaneous abortion and major malformations in newborns following use of serotonin reuptake inhibitors during pregnancy: A systematic review and updated meta-analysis" 7786:

Winterhalder L, Eser P, Widmer J, Villiger PM, Aeberli D (December 2012). "Changes in volumetric BMD of radius and tibia upon antidepressant drug administration in young depressive patients".

8041:"Association of Coprescription of Triptan Antimigraine Drugs and Selective Serotonin Reuptake Inhibitor or Selective Norepinephrine Reuptake Inhibitor Antidepressants With Serotonin Syndrome" 1136:

in children with depression, though it was also associated with a slight increase in the risk of self-harm and suicidal ideation. Only two SSRIs are licensed for use with children in the UK,

6281:"Frequency of self-reported persistent post-treatment genital hypoesthesia among past antidepressant users: a cross-sectional survey of sexual and gender minority youth in Canada and the US" 11748:

Ebrahim S, Bance S, Athale A, Malachowski C, Ioannidis JP (February 2016). "Meta-analyses with industry involvement are massively published and report no caveats for antidepressants".

7067:

Castillero E, Fitzpatrick E, Keeney SJ, D'Angelo AM, Pressly BB, Simpson MT, Kurade M, Erwin WC, Moreno V, Camillo C, Shukla HJ, Inamdar VV, Aghali A, Grau JB, Salvati E (2023-01-04).

2211:, which leads to a decrease in inflammation levels and subsequently a decrease in the activation level of the immune response. These inflammatory cytokines have been shown to activate 10915:

Köhler CA, Freitas TH, Stubbs B, Maes M, Solmi M, Veronese N, de Andrade NQ, Morris G, Fernandes BS, Brunoni AR, Herrmann N, Raison CL, Miller BJ, Lanctôt KL, Carvalho AF (May 2018).

9937:

Jeppesen U, Gram LF, Vistisen K, Loft S, Poulsen HE, Brøsen K (1996). "Dose-dependent inhibition of CYP1A2, CYP2C19 and CYP2D6 by citalopram, fluoxetine, fluvoxamine and paroxetine".

1235:. According to some researches, decreased body weight of the child, intrauterine growth retardation, neonatal adaptive syndrome, and persistent pulmonary hypertension also was noted. 1096:

Meta analyses of short duration randomized clinical trials have found that SSRI use is related to a higher risk of suicidal behavior in children and adolescents. For instance, a 2004

1452:

Painkillers of the NSAIDs drug family may interfere and reduce efficiency of SSRIs and may compound the increased risk of gastrointestinal bleeds caused by SSRI use. NSAIDs include:

11339: 5995:

Chinchilla Alfaro K, van Hunsel F, Ekhart C (April 2022). "Persistent sexual dysfunction after SSRI withdrawal: a scoping review and presentation of 86 cases from the Netherlands".

11107:

Nazimek K, Strobel S, Bryniarski P, Kozlowski M, Filipczak-Bryniarska I, Bryniarski K (June 2017). "The role of macrophages in anti-inflammatory activity of antidepressant drugs".

11628:

Moltzen EK, Bang-Andersen B (2006). "Serotonin reuptake inhibitors: the corner stone in treatment of depression for half a century – a medicinal chemistry survey".

3931:"Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis" 1279:

and are not able to get enough oxygen into their bloodstream. About 1 to 2 babies per 1000 babies born in the U.S. develop PPHN shortly after birth, and often they need intensive

2285:

to predict whether patients will respond to SSRIs or have side effects that will cause their discontinuation, although these tests are not yet ready for widespread clinical use.

11520:

Mandrioli R, Protti M, Mercolini L (2018). "New-Generation, non-SSRI Antidepressants: Therapeutic Drug Monitoring and Pharmacological Interactions. Part 1: SNRIs, SMSs, SARIs".

9377:'t Jong GW, Einarson T, Koren G, Einarson A (November 2012). "Antidepressant use in pregnancy and persistent pulmonary hypertension of the newborn (PPHN): a systematic review". 9233:

Fenger-Grøn J, Thomsen M, Andersen KS, Nielsen RG (September 2011). "Paediatric outcomes following intrauterine exposure to serotonin reuptake inhibitors: a systematic review".

2219:

are a subset of immune cells responsible for host defense in the innate immune system. Macrophages can release cytokines and other chemicals to cause an inflammatory response.

7471:

de Abajo FJ (May 2011). "Effects of selective serotonin reuptake inhibitors on platelet function: mechanisms, clinical outcomes and implications for use in elderly patients".

1160:

A 2005 meta-analysis of drug company data found no evidence that SSRIs increased the risk of suicide; however, important protective or hazardous effects could not be excluded.

6150:

Peleg LC, Rabinovitch D, Lavie Y, et al. (January 2022). "Post-SSRI Sexual Dysfunction (PSSD): Biological Plausibility, Symptoms, Diagnosis, and Presumed Risk Factors".

469:

Antidepressants provide a modest-to-moderate reduction in anxiety in GAD, and are superior to placebo in treating GAD. The efficacy of different antidepressants is similar.

6940:

Citalopram and escitalopram: QT interval prolongation – new maximum daily dose restrictions (including in elderly patients), contraindications, and warnings

3283: 11186:

Saha M, Rizzo SA, Ramanathan M, Hightower RM, Santostefano KE, Terada N, Finkel RS, Berg JS, Chahin N, Pacak CA, Wagner RE, Alexander MS, Draper I, Kang PB (July 2019).

3573:"Selective serotonin reuptake inhibitors versus placebo in patients with major depressive disorder. A systematic review with meta-analysis and Trial Sequential Analysis" 10457: 9507:

Malm H, Brown AS, Gissler M, Gyllenberg D, Hinkka-Yli-Salomäki S, McKeague IW, Weissman M, Wickramaratne P, Artama M, Gingrich JA, Sourander A, et al. (May 2016).

377:(≥50% reduction in observer-rated symptoms). Odds ratios of response rates have been criticized for artificially inflating the apparent size of antidepressant benefits. 16297: 1228:

reflects a causative relationship has been difficult in some cases. In other cases, the attribution of adverse outcomes to antidepressant exposure seems fairly clear.

8250: 17323: 16983: 16292: 6314: 4568: 2220: 770:, two other poorly-understood conditions which have been suggested to share a common etiology with PSSD despite being associated with different types of medication. 11703:

Turner EH, Matthews AM, Linardatos E, Tell RA, Rosenthal R (January 2008). "Selective publication of antidepressant trials and its influence on apparent efficacy".

7124: 951:

SSRIs directly increase the risk of abnormal bleeding by lowering platelet serotonin levels, which are essential to platelet-driven hemostasis. SSRIs interact with

373:(ORs) ranging between 2.13 (95% credible interval 1.89–2.41) for amitriptyline and 1.37 (1.16–1.63) for reboxetine." The odds ratios were specifically in terms of 10483:"Selective serotonin reuptake inhibitor antidepressant treatment discontinuation syndrome: a review of the clinical evidence and the possible mechanisms involved" 4107:

Hetrick SE, McKenzie JE, Bailey AP, Sharma V, Moller CI, Badcock PB, Cox GR, Merry SN, Meader N, et al. (Cochrane Common Mental Disorders Group) (May 2021).

3411: 773:

Diagnostic criteria for PSSD were proposed in 2022, but as of 2023, there is no agreement on standards for diagnosis. It is considered a distinct phenomenon from

17747: 14126: 12374: 10917:"Peripheral Alterations in Cytokine and Chemokine Levels After Antidepressant Drug Treatment for Major Depressive Disorder: Systematic Review and Meta-Analysis" 3837:"Benefits from antidepressants: synthesis of 6-week patient-level outcomes from double-blind placebo-controlled randomized trials of fluoxetine and venlafaxine" 16352: 14469: 10872:

Köhler S, Cierpinsky K, Kronenberg G, Adli M (January 2016). "The serotonergic system in the neurobiology of depression: Relevance for novel antidepressants".

8495: 6078: 4863:

Legg LA, Rudberg AS, Hua X, Wu S, Hackett ML, Tilney R, Lindgren L, Kutlubaev MA, Hsieh CF, Barugh AJ, Hankey GJ, Lundström E, Dennis M, Mead GE (2021-11-15).

3268: 7038: 318:(NICE) as a first-line treatment of severe depression and for the treatment of mild-to-moderate depression that persists after conservative measures such as 100: 5641:

Kanaly KA, Berman JR (December 2002). "Sexual side effects of SSRI medications: potential treatment strategies for SSRI-induced female sexual dysfunction".

1768:

of the SSRIs, most patients will have mild or no symptoms following moderate overdoses. The most commonly reported severe effect following SSRI overdose is

8441:

Gibbons RD, Hur K, Bhaumik DK, Mann JJ (November 2006). "The relationship between antidepressant prescription rates and rate of early adolescent suicide".

3341: 11880:

Khan A, Khan S, Kolts R, Brown WA (April 2003). "Suicide rates in clinical trials of SSRIs, other antidepressants, and placebo: analysis of FDA reports".

8527: 16494: 8523: 8491: 6950: 1125: 9420:

Gentile S (August 2015). "Prenatal antidepressant exposure and the risk of autism spectrum disorders in children. Are we looking at the fall of Gods?".

6193:

Giatti S, Diviccaro S, Panzica G, Melcangi RC (August 2018). "Post-finasteride syndrome and post-SSRI sexual dysfunction: two sides of the same coin?".

938:

was identified, indicating that SSRIs could hasten the progression of degenerative mitral valve regurgitation (DMR), especially in individuals carrying

9037:

Einarson TR, Kennedy D, Einarson A (2012). "Do findings differ across research design? The case of antidepressant use in pregnancy and malformations".

8840:

Rahimi R, Nikfar S, Abdollahi M (2006). "Pregnancy outcomes following exposure to serotonin reuptake inhibitors: a meta-analysis of clinical trials".

7899: 7697:

Nyandege AN, Slattum PW, Harpe SE (April 2015). "Risk of fracture and the concomitant use of bisphosphonates with osteoporosis-inducing medications".

812:

should be amended to include information regarding a possible risk of persistent sexual dysfunction. Following the EMA assessment, a safety review by

11968:"Suicidal thoughts and behavior with antidepressant treatment: reanalysis of the randomized placebo-controlled studies of fluoxetine and venlafaxine" 10015: 8177: 8141: 3444: 2304:, which were the most commonly used class of antidepressants before the development of SSRIs. However, SSRIs have the important advantage that their 1194:

Black Box suicide warning inclusion in the prescription. The authors discussed the suicide rates might increase also as a consequence of the warning.

315: 11284:

Anderson IM (April 2000). "Selective serotonin reuptake inhibitors versus tricyclic antidepressants: a meta-analysis of efficacy and tolerability".

5760:

Scherzer ND, Reddy AG, Le TV, Chernobylsky D, Hellstrom WJ (April 2019). "Unintended Consequences: A Review of Pharmacologically-Induced Priapism".

4599: 17737: 12260: 8302: 8274: 4790: 1175:

more help for depression. Recent clinical data on large samples in the US too have revealed a protective effect of antidepressant against suicide.

13962: 12341: 11666:

Haddad PM (1999). "Selective Serotonin Reuptake Inhibitors (SSRIs) Past, Present and Future. Edited by S. Clare Standford, R.G. Landes Company".

6942: 4013:

Moncrieff J, Kirsch I (July 2015). "Empirically derived criteria cast doubt on the clinical significance of antidepressant-placebo differences".

3659: 3278: 1002: 801: 630:(pleasureless orgasm). Sexual problems are common with SSRIs. Poor sexual function is one of the most common reasons people stop the medication. 347: 4795: 4793: 17582: 1187:

suicidal behavior for adults between the ages of 25 and 64. For adults older than 64, SSRI's seem to reduce the risk of both suicidal behavior.

4054:"Methodological Flaws, Conflicts of Interest, and Scientific Fallacies: Implications for the Evaluation of Antidepressants' Efficacy and Harm" 2244:(PKA), a cAMP dependent protein. Other possible pathways include interference with calcium ion channels, or inducing cell death pathways like 17136: 17091: 16703: 5721:"Deleterious effects of selective serotonin reuptake inhibitor treatment on semen parameters in patients with lifelong premature ejaculation" 3886:"Multiple possible inaccuracies cast doubt on a recent report suggesting selective serotonin reuptake inhibitors to be toxic and ineffective" 1005:

antidepressants may cause jaw pain/jaw spasm reversible syndrome (although it is not common). Buspirone appears to be successful in treating

9165: 17687: 17602: 17028: 16414: 15956: 15951: 15232: 15227: 15046: 14025: 13633: 13618: 13548: 13156: 12407: 5372:

Gitlin MJ (September 1994). "Psychotropic medications and their effects on sexual function: diagnosis, biology, and treatment approaches".

1772:; serotonin toxicity is usually associated with very high overdoses or multiple drug ingestion. Other reported significant effects include 1425: 1097: 990:

to fall risk in elderly patients using the medication. The loss of bone density does not appear to occur in younger patients taking SSRIs.

406:

disorder, although their effects on symptoms is not always robust and their use is sometimes rejected in favor of psychological therapies.

11327: 8105: 4407: 1259:

exposure. These syndromes are short-lived, but insufficient long-term data is available to determine whether there are long-term effects.

17692: 17617: 17567: 17238: 16973: 16951: 16926: 16916: 16761: 14119: 11575: 11447: 10675:

Hindmarch I, Hashimoto K (April 2010). "Cognition and depression: the effects of fluvoxamine, a sigma-1 receptor agonist, reconsidered".

5871:"Selective serotonin reuptake inhibitors, post-treatment sexual dysfunction and persistent genital arousal disorder: A systematic review" 4324: 2151:

receptor in the actions of the other SSRIs is uncertain and questionable due to their very low affinity for the receptor relative to the

1255:, a syndrome of neurological, gastrointestinal, autonomic, endocrine and/or respiratory symptoms among a large minority of infants with 17313: 17263: 17205: 17200: 15735: 9782:"Antidepressant effects of selective serotonin reuptake inhibitors (SSRIs) are attenuated by antiinflammatory drugs in mice and humans" 6970: 6826:

Huybrechts KF, Palmsten K, Avorn J, Cohen LS, Holmes LB, Franklin JM, Mogun H, Levin R, Kowal M, Setoguchi S, Hernández-Díaz S (2014).

4773: 11923:

Kaizar EE, Greenhouse JB, Seltman H, Kelleher K (2006). "Do antidepressants cause suicidality in children? A Bayesian meta-analysis".

9509:"Gestational Exposure to Selective Serotonin Reuptake Inhibitors and Offspring Psychiatric Disorders: A National Register-Based Study" 5943:

JN, Patacchini A, Pearlman AM, Pukall CF, Raj S, Reisman Y, Rubin RS, Schreiber R, Shipko S, Vašečková B, Waraich A (1 January 2022).

2251:

The anti-inflammatory effects of SSRIs have prompted studies of the efficacy of SSRIs in the treatment of autoimmune diseases such as

2224:

shown to upregulate anti-inflammatory cytokines such as IL-10. Taken together, this reduces the overall inflammatory immune response.

1835:

that sends the information releases neurotransmitters including serotonin into that gap. The neurotransmitters are then recognized by

17527: 17522: 17517: 17512: 17293: 17106: 16876: 16332: 16073: 14464: 14459: 12158: 10237:

Isbister GK, Bowe SJ, Dawson A, Whyte IM (2004). "Relative toxicity of selective serotonin reuptake inhibitors (SSRIs) in overdose".

8939:"Selective serotonin reuptake inhibitor (SSRI) use during pregnancy and risk of preterm birth: a systematic review and meta-analysis" 8599:"Association between suicide attempts and selective serotonin reuptake inhibitors: systematic review of randomised controlled trials" 1761:

reported following massive single ingestions, although this is exceedingly uncommon when compared to the tricyclic antidepressants.

369:

to be one of the most effective. They showed that "In terms of efficacy, all antidepressants were more effective than placebo, with

17542: 17537: 17532: 17423: 17418: 17298: 17003: 16901: 16896: 16881: 16816: 16811: 16558: 16457: 10185:"Selective serotonin reuptake inhibitors and breast cancer mortality in women receiving tamoxifen: a population based cohort study" 9328:

Grigoriadis S, Vonderporten EH, Mamisashvili L, Tomlinson G, Dennis CL, Koren G, Steiner M, Mousmanis P, Cheung A, Ross LE (2014).

4282:"Pharmacotherapy for Post-traumatic Stress Disorder In Combat Veterans: Focus on Antidepressants and Atypical Antipsychotic Agents" 303: 5916: 4408:"Obsessive-compulsive disorder: Core interventions in the treatment of obsessive-compulsive disorder and body dysmorphic disorder" 1231:

SSRI use in pregnancy is associated with an increased risk of spontaneous abortion of about 1.7-fold. Use is also associated with

365:

In 2018, a systematic review and network meta-analysis comparing the efficacy and acceptability of 21 antidepressant drugs showed

17507: 16998: 16487: 13990: 13603: 12202: 9140: 7387:

Serebruany VL (February 2006). "Selective serotonin reuptake inhibitors and increased bleeding risk: are we missing something?".

7191:

Weinrieb RM, Auriacombe M, Lynch KG, Lewis JD (March 2005). "Selective serotonin re-uptake inhibitors and the risk of bleeding".

3188: 774: 13971: 9330:"Prenatal exposure to antidepressants and persistent pulmonary hypertension of the newborn: systematic review and meta-analysis" 6131:

There is still no definitive treatment for PSSD. Low-power laser irradiation and phototherapy have shown some promising results.

17492: 17487: 14454: 14112: 8328:"Psychological therapies versus antidepressant medication, alone and in combination for depression in children and adolescents" 7039:"Deciphering the Connection of Serotonin to Degenerative Mitral Valve Regurgitation - Advances in Cardiology and Heart Surgery" 3196:

was introduced in 1982 and was the first SSRI to be sold. Despite its efficacy, statistically significant increase in cases of

7069:"Decreased serotonin transporter activity in the mitral valve contributes to progression of degenerative mitral regurgitation" 4358:"Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsessive-compulsive disorders" 13906: 13269: 13213: 11679: 11609: 11569: 11441: 11414: 10748: 10541: 10451: 10438: 10418: 9881: 9840: 8099: 7246: 4800: 4438:

Arroll B, Elley CR, Fishman T, Goodyear-Smith FA, Kenealy T, Blashki G, Kerse N, Macgillivray S (July 2009). Arroll B (ed.).

3394: 3317: 10280:

Borys DJ, Setzer SC, Ling LJ, Reisdorf JJ, Day LC, Krenzelok EP (1992). "Acute fluoxetine overdose: a report of 234 cases".

8682:

Hall WD, Lucke J (2006). "How have the selective serotonin reuptake inhibitor antidepressants affected suicide mortality?".

2176:, and an increased risk of depression. Data also shows that using pro-inflammatory agents in the treatment of diseases like 10731:

Albayrak Y, Hashimoto K (2017). "Sigma-1 Receptor Agonists and Their Clinical Implications in Neuropsychiatric Disorders".

8243: 6438:"Emotional Blunting, Cognitive Impairment, Bone Fractures, and Bleeding as Possible Side Effects of Long-Term Use of SSRIs" 5451: 4095:

against the use of dichotomization (28–30) because it produces, among others, systematically inflated effect sizes (31–33).

3123: 523:. SSRIs provide short-term reductions in binge eating behavior, but have not been associated with significant weight loss. 11017:

Vogelzangs N, Duivis HE, Beekman AT, Kluft C, Neuteboom J, Hoogendijk W, Smit JH, de Jonge P, Penninx BW (February 2012).

5267: 325:

There has been controversy regarding the efficacy of SSRIs in treating depression depending on its severity and duration.

16441: 13955: 12440: 4708:

Bighelli I, Castellazzi M, Cipriani A, Girlanda F, Guaiana G, Koesters M, Turrini G, Furukawa TA, Barbui C (April 2018).

790: 734:

or loss of pleasurable sensation associated with orgasm, and a reduction or loss of sensitivity in the genitals or other

10571:"P-glycoprotein inhibition increases the brain distribution and antidepressant-like activity of escitalopram in rodents" 7344:

Hackam DG, Mrkobrada M (October 2012). "Selective serotonin reuptake inhibitors and brain hemorrhage: a meta-analysis".

6039: 5945:"Diagnostic criteria for enduring sexual dysfunction after treatment with antidepressants, finasteride and isotretinoin" 4561: 4488: 2188:

in depressed patients. This link has led scientists to investigate the effects of antidepressants on the immune system.

16480: 14807: 12308: 6040:"A clinical review of antidepressants, their sexual side-effects, post-SSRI sexual dysfunction, and serotonin syndrome" 5564:

Serretti A, Chiesa A (June 2009). "Treatment-emergent sexual dysfunction related to antidepressants: a meta-analysis".

5246:"Persistence of Sexual Dysfunction Side Effects after Discontinuation of Antidepressant Medications: Emerging Evidence" 3223:

affiliated in some way to pharmaceutical companies and that they were reluctant to report caveats for antidepressants.

3741:

Horder J, Matthews P, Waldmann R (June 2010). "Placebo, Prozac and PLoS: significant lessons for psychopharmacology".

707:

Post-SSRI sexual dysfunction (PSSD) refers to a set of symptoms reported by some people who have taken SSRIs or other

11687: 11069:

Kalkman HO, Feuerbach D (July 2016). "Antidepressant therapies inhibit inflammation and microglial M1-polarization".

3692:"Initial Severity and Antidepressant Benefits: A Meta-Analysis of Data Submitted to the Food and Drug Administration" 2324: 1738:

may decrease the plasma concentration of active metabolite morphine, which may result in reduced analgesic efficacy.

1271:(PPHN) is a serious and life-threatening, but very rare, lung condition that occurs soon after birth of the newborn. 1145: 563: 512:

Antidepressants are recommended as an alternative or additional first step to self-help programs in the treatment of

478: 287: 8484: 4164: 504:, another SSRI, has shown positive results. However, evidence for their effectiveness and acceptability is unclear. 17752: 16256: 13923: 13230: 8383: 2976: 2766: 1179: 10774:"The opposite effects of fluvoxamine and sertraline in the treatment of psychotic major depression: a case report" 6486:"Emotional Blunting in Patients With Major Depressive Disorder: A Brief Non-systematic Review of Current Research" 496:

CR was superior to placebo on the primary outcome measure. In a 10-week randomized controlled, double-blind trial

17742: 16583: 12131: 11019:"Association of depressive disorders, depression characteristics and antidepressant medication with inflammation" 9105:

Koren G, Nordeng HM (February 2013). "Selective serotonin reuptake inhibitors and malformations: case closed?".

8485:"Report of the CSM expert working group on the safety of selective serotonin reuptake inhibitor antidepressants" 8244:"Review and evaluation of clinical data. Relationship between psychiatric drugs and pediatric suicidal behavior" 3364: 410:

was the first drug to be approved for social anxiety disorder and it is considered effective for this disorder;

16623: 16461: 13948: 13343: 7592: 3006: 2320: 2237: 778: 439: 3547: 3197: 2316:. Tricyclic antidepressants also have a higher risk of serious cardiovascular side effects, which SSRIs lack. 1726:) have interaction potential with selective serotonin reuptake inhibitors. The concomitant use of some SSRIs ( 572: 15517: 12151: 11237:"Genetic screening for SSRI drug response among those with major depression: great promise and unseen perils" 1796: 450: 299: 7516:"Use of selective serotonin reuptake inhibitors and risk of fracture: a systematic review and meta-analysis" 4955:

Machado-Vieira R, Baumann J, Wheeler-Castillo C, Latov D, Henter ID, Salvadore G, Zarate CA (January 2010).

2196:, a cytokine that has proinflammatory effects, in patients taking SSRIs compared to non-medicated patients. 17717: 16437: 14154: 14135: 13678: 10011: 9190:

Gentile S, Rossi A, Bellantuono C (2007). "SSRIs during breastfeeding: spotlight on milk-to-plasma ratio".

8797:

Malm H (December 2012). "Prenatal exposure to selective serotonin reuptake inhibitors and infant outcome".

8297: 7743:

Warden SJ, Fuchs RK (October 2016). "Do Selective Serotonin Reuptake Inhibitors (SSRIs) Cause Fractures?".

6411: 3436: 3082: 2736: 2136: 1348: 1323:. When taken with mood stabilizers, the risk of switching is not increased, however when taking SSRIs as a 1252: 908: 832: 708: 463: 462:

SSRIs are recommended by the National Institute for Health and Care Excellence (NICE) for the treatment of

331: 279: 149: 11360:

Montgomery SA (July 2008). "Tolerability of serotonin norepinephrine reuptake inhibitor antidepressants".

10559:

Kolb, Bryan and Wishaw Ian. An Introduction to Brain and Behavior. New York: Worth Publishers 2006, Print.

8166: 8130: 5620: 3167:(YM-992, YM-35995) are similar drugs that were never marketed. They are SRIs and litoxetine is also a 5-HT 2263:. These studies have been performed in animal models but have shown consistent immune regulatory effects. 442:

in individual published trials of the drugs for social anxiety disorder have ranged from –0.029 to 1.214.

390:

is the only SSRI authorized for use in children and adolescents with moderate to severe depression in the

322:. They recommend against their routine use by those who have chronic health problems and mild depression. 17408: 15801: 15077: 13663: 12813: 12746: 8203:"Antidepressant drug therapy and suicide in severely depressed children and adults: A case-control study" 4592: 3046: 3036: 3016: 2986: 2756: 2256: 1787:

Poisoning is also known in animals, and some toxicity information is available for veterinary treatment.

1212: 1064: 719: 8292: 8278: 7920:

Albayrak Y, Ekinci O (2011). "Duloxetine-induced nocturnal bruxism resolved by buspirone: case report".

762:

listed a case which had reportedly persisted for 23 years. The symptoms of PSSD are largely shared with

14796: 14308: 12576: 12484: 11783: 9902:

Wyska E (October 2019). "Pharmacokinetic considerations for current state-of-the-art antidepressants".

5329:

Kennedy SH, Rizvi S (April 2009). "Sexual dysfunction, depression, and the impact of antidepressants".

3251: 3226: 3026: 2996: 2881: 2818: 2776: 2746: 2726: 2180:

can lead to depression. Several meta-analytical studies have found increased levels of proinflammatory

2075:

In addition to their actions as reuptake inhibitors of serotonin, some SSRIs are also, coincidentally,

935: 852: 247: 7557:"Osteoporosis in patients taking selective serotonin reuptake inhibitors: a focus on fracture outcome" 6939: 5131:

Lane RM (1998). "SSRI-induced extrapyramidal side-effects and akathisia: implications for treatment".

4957:"The Timing of Antidepressant Effects: A Comparison of Diverse Pharmacological and Somatic Treatments" 3670: 3469:

Fournier JC, DeRubeis RJ, Hollon SD, Dimidjian S, Amsterdam JD, Shelton RC, Fawcett J (January 2010).

2204: 17353: 17061: 14040: 13648: 13262: 12588: 10358:

Sporer KA (August 1995). "The serotonin syndrome. Implicated drugs, pathophysiology and management".

9169: 7863: 7153:

Andrade C, Sharma E (September 2016). "Serotonin Reuptake Inhibitors and Risk of Abnormal Bleeding".

6323: 6105:

Bala A, Nguyen HM, Hellstrom WJ (January 2018). "Post-SSRI Sexual Dysfunction: A Literature Review".

3273: 3239: 3213: 2871: 2232:, which are important cells for adaptive immunity and can induce inflammation. SSRIs can also induce 1419: 1296: 1171:. No difference risk of suicide attempts was detected between SSRIs versus tricyclic antidepressants. 1168: 1105: 805: 786: 782: 692: 267: 205: 89: 11800: 11470:"The Role of Levomilnacipran in the Management of Major Depressive Disorder: A Comprehensive Review" 4109:"New generation antidepressants for depression in children and adolescents: a network meta-analysis" 3089:

act mostly as SSRIs; only at higher doses do they also prominently inhibit norepinephrine reuptake.

12144: 11717: 6875:

Goldberg RJ (1998). "Selective serotonin reuptake inhibitors: infrequent medical adverse effects".

6279:

Pirani Y, Delgado-Ron JA, Marinho P, Gupta A, Grey E, Watt S, MacKinnon KR, Salway T (2024-09-20).

2301: 847:, characterized by reduced intensity of both positive and negative emotions as well as symptoms of 162: 16274: 13911: 13218: 10183:

Kelly CM, Juurlink DN, Gomes T, Duong-Hua M, Pritchard KI, Austin PC, Paszat LF (February 2010).

8719:"Ten years after the FDA black box warning for antidepressant drugs: A critical narrative review" 5209:

Leo RJ (1996). "Movement disorders associated with the serotonin selective reuptake inhibitors".

3263: 1836: 1303:, but did find an association with increased rates of depression diagnoses in early adolescence. 1163:

A 2005 review observed that suicide attempts are increased in those who use SSRIs as compared to

403: 382: 275: 5513:

Montejo AL, Prieto N, de Alarcón R, Casado-Espada N, de la Iglesia J, Montejo L (October 2019).

