2755:
7485:
6855:
1792:
1769:
7770:
6150:
6135:
6120:
7320:
6585:
6315:
6300:
5595:
5580:
5565:
6675:
6660:
6645:
6630:
6615:
6600:
5835:
5820:
5805:
5790:
7755:
5415:
5280:
6795:
1691:
1666:
5265:
5295:
8205:
7155:
6780:
6045:
6030:
6015:
6000:
6990:
5730:
7245:
7230:
6765:
8265:
8130:
8115:
7710:
5700:
5715:
6180:
5220:
5205:
7215:
6165:
5685:
5160:
8280:
7410:
6195:
6240:
5910:
5895:
7860:
7845:
7830:
6075:
6060:
5985:
5865:
6090:
6840:
7050:
6810:
8220:
7575:
7560:
7170:
6105:
5370:
7275:
7740:
5445:
5340:
7815:
7800:
6945:
5670:
5655:
5640:
5625:
5940:
5355:
5175:
7725:
7335:
6210:
7290:
6465:
6255:
5130:
5115:
7200:
7185:
8055:
6360:
8145:
7140:
6870:
6825:
5505:
5490:
5475:
5100:
6345:
5760:
5535:
5520:
5460:
7095:
7080:
5880:
5775:
5190:
6330:
5235:
5145:
8085:
6495:
6225:
8310:
8295:
8070:
6480:
7695:
6570:
7995:
7065:
7620:
7605:
6975:
7590:
7020:
6510:
6450:
6435:
5250:
7125:
7635:
7110:
6690:
5850:
7650:
6525:
7980:
7965:
7665:
6960:
8250:
5385:
7305:
5610:
5400:
5325:
5310:
7005:
6735:
5430:
8100:
7680:
7380:
7395:
1798:
1697:
5550:
2043:
7470:
6930:
6915:
6900:
6885:
5745:
6285:
8235:
5925:
8190:
8175:
8160:
6720:
7035:
7260:
6750:
7455:
8040:
7785:
7350:
6705:
8025:
8010:
6390:
6375:
7440:
7425:
7365:
7545:
7530:
7515:
7500:
6540:
6420:
6405:
5970:
5955:
6555:
7950:
7935:
7920:
7905:
7890:
7875:
10276:
6270:
3040:
31:
3225:
abundantly expressed in all arterial vessel wall constituents, thrombin has the potential to exert pro-atherogenic actions such as inflammation, leukocyte recruitment into the atherosclerotic plaque, enhanced oxidative stress, migration and proliferation of vascular smooth muscle cells, apoptosis and angiogenesis.
3102:
promoting the correct conformation of the catalytic residues. Contrary to crystal structures of active thrombin, hydrogen-deuterium exchange mass spectrometry studies indicate that this N-terminal Ile-NH3 does not become inserted into the β-barrel in the apo form of thrombin. However, binding of the
3224:
Beyond its key role in the dynamic process of thrombus formation, thrombin has a pronounced pro-inflammatory character, which may influence the onset and progression of atherosclerosis. Acting via its specific cell membrane receptors (protease activated receptors: PAR-1, PAR-3 and PAR-4), which are
3350:
blood. According to the manufacturer it can be used to produce new kinds of mixed meats (for example combining beef and fish seamlessly). The manufacturer also states that it can be used to combine whole muscle meat, form and portion these, thus cutting down on production costs without a loss in
57:
4350:
Chapman WC, Singla N, Genyk Y, McNeil JW, Renkens KL, Reynolds TC, Murphy A, Weaver FA (August 2007). "A phase 3, randomized, double-blind comparative study of the efficacy and safety of topical recombinant human thrombin and bovine thrombin in surgical hemostasis".
7484:
6854:
2917:
activity has been measured to be around 1.1 units/mL. Newborn levels of thrombin steadily increase after birth to reach normal adult levels, from a level of around 0.5 units/mL 1 day after birth, to a level of around 0.9 units/mL after 6 months of life.
3097:
is converted to active thrombin by proteolysis of an internal peptide bond, exposing a new N-terminal Ile-NH3. The historic model of activation of serine proteases involves insertion of this newly formed N-terminus of the heavy chain into the
3130:(2 pairs), and is not related to gender or blood type. Homozygous mutations increase the risk of thrombosis more than heterozygous mutations, but the relative increased risk is not well documented. Other potential risks for
7769:
6149:
6134:
6119:
7319:
4386:
Singla NK, Ballard JL, Moneta G, Randleman CD, Renkens KL, Alexander WA (July 2009). "A phase 3b, open-label, single-group immunogenicity and safety study of topical recombinant thrombin in surgical hemostasis".
6584:
6314:
6299:
5594:
5579:
5564:
1805:
1704:
6674:
6659:
6644:
6629:
6614:
6599:
5834:
5819:
5804:
5789:
7754:
5414:
5279:
6794:
5264:
5294:
8204:
7154:
6779:
6044:
6029:
6014:
5999:
6989:
5729:
7244:
7229:
6764:
8264:
3055:. The catalytic domain is released from prothrombin fragment 1.2 to create the active enzyme thrombin, which has a molecular weight of 36,000 Da. Structurally, it is a member of the large
8129:
8114:
7709:
5699:
3284:
are prothrombin-rich coagulation factor preparations that can be used to correct deficiencies (usually due to medication) of prothrombin. Indications include intractable bleeding due to
3086:
as a cofactor leads to cleavage of the Gla and two
Kringle domains (forming together a fragment called fragment 1.2) and leave thrombin, consisting solely of the serine protease domain.
5714:
6179:
5219:
5204:
3911:
Huang M, Rigby AC, Morelli X, Grant MA, Huang G, Furie B, Seaton B, Furie BC (September 2003). "Structural basis of membrane binding by Gla domains of vitamin K-dependent proteins".
7214:
6164:
7493:: THE CRYSTAL STRUCTURE OF FIBRINOGEN-AA PEPTIDE 1-23 (F8Y) BOUND TO BOVINE THROMBIN EXPLAINS WHY THE MUTATION OF PHE-8 TO TYROSINE STRONGLY INHIBITS NORMAL CLEAVAGE AT ARGININE-16
5684:
5159:
8279:
7409:
6194:
6863:: THE REFINED 1.9 ANGSTROMS CRYSTAL STRUCTURE OF HUMAN ALPHA-THROMBIN: INTERACTION WITH D-PHE-PRO-ARG CHLOROMETHYLKETONE AND SIGNIFICANCE OF THE TYR-PRO-PRO-TRP INSERTION SEGMENT
6239:
5909:
5894:
7859:
7844:
7829:
3253:
Due to its high proteolytic specificity, thrombin is a valuable biochemical tool. The thrombin cleavage site (Leu-Val-Pro-Arg-Gly-Ser) is commonly included in linker regions of
6074:
6059:
2906:(Gla). In the presence of calcium, the Gla residues promote the binding of prothrombin to phospholipid bilayers. Deficiency of vitamin K or administration of the anticoagulant
4422:
Greenhalgh DG, Gamelli RL, Collins J, Sood R, Mozingo DW, Gray TE, Alexander WA (2009). "Recombinant thrombin: safety and immunogenicity in burn wound excision and grafting".
5984:
5864:
3490:
Royle NJ, Irwin DM, Koschinsky ML, MacGillivray RT, Hamerton JL (May 1987). "Human genes encoding prothrombin and ceruloplasmin map to 11p11-q12 and 3q21-24, respectively".
6089:
6839:
7049:
6809:
2976:
that catalyzes the formation of covalent bonds between lysine and glutamine residues in fibrin. The covalent bonds increase the stability of the fibrin clot. Thrombin
8219:
7574:
7559:
7169:
6104:
5369:
7274:
4081:
Degen SJ, McDowell SA, Sparks LM, Scharrer I (February 1995). "Prothrombin
Frankfurt: a dysfunctional prothrombin characterized by substitution of Glu-466 by Ala".
7739:
5444:
5339:
4249:
Borissoff JI, Heeneman S, Kilinç E, Kassák P, Van Oerle R, Winckers K, Govers-Riemslag JW, Hamulyák K, Hackeng TM, Daemen MJ, ten Cate H, Spronk HM (August 2010).
7814:
7799:
6944:
5669:
5654:
5639:
5624:
5939:
5354:
5174:
7724:
7334:
6209:
3330:. It can be useful for controlling minor bleeding from capillaries and small venules, but ineffective and not indicated for massive or brisk arterial bleeding.
7289:
6464:
6254:
5129:
5114:
3115:
There are an estimated 30 people in the world that have been diagnosed with the congenital form of Factor II deficiency, which should not be confused with the
7199:
7184:
9930:
8054:
6359:
3232:. Its presence indicates the existence of a clot. In 2013 a system for detecting the presence of thrombin was developed in mice. It combines peptide-coated
8859:
4699:
Howell DC, Laurent GJ, Chambers RC (April 2002). "Role of thrombin and its major cellular receptor, protease-activated receptor-1, in pulmonary fibrosis".
3158:
Activation of prothrombin is crucial in physiological and pathological coagulation. Various rare diseases involving prothrombin have been described (e.g.,
8144:
7139:
6869:
6824:
5504:
5489:
5474:
5099:
2491:
9790:
6344:
5759:
5534:
5519:
2472:
5459:
1627:
7094:
7079:
5879:
5774:
5189:
9530:
6329:
5234:
5144:
8084:
6494:
6224:
8350:
8309:
8294:
8069:
6479:
3122:
Prothrombin G20210A is not usually accompanied by other factor mutations (i.e., the most common is factor V Leiden). The gene may be inherited
7694:
6569:
7994:
7778:: 2.1 Angstrom structure of a nonproductive complex between antithrombin, synthetic heparin mimetic SR123781 and two S195A thrombin molecules
3472:
7064:
3454:
7619:
7604:
6974:
7589:
7019:
6509:
6449:
6434:
8742:
6158:: THE ISOMORPHOUS STRUCTURES OF PRETHROMBIN2, HIRUGEN-AND PPACK-THROMBIN: CHANGES ACCOMPANYING ACTIVATION AND EXOSITE BINDING TO THROMBIN
6143:: THE ISOMORPHOUS STRUCTURES OF PRETHROMBIN2, HIRUGEN-AND PPACK-THROMBIN: CHANGES ACCOMPANYING ACTIVATION AND EXOSITE BINDING TO THROMBIN
6128:: THE ISOMORPHOUS STRUCTURES OF PRETHROMBIN2, HIRUGEN-AND PPACK-THROMBIN: CHANGES ACCOMPANYING ACTIVATION AND EXOSITE BINDING TO THROMBIN
5249:
5019:
4604:
Lenting PJ, van Mourik JA, Mertens K (December 1998). "The life cycle of coagulation factor VIII in view of its structure and function".
7328:: THROMBIN COMPLEXED WITH FIBRINOPEPTIDE A ALPHA (RESIDUES 7-19). THREE COMPLEXES, ONE WITH EPSILON-THROMBIN AND TWO WITH ALPHA-THROMBIN
7124:
9094:
7634:
7109:
6689:
5849:
4973:
3821:"TAFI, or plasma procarboxypeptidase B, couples the coagulation and fibrinolytic cascades through the thrombin-thrombomodulin complex"
2695:
9407:
7649:
6524:
7979:
7964:
7664:
6959:
6593:: Design of weakly basic thrombin inhibitors incorporating novel P1 binding functions: molecular and X-ray crystallographic studies.
6323:: CRYSTAL STRUCTURE OF THE COMPLEX OF HUMAN ALPHA-THROMBIN AND NON-HYDROLYZABLE BIFUNCTIONAL INHIBITORS, HIRUTONIN-2 AND HIRUTONIN-6
6308:: CRYSTAL STRUCTURE OF THE COMPLEX OF HUMAN ALPHA-THROMBIN AND NON-HYDROLYZABLE BIFUNCTIONAL INHIBITORS, HIRUTONIN-2 AND HIRUTONIN-6
5603:: STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR
5588:: STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR
5573:: STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR
3358:
has stated that "there is danger of misleading the consumers since there is no way to tell this reconstituted meat from real meat".
2702:
8249:
5384:
7304:
6683:: CRYSTALLOGRAPHIC STRUCTURES OF THROMBIN COMPLEXED WITH THROMBIN RECEPTOR PEPTIDES: EXISTENCE OF EXPECTED AND NOVEL BINDING MODES
6668:: CRYSTALLOGRAPHIC STRUCTURES OF THROMBIN COMPLEXED WITH THROMBIN RECEPTOR PEPTIDES: EXISTENCE OF EXPECTED AND NOVEL BINDING MODES
6653:: CRYSTALLOGRAPHIC STRUCTURES OF THROMBIN COMPLEXED WITH THROMBIN RECEPTOR PEPTIDES: EXISTENCE OF EXPECTED AND NOVEL BINDING MODES
6638:: CRYSTALLOGRAPHIC STRUCTURES OF THROMBIN COMPLEXED WITH THROMBIN RECEPTOR PEPTIDES: EXISTENCE OF EXPECTED AND NOVEL BINDING MODES
6623:: CRYSTALLOGRAPHIC STRUCTURES OF THROMBIN COMPLEXED WITH THROMBIN RECEPTOR PEPTIDES: EXISTENCE OF EXPECTED AND NOVEL BINDING MODES
6608:: CRYSTALLOGRAPHIC STRUCTURES OF THROMBIN COMPLEXED WITH THROMBIN RECEPTOR PEPTIDES: EXISTENCE OF EXPECTED AND NOVEL BINDING MODES
5609:
5399:
5324:
5309:
5040:
9550:
7004:
6734:
5429:
8099:
7679:
5843:: CRYSTALLOGRAPHIC ANALYSIS AT 3.0-ANGSTROMS RESOLUTION OF THE BINDING TO HUMAN THROMBIN OF FOUR ACTIVE SITE-DIRECTED INHIBITORS
5828:: CRYSTALLOGRAPHIC ANALYSIS AT 3.0-ANGSTROMS RESOLUTION OF THE BINDING TO HUMAN THROMBIN OF FOUR ACTIVE SITE-DIRECTED INHIBITORS
5813:: CRYSTALLOGRAPHIC ANALYSIS AT 3.0-ANGSTROMS RESOLUTION OF THE BINDING TO HUMAN THROMBIN OF FOUR ACTIVE SITE-DIRECTED INHIBITORS
5798:: CRYSTALLOGRAPHIC ANALYSIS AT 3.0-ANGSTROMS RESOLUTION OF THE BINDING TO HUMAN THROMBIN OF FOUR ACTIVE SITE-DIRECTED INHIBITORS
4489:
3007:, an inhibitor of the coagulation cascade. The activation of protein C is greatly enhanced following the binding of thrombin to
8834:
7763:: Ternary complex of an orally active thrombin inhibitor with human thrombin and a c-terminal hirudin derived exo-sit inhibitor
7379:
4165:
Bernstein CN, Sargent M, Vos HL, Rosendaal FR (February 2007). "Mutations in clotting factors and inflammatory bowel disease".
7394:
5423:: THE STRUCTURE OF RESIDUES 7-16 OF THE A ALPHA CHAIN OF HUMAN FIBRINOGEN BOUND TO BOVINE THROMBIN AT 2.3 ANGSTROMS RESOLUTION
5288:: HUMAN ALPHA-THROMBIN TERNARY COMPLEX WITH THE EXOSITE INHIBITOR HIRUGEN AND ACTIVE SITE INHIBITOR PHCH2OCO-D-DPA-PRO-BOROMPG
10321:
10296:
6803:: Dissecting and Designing Inhibitor Selectivity Determinants at the S1 site Using an Artificial Ala190 Protease (Ala190 uPA)
5549:
5079:
7469:
6929:
6914:
6899:
6884:
3437:
8611:
5744:
5273:: CRYSTAL STRUCTURE OF HUMAN ALPHA-THROMBIN COMPLEXED WITH HIRUGEN AND P-AMIDINOPHENYLPYRUVATE) AT 1.6 ANGSTROMS RESOLUTION
4806:
De
Cristofaro R, De Candia E (June 2003). "Thrombin domains: structure, function and interaction with platelet receptors".
4633:
Plow EF, Cierniewski CS, Xiao Z, Haas TA, Byzova TV (July 2001). "AlphaIIbbeta3 and its antagonism at the new millennium".
54:
5303:: HUMAN ALPHA-THROMBIN TERNARY COMPLEX WITH EXOSITE INHIBITOR HIRUGEN AND ACTIVE SITE INHIBITOR PHCH2OCO-D-DPA-PRO-BOROVAL
5031:
9523:
8213:: Human thrombin chimera with human residues 184a, 186, 186a, 186b, 186c and 222 replaced by murine thrombin equivalents.
