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497:(liver cells) and their microenvironment and develops microfabrication tools to improve cellular therapies for liver disease in an approach referred to as hepatic tissue engineering. The goal is to maximize hepatocyte function, facilitate design of effective cellular therapies for liver disease, and improve fundamental understanding of liver physiology and pathophysiology. The approach has been used to study diseases including
246:, United States. Bhatia's research investigates applications of micro- and nano-technology for tissue repair and regeneration. She applies ideas from computer technology and engineering to the design of miniaturized biomedical tools for the study and treatment of diseases, in particular
745:, in the Technology, the Economy and Employment category "for her seminal work in tissue engineering and disease detection, including the cultivation of functional liver cells outside of the human body, and for her passion in promoting the advancement of women in the STEM fields."
456:
Bhatia's doctoral work focused on the development of a way to keep liver cells functioning outside of the human body. She adapted ideas from computer chip design and engineering to the microfabrication of a substrate for liver cells. She successfully applied techniques from
441:. While at MIT, she helped to start Keys to Empowering Youth, a program that brings middle-school girls to visit hi-tech labs as a way to encourage them in science and technology. Bhatia and her husband, Jagesh Shah have two daughters.
1877:
March, Sandra; Ng, Shengyong; Velmurugan, Soundarapandian; Galstian, Ani; Shan, Jing; Logan, David J.; Carpenter, Anne E.; Thomas, David; Sim, B. Kim Lee; Mota, Maria M.; Hoffman, Stephen L.; Bhatia, Sangeeta N. (July 2013).
405:
492:
Bhatia's research in the
Laboratory for Multiscale Regenerative Technologies (LMRT) continues to apply micro- and nanotechnology ideas to tissue repair and regeneration. She studies the interactions between
547:
that can be designed to perform complex tasks. They may be able to home in on a tumor, signal changes in cells or tissues, enhance imaging, or release a therapeutic component. In 2002, Bhatia worked with
360:
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with the goal of supporting larger tissue structures such as an artificial liver. Her work was one of the first projects at MIT in the area of biological micro-electromechanical systems, or
2429:
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2014:
Mann, AP; Scodeller, P; Hussain, S; Joo, J; Kwon, E; Braun, GB; Mölder, T; She, Z; Kotamraju, VR; Ranscht, B; Krajewski, S; Teesalu, T; Bhatia, S; Sailor, MJ; Ruoslahti, E (2016).
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Bhatia holds a number of patents for both clinical and biotechnological applications of engineering principles. In 2015, her company
Glympse Bio received initial funding from
564:
targeting of tumors. By adding tumor-enzyme molecules to nanoparticles she has also created specialized nanoparticles that can react with diseased tissue to create synthetic
470:
528:
cell-based assays. These are used to support the study of parasites and explore possible differential drug sensitivity and identify new anti-relapse medicines for
336:
in India. Bhatia was motivated to become an engineer after her 10th grade biology class and a trip with her father into an MIT lab to see a demonstration of an
2334:
1852:"Discovering new molecules to target the relapse Prof Sangeeta Bhatia Prof Sangeeta Bhatia, Director, Laboratory for Multiscale Regenerative Technologies, MIT"
1314:
356:
587:
at Aspect
Ventures. In 2018, Glympse received $ 22 million to further develop âactivity sensorsâ to identify diseases and monitor patient response to drugs.
465:, to create a substrate that would support growth of a functioning microliver in a dish. Bhatia also used co-cultures of more than one cell type to prevent
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205:
1170:
1083:
Schultz, Jerome; Mrksich, Milan; Bhatia, Sangeeta N.; Brady, David J.; Ricco, Antionio J.; Walt, David R.; Wilkins, Charles L., eds. (July 15, 2006).
680:
Schultz, Jerome; Mrksich, Milan; Bhatia, Sangeeta N.; Brady, David J.; Ricco, Antionio J.; Walt, David R.; Wilkins, Charles L., eds. (July 15, 2006).