5059:"Is Sertraline a Good Pharmacological Strategy to Control Anger? Results of a Systematic Review" 526:

Clinical trials have generated mostly negative results for the use of SSRIs in the treatment of

17562: 17363: 17071: 16613: 16453: 16449: 15856: 15132: 14562: 14515: 14076: 13053: 12524: 11795: 11712: 8089: 6779:"Antidepressant Use and Risk of Coronary Heart Disease: Meta-Analysis of Observational Studies" 6280: 2390: 2366: 2294: 1268: 1216: 892: 856: 739: 11559: 11431: 11404: 9865: 8376:"Overview | Depression in adults: recognition and management | Guidance | NICE" 6436:

Marazziti D, Mucci F, Tripodi B, Carbone MG, Muscarella A, Falaschi V, Baroni S (April 2019).

4414: 4331: 3382: 1031:

is a condition that can range from mild (most common) to deadly. Mild symptoms may consist of

699:, cases of priapism have also been reported with certain SSRIs (e.g. fluoxetine, citalopram). 16968: 15574: 15506: 14980: 14282: 14066: 12494: 11599: 5609:"Antidepressant-Associated Sexual Dysfunction: A Potentially Avoidable Therapeutic Challenge" 3217: 3104:

that inhibit serotonin and norepinephrine to similar degrees, both with ratios close to 1:1.

2411: 2380: 2313: 2152: 2076: 1890: 1841: 1215:(+14%) in the general population. Conversely, risks were not greater in people with existing 1133: 1072: 972: 931:

monitoring in patients with severe pre-existing cardiovascular disease who are taking SSRIs.

916: 552: 520: 243: 239: 135: 117: 33: 17: 9857: 8131:"Clinical review: relationship between antidepressant drugs and suicidal behavior in adults" 6963: 4762: 16791: 16445: 16317: 15846: 15390: 15122: 14552: 14531: 14143: 13575: 13255: 13173: 13088: 12029: 10437:

Gelenberg AJ, Freeman MP, Markowitz JC, Rosenbaum JF, Thase ME, Trivedi MH (October 2010).

9386: 8849: 8597:

Fergusson D, Doucette S, Glass KC, Shapiro S, Healy D, Hebert P, Hutton B (February 2005).

8326:

Cox GR, Callahan P, Churchill R, Hunot V, Merry SN, Parker AG, Hetrick SE (November 2014).

5174:

Koliscak LP, Makela EH (2009). "Selective serotonin reuptake inhibitor-induced akathisia".

2649: 2169: 1373: 1032: 883:

is the most common and important ocular side effect of SSRIs, and often goes misdiagnosed.

723: 654:

is sometimes used off-label to reduce sexual dysfunction associated with the use of SSRIs.

619: 251: 9144: 6681:"Selective serotonin reuptake inhibitors: a review of its effects on intraocular pressure" 5515:"Management Strategies for Antidepressant-Related Sexual Dysfunction: A Clinical Approach" 8: 16131: 15976: 15841: 15569: 15426: 15252: 15117: 14772: 14547: 12999: 12939: 9311: 3156: 2104: 1291:

According to a 2015 review available data found that "some signal exists suggesting that

727: 12033: 11983: 9390: 8853: 4464: 4439: 3852: 3690:

Kirsch I, Deacon BJ, Huedo-Medina TB, Scoboria A, Moore TJ, Johnson BT (February 2008).

1207:

found that antidepressants including SSRIs were associated with significantly increased

17626: 16653: 16627: 16506: 16216: 14242: 12190: 12186: 12063: 11992: 11967: 11948: 11905: 11821: 11494: 11469: 11385: 11266: 11212: 11187: 11043: 11018: 10999: 10944: 10897: 10849: 10824: 10800: 10773: 10700: 10644: 10595: 10570: 10509: 10482: 10383: 10340: 10262: 10209: 10184: 10160: 10135: 10111: 10086: 10062: 10037: 9962: 9808: 9781: 9762: 9643: 9584: 9557: 9533: 9508: 9486: 9354: 9329: 9288: 9261: 9215: 9014: 8989: 8965: 8938: 8914: 8887: 8881: 8879: 8822: 8779: 8466: 8352: 8327: 8174:

Overview for December 13 Meeting of Psychopharmacologic Drugs Advisory Committee (PDAC)

8138:

Overview for December 13 Meeting of Psychopharmacologic Drugs Advisory Committee (PDAC)

8065: 8040: 8021: 7973: 7956: 7891: 7839: 7814: 7768: 7722: 7679: 7584: 7496: 7448: 7439: 7423: 7369: 7216: 7101: 7068: 7020: 6852: 6827: 6803: 6778: 6754: 6729: 6705: 6680: 6661: 6561: 6536: 6512: 6485: 6454: 6437: 6369: 6261: 6218: 6175: 6070: 6020: 5969: 5944: 5908: 5870: 5829: 5804: 5785: 5696: 5669: 5589: 5541: 5514: 5354: 5156: 5085: 5058: 5034: 5007: 4983: 4956: 4897: 4864: 4734: 4709: 4690: 4384: 4357: 4298: 4281: 4262: 4213: 4186: 4133: 4108: 4080: 4053: 3955: 3930: 3861: 3836: 3776: 3718: 3691: 3599: 3572: 3495: 3470: 3356: 3119: 3115: 2252: 1769: 1751: 1409: 1336: 1028: 1018: 844: 611: 559: 227: 11857: 11840: 11533: 11485: 11297: 10840: 10328: 9082: 9065: 8623: 8598: 8574: 8549: 7008: 5820: 4678: 3946: 16207: 14945: 14652: 14227: 13417: 13190: 13092: 12611: 12110: 12102: 12055: 11997: 11940: 11897: 11862: 11813: 11765: 11730: 11683: 11645: 11605: 11565: 11537: 11499: 11437: 11410: 11377: 11301: 11258: 11217: 11168: 11124: 11086: 11082: 11048: 10991: 10936: 10889: 10854: 10805: 10754: 10744: 10692: 10636: 10600: 10537: 10514: 10447: 10414: 10375: 10371: 10332: 10315:

Oström M, Eriksson A, Thorson J, Spigset O (1996). "Fatal overdose with citalopram".

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Kirsch I, Moncrieff J (July 2007). "Clinical trials and the response rate illusion".

3960: 3907: 3866: 3817: 3796:"Efficacy of antidepressants: a re-analysis and re-interpretation of the Kirsch data" 3768: 3723: 3604: 3539: 3500: 3390: 3323: 3313: 1765: 1109: 1068: 960: 928: 920: 912: 896: 755: 747: 567: 319: 112: 12067: 11952: 11909: 11389: 11270: 11003: 10901: 10704: 10387: 10266: 9966: 9766: 9647: 9457:"Use of selective serotonin reuptake inhibitors during pregnancy and risk of autism" 8876: 8826: 8025: 7726: 7588: 7373: 7220: 7125:"Serotonin can potentially accelerate degenerative mitral regurgitation, study says" 7024: 5789: 5160: 4694: 4266: 3780: 3471:"Antidepressant drug effects and depression severity: a patient-level meta-analysis" 2199:

Treatment with SSRIs has shown reduced production of inflammatory cytokines such as

2135:

receptor by clinical dosages of fluvoxamine has been observed in the human brain in

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O'Brien FE, O'Connor RM, Clarke G, Dinan TG, Griffin BT, Cryan JF (October 2013).

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Taylor MJ, Rudkin L, Bullemor-Day P, Lubin J, Chukwujekwu C, Hawton K (May 2013).

2308:

is high, and, therefore, they are much more difficult to use as a means to commit

1132:

judged fluoxetine (Prozac) to be the only antidepressant that offered a favorable

767: 17452: 17233: 17141: 16741: 16731: 16282: 16157: 16099: 16087: 15755: 15394: 15026: 14960: 14374: 14262: 14237: 13781: 13773: 13763: 13560: 13291: 13102: 13096: 12909: 12283: 12041: 11163: 11146: 10740: 10102: 8810: 8454: 8056: 7933: 7830: 7400: 7357: 7084: 6946: 6058: 5577: 5342: 5290:"Strategies for managing sexual dysfunction induced by antidepressant medication" 3708: 3535: 3172: 3134: 3127: 3097: 2402: 2355: 2336: 2300:

There appears to be no significant difference in effectiveness between SSRIs and

2165: 1711: 1707: 1476: 1360: 674: 513: 291: 168: 14104: 13282: 12171: 11147:"Selective serotonin reuptake inhibitors as a novel class of immunosuppressants" 11120: 10987: 8735: 8718: 5435: 5412: 5262: 2327:(BDNF). BDNF enhances the growth and survival of cortical neurons and synapses. 2208: 657:

A number of non-SSRI drugs are not associated with sexual side effects (such as

17592: 17587: 17033: 16801: 16751: 16633: 16503: 16111: 16095: 16091: 16017: 15740: 15406: 15398: 15011: 14777: 14500: 14252: 13982: 13917: 13753: 13595: 13509: 13357: 13331: 13224: 12666: 12375: 12273: 12167: 12098: 11893: 11641: 10440:

Practice Guideline for the Treatment of Patients With Major Depressive Disorder

10410: 9786:

Proceedings of the National Academy of Sciences of the United States of America

9674: 9524: 9118: 6696: 6365: 6292: 6163: 6118: 5773: 5487: 5245: 5144: 4374: 3657: 3149: 3142: 3078: 2282: 2080: 1853: 1781: 1446: 1368: 1272: 1208: 1129: 1101: 1080: 986: 952: 824: 735: 635: 391: 283: 201: 197: 105: 11936: 11809: 11373: 10932: 10632: 10151: 9873: 9574: 9433: 9203: 8660: 8219: 8202: 8167:"Statistical Evaluation of Suicidality in Adults Treated with Antidepressants" 7756: 7667: 7572: 7321: 7304: 7166: 6639: 6602: 6585: 6502: 6206: 5686: 5008:"Antidepressant-associated sexual dysfunction: impact, effects, and treatment" 4933: 4840: 4823: 4772:. The National Institute for Health and Care Excellence (NICE). January 2004. 4641: 4624: 4528: 4511: 4496: 4455: 4026: 3991: 3812: 3795: 3669:. The National Institute for Health and Care Excellence (NICE). Archived from 3589: 684:

Several studies have suggested that SSRIs may adversely affect semen quality.

17731: 17477: 17253: 17023: 16776: 16736: 16367: 16151: 16147: 16117: 16083: 16057: 16047: 16002: 15966: 15826: 15770: 15609: 15549: 15471: 15451: 15434: 15412: 15333: 15328: 15278: 15242: 15102: 15041: 14767: 14287: 14272: 14232: 13862: 13747: 13724: 13542: 13504: 13483: 13114: 13061: 12849: 12721: 12696: 12691: 12631: 12606: 12106: 11786:, Aldred G (June 2005). "Antidepressant drug use & the risk of suicide". 10885: 10499: 9780:

Warner-Schmidt JL, Vanover KE, Chen EY, Marshall JJ, Greengard P (May 2011).

9262:"The use of psychotropic medication during pregnancy: how about the newborn?" 8614: 8565: 7887: 7710: 7204: 7092: 6300: 5670:"The effect of SSRIs on Semen quality: A systematic review and meta-analysis" 5187: 4888: 4250: 4070: 3754: 3327: 2305: 2193: 1699: 1232: 1204: 1052: 1044: 828: 813: 751: 374: 216: 16472: 14384: 14379: 12082: 11328:"Serotonin norepinephrine reuptake inhibitors: similarities and differences" 9981: 9798: 9327: 9005: 8955: 8904: 7278: 6888: 1156:

It is unclear whether SSRIs affect the risk of suicidal behavior in adults.

17667: 17652: 17632: 17607: 17043: 16936: 16786: 16678: 16673: 16593: 16568: 16302: 16197: 16187: 16012: 16007: 15851: 15821: 15709: 15579: 15457: 15369: 15338: 15293: 15288: 15283: 15127: 15097: 14985: 14894: 14854: 14757: 14677: 14567: 14557: 14369: 14364: 14349: 14344: 14323: 14080: 14049: 14003: 13832: 13822: 13812: 13791: 13714: 13657: 13612: 13499: 13321: 13159: 13147: 13057: 12964: 12894: 12884: 12736: 12726: 12626: 12621: 12544: 12539: 12519: 12504: 12458: 12220: 12184: 12114: 12059: 12001: 11944: 11901: 11866: 11817: 11769: 11734: 11649: 11541: 11503: 11381: 11305: 11262: 11221: 11172: 11128: 11090: 11052: 10995: 10940: 10893: 10858: 10809: 10790: 10758: 10696: 10640: 10604: 10518: 10258: 10218: 10169: 10120: 10071: 9997: 9923: 9817: 9758: 9723: 9682: 9639: 9593: 9542: 9482: 9441: 9406: 9363: 9297: 9246: 9211: 9126: 9091: 9050: 9023: 8990:"Risks of using SSRI / SNRI antidepressants during pregnancy and lactation" 8974: 8923: 8869: 8818: 8775: 8703: 8668: 8632: 8583: 8462: 8427: 8361: 8228: 8074: 8017: 7982: 7941: 7848: 7799: 7764: 7718: 7675: 7640: 7631: 7614: 7580: 7541: 7492: 7457: 7408: 7365: 7330: 7286: 7212: 7174: 7110: 7016: 6861: 6812: 6763: 6714: 6657: 6611: 6570: 6521: 6463: 6316:

PRAC recommendations on signals: Adopted at the 13-16 May 2019 PRAC meeting

6257: 6214: 6171: 6126: 6066: 6016: 5978: 5904: 5838: 5781: 5746: 5705: 5654: 5585: 5550: 5495: 5447: 5420: 5350: 5315: 5195: 5117: 5094: 5043: 4992: 4941: 4906: 4849: 4743: 4686: 4650: 4547: 4473: 4393: 4307: 4258: 4222: 4163:. The National Institute for Health and Care Excellence (NICE). June 2019. 4142: 4089: 4034: 3999: 3964: 3911: 3870: 3821: 3772: 3727: 3608: 3543: 3504: 3486: 3111: 3094: 2740: 2680: 2475: 2260: 1947: 1551: 1280: 1276: 1256: 1076: 904: 868: 497: 435: 419: 381:

The use of SSRIs in children with depression remains controversial. A 2021

366: 295: 65:, the neurotransmitter that is involved in the mechanism of action of SSRIs 15662:

Selective serotonin reuptake inhibitors and serotonin receptor modulators:

10379: 10336: 10301: 10250: 9958: 9950: 9473: 9456: 8419: 6896: 6843: 5385: 5230: 5152: 4954: 3250:

An SSRI (fluoxetine) has been approved for veterinary use in treatment of

934:

In a 2023 study a possible connection between SSRI usage and the onset of

334:(FDA) before licensing of four newer antidepressants (including the SSRIs 17702: 17682: 17672: 17637: 17597: 17497: 17428: 17393: 17388: 17378: 17210: 17146: 17101: 17096: 16931: 16891: 16806: 16796: 16771: 16688: 16643: 16608: 16372: 16362: 16307: 16278: 16228: 16172: 16125: 16107: 16042: 16022: 15971: 15961: 15936: 15896: 15891: 15836: 15806: 15785: 15775: 15765: 15725: 15664: 15644: 15634: 15614: 15594: 15554: 15544: 15491: 15420: 15402: 15374: 15359: 15318: 15298: 15247: 15237: 15212: 15172: 15167: 15112: 15082: 15061: 15051: 15036: 15001: 14965: 14930: 14859: 14849: 14839: 14834: 14782: 14762: 14752: 14727: 14707: 14637: 14612: 14587: 14582: 14577: 14542: 14537: 14495: 14490: 14439: 14247: 14092: 14070: 14034: 14011: 13842: 13827: 13817: 13795: 13737: 13694: 13672: 13493: 13479: 13427: 13402: 13397: 13077: 12974: 12839: 12774: 12769: 12759: 12716: 12701: 12686: 12676: 12646: 12636: 12509: 12479: 12474: 12420: 12397: 12392: 12364: 12321: 12298: 12288: 12230: 12136: 12025: 11726: 11203: 10586: 9750: 8009: 6745: 6648: 5737: 5720: 5668:

Xu J, He K, Zhou Y, Zhao L, Lin Y, Huang Z, Xie N, Yue J, Tang Y (2022).

5222: 4920:

Waldinger MD (November 2007). "Premature ejaculation: state of the art".

4187:"Optimal treatment of social phobia: systematic review and meta-analysis" 3090: 3074: 3050: 3040: 3020: 2990: 2980: 2950: 2944: 2933: 2915: 2906: 2760: 2692: 2541: 2216: 2084: 1995: 1691: 1601: 1441: 1378: 1352: 1324: 1141: 1118: 1040: 968: 864: 763: 759: 678: 670: 662: 595: 501: 482: 431: 415: 351: 13940: 12050: 11841:"Suicidality with selective serotonin reuptake inhibitors: Valid claim?" 10972: 8404: 8375: 7815:"SSRI-associated bruxism: A systematic review of published case reports" 6679:

Costagliola C, Parmeggiani F, Semeraro F, Sebastiani A (December 2008).

6678: 5895: 5056: 4801:"Practice guideline for the treatment of patients with eating disorders" 4157:"Depression in children and young people: identification and management" 4156: 3902: 3885: 3640: 3623: 3312:(Fifth ed.). Belmont, CA: Wadsworth Cengage Learning. p. 239. 3204:, introduced in 1987 is commonly thought the first SSRI to be marketed. 2323:(cAMP) on the postsynaptic neuronal cell, which leads to the release of 1873:

expressing neuroprotective actions to the neurotoxic abilities of MDMA.

738:. Additional non-sexual symptoms are also commonly described, including 57: 17697: 17642: 17577: 17572: 17472: 17403: 17383: 17348: 17343: 17338: 17308: 17258: 17215: 17180: 17131: 17126: 17086: 17053: 17048: 17038: 17018: 17013: 16946: 16921: 16746: 16693: 16683: 16648: 16617: 16603: 16578: 16573: 16553: 16548: 16421: 16377: 16342: 16269: 16232: 16192: 16162: 16139: 16103: 16052: 16037: 15921: 15906: 15876: 15866: 15861: 15816: 15811: 15750: 15745: 15730: 15704: 15674: 15669: 15654: 15649: 15624: 15619: 15589: 15584: 15564: 15559: 15483: 15462: 15445: 15440: 15323: 15313: 15197: 15182: 15152: 15142: 15137: 15092: 15087: 15021: 15016: 14975: 14955: 14940: 14915: 14899: 14874: 14869: 14747: 14737: 14722: 14667: 14657: 14647: 14627: 14617: 14602: 14597: 14520: 14510: 14505: 14318: 14211: 14206: 14088: 14084: 14019: 14015: 14007: 13999: 13857: 13785: 13732: 13709: 13704: 13687: 13627: 13585: 13570: 13452: 13407: 13392: 13372: 13367: 13362: 13278: 13195: 13181: 13167: 13073: 13069: 13065: 13019: 12989: 12984: 12979: 12959: 12929: 12919: 12879: 12864: 12844: 12731: 12711: 12681: 12661: 12641: 12601: 12549: 12534: 12529: 12489: 12453: 12425: 12354: 12331: 12326: 12278: 12250: 12245: 12240: 12225: 12215: 10136:"New FDA black box warning for codeine: how will this affect dentists?" 9630: 9278: 9066:"The fetal safety of fluoxetine: a systematic review and meta-analysis" 7066: 6249: 5960: 5531: 5024: 4203: 3288: 3201: 3193: 3164: 3160: 3107: 3070: 3030: 3000: 2938: 2921: 2885: 2849: 2822: 2796: 2780: 2770: 2750: 2730: 2704: 2698: 2686: 2674: 2607: 2576: 2506: 2433: 2264: 2185: 2112: 2100: 2041: 2017: 1973: 1925: 1824: 1803: 1731: 1727: 1651: 1626: 1576: 1526: 1364: 1356: 1137: 1063:

does not appear to heighten the risk of the serotonin syndrome. Taking

900: 797: 666: 647: 639: 615: 583:

SSRIs such as sertraline have been found to be effective in decreasing

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Rothmore J (April 2020). "Antidepressant-induced sexual dysfunction".

5108:

Stahl SM, Lonnen AJ (2011). "The Mechanism of Drug-induced Akathsia".

5075: 4973: 4489:"Review Finds SSRIs Modestly Effective in Short-Term Treatment of OCD" 3763: 3308:

Barlow DH, durand VM (2009). "Chapter 7: Mood Disorders and Suicide".

823:

On the 20th of march of 2024, a lawsuit was filed by the organization

785:, and should be distinguished from sexual dysfunction associated with 181: 17677: 17662: 17647: 17622: 17552: 17467: 17447: 17398: 17333: 17328: 17243: 17111: 17008: 16988: 16961: 16941: 16866: 16766: 16756: 16726: 16668: 16663: 16543: 16538: 16409: 16357: 16327: 16322: 16242: 16224: 16220: 16177: 16135: 16078: 16027: 15946: 15916: 15780: 15699: 15689: 15684: 15679: 15604: 15599: 15479: 15475: 15364: 15354: 15303: 15222: 15192: 15056: 15006: 14925: 14920: 14889: 14884: 14844: 14742: 14732: 14697: 14622: 14592: 14525: 14485: 14449: 14354: 14339: 14313: 14277: 14267: 14196: 14191: 14186: 14181: 13892: 13887: 13882: 13872: 13852: 13777: 13699: 13642: 13532: 13514: 13489: 13462: 13447: 13442: 13437: 13432: 13377: 13311: 13247: 13083: 12969: 12904: 12899: 12874: 12869: 12859: 12854: 12764: 12706: 12671: 12651: 12616: 12572: 12430: 12387: 12359: 12293: 12235: 11253: 11236: 10688: 10200: 10053: 9316: 5886: 4865:"Selective serotonin reuptake inhibitors (SSRIs) for stroke recovery" 4510:

Fineberg NA, Brown A, Reghunandanan S, Pampaloni I (September 2012).

3010: 2927: 2875: 2843: 2660: 2233: 2212: 2181: 2173: 2144: 2127:. Fluvoxamine has by far the strongest activity of the SSRIs at the σ 1869: 1723: 1715: 1461: 1431: 1404: 1343: 1316: 1292: 1048: 1024: 924: 860: 743: 688: 658: 651: 643: 599: 223: 129: 62: 14026: 13634: 13619: 12408: 12261: 11680:

10.1002/1099-1077(200008)15:6<471::AID-HUP211>3.0.CO;2-4

11188:"Selective serotonin reuptake inhibitors ameliorate MEGF10 myopathy" 10772:

Kishimoto A, Todani A, Miura J, Kitagaki T, Hashimoto K (May 2010).

8716: 5719:

Koyuncu H, Serefoglu EC, Ozdemir AT, Hellstrom WJ (September 2012).

5512: 4538: 1108:

found statistically significant increases of the risks of "possible

1067:(MAOIs) in combination with SSRIs can be fatal, since MAOIs disrupt 81:

Serotonin-specific reuptake inhibitors, serotonergic antidepressants

17657: 17612: 17502: 17462: 17457: 17373: 17220: 17081: 16713: 16708: 16698: 16396: 16347: 16337: 16236: 16182: 16143: 16121: 15911: 15901: 15694: 15487: 15430: 15416: 15187: 15177: 14879: 14864: 14829: 14687: 14682: 14672: 14642: 14444: 14201: 13867: 13847: 13767: 13580: 13524: 13467: 13457: 13422: 13412: 13387: 13316: 12834: 12790: 12514: 12499: 12342: 7556: 5805:"Off-label Uses of Selective Serotonin Reuptake Inhibitors (SSRIs)" 4707: 4509: 3519: 2177: 1757: 1719: 1703: 1467: 1394: 1060: 956: 939: 899:

changes related to SSRI use. The recommended maximum daily dose of

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Ener RA, Meglathery SB, Van Decker WA, Gallagher RM (March 2003).

9661:

Walkup J, Labellarte M (2001). "Complications of SSRI treatment".

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Journal of the American Academy of Child and Adolescent Psychiatry

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Dubovicky M, Belovicova K, Csatlosova K, Bogi E (September 2017).

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post-retinoid sexual dysfunction/post-Accutane syndrome (PRSD/PAS)

598:

vary among the individual drugs of this class. They may include

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Sigma Receptors: Their Role in Disease and as Therapeutic Targets

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Corruble E, de Bodinat C, Belaïdi C, Goodwin GM (November 2013).

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lower rates of suicide in children, though since the evidence is

1056: 1023:

Serotonin syndrome is typically caused by the use of two or more

1006: 964: 76: 10976:

Progress in Neuro-Psychopharmacology & Biological Psychiatry

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Tarchi L, Merola GP, Baccaredda-Boy O, et al. (June 2023).

5718: 4437: 3689: 3658:

National Collaborating Centre for Mental Health (October 2009).

1690:

The CYP2D6 enzyme is entirely responsible for the metabolism of

808:(EMA) recommended that packaging leaflets of selected SSRIs and 17288: 17273: 17190: 17151: 17116: 16993: 16911: 16906: 16871: 16831: 16533: 16212: 15941: 15886: 15629: 15467: 15217: 15162: 14970: 14717: 14394: 13991: 13877: 13604: 12380:

Tooltip Noradrenergic and specific serotonergic antidepressants

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Women's Mental Health, An Issue of Psychiatric Clinics – E-Book

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Riggin L, Frankel Z, Moretti M, Pupco A, Koren G (April 2013).

5057:

Romero-Martínez Á, Murciano-Martí S, Moya-Albiol L (May 2019).

4440:"Antidepressants versus placebo for depression in primary care" 3927: 3468: 2559: 2524: 2458: 2454: 2405: 1519: 1514: 1509: 1499: 1494: 1479: 848: 731: 715: 623: 539: 10871: 10531: 9833:

Goodman and Gilman's The Pharmacological Basis of Therapeutics

7785: 6624: 6192: 4807:. U.S. Department of Health and Human Services. Archived from 3923: 3921: 2119:

receptor. None of the SSRIs have significant affinity for the

17248: 17175: 16826: 16528: 12571: 11747: 11144: 8885: 8596: 6278: 5287: 4710:"Antidepressants versus placebo for panic disorder in adults" 4625:"Evidence-based pharmacotherapy of panic disorder: an update" 3520:"Antidepressants work, sort of – our system of care does not" 3412:"Depression and Serotonin: What the New Review Actually Says" 3101: 3086: 3066: 1820: 1399: 1320: 1036: 809: 584: 11702: 11467: 11185: 11016: 10771: 10314: 9856:

Ciraulo DA, Shader RI (2011). Ciraulo DA, Shader RI (eds.).

9737:

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9039:

Journal of Population Therapeutics and Clinical Pharmacology

8717:

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7996:

Boyer EW, Shannon M (March 2005). "The serotonin syndrome".

7264: 7190: 6825: 6435: 3835:

Gibbons RD, Hur K, Brown CH, Davis JM, Mann JJ (June 2012).

3570: 3284:

Serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI)

2215:

which are specialized macrophages that reside in the brain.

17225: 16718: 16286: 12441: 11966:

Gibbons RD, Brown CH, Hur K, Davis J, Mann JJ (June 2012).

10182: 5759: 4106: 3918: 2245: 1861: 1857: 1773: 1383: 1300: 998: 14808: 12309: 10534:

Goodman and Gilman's pharmacological basis of therapeutics

10403:

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5949:

The International Journal of Risk & Safety in Medicine

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Jannini TB, Lorenzo GD, Bianciardi E, et al. (2022).

1055:. Concomitant use of SSRIs or SNRIs for depression with a 13556: 10726: 10724: 10722: 10720: 10718: 10716: 10714: 9063: 8325: 8275:"Antidepressant Use in Children, Adolescents, and Adults" 7861: 5990: 5988: 4663: 3385:. In Preskorn SH, Feighner HP, Stanga CY, Ross R (eds.). 1191: 558:

effects of SSRIs generally take several weeks to emerge.

430:

is not considered to be effective for this disorder. The

238:. They have varying degrees of selectivity for the other 16257: 11519: 11234: 11145:

Gobin V, Van Steendam K, Denys D, Deforce D (May 2014).

10532:

Goodman LS, Brunton LL, Chabner B, Knollmann BC (2001).

10432: 10430: 10232: 10230: 10228: 9936: 8752: 7870:. Abstract of the 25th European Congress of Psychiatry. 7302: 6993: 5802: 4235: 3884:

Hieronymus F, Lisinski A, Näslund J, Eriksson E (2018).