6284:
4520:"Thrombomodulin as a model of molecular mechanisms that modulate protease specificity and function at the vessel surface"
3416:
3236:
attached to "reporter chemicals". When a peptide binds to a thrombin molecule, the report is released and appears in the
8234:
7163:: HUMAN THROMBIN WITH ACTIVE SITE N-METHYL-D PHENYLALANYL-N--1- BUTYL]-L-PROLINAMIDE TRIFLUROACETATE AND EXOSITE-HIRUGEN
5924:
10316:
8343:
8189:
8174:
8159:
6788:: Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
6053:: A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE
6038:: A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE
6023:: A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE
6008:: A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE
6998:: Novel Non-Covalent Thrombin Inhibitors Incorporating P1 4,5,6,7-Tetrahydrobenzothiazole Arginine Side Chain Mimetics
5738:: INTERACTION OF FACTOR XIII ACTIVATION PEPTIDE WITH ALPHA-THROMBIN: CRYSTAL STRUCTURE OF THE ENZYME-SUBSTRATE COMPLEX
4563:"Time course of upregulation of inflammatory mediators in the hemorrhagic brain in rats: correlation with brain edema"
9995:
9508:
8737:
8659:
8654:
7253:: CHANGES IN INTERACTIONS IN COMPLEXES OF HIRUDIN DERIVATIVES AND HUMAN ALPHA-THROMBIN DUE TO DIFFERENT CRYSTAL FORMS
7238:: CHANGES IN INTERACTIONS IN COMPLEXES OF HIRUDIN DERIVATIVES AND HUMAN ALPHA-THROMBIN DUE TO DIFFERENT CRYSTAL FORMS
6719:
4948:
3612:
3355:
3209:, releasing thrombin. This can induce an acute and prolonged narrowing of the blood vessel, potentially resulting in
8788:
7034:
3342:, is sold under the brand name Fibrimex for use as a binding agent for meat. Both proteins in Fibrimex derives from
1791:
9016:
7259:
6749:
2910:
inhibits the production of gamma-carboxyglutamic acid residues, slowing the activation of the coagulation cascade.
2859:
6773:: Human Thrombin complexed with a d-Phe-Pro-Arg-type Inhibitor and a C-terminal Hirudin derived exo-site inhibitor
9325:
9280:
8616:
8452:
7454:
4468:
3441:
3420:
3277:
3257:
constructs. Following purification of the fusion protein, thrombin can be used to selectively cleave between the
1768:
8442:
8273:: THE CRYSTAL STRUCTURE OF ALPHA-THROMBIN-HIRUNORM IV COMPLEX REVEALS A NOVEL SPECIFICITY SITE RECOGNITION MODE.
8039:
7784:
7349:
6704:
9516:
9417:
9087:
8392:
8024:
8009:
2536:
8138:: STRUCTURES OF THE NONCOVALENT COMPLEXES OF HUMAN AND BOVINE PROTHROMBIN FRAGMENT 2 WITH HUMAN PPACK-THROMBIN
8123:: STRUCTURES OF THE NONCOVALENT COMPLEXES OF HUMAN AND BOVINE PROTHROMBIN FRAGMENT 2 WITH HUMAN PPACK-THROMBIN
6389:
6374:
5708:: STRUCTURE OF THROMBIN COMPLEXED WITH SELECTIVE NON-ELECTROPHILIC INHIBITORS HAVING CYCLOHEXYL MOIETIES AT P1
10306:
10151:
8887:
8692:
8336:
7439:
7424:
5723:: STRUCTURE OF THROMBIN COMPLEXED WITH SELECTIVE NON-ELECTOPHILIC INHIBITORS HAVING CYCLOHEXYL MOIETIES AT P1
2866:
1690:
1665:
7364:
6188:: COMPLEX OF HUMAN ALPHA-THROMBIN WITH A 15MER OLIGONUCLEOTIDE GGTTGGTGTGGTTGG (BASED ON X-RAY MODEL OF DNA)
4670:
Maragoudakis ME, Tsopanoglou NE, Andriopoulou P (April 2002). "Mechanism of thrombin-induced angiogenesis".
2517:
9750:
8644:
8497:
4835:
Tsopanoglou NE, Maragoudakis ME (February 2004). "Role of thrombin in angiogenesis and tumor progression".
4290:
Borissoff JI, Spronk HM, ten Cate H (May 2011). "The hemostatic system as a modulator of atherosclerosis".
3107:
appears to allosterically promote the active conformation of thrombin by inserting this N-terminal region.
1607:
10301:
7223:: MOLECULAR BASIS FOR THE INHIBITION OF HUMAN ALPHA-THROMBIN BY THE MACROCYCLIC PEPTIDE CYCLOTHEONAMIDE A
6173:: COMPLEX OF HUMAN ALPHA-THROMBIN WITH A 15MER OLIGONUCLEOTIDE GGTTGGTGTGGTTGG (BASED ON NMR MODEL OF DNA
2992:
2977:
7544:
7529:
7514:
7499:
6539:
6419:
6404:
5969:
5954:
5693:: CRYSTAL STRUCTURE OF HUMAN ALPHA THROMBIN IN COMPLEX WITH 5-AMIDINOINDOLE-4-BENZYLPIPERIDINE INHIBITOR
5228:: STRUCTURE OF THE HIRULOG 3-THROMBIN COMPLEX AND NATURE OF THE S' SUBSITES OF SUBSTRATES AND INHIBITORS
5213:: STRUCTURE OF THE HIRULOG 3-THROMBIN COMPLEX AND NATURE OF THE S' SUBSITES OF SUBSTRATES AND INHIBITORS
10266:
9212:
8864:
8827:
8288:: HIRUNORMS ARE TRUE HIRUDIN MIMETICS. THE CRYSTAL STRUCTURE OF HUMAN ALPHA-THROMBIN:HIRUNORM V COMPLEX
7418:: ALPHA-THROMBIN COMPLEX WITH SULFATED HIRUDIN (RESIDUES 54-65) AND L-ARGININE TEMPLATE INHIBITOR CS107
6554:
6203:: HUMAN ALPHA-THROMBIN COMPLEXED WITH A PEPTIDYL PYRIDINIUM METHYL KETONE CONTAINING BIVALENT INHIBITOR
5009:
3254:
3135:
2903:
6248:: THE STRUCTURE OF A NONADECAPEPTIDE OF THE FIFTH EGF DOMAIN OF THROMBOMODULIN COMPLEXED WITH THROMBIN
10252:
10239:
10226:
10213:
10200:
10187:
10174:
10136:
9665:
9650:
9373:
9080:
8732:
7868:: DESIGN AND DISCOVERY OF NOVEL, POTENT THROMBIN INHIBITORS WITH A SOLUBILIZING CATIONIC P1-P2-LINKER
7853:: DESIGN AND DISCOVERY OF NOVEL, POTENT THROMBIN INHIBITORS WITH A SOLUBILIZING CATIONIC P1-P2-LINKER
7838:: DESIGN AND DISCOVERY OF NOVEL, POTENT THROMBIN INHIBITORS WITH A SOLUBILIZING CATIONIC P1-P2-LINKER
5072:
3393:
3312:
3175:
1804:
1703:
6083:: SELECTIVITY AT S1, H2O DISPLACEMENT, UPA, TPA, SER190/ALA190 PROTEASE, STRUCTURE-BASED DRUG DESIGN
6068:: SELECTIVITY AT S1, H2O DISPLACEMENT, UPA, TPA, SER190/ALA190 PROTEASE, STRUCTURE-BASED DRUG DESIGN
5168:: CRYSTAL STRUCTURES OF THROMBIN WITH THIAZOLE-CONTAINING INHIBITORS: PROBES OF THE S1' BINDING SITE
1594:
10146:
10100:
10043:
9547:
9222:
2796:
2610:
1797:
1696:
1615:
10048:
9940:
9905:
9900:
9456:
9241:
8892:
7949:
7934:
7919:
7904:
7889:
7874:
5993:: CRYSTAL STRUCTURE OF HUMAN ALPHA-THROMBIN COMPLEXED WITH BCH-10556 AND EXOSITE-DIRECTED PEPTIDE
5873:: CRYSTAL STRUCTURE OF THE HUMAN ALPHA-THROMBIN-HAEMADIN COMPLEX: AN EXOSITE II-BINDING INHIBITOR
3198:
2678:
2657:
2631:
2606:
8869:
8558:
8554:
4326:
3019:
cells. Activated protein C inactivates factors Va and VIIIa. Binding of activated protein C to
2959:
8522:
6098:: X-RAY STRUCTURE OF THE HUMAN ALPHA-THROMBIN COMPLEX WITH A TRIPEPTIDE PHOSPHONATE INHIBITOR.
5918:: DESIGN OF P1' AND P3' RESIDUES OF TRIVALENT THROMBIN INHIBITORS AND THEIR CRYSTAL STRUCTURES
5903:: DESIGN OF P1' AND P3' RESIDUES OF TRIVALENT THROMBIN INHIBITORS AND THEIR CRYSTAL STRUCTURES
5054:
provides an overview of all the structure information available in the PDB for Mouse
Thrombin.
5048:
provides an overview of all the structure information available in the PDB for Human
Thrombin.
3533:
Degen SJ, Davie EW (September 1987). "Nucleotide sequence of the gene for human prothrombin".
2312:
positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway
10069:
9988:
9895:
9745:
9188:
9051:
8820:
8673:
8417:
8386:
8376:
6848:: CRYSTAL STRUCTURE OF THE COMPLEX OF PLATELET RECEPTOR GPIB-ALPHA AND ALPHA-THROMBIN AT 2.6A
6269:
2963:
2778:
1679:
7058:: crystal structure of Thrombin in complex with a potent P1 heterocycle-Aryl based inhibitor
10141:
9885:
6818:: Crystal Structure of the Complex of Platelet Receptor GPIb-alpha and Human alpha-Thrombin
5065:
4970:
3954:
Davie EW, Kulman JD (April 2006). "An overview of the structure and function of thrombin".
3179:
8714:
8228:: STRUCTURE OF HUMAN ALPHA-THROMBIN Y225F MUTANT BOUND TO D-PHE-PRO-ARG-CHLOROMETHYLKETONE
7718:: Crystal structure of the complex between thrombin and the central ""E"" region of fibrin
7583:: X-ray crystal structure of thrombin inhibited by synthetic cyanopeptide analogue RA-1014
7568:: X-ray crystal structure of thrombin inhibited by synthetic cyanopeptide analogue RA-1008
7178:: STRUCTURE OF HUMAN ALPHA-THROMBIN Y225P MUTANT BOUND TO D-PHE-PRO-ARG-CHLOROMETHYLKETONE
6113:: X-RAY CRYSTAL STRUCTURE OF HUMAN ALPHA-THROMBIN WITH A TRIPEPTIDE PHOSPHONATE INHIBITOR.
5378:: STRUCTURE OF HUMAN ALPHA-THROMBIN Y225I MUTANT BOUND TO D-PHE-PRO-ARG-CHLOROMETHYLKETONE
4471:[Sweden voted in favor of the meat paste] (in Swedish). Dagens Nyheter. 2010-02-09
3997:
Huber R, Bode W (1978-03-01). "Structural basis of the activation and action of trypsin".
3776:
Wolberg AS (September 2012). "Determinants of fibrin formation, structure, and function".
3119:
mutation, which is also called the factor II mutation. Prothrombin G20210A is congenital.
2950:
to XIIIa. In the conversion of fibrinogen into fibrin, thrombin catalyzes the cleavage of
8:
10105:
9785:
9775:
9592:
9587:
9475:
8724:
8701:
8682:
8664:
8359:
5022:
5013:
4819:
3388:
3281:
3171:
3159:
3116:
7283:: Crystal structure of the potent anticoagulant thrombin mutant W215A/E217A in free form
3735:
Andrew M, Paes B, Milner R, Johnston M, Mitchell L, Tollefsen DM, Powers P (July 1987).
3315:, a newer class of medication, directly inhibit thrombin by binding to its active site.
2882:
Thrombin is produced by the enzymatic cleavage of two sites on prothrombin by activated
1635:
10311:
10038:
9402:
9192:
8990:
8367:
7748:: orally active thrombin inhibitors in complex with thrombin and an exosite decapeptide
5453:: X-RAY STRUCTURE OF THE COMPLEX OF HUMAN ALPHA THROMBIN WITH THE INHIBITOR SDZ 229-357
5348:: THROMBIN INHIBITOR FROM THEONALLA, CYCLOTHEANAMIDE-BASED MACROCYCLIC TRIPEPTIDE MOTIF
4936:
4860:
4789:
4772:
4724:
4658:
4587:
4562:
4549:
4447:
4190:
4142:
4125:
4106:
4058:
4033:
3979:
3936:
3862:"Macromolecular specificity determinants on thrombin for fibrinogen and thrombomodulin"
3801:
3712:
3687:
3668:
3585:
3515:
3167:
3143:
3139:
3134:, such as oral contraceptives may be additive. The previously reported relationship of
1639:
9538:
7823:: HUMAN THROMBIN COMPLEXED WITH FRAGMENT-BASED SMALL MOLECULES OCCUPYING THE S1 POCKET
7808:: HUMAN THROMBIN COMPLEXED WITH FRAGMENT-BASED SMALL MOLECULES OCCUPYING THE S1 POCKET
6953:: HUMAN ALPHA-THROMBIN IN COMPLEX WITH BIVALENT, BENZAMIDINE-BASED SYNTHETIC INHIBITOR
5678:: CRYSTAL STRUCTURE OF HUMAN ALPHA THROMBIN IN COMPLEX WITH BENZOTHIOPHENE INHIBITOR 1
5663:: CRYSTAL STRUCTURE OF HUMAN ALPHA THROMBIN IN COMPLEX WITH BENZOTHIOPHENE INHIBITOR 2
5648:: CRYSTAL STRUCTURE OF HUMAN ALPHA-THROMBIN IN COMPLEX WITH BENZOTHIOPHENE INHIBITOR 3
5633:: CRYSTAL STRUCTURE OF HUMAN ALPHA THROMBIN IN COMPLEX WITH BENZOTHIOPHENE INHIBITOR 4
4400:
4364:
4267:
4250:
3878:
3861:
2894:
complex. Prothrombin is produced in the liver and is co-translationally modified in a
2862:
hypothesised the existence of an enzyme that converts fibrinogen into fibrin in 1872.
2406:
2401:
2396:
2391:
2386:
2381:
2376:
2371:
2366:
2361:
2356:
2351:
2346:
2341:
2336:
2331:
2326:
2321:
2316:
2311:
2306:
2301:
2296:
2291:
2286:
2281:
2276:
2271:
2266:
2261:
2256:
2251:
2246:
2241:
2236:
2231:
2226:
2221:
2216:
2211:
2195:
2190:
2185:
2180:
2175:
2170:
2165:
2160:
2155:
2139:
2134:
2129:
2124:
2119:
2114:
2109:
2104:
2099:
2094:
2089:
2084:
9767:
9446:
9196:
8752:
8709:
5948:: THE INTERACTION OF THROMBIN WITH FIBRINOGEN: A STRUCTURAL BASIS FOR ITS SPECIFICITY
5363:: HUMAN THROMBIN COMPLEXED WITH NOVEL SYNTHETIC PEPTIDE MIMETIC INHIBITOR AND HIRUGEN
5183:: HUMAN THROMBIN COMPLEXED WITH NOVEL SYNTHETIC PEPTIDE MIMETIC INHIBITOR AND HIRUGEN
5051:
5045:
4992:
4944:
4924:
4895:
4864:
4852:
4823:
4794:
4759:
4716:
4687:
4650:
4621:
4592:
4541:
4439:
4404:
4368:
4307:
4272:
4231:
4182:
4178:
4147:
4098:
4063:
4014:
3971:
3928:
3901:
3883:
3842:
3793:
3758:
3717:
3703:
3633:
3608:
3550:
3507:
3210:
3202:
1587:
47:
7733:: 1.9 angstrom crytal structure of wild-type human thrombin in the sodium free state
7343:: ALPHA-THROMBIN (HIRUGEN) COMPLEXED WITH NA-(N,N-DIMETHYLCARBAMOYL)-ALPHA-AZALYSINE
6218:: STRUCTURE OF A RETRO-BINDING PEPTIDE INHIBITOR COMPLEXED WITH HUMAN ALPHA-THROMBIN
4728:
4662:
4553:
4194:
4110:
3983:
3805:
3672:
3589:
3519:
10084:
10079:
10053:
9981:
9559:
9431:
9378:
9026:
8879:
8765:
8760:
7298:: Crystal structure of the anticoagulant thrombin mutant W215A/E217A bound to PPACK
6473:: HUMAN ALPHA-THROMBIN COMPLEXED WITH AC-(D)PHE-PRO-BORO-N-BUTYL-AMIDINO-GLYCINE-OH
6263:: THE STRUCTURE OF ALPHA-THROMBIN INHIBITED BY A 15-MER SINGLE-STRANDED DNA APTAMER
5138:: COMPLEX OF HUMAN ALPHA-THROMBIN WITH THE BIFUNCTIONAL BORONATE INHIBITOR BOROLOG2
5123:: COMPLEX OF HUMAN ALPHA-THROMBIN WITH THE BIFUNCTIONAL BORONATE INHIBITOR BOROLOG1
4916:
4885:
4844:
4815:
4784:
4749:
4708:
4679:
4642:
4613:
4582:
4574:
4531:
4451:
4431:
4396:
4360:
4299:
4262:
4221:
4174:
4137:
4090:
4053:
4045:
4006:
3963:
3940:
3920:
3873:
3832:
3785:
3748:
3707:
3699:
3660:
3577:
3542:
3499:
3319:
3266:
3052:
2973:
2955:
2951:
1884:
1815:
1759:
1714:
7208:: STRUCTURES OF THROMBIN COMPLEXES WITH A DESIGNED AND A NATURAL EXOSITE INHIBITOR
7193:: STRUCTURES OF THROMBIN COMPLEXES WITH A DESIGNED AND A NATURAL EXOSITE INHIBITOR
3603:
Kaushansky K, Lichtman M, Prchal J, Levi M, Press O, Burns L, Caligiuri M (2015).