2099:
1370:"Interview: Sangeeta Bhatia Distillations talks to the 2019 Othmer Gold Medal winner about her work using nanotechnology to detect and treat disease"
430:
756:"for her dedication to the next generation of scientists, and groundbreaking inventions to improve human health and patient care on a global scale."
805:
711:
1406:"The Organist When molecular biology methods failed her, Sangeeta Bhatia turned to engineering and microfabrication to build a liver from scratch"
426:
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which convinced her to pursue graduate study the field. After graduating with honors in 1990, Bhatia was initially rejected from the
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387:(UCSD) in 1998. As an assistant professor, Bhatia was awarded a five-year Packard Fellowship for Science and Engineering from the
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485:. She is interested in using arrays of living cells as high-throughput platforms to study fundamental aspects of Bio-MEMS in
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for tissue engineering and tissue regeneration technologies, stem cell differentiation, and preclinical drug evaluation.
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Chin, Vicki I.; Taupin, Philippe; Sanga, Sandeep; Scheel, John; Gage, Fred H.; Bhatia, Sangeeta N. (November 5, 2004).
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Bhatia currently directs the
Laboratory for Multiscale Regenerative Technologies at MIT and is affiliated with
372:
238:âs Institute for Medical Engineering and Science and Electrical Engineering and Computer Science (EECS) at the
160:
404:
In 2005, she left UCSD and joined the MIT faculty in the
Division of Health Sciences & Technology and the
1826:"Tracking dormant malaria Novel technology could allow researchers to develop and test new antimalaria drugs"
539:
as tools for biological studies and as multifunctional agents for cancer therapies. Interests center around
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2016:"A peptide for targeted, systemic delivery of imaging and therapeutic compounds into acute brain injuries"
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Shan, Jing; Stevens, Kelly R.; Trehan, Kartik; Underhill, Gregory H.; Chen, Alice A.; Bhatia, Sangeeta N.
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1880:"A Microscale Human Liver Platform that Supports the Hepatic Stages of Plasmodium falciparum and vivax"
438:
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332:, Massachusetts; her father was an engineer and her mother was one of the first women to receive an
2100:"MIT spinout from Sangeeta Bhatia's lab gets a $ 22M round to develop new disease and drug sensors"
410:
273:
243:
1955:
Akerman, M. E.; Chan, W. C. W.; Laakkonen, P.; Bhatia, S. N.; Ruoslahti, E. (September 16, 2002).
2073:"Earlier Detection of Cancer May Be Enhanced by MIT Discovery with Biomarkers Collected in Urine"
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in 1999. She was named a 2001 "Teacher of the Year" in the
Bioengineering Department at the
2364:
2027:
1968:
1405:
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masters program. She was later accepted to the HST MD-PhD program where she was advised by
1203:"UC San Diego Bioengineering Professor Receives Prestigious Packard Foundation Fellowship"
8:
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1972:
371:. She received a PhD in 1997 and an MD in 1999, and completed postdoctoral training at
2048:
2015:
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1543:
1517:
1315:"Sangeeta Bhatia: the biotech entrepreneur advocating for gender equity in STEM fields"
1295:. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
1233:
Other 2001 Teacher of the Year award recipients include: Sangeeta Bhatia
Bioengineering
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Bhatia is the recipient of a number of awards and honors including the following:
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1793:. In Meyer, Ulrich; Meyer, Thomas; Handschel, Jörg; Wiesmann, Hans Peter (eds.).
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in the world under the age of 35. She was also named a "Scientist to Watch" by
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Bhatia's laboratory is also involved in a multidisciplinary effort to develop
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Bhatia, S. N.; Underhill, G. H.; Zaret, K. S.; Fox, I. J. (July 16, 2014).
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992:"Four MIT faculty named 2015 fellows of the National Academy of Inventors"
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1344:"Scene and Herd: Bhatia wins Heinz Award, focuses on tissue engineering"
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308:(2004), written for senior-level and first-year graduate courses with
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in 2006. She has received multiple awards and has been elected to the
1789:
Park, J.-K.; Lee, S.-K.; Lee, D.-H.; Kim, Y.-J. (February 11, 2009).