1315:, SSRIs may cause a bipolar switch from depression into 1286: 642:; for decreased libido, possibly adding or switching to 16584: 11561:

Lexicon of Psychiatry, Neurology, and the Neurosciences

10914: 10825:"Separation of ascorbic acid and 2-keto-L-gulonic acid" 10617: 10279: 10236: 10087:"Immunisation and pregnancy – who, what, when and why?" 9189: 9036: 7653: 6352:"SSRIs, SNRIs: risk of persistent sexual dysfunction". 4821: 4622: 4354: 3624:"Understanding and treating depersonalisation disorder" 3621: 2143:

receptor by fluvoxamine may have beneficial effects on

15799:

Serotonin–norepinephrine–dopamine reuptake inhibitors:

15075:

Serotonin–norepinephrine–dopamine reuptake inhibitors:

13344: 10711: 10273: 9830: 7788:

Journal of Musculoskeletal & Neuronal Interactions

6819: 5985: 5941: 5399:

Balon R (2006). "SSRI-Associated Sexual Dysfunction".

4319: 4317: 3740: 3269:

Noradrenergic and specific serotonergic antidepressant

3200:

among treated patients led to its withdrawal in 1983.

2240:(cAMP) as a result of interference with activation of 796:

Reports of PSSD have occurred with almost every SSRI (

17226: 16719: 15518: 13972: 11423: 10427: 10225: 9698:"Serotonin syndrome and other serotonergic disorders" 8839: 8440: 6149: 4757: 4755: 4753: 1167:

and compared to therapeutic interventions other than

911:. In overdose, fluoxetine has been reported to cause 477:

In Canada, SSRIs are a first-line treatment of adult

14155: 14031:

Tooltip Serotonin-norepinephrine reuptake inhibitors

13679: 13639:

Tooltip Serotonin antagonist and reuptake inhibitors

13624:

Tooltip Serotonin-norepinephrine reuptake inhibitors

12413:

Tooltip Serotonin antagonist and reuptake inhibitors

12266:

Tooltip Serotonin–norepinephrine reuptake inhibitors

11965: 11627: 11564:. Lippincott Williams & Wilkins. pp. 581–. 11468:

Bruno A, Morabito P, Spina E, Muscatello MR (2016).

10446:(third ed.). American Psychiatric Association. 9454: 9141:"Breastfeeding Update: SDCBC's quarterly newsletter" 8886:

Nikfar S, Rahimi R, Hendoiee N, Abdollahi M (2012).

8684:

The Australian and New Zealand Journal of Psychiatry

7954: 7696: 4828:

The International Journal of Neuropsychopharmacology

4824:"Evidence-based pharmacotherapy of eating disorders" 4629:

The International Journal of Neuropsychopharmacology

4516:

The International Journal of Neuropsychopharmacology

3834: 3800:

The International Journal of Neuropsychopharmacology

2147:. In contrast to fluvoxamine, the relevance of the σ 1844:

into the sending presynaptic cell, a process called

1262: 971:, and post operative bleeding. The relative risk of 17409: 13664: 12747: 12347:

Tooltip Norepinephrine–dopamine reuptake inhibitors

12080: 11668:

Human Psychopharmacology: Clinical and Experimental

10351: 8936: 8547: 8277:. U.S. Food and Drug Administration. Archived from 8200: 6964:"Clinical and ECG Effects of Escitalopram Overdose" 6951:

Medicines and Healthcare products Regulatory Agency

6104: 5753: 4623:Batelaan NM, Van Balkom AJ, Stein DJ (April 2012). 4314: 4006: 3971: 2139:(PET) research. It is thought that agonism of the σ 1126:

Medicines and Healthcare products Regulatory Agency

646:; and for overall sexual dysfunction, switching to 538:SSRIs have been used off-label in the treatment of 426:are used off-label with acceptable efficacy, while 14797: 11879: 11594: 11592: 11396: 10674: 10308: 10084: 9663:Journal of Child and Adolescent Psychopharmacology 9259: 8408:Journal of Child and Adolescent Psychopharmacology 8038: 7862:Prisco V, Iannaccone T, Di Grezia G (2017-04-01). 7514:Eom CS, Lee HK, Ye S, Park SM, Cho KH (May 2012). 4750: 3793: 3380: 3279:Serotonin–norepinephrine reuptake inhibitor (SNRI) 3230:continued to do so after the warnings were added. 2067:(nM). The smaller the value, the more strongly the 1121:, the true nature of the relationship is unclear. 17354: 17062: 14134: 14041: 13649: 12589: 12083:"Selective serotonin reuptake inhibitor exposure" 10730: 7239:The Maudsley prescribing guidelines in psychiatry 7236: 4822:Flament MF, Bissada H, Spettigue W (March 2012). 1295:exposure to SSRIs may increase the risk of ASDs ( 816:"could neither confirm nor rule out a causal link 445: 316:National Institute for Health and Care Excellence 242:, with pure SSRIs having strong affinity for the 17729: 12812: 11623: 11621: 11515: 11513: 11429: 11140: 11138: 11068: 10670: 10668: 10666: 10664: 10662: 10660: 10658: 9979: 9660: 9455:Hviid A, Melbye M, Pasternak B (December 2013). 9166:"Using Antidepressants in Breastfeeding Mothers" 8937:Eke AC, Saccone G, Berghella V (November 2016). 8748: 8746: 8094:. Elsevier Health Sciences. pp. 1154–1155. 7554: 5005: 4862: 3787: 1882:SSRIs at the human SERT and rat sigma receptors 1814: 1698:and dihydrocodeine to their active metabolites ( 1051:(intermittent jerking or twitching), as well as 472: 13996:Tooltip Selective serotonin reuptake inhibitors 13609:Tooltip Selective serotonin reuptake inhibitors 13149: 12208:Tooltip Selective serotonin reuptake inhibitors 12132:WebMD – Selective Serotonin Reuptake Inhibitors 11589: 11321: 11319: 11317: 11315: 11102: 11100: 10822: 9982:"Opioid pharmacokinetic drug-drug interactions" 9502: 9500: 8548:Gunnell D, Saperia J, Ashby D (February 2005). 8164: 7615:"Drugs that may harm bone: Mitigating the risk" 7343: 7260: 7258: 6776: 6479: 6477: 6475: 6473: 5176:Journal of the American Pharmacists Association 4184: 4012: 3977: 3622:Medford N, Sierra M, Baker D, David AS (2005). 3171:receptor antagonist while lubazodone is also a 1710:, respectively), which in turn undergo phase 2 1246: 702: 457: 348:serotonin and norepinephrine reuptake inhibitor 302:(PTSD). They are also frequently used to treat 17364: 17072: 11661: 11659: 8201:Olfson M, Marcus SC, Shaffer D (August 2006). 7919: 7303:de Abajo FJ, García-Rodríguez LA (July 2008). 6537:"Antidepressants: misnamed and misrepresented" 6285:Social Psychiatry and Psychiatric Epidemiology 6100: 6098: 5563: 5173: 5006:Higgins A, Nash M, Lynch AM (September 2010). 4045: 3081:(Pristiq) are in fact relatively selective as 2391: 2367: 2281:Large bodies of research are devoted to using 1687:+++ – strong/potent inhibition 1222: 1190:In 2016 a study criticized the effects of the 714:The reported symptoms of PSSD include reduced 270:; however, they are frequently prescribed for 16502: 16488: 15723:Serotonin–norepinephrine reuptake inhibitors: 15507: 14999:Serotonin–norepinephrine reuptake inhibitors: 14827:Selective norepinephrine reuptake inhibitors: 14120: 13956: 13263: 12152: 12081:Fitzgerald KT, Bronstein AC (February 2013). 11696: 11618: 11510: 11461: 11402: 11135: 11064: 11062: 10655: 10555: 10553: 9897: 9895: 9893: 9855: 8743: 8645: 8512: 8434: 8032: 7812: 7421: 7152: 6145: 6143: 6141: 6139: 5937: 5935: 5933: 5864: 5862: 5860: 5858: 5856: 5854: 5852: 5850: 5848: 3685: 3683: 2412: 2381: 1891: 14913:Norepinephrine–dopamine reuptake inhibitors: 14144: 11406:Medical Pharmacology and Therapeutics E-Book 11312: 11097: 10823:Bafna SL, Patel DJ, Mehta JD (August 1972). 10085:Wiley K, Regan A, McIntyre P (August 2017). 9736: 9497: 9104: 9070:Journal of Obstetrics and Gynaecology Canada 7995: 7513: 7424:"Influence of antidepressants on hemostasis" 7337: 7255: 6770: 6618: 6577: 6528: 6470: 6429: 6412:"FDA Sued Over Inaction on Citizen Petition" 6345: 6229: 5667: 5661: 5640: 5506: 5466: 5328: 5167: 5101: 5050: 4999: 4948: 4913: 4815: 4229: 3310:Abnormal Psychology: An Integrative Approach 3307: 2158: 1426:Serotonin-norepinephrine reuptake inhibitors 13549: 13183: 13000: 12940: 12446:Tooltip Serotonin modulator and stimulators 11782: 11656: 11553: 11551: 11436:. Elsevier Health Sciences. pp. 389–. 11409:. Elsevier Health Sciences. pp. 302–. 10536:. New York: McGraw-Hill. pp. 459–461. 10394: 9980:Overholser BR, Foster DR (September 2011). 9835:(12th ed.). McGraw Hill Professional. 8332:The Cochrane Database of Systematic Reviews 8091:Ferri's Clinical Advisor 2017: 5 Books in 1 7742: 7612: 7232: 7230: 7186: 7184: 6186: 6095: 5796: 5725:International Journal of Impotence Research 5433: 5427: 5294:The Cochrane Database of Systematic Reviews 5202: 5124: 5107: 4869:The Cochrane Database of Systematic Reviews 4714:The Cochrane Database of Systematic Reviews 4444:The Cochrane Database of Systematic Reviews 4113:The Cochrane Database of Systematic Reviews 3653: 3651: 3374: 1790: 1486:Cytochrome P450 enzyme inhibition by SSRIs 1275:with PPHN have high pressure in their lung 1148:. Fluoxetine is not licensed for this use. 1091: 802:Pharmacovigilance Risk Assessment Committee 32:"SSRI" redirects here. For other uses, see 17748:Treatment of obsessive–compulsive disorder 16495: 16481: 14813:Tooltip Norepinephrine reuptake inhibitors 14127: 14113: 13963: 13949: 13270: 13256: 12314:Tooltip Norepinephrine reuptake inhibitors 12166: 12159: 12145: 11359: 11059: 10550: 10282:The American Journal of Emergency Medicine 10239:Journal of Toxicology. Clinical Toxicology 9890: 9562:International Journal of Bipolar Disorders 8293:"FDA Medication Guide for Antidepressants" 8128: 7386: 6136: 5930: 5845: 4051: 3794:Fountoulakis KN, Möller HJ (August 2010). 3734: 3680: 3464: 3462: 2115:does not significantly interact with the σ 891:SSRIs do not appear to affect the risk of 833:United States Food and Drug Administration 438:) of SSRIs in terms of improvement on the 397: 314:Antidepressants are recommended by the UK 13970: 12049: 11991: 11856: 11799: 11776: 11716: 11493: 11252: 11235:Rasmussen-Torvik LJ, McAlpine DD (2007). 11211: 11162: 11042: 10848: 10799: 10789: 10594: 10508: 10498: 10208: 10159: 10110: 10061: 10012:"Paroxetine hydrochloride – Drug Summary" 9939:European Journal of Clinical Pharmacology 9831:Brunton L, Chabner B, Knollman B (2010). 9807: 9797: 9713: 9629: 9583: 9573: 9532: 9472: 9353: 9312:Persistent Newborn Pulmonary Hypertension 9287: 9277: 9107:Seminars in Fetal & Neonatal Medicine 9081: 9013: 8964: 8954: 8913: 8903: 8734: 8681: 8622: 8573: 8351: 8218: 8064: 8039:Orlova Y, Rizzoli P, Loder E (May 2018). 7972: 7955:Volpi-Abadie J, Kaye AM, Kaye AD (2013). 7838: 7738: 7736: 7630: 7555:Bruyère O, Reginster JY (February 2015). 7531: 7447: 7320: 7298: 7296: 7146: 7100: 6851: 6802: 6753: 6721: 6704: 6672: 6647: 6601: 6560: 6534: 6511: 6501: 6483: 6453: 6031: 5968: 5894: 5828: 5736: 5695: 5685: 5540: 5530: 5305: 5261: 5084: 5074: 5033: 5023: 4982: 4972: 4919: 4896: 4839: 4763:"Eating disorders in over 8s: management" 4733: 4640: 4537: 4527: 4463: 4383: 4373: 4297: 4279: 4212: 4202: 4132: 4079: 4069: 3954: 3901: 3860: 3811: 3762: 3717: 3707: 3639: 3598: 3588: 3494: 3387:Antidepressants: Past, Present and Future 3383:"Selective Serotonin Reuptake Inhibitors" 1876: 976:cirrhosis of the liver or liver failure. 16262:Tooltip Vesicular monoamine transporters 15537:Selective serotonin reuptake inhibitors: 13041: 11845:Journal of Psychiatry & Neuroscience 11838: 11548: 11283: 8124: 8122: 8081: 7470: 7227: 7181: 7155:The Psychiatric Clinics of North America 6874: 6783:British Journal of Clinical Pharmacology 6727: 6235: 3648: 3342:"Mechanism of Action of Antidepressants" 2653:Neurotransmitter transporters inhibitors 2648: 1714:. These opioids (and to a lesser extent 546: 17738:Selective serotonin reuptake inhibitors 16624:Dehydroepiandrosterone sulfate (DHEA-S) 16589:Tooltip Calcitonin gene-related peptide 13292: 12008: 11325: 9419: 8892:DARU Journal of Pharmaceutical Sciences 8194: 6868: 5606: 5243: 5237: 3459: 3381:Preskorn SH, Ross R, Stanga CY (2004). 3189:Development and discovery of SSRI drugs 3114:(Trintellix) are SRIs that also act as 3100:(Fetzima) are the only widely marketed 2356: 1685:++ – moderate inhibition 1683:+ – mild/weak inhibition 775:antidepressant discontinuation syndrome 190:Selective serotonin reuptake inhibitors 14: 17730: 13349:Tooltip positive allosteric modulators 13332: 13277: 11665: 10480: 10357: 10133: 9555: 9266:Neuropsychiatric Disease and Treatment 9260:Kieviet N, Dolman KM, Honig A (2013). 8321: 8319: 8241: 7733: 7293: 5566:Journal of Clinical Psychopharmacology 5434:Wilson TK, Tripp J (17 January 2023). 5371: 5331:Journal of Clinical Psychopharmacology 4191:Neuropsychiatric Disease and Treatment 3524:Journal of Clinical Psychopharmacology 3434: 3409: 3389:. Berlin: Springer. pp. 241–262. 2312:. Further, they have fewer and milder 1809: 212:, and other psychological conditions. 42:Selective serotonin reuptake inhibitor 16476: 15523:Tooltip Serotonin reuptake inhibitors 14108: 13944: 13251: 13136: 13040: 12811: 12570: 12183: 12140: 11630:Current Topics in Medicinal Chemistry 10400: 10035: 9901: 8158: 8119: 8087: 6037: 5398: 4922:The Urologic Clinics of North America 4486: 3428: 3301: 3233: 2319:SSRIs act on signal pathways such as 1831:, a small gap between the cells. The 1287:Neuropsychiatric effects in offspring 1012: 967:. This includes an increased risk of 838: 605: 134: 14160:Tooltip Dopamine reuptake inhibitors 13684:Tooltip Monoamine oxidase inhibitors 11604:. Birkhäuser. 2012. pp. 80–82. 10562: 9986:The American Journal of Managed Care 8796: 8235: 8165:Levenson M, Holland C (2006-11-17). 7813:Garrett AR, Hawley JS (April 2018). 7619:Cleveland Clinic Journal of Medicine 7520:Journal of Bone and Mineral Research 7237:Taylor D, Carol P, Shitij K (2012). 5130: 4593:"Paroxetine prescribing information" 4562:"Sertraline prescribing information" 3566: 3564: 3517: 3124:serotonin modulators and stimulators 2900: 2837: 1335:The following drugs may precipitate 1009:on SSRI/SNRI induced jaw clenching. 418:were later approved for it as well. 330:35 clinical trials submitted to the 17414:Tooltip 3,4,5-Trimethoxyamphetamine 13669:Tooltip Tetracyclic antidepressants 12752:Tooltip Tetracyclic antidepressants 12087:Topics in Companion Animal Medicine 11984:10.1001/archgenpsychiatry.2011.2048 11705:The New England Journal of Medicine 11557: 10014:. Physicians' Desk Reference, LLC. 9824: 9739:The New England Journal of Medicine 9461:The New England Journal of Medicine 9143:. Breastfeeding.org. Archived from 8316: 7998:The New England Journal of Medicine 6909: 6360:(5). Springer: 5. 16 January 2021. 5454:from the original on 11 August 2020 5208: 5012:Drug, Healthcare and Patient Safety 4185:Canton J, Scott KM, Glue P (2012). 3853:10.1001/archgenpsychiatry.2011.2044 3511: 2330: 2270: 791:persistent genital arousal disorder 507: 24: 15857:Didesmethylsibutramine (BTS-54505) 15133:Didesmethylsibutramine (BTS-54505) 14802:Tooltip Norepinephrine transporter 14563:Didesmethylsibutramine (BTS-54505) 11882:The American Journal of Psychiatry 11788:International Review of Psychiatry 9864:(2nd ed.). Springer. p. 9610:The American Journal of Psychiatry 8443:The American Journal of Psychiatry 7613:Hant FN, Bolster MB (April 2016). 7428:Dialogues in Clinical Neuroscience 7267:The Journal of Clinical Psychiatry 6730:"SSRI-associated optic neuropathy" 5401:The American Journal of Psychiatry 5374:The Journal of Clinical Psychiatry 5211:The Journal of Clinical Psychiatry 3667:NICE clinical guidelines 90 and 91 3660:"Depression Quick Reference Guide" 2668: 843:Certain antidepressants may cause 695:blockade) is a notorious cause of 533: 27:Class of antidepressant medication 25: 17764: 17588:Chlorphenamine (chlorpheniramine) 17359:Tooltip N,N-Diisopropyltryptamine 17067:Tooltip N,N-Diisopropyltryptamine 14375:Etybenzatropine (ethybenztropine) 14046:Tooltip Tricyclic antidepressants 13654:Tooltip Tricyclic antidepressants 13137: 12594:Tooltip Tricyclic antidepressants 12125: 11534:10.2174/0929867324666170712165042 11486:10.2174/1570159x14666151117122458 11430:Kornstein SG, Clayton AH (2010). 10841:10.2174/1570159X14666151208113700 9192:Archives of Women's Mental Health 8129:Stone MB, Jones ML (2006-11-17). 7009:10.2174/0929867306666220330184544 6333:from the original on 20 July 2023 5821:10.2174/1570159X19666210517150418 3628:Advances in Psychiatric Treatment 3561: 3447:from the original on 12 July 2011 3245: 2895: 2325:brain-derived neurotrophic factor 2131:receptor. High occupancy of the σ 1306: 1263:Persistent pulmonary hypertension 1098:U.S. Food and Drug Administration 907:was reduced due to concerns with 730:in females, difficulty having an 610:SSRIs can cause various types of 519:Similar recommendations apply to 500:was more effective than placebo. 488: 306:, although with varying results. 266:The main indication for SSRIs is 15847:Desmethylsibutramine (BTS-54354) 15123:Desmethylsibutramine (BTS-54354) 14553:Desmethylsibutramine (BTS-54354) 12074: 11959: 11916: 11873: 11832: 11750:Journal of Clinical Epidemiology 11741: 11353: 11277: 11228: 11179: 11151:International Immunopharmacology 11083:10.1016/j.pharmthera.2016.04.001 11010: 10966: 10908: 10865: 10816: 10765: 10611: 10525: 10474: 10372:10.2165/00002018-199513020-00004 10176: 10127: 10078: 10029: 10004: 9973: 9930: 9849: 9773: 9730: 9715:10.1046/j.1526-4637.2003.03005.x 9689: 9654: 9600: 9549: 9448: 9413: 9370: 9321: 9304: 9253: 9226: 9183: 9158: 9133: 9098: 9057: 9030: 8981: 8930: 8833: 8790: 8710: 8696:10.1111/j.1440-1614.2006.01917.x 8675: 8639: 8590: 8541: 8477: 8398: 8386:from the original on 31 May 2022 8368: 8285: 8267: 7989: 7948: 7913: 7855: 7806: 7779: 7690: 7647: 7606: 7548: 7507: 7485:10.2165/11589340-000000000-00000 7464: 7440:10.31887/DCNS.2007.9.1/dhalperin 7415: 7389:The American Journal of Medicine 7241:. West Sussex: Wiley-Blackwell. 4805:National Guideline Clearinghouse 3242:findings near human settlement. 3060: 3045: 3035: 3025: 3015: 3005: 2995: 2985: 2975: 2880: 2870: 2817: 2775: 2765: 2755: 2745: 2735: 2725: 2639: 2624:CYP2B6 (CYP2C19, CYP3A4, CYP2D6) 2164:inflammatory conditions such as 1681:0 – no inhibition 1251:Several studies have documented 1198: 979: 56: 16458:Monoamine metabolism modulators 11578:from the original on 2023-01-14 11450:from the original on 2023-01-14 11342:from the original on 2020-08-07 11071:Pharmacology & Therapeutics 10955:from the original on 2020-08-07 10463:from the original on 2020-08-07 10018:from the original on 2018-09-28 8723:Archives of Clinical Psychiatry 8501:from the original on 2008-02-28 8305:from the original on 2014-08-18 8256:from the original on 2008-06-25 8183:from the original on 2007-03-16 8147:from the original on 2007-03-16 8108:from the original on 2023-01-14 7902:from the original on 2020-10-10 7595:from the original on 2020-10-10 7380: 7135:from the original on 2024-02-12 7117: 7060: 7049:from the original on 2024-02-12 7031: 6987: 6976:from the original on 2013-10-21 6956: 6933: 6922:from the original on 2020-10-10 6903: 6832:New England Journal of Medicine 6404: 6380: 6307: 6272: 6084:from the original on 2024-03-22 5919:from the original on 2023-07-20 5712: 5634: 5600: 5557: 5392: 5365: 5322: 5281: 5270:from the original on 2021-04-15 4856: 4779:from the original on 2014-03-27 4701: 4657: 4616: 4605:from the original on 2015-02-19 4585: 4574:from the original on 2015-06-16 4554: 4503: 4480: 4431: 4413:. November 2005. Archived from 4400: 4348: 4273: 4178: 4167:from the original on 2022-12-26 4149: 4100: 3877: 3828: 3550:from the original on 2017-09-13 3437:"In Defense of Antidepressants" 3274:Serotonin releasing agent (SRA) 2832: 2028: 1966: 1961: 1330: 1086: 800:is an exception). In 2019, the 764:post-finasteride syndrome (PFS) 590: 261: 246:and only weak affinity for the 17369:Tooltip N,N-Dipropyltryptamine 17077:Tooltip N,N-Dipropyltryptamine 16777:Pentoxyverine (carbetapentane) 11972:Archives of General Psychiatry 11839:Lapierre YD (September 2003). 11762:10.1016/j.jclinepi.2015.08.021 11286:Journal of Affective Disorders 9904:Expert Opin Drug Metab Toxicol 9622:10.1176/appi.ajp.2014.13111501 9422:Journal of Affective Disorders 9399:10.1016/j.reprotox.2012.04.015 9168:. kellymom.com. Archived from 8862:10.1016/j.reprotox.2006.03.019 8649:Journal of Affective Disorders 8344:10.1002/14651858.CD008324.pub3 8207:Archives of General Psychiatry 7309:Archives of General Psychiatry 7073:Science Translational Medicine 5643:Current Women's Health Reports 5476:The Journal of Sexual Medicine 5307:10.1002/14651858.CD003382.pub3 4881:10.1002/14651858.CD009286.pub4 4726:10.1002/14651858.CD010676.pub2 4125:10.1002/14651858.CD013674.pub2 3841:Archives of General Psychiatry 3615: 3403: 3334: 3207: 2396:Tooltip Plasma protein binding 2375:Tooltip Volume of distribution 2321:cyclic adenosine monophosphate 2288: 2238:cyclic adenosine monophosphate 1144:(Luvox), for the treatment of 927:. Some authors have suggested 779:post-acute withdrawal syndrome 446:Post-traumatic stress disorder 440:Liebowitz social anxiety scale 342:, the non-SSRI antidepressant 13: 1: 17718:Receptor/signaling modulators 16614:Dehydroepiandrosterone (DHEA) 16438:Receptor/signaling modulators 15512:Tooltip Serotonin transporter 14136:Monoamine reuptake inhibitors 11931:(2): 73–90, discussion 91–8. 11403:Waller DG, Sampson T (2017). 11298:10.1016/S0165-0327(99)00092-0 10874:Journal of Psychopharmacology 10329:10.1016/S0140-6736(05)64513-8 9916:10.1080/17425255.2019.1669560 9860:Pharmacotherapy of Depression 9083:10.1016/S1701-2163(15)30965-8 7880:10.1016/j.eurpsy.2017.01.1701 7699:The Annals of Pharmacotherapy 7193:Expert Opinion on Drug Safety 6953:. Article date: December 2011 6728:Lochhead J (September 2015). 6009:10.1080/14740338.2022.2007883 5997:Expert Opinion on Drug Safety 5133:Journal of Psychopharmacology 4679:10.1016/s0165-1781(01)00265-7 3947:10.1016/S0140-6736(17)32802-7 3743:Journal of Psychopharmacology 3294: 3083:serotonin reuptake inhibitors 2420:Tooltip Elimination half-life 2386:Tooltip Partition coefficient 2248:and Notch signaling pathway. 2205:tumor necrosis factor (TNF)-α 1896:Tooltip Serotonin transporter 1823:, messages are passed from a 1815:Serotonin reuptake inhibition 1797:SSRI discontinuation syndrome 1146:obsessive–compulsive disorder 709:serotonin reuptake-inhibiting 578: 479:obsessive–compulsive disorder 473:Obsessive–compulsive disorder 402:Some SSRIs are effective for 309: 300:posttraumatic stress disorder 288:obsessive–compulsive disorder 15352:Tetracyclic antidepressants: 14149:Tooltip Dopamine transporter 12814:Monoamine oxidase inhibitors 12042:10.1016/j.envres.2018.12.048 11164:10.1016/j.intimp.2014.02.030 10778:Annals of General Psychiatry 10741:10.1007/978-3-319-50174-1_11 10294:10.1016/0735-6757(92)90041-U 10103:10.18773/austprescr.2017.046 8994:Interdisciplinary Toxicology 8811:10.1097/FTD.0b013e31826d07ea 8526:. 2005-09-29. Archived from 8455:10.1176/appi.ajp.163.11.1898 8298:Food and Drug Administration 8057:10.1001/jamaneurol.2017.5144 7934:10.1097/WNF.0b013e3182227736 7831:10.1212/CPJ.0000000000000433 7819:Neurology. Clinical Practice 7745:Current Osteoporosis Reports 7422:Halperin D, Reber G (2007). 7401:10.1016/j.amjmed.2005.03.044 7358:10.1212/WNL.0b013e318271f848 7085:10.1126/scitranslmed.adc9606 6535:Moncrieff J (October 2015). 6484:Ma H, Cai M, Wang H (2021). 6059:10.12968/bjon.2023.32.14.678 5578:10.1097/JCP.0b013e3181a5233f 5519:Journal of Clinical Medicine 5343:10.1097/jcp.0b013e31819c76e9 4487:Busko M (28 February 2008). 4280:Alexander W (January 2012). 3709:10.1371/journal.pmed.0050045 3536:10.1097/JCP.0b013e3181d52dea 3137:while vortioxetine is a 5-HT 2137:positron emission tomography 1349:Monoamine oxidase inhibitors 1311:In adults and children with 1253:neonatal abstinence syndrome 1247:Neonatal abstinence syndrome 1213:cardiovascular complications 1065:monoamine oxidase inhibitors 703:Post-SSRI sexual dysfunction 464:generalized anxiety disorder 458:Generalized anxiety disorder 332:Food and Drug Administration 280:generalized anxiety disorder 7: 16802:Racemethorphan (methorphan) 15802:3,3-Diphenylcyclobutanamine 15078:3,3-Diphenylcyclobutanamine 13008:Tooltip Monoamine oxidase B 12948:Tooltip Monoamine oxidase A 12577:tetracyclic antidepressants 11522:Current Medicinal Chemistry 11121:10.1016/j.imbio.2016.07.001 10988:10.1016/j.pnpbp.2017.04.026 9556:Gitlin MJ (December 2018). 8799:Therapeutic Drug Monitoring 8736:10.1590/0101-60830000000086 6997:Current Medicinal Chemistry 6877:Archives of Family Medicine 6326:. 11 June 2019. p. 5. 5413:10.1176/appi.ajp.163.9.1504 5407:(9): 1504–1509, quiz 1664. 5263:10.2174/1874350100801010042 5250:The Open Psychology Journal 3349:Psychopharmacology Bulletin 3257: 2644: 2257:inflammatory bowel diseases 1745: 1223:Pregnancy and breastfeeding 946: 200:that are typically used as 10: 17769: 16442:Monoamine releasing agents 16000:Tricyclic antidepressants: 15276:Tricyclic antidepressants: 14345:Benzatropine (benztropine) 12485:Dextromethorphan/bupropion 12099:10.1053/j.tcam.2013.03.003 11894:10.1176/appi.ajp.160.4.790 11642:10.2174/156802606778249810 9675:10.1089/104454601750143320 9525:10.1016/j.jaac.2016.02.013 9119:10.1016/j.siny.2012.10.004 7922:Clinical Neuropharmacology 6697:10.2174/157015908787386104 6590:Int J Neuropsychopharmacol 6366:10.1007/s40278-021-89324-7 6293:10.1007/s00127-024-02769-0 6164:10.1016/j.sxmr.2021.07.001 6119:10.1016/j.sxmr.2017.07.002 5875:Pharmacoepidemiol Drug Saf 5774:10.1016/j.sxmr.2018.09.002 5619:(1): 55–61. Archived from 5488:10.1016/j.jsxm.2021.05.016 5182:(2): e28–36, quiz e37–38. 5145:10.1177/026988119801200212 4375:10.1186/1471-244X-14-S1-S1 3211: 3186: 3182: 2274: 1794: 1749: 1016: 993: 936:mitral valve regurgitation 886: 573:becomes the desired effect 550: 358:pharmaceutical industries. 304:depersonalization disorder 298:, and, in some cases, for 31: 17711: 17437: 17160: 16513: 16430: 16386: 16255: 16066: 15995: 15794: 15718: 15532: 15505: 15383: 15347: 15271: 15070: 14994: 14908: 14822: 14795: 14478: 14332: 14296: 14220: 14169: 14142: 14059: 13981: 13901: 13805: 13746: 13723: 13594: 13541: 13523: 13330: 13290: 13208: 13143: 13132: 13049: 13036: 12998: 12938: 12824: 12820: 12807: 12783: 12745: 12587: 12583: 12566: 12467: 12439: 12406: 12373: 12340: 12307: 12259: 12201: 12197: 12179: 11937:10.1191/1740774506cn139oa 11810:10.1080/09540260500071624 11674:(6). Austin, Texas: 471. 11601:Progress in Drug Research 11474:Current Neuropharmacology 11374:10.1017/s1092852900028297 10933:10.1007/s12035-017-0632-1 10829:Current Neuropharmacology 10633:10.1007/s12035-016-0342-0 10487:Frontiers in Pharmacology 10152:10.2344/0003-3006-60.2.35 9874:10.1007/978-1-60327-435-7 9575:10.1186/s40345-018-0133-9 9434:10.1016/j.jad.2015.04.048 9204:10.1007/s00737-007-0173-0 8661:10.1016/j.jad.2006.04.003 8249:. FDA. pp. 42, 115. 8220:10.1001/archpsyc.63.8.865 7757:10.1007/s11914-016-0322-3 7668:10.1007/s40266-015-0323-4 7573:10.1007/s12020-014-0357-0 7322:10.1001/archpsyc.65.7.795 7167:10.1016/j.psc.2016.04.010 6685:Current Neuropharmacology 6640:10.1016/j.jad.2020.11.106 6603:10.1017/S1461145713000679 6503:10.3389/fpsyt.2021.792960 6324:European Medicines Agency 6207:10.1007/s12020-018-1593-5 5687:10.3389/fphar.2022.911489 5674:Frontiers in Pharmacology 4934:10.1016/j.ucl.2007.08.011 4841:10.1017/S1461145711000381 4642:10.1017/S1461145711000800 4529:10.1017/S1461145711001829 4456:10.1002/14651858.CD007954 4027:10.1016/j.cct.2015.05.005 3992:10.1016/j.cct.2006.10.012 3813:10.1017/S1461145710000957 3590:10.1186/s12888-016-1173-2 3252:canine separation anxiety 3240:environmental contaminant 3214:Biopsychiatry controversy 2970: 2865: 2812: 2790: 2720: 2302:tricyclic antidepressants 2159:Anti-inflammatory effects 2062: 1899: 1420:Tricyclic antidepressants 1297:autism spectrum disorders 1169:tricyclic antidepressants 1151: 1106:major depressive disorder 874: 806:European Medicines Agency 783:major depressive disorder 693:alpha adrenergic receptor 268:major depressive disorder 206:major depressive disorder 180: 175: 161: 156: 142: 128: 123: 111: 99: 90:Major depressive disorder 85: 75: 70: 55: 46: 41: 16679:Fabomotizole (afobazole) 16654:Dimethyltryptamine (DMT) 15726:Atomoxetine (tomoxetine) 15002:Atomoxetine (tomoxetine) 13191:Rubidium chloride (RbCl) 11192:Human Molecular Genetics 11023:Translational Psychiatry 10886:10.1177/0269881115609072 10677:Human Psychopharmacology 10500:10.3389/fphar.2013.00045 8615:10.1136/bmj.330.7488.396 8566:10.1136/bmj.330.7488.385 8242:Hammad TA (2004-08-16). 