1619:
10131:
10115:
10028:
9800:
9795:
9567:
9543:
9451:
9208:
9204:
9200:
9116:
9103:
9000:
8995:
8985:
8980:
8975:
8970:
8965:
8960:
8432:
8411:
8397:
8063:: Crystal structure of the slow form of thrombin in a self-inhibited conformation
6368:: CRYSTAL STRUCTURE OF THROMBIN IN COMPLEX WITH A NOVEL BICYCLIC LACTAM INHIBITOR
5035:
4983:
Kujovich JL (February 2021). Adam MP, Ardinger HH, Pagon RA, et al. (eds.).
4977:
4578:
4435:
3789:
3186:
3090:
3075:
2843:
1859:
1643:
4536:
4519:
4049:
3753:
3736:
3477:
National Center for
Biotechnology Information, U.S. National Library of Medicine
3459:
National Center for
Biotechnology Information, U.S. National Library of Medicine
3303:-dependent carboxylation of several coagulation factors, including prothrombin.
10280:
10169:
10110:
8950:
8945:
8940:
8935:
8930:
8925:
8920:
8915:
8910:
8770:
5028:
4920:
4890:
4873:
3688:"Chemical and functional aspects of posttranslational modification of proteins"
3104:
3067:
3008:
2981:
2891:
2782:
1960:
5003:
4617:
10290:
10074:
10033:
9945:
9818:
9807:
9539:
9351:
9346:
9304:
9146:
9061:
8851:
8583:
8507:
8462:
7148:: 2.5A Crystal Structure of the Antithrombin-Thrombin-Heparin Ternary Complex
6878:: CRYSTAL STRUCTURE OF THROMBIN COMPLEXED WITH AN GUANIDINE-MIMETIC INHIBITOR
6833:: COMPLEX OF RECOMBINANT HUMAN THROMBIN WITH A DESIGNED FLUORINATED INHIBITOR
4984:
4018:
3837:
3820:
3637:
3292:
2899:
2071:
5513:: RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES
5498:: RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES
5483:: RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES
5108:: STRUCTURE OF THROMBIN INHIBITED BY AERUGINOSIN298-A FROM A BLUE-GREEN ALGA
3023:
leads to a modest increase in its activity. Thrombin is also inactivated by
2886:(Xa). The activity of factor Xa is greatly enhanced by binding to activated
2387:
negative regulation of cytokine production involved in inflammatory response
2020:
1898:
10023:
9841:
9735:
9577:
9480:
9336:
9319:
9270:
9226:
9107:
9046:
8843:
8780:
8626:
8591:
6353:: Crystal Structure of Native S195A Thrombin with an Unoccupied Active Site
5768:: SER195ALA MUTANT OF HUMAN THROMBIN COMPLEXED WITH FIBRINOPEPTIDE A (7-16)
5543:: SELECTIVE NON ELECTROPHILIC THROMBIN INHIBITORS WITH CYCLOHEXYL MOIETIES.
5528:: SELECTIVE NON ELECTROPHILIC THROMBIN INHIBITORS WITH CYCLOHEXYL MOIETIES.
4996:
4928:
4899:
4856:
4827:
4798:
4763:
4720:
4691:
4654:
4646:
4596:
4443:
4408:
4372:
4311:
4276:
4235:
4186:
4151:
4126:"Cardiology patient pages. Prothrombin 20210 mutation (factor II mutation)"
4094:
4067:
3975:
3932:
3797:
3721:
3367:
3123:
3024:
2987:
As part of its activity in the coagulation cascade, thrombin also promotes
2969:
2914:
1877:
1656:
5468:: STRUCTURE OF THROMBIN COMPLEXED WITH BOVINE PANCREATIC TRYPSIN INHIBITOR
4848:
4625:
4545:
4303:
4102:
4034:"Thrombomodulin Binding Selects the Catalytically Active Form of Thrombin"
3967:
3887:
3846:
3762:
3568:
Schmidt A (1872). "Neue
Untersuchungen ueber die Fasserstoffesgerinnung".
3554:
3511:
2742:
2737:
10247:
10182:
10018:
9960:
9955:
9604:
9495:
9397:
9388:
9341:
9331:
9266:
9184:
9169:
9121:
9072:
9031:
8902:
8634:
8569:
8540:
8487:
8153:: Crystal structure of thrombin in complex with fibrinogen gamma' peptide
4754:
4737:
4226:
4209:
3372:
3099:
3094:
3016:
2947:
2931:
2774:
2581:
2562:
2042:
4907:
Wolberg AS (May 2007). "Thrombin generation and fibrin clot structure".
4561:
Wu H, Zhang Z, Li Y, Zhao R, Li H, Song Y, Qi J, Wang J (October 2010).
4010:
3546:
2799:
9922:
9864:
9645:
9640:
9620:
9440:
9392:
9314:
9309:
9299:
9261:
9237:
9036:
8550:
8512:
8472:
8467:
8457:
4771:
Minami T, Sugiyama A, Wu SQ, Abid R, Kodama T, Aird WC (January 2004).
4712:
4683:
3664:
3581:
3503:
3377:
3339:
3327:
3233:
3229:
3214:
3131:
3127:
3063:
3044:
2939:
2382:
antimicrobial humoral immune response mediated by antimicrobial peptide
1776:
1673:
1623:
8328:
7103:: Crystal Structure Analysis of a novel Oxyguanidine bound to Thrombin
7088:: Crystal Structure Analysis of a novel Oxyguanidine bound to Thrombin
5888:: COMPLEX STRUCTURE OF HUMAN THROMBIN WITH N-METHYL-ARGININE INHIBITOR
5783:: Crystal structure of human alpha-thrombin*RWJ-51438 complex at 1.7 A
5198:: THROMBIN COMPLEXED WITH A BETA-MIMETIC THIAZOLE-CONTAINING INHIBITOR
3905:
3318:
Recombinant thrombin is available as a powder for reconstitution into
2272:
positive regulation of release of sequestered calcium ion into cytosol
1564:
1560:
1556:
1552:
1548:
1544:
1540:
1536:
1532:
1528:
1524:
1520:
1516:
1512:
1508:
1504:
1500:
1496:
1492:
1488:
1484:
1480:
1476:
1472:
1468:
1464:
1460:
1456:
1452:
1448:
1444:
1440:
1436:
1432:
1428:
1424:
1420:
1416:
1412:
1408:
1404:
1400:
1396:
1392:
1388:
1384:
1380:
1376:
1372:
1368:
1364:
1360:
1356:
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1332:
1328:
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1320:
1316:
1312:
1308:
1304:
1300:
1296:
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1288:
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1280:
1276:
1272:
1268:
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1260:
1256:
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1196:
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1164:
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1148:
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1136:
1132:
1128:
1124:
1120:
1116:
1112:
1108:
1104:
1100:
1096:
1092:
1088:
1084:
1080:
1076:
1072:
1068:
1064:
1060:
1056:
1052:
1048:
1044:
1040:
1036:
1032:
1028:
1024:
1020:
1016:
1012:
1008:
1004:
1000:
996:
992:
988:
984:
980:
976:
972:
968:
964:
960:
956:
952:
948:
944:
940:
936:
932:
928:
924:
920:
916:
912:
908:
904:
900:
896:
892:
888:
884:
880:
876:
872:
868:
864:
860:
856:
852:
848:
844:
840:
836:
832:
828:
824:
820:
816:
812:
808:
804:
800:
796:
792:
788:
784:
780:
776:
772:
768:
764:
760:
756:
752:
748:
744:
740:
736:
732:
728:
724:
720:
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712:
708:
704:
700:
696:
692:
688:
684:
680:
676:
672:
668:
664:
660:
656:
652:
648:
644:
640:
636:
632:
628:
624:
620:
616:
612:
608:
604:
600:
596:
592:
588:
584:
580:
576:
572:
568:
564:
560:
556:
552:
548:
544:
540:
536:
532:
528:
524:
520:
516:
512:
508:
504:
500:
496:
492:
488:
484:
480:
476:
472:
468:
464:
460:
456:
452:
448:
444:
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436:
432:
428:
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420:
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412:
408:
404:
400:
396:
392:
388:
384:
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376:
372:
368:
364:
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356:
352:
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344:
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336:
332:
328:
324:
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316:
312:
308:
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296:
292:
288:
284:
280:
276:
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268:
264:
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236:
232:
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224:
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212:
208:
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196:
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156:
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144:
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136:
132:
128:
124:
120:
116:
112:
108:
104:
100:
96:
92:
88:
84:
80:
76:
10221:
10195:
9950:
9936:
9755:
9635:
9625:
9470:
9218:
9155:
9138:
9041:
8649:
8606:
8601:
8596:
8482:
8477:
6338:: Crystal Structure of the Heparin Cofactor II-S195A Thrombin Complex
5243:: COMPLEX OF THROMBIN WITH AND INHIBITOR CONTAINING A NOVEL P1 MOIETY
5153:: THROMBIN COMPLEXED WITH HIRUGEN AND A BETA-STRAND MIMETIC INHIBITOR
4738:"Cellular actions of the insulin-like growth factor binding proteins"
3737:"Development of the human coagulation system in the full-term infant"
3300:
3291:
Manipulation of prothrombin is central to the mode of action of most
3194:
3079:
3020:
3004:
2927:
2895:
2436:
1843:
1830:
1742:
1729:
1631:
8093:: STRUCTURE OF THE HIRUGEN AND HIRULOG 1 COMPLEXES OF ALPHA-THROMBIN
6503:: HUMAN ALPHA-THROMBIN COMPLEXED WITH AC-(D)PHE-PRO-BOROORNITHINE-OH
6233:: STRUCTURE OF THE HIRUGEN AND HIRULOG 1 COMPLEXES OF ALPHA-THROMBIN
10275:
9836:
9831:
9780:
9630:
9582:
9485:
9383:
9251:
8535:
8530:
8318:: CRYSTAL STRUCTURE OF HUMAN ALPHA-THROMBIN INHIBITED WITH SEL2770.
8303:: CRYSTAL STRUCTURE OF HUMAN ALPHA-THROMBIN INHIBITED WITH SEL2711.
8078:: Crystal structure of human alpha-thrombin in complex with suramin
6488:: HUMAN ALPHA-THROMBIN COMPLEXED WITH AC-(D)PHE-PRO-BORO-HOMOLYS-OH
4669:
4210:"Is thrombin a key player in the 'coagulation-atherogenesis' maze?"
4032:
Handley LD, Treuheit NA, Venkatesh VJ, Komives EA (November 2015).
3924:
3308:
3296:
3285:
3258:
3163:
3147:
3083:
2988:
2935:
2907:
2887:
2883:
2850:, as well as catalyzing many other coagulation-related reactions.
2754:
2726:
7703:: Orally Active Thrombin Inhibitors in Complex with Thrombin Inh12
6578:: thrombin in complex with selective macrocyclic inhibitor at 1.8A
9890:
9880:
9826:
9740:
9572:
8797:
8639:
8003:: COMPLEX OF RECOMBINANT HUMAN THROMBIN WITH A DESIGNED INHIBITOR
3382:
3343:
3323:
3304:
3262:
3190:
3071:
3056:
3012:
2548:
2503:
2421:
2417:
7073:: ANTITHROMBIN-ANHYDROTHROMBIN-HEPARIN TERNARY COMPLEX STRUCTURE
3489:
3269:
from the protein of interest with a high degree of specificity.
3240:
where it can be detected. Human testing has not been conducted.
2247:
positive regulation of reactive oxygen species metabolic process
1611:
10234:
10004:
9917:
9859:
9464:
8812:
8564:
8421:
7628:: Crystal structure of the thrombin mutant G193P bound to PPACK
7613:: Crystal structure of the thrombin mutant G193A bound to PPACK
6983:: Thrombin in complex with natural product inhibitor Oscillarin
4966:
4251:"Early atherosclerosis exhibits an enhanced procoagulant state"
4207:
4031:
3347:
3307:
increases the affinity of antithrombin to thrombin (as well as
3218:
3206:
3028:
2943:
2847:
2710:
2458:
2051:
7598:: thrombin and P2 pyridine N-oxide inhibitor complex structure
7028:: Crystal structure of the anticoagulant slow form of thrombin
6518:: Crystal structure of the anticoagulant slow form of thrombin
6458:: HUMAN ALPHA-THROMBIN COMPLEXED WITH AC-(D)PHE-PRO-BOROLYS-OH
6443:: HUMAN ALPHA-THROMBIN COMPLEXED WITH AC-(D)PHE-PRO-BOROARG-OH
5057:
2402:
positive regulation of receptor signaling pathway via JAK-STAT
2222:
positive regulation of phosphatidylinositol 3-kinase signaling
10208:
9926:
9912:
9851:
9725:
9720:
9715:
9710:
9705:
9700:
9021:
8955:
8612:
Protein Z-related protease inhibitor (ZPI) (inhibits FX, FXI)
8406:
8401:
5258:: HUMAN ALPHA-THROMBIN INHIBITION BY EOC-D-PHE-PRO-AZALYS-ONP
4248:
4208:
Borissoff JI, Spronk HM, Heeneman S, ten Cate H (June 2009).
3237:
7133:: Crystal structure of thrombin in complex with compound 14b
4421:
4385:
4164:
3602:
3051:
The molecular weight of prothrombin is approximately 72,000
3043:
Anchoring of bovine prothrombin to the membrane through its
9695:
9690:
9685:
9680:
9675:
9670:
9660:
9655:
8426:
4080:
3685:
3039:
2926:
In the blood coagulation pathway, thrombin acts to convert
9973:
7643:: thrombin in complex with an oxazolopyridine inhibitor 21
7118:: Crystal structure of thrombin in complex with compound 1
6698:: thrombin in complex with selective macrocyclic inhibitor
5858:: CRYSTAL STRUCTURE OF THE THROMBIN-THROMBOMODULIN COMPLEX
7658:: Thrombin in complex with an oxazolopyridine inhibitor 2
6533:: Crystal Structure of Thrombin in Complex with L-378,622
3686:
Knorre DG, Kudryashova NV, Godovikova TS (October 2009).
2252:
endoplasmic reticulum to Golgi vesicle-mediated transport
7988:: COMPLEX OF RECOMBINANT HUMAN THROMBIN WITH A INHIBITOR
7973:: COMPLEX OF RECOMBINANT HUMAN THROMBIN WITH A INHIBITOR
7673:: Thrombin in complex with an azafluorenyl inhibitor 23b
6968:: 2.5A Structure of Anticoagulant Thrombin Variant E217K
4603:
4349:
3734:
3265:
residues of the cleavage site, effectively removing the
1867:
8258:: THE REFINED STRUCTURE OF THE HIRUDIN-THROMBIN COMPLEX
5393:: THROMBIN INHIBITOR WITH A RIGID TRIPEPTIDYL ALDEHYDES
4834:
4773:"Thrombin and phenotypic modulation of the endothelium"
4632:
4289:
3062:
Prothrombin is composed of four domains; an N-terminal
30:
8617:
Tissue factor pathway inhibitor (TFPI) (inhibits FIII)
7313:: Crystal structure of the thrombin mutant D221A/D222K
5618:: THROMBIN INHIBITORS WITH RIGID TRIPEPTIDYL ALDEHYDES
5408:: THROMBIN INHIBITORS WITH RIGID TRIPEPTIDYL ALDEHYDES
5333:: NOVEL COVALENT THROMBIN INHIBITOR FROM PLANT EXTRACT
5318:: NOVEL COVALENT THROMBIN INHIBITOR FROM PLANT EXTRACT
4805:
3910:
2367:
positive regulation of protein localization to nucleus
10264:
7013:: Fast form of thrombin mutant R(77a)A bound to PPACK
6743:: Human alpha thrombin inhibited by RPPGF and hirugen
5438:: ALPHA-THROMBIN COMPLEXED WITH HIRUGEN AND PROFLAVIN
4969:
online database for peptidases and their inhibitors:
4698:
2846:, that converts fibrinogen into strands of insoluble
2032:
8860:
Branched-chain alpha-keto acid dehydrogenase complex
8108:: CRYSTALLOGRAPHIC STRUCTURE OF HUMAN GAMMA-THROMBIN
7688:: Structure of thrombin in 400 mM potassium chloride
4939:(1995). "Prothrombin". In High K, Roberts H (eds.).