498:
251:
967:"Two from MIT elected to the National Academy of Medicine for 2019"
482:
429:. Bhatia is a strong advocate for gender equity and inclusivity in
1022:. Microsystems. Vol. 5. Boston: Kluwer Academic Publishers.
917:"National Academy of Sciences elects six MIT professors for 2017"
603:. Microsystems. Vol. 5. Boston: Kluwer Academic Publishers.
529:
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in France. She and her coworkers have also used techniques from
255:
1707:
Microfabrication in Tissue
Engineering and Bioartificial Organs
1251:. Howard Hughes Medical Institute. May 27, 2008. Archived from
1019:
Microfabrication in tissue engineering and bioartificial organs
806:"Cancer-Fighting Inventor Sangeeta Bhatia Wins $ 500,000 Prize"
600:
Microfabrication in tissue engineering and bioartificial organs
352:
329:
300:(1999). Bhatia co-authored the first undergraduate textbook on
298:
Microfabrication in tissue engineering and bioartificial organs
1173:. Harvard-MIT Health Science & Technology. Archived from
569:
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Members of the United States
National Academy of Engineering
2129:
Australian
Academy of Technological Sciences and Engineering
1795:
Fundamentals of tissue engineering and regenerative medicine
712:
Australian Academy of Technological Sciences and Engineering
556:
to develop phage-derived peptide-targeted nanomaterials, or
477:
to create a lattice of sugar as a framework for a synthetic
942:"Eight from MIT elected to National Academy of Engineering"
1954:
1541:
1223:. No. Winter. UCSD Jacobs School of Engineering. 2002
572:
samples. Another project involves engineering beneficial
2435:
Members of the United States National Academy of Sciences
2077:
Senior Journal: Health & Medicine for Senior Citizens
1876:
1542:
Borenstein, J. T.; Vunjak-Novakovic, G. (November 2011).
1146:"Sangeeta N. Bhatia, MD, PhD Investigator / 2009âPresent"
1082:
679:
406:
Department of Electrical Engineering and Computer Science
333:
235:
1457:"3D-printed sugar network to help grow artificial liver"
433:. Bhatia helped to found the Diversity Committee of the
206:âThis tiny particle could roam your body to find tumorsâ
2300:
2176:"Utrecht University to present two honorary doctorates"
2013:
1628:
1487:"Microfabricated platform for studying stem cell fates"
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357:
Harvard-MIT Division of Health Sciences and Technology
1685:. Laboratory for Multiscale Regenerative Technologies
1484:
2301:
Laboratory for Multiscale Regenerative Technologies
1740:"Micromechanical control of cell-cell interactions"
1068:Nahmias, Yaakov; Bhatia, Sangeeta N., eds. (2009).
1009:
759:2011, BEAM (Brown Engineering Alumni Medal) Award,
630:. Upper Saddle River, N.J.: Pearson Prentice Hall.
1086:Biosensing: International Research and Development
1057:. Upper Saddle River, N.J.: Pearson Prentice Hall.
1051:Palsson, Bernhard Ă.; Bhatia, Sangeeta N. (2004).
683:Biosensing: International Research and Development
576:with the ability to detect or treat cancer cells.
318:Biosensing: International Research and Development
219:âSangeeta Bhatia, 2014 Lemelson-MIT Prize Winnerâ
101:Nanotechnology for tissue repair and regeneration
2321:
1697:
1275:"Indian chosen for prestigious scientists' body"
234:and the John J. and Dorothy Wilson Professor at
208:, Sangeeta Bhatia, TED Talks Live, November 2015
1961:Proceedings of the National Academy of Sciences
1935:Institute for Medical Engineering & Science
1744:Proceedings of the National Academy of Sciences
1631:"Cell and tissue engineering for liver disease"
892:"Sangeeta Bhatia Looks at Life's Architecture"
427:Koch Institute for Integrative Cancer Research
408:. Bhatia was named a "Scientist to Watch" by
2335:Brown University School of Engineering alumni
2198:"Announcing our 2017 Catalyst Award Winners!"