8176:. FDA. pp. 75–140. 7711:10.1177/1060028015569594 7205:10.1517/14740338.4.2.337 5188:10.1331/JAPhA.2009.08083 4928:(4): 591–599, vii–viii. 4251:10.1177/0269881106065102 4071:10.3389/fpsyt.2017.00275 3755:10.1177/0269881110372544 3093:(Ixel, Savella) and its 2293:SSRIs are described as ' 2069:drug binds to the site. 1791:Discontinuation syndrome 1092:Children and adolescents 1027:drugs, including SSRIs. 691:(an antidepressant with 626:, genital numbness, and 17753:Treatment of depression 17643:Mepyramine (pyrilamine) 17324:3-Methoxydextrallorphan 16984:3-Methoxydextrallorphan 16807:Racemorphan (morphanol) 16104:mepyramine (pyrilamine) 14077:Atypical antipsychotics 13301:Tooltip 5-HT1A receptor 13054:Atypical antipsychotics 10575:Neuropsychopharmacology 10413:. pp. xii + 1438. 10042:Mayo Clinic Proceedings 9799:10.1073/pnas.1104836108 9379:Reproductive Toxicology 9235:Danish Medical Bulletin 9006:10.1515/intox-2017-0004 8956:10.1111/1471-0528.14144 8905:10.1186/2008-2231-20-75 8842:Reproductive Toxicology 8140:. FDA. pp. 11–74. 7279:10.4088/JCP.09r05786blu 6889:10.1001/archfami.7.1.78 6107:Sexual Medicine Reviews 5762:Sexual Medicine Reviews 3435:Kramer P (7 Sep 2011). 3410:Rettew D (2022-07-26). 3264:List of antidepressants 3198:Guillain–Barré syndrome 3126:(SMS). Vilazodone is a 2361:Tooltip Bioavailability 2221:Peripheral inflammation 398:Social anxiety disorder 276:social anxiety disorder 17743:Sigma receptor ligands 17698:Tiospirone (BMY-13859) 17638:Gevotroline (WY-47384) 17563:18-Methoxycoronaridine 17550:Allosteric modulators: 17309:Panamesine (EMD-57455) 17259:Siramesine (Lu 28-179) 17196:Ditolylguanidine (DTG) 16959:Allosteric modulators: 16922:Panamesine (EMD-57455) 16867:BMY-14802 (BMS-181100) 16659:Ditolylguanidine (DTG) 16639:Dextromethorphan (DXM) 16378:Vanoxerine (GBR-12909) 16225:pethidine (meperidine) 15480:pethidine (meperidine) 14268:Pethidine (meperidine) 14067:Typical antipsychotics 13341:Tooltip GABAA receptor 12018:Environmental Research 11241:Depression and Anxiety 10921:Molecular Neurobiology 10791:10.1186/1744-859X-9-23 10621:Molecular Neurobiology 10036:Smith HS (July 2009). 9992:(Suppl 11): S276–287. 7632:10.3949/ccjm.83a.15066 4052:Hengartner MP (2017). 3890:Acta Neuropsychiatrica 3676:on September 28, 2013. 3487:10.1001/jama.2009.1943 3065:Although described as 2665: 2663:transporter inhibitors 1877:Sigma receptor ligands 1842:monoamine transporters 1756:SSRIs appear safer in 1269:pulmonary hypertension 1217:cardiovascular disease 893:coronary heart disease 240:monoamine transporters 16969:Methylphenylpiracetam 16544:Alazocine (SKF-10047) 16462:Monoamine neurotoxins 16028:Dosulepin (dothiepin) 15575:Didesmethylcitalopram 15304:Dosulepin (dothiepin) 14981:Serdexmethylphenidate 14283:Serdexmethylphenidate 11368:(7 Suppl 11): 27–33. 10251:10.1081/CLT-120037428 10091:Australian Prescriber 9951:10.1007/s002280050163 9474:10.1056/NEJMoa1301449 8420:10.1089/cap.2006.0138 6910:FDA (December 2018). 6844:10.1056/NEJMoa1312828 6038:Marks S (July 2023). 3518:Pies R (April 2010). 3218:Biological psychiatry 3141:receptor agonist and 3122:and are described as 2652: 2275:Further information: 973:intracranial bleeding 917:myocardial infarction 553:Premature ejaculation 547:Premature ejaculation 521:binge eating disorder 252:dopamine transporters 244:serotonin transporter 118:Serotonin transporter 34:SSRI (disambiguation) 16792:Pregnenolone sulfate 16604:Cutamesine (SA-4503) 16353:Methoxytetrabenazine 16318:Dihydrotetrabenazine 16132:Arylcyclohexylamines 15427:Arylcyclohexylamines 14578:Dizocilpine (MK-801) 14532:Chaenomeles speciosa 14233:Benocyclidine (BTCP) 13576:Gabapentin enacarbil 13175:Hypericum perforatum 13043:Adjunctive therapies 11727:10.1056/NEJMsa065779 10587:10.1038/npp.2013.120 9751:10.1056/NEJMra041867 9147:on February 25, 2009 8756:Psychother Psychosom 8010:10.1056/nejmra041867 7957:"Serotonin syndrome" 7043:NewYork-Presbyterian 6746:10.1038/eye.2015.119 6442:Clin Neuropsychiatry 5738:10.1038/ijir.2012.12 5223:10.4088/jcp.v57n1002 4161:NICE guideline NG134 3941:(10128): 1357–1366. 2335:SSRIs vary in their 2170:rheumatoid arthritis 1764:Because of the wide 1405:Pethidine/meperidine 1339:in people on SSRIs: 1033:increased heart rate 929:electrocardiographic 756:cognitive impairment 726:in males or loss of 724:erectile dysfunction 620:erectile dysfunction 234:(reuptake) into the 204:in the treatment of 16942:Rimcazole (BW-234U) 15977:Threohydrobupropion 15842:Desmethylsertraline 15570:Desmethylcitalopram 15253:Threohydrobupropion 15118:Desmethylsertraline 14773:Threohydrobupropion 14548:Desmethylsertraline 12191:receptor modulators 12187:reuptake inhibitors 12034:2019ER....170..422C 11326:Shelton RC (2009). 10140:Anesthesia Progress 10038:"Opioid metabolism" 9391:2012RepTx..34..293T 8854:2006RepTx..22..571R 8382:. 28 October 2009. 7961:The Ochsner Journal 7868:European Psychiatry 5809:Curr Neuropharmacol 5607:Clayton AH (2003). 5244:Bahrick AS (2008). 5063:Behavioral Sciences 4770:Clinical guideline 4667:Psychiatry Research 4015:Contemp Clin Trials 3980:Contemp Clin Trials 3903:10.1017/neu.2017.23 3641:10.1192/apt.11.2.92 3120:serotonin receptors 2348: 1883: 1810:Mechanism of action 1487: 879:Acute narrow-angle 728:vaginal lubrication 215:SSRIs increase the 16699:Igmesine (JO-1784) 16628:prasterone sulfate 16217:dextropropoxyphene 14243:Dexmethylphenidate 13928:Never to phase III 13235:Never to phase III 11332:Primary Psychiatry 11204:10.1093/hmg/ddz064 10134:Weaver JM (2013). 9279:10.2147/NDT.S36394 8690:(11–12): 941–950. 8281:on 7 January 2017. 6945:2013-03-06 at the 6250:10.5694/mja2.50522 5961:10.3233/JRS-210023 5613:Primary Psychiatry 5532:10.3390/jcm8101640 5025:10.2147/DHPS.S7634 4499:on April 13, 2013. 4204:10.2147/NDT.S23317 3441:The New York Times 3234:In other organisms 2924:(Malexil; FG-4963) 2666: 2342: 2253:multiple sclerosis 2209:interferon (IFN)-γ 2194:interleukin (IL)-6 1881: 1770:serotonin syndrome 1752:Serotonin syndrome 1485: 1351:(MAOIs) including 1337:serotonin syndrome 1134:risk-benefit ratio 1100:(FDA) analysis of 1029:Serotonin syndrome 1019:Serotonin syndrome 1013:Serotonin syndrome 961:antiplatelet drugs 921:junctional rhythms 845:emotional blunting 839:Emotional blunting 612:sexual dysfunction 606:Sexual dysfunction 560:Sexual dysfunction 17725: 17724: 17560:Unknown/unsorted: 17321:Unknown/unsorted: 17056: 16981:Unknown/unsorted: 16644:Dextrorphan (DXO) 16470: 16469: 16465: 16251: 16250: 15526: 15501: 15500: 14946:Levophacetoperane 14816: 14791: 14790: 14653:Levophacetoperane 14228:4-Fluoropethidine 14163: 14102: 14101: 13975:pharmacotherapies 13938: 13937: 13510:Ethanol (alcohol) 13418:Ethyl loflazepate 13245: 13244: 13204: 13203: 13177:(St. John's Wort) 13128: 13127: 13093:lithium carbonate 13032: 13031: 13028: 13027: 12803: 12802: 12799: 12798: 12612:Amitriptylinoxide 12562: 12561: 12558: 12557: 11636:(17): 1801–1823. 11611:978-3-0348-8391-7 11571:978-0-7817-2468-5 11443:978-1-4557-0061-5 11416:978-0-7020-7190-4 11198:(14): 2365–2377. 11035:10.1038/tp.2012.8 10982:(Pt C): 217–226. 10750:978-3-319-50172-7 10581:(11): 2209–2219. 10543:978-0-07-162442-8 10481:Renoir T (2013). 10453:978-0-89042-338-7 10420:978-0-12-385926-6 10323:(9023): 339–340. 9883:978-1-60327-435-7 9842:978-0-07-162442-8 9792:(22): 9262–9267. 9745:(11): 1112–1120. 9616:(10): 1067–1073. 9467:(25): 2406–2415. 9346:10.1136/bmj.f6932 8949:(12): 1900–1907. 8768:10.1159/000477940 8449:(11): 1898–1904. 8101:978-0-323-44838-3 8088:Ferri FF (2016). 8004:(11): 1112–1120. 7656:Drugs & Aging 7533:10.1002/jbmr.1554 7473:Drugs & Aging 7352:(18): 1862–1865. 7273:(12): 1565–1575. 7248:978-0-470-97969-3 7079:(677): eadc9606. 6912:"FDA Drug Safety" 6838:(25): 2397–2407. 6795:10.1111/bcp.12383 6596:(10): 2219–2234. 6553:10.1002/wps.20243 5881:(10): 1053–1067. 5076:10.3390/bs9050057 4974:10.3390/ph3010019 4325:"www.nice.org.uk" 4239:J Psychopharmacol 3749:(10): 1277–1288. 3396:978-3-540-43054-4 3319:978-0-495-09556-9 3238:SSRIs are common 3163:(SL 81–0385) and 3056: 3055: 2891: 2890: 2828: 2827: 2786: 2785: 2637: 2636: 2073: 2072: 1827:to another via a 1766:therapeutic index 1675: 1674: 1110:suicidal ideation 1104:on children with 1069:monoamine oxidase 913:sinus tachycardia 829:Dr. Antonei Csoka 748:depersonalization 740:emotional numbing 320:cognitive therapy 272:anxiety disorders 210:anxiety disorders 187: 186: 113:Biological target 94:anxiety disorders 71:Class identifiers 16:(Redirected from 17760: 17415: 17411: 17370: 17366: 17360: 17356: 17229:(midomafetamine) 17228: 17078: 17074: 17068: 17064: 17054: 16722:(midomafetamine) 16721: 16590: 16586: 16497: 16490: 16483: 16474: 16473: 16432: 16419:Antagonist-like: 16313:Deutetrabenazine 16263: 16259: 16203:MIN-117 (WF-516) 16168:Dextromethorphan 15540:6-Nitroquipazine 15530: 15529: 15524: 15520: 15515: 15513: 15509: 14936:Hydroxybupropion 14820: 14819: 14814: 14810: 14805: 14803: 14799: 14693:MIN-117 (WF-516) 14633:Hydroxybupropion 14573:Diphenylpyraline 14304:Diphenylprolinol 14167: 14166: 14161: 14157: 14152: 14150: 14146: 14129: 14122: 14115: 14106: 14105: 14047: 14043: 14032: 14028: 13997: 13993: 13974: 13965: 13958: 13951: 13942: 13941: 13774:Alpha-2 agonists 13764:Alpha-1 blockers 13757: 13685: 13681: 13670: 13666: 13655: 13651: 13640: 13636: 13625: 13621: 13610: 13606: 13564: 13558: 13555: 13383:Chlordiazepoxide 13350: 13346: 13342: 13338: 13302: 13298: 13272: 13265: 13258: 13249: 13248: 13185: 13151: 13134: 13133: 13107:triiodothyronine 13103:Thyroid hormones 13038: 13037: 13009: 13005: 12949: 12945: 12890:Phenoxypropazine 12822: 12821: 12809: 12808: 12753: 12749: 12595: 12591: 12585: 12584: 12568: 12567: 12447: 12443: 12414: 12410: 12381: 12377: 12348: 12344: 12315: 12311: 12267: 12263: 12209: 12205: 12199: 12198: 12181: 12180: 12161: 12154: 12147: 12138: 12137: 12119: 12118: 12078: 12072: 12071: 12053: 12012: 12006: 12005: 11995: 11963: 11957: 11956: 11920: 11914: 11913: 11877: 11871: 11870: 11860: 11836: 11830: 11829: 11803: 11780: 11774: 11773: 11745: 11739: 11738: 11720: 11700: 11694: 11693: 11663: 11654: 11653: 11625: 11616: 11615: 11596: 11587: 11586: 11584: 11583: 11555: 11546: 11545: 11517: 11508: 11507: 11497: 11465: 11459: 11458: 11456: 11455: 11427: 11421: 11420: 11400: 11394: 11393: 11357: 11351: 11350: 11348: 11347: 11323: 11310: 11309: 11281: 11275: 11274: 11256: 11254:10.1002/da.20251 11232: 11226: 11225: 11215: 11183: 11177: 11176: 11166: 11142: 11133: 11132: 11104: 11095: 11094: 11066: 11057: 11056: 11046: 11014: 11008: 11007: 10970: 10964: 10963: 10961: 10960: 10927:(5): 4195–4206. 10912: 10906: 10905: 10869: 10863: 10862: 10852: 10835:(8): 1333–1334. 10820: 10814: 10813: 10803: 10793: 10769: 10763: 10762: 10728: 10709: 10708: 10689:10.1002/hup.1106 10672: 10653: 10652: 10615: 10609: 10608: 10598: 10566: 10560: 10557: 10548: 10547: 10529: 10523: 10522: 10512: 10502: 10478: 10472: 10471: 10469: 10468: 10462: 10445: 10434: 10425: 10424: 10401:Gupta R (2012). 10398: 10392: 10391: 10355: 10349: 10348: 10312: 10306: 10305: 10277: 10271: 10270: 10234: 10223: 10222: 10212: 10201:10.1136/bmj.c693 10180: 10174: 10173: 10163: 10131: 10125: 10124: 10114: 10082: 10076: 10075: 10065: 10054:10.4065/84.7.613 10033: 10027: 10026: 10024: 10023: 10008: 10002: 10001: 9977: 9971: 9970: 9934: 9928: 9927: 9899: 9888: 9887: 9863: 9853: 9847: 9846: 9828: 9822: 9821: 9811: 9801: 9777: 9771: 9770: 9734: 9728: 9727: 9717: 9693: 9687: 9686: 9658: 9652: 9651: 9633: 9604: 9598: 9597: 9587: 9577: 9553: 9547: 9546: 9536: 9504: 9495: 9494: 9476: 9452: 9446: 9445: 9417: 9411: 9410: 9374: 9368: 9367: 9357: 9325: 9319: 9308: 9302: 9301: 9291: 9281: 9257: 9251: 9250: 9230: 9224: 9223: 9187: 9181: 9180: 9178: 9177: 9162: 9156: 9155: 9153: 9152: 9137: 9131: 9130: 9102: 9096: 9095: 9085: 9061: 9055: 9054: 9034: 9028: 9027: 9017: 8985: 8979: 8978: 8968: 8958: 8934: 8928: 8927: 8917: 8907: 8883: 8874: 8873: 8837: 8831: 8830: 8794: 8788: 8787: 8750: 8741: 8740: 8738: 8714: 8708: 8707: 8679: 8673: 8672: 8643: 8637: 8636: 8626: 8594: 8588: 8587: 8577: 8545: 8539: 8538: 8536: 8535: 8516: 8510: 8509: 8507: 8506: 8500: 8489: 8481: 8475: 8474: 8438: 8432: 8431: 8402: 8396: 8395: 8393: 8391: 8372: 8366: 8365: 8355: 8338:(11): CD008324. 8323: 8314: 8313: 8311: 8310: 8289: 8283: 8282: 8271: 8265: 8264: 8262: 8261: 8255: 8248: 8239: 8233: 8232: 8222: 8198: 8192: 8191: 8189: 8188: 8182: 8171: 8162: 8156: 8155: 8153: 8152: 8146: 8135: 8126: 8117: 8116: 8114: 8113: 8085: 8079: 8078: 8068: 8036: 8030: 8029: 7993: 7987: 7986: 7976: 7952: 7946: 7945: 7917: 7911: 7910: 7908: 7907: 7859: 7853: 7852: 7842: 7810: 7804: 7803: 7783: 7777: 7776: 7740: 7731: 7730: 7694: 7688: 7687: 7651: 7645: 7644: 7634: 7610: 7604: 7603: 7601: 7600: 7552: 7546: 7545: 7535: 7526:(5): 1186–1195. 7511: 7505: 7504: 7468: 7462: 7461: 7451: 7419: 7413: 7412: 7384: 7378: 7377: 7341: 7335: 7334: 7324: 7300: 7291: 7290: 7262: 7253: 7252: 7234: 7225: 7224: 7188: 7179: 7178: 7150: 7144: 7143: 7141: 7140: 7121: 7115: 7114: 7104: 7064: 7058: 7057: 7055: 7054: 7035: 7029: 7028: 6991: 6985: 6984: 6982: 6981: 6975: 6968: 6960: 6954: 6937: 6931: 6930: 6928: 6927: 6907: 6901: 6900: 6872: 6866: 6865: 6855: 6823: 6817: 6816: 6806: 6774: 6768: 6767: 6757: 6740:(9): 1233–1235. 6725: 6719: 6718: 6708: 6676: 6670: 6669: 6651: 6622: 6616: 6615: 6605: 6581: 6575: 6574: 6564: 6541:World Psychiatry 6532: 6526: 6525: 6515: 6505: 6490:Front Psychiatry 6481: 6468: 6467: 6457: 6433: 6427: 6426: 6424: 6423: 6408: 6402: 6401: 6399: 6398: 6384: 6378: 6377: 6354:Reactions Weekly 6349: 6343: 6342: 6340: 6338: 6332: 6321: 6311: 6305: 6304: 6276: 6270: 6269: 6233: 6227: 6226: 6190: 6184: 6183: 6147: 6134: 6133: 6102: 6093: 6092: 6090: 6089: 6083: 6044: 6035: 6029: 6028: 5992: 5983: 5982: 5972: 5939: 5928: 5927: 5925: 5924: 5898: 5887:10.1002/pds.5653 5866: 5843: 5842: 5832: 5800: 5794: 5793: 5757: 5751: 5750: 5740: 5716: 5710: 5709: 5699: 5689: 5665: 5659: 5658: 5638: 5632: 5631: 5629: 5628: 5604: 5598: 5597: 5561: 5555: 5554: 5544: 5534: 5510: 5504: 5503: 5501:antidepressants. 5482:(8): 1354–1363. 5470: 5464: 5463: 5461: 5459: 5431: 5425: 5424: 5396: 5390: 5389: 5369: 5363: 5362: 5326: 5320: 5319: 5309: 5285: 5279: 5278: 5276: 5275: 5265: 5241: 5235: 5234: 5206: 5200: 5199: 5171: 5165: 5164: 5128: 5122: 5121: 5105: 5099: 5098: 5088: 5078: 5054: 5048: 5047: 5037: 5027: 5003: 4997: 4996: 4986: 4976: 4952: 4946: 4945: 4917: 4911: 4910: 4900: 4875:(11): CD009286. 4860: 4854: 4853: 4843: 4819: 4813: 4812: 4797: 4788: 4787: 4785: 4784: 4778: 4767: 4759: 4748: 4747: 4737: 4705: 4699: 4698: 4661: 4655: 4654: 4644: 4620: 4614: 4613: 4611: 4610: 4604: 4597: 4589: 4583: 4582: 4580: 4579: 4573: 4566: 4558: 4552: 4551: 4541: 4531: 4522:(8): 1173–1191. 4507: 4501: 4500: 4495:. Archived from 4484: 4478: 4477: 4467: 4435: 4429: 4428: 4426: 4425: 4419: 4412: 4404: 4398: 4397: 4387: 4377: 4352: 4346: 4345: 4343: 4342: 4336: 4330:. Archived from 4329: 4321: 4312: 4311: 4301: 4277: 4271: 4270: 4233: 4227: 4226: 4216: 4206: 4182: 4176: 4175: 4173: 4172: 4153: 4147: 4146: 4136: 4104: 4098: 4097: 4083: 4073: 4058:Front Psychiatry 4049: 4043: 4042: 4010: 4004: 4003: 3975: 3969: 3968: 3958: 3925: 3916: 3915: 3905: 3881: 3875: 3874: 3864: 3832: 3826: 3825: 3815: 3791: 3785: 3784: 3766: 3738: 3732: 3731: 3721: 3711: 3687: 3678: 3677: 3675: 3664: 3655: 3646: 3645: 3643: 3619: 3613: 3612: 3602: 3592: 3568: 3559: 3558: 3556: 3555: 3515: 3509: 3508: 3498: 3466: 3457: 3456: 3454: 3452: 3432: 3426: 3425: 3423: 3422: 3416:Psychology Today 3407: 3401: 3400: 3378: 3372: 3371: 3369: 3363:. Archived from 3346: 3338: 3332: 3331: 3305: 3049: 3039: 3029: 3019: 3009: 2999: 2989: 2979: 2968: 2967: 2964: 2957:)-norfluoxetine) 2884: 2874: 2863: 2862: 2859: 2821: 2810: 2809: 2806: 2779: 2769: 2759: 2749: 2739: 2729: 2718: 2717: 2714: 2658: 2421: 2417: 2397: 2393: 2387: 2383: 2376: 2372: 2362: 2358: 2349: 2345:pharmacokinetics 2341: 2331:Pharmacokinetics 2277:Pharmacogenetics 2271:Pharmacogenetics 2242:protein kinase A 2030: 1968: 1963: 1897: 1893: 1884: 1880: 1833:presynaptic cell 1829:chemical synapse 1782:cardiac toxicity 1488: 1484: 1464:(Advil, Nurofen) 1390:Dextromethorphan 1313:bipolar disorder 819: 628:sexual anhedonia 564:decreased libido 528:anorexia nervosa 508:Eating disorders 292:eating disorders 236:presynaptic cell 221:neurotransmitter 171: 152: 144:Consumer Reports 138: 60: 39: 38: 21: 17768: 17767: 17763: 17762: 17761: 17759: 17758: 17757: 17728: 17727: 17726: 17721: 17707: 17627:St. John's wort 17453:Ethylketazocine 17433: 17413: 17368: 17358: 17234:Methamphetamine 17165: 17156: 17142:Trifluoperazine 17076: 17066: 16742:Methylphenidate 16732:Methamphetamine 16588: 16518: 16509: 16501: 16471: 16466: 16426: 16404:DAT modulators: 16382: 16283:methamphetamine 16261: 16247: 16158:Cyclobenzaprine 16100:diphenhydramine 16088:brompheniramine 16062: 15991: 15790: 15756:Levomilnacipran 15714: 15522: 15514: 15511: 15497: 15395:brompheniramine 15379: 15343: 15267: 15066: 15027:Levomilnacipran 14990: 14961:Methylphenidate 14904: 14812: 14804: 14801: 14787: 14474: 14328: 14292: 14263:Methylphenidate 14238:Desoxypipradrol 14216: 14159: 14151: 14148: 14138: 14133: 14103: 14098: 14055: 14045: 14030: 13995: 13983:Antidepressants 13977: 13969: 13939: 13934: 13933: 13918:Clinical trials 13897: 13801: 13782:dexmedetomidine 13754:Antiadrenergics 13751: 13750: 13742: 13719: 13683: 13668: 13653: 13638: 13623: 13608: 13596:Antidepressants 13590: 13553: 13546: 13545: 13537: 13519: 13358:Benzodiazepines 13348: 13340: 13336: 13326: 13300: 13296: 13286: 13276: 13246: 13241: 13240: 13225:Clinical trials 13200: 13139: 13124: 13120: 13112: 13097:lithium citrate 13045: 13024: 13007: 13004: 12994: 12947: 12944: 12934: 12910:Tranylcypromine 12816: 12795: 12779: 12751: 12741: 12593: 12579: 12554: 12463: 12445: 12435: 12412: 12402: 12379: 12369: 12346: 12336: 12313: 12303: 12284:Levomilnacipran 12265: 12255: 12207: 12193: 12175: 12168:Antidepressants 12165: 12128: 12123: 12122: 12079: 12075: 12013: 12009: 11964: 11960: 11925:Clinical Trials 11921: 11917: 11878: 11874: 11837: 11833: 11801:10.1.1.482.5522 11781: 11777: 11746: 11742: 11701: 11697: 11690: 11664: 11657: 11626: 11619: 11612: 11598: 11597: 11590: 11581: 11579: 11572: 11558:Ayd FJ (2000). 11556: 11549: 11518: 11511: 11466: 11462: 11453: 11451: 11444: 11428: 11424: 11417: 11401: 11397: 11358: 11354: 11345: 11343: 11324: 11313: 11282: 11278: 11233: 11229: 11184: 11180: 11143: 11136: 11105: 11098: 11067: 11060: 11015: 11011: 10971: 10967: 10958: 10956: 10913: 10909: 10870: 10866: 10821: 10817: 10770: 10766: 10751: 10729: 10712: 10673: 10656: 10616: 10612: 10567: 10563: 10558: 10551: 10544: 10530: 10526: 10479: 10475: 10466: 10464: 10460: 10454: 10443: 10435: 10428: 10421: 10399: 10395: 10356: 10352: 10313: 10309: 10278: 10274: 10235: 10226: 10181: 10177: 10132: 10128: 10083: 10079: 10034: 10030: 10021: 10019: 10010: 10009: 10005: 9978: 9974: 9935: 9931: 9910:(10): 831–847. 9900: 9891: 9884: 9854: 9850: 9843: 9829: 9825: 9778: 9774: 9735: 9731: 9694: 9690: 9659: 9655: 9605: 9601: 9554: 9550: 9505: 9498: 9453: 9449: 9418: 9414: 9375: 9371: 9326: 9322: 9309: 9305: 9258: 9254: 9231: 9227: 9188: 9184: 9175: 9173: 9164: 9163: 9159: 9150: 9148: 9139: 9138: 9134: 9103: 9099: 9062: 9058: 9045:(2): e334–348. 9035: 9031: 8986: 8982: 8935: 8931: 8884: 8877: 8838: 8834: 8795: 8791: 8751: 8744: 8715: 8711: 8680: 8676: 8644: 8640: 8595: 8591: 8546: 8542: 8533: 8531: 8518: 8517: 8513: 8504: 8502: 8498: 8487: 8483: 8482: 8478: 8439: 8435: 8403: 8399: 8389: 8387: 8380:www.nice.org.uk 8374: 8373: 8369: 8324: 8317: 8308: 8306: 8291: 8290: 8286: 8273: 8272: 8268: 8259: 8257: 8253: 8246: 8240: 8236: 8199: 8195: 8186: 8184: 8180: 8169: 8163: 8159: 8150: 8148: 8144: 8133: 8127: 8120: 8111: 8109: 8102: 8086: 8082: 8037: 8033: 7994: 7990: 7953: 7949: 7918: 7914: 7905: 7903: 7860: 7856: 7811: 7807: 7784: 7780: 7741: 7734: 7695: 7691: 7652: 7648: 7611: 7607: 7598: 7596: 7553: 7549: 7512: 7508: 7469: 7465: 7420: 7416: 7385: 7381: 7342: 7338: 7301: 7294: 7263: 7256: 7249: 7235: 7228: 7189: 7182: 7151: 7147: 7138: 7136: 7123: 7122: 7118: 7065: 7061: 7052: 7050: 7037: 7036: 7032: 6992: 6988: 6979: 6977: 6973: 6966: 6962: 6961: 6957: 6947:Wayback Machine 6938: 6934: 6925: 6923: 6908: 6904: 6873: 6869: 6824: 6820: 6775: 6771: 6726: 6722: 6677: 6673: 6628:J Affect Disord 6623: 6619: 6582: 6578: 6533: 6529: 6482: 6471: 6434: 6430: 6421: 6419: 6410: 6409: 6405: 6396: 6394: 6386: 6385: 6381: 6351: 6350: 6346: 6336: 6334: 6330: 6319: 6313: 6312: 6308: 6277: 6273: 6234: 6230: 6191: 6187: 6148: 6137: 6103: 6096: 6087: 6085: 6081: 6053:(14): 678–682. 6042: 6036: 6032: 5993: 5986: 5940: 5931: 5922: 5920: 5867: 5846: 5801: 5797: 5758: 5754: 5717: 5713: 5666: 5662: 5639: 5635: 5626: 5624: 5605: 5601: 5562: 5558: 5511: 5507: 5471: 5467: 5457: 5455: 5432: 5428: 5397: 5393: 5370: 5366: 5327: 5323: 5300:(5): CD003382. 5286: 5282: 5273: 5271: 5242: 5238: 5217:(10): 449–454. 5207: 5203: 5172: 5168: 5129: 5125: 5106: 5102: 5055: 5051: 5004: 5000: 4961:Pharmaceuticals 4953: 4949: 4918: 4914: 4861: 4857: 4820: 4816: 4799: 4798: 4791: 4782: 4780: 4776: 4765: 4761: 4760: 4751: 4720:(4): CD010676. 4706: 4702: 4662: 4658: 4621: 4617: 4608: 4606: 4602: 4595: 4591: 4590: 4586: 4577: 4575: 4571: 4564: 4560: 4559: 4555: 4508: 4504: 4485: 4481: 4450:(3): CD007954. 4436: 4432: 4423: 4421: 4417: 4410: 4406: 4405: 4401: 4368:(Suppl 1): S1. 4353: 4349: 4340: 4338: 4334: 4327: 4323: 4322: 4315: 4278: 4274: 4234: 4230: 4183: 4179: 4170: 4168: 4155: 4154: 4150: 4119:(5): CD013674. 4105: 4101: 4050: 4046: 4011: 4007: 3976: 3972: 3926: 3919: 3882: 3878: 3833: 3829: 3792: 3788: 3739: 3735: 3688: 3681: 3673: 3662: 3656: 3649: 3620: 3616: 3569: 3562: 3553: 3551: 3516: 3512: 3467: 3460: 3450: 3448: 3433: 3429: 3420: 3418: 3408: 3404: 3397: 3379: 3375: 3367: 3355:. Summer 2002. 