4770:
3150:
Leiden mutation have been contradicted by research.
2277:
positive regulation of cell population proliferation
2227:
positive regulation of collagen biosynthetic process
1598:, PT, RPRGL2, THPH1, coagulation factor II, thrombin
7388:: Specificity for Plasminogen Activator Inhibitor-1
3818:
3651:Morawitz P (1905). "Die Chemie der Blutgerinnung".
3632:. Philadelphia: Lea and Febiger. pp. 451–490.
8683:Thrombin-activatable fibrinolysis inhibitor (TAFI)
7403:: COMPLEX OF THROMBIN WITH DESIGNED INHIBITOR 7165
4777:Arteriosclerosis, Thrombosis, and Vascular Biology
3433:
3431:
3429:
3412:
3410:
3408:
8743:Activated protein C–protein C inhibitor (APC–PCI)
5558:: SELECTIVE NON-ELECTROPHILIC THROMBIN INHIBITORS
4991:. Seattle WA: University of Washington, Seattle.
2758:Role of thrombin in the blood coagulation cascade
2297:regulation of cytosolic calcium ion concentration
1814:
1713:
10288:
7478:: Crystal structure of thrombin bound to heparin
6938:: NOVEL COVALENT ACTIVE SITE THROMBIN INHIBITORS
6923:: NOVEL COVALENT ACTIVE SITE THROMBIN INHIBITORS
6908:: NOVEL COVALENT ACTIVE SITE THROMBIN INHIBITORS
6893:: NOVEL COVALENT ACTIVE SITE THROMBIN INHIBITORS
2858:After the description of fibrinogen and fibrin,
2337:negative regulation of astrocyte differentiation
8592:Antithrombin (inhibits FII, FIX, FX, FXI, FXII)
5753:: COMPLEX OF A DIVALENT INHIBITOR WITH THROMBIN
3426:
3405:
3859:
3438:GRCm38: Ensembl release 89: ENSMUSG00000027249
2966:chains of fibrinogen to form fibrin monomers.
2342:positive regulation of protein phosphorylation
16:Enzyme involved in blood coagulation in humans
9989:
9524:
9088:
8828:
8344:
6293:: HUMAN THROMBIN COMPLEX WITH HIRUDIN VARIANT
5073:
4874:"Structure and interaction modes of thrombin"
4560:
2991:activation and aggregation via activation of
8243:: ACTIVE SITE MIMETIC INHIBITION OF THROMBIN
5933:: ACTIVE SITE MIMETIC INHIBITION OF THROMBIN
4941:Molecular Basis of Thrombosis and Hemostasis
4482:
4415:
4379:
4343:
4283:
4242:
4201:
4117:
3894:
3769:
3679:
3228:Thrombin is implicated in the physiology of
2397:G protein-coupled receptor signaling pathway
2372:positive regulation of lipid kinase activity
8198:: HUMAN THROMBIN HIRUGEN INHIBITOR COMPLEX.
8183:: HUMAN THROMBIN HIRUGEN INHIBITOR COMPLEX.
8168:: HUMAN THROMBIN HIRUGEN INHIBITOR COMPLEX.
4735:
4389:Journal of the American College of Surgeons
4353:Journal of the American College of Surgeons
4074:
3953:
3853:
3819:Bajzar L, Morser J, Nesheim M (July 1996).
3812:
3570:Pflügers Archiv für die gesamte Physiologie
3417:GRCh38: Ensembl release 89: ENSG00000180210
3003:Thrombin bound to thrombomodulin activates
2913:In human adults, the normal blood level of
9996:
9982:
9531:
9517:
9102:
9095:
9081:
8835:
8821:
8351:
8337:
5080:
5066:
3532:
3526:
3483:
2332:negative regulation of platelet activation
9408:Tetragalacturonic acid hydroxymethylester
8660:Plasminogen activator inhibitor-2 (PAI-2)
8655:Plasminogen activator inhibitor-1 (PAI-1)
6728:: Staphylocoagulase-Prethrombin-2 complex
4889:
4788:
4753:
4586:
4535:
4324:
4266:
4225:
4141:
4123:
4057:
3996:
3877:
3836:
3752:
3711:
3567:
2392:regulation of signaling receptor activity
1975:fetal liver hematopoietic progenitor cell
7043:: Slow form of Thrombin Bound with PPACK
5029:Thrombin: RCSB PDB Molecule of the Month
4982:
4167:The American Journal of Gastroenterology
3650:
3170:may be a factor in the formation of the
3038:
2898:-dependent reaction that converts 10-12
2753:
2407:blood coagulation, fibrin clot formation
2292:positive regulation of blood coagulation
2196:collagen-containing extracellular matrix
8358:
7268:: ALPHA-THROMBIN COMPLEXED WITH HIRUGEN
6758:: D-Phe-Pro-Arg-Type Thrombin Inhibitor
4906:
3775:
3272:
3182:can be caused by the G20210A mutation.
2262:cell surface receptor signaling pathway
10289:
9544:serine proteases/serine endopeptidases
8453:High-molecular-weight kininogen (HMWK)
4808:Journal of Thrombosis and Thrombolysis
2995:on the cell membrane of the platelet.
2921:
9977:
9512:
9076:
8816:
8332:
7463:: Nonbasic Thrombin Inhibitor Complex
5061:
4935:
4878:Blood Cells, Molecules & Diseases
4837:Seminars in Thrombosis and Hemostasis
4736:Firth SM, Baxter RC (December 2002).
4517:
4469:"Sverige röstade ja till köttklister"
4463:
4461:
3956:Seminars in Thrombosis and Hemostasis
3627:
3193:, is implicated as a major factor in
2902:in the N terminus of the molecule to
2828:activated blood-coagulation factor II
1819:
1780:
1775:
1718:
1677:
1672:
8048:: Thrombin in complex with inhibitor
7793:: thrombin in complex with inhibitor
7358:: BOVINE THROMBIN--BM51.1011 COMPLEX
6713:: Staphylocoagulase-Thrombin Complex
4871:
3860:Jakubowski HV, Owen WG (July 1989).
2998:
2237:peptidyl-glutamic acid carboxylation
2212:blood coagulation, intrinsic pathway
8738:Thrombin–antithrombin complex (TAT)
8033:: Orally active thrombin inhibitors
8018:: orally active thrombin inhibitors
4424:Journal of Burn Care & Research
4327:"Nanomedicine: Particle physiology"
4292:The New England Journal of Medicine
3866:The Journal of Biological Chemistry
3825:The Journal of Biological Chemistry
3492:Somatic Cell and Molecular Genetics
2377:regulation of complement activation
2287:negative regulation of fibrinolysis
13:
8645:Tissue plasminogen activator (tPA)
8602:Protein S (cofactor for protein C)
6398:: HUMAN THROMBIN-INHIBITOR COMPLEX
6383:: HUMAN THROMBIN-INHIBITOR COMPLEX
4820:10.1023/B:THRO.0000011370.80989.7b
4790:10.1161/01.ATV.0000099880.09014.7D
4510:
4458:
4143:10.1161/01.CIR.0000135582.53444.87
3333:
3153:
2785:enzyme complex to form thrombin.
2327:negative regulation of proteolysis
2257:positive regulation of cell growth
2232:multicellular organism development
2125:serine-type endopeptidase activity
14:
10333:
9283:(II, VII, IX, X, protein C and S)
7448:: ACTIVE SITE THROMBIN INHIBITORS
7433:: ACTIVE SITE THROMBIN INHIBITORS
4959:
4401:10.1016/j.jamcollsurg.2009.03.016
4365:10.1016/j.jamcollsurg.2007.03.020
4268:10.1161/CIRCULATIONAHA.109.907121
3354:General secretary Jan Bertoft of
2769:) is encoded in the human by the
10274:
8842:
8308:
8293:
8278:
8263:
8248:
8233:
8218:
8203:
8188:
8173:
8158:
8143:
8128:
8113:
8098:
8083:
8068:
8053:
8038:
8023:
8008:
7993:
7978:
7963:
7948:
7933:
7918:
7903:
7888:
7873:
7858:
7843:
7828:
7813:
7798:
7783:
7768:
7753:
7738:
7723:
7708:
7693:
7678:
7663:
7648:
7633:
7618:
7603:
7588:
7573:
7558:
7543:
7528:
7513:
7498:
7483:
7468:
7453:
7438:
7423:
7408:
7393:
7378:
7373:: THROMBIN:HIRUDIN 51-65 COMPLEX
7363:
7348:
7333:
7318:
7303:
7288:
7273:
7258:
7243:
7228:
7213:
7198:
7183:
7168:
7153:
7138:
7123:
7108:
7093:
7078:
7063:
7048:
7033:
7018:
7003:
6988:
6973:
6958:
6943:
6928:
6913:
6898:
6883:
6868:
6853:
6838:
6823:
6808:
6793:
6778:
6763:
6748:
6733:
6718:
6703:
6688:
6673:
6658:
6643:
6628:
6613:
6598:
6583:
6568:
6553:
6538:
6523:
6508:
6493:
6478:
6463:
6448:
6433:
6418:
6403:
6388:
6373:
6358:
6343:
6328:
6313:
6298:
6283:
6268:
6253:
6238:
6223:
6208:
6193:
6178:
6163:
6148:
6133:
6118:
6103:
6088:
6073:
6058:
6043:
6028:
6013:
5998:
5983:
5968:
5953:
5938:
5923:
5908:
5893:
5878:
5863:
5848:
5833:
5818:
5803:
5788:
5773:
5758:
5743:
5728:
5713:
5698:
5683:
5668:
5653:
5638:
5623:
5608:
5593:
5578:
5563:
5548:
5533:
5518:
5503:
5488:
5473:
5458:
5443:
5428:
5413:
5398:
5383:
5368:
5353:
5338:
5323:
5308:
5293:
5278:
5263:
5248:
5233:
5218:
5203:
5188:
5173:
5158:
5143:
5128:
5113:
5098:
5005:Anti-coagulation & proteases
4701:Biochemical Society Transactions
4672:Biochemical Society Transactions
4179:10.1111/j.1572-0241.2006.00974.x
3704:10.32607/20758251-2009-1-3-29-51
3248:
2191:external side of plasma membrane
2115:thrombospondin receptor activity
2041:
1803:
1796:
1790:
1767:
1702:
1695:
1689:
1664:
29:
9326:thrombopoietin receptor agonist
9281:Prothrombin complex concentrate
8733:Prothrombin fragment 1+2 (F1+2)
8393:Platelet membrane glycoproteins
5087:
4318:
4158:
4025:
3990:
3947:
3728:
3644:
3278:Prothrombin complex concentrate
3243:
3126:(1 pair), or much more rarely,
2217:regulation of blood coagulation
9418:Hemostatic Powder Spray TC-325
8597:Protein C (inhibits FV, FVIII)
4124:Varga EA, Moll S (July 2004).
3621:
3596:
3561:
3465:
3447:
3356:Swedish Consumers' Association
2865:Prothrombin was discovered by
2110:serine-type peptidase activity
2052:More reference expression data
2021:More reference expression data
1929:right hemisphere of cerebellum
1:
9756:Urinary plasminogen activator
4943:. Marcel Dekker. p. 75.
3999:Accounts of Chemical Research
3879:10.1016/S0021-9258(18)60437-5
3607:. McGraw-Hill. p. 1918.
3399:
3326:during surgery, as an aid to
3146:) and prothrombin G20210A or
2872:
2267:regulation of gene expression
1788:
1687:
10322:Peripheral membrane proteins
10297:Genes on human chromosome 11
9751:Tissue plasminogen activator
7553:: Thrombin Inhibitor Complex
7538:: Thrombin Inhibitor Complex
7523:: Thrombin Inhibitor Complex
7508:: Thrombin Inhibitor Complex
6548:: thrombin-hirugen_l-378,650
6428:: Thrombin inhibitor complex
6413:: Thrombin Inhibitor Complex
5978:: THROMBIN INHIBITOR COMPLEX
5963:: THROMBIN INHIBITOR COMPLEX
4579:10.1016/j.neuint.2010.06.002
4567:Neurochemistry International
4436:10.1097/BCR.0b013e3181a28979
3790:10.1097/MOH.0b013e32835673c2
3034:
2993:protease-activated receptors
2877:
7:
10003:
8473:Factor XII (Hageman factor)
8387:von Willebrand factor (vWF)
6563:: Thrombin-Hirugen-L405,426
4985:"Prothrombin Thrombophilia"
4537:10.1096/fasebj.9.10.7615164
4050:10.1021/acs.biochem.5b00825
3754:10.1182/blood.V70.1.165.165
3361:
2166:endoplasmic reticulum lumen
10:
10338:
9213:Valoctocogene roxaparvovec
8888:Epidermal transglutaminase
8865:Oxoglutarate dehydrogenase
8793:-antiplasmin complex (PAP)
8508:Factor III (tissue factor)
4921:10.1016/j.blre.2006.11.001
4891:10.1016/j.bcmd.2005.12.027
4635:Thrombosis and Haemostasis
4083:Thrombosis and Haemostasis
3313:direct thrombin inhibitors
3299:and related drugs inhibit
3255:recombinant fusion protein
3136:inflammatory bowel disease
2904:gamma-carboxyglutamic acid
2853:
2130:lipopolysaccharide binding
2090:signaling receptor binding
1991:sexually immature organism
10317:Drugs developed by Pfizer
10160:
10152:Michaelis–Menten kinetics
10124:
10093:
10062:
10011:
9873:
9850:
9842:Proteinase 3/Myeloblastin
9816:
9766:
9603:
9558:
9430:
9374:Absorbable gelatin sponge
9366:
9290:
9168:
9137:
9130:
9115:
9009:
8901:
8878:
8850:
8779:
8751:
8723:
8700:
8691:
8625:
8582:
8521:
8496:
8441:
8375:
8366:
5093:
4618:10.1182/blood.V92.11.3983
3913:Nature Structural Biology
3473:"Mouse PubMed Reference:"
3455:"Human PubMed Reference:"
3394:Thrombin generation assay
3176:antiphospholipid syndrome
3029:serine protease inhibitor
2741:
2736:
2732:
2725:
2709:
2690:
2675:
2671:
2654:
2650:
2643:
2628:
2624:
2603:
2599:
2592:
2579:
2575:
2560:
2556:
2547:
2534:
2530:
2515:
2511:
2502:
2489:
2485:
2470:
2466:
2457:
2442:
2435:
2431:
2415:
2307:signal peptide processing
2140:enzyme activator activity
2070:
2066:
2049:
2040:
2031:
2018:
1967:
1958:
1905:
1896:
1866:
1858:
1854:
1837:
1824:
1787:
1766:
1757:
1753:
1736:
1723:
1686:
1663:
1654:
1650:
1605:
1602:
1592:
1585:
1580:
73:
68:
51:
46:
41:
37:
28:
23:
10044:Diffusion-limited enzyme
9223:Fidanacogene elaparvovec
9042:Filaggrin (Citrullinate)
8715:β-Thromboglobulin (β-TG)
4325:Economist (2013-11-05).
3838:10.1074/jbc.271.28.16603
3338:Thrombin, combined with
3205:clots around a cerebral
3201:. Blood from a ruptured
2696:Chr 11: 46.72 – 46.74 Mb
2317:regulation of cell shape
9457:Aminomethylbenzoic acid
8893:Tissue transglutaminase
8710:Platelet factor 4 (PF4)
8607:Protein Z (inhibits FX)
8541:Prothrombin (factor II)
4214:Cardiovascular Research
3199:subarachnoid hemorrhage
3110:
3089:As is the case for all
3011:, an integral membrane
2703:Chr 2: 91.46 – 91.47 Mb
9896:Proprotein convertases
9017:Acetylcholine receptor
8870:Pyruvate dehydrogenase
8766:Fibrinopeptide B (FpB)
8761:Fibrinopeptide A (FpA)
8433:Glycoprotein VI (GPVI)
8398:Glycoprotein Ib (GPIb)
4647:10.1055/s-0037-1616198
4518:Esmon CT (July 1995).