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1393:
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2248:"Dr. Sangeeta Bhatia - Lemelson-MIT Program"
1738:Hui, E. E.; Bhatia, S. N. (March 27, 2007).
1624:
1622:
734:2017, Catalyst Award, Science Club for Girls
626:Palsson, Bernhard; Bhatia, Sangeeta (2004).
469:of the liver cells, building on the work of
444:In 2015, Bhatia was elected a member of the
2460:Members of the National Academy of Medicine
1114:
347:where she joined a research group studying
323:
296:Bhatia's dissertation became the basis for
2223:"The Heinz Awards :: Sangeeta Bhatia"
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862:"Innovators Under 35: Sangeeta Bhatia, 35"
799:
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653:Nahmias, Yaakov; Bhatia, Sangeeta (2009).
395:, and was named an Innovator under 35 by
31:
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1990:
1980:
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1654:
1619:
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1089:. Springer Science & Business Media.
686:. Springer Science & Business Media.
516:her lab has worked on the development of
328:Bhatia's parents emigrated from India to
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1423:
1217:"Keiko Nomura Named Teacher of the Year"
1138:
803:
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1948:
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1680:"HEPATIC TISSUE ENGINEERING (ca. 2010)"
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1115:Seftel, Josh; Lewis, Susan K. (2009).
1015:
761:Brown University School of Engineering
596:
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1920:
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1782:
1367:
1361:
1342:Wood, Martha Crosier (May 26, 2015).
1200:
889:
804:Vickmark, Bryce (September 9, 2014).
754:Massachusetts Institute of Technology
508:Since 2008, with assistance from the
240:Massachusetts Institute of Technology
170:Massachusetts Institute of Technology
86:Massachusetts Institute of Technology
2415:20th-century Indian women scientists
2007:
1671:
1475:
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1205:. UCSD Jacobs School of Engineering.
1103:
1070:Microdevices in biology and medicine
880:
851:
655:Microdevices in biology and medicine
314:Microdevices in Biology and Medicine
2330:Howard Hughes Medical Investigators
2071:Trafton, Anne (December 17, 2012).
1731:
1160:
1117:"The Many Sides of Sangeeta Bhatia"
774:David and Lucile Packard Foundation
514:Bill & Melinda Gates Foundation
389:David and Lucile Packard Foundation
385:University of California, San Diego
165:University of California, San Diego
13:
1201:Hagen, Denine (December 1, 1999).
14:
2471:
2355:American people of Indian descent
2340:MIT School of Engineering faculty
2294:
2098:Carroll, John (October 9, 2018).
1594:3D Multiscale Physiological Human
1544:"Engineering Tissue with BioMEMS"
1404:Scudellari, Megan (May 1, 2013).
1148:. Howard Hughes Medical Institute
890:Nadis, Steve (February 1, 2006).
383:Bhatia joined the faculty at the
343:Bhatia studied bioengineering at
2345:MIT School of Engineering alumni
2202:Science Club for Girls community
1597:. London: Springer. p. 39.
1494:Biotechnology and Bioengineering
359:(HST) but was accepted into the
213:
200:
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2168:
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1957:"Nanocrystal targeting in vivo"
1818:
1431:"Engineering Artificial Organs"
1307:
1267:
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767:Howard Hughes Medical Institute
446:National Academy of Engineering
416:Howard Hughes Medical Institute
283:National Academy of Engineering
115:Howard Hughes Medical Institute
2405:20th-century Indian biologists
1931:"Sangeeta Bhatia Core Faculty"
1635:Science Translational Medicine
984:
959:
934:
909:
823:
435:Biomedical Engineering Society
373:Massachusetts General Hospital
261:In 2003, she was named by the
161:Massachusetts General Hospital
1:
2410:20th-century Indian engineers
2350:Harvard Medical School alumni
1293:"Sangeeta N. Bhatia, MD, PhD"
1249:"The 2008 HHMI Investigators"
779:
710:2023, Overseas Fellow of the
510:Medicines for Malaria Venture
437:, and is involved with MIT's
291:National Academy of Inventors
2445:21st-century women engineers
2440:20th-century women engineers
1704:Bhatia, Sangeeta N. (1999).