3344: 3340: 3339: 3335: 3320: 3306: 3302: 3297: 3260: 3248: 3236: 3220: 3210: 3191: 3185: 3176: 3170: 3153: 3146: 3140: 3135:partial agonist 3131: 3098:levomilnacipran 3077:(Effexor), and 3063: 3058: 3057: 2965: 2962: 2903: 2901:Antidepressants 2898: 2893: 2892: 2860: 2857: 2840: 2838:Antidepressants 2835: 2830: 2829: 2807: 2804: 2793: 2788: 2787: 2715: 2712: 2671: 2669:Antidepressants 2664: 2656: 2654: 2647: 2642: 2492:CYP3A4, CYP2C19 2428:Levels (ng/mL) 2419: 2416: 2395: 2385: 2374: 2371: 2360: 2337:pharmacokinetic 2333: 2291: 2283:genetic markers 2279: 2273: 2166:type 1 diabetes 2161: 2150: 2142: 2134: 2130: 2124: 2118: 2110: 2096: 2081:sigma receptors 2068: 2066: 1919: 1912: 1904: 1895: 1879: 1817: 1812: 1799: 1793: 1754: 1748: 1712:glucuronidation 1708:dihydromorphine 1686: 1684: 1682: 1680: 1477:P450 cytochrome 1410:St. John's wort 1361:tranylcypromine 1333: 1309: 1289: 1265: 1249: 1225: 1211:(+33%) and new 1201: 1154: 1102:clinical trials 1094: 1089: 1081:benzodiazepines 1079:, usually with 1021: 1015: 996: 982: 949: 909:QT prolongation 889: 877: 841: 827:, representing 817: 736:erogenous zones 705: 675:tranylcypromine 608: 593: 581: 555: 549: 536: 534:Stroke recovery 514:bulimia nervosa 510: 491: 475: 460: 448: 400: 312: 264: 202:antidepressants 167: 148: 66: 37: 28: 23: 22: 15: 12: 11: 5: 17766: 17756: 17755: 17750: 17745: 17740: 17723: 17722: 17712: 17709: 17708: 17706: 17705: 17700: 17695: 17690: 17685: 17680: 17675: 17670: 17665: 17660: 17655: 17650: 17645: 17640: 17635: 17630: 17620: 17615: 17610: 17605: 17600: 17595: 17593:Chlorpromazine 17590: 17585: 17580: 17575: 17570: 17565: 17556: 17555: 17546: 17545: 17540: 17535: 17530: 17525: 17520: 17515: 17510: 17505: 17500: 17495: 17490: 17481: 17480: 17475: 17470: 17465: 17460: 17455: 17450: 17441: 17439: 17435: 17434: 17432: 17431: 17426: 17421: 17416: 17406: 17401: 17396: 17391: 17386: 17381: 17376: 17371: 17361: 17351: 17346: 17341: 17336: 17331: 17326: 17317: 17316: 17311: 17306: 17301: 17296: 17291: 17286: 17281: 17276: 17267: 17266: 17261: 17256: 17251: 17246: 17241: 17236: 17231: 17223: 17218: 17213: 17208: 17203: 17198: 17193: 17188: 17183: 17178: 17169: 17167: 17163: 17158: 17157: 17155: 17154: 17149: 17144: 17139: 17134: 17129: 17124: 17119: 17114: 17109: 17104: 17099: 17094: 17089: 17084: 17079: 17069: 17059: 17051: 17046: 17041: 17036: 17034:Chlorpromazine 17031: 17026: 17021: 17016: 17011: 17006: 17001: 16996: 16991: 16986: 16977: 16976: 16971: 16955: 16954: 16949: 16944: 16939: 16934: 16929: 16924: 16919: 16914: 16909: 16904: 16899: 16894: 16889: 16887:E-52862 (S1RA) 16884: 16879: 16874: 16869: 16864: 16859: 16854: 16849: 16844: 16839: 16834: 16829: 16820: 16819: 16814: 16809: 16804: 16799: 16794: 16789: 16784: 16779: 16774: 16769: 16764: 16759: 16754: 16752:Neuropeptide Y 16749: 16744: 16739: 16734: 16729: 16724: 16716: 16711: 16706: 16701: 16696: 16691: 16686: 16681: 16676: 16671: 16666: 16661: 16656: 16651: 16646: 16641: 16636: 16634:Dextrallorphan 16631: 16621: 16611: 16606: 16601: 16596: 16591: 16581: 16576: 16571: 16566: 16561: 16556: 16551: 16546: 16541: 16536: 16531: 16522: 16520: 16516: 16511: 16510: 16504:Sigma receptor 16500: 16499: 16492: 16485: 16477: 16468: 16467: 16431: 16428: 16427: 16425: 16424: 16412: 16400: 16399: 16394:DAT enhancers: 16390: 16388: 16384: 16383: 16381: 16380: 16375: 16370: 16365: 16360: 16355: 16350: 16345: 16340: 16335: 16330: 16325: 16320: 16315: 16310: 16305: 16300: 16295: 16290: 16272: 16266: 16264: 16253: 16252: 16249: 16248: 16246: 16245: 16240: 16210: 16205: 16200: 16195: 16190: 16185: 16180: 16175: 16170: 16165: 16160: 16155: 16129: 16118:Antipsychotics 16115: 16112:tripelennamine 16096:dimenhydrinate 16092:chlorphenamine 16084:Antihistamines 16081: 16076: 16067: 16064: 16063: 16061: 16060: 16055: 16050: 16045: 16040: 16035: 16030: 16025: 16020: 16018:Cyanodothiepin 16015: 16010: 16005: 15996: 15993: 15992: 15990: 15989: 15979: 15974: 15969: 15964: 15959: 15954: 15949: 15944: 15939: 15934: 15929: 15924: 15919: 15914: 15909: 15904: 15899: 15894: 15889: 15884: 15879: 15874: 15869: 15864: 15859: 15854: 15849: 15844: 15839: 15834: 15829: 15824: 15819: 15814: 15809: 15804: 15795: 15792: 15791: 15789: 15788: 15783: 15778: 15773: 15768: 15763: 15758: 15753: 15748: 15743: 15741:Desvenlafaxine 15738: 15733: 15728: 15719: 15716: 15715: 15713: 15712: 15707: 15702: 15697: 15692: 15687: 15682: 15677: 15672: 15667: 15658: 15657: 15652: 15647: 15642: 15637: 15632: 15627: 15622: 15617: 15612: 15607: 15602: 15597: 15592: 15587: 15582: 15577: 15572: 15567: 15562: 15557: 15552: 15547: 15542: 15533: 15527: 15503: 15502: 15499: 15498: 15496: 15495: 15465: 15460: 15455: 15448: 15443: 15438: 15424: 15413:Antipsychotics 15410: 15407:tripelennamine 15399:chlorphenamine 15391:Antihistamines 15384: 15381: 15380: 15378: 15377: 15372: 15367: 15362: 15357: 15348: 15345: 15344: 15342: 15341: 15336: 15331: 15326: 15321: 15316: 15311: 15306: 15301: 15296: 15291: 15286: 15281: 15272: 15269: 15268: 15266: 15265: 15255: 15250: 15245: 15240: 15235: 15230: 15225: 15220: 15215: 15210: 15205: 15200: 15195: 15190: 15185: 15180: 15175: 15170: 15165: 15160: 15155: 15150: 15145: 15140: 15135: 15130: 15125: 15120: 15115: 15110: 15105: 15100: 15095: 15090: 15085: 15080: 15071: 15068: 15067: 15065: 15064: 15059: 15054: 15049: 15044: 15039: 15034: 15029: 15024: 15019: 15014: 15012:Desvenlafaxine 15009: 15004: 14995: 14992: 14991: 14989: 14988: 14983: 14978: 14973: 14968: 14963: 14958: 14953: 14948: 14943: 14938: 14933: 14928: 14923: 14918: 14909: 14906: 14905: 14903: 14902: 14897: 14892: 14887: 14882: 14877: 14872: 14867: 14862: 14857: 14852: 14847: 14842: 14837: 14832: 14823: 14817: 14793: 14792: 14789: 14788: 14786: 14785: 14780: 14778:Tripelennamine 14775: 14770: 14765: 14760: 14755: 14750: 14745: 14740: 14735: 14730: 14725: 14720: 14715: 14710: 14705: 14700: 14695: 14690: 14685: 14680: 14675: 14670: 14665: 14660: 14655: 14650: 14645: 14640: 14635: 14630: 14625: 14620: 14615: 14610: 14605: 14600: 14595: 14590: 14585: 14580: 14575: 14570: 14565: 14560: 14555: 14550: 14545: 14540: 14535: 14528: 14523: 14518: 14513: 14508: 14503: 14501:Amfonelic acid 14498: 14493: 14488: 14479: 14476: 14475: 14473: 14472: 14467: 14462: 14457: 14452: 14447: 14442: 14437: 14432: 14427: 14422: 14417: 14412: 14407: 14402: 14397: 14392: 14387: 14382: 14377: 14372: 14367: 14362: 14357: 14352: 14347: 14342: 14333: 14330: 14329: 14327: 14326: 14321: 14316: 14311: 14306: 14297: 14294: 14293: 14291: 14290: 14285: 14280: 14275: 14270: 14265: 14260: 14255: 14253:Ethylphenidate 14250: 14245: 14240: 14235: 14230: 14221: 14218: 14217: 14215: 14214: 14209: 14204: 14199: 14194: 14189: 14184: 14179: 14170: 14164: 14140: 14139: 14132: 14131: 14124: 14117: 14109: 14100: 14099: 14097: 14096: 14074: 14063: 14061: 14057: 14056: 14054: 14053: 14038: 14023: 13987: 13985: 13979: 13978: 13968: 13967: 13960: 13953: 13945: 13936: 13935: 13932: 13931: 13930: 13929: 13926: 13915: 13909: 13903: 13902: 13899: 13898: 13896: 13895: 13890: 13885: 13880: 13875: 13870: 13865: 13860: 13855: 13850: 13845: 13840: 13835: 13830: 13825: 13820: 13815: 13809: 13807: 13803: 13802: 13800: 13799: 13789: 13771: 13760: 13758: 13748:Sympatholytics 13744: 13743: 13741: 13740: 13735: 13729: 13727: 13725:Antipsychotics 13721: 13720: 13718: 13717: 13712: 13707: 13702: 13697: 13676: 13661: 13646: 13631: 13616: 13600: 13598: 13592: 13591: 13589: 13588: 13583: 13578: 13573: 13567: 13565: 13551: 13543:Gabapentinoids 13539: 13538: 13536: 13535: 13529: 13527: 13521: 13520: 13518: 13517: 13512: 13507: 13502: 13497: 13487: 13477: 13465: 13460: 13455: 13450: 13445: 13440: 13435: 13430: 13425: 13420: 13415: 13410: 13405: 13400: 13395: 13390: 13385: 13380: 13375: 13370: 13365: 13353: 13351: 13334: 13328: 13327: 13325: 13324: 13319: 13314: 13308: 13306: 13294: 13288: 13287: 13275: 13274: 13267: 13260: 13252: 13243: 13242: 13239: 13238: 13237: 13236: 13233: 13222: 13216: 13210: 13209: 13206: 13205: 13202: 13201: 13199: 13198: 13193: 13188: 13179: 13171: 13154: 13148:Ademetionine ( 13144: 13141: 13140: 13130: 13129: 13126: 13125: 13123: 13122: 13118: 13110: 13100: 13086: 13081: 13050: 13047: 13046: 13034: 13033: 13030: 13029: 13026: 13025: 13023: 13022: 13013: 13011: 13002: 12996: 12995: 12993: 12992: 12987: 12982: 12977: 12972: 12967: 12962: 12953: 12951: 12942: 12936: 12935: 12933: 12932: 12923: 12922: 12913: 12912: 12907: 12902: 12897: 12892: 12887: 12882: 12877: 12872: 12867: 12862: 12857: 12852: 12847: 12842: 12837: 12828: 12826: 12818: 12817: 12805: 12804: 12801: 12800: 12797: 12796: 12794: 12793: 12787: 12785: 12781: 12780: 12778: 12777: 12772: 12767: 12762: 12756: 12754: 12743: 12742: 12740: 12739: 12734: 12729: 12724: 12719: 12714: 12709: 12704: 12699: 12694: 12689: 12684: 12679: 12674: 12669: 12667:Imipraminoxide 12664: 12659: 12654: 12649: 12644: 12639: 12634: 12629: 12624: 12619: 12614: 12609: 12604: 12598: 12596: 12581: 12580: 12564: 12563: 12560: 12559: 12556: 12555: 12553: 12552: 12547: 12542: 12537: 12532: 12527: 12522: 12517: 12512: 12507: 12502: 12497: 12492: 12487: 12482: 12477: 12471: 12469: 12465: 12464: 12462: 12461: 12456: 12450: 12448: 12437: 12436: 12434: 12433: 12428: 12423: 12417: 12415: 12404: 12403: 12401: 12400: 12395: 12390: 12384: 12382: 12371: 12370: 12368: 12367: 12362: 12357: 12351: 12349: 12338: 12337: 12335: 12334: 12329: 12324: 12318: 12316: 12305: 12304: 12302: 12301: 12296: 12291: 12286: 12281: 12276: 12274:Desvenlafaxine 12270: 12268: 12257: 12256: 12254: 12253: 12248: 12243: 12238: 12233: 12228: 12223: 12218: 12212: 12210: 12195: 12194: 12177: 12176: 12164: 12163: 12156: 12149: 12141: 12135: 12134: 12127: 12126:External links 12124: 12121: 12120: 12073: 12007: 11978:(6): 580–587. 11958: 11915: 11888:(4): 790–792. 11872: 11851:(5): 340–347. 11831: 11794:(3): 163–172. 11775: 11740: 11718:10.1.1.486.455 11711:(3): 252–260. 11695: 11688: 11655: 11617: 11610: 11588: 11570: 11547: 11528:(7): 772–792. 11509: 11480:(2): 191–199. 11460: 11442: 11422: 11415: 11395: 11352: 11311: 11276: 11247:(5): 350–357. 11227: 11178: 11157:(1): 148–156. 11134: 11115:(6): 823–830. 11096: 11058: 11009: 10965: 10907: 10864: 10815: 10764: 10749: 10710: 10683:(3): 193–200. 10654: 10627:(1): 554–566. 10610: 10561: 10549: 10542: 10524: 10473: 10452: 10426: 10419: 10411:Academic Press 10405:(2 ed.). 10393: 10350: 10307: 10288:(2): 115–120. 10272: 10245:(3): 277–285. 10224: 10175: 10126: 10097:(4): 122–124. 10077: 10048:(7): 613–624. 10028: 10003: 9972: 9929: 9889: 9882: 9848: 9841: 9823: 9772: 9729: 9688: 9653: 9599: 9548: 9519:(5): 359–366. 9496: 9447: 9412: 9385:(3): 293–297. 9369: 9320: 9303: 9252: 9225: 9182: 9157: 9132: 9097: 9076:(4): 362–369. 9056: 9029: 8980: 8929: 8875: 8848:(4): 571–575. 8832: 8805:(6): 607–614. 8789: 8762:(5): 268–282. 8742: 8709: 8674: 8638: 8589: 8540: 8511: 8494:. 2004-12-01. 8476: 8433: 8414:(5): 713–718. 8397: 8367: 8315: 8284: 8266: 8234: 8213:(8): 865–872. 8193: 8157: 8118: 8100: 8080: 8051:(5): 566–572. 8045:JAMA Neurology 8031: 7988: 7967:(4): 533–540. 7947: 7928:(4): 137–138. 7912: 7854: 7825:(2): 135–141. 7805: 7794:(4): 224–229. 7778: 7751:(5): 211–218. 7732: 7705:(4): 437–447. 7689: 7646: 7625:(4): 281–288. 7605: 7547: 7506: 7479:(5): 345–367. 7463: 7414: 7395:(2): 113–116. 7379: 7336: 7315:(7): 795–803. 7292: 7254: 7247: 7226: 7199:(2): 337–344. 7180: 7161:(3): 413–426. 7145: 7131:. 2023-01-29. 7116: 7059: 7030: 7003:(6): 469–480. 6986: 6955: 6932: 6902: 6867: 6818: 6789:(4): 727–737. 6769: 6720: 6691:(4): 293–310. 6671: 6617: 6576: 6547:(3): 302–303. 6527: 6469: 6428: 6416:Public Citizen 6403: 6392:Public Citizen 6388:"Csoka v. FDA" 6379: 6344: 6306: 6271: 6244:(7): 329–334. 6228: 6201:(2): 180–193. 6185: 6135: 6094: 6030: 6003:(4): 553–561. 5984: 5929: 5844: 5815:(4): 693–712. 5795: 5768:(2): 283–292. 5752: 5731:(5): 171–173. 5711: 5660: 5649:(6): 409–416. 5633: 5599: 5572:(3): 259–266. 5556: 5505: 5465: 5426: 5391: 5380:(9): 406–413. 5364: 5337:(2): 157–164. 5321: 5280: 5236: 5201: 5166: 5139:(2): 192–214. 5123: 5100: 5049: 4998: 4947: 4912: 4855: 4834:(2): 189–207. 4814: 4811:on 2013-05-25. 4789: 4749: 4700: 4656: 4635:(3): 403–415. 4615: 4584: 4553: 4502: 4479: 4430: 4399: 4362:BMC Psychiatry 4347: 4313: 4272: 4228: 4177: 4148: 4099: 4044: 4005: 3986:(4): 348–351. 3970: 3917: 3896:(5): 244–250. 3876: 3847:(6): 572–579. 3827: 3806:(3): 405–412. 3786: 3733: 3679: 3647: 3614: 3577:BMC Psychiatry 3560: 3530:(2): 101–104. 3510: 3458: 3427: 3402: 3395: 3373: 3370:on 2019-02-28. 3333: 3318: 3299: 3298: 3296: 3293: 3292: 3291: 3286: 3281: 3276: 3271: 3266: 3259: 3256: 3247: 3246:Veterinary use 3244: 3235: 3232: 3209: 3206: 3184: 3181: 3174: 3168: 3151: 3144: 3138: 3129: 3110:(Viibryd) and 3079:desvenlafaxine 3062: 3059: 3054: 3053: 3043: 3033: 3023: 3013: 3003: 2993: 2983: 2972: 2971: 2966: 2961: 2960: 2959: 2958: 2948: 2942: 2936: 2931: 2925: 2919: 2913: 2910: 2902: 2899: 2897: 2896:Never marketed 2894: 2889: 2888: 2878: 2867: 2866: 2861: 2856: 2855: 2854: 2853: 2847: 2839: 2836: 2834: 2831: 2826: 2825: 2814: 2813: 2808: 2803: 2802: 2801: 2800: 2792: 2789: 2784: 2783: 2773: 2763: 2753: 2743: 2733: 2722: 2721: 2716: 2711: 2710: 2709: 2708: 2702: 2696: 2690: 2684: 2678: 2670: 2667: 2655: 2646: 2643: 2641: 2638: 2635: 2634: 2631: 2628: 2625: 2622: 2619: 2616: 2613: 2610: 2604: 2603: 2600: 2597: 2594: 2591: 2588: 2585: 2582: 2579: 2573: 2572: 2569: 2566: 2563: 2556: 2553: 2550: 2547: 2544: 2538: 2537: 2534: 2531: 2528: 2521: 2518: 2515: 2512: 2509: 2503: 2502: 2499: 2496: 2493: 2490: 2487: 2484: 2481: 2478: 2472: 2471: 2468: 2465: 2462: 2448: 2445: 2442: 2439: 2436: 2430: 2429: 2426: 2423: 2414: 2409: 2399: 2388: 2378: 2369: 2364: 2353: 2332: 2329: 2290: 2287: 2272: 2269: 2160: 2157: 2148: 2140: 2132: 2128: 2122: 2116: 2111:receptor, and 2108: 2094: 2071: 2070: 2064: 2060: 2059: 2056: 2053: 2050: 2047: 2044: 2038: 2037: 2034: 2031: 2026: 2023: 2020: 2014: 2013: 2010: 2007: 2004: 2001: 1998: 1992: 1991: 1988: 1985: 1982: 1979: 1976: 1970: 1969: 1964: 1959: 1956: 1953: 1950: 1944: 1943: 1940: 1937: 1934: 1931: 1928: 1922: 1921: 1917: 1914: 1910: 1906: 1902: 1898: 1888: 1878: 1875: 1854:downregulation 1816: 1813: 1811: 1808: 1795:Main article: 1792: 1789: 1747: 1744: 1673: 1672: 1669: 1666: 1663: 1660: 1657: 1654: 1648: 1647: 1644: 1641: 1638: 1635: 1632: 1629: 1623: 1622: 1619: 1616: 1613: 1610: 1607: 1604: 1598: 1597: 1594: 1591: 1588: 1585: 1582: 1579: 1573: 1572: 1569: 1566: 1563: 1560: 1557: 1554: 1548: 1547: 1544: 1541: 1538: 1535: 1532: 1529: 1523: 1522: 1517: 1512: 1507: 1502: 1497: 1492: 1472: 1471: 1465: 1459: 1450: 1449: 1447:Methylene blue 1444: 1439: 1434: 1429: 1423: 1417: 1412: 1407: 1402: 1397: 1392: 1387: 1381: 1376: 1371: 1369:methylene blue 1346: 1332: 1329: 1308: 1307:Bipolar switch 1305: 1288: 1285: 1273:Newborn babies 1264: 1261: 1248: 1245: 1224: 1221: 1200: 1197: 1196: 1195: 1188: 1184: 1176: 1172: 1161: 1153: 1150: 1130:United Kingdom 1128:(MHRA) in the 1093: 1090: 1088: 1085: 1045:dilated pupils 1017:Main article: 1014: 1011: 995: 992: 987:bisphosphonate 981: 978: 953:anticoagulants 948: 945: 888: 885: 876: 873: 840: 837: 831:, against the 825:Public Citizen 704: 701: 636:PDE5 inhibitor 607: 604: 592: 589: 580: 577: 551:Main article: 548: 545: 535: 532: 509: 506: 490: 489:Panic disorder 487: 474: 471: 459: 456: 447: 444: 404:social anxiety 399: 396: 392:United Kingdom 379: 378: 375:response rates 363: 359: 355: 311: 308: 284:panic disorder 263: 260: 248:norepinephrine 198:class of drugs 185: 184: 178: 177: 173: 172: 165: 159: 158: 157:External links 154: 153: 150:Best Buy Drugs 146: 140: 139: 132: 126: 125: 121: 120: 115: 109: 108: 103: 97: 96: 87: 83: 82: 79: 73: 72: 68: 67: 61: 53: 52: 44: 43: 26: 9: 6: 4: 3: 2: 17765: 17754: 17751: 17749: 17746: 17744: 17741: 17739: 17736: 17735: 17733: 17720: 17719: 17716: 17710: 17704: 17701: 17699: 17696: 17694: 17691: 17689: 17686: 17684: 17681: 17679: 17676: 17674: 17671: 17669: 17666: 17664: 17661: 17659: 17656: 17654: 17651: 17649: 17646: 17644: 17641: 17639: 17636: 17634: 17631: 17628: 17624: 17621: 17619: 17616: 17614: 17611: 17609: 17606: 17604: 17601: 17599: 17596: 17594: 17591: 17589: 17586: 17584: 17581: 17579: 17576: 17574: 17571: 17569: 17566: 17564: 17561: 17558: 17557: 17554: 17551: 17548: 17547: 17544: 17541: 17539: 17536: 17534: 17531: 17529: 17526: 17524: 17521: 17519: 17516: 17514: 17511: 17509: 17506: 17504: 17501: 17499: 17496: 17494: 17491: 17489: 17486: 17483: 17482: 17479: 17478:Tenocyclidine 17476: 17474: 17471: 17469: 17466: 17464: 17461: 17459: 17456: 17454: 17451: 17449: 17446: 17443: 17442: 17440: 17436: 17430: 17427: 17425: 17422: 17420: 17417: 17412: 17407: 17405: 17402: 17400: 17397: 17395: 17392: 17390: 17387: 17385: 17382: 17380: 17377: 17375: 17372: 17367: 17362: 17357: 17352: 17350: 17347: 17345: 17342: 17340: 17337: 17335: 17332: 17330: 17327: 17325: 17322: 17319: 17318: 17315: 17312: 17310: 17307: 17305: 17302: 17300: 17297: 17295: 17292: 17290: 17287: 17285: 17282: 17280: 17277: 17275: 17272: 17269: 17268: 17265: 17262: 17260: 17257: 17255: 17254:Phencyclidine 17252: 17250: 17247: 17245: 17242: 17240: 17237: 17235: 17232: 17230: 17224: 17222: 17219: 17217: 17214: 17212: 17209: 17207: 17204: 17202: 17199: 17197: 17194: 17192: 17189: 17187: 17184: 17182: 17179: 17177: 17174: 17171: 17170: 17168: 17166: 17159: 17153: 17150: 17148: 17145: 17143: 17140: 17138: 17135: 17133: 17130: 17128: 17125: 17123: 17120: 17118: 17115: 17113: 17110: 17108: 17105: 17103: 17100: 17098: 17095: 17093: 17090: 17088: 17085: 17083: 17080: 17075: 17070: 17065: 17060: 17058: 17052: 17050: 17047: 17045: 17042: 17040: 17037: 17035: 17032: 17030: 17027: 17025: 17024:Amitriptyline 17022: 17020: 17017: 17015: 17012: 17010: 17007: 17005: 17002: 17000: 16997: 16995: 16992: 16990: 16987: 16985: 16982: 16979: 16978: 16975: 16972: 16970: 16967: 16963: 16960: 16957: 16956: 16953: 16950: 16948: 16945: 16943: 16940: 16938: 16935: 16933: 16930: 16928: 16925: 16923: 16920: 16918: 16915: 16913: 16910: 16908: 16905: 16903: 16900: 16898: 16895: 16893: 16890: 16888: 16885: 16883: 16880: 16878: 16875: 16873: 16870: 16868: 16865: 16863: 16860: 16858: 16855: 16853: 16850: 16848: 16845: 16843: 16840: 16838: 16835: 16833: 16830: 16828: 16825: 16822: 16821: 16818: 16815: 16813: 16810: 16808: 16805: 16803: 16800: 16798: 16795: 16793: 16790: 16788: 16785: 16783: 16780: 16778: 16775: 16773: 16770: 16768: 16765: 16763: 16760: 16758: 16755: 16753: 16750: 16748: 16745: 16743: 16740: 16738: 16737:Methoxetamine 16735: 16733: 16730: 16728: 16725: 16723: 16717: 16715: 16712: 16710: 16707: 16705: 16702: 16700: 16697: 16695: 16692: 16690: 16687: 16685: 16682: 16680: 16677: 16675: 16672: 16670: 16667: 16665: 16662: 16660: 16657: 16655: 16652: 16650: 16647: 16645: 16642: 16640: 16637: 16635: 16632: 16629: 16625: 16622: 16619: 16615: 16612: 16610: 16607: 16605: 16602: 16600: 16597: 16595: 16592: 16587: 16582: 16580: 16577: 16575: 16572: 16570: 16567: 16565: 16562: 16560: 16557: 16555: 16552: 16550: 16547: 16545: 16542: 16540: 16537: 16535: 16532: 16530: 16527: 16524: 16523: 16521: 16519: 16512: 16508: 16505: 16498: 16493: 16491: 16486: 16484: 16479: 16478: 16475: 16464: 16463: 16459: 16455: 16454:Serotonergics 16451: 16450:Dopaminergics 16447: 16443: 16439: 16436: 16429: 16423: 16420: 16416: 16413: 16411: 16408: 16407:Agonist-like: 16405: 16402: 16401: 16398: 16395: 16392: 16391: 16389: 16385: 16379: 16376: 16374: 16371: 16369: 16368:Tetrabenazine 16366: 16364: 16361: 16359: 16356: 16354: 16351: 16349: 16346: 16344: 16341: 16339: 16336: 16334: 16331: 16329: 16326: 16324: 16321: 16319: 16316: 16314: 16311: 16309: 16306: 16304: 16301: 16299: 16296: 16294: 16291: 16288: 16284: 16280: 16276: 16273: 16271: 16268: 16267: 16265: 16260: 16254: 16244: 16241: 16238: 16234: 16230: 16226: 16222: 16218: 16214: 16211: 16209: 16206: 16204: 16201: 16199: 16196: 16194: 16191: 16189: 16186: 16184: 16181: 16179: 16176: 16174: 16171: 16169: 16166: 16164: 16161: 16159: 16156: 16153: 16152:phencyclidine 16149: 16148:methoxetamine 16145: 16141: 16137: 16133: 16130: 16127: 16123: 16119: 16116: 16113: 16109: 16105: 16101: 16097: 16093: 16089: 16085: 16082: 16080: 16077: 16075: 16072: 16069: 16068: 16065: 16059: 16058:Protriptyline 16056: 16054: 16051: 16049: 16048:Nortriptyline 16046: 16044: 16041: 16039: 16036: 16034: 16031: 16029: 16026: 16024: 16021: 16019: 16016: 16014: 16011: 16009: 16006: 16004: 16003:Amitriptyline 16001: 15998: 15997: 15994: 15987: 15983: 15980: 15978: 15975: 15973: 15970: 15968: 15967:Tedatioxetine 15965: 15963: 15960: 15958: 15955: 15953: 15950: 15948: 15945: 15943: 15940: 15938: 15935: 15933: 15930: 15928: 15925: 15923: 15920: 15918: 15915: 15913: 15910: 15908: 15905: 15903: 15900: 15898: 15895: 15893: 15890: 15888: 15885: 15883: 15880: 15878: 15875: 15873: 15870: 15868: 15865: 15863: 15860: 15858: 15855: 15853: 15850: 15848: 15845: 15843: 15840: 15838: 15835: 15833: 15830: 15828: 15827:Centanafadine 15825: 15823: 15820: 15818: 15815: 15813: 15810: 15808: 15805: 15803: 15800: 15797: 15796: 15793: 15787: 15784: 15782: 15779: 15777: 15774: 15772: 15771:N-Methyl-PPPA 15769: 15767: 15764: 15762: 15759: 15757: 15754: 15752: 15749: 15747: 15744: 15742: 15739: 15737: 15734: 15732: 15729: 15727: 15724: 15721: 15720: 15717: 15711: 15708: 15706: 15703: 15701: 15698: 15696: 15693: 15691: 15688: 15686: 15683: 15681: 15678: 15676: 15673: 15671: 15668: 15666: 15663: 15660: 15659: 15656: 15653: 15651: 15648: 15646: 15643: 15641: 15638: 15636: 15633: 15631: 15628: 15626: 15623: 15621: 15618: 15616: 15613: 15611: 15610:Norfluoxetine 15608: 15606: 15603: 15601: 15598: 15596: 15593: 15591: 15588: 15586: 15583: 15581: 15578: 15576: 15573: 15571: 15568: 15566: 15563: 15561: 15558: 15556: 15553: 15551: 15550:Centpropazine 15548: 15546: 15543: 15541: 15538: 15535: 15534: 15531: 15528: 15521: 15510: 15504: 15493: 15489: 15485: 15481: 15477: 15473: 15472:desmetramadol 15469: 15466: 15464: 15461: 15459: 15456: 15454: 15453: 15452:Ginkgo biloba 15449: 15447: 15444: 15442: 15439: 15436: 15435:phencyclidine 15432: 15428: 15425: 15422: 15418: 15414: 15411: 15408: 15404: 15400: 15396: 15392: 15389: 15386: 15385: 15382: 15376: 15373: 15371: 15368: 15366: 15363: 15361: 15358: 15356: 15353: 15350: 15349: 15346: 15340: 15337: 15335: 15334:Protriptyline 15332: 15330: 15329:Nortriptyline 15327: 15325: 15322: 15320: 15317: 15315: 15312: 15310: 15307: 15305: 15302: 15300: 15297: 15295: 15292: 15290: 15287: 15285: 15282: 15280: 15279:Amitriptyline 15277: 15274: 15273: 15270: 15263: 15259: 15256: 15254: 15251: 15249: 15246: 15244: 15243:Tedatioxetine 15241: 15239: 15236: 15234: 15231: 15229: 15226: 15224: 15221: 15219: 15216: 15214: 15211: 15209: 15206: 15204: 15201: 15199: 15196: 15194: 15191: 15189: 15186: 15184: 15181: 15179: 15176: 15174: 15171: 15169: 15166: 15164: 15161: 15159: 15156: 15154: 15151: 15149: 15146: 15144: 15141: 15139: 15136: 15134: 15131: 15129: 15126: 15124: 15121: 15119: 15116: 15114: 15111: 15109: 15106: 15104: 15103:Centanafadine 15101: 15099: 15096: 15094: 15091: 15089: 15086: 15084: 15081: 15079: 15076: 15073: 15072: 15069: 15063: 15060: 15058: 15055: 15053: 15050: 15048: 15045: 15043: 15042:N-Methyl-PPPA 15040: 15038: 15035: 15033: 15030: 15028: 15025: 15023: 15020: 15018: 15015: 15013: 15010: 15008: 15005: 15003: 15000: 14997: 14996: 14993: 14987: 14984: 14982: 14979: 14977: 14974: 14972: 14969: 14967: 14964: 14962: 14959: 14957: 14954: 14952: 14949: 14947: 14944: 14942: 14939: 14937: 14934: 14932: 14929: 14927: 14924: 14922: 14919: 14917: 14914: 14911: 14910: 14907: 14901: 14898: 14896: 14893: 14891: 14888: 14886: 14883: 14881: 14878: 14876: 14873: 14871: 14868: 14866: 14863: 14861: 14858: 14856: 14853: 14851: 14848: 14846: 14843: 14841: 14838: 14836: 14833: 14831: 14828: 14825: 14824: 14821: 14818: 14811: 14800: 14794: 14784: 14781: 14779: 14776: 14774: 14771: 14769: 14768:Tedatioxetine 14766: 14764: 14761: 14759: 14756: 14754: 14751: 14749: 14746: 14744: 14741: 14739: 14736: 14734: 14731: 14729: 14726: 14724: 14721: 14719: 14716: 14714: 14711: 14709: 14706: 14704: 14701: 14699: 14696: 14694: 14691: 14689: 14686: 14684: 14681: 14679: 14676: 14674: 14671: 14669: 14666: 14664: 14661: 14659: 14656: 14654: 14651: 14649: 14646: 14644: 14641: 14639: 14636: 14634: 14631: 14629: 14626: 14624: 14621: 14619: 14616: 14614: 14611: 14609: 14606: 14604: 14601: 14599: 14596: 14594: 14591: 14589: 14586: 14584: 14581: 14579: 14576: 14574: 14571: 14569: 14566: 14564: 14561: 14559: 14556: 14554: 14551: 14549: 14546: 14544: 14541: 14539: 14536: 14534: 14533: 14529: 14527: 14524: 14522: 14519: 14517: 14514: 14512: 14509: 14507: 14504: 14502: 14499: 14497: 14494: 14492: 14489: 14487: 14484: 14481: 14480: 14477: 14471: 14468: 14466: 14463: 14461: 14458: 14456: 14453: 14451: 14448: 14446: 14443: 14441: 14438: 14436: 14433: 14431: 14428: 14426: 14423: 14421: 14418: 14416: 14413: 14411: 14408: 14406: 14403: 14401: 14398: 14396: 14393: 14391: 14390:Ioflupane (I) 14388: 14386: 14383: 14381: 14378: 14376: 14373: 14371: 14368: 14366: 14363: 14361: 14358: 14356: 14353: 14351: 14348: 14346: 14343: 14341: 14338: 14335: 14334: 14331: 14325: 14322: 14320: 14317: 14315: 14312: 14310: 14307: 14305: 14302: 14301:Pyrrolidines: 14299: 14298: 14295: 14289: 14288:Tenocyclidine 14286: 14284: 14281: 14279: 14276: 14274: 14273:Phencyclidine 14271: 14269: 14266: 14264: 14261: 14259: 14256: 14254: 14251: 14249: 14246: 14244: 14241: 14239: 14236: 14234: 14231: 14229: 14226: 14223: 14222: 14219: 14213: 14210: 14208: 14205: 14203: 14200: 14198: 14195: 14193: 14190: 14188: 14185: 14183: 14180: 14178: 14175: 14172: 14171: 14168: 14165: 14158: 14147: 14141: 14137: 14130: 14125: 14123: 14118: 14116: 14111: 14110: 14107: 14094: 14090: 14086: 14082: 14078: 14075: 14072: 14068: 14065: 14064: 14062: 14058: 14051: 14044: 14039: 14036: 14029: 14024: 14021: 14017: 14013: 14009: 14005: 14001: 13994: 13989: 13988: 13986: 13984: 13980: 13976: 13966: 13961: 13959: 13954: 13952: 13947: 13946: 13943: 13927: 13925: 13922: 13921: 13919: 13916: 13913: 13910: 13908: 13905: 13904: 13900: 13894: 13891: 13889: 13886: 13884: 13881: 13879: 13876: 13874: 13871: 13869: 13866: 13864: 13863:Phenaglycodol 13861: 13859: 