4095:10.1055/s-0038-1653751
3048:
2759:
2105:growth factor activity
10137:Eadie–Hofstee diagram
10070:Allosteric regulation
9746:Plasminogen activator
9189:Damoctocog alfa pegol
9052:Sp100 nuclear antigen
8584:Anticoagulant factors
8551:Fibrinogen (factor I)
8546:Thrombin (factor IIa)
8418:Glycoprotein IIb/IIIa
8412:Glycoprotein IX (GP9)
8379:(platelet activation)
7958:: THROMBIN INHIBITORS
7943:: THROMBIN INHIBITORS
7928:: THROMBIN INHIBITORS
7913:: THROMBIN INHIBITORS
7898:: THROMBIN INHIBITORS
7883:: THROMBIN INHIBITORS
5041:Prothrombin Structure
4849:10.1055/s-2004-822971
4490:"Welcome to Fibrimex"
4304:10.1056/NEJMra1011670
3968:10.1055/s-2006-939550
3042:
2767:Coagulation factor II
2757:
2156:extracellular exosome
1925:cerebellar hemisphere
1680:Chromosome 11 (human)
10307:Acute-phase proteins
10147:Lineweaver–Burk plot
9886:Prolyl endopeptidase
8771:Fibrin monomers (FM)
8627:Fibrinolytic factors
8445:(contact activation)
4755:10.1210/er.2001-0033
3630:Hemorrhagic Diseases
3322:. It can be applied
3273:Medicine and surgery
3180:Hyperprothrombinemia
3162:). Anti-prothrombin
2958:from the respective
2302:response to wounding
2242:acute-phase response
2181:extracellular region
1821:2 E1|2 50.63 cM
1782:Chromosome 2 (mouse)
69:List of PDB id codes
42:Available structures
8725:Thrombin generation
8702:Platelet activation
8693:Coagulation markers
8368:Coagulation factors
8360:Coagulation cascade
5023:The Proteolysis Map
5014:The Proteolysis Map
4011:10.1021/ar50123a006
3605:Williams Hematology
3547:10.1021/bi00393a033
3389:The Proteolysis Map
3282:fresh frozen plasma
3185:Thrombin, a potent
3172:lupus anticoagulant
3160:hypoprothrombinemia
3117:prothrombin G20210A
3103:active fragment of
2922:Mechanism of action
2777:cleaved during the
2362:platelet activation
2282:leukocyte migration
2186:extracellular space
2161:blood microparticle
2085:calcium ion binding
1909:right lobe of liver
10302:Coagulation system
10106:Enzyme superfamily
10039:Enzyme promiscuity
9403:Oxidized cellulose
9193:Efanesoctocog alfa
8565:Fibrin (factor Ia)
8377:Primary hemostasis
5034:2013-10-05 at the
4976:2019-09-19 at the
4713:10.1042/BST0300211
4684:10.1042/BST0300173
4227:10.1093/cvr/cvp066
3665:10.1007/BF02321003
3582:10.1007/BF01612263
3504:10.1007/BF01535211
3168:autoimmune disease
3144:ulcerative colitis
3049:
2760:
2537:ENSMUSG00000027249
2205:Biological process
2149:Cellular component
2100:hydrolase activity
2095:peptidase activity
2078:Molecular function
1971:left lobe of liver
10262:
10261:
9971:
9970:
9768:Complement system
9560:Digestive enzymes
9506:
9505:
9476:Alfa1 antitrypsin
9447:Aminocaproic acid
9432:Antifibrinolytics
9426:
9425:
9362:
9361:
9197:Efmoroctocog alfa
9147:Phytomenadione (K
9070:
9069:
8810:
8809:
8806:
8805:
8753:Fibrin generation
8578:
8577:
8498:Extrinsic pathway
8443:Intrinsic pathway
8326:
8325:
6278:: SERINE PROTEASE
4742:Endocrine Reviews
3962:(Suppl 1): 3–15.
3778:Curr Opin Hematol
3628:Quick AJ (1957).
3211:cerebral ischemia
3203:cerebral aneurysm
3070:and a C-terminal
2999:Negative feedback
2952:fibrinopeptides A
2890:(Va), termed the
2860:Alexander Schmidt
2752:
2751:
2748:
2747:
2721:
2720:
2686:
2685:
2665:
2664:
2639:
2638:
2618:
2617:
2588:
2587:
2569:
2568:
2543:
2542:
2524:
2523:
2498:
2497:
2479:
2478:
2427:
2426:
2352:blood coagulation
2062:
2061:
2058:
2057:
2027:
2026:
2014:
2013:
1952:
1951:
1850:
1849:
1749:
1748:
1576:
1575:
1572:
1571:
52:Ortholog search:
10329:
10279:
10278:
10270:
10142:Hanes–Woolf plot
10085:Enzyme activator
10080:Enzyme inhibitor
10054:Enzyme catalysis
9998:
9991:
9984:
9975:
9974:
9533:
9526:
9519:
9510:
9509:
9379:Calcium alginate
9135:
9134:
9128:
9127:
9117:Antihemorrhagics
9104:Antihemorrhagics
9097:
9090:
9083:
9074:
9073:
9027:Apolipoprotein H
8880:Transglutaminase
8837:
8830:
8823:
8814:
8813:
8698:
8697:
8373:
8372:
8353:
8346:
8339:
8330:
8329:
8312:
8297:
8282:
8267:
8252:
8237:
8222:
8207:
8192:
8177:
8162:
8147:
8132:
8117:
8102:
8087:
8072:
8057:
8042:
8027:
8012:
7997:
7982:
7967:
7952:
7937:
7922:
7907:
7892:
7877:
7862:
7847:
7832:
7817:
7802:
7787:
7772:
7757:
7742:
7727:
7712:
7697:
7682:
7667:
7652:
7637:
7622:
7607:
7592:
7577:
7562:
7547:
7532:
7517:
7502:
7487:
7472:
7457:
7442:
7427:
7412:
7397:
7382:
7367:
7352:
7337:
7322:
7307:
7292:
7277:
7262:
7247:
7232:
7217:
7202:
7187:
7172:
7157:
7142:
7127:
7112:
7097:
7082:
7067:
7052:
7037:
7022:
7007:
6992:
6977:
6962:
6947:
6932:
6917:
6902:
6887:
6872:
6857:
6842:
6827:
6812:
6797:
6782:
6767:
6752:
6737:
6722:
6707:
6692:
6677:
6662:
6647:
6632:
6617:
6602:
6587:
6572:
6557:
6542:
6527:
6512:
6497:
6482:
6467:
6452:
6437:
6422:
6407:
6392:
6377:
6362:
6347:
6332:
6317:
6302:
6287:
6272:
6257:
6242:
6227:
6212:
6197:
6182:
6167:
6152:
6137:
6122:
6107:
6092:
6077:
6062:
6047:
6032:
6017:
6002:
5987:
5972:
5957:
5942:
5927:
5912:
5897:
5882:
5867:
5852:
5837:
5822:
5807:
5792:
5777:
5762:
5747:
5732:
5717:
5702:
5687:
5672:
5657:
5642:
5627:
5612:
5597:
5582:
5567:
5552:
5537:
5522:
5507:
5492:
5477:
5462:
5447:
5432:
5417:
5402:
5387:
5372:
5357:
5342:
5327:
5312:
5297:
5282:
5267:
5252:
5237:
5222:
5207:
5192:
5177:
5162:
5147:
5132:
5117:
5102:
5082:
5075:
5068:
5059:
5058:
5006:
5000:
4954:
4932:
4903:
4893:
4868:
4831:
4802:
4792:
4767:
4757:
4732:
4695:
4666:
4629:
4600:
4590:
4557:
4539:
4505:
4504:
4502:
4501:
4494:Fibrimex website
4486:
4480:
4479:
4477:
4476:
4465:
4456:
4455:
4419:
4413:
4412:
4383:
4377:
4376:
4347:
4341:
4340:
4338:
4337:
4322:
4316:
4315:
4287:
4281:
4280:
4270:
4246:
4240:
4239:
4229:
4205:
4199:
4198:
4162:
4156:
4155:
4145:
4121:
4115:
4114:
4078:
4072:
4071:
4061:
4029:
4023:
4022:
3994:
3988:
3987:
3951:
3945:
3944:
3908:
3898:
3892:
3891:
3881:
3872:(19): 11117–21.
3857:
3851:
3850:
3840:
3816:
3810:
3809:
3773:
3767:
3766:
3756:
3732:
3726:
3725:
3715:
3683:
3677:
3676:
3648:
3642:
3641:
3625:
3619:
3618:
3600:
3594:
3593:
3565:
3559:
3558:
3530:
3524:
3523:
3487:
3481:
3480:
3469:
3463:
3462:
3451:
3445:
3435:
3424:
3414:
3320:aqueous solution
3267:purification tag
3091:serine proteases
2974:transglutaminase
2779:clotting process
2734:
2733:
2705:
2698:
2681:
2669:
2668:
2660:
2648:
2647:
2644:RefSeq (protein)
2634:
2622:
2621:
2613:
2597:
2596:
2573:
2572:
2554:
2553:
2528:
2527:
2509:
2508:
2483:
2482:
2464:
2463:
2433:
2432:
2068:
2067:
2054:
2045:
2038:
2037:
2023:
2003:secondary oocyte
1963:
1961:Top expressed in
1956:
1955:
1933:popliteal artery
1921:secondary oocyte
1901:
1899:Top expressed in
1894:
1893:
1873:
1872:
1856:
1855:
1846:
1833:
1822:
1807:
1800:
1794:
1783:
1771:
1755:
1754:
1745:
1732:
1721:
1706:
1699:
1693:
1682:
1668:
1652:
1651:
1646:
1597:
1590:
1567:
66:
65:
60:
39:
38:
33:
21:
20:
10337:
10336:
10332:
10331:
10330:
10328:
10327:
10326:
10287:
10286:
10285:
10273:
10265:
10263:
10258:
10170:Oxidoreductases
10156:
10132:Enzyme kinetics
10120:
10116:List of enzymes
10089:
10058:
10029:Catalytic triad
10007:
10002:
9972:
9967:
9869:
9846:
9812:
9762:
9599:
9568:Enteropeptidase
9554:
9537:
9507:
9502:
9452:Tranexamic acid
9422:
9358:
9292:
9286:
9209:Turoctocog alfa
9205:Susoctocog alfa
9201:Moroctocog alfa
9171:
9164:
9159:
9150:
9119:
9111:
9101:
9071:
9066:
9005:
8897:
8874:
8846:
8841:
8811:
8802:
8792:
8775:
8747:
8719:
8687:
8677:
8668:
8621:
8574:
8517:
8500:(tissue factor)
8499:
8492:
8444:
8437:
8378:
8362:
8357:
8327:
8322:
8319:
8313:
8304:
8298:
8289:
8283:
8274:
8268:
8259:
8253:
8244:
8238:
8229:
8223:
8214:
8208:
8199:
8193:
8184:
8178:
8169:
8163:
8154:
8148:
8139:
8133:
8124:
8118:
8109:
8103:
8094:
8088:
8079:
8073:
8064:
8058:
8049:
8043:
8034:
8028:
8019:
8013:
8004:
7998:
7989:
7983:
7974:
7968:
7959:
7953:
7944:
7938:
7929:
7923:
7914:
7908:
7899:
7893:
7884:
7878:
7869:
7863:
7854:
7848:
7839:
7833:
7824:
7818:
7809:
7803:
7794:
7788:
7779:
7773:
7764:
7758:
7749:
7743:
7734:
7728:
7719:
7713:
7704:
7698:
7689:
7683:
7674:
7668:
7659:
7653:
7644:
7638:
7629:
7623:
7614:
7608:
7599:
7593:
7584:
7578:
7569:
7563:
7554:
7548:
7539:
7533:
7524:
7518:
7509:
7503:
7494:
7488:
7479:
7473:
7464:
7458:
7449:
7443:
7434:
7428:
7419:
7413:
7404:
7398:
7389:
7383:
7374:
7368:
7359:
7353:
7344:
7338:
7329:
7323:
7314:
7308:
7299:
7293:
7284:
7278:
7269:
7263:
7254:
7248:
7239:
7233:
7224:
7218:
7209:
7203:
7194:
7188:
7179:
7173:
7164:
7158:
7149:
7143:
7134:
7128:
7119:
7113:
7104:
7098:
7089:
7083:
7074:
7068:
7059:
7053:
7044:
7038:
7029:
7023:
7014:
7008:
6999:
6993:
6984:
6978:
6969:
6963:
6954:
6948:
6939:
6933:
6924:
6918:
6909:
6903:
6894:
6888:
6879:
6873:
6864:
6858:
6849:
6843:
6834:
6828:
6819:
6813:
6804:
6798:
6789:
6783:
6774:
6768:
6759:
6753:
6744:
6738:
6729:
6723:
6714:
6708:
6699:
6693:
6684:
6678:
6669:
6663:
6654:
6648:
6639:
6633:
6624:
6618:
6609:
6603:
6594:
6588:
6579:
6573:
6564:
6558:
6549:
6543:
6534:
6528:
6519:
6513:
6504:
6498:
6489:
6483:
6474:
6468:
6459:
6453:
6444:
6438:
6429:
6423:
6414:
6408:
6399:
6393:
6384:
6378:
6369:
6363:
6354:
6348:
6339:
6333:
6324:
6318:
6309:
6303:
6294:
6288:
6279:
6273:
6264:
6258:
6249:
6243:
6234:
6228:
6219:
6213:
6204:
6198:
6189:
6183:
6174:
6168:
6159:
6153:
6144:
6138:
6129:
6123:
6114:
6108:
6099:
6093:
6084:
6078:
6069:
6063:
6054:
6048:
6039:
6033:
6024:
6018:
6009:
6003:
5994:
5988:
5979:
5973:
5964:
5958:
5949:
5943:
5934:
5928:
5919:
5913:
5904:
5898:
5889:
5883:
5874:
5868:
5859:
5853:
5844:
5838:
5829:
5823:
5814:
5808:
5799:
5793:
5784:
5778:
5769:
5763:
5754:
5748:
5739:
5733:
5724:
5718:
5709:
5703:
5694:
5688:
5679:
5673:
5664:
5658:
5649:
5643:
5634:
5628:
5619:
5613:
5604:
5598:
5589:
5583:
5574:
5568:
5559:
5553:
5544:
5538:
5529:
5523:
5514:
5508:
5499:
5493:
5484:
5478:
5469:
5463:
5454:
5448:
5439:
5433:
5424:
5418:
5409:
5403:
5394:
5388:
5379:
5373:
5364:
5358:
5349:
5343:
5334:
5328:
5319:
5313:
5304:
5298:
5289:
5283:
5274:
5268:
5259:
5253:
5244:
5238:
5229:
5223:
5214:
5208:
5199:
5193:
5184:
5178:
5169:
5163:
5154:
5148:
5139:
5133:
5124:
5118:
5109:
5103:
5089:
5086:
5036:Wayback Machine
5004:
4978:Wayback Machine
4962:
4957:
4951:
4872:Bode W (2007).
4612:(11): 3983–96.
4513:
4511:Further reading
4508:
4499:
4497:
4488:
4487:
4483:
4474:
4472:
4467:
4466:
4459:
4420:
4416:
4384:
4380:
4348:
4344:
4335:
4333:
4323:
4319:
4298:(18): 1746–60.
4288:
4284:
4247:
4243:
4206:
4202:
4163:
4159:
4122:
4118:
4079:
4075:
4030:
4026:
3995:
3991:
3952:
3948:
3900:
3899:
3895:
3858:
3854:
3831:(28): 16603–8.
3817:
3813:
3774:
3770:
3733:
3729:
3684:
3680:
3649:
3645:
3626:
3622:
3615:
3601:
3597:
3566:
3562:
3541:(19): 6165–77.