1647:10.1126/scitranslmed.3005975
1368:Rinde, Meir (July 9, 2019).
1171:"People: Sangeeta N. Bhatia"
423:Brigham and Women's Hospital
393:Jacobs School of Engineering
287:National Academy of Medicine
279:National Academy of Sciences
7:
2455:21st-century American women
2420:20th-century American women
2277:Brown School of Engineering
1376:. Science History Institute
1125:Public Broadcasting Service
471:Christiane Guguen-Guillouzo
451:
230:(born 1968) is an American
10:
2476:
1896:10.1016/j.chom.2013.06.005
831:"2003 Innovators Under 35"
772:1999, Packard Fellowship,
728:2018, honorary Doctorate,
439:Society of Women Engineers
2395:American women biologists
2154:Science History Institute
1797:. Springer. p. 407.
1028:10.1007/978-1-4615-5235-2
1016:Bhatia, Sangeeta (1999).
723:Science History Institute
701:
609:10.1007/978-1-4615-5235-2
597:Bhatia, Sangeeta (1999).
378:
312:. She was a co-editor of
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68:
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30:
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18:American nanotechnologist
2450:American women academics
2380:American women engineers
2360:Indian nanotechnologists
2308:publications indexed by
1591:Thalmann, Nadia (2014).
1560:10.1109/MPUL.2011.942764
657:. Boston: Artech House.
590:
324:Early life and education
244:Cambridge, Massachusetts
2400:Indian women biologists
1884:Cell Host & Microbe
1757:10.1073/pnas.0608660104
1072:. Boston: Artech House.
743:Heinz Family Foundation
568:detectable in blood or
2390:Indian women engineers
2125:"Sangeeta Bhatia FTSE"
1982:10.1073/pnas.152463399
418:investigator in 2008.
361:Mechanical Engineering
340:for cancer treatment.
91:Harvard Medical School
2375:American bioengineers
1791:"Bioartificial Liver"
1177:on September 19, 2008
866:MIT Technology Review
836:MIT Technology Review
519:Plasmodium falciparum
414:in 2006 and became a
398:MIT Technology Review
264:MIT Technology Review
37:Bhatia in 2023 at MIT
2273:"BEAM Award Winners"
1255:on February 27, 2009
545:nanoporous materials
117:investigator (2008)
2425:Indian bioengineers
2227:www.heinzawards.net
2178:. February 16, 2017
2150:"Othmer Gold Medal"
2040:10.1038/ncomms11980
2032:2016NatCo...711980M
1973:2002PNAS...9912617A
1967:(20): 12617â12621.
1832:. February 22, 2018
581:Kiran Mazumdar-Shaw
355:program run by the
232:biological engineer
2385:Women bioengineers
1054:Tissue engineering
750:Lemelson-MIT Prize
730:Utrecht University
628:Tissue engineering
338:ultrasound machine
306:Tissue engineering
302:tissue engineering
267:as one of the top
228:Sangeeta N. Bhatia
221:, January 29, 2015
151:Tissue engineering
120:LemelsonâMIT Prize
110:Packard Fellowship
25:Sangeeta N. Bhatia
1804:978-3-540-77755-7
1750:(14): 5722â5726.
1717:978-1-4613-7386-5
1604:978-1-4471-6275-9
1506:10.1002/bit.20254
1096:978-1-4020-4058-0
1037:978-1-4613-7386-5
719:Othmer Gold Medal
693:978-1-4020-4058-0
664:978-1-59693-405-4
618:978-1-4613-7386-5
467:dedifferentiation
349:artificial organs
225:
224:
190:
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177:Academic advisors
137:Scientific career
129:Othmer Gold Medal
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843:August 15,
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725:and others
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483:Bio-MEMS
452:Research
425:and the
320:(2005).
172:(2005â )
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1518:S2CID
1490:(PDF)
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570:urine
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Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