13856: 13854: 13851: 13849: 13846: 13844: 13841: 13839: 13836: 13834: 13831: 13829: 13826: 13824: 13821: 13819: 13816: 13814: 13811: 13810: 13808: 13804: 13797: 13793: 13792:Beta blockers 13790: 13787: 13783: 13779: 13775: 13772: 13769: 13765: 13762: 13761: 13759: 13755: 13749: 13745: 13739: 13736: 13734: 13731: 13730: 13728: 13726: 13722: 13716: 13713: 13711: 13708: 13706: 13703: 13701: 13698: 13696: 13693: 13689: 13682: 13677: 13674: 13667: 13662: 13659: 13652: 13647: 13644: 13637: 13632: 13629: 13622: 13617: 13614: 13607: 13602: 13601: 13599: 13597: 13593: 13587: 13584: 13582: 13579: 13577: 13574: 13572: 13569: 13568: 13566: 13562: 13559: 13544: 13540: 13534: 13531: 13530: 13528: 13526: 13522: 13516: 13513: 13511: 13508: 13506: 13505:Chlormezanone 13503: 13501: 13498: 13495: 13491: 13488: 13485: 13484:phenobarbital 13481: 13478: 13476: 13473: 13469: 13466: 13464: 13461: 13459: 13456: 13454: 13451: 13449: 13446: 13444: 13441: 13439: 13436: 13434: 13431: 13429: 13426: 13424: 13421: 13419: 13416: 13414: 13411: 13409: 13406: 13404: 13401: 13399: 13396: 13394: 13391: 13389: 13386: 13384: 13381: 13379: 13376: 13374: 13371: 13369: 13366: 13364: 13361: 13359: 13355: 13354: 13352: 13347: 13339: 13329: 13323: 13320: 13318: 13315: 13313: 13310: 13309: 13307: 13305: 13299: 13289: 13284: 13280: 13273: 13268: 13266: 13261: 13259: 13254: 13253: 13250: 13234: 13232: 13229: 13228: 13226: 13223: 13220: 13217: 13215: 13212: 13211: 13207: 13197: 13194: 13192: 13189: 13187: 13180: 13178: 13176: 13172: 13169: 13165: 13161: 13160:neurosteroids 13158: 13155: 13153: 13146: 13145: 13142: 13138:Miscellaneous 13135: 13131: 13116: 13115:levothyroxine 13108: 13104: 13101: 13098: 13094: 13090: 13087: 13085: 13082: 13079: 13075: 13071: 13067: 13063: 13062:brexpiprazole 13059: 13055: 13052: 13051: 13048: 13044: 13039: 13035: 13021: 13018: 13017:Irreversible: 13015: 13014: 13012: 13006: 12997: 12991: 12988: 12986: 12983: 12981: 12978: 12976: 12973: 12971: 12968: 12966: 12963: 12961: 12958: 12955: 12954: 12952: 12946: 12937: 12931: 12928: 12925: 12924: 12921: 12918: 12915: 12914: 12911: 12908: 12906: 12903: 12901: 12898: 12896: 12893: 12891: 12888: 12886: 12883: 12881: 12878: 12876: 12873: 12871: 12868: 12866: 12863: 12861: 12858: 12856: 12853: 12851: 12850:Isocarboxazid 12848: 12846: 12843: 12841: 12838: 12836: 12833: 12832:Irreversible: 12830: 12829: 12827: 12825:Non-selective 12823: 12819: 12815: 12810: 12806: 12792: 12789: 12788: 12786: 12782: 12776: 12773: 12771: 12768: 12766: 12763: 12761: 12758: 12757: 12755: 12750: 12744: 12738: 12735: 12733: 12730: 12728: 12725: 12723: 12722:Protriptyline 12720: 12718: 12715: 12713: 12710: 12708: 12705: 12703: 12700: 12698: 12697:Nortriptyline 12695: 12693: 12692:Nitroxazepine 12690: 12688: 12685: 12683: 12680: 12678: 12675: 12673: 12670: 12668: 12665: 12663: 12660: 12658: 12655: 12653: 12650: 12648: 12645: 12643: 12640: 12638: 12635: 12633: 12632:Demexiptiline 12630: 12628: 12625: 12623: 12620: 12618: 12615: 12613: 12610: 12608: 12607:Amitriptyline 12605: 12603: 12600: 12599: 12597: 12592: 12586: 12582: 12578: 12574: 12569: 12565: 12551: 12548: 12546: 12543: 12541: 12538: 12536: 12533: 12531: 12528: 12526: 12523: 12521: 12518: 12516: 12513: 12511: 12508: 12506: 12503: 12501: 12498: 12496: 12493: 12491: 12488: 12486: 12483: 12481: 12478: 12476: 12473: 12472: 12470: 12466: 12460: 12457: 12455: 12452: 12451: 12449: 12444: 12438: 12432: 12429: 12427: 12424: 12422: 12419: 12418: 12416: 12411: 12405: 12399: 12396: 12394: 12391: 12389: 12386: 12385: 12383: 12378: 12372: 12366: 12363: 12361: 12358: 12356: 12353: 12352: 12350: 12345: 12339: 12333: 12330: 12328: 12325: 12323: 12320: 12319: 12317: 12312: 12306: 12300: 12297: 12295: 12292: 12290: 12287: 12285: 12282: 12280: 12277: 12275: 12272: 12271: 12269: 12264: 12258: 12252: 12249: 12247: 12244: 12242: 12239: 12237: 12234: 12232: 12229: 12227: 12224: 12222: 12219: 12217: 12214: 12213: 12211: 12206: 12200: 12196: 12192: 12188: 12182: 12178: 12173: 12169: 12162: 12157: 12155: 12150: 12148: 12143: 12142: 12139: 12133: 12130: 12129: 12116: 12112: 12108: 12104: 12100: 12096: 12092: 12088: 12084: 12077: 12069: 12065: 12061: 12057: 12052: 12047: 12043: 12039: 12035: 12031: 12027: 12023: 12019: 12011: 12003: 11999: 11994: 11989: 11985: 11981: 11977: 11973: 11969: 11962: 11954: 11950: 11946: 11942: 11938: 11934: 11930: 11926: 11919: 11911: 11907: 11903: 11899: 11895: 11891: 11887: 11883: 11876: 11868: 11864: 11859: 11854: 11850: 11846: 11842: 11835: 11827: 11823: 11819: 11815: 11811: 11807: 11802: 11797: 11793: 11789: 11785: 11779: 11771: 11767: 11763: 11759: 11755: 11751: 11744: 11736: 11732: 11728: 11724: 11719: 11714: 11710: 11706: 11699: 11691: 11689:1-57059-649-2 11685: 11681: 11677: 11673: 11669: 11662: 11660: 11651: 11647: 11643: 11639: 11635: 11631: 11624: 11622: 11613: 11607: 11603: 11602: 11595: 11593: 11577: 11573: 11567: 11563: 11562: 11554: 11552: 11543: 11539: 11535: 11531: 11527: 11523: 11516: 11514: 11505: 11501: 11496: 11491: 11487: 11483: 11479: 11475: 11471: 11464: 11449: 11445: 11439: 11435: 11434: 11426: 11418: 11412: 11408: 11407: 11399: 11391: 11387: 11383: 11379: 11375: 11371: 11367: 11363: 11362:CNS Spectrums 11356: 11341: 11337: 11333: 11329: 11322: 11320: 11318: 11316: 11307: 11303: 11299: 11295: 11291: 11287: 11280: 11272: 11268: 11264: 11260: 11255: 11250: 11246: 11242: 11238: 11231: 11223: 11219: 11214: 11209: 11205: 11201: 11197: 11193: 11189: 11182: 11174: 11170: 11165: 11160: 11156: 11152: 11148: 11141: 11139: 11130: 11126: 11122: 11118: 11114: 11110: 11109:Immunobiology 11103: 11101: 11092: 11088: 11084: 11080: 11076: 11072: 11065: 11063: 11054: 11050: 11045: 11040: 11036: 11032: 11028: 11024: 11020: 11013: 11005: 11001: 10997: 10993: 10989: 10985: 10981: 10977: 10969: 10954: 10950: 10946: 10942: 10938: 10934: 10930: 10926: 10922: 10918: 10911: 10903: 10899: 10895: 10891: 10887: 10883: 10879: 10875: 10868: 10860: 10856: 10851: 10846: 10842: 10838: 10834: 10830: 10826: 10819: 10811: 10807: 10802: 10797: 10792: 10787: 10783: 10779: 10775: 10768: 10760: 10756: 10752: 10746: 10742: 10738: 10734: 10727: 10725: 10723: 10721: 10719: 10717: 10715: 10706: 10702: 10698: 10694: 10690: 10686: 10682: 10678: 10671: 10669: 10667: 10665: 10663: 10661: 10659: 10650: 10646: 10642: 10638: 10634: 10630: 10626: 10622: 10614: 10606: 10602: 10597: 10592: 10588: 10584: 10580: 10576: 10572: 10565: 10556: 10554: 10545: 10539: 10535: 10528: 10520: 10516: 10511: 10506: 10501: 10496: 10492: 10488: 10484: 10477: 10459: 10455: 10449: 10442: 10441: 10433: 10431: 10422: 10416: 10412: 10408: 10404: 10397: 10389: 10385: 10381: 10377: 10373: 10369: 10366:(2): 94–104. 10365: 10361: 10354: 10346: 10342: 10338: 10334: 10330: 10326: 10322: 10318: 10311: 10303: 10299: 10295: 10291: 10287: 10283: 10276: 10268: 10264: 10260: 10256: 10252: 10248: 10244: 10240: 10233: 10231: 10229: 10220: 10216: 10211: 10206: 10202: 10198: 10194: 10190: 10186: 10179: 10171: 10167: 10162: 10157: 10153: 10149: 10145: 10141: 10137: 10130: 10122: 10118: 10113: 10108: 10104: 10100: 10096: 10092: 10088: 10081: 10073: 10069: 10064: 10059: 10055: 10051: 10047: 10043: 10039: 10032: 10017: 10013: 10007: 9999: 9995: 9991: 9987: 9983: 9976: 9968: 9964: 9960: 9956: 9952: 9948: 9944: 9940: 9933: 9925: 9921: 9917: 9913: 9909: 9905: 9898: 9896: 9894: 9885: 9879: 9875: 9871: 9867: 9862: 9861: 9852: 9844: 9838: 9834: 9827: 9819: 9815: 9810: 9805: 9800: 9795: 9791: 9787: 9783: 9776: 9768: 9764: 9760: 9756: 9752: 9748: 9744: 9740: 9733: 9725: 9721: 9716: 9711: 9707: 9703: 9702:Pain Medicine 9699: 9692: 9684: 9680: 9676: 9672: 9668: 9664: 9657: 9649: 9645: 9641: 9637: 9632: 9627: 9623: 9619: 9615: 9611: 9603: 9595: 9591: 9586: 9581: 9576: 9571: 9567: 9563: 9559: 9552: 9544: 9540: 9535: 9530: 9526: 9522: 9518: 9514: 9510: 9503: 9501: 9492: 9488: 9484: 9480: 9475: 9470: 9466: 9462: 9458: 9451: 9443: 9439: 9435: 9431: 9427: 9423: 9416: 9408: 9404: 9400: 9396: 9392: 9388: 9384: 9380: 9373: 9365: 9361: 9356: 9351: 9347: 9343: 9339: 9335: 9331: 9324: 9318: 9314: 9313: 9307: 9299: 9295: 9290: 9285: 9280: 9275: 9272:: 1257–1266. 9271: 9267: 9263: 9256: 9248: 9244: 9240: 9236: 9229: 9221: 9217: 9213: 9209: 9205: 9201: 9197: 9193: 9186: 9172:on 2010-09-23 9171: 9167: 9161: 9146: 9142: 9136: 9128: 9124: 9120: 9116: 9112: 9108: 9101: 9093: 9089: 9084: 9079: 9075: 9071: 9067: 9060: 9052: 9048: 9044: 9040: 9033: 9025: 9021: 9016: 9011: 9007: 9003: 8999: 8995: 8991: 8984: 8976: 8972: 8967: 8962: 8957: 8952: 8948: 8944: 8940: 8933: 8925: 8921: 8916: 8911: 8906: 8901: 8897: 8893: 8889: 8882: 8880: 8871: 8867: 8863: 8859: 8855: 8851: 8847: 8843: 8836: 8828: 8824: 8820: 8816: 8812: 8808: 8804: 8800: 8793: 8785: 8781: 8777: 8773: 8769: 8765: 8761: 8757: 8749: 8747: 8737: 8732: 8728: 8724: 8720: 8713: 8705: 8701: 8697: 8693: 8689: 8685: 8678: 8670: 8666: 8662: 8658: 8655:(1–3): 3–13. 8654: 8650: 8642: 8634: 8630: 8625: 8620: 8616: 8612: 8609:(7488): 396. 8608: 8604: 8600: 8593: 8585: 8581: 8576: 8571: 8567: 8563: 8560:(7488): 385. 8559: 8555: 8551: 8544: 8530:on 2008-08-02 8529: 8525: 8521: 8515: 8497: 8493: 8486: 8480: 8472: 8468: 8464: 8460: 8456: 8452: 8448: 8444: 8437: 8429: 8425: 8421: 8417: 8413: 8409: 8401: 8385: 8381: 8377: 8371: 8363: 8359: 8354: 8349: 8345: 8341: 8337: 8333: 8329: 8322: 8320: 8304: 8300: 8299: 8294: 8288: 8280: 8276: 8270: 8252: 8245: 8238: 8230: 8226: 8221: 8216: 8212: 8208: 8204: 8197: 8179: 8175: 8168: 8161: 8143: 8139: 8132: 8125: 8123: 8107: 8103: 8097: 8093: 8092: 8084: 8076: 8072: 8067: 8062: 8058: 8054: 8050: 8046: 8042: 8035: 8027: 8023: 8019: 8015: 8011: 8007: 8003: 7999: 7992: 7984: 7980: 7975: 7970: 7966: 7962: 7958: 7951: 7943: 7939: 7935: 7931: 7927: 7923: 7916: 7901: 7897: 7893: 7889: 7885: 7881: 7877: 7873: 7869: 7865: 7858: 7850: 7846: 7841: 7836: 7832: 7828: 7824: 7820: 7816: 7809: 7801: 7797: 7793: 7789: 7782: 7774: 7770: 7766: 7762: 7758: 7754: 7750: 7746: 7739: 7737: 7728: 7724: 7720: 7716: 7712: 7708: 7704: 7700: 7693: 7685: 7681: 7677: 7673: 7669: 7665: 7661: 7657: 7650: 7642: 7638: 7633: 7628: 7624: 7620: 7616: 7609: 7594: 7590: 7586: 7582: 7578: 7574: 7570: 7566: 7562: 7558: 7551: 7543: 7539: 7534: 7529: 7525: 7521: 7517: 7510: 7502: 7498: 7494: 7490: 7486: 7482: 7478: 7474: 7467: 7459: 7455: 7450: 7445: 7441: 7437: 7433: 7429: 7425: 7418: 7410: 7406: 7402: 7398: 7394: 7390: 7383: 7375: 7371: 7367: 7363: 7359: 7355: 7351: 7347: 7340: 7332: 7328: 7323: 7318: 7314: 7310: 7306: 7299: 7297: 7288: 7284: 7280: 7276: 7272: 7268: 7261: 7259: 7250: 7244: 7240: 7233: 7231: 7222: 7218: 7214: 7210: 7206: 7202: 7198: 7194: 7187: 7185: 7176: 7172: 7168: 7164: 7160: 7156: 7149: 7134: 7130: 7126: 7120: 7112: 7108: 7103: 7098: 7094: 7090: 7086: 7082: 7078: 7074: 7070: 7063: 7048: 7044: 7040: 7034: 7026: 7022: 7018: 7014: 7010: 7006: 7002: 6998: 6990: 6972: 6965: 6959: 6952: 6948: 6944: 6941: 6936: 6921: 6917: 6913: 6906: 6898: 6894: 6890: 6886: 6882: 6878: 6871: 6863: 6859: 6854: 6849: 6845: 6841: 6837: 6833: 6829: 6822: 6814: 6810: 6805: 6800: 6796: 6792: 6788: 6784: 6780: 6773: 6765: 6761: 6756: 6751: 6747: 6743: 6739: 6735: 6731: 6724: 6716: 6712: 6707: 6702: 6698: 6694: 6690: 6686: 6682: 6675: 6667: 6663: 6659: 6655: 6650: 6649:11365/1137950 6645: 6641: 6637: 6633: 6629: 6621: 6613: 6609: 6604: 6599: 6595: 6591: 6587: 6580: 6572: 6568: 6563: 6558: 6554: 6550: 6546: 6542: 6538: 6531: 6523: 6519: 6514: 6509: 6504: 6499: 6495: 6491: 6487: 6480: 6478: 6476: 6474: 6465: 6461: 6456: 6451: 6447: 6443: 6439: 6432: 6417: 6413: 6407: 6393: 6389: 6383: 6375: 6371: 6367: 6363: 6359: 6355: 6348: 6329: 6325: 6318: 6317: 6310: 6302: 6298: 6294: 6290: 6286: 6282: 6275: 6267: 6263: 6259: 6255: 6251: 6247: 6243: 6239: 6232: 6224: 6220: 6216: 6212: 6208: 6204: 6200: 6196: 6189: 6181: 6177: 6173: 6169: 6165: 6161: 6157: 6153: 6146: 6144: 6142: 6140: 6132: 6128: 6124: 6120: 6116: 6112: 6108: 6101: 6099: 6080: 6076: 6072: 6068: 6064: 6060: 6056: 6052: 6048: 6041: 6034: 6026: 6022: 6018: 6014: 6010: 6006: 6002: 5998: 5991: 5989: 5980: 5976: 5971: 5966: 5962: 5958: 5954: 5950: 5946: 5938: 5936: 5934: 5918: 5914: 5910: 5906: 5902: 5897: 5892: 5888: 5884: 5880: 5876: 5872: 5865: 5863: 5861: 5859: 5857: 5855: 5853: 5851: 5849: 5840: 5836: 5831: 5826: 5822: 5818: 5814: 5810: 5806: 5799: 5791: 5787: 5783: 5779: 5775: 5771: 5767: 5763: 5756: 5748: 5744: 5739: 5734: 5730: 5726: 5722: 5715: 5707: 5703: 5698: 5693: 5688: 5683: 5679: 5675: 5671: 5664: 5656: 5652: 5648: 5644: 5637: 5623:on 2020-06-04 5622: 5618: 5614: 5610: 5603: 5595: 5591: 5587: 5583: 5579: 5575: 5571: 5567: 5560: 5552: 5548: 5543: 5538: 5533: 5528: 5524: 5520: 5516: 5509: 5502: 5497: 5493: 5489: 5485: 5481: 5477: 5469: 5453: 5449: 5445: 5441: 5437: 5430: 5422: 5418: 5414: 5410: 5406: 5402: 5395: 5387: 5383: 5379: 5375: 5368: 5360: 5356: 5352: 5348: 5344: 5340: 5336: 5332: 5325: 5317: 5313: 5308: 5303: 5299: 5295: 5291: 5284: 5269: 5264: 5259: 5255: 5251: 5247: 5240: 5232: 5228: 5224: 5220: 5216: 5212: 5205: 5197: 5193: 5189: 5185: 5181: 5177: 5170: 5162: 5158: 5154: 5150: 5146: 5142: 5138: 5134: 5127: 5119: 5115: 5111: 5110:CNS Spectrums 5104: 5096: 5092: 5087: 5082: 5077: 5072: 5068: 5064: 5060: 5053: 5045: 5041: 5036: 5031: 5026: 5021: 5017: 5013: 5009: 5002: 4994: 4990: 4985: 4980: 4975: 4970: 4966: 4962: 4958: 4951: 4943: 4939: 4935: 4931: 4927: 4923: 4916: 4908: 4904: 4899: 4894: 4890: 4886: 4882: 4878: 4874: 4870: 4866: 4859: 4851: 4847: 4842: 4837: 4833: 4829: 4825: 4818: 4810: 4806: 4802: 4796: 4794: 4775: 4771: 4764: 4758: 4756: 4754: 4745: 4741: 4736: 4731: 4727: 4723: 4719: 4715: 4711: 4704: 4696: 4692: 4688: 4684: 4680: 4676: 4672: 4668: 4660: 4652: 4648: 4643: 4638: 4634: 4630: 4626: 4619: 4601: 4594: 4588: 4570: 4563: 4557: 4549: 4545: 4540: 4535: 4530: 4525: 4521: 4517: 4513: 4506: 4498: 4494: 4490: 4483: 4475: 4471: 4466: 4461: 4457: 4453: 4449: 4445: 4441: 4434: 4420:on 2008-12-06 4416: 4409: 4403: 4395: 4391: 4386: 4381: 4376: 4371: 4367: 4363: 4359: 4351: 4337:on 2012-10-21 4333: 4326: 4320: 4318: 4309: 4305: 4300: 4295: 4291: 4287: 4283: 4276: 4268: 4264: 4260: 4256: 4252: 4248: 4245:(1): 102–11. 4244: 4240: 4232: 4224: 4220: 4215: 4210: 4205: 4200: 4196: 4192: 4188: 4181: 4166: 4162: 4158: 4152: 4144: 4140: 4135: 4130: 4126: 4122: 4118: 4114: 4110: 4103: 4096: 4091: 4087: 4082: 4077: 4072: 4067: 4063: 4059: 4055: 4048: 4041: 4036: 4032: 4028: 4024: 4020: 4016: 4009: 4001: 3997: 3993: 3989: 3985: 3981: 3974: 3966: 3962: 3957: 3952: 3948: 3944: 3940: 3936: 3932: 3924: 3922: 3913: 3909: 3904: 3899: 3895: 3891: 3887: 3880: 3872: 3868: 3863: 3858: 3854: 3850: 3846: 3842: 3838: 3831: 3823: 3819: 3814: 3809: 3805: 3801: 3797: 3790: 3782: 3778: 3774: 3770: 3765: 3760: 3756: 3752: 3748: 3744: 3737: 3729: 3725: 3720: 3715: 3710: 3705: 3701: 3697: 3696:PLOS Medicine 3693: 3686: 3684: 3672: 3668: 3661: 3654: 3652: 3642: 3637: 3634:(2): 92–100. 3633: 3629: 3625: 3618: 3610: 3606: 3601: 3596: 3591: 3586: 3582: 3578: 3574: 3567: 3565: 3549: 3545: 3541: 3537: 3533: 3529: 3525: 3521: 3514: 3506: 3502: 3497: 3492: 3488: 3484: 3480: 3476: 3472: 3465: 3463: 3446: 3442: 3438: 3431: 3417: 3413: 3406: 3398: 3392: 3388: 3384: 3377: 3366: 3362: 3358: 3354: 3350: 3343: 3337: 3329: 3325: 3321: 3315: 3311: 3304: 3300: 3290: 3287: 3285: 3282: 3280: 3277: 3275: 3272: 3270: 3267: 3265: 3262: 3261: 3255: 3253: 3243: 3241: 3231: 3228: 3224: 3219: 3215: 3205: 3203: 3199: 3195: 3190: 3180: 3178: 3166: 3162: 3158: 3155: 3147: 3136: 3133: 3125: 3121: 3117: 3113: 3109: 3105: 3103: 3099: 3096: 3092: 3088: 3084: 3080: 3076: 3072: 3068: 3061:Related drugs 3052: 3048: 3044: 3042: 3038: 3034: 3032: 3028: 3024: 3022: 3018: 3014: 3012: 3008: 3004: 3002: 2998: 2994: 2992: 2988: 2984: 2982: 2978: 2974: 2973: 2969: 2956: 2952: 2949: 2946: 2943: 2940: 2937: 2935: 2932: 2929: 2926: 2923: 2920: 2917: 2914: 2912:Centpropazine 2911: 2908: 2905: 2904: 2887: 2883: 2879: 2877: 2873: 2869: 2868: 2864: 2851: 2848: 2845: 2842: 2841: 2824: 2820: 2816: 2815: 2811: 2798: 2795: 2794: 2782: 2778: 2774: 2772: 2768: 2764: 2762: 2758: 2754: 2752: 2748: 2744: 2742: 2738: 2734: 2732: 2728: 2724: 2723: 2719: 2706: 2703: 2700: 2697: 2694: 2691: 2688: 2685: 2682: 2679: 2676: 2673: 2672: 2662: 2651: 2640:List of SSRIs 2632: 2629: 2626: 2623: 2620: 2617: 2614: 2611: 2609: 2606: 2605: 2601: 2598: 2595: 2592: 2589: 2586: 2583: 2580: 2578: 2575: 2574: 2570: 2567: 2564: 2561: 2557: 2554: 2551: 2548: 2545: 2543: 2540: 2539: 2535: 2532: 2529: 2526: 2522: 2519: 2516: 2513: 2510: 2508: 2505: 2504: 2500: 2497: 2494: 2491: 2488: 2485: 2482: 2479: 2477: 2474: 2473: 2469: 2466: 2463: 2460: 2456: 2452: 2449: 2446: 2443: 2440: 2437: 2435: 2432: 2431: 2427: 2424: 2418: 2410: 2407: 2404: 2400: 2394: 2389: 2384: 2379: 2373: 2365: 2359: 2354: 2351: 2350: 2346: 2340: 2338: 2328: 2326: 2322: 2317: 2315: 2311: 2307: 2303: 2298: 2296: 2286: 2284: 2278: 2268: 2266: 2262: 2258: 2254: 2249: 2247: 2243: 2239: 2235: 2231: 2225: 2222: 2218: 2214: 2210: 2206: 2202: 2197: 2195: 2189: 2187: 2183: 2179: 2175: 2171: 2167: 2156: 2154: 2146: 2138: 2126: 2114: 2106: 2102: 2098: 2090: 2086: 2082: 2078: 2061: 2057: 2054: 2051: 2048: 2045: 2043: 2040: 2039: 2035: 2032: 2027: 2024: 2021: 2019: 2016: 2015: 2011: 2008: 2005: 2002: 1999: 1997: 1994: 1993: 1989: 1986: 1983: 1980: 1977: 1975: 1972: 1971: 1965: 1960: 1957: 1954: 1951: 1949: 1946: 1945: 1941: 1938: 1935: 1932: 1929: 1927: 1924: 1923: 1915: 1913: 1907: 1905: 1894: 1889: 1886: 1885: 1874: 1871: 1865: 1863: 1859: 1855: 1849: 1847: 1843: 1838: 1834: 1830: 1826: 1822: 1807: 1805: 1798: 1788: 1785: 1783: 1779: 1775: 1771: 1767: 1762: 1759: 1753: 1743: 1739: 1737: 1733: 1729: 1725: 1721: 1717: 1713: 1709: 1705: 1701: 1700:hydromorphone 1697: 1693: 1688: 1679: 1670: 1667: 1664: 1661: 1658: 1655: 1653: 1650: 1649: 1645: 1642: 1639: 1636: 1633: 1630: 1628: 1625: 1624: 1620: 1617: 1614: 1611: 1608: 1605: 1603: 1600: 1599: 1595: 1592: 1589: 1586: 1583: 1580: 1578: 1575: 1574: 1570: 1567: 1564: 1561: 1558: 1555: 1553: 1550: 1549: 1545: 1542: 1539: 1536: 1533: 1530: 1528: 1525: 1524: 1521: 1518: 1516: 1513: 1511: 1508: 1506: 1503: 1501: 1498: 1496: 1493: 1490: 1489: 1483: 1481: 1478: 1469: 1466: 1463: 1460: 1458: 1455: 1454: 1453: 1448: 1445: 1443: 1440: 1438: 1435: 1433: 1430: 1427: 1424: 1421: 1418: 1416: 1413: 1411: 1408: 1406: 1403: 1401: 1398: 1396: 1393: 1391: 1388: 1385: 1382: 1380: 1377: 1375: 1372: 1370: 1366: 1362: 1358: 1354: 1350: 1347: 1345: 1342: 1341: 1340: 1338: 1328: 1326: 1322: 1318: 1314: 1304: 1302: 1298: 1294: 1284: 1282: 1278: 1277:blood vessels 1274: 1270: 1260: 1258: 1254: 1244: 1240: 1236: 1234: 1233:preterm birth 1229: 1220: 1218: 1214: 1210: 1209:risk of death 1206: 1205:meta-analysis 1199:Risk of death 1193: 1189: 1185: 1181: 1177: 1173: 1170: 1166: 1162: 1159: 1158: 1157: 1149: 1147: 1143: 1140:(Zoloft) and 1139: 1135: 1131: 1127: 1124:In 2004, the 1122: 1120: 1119:correlational 1114: 1111: 1107: 1103: 1099: 1084: 1082: 1078: 1074: 1070: 1066: 1062: 1058: 1054: 1053:hyperreflexia 1050: 1046: 1042: 1039:, shivering, 1038: 1034: 1030: 1026: 1020: 1010: 1008: 1004: 1000: 991: 988: 980:Fracture risk 977: 974: 970: 966: 962: 958: 954: 944: 941: 937: 932: 930: 926: 922: 918: 914: 910: 906: 902: 898: 894: 884: 882: 872: 870: 866: 862: 858: 854: 850: 846: 836: 834: 830: 826: 821: 815: 814:Health Canada 811: 807: 803: 799: 794: 792: 788: 784: 780: 776: 771: 769: 765: 761: 757: 753: 752:derealization 749: 745: 741: 737: 733: 729: 725: 721: 717: 716:sexual desire 712: 710: 700: 698: 694: 690: 685: 682: 680: 676: 672: 668: 664: 660: 655: 653: 649: 645: 641: 637: 631: 629: 625: 622:, diminished 621: 617: 613: 603: 601: 597: 588: 586: 576: 574: 569: 565: 562:ranging from 561: 554: 544: 541: 531: 529: 524: 522: 517: 515: 505: 503: 499: 495: 486: 484: 480: 470: 467: 465: 455: 452: 443: 441: 437: 433: 429: 425: 421: 417: 413: 409: 405: 395: 393: 389: 384: 376: 372: 368: 364: 360: 356: 353: 349: 345: 341: 337: 333: 328: 327: 326: 323: 321: 317: 307: 305: 301: 297: 293: 289: 285: 281: 277: 273: 269: 259: 255: 253: 249: 245: 241: 237: 233: 229: 225: 222: 219:level of the 218: 217:extracellular 213: 211: 207: 203: 199: 195: 191: 183: 179: 174: 170: 166: 164: 160: 155: 151: 147: 145: 141: 137: 133: 131: 127: 124:Clinical data 122: 119: 116: 114: 110: 107: 104: 102: 98: 95: 91: 88: 84: 80: 78: 74: 69: 64: 59: 54: 51: 50: 45: 40: 35: 30: 19: 17714: 17713: 17668:Promethazine 17653:Perphenazine 17633:Fluphenazine 17608:Clocapramine 17583:Carvotroline 17559: 17549: 17485:Antagonists: 17484: 17444: 17320: 17271:Antagonists: 17270: 17172: 17044:Clomipramine 16980: 16965: 16958: 16937:Progesterone 16824:Antagonists: 16823: 16787:Pregnenolone 16674:Escitalopram 16594:Cloperastine 16569:Blarcamesine 16525: 16434: 16433: 16418: 16406: 16403: 16393: 16303:Bietaserpine 16275:Amphetamines 16198:Mifepristone 16188:Medifoxamine 16070: 16013:Clomipramine 16008:Cianopramine 15999: 15852:Diclofensine 15822:Brasofensine 15798: 15722: 15710:Vortioxetine 15661: 15580:Escitalopram 15536: 15458:Indeloxazine 15450: 15387: 15370:Oxaprotiline 15351: 15339:Trimipramine 15294:Clomipramine 15289:Cianopramine 15284:Butriptyline 15275: 15128:Diclofensine 15098:Brasofensine 15074: 14998: 14986:Solriamfetol 14912: 14895:Teniloxazine 14855:Esreboxetine 14826: 14758:Solriamfetol 14678:Medifoxamine 14568:Dimethocaine 14558:Diclofensine 14530: 14482: 14370:Difluoropine 14365:Dichloropane 14350:Brasofensine 14336: 14324:Pyrovalerone 14300: 14225:Piperidines: 14224: 14174:Piperazines: 14173: 14081:aripiprazole 14050:clomipramine 14004:escitalopram 13833:Lorpiprazole 13823:Fabomotizole 13813:Benzoctamine 13715:Vortioxetine 13691: 13658:clomipramine 13613:escitalopram 13500:Carisoprodol 13480:Barbiturates 13471: 13356: 13322:Tandospirone 13182:Oxitriptan ( 13174: 13058:aripiprazole 13016: 12965:Metralindole 12956: 12926: 12916: 12895:Pivhydrazine 12885:Pheniprazine 12831: 12737:Trimipramine 12727:Quinupramine 12627:Clomipramine 12622:Butriptyline 12545:Teniloxazine 12540:Tandospirone 12525:Metryptamine 12520:Medifoxamine 12505:Indeloxazine 12459:Vortioxetine 12221:Escitalopram 12093:(1): 13–17. 12090: 12086: 12076: 12051:10261/202657 12021: 12017: 12010: 11975: 11971: 11961: 11928: 11924: 11918: 11885: 11881: 11875: 11848: 11844: 11834: 11791: 11787: 11778: 11753: 11749: 11743: 11708: 11704: 11698: 11671: 11667: 11633: 11629: 11600: 11580:. Retrieved 11560: 11525: 11521: 11477: 11473: 11463: 11452:. Retrieved 11432: 11425: 11405: 11398: 11365: 11361: 11355: 11344:. Retrieved 11335: 11331: 11292:(1): 19–36. 11289: 11285: 11279: 11244: 11240: 11230: 11195: 11191: 11181: 11154: 11150: 11112: 11108: 11074: 11070: 11026: 11022: 11012: 10979: 10975: 10968: 10957:. Retrieved 10924: 10920: 10910: 10880:(1): 13–22. 10877: 10873: 10867: 10832: 10828: 10818: 10781: 10777: 10767: 10732: 10680: 10676: 10624: 10620: 10613: 10578: 10574: 10564: 10533: 10527: 10490: 10486: 10476: 10465:. Retrieved 10439: 10402: 10396: 10363: 10359: 10353: 10320: 10316: 10310: 10285: 10281: 10275: 10242: 10238: 10192: 10188: 10178: 10146:(2): 35–36. 10143: 10139: 10129: 10094: 10090: 10080: 10045: 10041: 10031: 10020:. Retrieved 10006: 9989: 9985: 9975: 9945:(1): 73–78. 9942: 9938: 9932: 9907: 9903: 9859: 9851: 9832: 9826: 9789: 9785: 9775: 9742: 9738: 9732: 9708:(1): 63–74. 9705: 9701: 9691: 9666: 9662: 9656: 9613: 9609: 9602: 9565: 9561: 9551: 9516: 9512: 9464: 9460: 9450: 9425: 9421: 9415: 9382: 9378: 9372: 9337: 9333: 9323: 9310: 9306: 9269: 9265: 9255: 9241:(9): A4303. 9238: 9234: 9228: 9198:(2): 39–51. 9195: 9191: 9185: 9174:. Retrieved 9170:the original 9160: 9149:. Retrieved 9145:the original 9135: 9113:(1): 19–22. 9110: 9106: 9100: 9073: 9069: 9059: 9042: 9038: 9032: 9000:(1): 30–34. 8997: 8993: 8983: 8946: 8942: 8932: 8895: 8891: 8845: 8841: 8835: 8802: 8798: 8792: 8759: 8755: 8729:(3): 60–66. 8726: 8722: 8712: 8687: 8683: 8677: 8652: 8648: 8641: 8606: 8602: 8592: 8557: 8553: 8543: 8532:. Retrieved 8528:the original 8514: 8503:. Retrieved 8479: 8446: 8442: 8436: 8411: 8407: 8400: 8388:. Retrieved 8379: 8370: 8335: 8331: 8307:. Retrieved 8296: 8287: 8279:the original 8269: 8258:. Retrieved 8237: 8210: 8206: 8196: 8185:. Retrieved 8173: 8160: 8149:. Retrieved 8137: 8110:. Retrieved 8090: 8083: 8048: 8044: 8034: 8001: 7997: 7991: 7964: 7960: 7950: 7925: 7921: 7915: 7904:. Retrieved 7871: 7867: 7857: 7822: 7818: 7808: 7791: 7787: 7781: 7748: 7744: 7702: 7698: 7692: 7662:(1): 21–25. 