3531:
3527:
3488:
3484:
3471:
3470:
3466:
3453:
3452:
3448:
3436:
3427:
3415:
3406:
3402:
3364:
3336:
3334:Food production
3275:
3251:
3246:
3187:vasoconstrictor
3174:(also known as
3156:
3154:Role in disease
3140:Crohn's disease
3113:
3076:serine protease
3068:kringle domains
3037:
3001:
2924:
2880:
2875:
2856:
2844:serine protease
2775:proteolytically
2743:View/Edit Mouse
2738:View/Edit Human
2701:
2694:
2691:Location (UCSC)
2677:
2656:
2630:
2609:
2605:
2518:ENSG00000180210
2411:
2200:
2176:plasma membrane
2144:
2135:heparin binding
2120:protein binding
2050:
2019:
2010:
2005:
2001:
1997:
1993:
1989:
1985:
1981:
1977:
1973:
1959:
1948:
1943:
1939:
1937:tibial arteries
1935:
1931:
1927:
1923:
1919:
1915:
1911:
1897:
1841:
1828:
1820:
1810:
1809:
1808:
1801:
1781:
1758:Gene location (
1740:
1727:
1719:
1709:
1708:
1707:
1700:
1678:
1655:Gene location (
1606:
1593:
1586:
75:
53:
17:
12:
11:
5:
10335:
10325:
10324:
10319:
10314:
10309:
10304:
10299:
10284:
10283:
10260:
10259:
10257:
10256:
10243:
10230:
10217:
10204:
10191:
10178:
10164:
10162:
10158:
10157:
10155:
10154:
10149:
10144:
10139:
10134:
10128:
10126:
10122:
10121:
10119:
10118:
10113:
10108:
10103:
10097:
10095:
10094:Classification
10091:
10090:
10088:
10087:
10082:
10077:
10072:
10066:
10064:
10060:
10059:
10057:
10056:
10051:
10046:
10041:
10036:
10031:
10026:
10021:
10015:
10013:
10009:
10008:
10001:
10000:
9993:
9986:
9978:
9969:
9968:
9966:
9965:
9964:
9963:
9958:
9948:
9943:
9934:
9920:
9915:
9910:
9909:
9908:
9903:
9893:
9888:
9883:
9877:
9875:
9871:
9870:
9868:
9867:
9862:
9856:
9854:
9848:
9847:
9845:
9844:
9839:
9834:
9829:
9823:
9821:
9814:
9813:
9811:
9810:
9805:
9804:
9803:
9798:
9788:
9783:
9778:
9772:
9770:
9764:
9763:
9761:
9760:
9759:
9758:
9753:
9743:
9731:
9730:
9729:
9728:
9723:
9718:
9713:
9708:
9703:
9698:
9693:
9688:
9683:
9678:
9673:
9668:
9663:
9658:
9653:
9643:
9638:
9633:
9628:
9623:
9618:
9609:
9607:
9601:
9600:
9598:
9597:
9596:
9595:
9590:
9580:
9575:
9570:
9564:
9562:
9556:
9555:
9540:Endopeptidases
9536:
9535:
9528:
9521:
9513:
9504:
9503:
9501:
9500:
9499:
9498:
9490:
9489:
9488:
9483:
9478:
9473:
9461:
9460:
9459:
9454:
9449:
9436:
9434:
9428:
9427:
9424:
9423:
9421:
9420:
9415:
9410:
9405:
9400:
9395:
9386:
9381:
9376:
9370:
9368:
9364:
9363:
9360:
9359:
9357:
9356:
9355:
9354:
9349:
9344:
9339:
9334:
9322:
9317:
9312:
9307:
9302:
9296:
9294:
9288:
9287:
9285:
9284:
9274:
9273:
9264:
9259:
9254:
9245:
9244:
9231:
9230:
9216:
9182:
9176:
9174:
9166:
9165:
9163:
9162:
9157:
9153:
9148:
9143:
9141:
9132:
9125:
9113:
9112:
9100:
9099:
9092:
9085:
9077:
9068:
9067:
9065:
9064:
9059:
9054:
9049:
9044:
9039:
9034:
9029:
9024:
9019:
9013:
9011:
9007:
9006:
9004:
9003:
8998:
8993:
8988:
8983:
8978:
8973:
8968:
8963:
8958:
8953:
8948:
8943:
8938:
8933:
8928:
8923:
8918:
8913:
8907:
8905:
8899:
8898:
8896:
8895:
8890:
8884:
8882:
8876:
8875:
8873:
8872:
8867:
8862:
8856:
8854:
8848:
8847:
8840:
8839:
8832:
8825:
8817:
8808:
8807:
8804:
8803:
8801:
8800:
8795:
8790:
8785:
8783:
8777:
8776:
8774:
8773:
8768:
8763:
8757:
8755:
8749:
8748:
8746:
8745:
8740:
8735:
8729:
8727:
8721:
8720:
8718:
8717:
8712:
8706:
8704:
8695:
8689:
8688:
8686:
8685:
8680:
8678:-Macroglobulin
8675:
8671:
8666:
8662:
8657:
8652:
8647:
8642:
8637:
8631:
8629:
8623:
8622:
8620:
8619:
8614:
8609:
8604:
8599:
8594:
8588:
8586:
8580:
8579:
8576:
8575:
8573:
8572:
8567:
8562:
8548:
8543:
8538:
8533:
8527:
8525:
8523:Common pathway
8519:
8518:
8516:
8515:
8510:
8504:
8502:
8494:
8493:
8491:
8490:
8485:
8480:
8475:
8470:
8465:
8460:
8455:
8449:
8447:
8439:
8438:
8436:
8435:
8430:
8424:
8415:
8409:
8404:
8389:
8383:
8381:
8370:
8364:
8363:
8356:
8355:
8348:
8341:
8333:
8324:
8323:
8321:
8320:
8314:
8307:
8305:
8299:
8292:
8290:
8284:
8277:
8275:
8269:
8262:
8260:
8254:
8247:
8245:
8239:
8232:
8230:
8224:
8217:
8215:
8209:
8202:
8200:
8194:
8187:
8185:
8179:
8172:
8170:
8164:
8157:
8155:
8149:
8142:
8140:
8134:
8127:
8125:
8119:
8112:
8110:
8104:
8097:
8095:
8089:
8082:
8080:
8074:
8067:
8065:
8059:
8052:
8050:
8044:
8037:
8035:
8029:
8022:
8020:
8014:
8007:
8005:
7999:
7992:
7990:
7984:
7977:
7975:
7969:
7962:
7960:
7954:
7947:
7945:
7939:
7932:
7930:
7924:
7917:
7915:
7909:
7902:
7900:
7894:
7887:
7885:
7879:
7872:
7870:
7864:
7857:
7855:
7849:
7842:
7840:
7834:
7827:
7825:
7819:
7812:
7810:
7804:
7797:
7795:
7789:
7782:
7780:
7774:
7767:
7765:
7759:
7752:
7750:
7744:
7737:
7735:
7729:
7722:
7720:
7714:
7707:
7705:
7699:
7692:
7690:
7684:
7677:
7675:
7669:
7662:
7660:
7654:
7647:
7645:
7639:
7632:
7630:
7624:
7617:
7615:
7609:
7602:
7600:
7594:
7587:
7585:
7579:
7572:
7570:
7564:
7557:
7555:
7549:
7542:
7540:
7534:
7527:
7525:
7519:
7512:
7510:
7504:
7497:
7495:
7489:
7482:
7480:
7474:
7467:
7465:
7459:
7452:
7450:
7444:
7437:
7435:
7429:
7422:
7420:
7414:
7407:
7405:
7399:
7392:
7390:
7384:
7377:
7375:
7369:
7362:
7360:
7354:
7347:
7345:
7339:
7332:
7330:
7324:
7317:
7315:
7309:
7302:
7300:
7294:
7287:
7285:
7279:
7272:
7270:
7264:
7257:
7255:
7249:
7242:
7240:
7234:
7227:
7225:
7219:
7212:
7210:
7204:
7197:
7195:
7189:
7182:
7180:
7174:
7167:
7165:
7159:
7152:
7150:
7144:
7137:
7135:
7129:
7122:
7120:
7114:
7107:
7105:
7099:
7092:
7090:
7084:
7077:
7075:
7069:
7062:
7060:
7054:
7047:
7045:
7039:
7032:
7030:
7024:
7017:
7015:
7009:
7002:
7000:
6994:
6987:
6985:
6979:
6972:
6970:
6964:
6957:
6955:
6949:
6942:
6940:
6934:
6927:
6925:
6919:
6912:
6910:
6904:
6897:
6895:
6889:
6882:
6880:
6874:
6867:
6865:
6859:
6852:
6850:
6844:
6837:
6835:
6829:
6822:
6820:
6814:
6807:
6805:
6799:
6792:
6790:
6784:
6777:
6775:
6769:
6762:
6760:
6754:
6747:
6745:
6739:
6732:
6730:
6724:
6717:
6715:
6709:
6702:
6700:
6694:
6687:
6685:
6679:
6672:
6670:
6664:
6657:
6655:
6649:
6642:
6640:
6634:
6627:
6625:
6619:
6612:
6610:
6604:
6597:
6595:
6589:
6582:
6580:
6574:
6567:
6565:
6559:
6552:
6550:
6544:
6537:
6535:
6529:
6522:
6520:
6514:
6507:
6505:
6499:
6492:
6490:
6484:
6477:
6475:
6469:
6462:
6460:
6454:
6447:
6445:
6439:
6432:
6430:
6424:
6417:
6415:
6409:
6402:
6400:
6394:
6387:
6385:
6379:
6372:
6370:
6364:
6357:
6355:
6349:
6342:
6340:
6334:
6327:
6325:
6319:
6312:
6310:
6304:
6297:
6295:
6289:
6282:
6280:
6274:
6267:
6265:
6259:
6252:
6250:
6244:
6237:
6235:
6229:
6222:
6220:
6214:
6207:
6205:
6199:
6192:
6190:
6184:
6177:
6175:
6169:
6162:
6160:
6154:
6147:
6145:
6139:
6132:
6130:
6124:
6117:
6115:
6109:
6102:
6100:
6094:
6087:
6085:
6079:
6072:
6070:
6064:
6057:
6055:
6049:
6042:
6040:
6034:
6027:
6025:
6019:
6012:
6010:
6004:
5997:
5995:
5989:
5982:
5980:
5974:
5967:
5965:
5959:
5952:
5950:
5944:
5937:
5935:
5929:
5922:
5920:
5914:
5907:
5905:
5899:
5892:
5890:
5884:
5877:
5875:
5869:
5862:
5860:
5854:
5847:
5845:
5839:
5832:
5830:
5824:
5817:
5815:
5809:
5802:
5800:
5794:
5787:
5785:
5779:
5772:
5770:
5764:
5757:
5755:
5749:
5742:
5740:
5734:
5727:
5725:
5719:
5712:
5710:
5704:
5697:
5695:
5689:
5682:
5680:
5674:
5667:
5665:
5659:
5652:
5650:
5644:
5637:
5635:
5629:
5622:
5620:
5614:
5607:
5605:
5599:
5592:
5590:
5584:
5577:
5575:
5569:
5562:
5560:
5554:
5547:
5545:
5539:
5532:
5530:
5524:
5517:
5515:
5509:
5502:
5500:
5494:
5487:
5485:
5479:
5472:
5470:
5464:
5457:
5455:
5449:
5442:
5440:
5434:
5427:
5425:
5419:
5412:
5410:
5404:
5397:
5395:
5389:
5382:
5380:
5374:
5367:
5365:
5359:
5352:
5350:
5344:
5337:
5335:
5329:
5322:
5320:
5314:
5307:
5305:
5299:
5292:
5290:
5284:
5277:
5275:
5269:
5262:
5260:
5254:
5247:
5245:
5239:
5232:
5230:
5224:
5217:
5215:
5209:
5202:
5200:
5194:
5187:
5185:
5179:
5172:
5170:
5164:
5157:
5155:
5149:
5142:
5140:
5134:
5127:
5125:
5119:
5112:
5110:
5104:
5097:
5094:
5091:
5090:
5085:
5084:
5077:
5070:
5062:
5056:
5055:
5049:
5043:
5038:
5026:
5017:
5001:
4980:
4961:
4960:External links
4958:
4956:
4955:
4949:
4933:
4904:
4869:
4832:
4803:
4768:
4733:
4696:
4667:
4630:
4601:
4558:
4530:(10): 946–55.
4514:
4512:
4509:
4507:
4506:
4481:
4457:
4414:
4378:
4342:
4317:
4282:
4241:
4220:(3): 392–403.
4200:
4157:
4116:
4073:
4044:(43): 6650–8.
4024:
4005:(3): 114–122.
3989:
3946:
3925:10.1038/nsb971
3893:
3852:
3811:
3768:
3727:
3678:
3643:
3620:
3613:
3595:
3560:
3525:
3482:
3464:
3446:
3425:
3403:
3401:
3398:
3397:
3396:
3391:
3386:
3380:
3375:
3370:
3363:
3360:
3335:
3332:
3293:anticoagulants
3274:
3271:
3250:
3247:
3245:
3242:
3155:
3152:
3112:
3109:
3105:thrombomodulin
3059:of proteases.
3036:
3033:
3009:thrombomodulin
3000:
2997:
2982:thrombomodulin
2923:
2920:
2900:glutamic acids
2892:prothrombinase
2879:
2876:
2874:
2871:
2855:
2852:
2840:gamma-thrombin
2783:prothrombinase
2750:
2749:
2746:
2745:
2740:
2730:
2729:
2723:
2722:
2719:
2718:
2716:
2714:
2707:
2706:
2699:
2692:
2688:
2687:
2684:
2683:
2673:
2672:
2666:
2663:
2662:
2652:
2651:
2645:
2641:
2640:
2637:
2636:
2626:
2625:
2619:
2616:
2615:
2601:
2600:
2594:
2590:
2589:
2586:
2585:
2577:
2576:
2570:
2567:
2566:
2558:
2557:
2551:
2545:
2544:
2541:
2540:
2532:
2531:
2525:
2522:
2521:
2513:
2512:
2506:
2500:
2499:
2496:
2495:
2487:
2486:
2480:
2477:
2476:
2468:
2467:
2461:
2455:
2454:
2449:
2444:
2440:
2439:
2429:
2428:
2425:
2424:
2413:
2412:
2410:
2409:
2404:
2399:
2394:
2389:
2384:
2379:
2374:
2369:
2364:
2359:
2354:
2349:
2344:
2339:
2334:
2329:
2324:
2319:
2314:
2309:
2304:
2299:
2294:
2289:
2284:
2279:
2274:
2269:
2264:
2259:
2254:
2249:
2244:
2239:
2234:
2229:
2224:
2219:
2214:
2208:
2206:
2202:
2201:
2199:
2198:
2193:
2188:
2183:
2178:
2173:
2168:
2163:
2158:
2152:
2150:
2146:
2145:
2143:
2142:
2137:
2132:
2127:
2122:
2117:
2112:
2107:
2102:
2097:
2092:
2087:
2081:
2079:
2075:
2074:
2064:
2063:
2060:
2059:
2056:
2055:
2047:
2046:
2035:
2029:
2028:
2025:
2024:
2016:
2015:
2012:
2011:
2009:
2008:
2004:
2000:
1999:primary oocyte
1996:
1992:
1988:
1984:
1980:
1976:
1972:
1968:
1965:
1964:
1953:
1950:
1949:
1947:
1946:
1942:
1938:
1934:
1930:
1926:
1922:
1918:
1914:
1910:
1906:
1903:
1902:
1890:
1889:
1881:
1870:
1864:
1863:
1860:RNA expression
1852:
1851:
1848:
1847:
1839:
1835:
1834:
1826:
1823:
1818:
1812:
1811:
1802:
1795:
1789:
1785:
1784:
1779:
1773:
1772:
1764:
1763:
1751:
1750:
1747:
1746:
1738:
1734:
1733:
1725:
1722:
1717:
1711:
1710:
1701:
1694:
1688:
1684:
1683:
1676:
1670:
1669:
1661:
1660:
1648:
1647:
1644:F2 - orthologs
1604:
1600:
1599:
1591:
1583:
1582:
1578:
1577:
1574:
1573:
1570:
1569:
71:
70:
62:
61:
50:
44:
43:
35:
34:
26:
25:
15:
9:
6:
4:
3:
2:
10334:
10323:
10320:
10318:
10315:
10313:
10310:
10308:
10305:
10303:
10300:
10298:
10295:
10294:
10292:
10282:
10277:
10272:
10271:
10268:
10254:
10250:
10249:
10244:
10241:
10237:
10236:
10231:
10228:
10224:
10223:
10218:
10215:
10211:
10210:
10205:
10202:
10198:
10197:
10192:
10189:
10185:
10184:
10179:
10176:
10172:
10171:
10166:
10165:
10163:
10159:
10153:
10150:
10148:
10145:
10143:
10140:
10138:
10135:
10133:
10130:
10129:
10127:
10123:
10117:
10114:
10112:
10111:Enzyme family
10109:
10107:
10104:
10102:
10099:
10098:
10096:
10092:
10086:
10083:
10081:
10078:
10076:
10075:Cooperativity
10073:
10071:
10068:
10067:
10065:
10061:
10055:
10052:
10050:
10047:
10045:
10042:
10040:
10037:
10035:
10034:Oxyanion hole
10032:
10030:
10027:
10025:
10022:
10020:
10017:
10016:
10014:
10010:
10006:
9999:
9994:
9992:
9987:
9985:
9980:
9979:
9976:
9962:
9959:
9957:
9954:
9953:
9952:
9949:
9947:
9946:Streptokinase
9944:
9942:
9938:
9935:
9932:
9928:
9924:
9921:
9919:
9916:
9914:
9911:
9907:
9904:
9902:
9899:
9898:
9897:
9894:
9892:
9889:
9887:
9884:
9882:
9879:
9878:
9876:
9872:
9866:
9863:
9861:
9858:
9857:
9855:
9853:
9849:
9843:
9840:
9838:
9835:
9833:
9830:
9828:
9825:
9824:
9822:
9820:
9819:immune system
9815:
9809:
9808:C3-convertase
9806:
9802:
9799:
9797:
9794:
9793:
9792:
9789:
9787:
9784:
9782:
9779:
9777:
9774:
9773:
9771:
9769:
9765:
9757:
9754:
9752:
9749:
9748:
9747:
9744:
9742:
9739:
9737:
9733:
9732:
9727:
9724:
9722:
9719:
9717:
9714:
9712:
9709:
9707:
9704:
9702:
9699:
9697:
9694:
9692:
9689:
9687:
9684:
9682:
9679:
9677:
9674:
9672:
9669:
9667:
9664:
9662:
9659:
9657:
9654:
9652:
9649:
9648:
9647:
9644:
9642:
9639:
9637:
9634:
9632:
9629:
9627:
9624:
9622:
9619:
9617:
9614:
9611:
9610:
9608:
9606:
9602:
9594:
9591:
9589:
9586:
9585:
9584:
9581:
9579:
9576:
9574:
9571:
9569:
9566:
9565:
9563:
9561:
9557:
9552:
9549:
9545:
9541:
9534:
9529:
9527:
9522:
9520:
9515:
9514:
9511:
9497:
9494:
9493:
9491:
9487:
9484:
9482:
9479:
9477:
9474:
9472:
9469:
9468:
9467:
9466:
9462:
9458:
9455:
9453:
9450:
9448:
9445:
9444:
9443:
9442:
9438:
9437:
9435:
9433:
9429:
9419:
9416:
9414:
9411:
9409:
9406:
9404:
9401:
9399:
9396:
9394:
9390:
9387:
9385:
9382:
9380:
9377:
9375:
9372:
9371:
9369:
9365:
9353:
9352:Rafutrombopag
9350:
9348:
9347:Lusutrombopag
9345:
9343:
9340:
9338:
9335:
9333:
9330:
9329:
9328:
9327:
9323:
9321:
9318:
9316:
9313:
9311:
9308:
9306:
9305:Carbazochrome
9303:
9301:
9298:
9297:
9295:
9289:
9282:
9279:
9278:combinations:
9276:
9275:
9272:
9268:
9265:
9263:
9260:
9258:
9255:
9253:
9250:
9247:
9246:
9243:
9239:
9236:
9233:
9232:
9228:
9224:
9220:
9217:
9214:
9210:
9206:
9202:
9198:
9194:
9190:
9186:
9183:
9181:
9178:
9177:
9175:
9173:
9167:
9161:
9154:
9152:
9145:
9144:
9142:
9140:
9136:
9133:
9129:
9126:
9123:
9118:
9114:
9109:
9105:
9098:
9093:
9091:
9086:
9084:
9079:
9078:
9075:
9063:
9062:Topoisomerase
9060:
9058:
9055:
9053:
9050:
9048:
9045:
9043:
9040:
9038:
9035:
9033:
9030:
9028:
9025:
9023:
9020:
9018:
9015:
9014:
9012:
9008:
9002:
8999:
8997:
8994:
8992:
8989:
8987:
8984:
8982:
8979:
8977:
8974:
8972:
8969:
8967:
8964:
8962:
8959:
8957:
8954:
8952:
8949:
8947:
8944:
8942:
8939:
8937:
8934:
8932:
8929:
8927:
8924:
8922:
8919:
8917:
8914:
8912:
8909:
8908:
8906:
8904:
8900:
8894:
8891:
8889:
8886:
8885:
8883:
8881:
8877:
8871:
8868:
8866:
8863:
8861:
8858:
8857:
8855:
8853:
8852:Dehydrogenase
8849:
8845:
8838:
8833:
8831:
8826:
8824:
8819:
8818:
8815:
8799:
8796:
8794:
8787:
8786:
8784:
8782:
8778:
8772:
8769:
8767:
8764:
8762:
8759:
8758:
8756:
8754:
8750:
8744:
8741:
8739:
8736:
8734:
8731:
8730:
8728:
8726:
8722:
8716:
8713:
8711:
8708:
8707:
8705:
8703:
8699:
8696:
8694:
8690:
8684:
8681:
8679:
8672:
8670:
8663:
8661:
8658:
8656:
8653:
8651:
8648:
8646:
8643:
8641:
8638:
8636:
8633:
8632:
8630:
8628:
8624:
8618:
8615:
8613:
8610:
8608:
8605:
8603:
8600:
8598:
8595:
8593:
8590:
8589:
8587:
8585:
8581:
8571:
8568:
8566:
8563:
8560:
8556:
8552:
8549:
8547:
8544:
8542:
8539:
8537:
8534:
8532:
8529:
8528:
8526:
8524:
8520:
8514:
8511:
8509:
8506:
8505:
8503:
8501:
8495:
8489:
8486:
8484:
8481:
8479:
8476:
8474:
8471:
8469:
8466:
8464:
8463:Prekallikrein
8461:
8459:
8456:
8454:
8451:
8450:
8448:
8446:
8440:
8434:
8431:
8428:
8425:
8423:
8419:
8416:
8413:
8410:
8408:
8405:
8403:
8399:
8396:
8394:
8390:
8388:
8385:
8384:
8382:
8380:
8374:
8371:
8369:
8365:
8361:
8354:
8349:
8347:
8342:
8340:
8335:
8334:
8331:
8317:
8311:
8306:
8302:
8296:
8291:
8287:
8281:
8276:
8272:
8266:
8261:
8257:
8251:
8246:
8242:
8236:
8231:
8227:
8221:
8216:
8212:
8206:
8201:
8197:
8191:
8186:
8182:
8176:
8171:
8167:
8161:
8156:
8152:
8146:
8141:
8137:
8131:
8126:
8122:
8116:
8111:
8107:
8101:
8096:
8092:
8086:
8081:
8077:
8071:
8066:
8062:
8056:
8051:
8047:
8041:
8036:
8032:
8026:
8021:
8017:
8011:
8006:
8002:
7996:
7991:
7987:
7981:
7976:
7972:
7966:
7961:
7957:
7951:
7946:
7942:
7936:
7931:
7927:
7921:
7916:
7912:
7906:
7901:
7897:
7891:
7886:
7882:
7876:
7871:
7867:
7861:
7856:
7852:
7846:
7841:
7837:
7831:
7826:
7822:
7816:
7811:
7807:
7801:
7796:
7792:
7786:
7781:
7777:
7771:
7766:
7762:
7756:
7751:
7747:
7741:
7736:
7732:
7726:
7721:
7717:
7711:
7706:
7702:
7696:
7691:
7687:
7681:
7676:
7672:
7666:
7661:
7657:
7651:
7646:
7642:
7636:
7631:
7627:
7621:
7616:
7612:
7606:
7601:
7597:
7591:
7586:
7582:
7576:
7571:
7567:
7561:
7556:
7552:
7546:
7541:
7537:
7531:
7526:
7522:
7516:
7511:
7507:
7501:
7496:
7492:
7486:
7481:
7477:
7471:
7466:
7462:
7456:
7451:
7447:
7441:
7436:
7432:
7426:
7421:
7417:
7411:
7406:
7402:
7396:
7391:
7387:
7381:
7376:
7372:
7366:
7361:
7357:
7351:
7346:
7342:
7336:
7331:
7327:
7321:
7316:
7312:
7306:
7301:
7297:
7291:
7286:
7282:
7276:
7271:
7267:
7261:
7256:
7252:
7246:
7241:
7237:
7231:
7226:
7222:
7216:
7211:
7207:
7201:
7196:
7192:
7186:
7181:
7177:
7171:
7166:
7162:
7156:
7151:
7147:
7141:
7136:
7132:
7126:
7121:
7117:
7111:
7106:
7102:
7096:
7091:
7087:
7081:
7076:
7072:
7066:
7061:
7057:
7051:
7046:
7042:
7036:
7031:
7027:
7021:
7016:
7012:
7006:
7001:
6997:
6991:
6986:
6982:
6976:
6971:
6967:
6961:
6956:
6952:
6946:
6941:
6937:
6931:
6926:
6922:
6916:
6911:
6907:
6901:
6896:
6892:
6886:
6881:
6877:
6871:
6866:
6862:
6856:
6851:
6847:
6841:
6836:
6832:
6826:
6821:
6817:
6811:
6806:
6802:
6796:
6791:
6787:
6781:
6776:
6772:
6766:
6761:
6757:
6751:
6746:
6742:
6736:
6731:
6727:
6721:
6716:
6712:
6706:
6701:
6697:
6691:
6686:
6682:
6676:
6671:
6667:
6661:
6656:
6652:
6646:
6641:
6637:
6631:
6626:
6622:
6616:
6611:
6607:
6601:
6596:
6592:
6586:
6581:
6577:
6571:
6566:
6562:
6556:
6551:
6547:
6541:
6536:
6532:
6526:
6521:
6517:
6511:
6506:
6502:
6496:
6491:
6487:
6481:
6476:
6472:
6466:
6461:
6457:
6451:
6446:
6442:
6436:
6431:
6427:
6421:
6416:
6412:
6406:
6401:
6397:
6391:
6386:
6382:
6376:
6371:
6367:
6361:
6356:
6352:
6346:
6341:
6337:
6331:
6326:
6322:
6316:
6311:
6307:
6301:
6296:
6292:
6286:
6281:
6277:
6271:
6266:
6262:
6256:
6251:
6247:
6241:
6236:
6232:
6226:
6221:
6217:
6211:
6206:
6202:
6196:
6191:
6187:
6181:
6176:
6172:
6166:
6161:
6157:
6151:
6146:
6142:
6136:
6131:
6127:
6121:
6116:
6112:
6106:
6101:
6097:
6091:
6086:
6082:
6076:
6071:
6067:
6061:
6056:
6052:
6046:
6041:
6037:
6031:
6026:
6022:
6016:
6011:
6007:
6001:
5996:
5992:
5986:
5981:
5977:
5971:
5966:
5962:
5956:
5951:
5947:
5941:
5936:
5932:
5926:
5921:
5917:
5911:
5906:
5902:
5896:
5891:
5887:
5881:
5876:
5872:
5866:
5861:
5857:
5851:
5846:
5842:
5836:
5831:
5827:
5821:
5816:
5812:
5806:
5801:
5797:
5791:
5786:
5782:
5776:
5771:
5767:
5761:
5756:
5752:
5746:
5741:
5737:
5731:
5726:
5722:
5716:
5711:
5707:
5701:
5696:
5692:
5686:
5681:
5677:
5671:
5666:
5662:
5656:
5651:
5647:
5641:
5636:
5632:
5626:
5621:
5617:
5611:
5606:
5602:
5596:
5591:
5587:
5581:
5576:
5572:
5566:
5561:
5557:
5551:
5546:
5542:
5536:
5531:
5527:
5521:
5516:
5512:
5506:
5501:
5497:
5491:
5486:
5482:
5476:
5471:
5467:
5461:
5456:
5452:
5446:
5441:
5437:
5431:
5426:
5422:
5416:
5411:
5407:
5401:
5396:
5392:
5386:
5381:
5377:
5371:
5366:
5362:
5356:
5351:
5347:
5341:
5336:
5332:
5326:
5321:
5317:
5311:
5306:
5302:
5296:
5291:
5287:
5281:
5276:
5272:
5266:
5261:
5257:
5251:
5246:
5242:
5236:
5231:
5227:
5221:
5216:
5212:
5206:
5201:
5197:
5191:
5186:
5182:
5176:
5171:
5167:
5161:
5156:
5152:
5146:
5141:
5137:
5131:
5126:
5122:
5116:
5111:
5107:
5101:
5096:
5095:
5092:
5083:
5078:
5076:
5071:
5069:
5064:
5063:
5060:
5053:
5050:
5047:
5044:
5042:
5039:
5037:
5033:
5030:
5027:
5024:
5020:
5018:
5015:
5011:
5007:
5002:
4998:
4994:
4990:
4986:
4981:
4979:
4975:
4972:
4968:
4964:
4963:
4952:
4950:9780824795016
4946:
4942:
4938:
4934:
4930:
4926:
4922:
4918:
4915:(3): 131–42.
4914:
4910:
4909:Blood Reviews
4905:
4901:
4897:
4892:
4887:
4884:(2): 122–30.
4883:
4879:
4875:
4870:
4866:
4862:
4858:
4854:
4850:
4846:
4842:
4838:
4833:
4829:
4825:
4821:
4817:
4814:(3): 151–63.
4813:
4809:
4804:
4800:
4796:
4791:
4786:
4782:
4778:
4774:
4769:
4765:
4761:
4756:
4751:
4748:(6): 824–54.
4747:
4743:
4739:
4734:
4730:
4726:
4722:
4718:
4714:
4710:
4706:
4702:
4697:
4693:
4689:
4685:
4681:
4677:
4673:
4668:
4664:
4660:
4656:
4652:
4648:
4644:
4640:
4636:
4631:
4627:
4623:
4619:
4615:
4611:
4607:
4602:
4598:
4594:
4589:
4584:
4580:
4576:
4573:(3): 248–53.
4572:
4568:
4564:
4559:
4555:
4551:
4547:
4543:
4538:
4533:
4529:
4525:
4524:FASEB Journal
4521:
4516:
4515:
4495:
4491:
4485:
4470:
4464:
4462:
4453:
4449:
4445:
4441:
4437:
4433:
4429:
4425:
4418:
4410:
4406:
4402:
4398:
4394:
4390:
4382:
4374:
4370:
4366:
4362:
4359:(2): 256–65.
4358:
4354:
4346:
4332:
4331:The Economist
4328:
4321:
4313:
4309:
4305:
4301:
4297:
4293:
4286:
4278:
4274:
4269:
4264:
4261:(8): 821–30.
4260:
4256:
4252:
4245:
4237:
4233:
4228:
4223:
4219:
4215:
4211:
4204:
4196:
4192:
4188:
4184:
4180:
4176:
4173:(2): 338–43.
4172:
4168:
4161:
4153:
4149:
4144:
4139:
4135:
4131:
4127:
4120:
4112:
4108:
4104:
4100:
4096:
4092:
4088:
4084:
4077:
4069:
4065:
4060:
4055:
4051:
4047:
4043:
4039:
4035:
4028:
4020:
4016:
4012:
4008:
4004:
4000:
3993:
3985:
3981:
3977:
3973:
3969:
3965:
3961:
3957:
3950:
3942:
3938:
3934:
3930:
3926:
3922:
3918:
3914:
3907:
3903:
3897:
3889:
3885:
3880:
3875:
3871:
3867:
3863:
3856:
3848:
3844:
3839:
3834:
3830:
3826:
3822:
3815:
3807:
3803:
3799:
3795:
3791:
3787:
3784:(5): 349–56.
3783:
3779:
3772:
3764:
3760:
3755:
3750:
3747:(1): 165–72.
3746:
3742:
3738:
3731:
3723:
3719:
3714:
3709:
3705:
3701:
3697:
3693:
3689:
3682:
3674:
3670:
3666:
3662:
3658:
3654:
3653:Ergeb Physiol
3647:
3639:
3635:
3631:
3624:
3616:
3614:9780071833011
3610:
3606:
3599:
3591:
3587:
3583:
3579:
3575:
3571:
3564:
3556:
3552:
3548:
3544:
3540:
3536:
3529:
3521:
3517:
3513:
3509:
3505:
3501:
3498:(3): 285–92.