7659: 7655: 7649: 7622: 7618: 7608: 7597:. Retrieved 7567:(1): 65–68. 7564: 7560: 7550: 7523: 7519: 7509: 7476: 7472: 7466: 7434:(1): 47–59. 7431: 7427: 7417: 7392: 7388: 7382: 7349: 7345: 7339: 7312: 7308: 7270: 7266: 7238: 7196: 7192: 7158: 7154: 7148: 7137:. Retrieved 7129:News-Medical 7128: 7119: 7076: 7072: 7062: 7051:. Retrieved 7042: 7033: 7000: 6996: 6989: 6978:. Retrieved 6958: 6935: 6924:. Retrieved 6915: 6905: 6883:(1): 78–84. 6880: 6876: 6870: 6835: 6831: 6821: 6786: 6782: 6772: 6737: 6733: 6723: 6688: 6684: 6674: 6631: 6627: 6620: 6593: 6589: 6579: 6544: 6540: 6530: 6493: 6489: 6448:(2): 75–85. 6445: 6441: 6431: 6420:. Retrieved 6418:. 2024-05-20 6415: 6406: 6395:. Retrieved 6391: 6382: 6357: 6353: 6347: 6335:. Retrieved 6315: 6309: 6284: 6274: 6241: 6237: 6231: 6198: 6194: 6188: 6158:(1): 91–98. 6155: 6151: 6130: 6113:(1): 29–34. 6110: 6106: 6086:. Retrieved 6050: 6046: 6033: 6000: 5996: 5955:(1): 65–76. 5952: 5948: 5921:. Retrieved 5896:2158/1317239 5878: 5874: 5812: 5808: 5798: 5765: 5761: 5755: 5728: 5724: 5714: 5677: 5673: 5663: 5646: 5642: 5636: 5625:. Retrieved 5621:the original 5616: 5612: 5602: 5569: 5565: 5559: 5525:(10): 1640. 5522: 5518: 5508: 5499: 5479: 5475: 5468: 5456:. Retrieved 5439: 5429: 5404: 5400: 5394: 5377: 5373: 5367: 5334: 5330: 5324: 5297: 5293: 5283: 5272:. Retrieved 5253: 5249: 5239: 5214: 5210: 5204: 5179: 5175: 5169: 5136: 5132: 5126: 5109: 5103: 5066: 5062: 5052: 5015: 5011: 5001: 4967:(1): 19–41. 4964: 4960: 4950: 4925: 4921: 4915: 4872: 4868: 4858: 4831: 4827: 4817: 4809:the original 4804: 4781:. Retrieved 4769: 4717: 4713: 4703: 4670: 4666: 4659: 4632: 4628: 4618: 4607:. Retrieved 4587: 4576:. Retrieved 4556: 4519: 4515: 4505: 4497:the original 4492: 4482: 4447: 4443: 4433: 4422:. Retrieved 4415:the original 4402: 4365: 4361: 4350: 4339:. Retrieved 4332:the original 4292:(1): 32–38. 4289: 4285: 4275: 4242: 4238: 4231: 4194: 4190: 4180: 4169:. Retrieved 4160: 4151: 4116: 4112: 4102: 4093: 4061: 4057: 4047: 4038: 4018: 4014: 4008: 3983: 3979: 3973: 3938: 3934: 3893: 3889: 3879: 3844: 3840: 3830: 3803: 3799: 3789: 3746: 3742: 3736: 3699: 3695: 3671:the original 3666: 3631: 3627: 3617: 3580: 3576: 3552:. Retrieved 3527: 3523: 3513: 3481:(1): 47–53. 3478: 3474: 3449:. Retrieved 3440: 3430: 3419:. Retrieved 3415: 3405: 3386: 3376: 3365:the original 3352: 3348: 3336: 3309: 3303: 3249: 3237: 3225: 3221: 3192: 3179:antagonist. 3112:vortioxetine 3106: 3095:stereoisomer 3073:(Cymbalta), 3064: 2954: 2833:Discontinued 2741:Escitalopram 2681:Escitalopram 2476:Escitalopram 2408:(additional) 2343:Comparative 2339:properties. 2334: 2318: 2314:side effects 2299: 2292: 2280: 2261:septic shock 2250: 2226: 2207:, IL-6, and 2198: 2190: 2162: 2074: 2063:Values are K 1948:Escitalopram 1866: 1850: 1845: 1818: 1800: 1786: 1763: 1755: 1740: 1689: 1677: 1676: 1552:Escitalopram 1473: 1451: 1334: 1331:Interactions 1310: 1290: 1281:medical care 1266: 1257:intrauterine 1250: 1241: 1237: 1230: 1226: 1202: 1180:suicide risk 1155: 1123: 1115: 1095: 1087:Suicide risk 1077:hyperthermia 1025:serotonergic 1022: 997: 983: 950: 933: 905:escitalopram 890: 878: 869:vortioxetine 853:indifference 842: 822: 795: 772: 713: 706: 686: 683: 656: 632: 609: 596:Side effects 594: 591:Side effects 582: 556: 537: 525: 518: 511: 498:escitalopram 492: 476: 468: 461: 449: 432:effect sizes 420:Escitalopram 401: 380: 367:escitalopram 324: 313: 296:chronic pain 265: 262:Medical uses 256: 232:reabsorption 214: 193: 189: 188: 176:Legal status 136:Drug Classes 47: 29: 17703:Venlafaxine 17683:Remoxipride 17673:Propranolol 17598:Cinnarizine 17498:Lamotrigine 17394:Pentazocine 17389:Noribogaine 17379:Nemonapride 17211:Haloperidol 17137:Spipethiane 17102:Noribogaine 17097:Nemonapride 17092:KCR-12-83.1 16932:Pentazocine 16892:Haloperidol 16797:Pridopidine 16772:Pentazocine 16689:Fluvoxamine 16609:Cyclazocine 16446:Adrenergics 16373:Valbenazine 16363:Rose bengal 16308:Deserpidine 16279:amphetamine 16229:levorphanol 16173:Dextrorphan 16126:ziprasidone 16108:pheniramine 16043:Lofepramine 16023:Desipramine 15972:Tesofensine 15962:Sibutramine 15937:Perafensine 15897:JNJ-7925476 15892:Indatraline 15837:Dasotraline 15807:Amifitadine 15786:Venlafaxine 15766:Milnacipran 15665:Etoperidone 15645:Seproxetine 15635:Pirandamine 15615:Omiloxetine 15595:Fluvoxamine 15555:Cericlamine 15545:Alaproclate 15492:levorphanol 15421:ziprasidone 15403:pheniramine 15375:Setiptiline 15360:Maprotiline 15319:Lofepramine 15299:Desipramine 15248:Tesofensine 15238:Sibutramine 15213:Perafensine 15173:JNJ-7925476 15168:Indatraline 15113:Dasotraline 15083:Amifitadine 15062:Venlafaxine 15037:Milnacipran 14966:Nomifensine 14931:Fencamfamin 14860:Lortalamine 14850:Edivoxetine 14840:Ciclazindol 14835:Alseroxylon 14783:Venlafaxine 14763:Tametraline 14753:Sibutramine 14728:Perafensine 14708:Nomifensine 14638:Indatraline 14613:Fencamfamin 14588:DOV-216,303 14583:DOV-102,677 14543:Dasotraline 14538:Ciclazindol 14496:Armodafinil 14491:Amifitadine 14440:Tesofensine 14248:Difemetorex 14093:risperidone 14071:haloperidol 14035:venlafaxine 14012:fluvoxamine 13914:from market 13843:Mepiprazole 13828:Hydroxyzine 13818:Cycloserine 13796:propranolol 13738:Flupentixol 13695:Agomelatine 13673:mirtazapine 13494:meprobamate 13428:Fludiazepam 13403:Clotiazepam 13398:Clorazepate 13279:Anxiolytics 13221:from market 13164:brexanolone 13078:risperidone 12975:Moclobemide 12957:Reversible: 12917:Reversible: 12840:Iproclozide 12775:Setiptiline 12770:Mirtazapine 12760:Maprotiline 12717:Propizepine 12702:Noxiptiline 12687:Metapramine 12677:Lofepramine 12647:Dimetacrine 12637:Desipramine 12510:Flupentixol 12495:Etryptamine 12480:Amisulpride 12475:Agomelatine 12421:Etoperidone 12398:Setiptiline 12393:Mirtazapine 12365:Nomifensine 12322:Atomoxetine 12299:Venlafaxine 12289:Milnacipran 12231:Fluvoxamine 12028:: 422–432. 12026:Elsevier BV 11756:: 155–163. 10360:Drug Safety 9631:10616/42159 9428:: 132–137. 6634:: 472–479. 6152:Sex Med Rev 5436:"Buspirone" 5018:: 141–150. 4673:(1): 1–14. 4197:: 203–215. 3227:David Healy 3208:Controversy 3091:Milnacipran 3075:venlafaxine 3051:Seproxetine 3041:Pirandamine 3021:Omiloxetine 2991:Cericlamine 2981:Alaproclate 2951:Seproxetine 2945:Pirandamine 2934:Omiloxetine 2930:(CGP-15210) 2916:Cericlamine 2907:Alaproclate 2761:Fluvoxamine 2693:Fluvoxamine 2542:Fluvoxamine 2289:Versus TCAs 2217:Macrophages 2085:Fluvoxamine 1996:Fluvoxamine 1692:hydrocodone 1602:Fluvoxamine 1442:Mirtazapine 1379:Sibutramine 1353:moclobemide 1325:monotherapy 1267:Persistent 1142:fluvoxamine 969:GI bleeding 865:agomelatine 857:amotivation 760:Netherlands 679:moclobemide 671:agomelatine 663:mirtazapine 502:Fluvoxamine 483:fluvoxamine 416:fluvoxamine 371:odds ratios 352:venlafaxine 182:In Wikidata 17732:Categories 17688:SL 82.0715 17603:Cinuperone 17578:Caramiphen 17573:Butaclamol 17473:Tapentadol 17404:Safinamide 17384:Nepinalone 17349:Clemastine 17344:5-MeO-DiPT 17339:5-MeO-DALT 17216:Ifenprodil 17181:Arketamine 17132:Selegiline 17127:Safinamide 17087:Imipramine 17049:Clorgiline 17039:Clemastine 17029:Azidopamil 17019:5-MeO-DiPT 17014:5-MeO-DALT 16947:Sertraline 16747:Nepinalone 16694:Ifenprodil 16684:Fluoxetine 16649:Dimemorfan 16618:prasterone 16579:Citalopram 16574:Captodiame 16554:Arketamine 16549:Amantadine 16507:modulators 16422:SoRI-20041 16415:SoRI-20040 16343:Ketanserin 16270:Amiodarone 16233:tapentadol 16193:Mesembrine 16163:Delucemine 16140:esketamine 16053:Pipofezine 16038:Imipramine 15957:SEP-228432 15952:SEP-228431 15922:Nefazodone 15907:Liafensine 15877:Fezolamine 15867:DOV-216303 15862:DOV-102677 15817:Bicifadine 15812:Ansofaxine 15751:Eclanamine 15746:Duloxetine 15731:Bicifadine 15705:Vilazodone 15675:Lubazodone 15670:Litoxetine 15655:Zimelidine 15650:Sertraline 15625:Paroxetine 15620:Panuramine 15590:Fluoxetine 15585:Femoxetine 15565:Dapoxetine 15560:Citalopram 15484:tapentadol 15463:Nefazodone 15446:Ephenidine 15441:Dopexamine 15324:Melitracen 15314:Imipramine 15233:SEP-228432 15228:SEP-228431 15198:Nefazodone 15183:Liafensine 15153:Fezolamine 15143:DOV-216303 15138:DOV-102677 15093:Bicifadine 15088:Ansofaxine 15047:Nafenodone 15022:Eclanamine 15017:Duloxetine 14976:Radafaxine 14956:Manifaxine 14941:Lefetamine 14916:Amineptine 14900:Viloxazine 14875:Reboxetine 14870:Nisoxetine 14748:Sertraline 14738:Radafaxine 14723:Oroxylin A 14668:Manifaxine 14658:Liafensine 14648:Lefetamine 14628:GYKI-52895 14618:Fezolamine 14603:Esketamine 14598:Ephenidine 14521:BTS 74,398 14511:Ansofaxine 14506:Amineptine 14385:FP-β-CPPIT 14380:FE-β-CPPIT 14319:Prolintane 14212:Vanoxerine 14207:Nefazodone 14089:quetiapine 14085:olanzapine 14020:sertraline 14016:paroxetine 14008:fluoxetine 14000:citalopram 13858:Oxaflozane 13786:guanfacine 13733:Quetiapine 13710:Vilazodone 13705:Tianeptine 13688:phenelzine 13628:duloxetine 13586:Pregabalin 13571:Gabapentin 13490:Carbamates 13453:Nordazepam 13408:Cloxazolam 13393:Clonazepam 13373:Bromazepam 13368:Alprazolam 13363:Adinazolam 13196:Tryptophan 13168:zuranolone 13074:quetiapine 13070:olanzapine 13066:lurasidone 13020:Selegiline 13010:-selective 12990:Toloxatone 12985:Tetrindole 12980:Pirlindole 12960:Eprobemide 12950:-selective 12930:Bifemelane 12920:Caroxazone 12880:Phenelzine 12865:Mebanazine 12845:Iproniazid 12732:Tianeptine 12712:Pipofezine 12682:Melitracen 12662:Imipramine 12642:Dibenzepin 12602:Amineptine 12550:Tianeptine 12535:Pivagabine 12530:Oxaflozane 12490:Esketamine 12454:Vilazodone 12426:Nefazodone 12355:Amineptine 12332:Viloxazine 12327:Reboxetine 12279:Duloxetine 12251:Zimelidine 12246:Sertraline 12241:Paroxetine 12226:Fluoxetine 12216:Citalopram 11582:2017-08-26 11454:2017-08-26 11346:2017-08-26 11029:(2): e79. 10959:2018-09-17 10467:2018-07-22 10022:2018-09-17 9669:(1): 1–4. 9176:2010-07-10 9151:2010-07-10 8534:2008-05-29 8505:2007-09-25 8309:2014-06-05 8260:2008-05-29 8187:2007-09-22 8151:2007-09-22 8112:2021-01-26 7906:2020-04-18 7599:2019-07-01 7139:2024-02-12 7053:2024-02-12 6980:2012-09-23 6926:2019-12-16 6496:: 792960. 6422:2024-09-15 6397:2024-09-15 6240:(Review). 6238:Med J Aust 6197:(Review). 6154:(Review). 6109:(Review). 6088:2024-03-22 5999:(Review). 5923:2023-08-15 5877:(Review). 5811:(Review). 5680:: 911489. 5627:2013-02-19 5440:StatPearls 5274:2021-04-15 4783:2013-03-02 4609:2015-01-30 4578:2015-01-30 4424:2013-02-24 4341:2013-02-20 4171:2023-01-16 3764:2108/54719 3702:(2): e45. 3554:2019-11-08 3421:2024-09-26 3295:References 3289:Dapoxetine 3212:See also: 3202:Fluoxetine 3194:Zimelidine 3187:See also: 3165:lubazodone 3161:Litoxetine 3157:antagonist 3116:modulators 3108:Vilazodone 3071:duloxetine 3031:Panuramine 3001:Femoxetine 2963:Structures 2947:(AY-23713) 2941:(WY-26002) 2939:Panuramine 2922:Femoxetine 2886:Zimelidine 2858:Structures 2850:Zimelidine 2823:Dapoxetine 2805:Structures 2797:Dapoxetine 2781:Sertraline 2771:Paroxetine 2751:Fluoxetine 2731:Citalopram 2713:Structures 2705:Sertraline 2699:Paroxetine 2687:Fluoxetine 2675:Citalopram 2608:Sertraline 2577:Paroxetine 2507:Fluoxetine 2434:Citalopram 2306:toxic dose 2265:Fluoxetine 2186:chemokines 2113:paroxetine 2105:antagonist 2101:sertraline 2052:Antagonist 2042:Sertraline 2018:Paroxetine 1974:Fluoxetine 1926:Citalopram 1887:Medication 1825:nerve cell 1804:brain zaps 1750:See also: 1732:fluoxetine 1728:paroxetine 1652:Sertraline 1627:Paroxetine 1577:Fluoxetine 1527:Citalopram 1365:selegiline 1357:phenelzine 1183:increased. 1138:sertraline 901:citalopram 798:dapoxetine 787:depression 667:tianeptine 648:nefazodone 640:sildenafil 616:anorgasmia 579:Other uses 568:anorgasmia 494:Paroxetine 428:fluoxetine 424:citalopram 412:sertraline 408:Paroxetine 388:Fluoxetine 346:, and the 344:nefazodone 340:fluoxetine 336:paroxetine 310:Depression 274:, such as 49:Drug class 17715:See also: 17693:SR-31747A 17678:Quinidine 17663:Proadifen 17648:Molindone 17623:Hypericin 17618:EMD-59983 17568:BMY-13980 17553:SKF-83959 17468:Naluzotan 17448:Berberine 17445:Agonists: 17399:RS-67,333 17334:4-MeO-PCP 17329:3-MeO-PCE 17244:Opipramol 17239:OPC-14523 17173:Agonists: 17112:RS-67,333 17057:-Deprenyl 17009:4-MeO-PCP 16989:3-MeO-PCP 16974:SOMCL-668 16966:Positive: 16962:Phenytoin 16952:SR-31742A 16927:PD-144418 16917:NPC-16377 16767:Opipramol 16762:OPC-14523 16757:Noscapine 16727:Memantine 16669:Eliprodil 16664:Donepezil 16539:5-MeO-DMT 16526:Agonists: 16435:See also: 16410:SoRI-9804 16358:Reserpine 16328:GBR-12935 16323:Efavirenz 16243:Roxindole 16221:methadone 16208:N-Me-5-HT 16178:Efavirenz 16136:3-MeO-PCP 16079:Amoxapine 15947:Pridefine 15917:Naphyrone 15781:Tofenacin 15700:Trazodone 15690:SB-649915 15685:Quipazine 15680:LY-393558 15605:Ifoxetine 15600:Indalpine 15476:methadone 15365:Mianserin 15355:Amoxapine 15223:Pridefine 15193:Naphyrone 15057:Tofenacin 15007:CP-39,332 14926:Fencamine 14921:Bupropion 14890:Tandamine 14885:Talsupram 14845:Daledalin 14743:Rimcazole 14733:Pridefine 14698:Modafinil 14623:Fluorenol 14593:Efavirenz 14526:Bupropion 14486:Adrafinil 14450:Tropoxane 14340:Altropane 14337:Tropanes: 14314:Naphyrone 14278:Pipradrol 14197:GBR-13098 14192:GBR-13069 14187:GBR-12935 14182:GBR-12783 13924:Phase III 13912:Withdrawn 13893:Validolum 13888:Tofisopam 13883:Tiagabine 13873:Picamilon 13853:Opipramol 13778:clonidine 13700:Bupropion 13643:trazodone 13533:Zopiclone 13525:Hypnotics 13515:Etifoxine 13463:Pinazepam 13448:Medazepam 13443:Lorazepam 13438:Ketazolam 13433:Halazepam 13378:Camazepam 13312:Buspirone 13231:Phase III 13219:Withdrawn 13084:Buspirone 12970:Minaprine 12905:Tedizolid 12900:Safrazine 12875:Octamoxin 12870:Nialamide 12860:Linezolid 12855:Isoniazid 12765:Mianserin 12707:Opipramol 12672:Iprindole 12652:Dosulepin 12617:Amoxapine 12573:Tricyclic 12431:Trazodone 12388:Mianserin 12360:Bupropion 12294:Tofenacin 12236:Indalpine 12185:Specific 12107:1946-9837 11796:CiteSeerX 11713:CiteSeerX 11338:(4): 25. 11077:: 82–93. 9568:(1): 25. 9340:: f6932. 9317:eMedicine 8898:(1): 75. 7896:148816505 7888:0924-9338 7561:Endocrine 7501:116561324 7346:Neurology 7093:1946-6234 6666:228877905 6374:231669986 6301:1433-9285 6266:212728659 6195:Endocrine 6180:238580777 6075:260202178 6047:Br J Nurs 6025:244347777 5913:259126886 5256:: 42–50. 5069:(5): 57. 4889:1469-493X 4286:P & T 3583:(1): 58. 3328:192055408 3011:Ifoxetine 2928:Ifoxetine 2918:(JO-1017) 2909:(GEA-654) 2876:Indalpine 2846:(Upstène) 2844:Indalpine 2799:(Priligy) 2683:(Lexapro) 2661:Serotonin 2527:(CYP2C19) 2425:Dose (mg) 2403:metabolic 2347:of SSRIs 2295:selective 2234:apoptosis 2213:microglia 2182:cytokines 2174:hepatitis 2172:(RA), or 2145:cognition 2012:7.7–16.4 1870:serotonin 1837:receptors 1724:methadone 1716:oxycodone 1491:Drug name 1462:Ibuprofen 1432:Buspirone 1386:(ecstasy) 1344:Linezolid 1317:hypomania 1293:antenatal 1073:agitation 1049:myoclonus 925:trigeminy 861:bupropion 744:anhedonia 689:trazodone 659:bupropion 652:Buspirone 644:bupropion 600:akathisia 436:Cohen's d 224:serotonin 130:Drugs.com 63:Serotonin 17658:Pimozide 17613:Dezocine 17503:Naloxone 17463:Metaphit 17458:Fourphit 17438:Unsorted 17374:Ibogaine 17314:SAS-0132 17264:UKH-1114 17221:Ketamine 17206:DKR-1051 17201:DKR-1005 17082:Ibogaine 16714:L-687384 16709:Ketamine 16397:Luteolin 16348:Lobeline 16338:Ibogaine 16237:tramadol 16183:Hypidone 16144:ketamine 16122:loxapine 15982:Tropanes 15912:Mazindol 15902:JZ-IV-10 15736:CP-39332 15695:TGBA01AD 15488:tramadol 15431:ketamine 15417:loxapine 15258:Tropanes 15188:Mazindol 15178:JZ-IV-10 14880:Talopram 14865:Mazindol 14830:Amedalin 14688:Metaphit 14683:Mesocarb 14673:Mazindol 14643:Ketamine 14445:Troparil 14202:JJC8-088 13868:Phenibut 13848:Nicotine 13768:prazosin 13581:Phenibut 13561:blockers 13468:Prazepam 13458:Oxazepam 13423:Etizolam 13413:Diazepam 13388:Clobazam 13317:Gepirone 13304:agonists 13157:GABAkine 12835:Benmoxin 12791:Tiazesim 12515:Ketamine 12500:Gepirone 12115:23796482 12068:58564142 12060:30623890 12002:22309973 11953:41954145 11945:16773951 11910:20755149 11902:12668373 11867:14517577 11818:16194787 11770:26399904 11735:18199864 11650:17017959 11576:Archived 11542:28707591 11504:26572745 11448:Archived 11390:24692832 11382:18622372 11340:Archived 11306:10760555 11271:24257390 11263:17096399 11222:31267131 11173:24613205 11129:27453459 11091:27101921 11053:22832816 11004:34659323 10996:28445690 10953:Archived 10941:28612257 10902:21501578 10894:26464458 10859:27640518 10810:20492642 10759:28315270 10705:26491662 10697:20373470 10641:27975170 10605:23670590 10519:23596418 10458:Archived 10388:19809259 10267:43121327 10259:15362595 10219:20142325 10195:: c693. 10170:23763556 10121:28947846 10072:19567715 10016:Archived 9998:21999760 9967:19802446 9924:31526279 9818:21518864 9767:37959124 9759:15784664 9724:12873279 9683:11322738 9648:25152608 9640:24935197 9594:30506151 9543:27126849 9483:24350950 9442:25985383 9407:22564982 9364:24429387 9298:24039427 9247:21893008 9212:17294355 9127:23228547 9092:23660045 9051:22946124 9024:30123033 8975:27239775 8924:23351929 8870:16720091 8827:22875385 8819:23042258 8776:28903117 8704:17054562 8669:16712945 8633:15718539 8584:15718537 8496:Archived 8463:17074941 8428:17979590 8384:Archived 8362:25433518 8303:Archived 8251:Archived 8229:16894062 8178:Archived 8142:Archived 8106:Archived 8075:29482205 8026:37959124 8018:15784664 7983:24358002 7942:21768799 7900:Archived 7874:: S855. 7849:29708207 7800:23196265 7765:27495351 7727:20622369 7719:25667198 7676:26547857 7641:27055202 7593:Archived 7589:32286954 7581:25091520 7542:22258738 7493:21542658 7458:17506225 7409:16443409 7374:11941911 7366:23077009 7331:18606952 7287:21190637 7221:46551382 7213:15794724 7175:27514297 7133:Archived 7111:36599005 7047:Archived 7025:28057842 7017:10213794 6971:Archived 6943:Archived 6920:Archived 6862:24941178 6813:24646010 6764:26139049 6715:19587851 6658:33516560 6612:23823799 6571:26407780 6522:34970173 6464:34908941 6328:Archived 6258:32172535 6215:29675596 6172:34627736 6127:28778697 6079:Archived 6067:37495413 6017:34791958 5979:34719438 5917:Archived 5905:37294623 5839:33998993 5790:54621798 5782:30503727 5747:22573230 5706:36188547 5655:12429073 5586:19440080 5551:31591339 5496:34247952 5458:4 August 5452:Archived 5448:30285372 5421:16946173 5351:19512977 5316:23728643 5268:Archived 5196:19289334 5161:20944428 5118:21406165 5095:31126061 5044:21701626 4993:27713241 4942:17983899 4907:34780067 4850:21414249 4774:Archived 4744:29620793 4695:40412606 4687:11472786 4651:21733234 4600:Archived 4569:Archived 4548:22226028 4539:2299/216 4493:Medscape 4474:19588448 4465:10576545 4394:25081580 4308:22346334 4267:21795838 4259:16714326 4223:22665997 4165:Archived 4143:34029378 4090:29270136 4035:25979317 4021:: 60–2. 4000:17182286 3965:29477251 3912:28718394 3871:22393205 3822:20800012 3781:10323933 3773:20571143 3728:18303940 3609:28178949 3548:Archived 3544:20520282 3505:20051569 3445:Archived 3258:See also 3177:receptor 3154:receptor 3132:receptor 2852:(Zelmid) 2707:(Zoloft) 2689:(Prozac) 2677:(Celexa) 2645:Marketed 2558:CYP2D6 ( 2536:120–500 2523:CYP2D6, 2178:melanoma 2125:receptor 2107:of the σ 2099:, while 2097:receptor 2058:110–197 2036:≥14,562 1990:296–365 1942:252–348 1846:reuptake 1778:seizures 1758:overdose 1746:Overdose 1720:tramadol 1704:morphine 1468:Naproxen 1395:Tramadol 1061:migraine 1041:sweating 957:warfarin 947:Bleeding 940:5-HTTLPR 881:glaucoma 697:priapism 638:such as 614:such as 383:Cochrane 228:limiting 196:) are a 101:ATC code 77:Synonyms 17528:UMB-116 17523:UMB-103 17518:UMB-101 17513:UMB-100 17304:MIN-101 17294:CT-1812 17284:BD-1067 17279:BD-1008 17186:BD-1047 17122:Saffron 17107:RHL-033 16877:Dup-734 16862:BD-1067 16857:BD-1063 16852:BD-1060 16847:BD-1047 16842:BD-1031 16837:BD-1008 16782:PRE-084 16599:Cocaine 16564:BD-1052 16333:GZ-793A 16277:(e.g., 16215:(e.g., 16213:Opioids 16134:(e.g., 16120:(e.g., 16086:(e.g., 16074:A-80426 16071:Others: 16033:Doxepin 15986:cocaine 15984:(e.g., 15932:NS-2359 15927:Nefopam 15882:HDMP-28 15872:EXP-561 15832:Cocaine 15761:McN5652 15640:RTI-353 15470:(e.g., 15468:Opioids 15429:(e.g., 15415:(e.g., 15393:(e.g., 15388:Others: 15309:Doxepin 15262:cocaine 15260:(e.g., 15208:NS-2359 15203:Nefopam 15158:HDMP-28 15148:EXP-561 15108:Cocaine 15032:McN5652 14951:LR-5182 14713:NS-2359 14703:Nefopam 14663:LR-5182 14608:EXP-561 14483:Others: 14435:RTI-336 14430:RTI-229 14425:RTI-177 14420:RTI-150 14415:RTI-126 14410:RTI-121 14405:RTI-113 14400:RTI-112 14360:Cocaine 14258:HDMP-28 14177:DBL-583 13838:Mebicar 13794:(e.g., 13776:(e.g., 13766:(e.g., 13692:Others: 13686:(e.g., 13671:(e.g., 13656:(e.g., 13641:(e.g., 13626:(e.g., 13611:(e.g., 13492:(e.g., 13482:(e.g., 13475:Alpidem 13472:Others: 13089:Lithium 12657:Doxepin 12189:and/or 12030:Bibcode 11993:3367101 11826:6599566 11784:Healy D 11495:4825949 11213:6606856 11044:3309556 10949:4040496 10850:5050394 10801:2881105 10649:3322646 10596:3773671 10510:3627130 10380:7576268 10345:5287418 10337:8709713 10302:1586402 10210:2817754 10161:3683877 10112:5601969 10063:2704133 9959:8880055 9809:3107316 9585:6269438 9534:4851729 9491:9064353 9387:Bibcode 9355:3898424 9289:3770341 9015:6096863 8966:9987176 8915:3556001 8850:Bibcode 8784:4830115 8471:2390497 8353:8556660 8066:5885255 7974:3865832 7840:5914744 7773:5610316 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4777:(PDF) 4766:(PDF) 4691:S2CID 4603:(PDF) 4596:(PDF) 4572:(PDF) 4565:(PDF) 4418:(PDF) 4411:(PDF) 4335:(PDF) 4328:(PDF) 4263:S2CID 3777:S2CID 3674:(PDF) 3663:(PDF) 3368:(PDF) 3357:S2CID 3345:(PDF) 3102:SNRIs 3087:SNRIs 3067:SNRIs 2627:25–26 2612:80–95 2599:20–50 2581:50–90 2565:12–15 2533:20–60 2530:24–96 2514:20–45 2511:60–80 2498:10–20 2495:27–32 2467:20–40 2201:IL-1β 2055:5,297 2049:32–57 2009:8,439 2003:17–36 1939:5,410 1821:brain 1400:5-HTP 1321:mania 1037:fever 810:SNRIs 585:anger 194:SSRIs 106:N06AB 18:SSRIs 17493:AZ66 17488:AHD1 17429:W-18 17355:DiPT 17227:MDMA 17147:W-18 17063:DiPT 16720:MDMA 16704:IPAB 16585:CGRP 16298:AZIK 16287:MDMA 15776:PPPA 15519:SRIs 15508:SERT 15052:PPPA 14809:NRIs 14309:MDPV 14156:DRIs 14042:TCAs 13650:TCAs 13557:VDCC 13345:PAMs 13333:GABA 13293:5-HT 13283:N05B 13150:SAMe 12590:TCAs 12575:and 12310:NRIs 12172:N06A 12111:PMID 12103:ISSN 12056:PMID 11998:PMID 11941:PMID 11898:PMID 11863:PMID 11814:PMID 11766:PMID 11731:PMID 11684:ISBN 11646:PMID 11606:ISBN 11566:ISBN 11538:PMID 11500:PMID 11438:ISBN 11411:ISBN 11378:PMID 11302:PMID 11259:PMID 11218:PMID 11169:PMID 11125:PMID 11087:PMID 11049:PMID 10992:PMID 10937:PMID 10890:PMID 10855:PMID 10806:PMID 10755:PMID 10745:ISBN 10693:PMID 10637:PMID 10601:PMID 10538:ISBN 10515:PMID 10448:ISBN 10415:ISBN 10376:PMID 10333:PMID 10298:PMID 10255:PMID 10215:PMID 10166:PMID 10117:PMID 10068:PMID 9994:PMID 9955:PMID 9920:PMID 9878:ISBN 9837:ISBN 9814:PMID 9755:PMID 9720:PMID 9679:PMID 9636:PMID 9590:PMID 9539:PMID 9479:PMID 9438:PMID 9403:PMID 9360:PMID 9294:PMID 9243:PMID 9208:PMID 9123:PMID 9088:PMID 9047:PMID 9020:PMID 8971:PMID 8943:BJOG 8920:PMID 8866:PMID 8815:PMID 8772:PMID 8700:PMID 8665:PMID 8629:PMID 8580:PMID 8524:MHRA 8492:MHRA 8459:PMID 8424:PMID 8392:2022 8358:PMID 8336:2014 8225:PMID 8096:ISBN 8071:PMID 8014:PMID 7979:PMID 7938:PMID 7884:ISSN 7845:PMID 7796:PMID 7761:PMID 7715:PMID 7672:PMID 7637:PMID 7577:PMID 7538:PMID 7489:PMID 7454:PMID 7405:PMID 7362:PMID 7327:PMID 7283:PMID 7243:ISBN 7209:PMID 7171:PMID 7107:PMID 7089:ISSN 7013:PMID 6893:PMID 6858:PMID 6809:PMID 6760:PMID 6711:PMID 6654:PMID 6608:PMID 6567:PMID 6518:PMID 6460:PMID 6358:1838 6339:2023 6297:ISSN 6254:PMID 6211:PMID 6168:PMID 6123:PMID 6063:PMID 6013:PMID 5975:PMID 5901:PMID 5835:PMID 5778:PMID 5743:PMID 5702:PMID 5651:PMID 5582:PMID 5547:PMID 5492:PMID 5460:2024 5444:PMID 5417:PMID 5382:PMID 5347:PMID 5312:PMID 5227:PMID 5192:PMID 5149:PMID 5114:PMID 5091:PMID 5040:PMID 4989:PMID 4938:PMID 4903:PMID 4885:ISSN 4873:2021 4846:PMID 4740:PMID 4718:2018 4683:PMID 4647:PMID 4544:PMID 4470:PMID 4448:2009 4390:PMID 4304:PMID 4255:PMID 4219:PMID 4139:PMID 4117:2021 4086:PMID 4031:PMID 3996:PMID 3961:PMID 3908:PMID 3867:PMID 3818:PMID 3769:PMID 3724:PMID 3605:PMID 3540:PMID 3501:PMID 3475:JAMA 3453:2011 3391:ISBN 3324:OCLC 3314:ISBN 3216:and 3173:5-HT 3150:5-HT 3148:and 3143:5-HT 3128:5-HT 2552:2.89 2517:4.05 2444:3.76 2382:logP 2352:SSRI 2246:MAPK 2184:and 2153:SERT 2046:0.29 2022:0.13 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