3497:
3493:
3486:
3478:
3474:
3468:
3460:
3456:
3450:
3443:
3439:
3434:
3432:
3430:
3422:
3418:
3413:
3411:
3409:
3404:
3395:
3392:
3390:
3387:
3384:
3381:
3379:
3376:
3374:
3371:
3369:
3366:
3365:
3359:
3357:
3352:
3349:
3345:
3341:
3331:
3329:
3325:
3321:
3316:
3314:
3310:
3306:
3302:
3298:
3294:
3289:
3287:
3283:
3279:
3270:
3268:
3264:
3260:
3256:
3249:Research tool
3241:
3239:
3235:
3231:
3226:
3222:
3220:
3216:
3212:
3208:
3204:
3200:
3196:
3192:
3188:
3183:
3181:
3177:
3173:
3169:
3165:
3161:
3151:
3149:
3145:
3141:
3137:
3133:
3129:
3125:
3120:
3118:
3108:
3106:
3101:
3096:
3092:
3087:
3085:
3081:
3077:
3073:
3069:
3065:
3060:
3058:
3054:
3046:
3041:
3032:
3030:
3026:
3022:
3018:
3015:expressed by
3014:
3010:
3006:
2996:
2994:
2990:
2985:
2983:
2979:
2975:
2971:
2967:
2965:
2961:
2957:
2953:
2949:
2945:
2941:
2937:
2933:
2929:
2919:
2916:
2911:
2909:
2905:
2901:
2897:
2893:
2889:
2885:
2870:
2868:
2863:
2861:
2851:
2849:
2845:
2841:
2837:
2836:beta-thrombin
2833:
2829:
2825:
2821:
2817:
2813:
2809:
2805:
2804:fibrinogenase
2801:
2798:
2794:
2790:
2786:
2784:
2780:
2776:
2772:
2768:
2764:
2756:
2744:
2739:
2735:
2731:
2728:
2724:
2717:
2715:
2712:
2708:
2704:
2700:
2697:
2693:
2689:
2682:
2680:
2674:
2670:
2667:
2661:
2659:
2653:
2649:
2646:
2642:
2635:
2633:
2627:
2623:
2620:
2614:
2612:
2608:
2602:
2598:
2595:
2593:RefSeq (mRNA)
2591:
2584:
2583:
2578:
2574:
2571:
2565:
2564:
2559:
2555:
2552:
2550:
2546:
2539:
2538:
2533:
2529:
2526:
2520:
2519:
2514:
2510:
2507:
2505:
2501:
2494:
2493:
2488:
2484:
2481:
2475:
2474:
2469:
2465:
2462:
2460:
2456:
2453:
2450:
2448:
2445:
2441:
2438:
2434:
2430:
2423:
2419:
2414:
2408:
2405:
2403:
2400:
2398:
2395:
2393:
2390:
2388:
2385:
2383:
2380:
2378:
2375:
2373:
2370:
2368:
2365:
2363:
2360:
2358:
2355:
2353:
2350:
2348:
2345:
2343:
2340:
2338:
2335:
2333:
2330:
2328:
2325:
2323:
2320:
2318:
2315:
2313:
2310:
2308:
2305:
2303:
2300:
2298:
2295:
2293:
2290:
2288:
2285:
2283:
2280:
2278:
2275:
2273:
2270:
2268:
2265:
2263:
2260:
2258:
2255:
2253:
2250:
2248:
2245:
2243:
2240:
2238:
2235:
2233:
2230:
2228:
2225:
2223:
2220:
2218:
2215:
2213:
2210:
2209:
2207:
2204:
2203:
2197:
2194:
2192:
2189:
2187:
2184:
2182:
2179:
2177:
2174:
2172:
2169:
2167:
2164:
2162:
2159:
2157:
2154:
2153:
2151:
2148:
2147:
2141:
2138:
2136:
2133:
2131:
2128:
2126:
2123:
2121:
2118:
2116:
2113:
2111:
2108:
2106:
2103:
2101:
2098:
2096:
2093:
2091:
2088:
2086:
2083:
2082:
2080:
2077:
2076:
2073:
2072:Gene ontology
2069:
2065:
2053:
2048:
2044:
2039:
2036:
2034:
2030:
2022:
2017:
2006:
2002:
1998:
1994:
1990:
1986:
1982:
1978:
1974:
1970:
1969:
1966:
1962:
1957:
1954:
1944:
1940:
1936:
1932:
1928:
1924:
1920:
1916:
1912:
1908:
1907:
1904:
1900:
1895:
1892:
1891:
1888:
1886:
1882:
1880:
1879:
1875:
1874:
1871:
1869:
1865:
1861:
1857:
1853:
1845:
1840:
1836:
1832:
1827:
1817:
1813:
1806:
1799:
1793:
1786:
1778:
1774:
1770:
1765:
1761:
1756:
1752:
1744:
1739:
1735:
1731:
1726:
1716:
1712:
1705:
1698:
1692:
1685:
1681:
1675:
1671:
1667:
1662:
1658:
1653:
1649:
1645:
1641:
1637:
1633:
1629:
1625:
1621:
1617:
1613:
1609:
1601:
1596:
1589:
1584:
1579:
1568:
1566:
1562:
1558:
1554:
1550:
1546:
1542:
1538:
1534:
1530:
1526:
1522:
1518:
1514:
1510:
1506:
1502:
1498:
1494:
1490:
1486:
1482:
1478:
1474:
1470:
1466:
1462:
1458:
1454:
1450:
1446:
1442:
1438:
1434:
1430:
1426:
1422:
1418:
1414:
1410:
1406:
1402:
1398:
1394:
1390:
1386:
1382:
1378:
1374:
1370:
1366:
1362:
1358:
1354:
1350:
1346:
1342:
1338:
1334:
1330:
1326:
1322:
1318:
1314:
1310:
1306:
1302:
1298:
1294:
1290:
1286:
1282:
1278:
1274:
1270:
1266:
1262:
1258:
1254:
1250:
1246:
1242:
1238:
1234:
1230:
1226:
1222:
1218:
1214:
1210:
1206:
1202:
1198:
1194:
1190:
1186:
1182:
1178:
1174:
1170:
1166:
1162:
1158:
1154:
1150:
1146:
1142:
1138:
1134:
1130:
1126:
1122:
1118:
1114:
1110:
1106:
1102:
1098:
1094:
1090:
1086:
1082:
1078:
1074:
1070:
1066:
1062:
1058:
1054:
1050:
1046:
1042:
1038:
1034:
1030:
1026:
1022:
1018:
1014:
1010:
1006:
1002:
998:
994:
990:
986:
982:
978:
974:
970:
966:
962:
958:
954:
950:
946:
942:
938:
934:
930:
926:
922:
918:
914:
910:
906:
902:
898:
894:
890:
886:
882:
878:
874:
870:
866:
862:
858:
854:
850:
846:
842:
838:
834:
830:
826:
822:
818:
814:
810:
806:
802:
798:
794:
790:
786:
782:
778:
774:
770:
766:
762:
758:
754:
750:
746:
742:
738:
734:
730:
726:
722:
718:
714:
710:
706:
702:
698:
694:
690:
686:
682:
678:
674:
670:
666:
662:
658:
654:
650:
646:
642:
638:
634:
630:
626:
622:
618:
614:
610:
606:
602:
598:
594:
590:
586:
582:
578:
574:
570:
566:
562:
558:
554:
550:
546:
542:
538:
534:
530:
526:
522:
518:
514:
510:
506:
502:
498:
494:
490:
486:
482:
478:
474:
470:
466:
462:
458:
454:
450:
446:
442:
438:
434:
430:
426:
422:
418:
414:
410:
406:
402:
398:
394:
390:
386:
382:
378:
374:
370:
366:
362:
358:
354:
350:
346:
342:
338:
334:
330:
326:
322:
318:
314:
310:
306:
302:
298:
294:
290:
286:
282:
278:
274:
270:
266:
262:
258:
254:
250:
246:
242:
238:
234:
230:
226:
222:
218:
214:
210:
206:
202:
198:
194:
190:
186:
182:
178:
174:
170:
166:
162:
158:
154:
150:
146:
142:
138:
134:
130:
126:
122:
118:
114:
110:
106:
102:
98:
94:
90:
86:
82:
78:
72:
67:
64:
63:
59:
56:
49:
45:
40:
36:
32:
27:
22:
19:
10248:Translocases
10245:
10232:
10219:
10206:
10193:
10183:Transferases
10180:
10167:
10024:Binding site
9736:fibrinolysis
9734:
9615:
9612:
9578:Chymotrypsin
9481:C1-inhibitor
9463:
9439:
9412:
9337:Avatrombopag
9324:
9320:Fostamatinib
9277:
9271:Catridecacog
9262:I/Fibrinogen
9256:
9248:
9242:Eptacog alfa
9234:
9227:Nonacog alfa
9179:
9156:Menadione (K
9056:
9047:Gangliosides
8903:Nucleoporins
8844:Autoantigens
8798:D-Dimer (DD)
8781:Fibrinolysis
8669:-Antiplasmin
8545:
8391:
8315:
8300:
8285:
8270:
8255:
8240:
8225:
8210:
8195:
8180:
8165:
8150:
8135:
8120:
8105:
8090:
8075:
8060:
8045:
8030:
8015:
8000:
7985:
7970:
7955:
7940:
7925:
7910:
7895:
7880:
7865:
7850:
7835:
7820:
7805:
7790:
7775:
7760:
7745:
7730:
7715:
7700:
7685:
7670:
7655:
7640:
7625:
7610:
7595:
7580:
7565:
7550:
7535:
7520:
7505:
7490:
7475:
7460:
7445:
7430:
7415:
7400:
7385:
7370:
7355:
7340:
7325:
7310:
7295:
7280:
7265:
7250:
7235:
7220:
7205:
7190:
7175:
7160:
7145:
7130:
7115:
7100:
7085:
7070:
7055:
7040:
7025:
7010:
6995:
6980:
6965:
6950:
6935:
6920:
6905:
6890:
6875:
6860:
6845:
6830:
6815:
6800:
6785:
6770:
6755:
6740:
6725:
6710:
6695:
6680:
6665:
6650:
6635:
6620:
6605:
6590:
6575:
6560:
6545:
6530:
6515:
6500:
6485:
6470:
6455:
6440:
6425:
6410:
6395:
6380:
6365:
6350:
6335:
6320:
6305:
6290:
6275:
6260:
6245:
6230:
6215:
6200:
6185:
6170:
6155:
6140:
6125:
6110:
6095:
6080:
6065:
6050:
6035:
6020:
6005:
5990:
5975:
5960:
5945:
5930:
5915:
5900:
5885:
5870:
5855:
5840:
5825:
5810:
5795:
5780:
5765:
5750:
5735:
5720:
5705:
5690:
5675:
5660:
5645:
5630:
5615:
5600:
5585:
5570:
5555:
5540:
5525:
5510:
5495:
5480:
5465:
5450:
5435:
5420:
5405:
5390:
5375:
5360:
5345:
5330:
5315:
5300:
5285:
5270:
5255:
5240:
5225:
5210:
5195:
5180:
5165:
5150:
5135:
5120:
5105:
4988:
4940:
4912:
4908:
4881:
4877:
4840:
4836:
4811:
4807:
4783:(1): 41–53.
4780:
4776:
4745:
4741:
4707:(2): 211–6.
4704:
4700:
4678:(2): 173–7.
4675:
4671:
4641:(1): 34–40.
4638:
4634:
4609:
4605:
4570:
4566:
4527:
4523:
4498:. Retrieved
4493:
4484:
4473:. Retrieved
4430:(3): 371–9.
4427:
4423:
4417:
4395:(1): 68–74.
4392:
4388:
4381:
4356:
4352:
4345:
4334:. Retrieved
4330:
4320:
4295:
4291:
4285:
4258:
4254:
4244:
4217:
4213:
4203:
4170:
4166:
4160:
4136:(3): e15–8.
4133:
4129:
4119:
4089:(2): 203–9.
4086:
4082:
4076:
4041:
4038:Biochemistry
4037:
4027:
4002:
3998:
3992:
3959:
3955:
3949:
3919:(9): 751–6.
3916:
3912:
3896:
3869:
3865:
3855:
3828:
3824:
3814:
3781:
3777:
3771:
3744:
3740:
3730:
3698:(3): 29–51.
3695:
3692:Acta Naturae
3691:
3681:
3656:
3652:
3646:
3629:
3623:
3604:
3598:
3573:
3569:
3563:
3538:
3535:Biochemistry
3534:
3528:
3495:
3491:
3485:
3476:
3467:
3458:
3449:
3385:of proteases
3368:Cerastocytin
3353:
3337:
3317:
3290:
3276:
3252:
3244:Applications
3227:
3223:
3184:
3157:
3124:heterozygous
3121:
3114:
3088:
3061:
3050:
3025:antithrombin
3002:
2986:
2970:Factor XIIIa
2968:
2925:
2915:antithrombin
2912:
2881:
2864:
2857:
2839:
2835:
2831:
2827:
2823:
2819:
2815:
2811:
2807:
2803:
2792:
2788:
2787:
2773:gene. It is
2770:
2766:
2762:
2761:
2676:
2655:
2629:
2611:NM_001311257
2604:
2580:
2561:
2535:
2516:
2490:
2471:
2451:
2446:
2347:fibrinolysis
1883:
1876:
1603:External IDs
74:
18:
10019:Active site
9641:Factor XIIa
9621:Factor VIIa
9605:Coagulation
9496:Ulinastatin
9441:amino acids
9398:Fibrin glue
9389:Epinephrine
9342:Eltrombopag
9332:Romiplostim
9257:II/Thrombin
9170:Coagulation
9122:coagulation
9032:Cardiolipin
8635:Plasminogen
8570:Factor XIII
8488:Factor VIII
5088:PDB gallery
4989:GeneReviews
4843:(1): 63–9.
4255:Circulation
4130:Circulation
3659:: 307–422.
3576:: 413–538.
3373:Fibrin glue
3230:blood clots
3095:prothrombin
3017:endothelial
2867:Pekelharing
2824:tropostasin
2812:thrombofort
2763:Prothrombin
2357:proteolysis
2171:Golgi lumen
1987:human fetus
1979:gallbladder
1842:91,466,759
1829:91,455,665
1741:46,739,506
1728:46,719,196
1581:Identifiers
10291:Categories
10222:Isomerases
10196:Hydrolases
10063:Regulation
9923:Subtilisin
9865:Batroxobin
9646:Kallikrein
9636:Factor XIa
9626:Factor IXa
9593:Pancreatic
9588:Neutrophil
9393:adrenalone
9315:Etamsylate
9310:Concizumab
9300:Batroxobin
9235:extrinsic:
9180:intrinsic:
9037:Centromere
8513:Factor VII
8468:Kallikrein
8458:Bradykinin
5016:-animation
4999:. NBK1148.
4500:2019-02-28
4475:2010-10-17
4336:2013-12-15
3444:, May 2017
3423:, May 2017
3400:References
3378:Fibrinogen
3340:fibrinogen
3328:hemostasis
3234:iron oxide
3215:infarction
3197:following
3164:antibodies
3132:thrombosis
3128:homozygous
3064:Gla domain
3045:Gla domain
2940:fibrinogen
2934:to VIIIa,
2873:Physiology
2832:E thrombin
2820:thrombin-C
2793:Factor IIa
2322:hemostasis
1887:(ortholog)
1624:HomoloGene
10312:EC 3.4.21
10101:EC number
9951:Cathepsin
9937:Sedolisin
9913:Prostasin
9631:Factor Xa
9492:unsorted
9471:Aprotinin
9139:Vitamin K
8789:Plasmin-α
8650:Urokinase
8483:Factor IX
8478:Factor XI
5025:/Thrombin
4865:260320933
4019:0001-4842
3909:;
3638:599096191
3351:quality.
3324:topically
3309:factor Xa
3301:vitamin K
3195:vasospasm
3080:Factor Xa
3035:Structure
3021:protein S
3005:protein C
2978:interacts
2928:factor XI
2896:vitamin K
2878:Synthesis
2869:in 1894.
2808:thrombase
2679:NP_034298
2658:NP_000497
2632:NM_010168
2607:NM_000506
2437:Orthologs
1632:GeneCards
10125:Kinetics
10049:Cofactor
10012:Activity
9852:Venombin
9837:Tryptase
9832:Granzyme
9786:Factor I
9781:Factor D
9776:Factor B
9616:Thrombin
9613:factors:
9583:Elastase
9486:Camostat
9413:Thrombin
9384:Collagen
9293:systemic
9131:Systemic
9057:Thrombin
8536:Factor V
8531:Factor X
5032:Archived
4997:20301327
4974:Archived
4929:17208341
4900:16480903
4857:15034798
4828:14739624
4799:14551154
4764:12466191
4729:32822567
4721:12023853
4692:12023846
4663:74389210
4655:11487023
4597:20541575
4554:19565674
4444:19349898
4409:19651065
4373:17660072
4312:21542745
4277:20697022
4236:19228706
4195:19895315
4187:17156138
4152:15262854
4111:20144699
4068:26468766
3984:36616995
3976:16673262
3933:12923575
3806:11358104
3798:22759629
3722:22649613
3673:84003009
3590:37273997
3520:45686258
3440:–
3419:–
3362:See also
3297:Warfarin
3286:warfarin
3259:arginine
3148:factor V
3100:β-barrel
3084:factor V
3078:domain.
2989:platelet
2930:to XIa,
2908:warfarin
2888:Factor V
2884:Factor X
2800:3.4.21.5
2789:Thrombin
2727:Wikidata
2416:Sources:
1983:yolk sac
1913:testicle
10281:Biology
10235:Ligases
10005:Enzymes
9891:Pronase
9881:Acrosin
9827:Chymase
9741:Plasmin
9573:Trypsin
9465:serpins
9249:common:
9172:factors
8640:Plasmin
5052:PDBe-KB
5046:PDBe-KB
5010:YouTube
4971:S01.217
4937:Degen S
4626:9834200
4588:2910823
4546:7615164
4496:. Sonac
4452:3678462
4103:7792730
4059:4697735
3941:7751100
3888:2544585
3847:8663147
3763:3593964
3713:3347534
3555:2825773
3512:3474786
3442:Ensembl
3421:Ensembl
3383:PA clan
3344:porcine
3311:). The
3305:Heparin
3263:glycine
3191:mitogen
3138:(i.e.,
3072:trypsin
3057:PA clan
3013:protein
2938:to Va,
2854:History
2842:) is a
2816:topical
2781:by the
2549:UniProt
2504:Ensembl
2443:Species
2422:QuickGO
1862:pattern
1720:11p11.2
1588:Aliases
10267:Portal
10209:Lyases
9918:Reelin
9860:Ancrod
9817:Other
9551:3.4.21
9001:NUP214
8996:NUP205
8991:NUP210
8986:NUP188
8981:NUP160
8976:NUP155
8971:NUP153
8966:NUP133
8961:NUP107
8427:GPIIIa
5021:PMAP:
4995:
4967:MEROPS
4947:
4927:
4898:
4863:
4855:
4826:
4797:
4762:
4727:
4719:
4690:
4661:
4653:
4624:
4595:
4585:
4552:
4544:
4450:
4442:
4407:
4371:
4310:
4275:
4234:
4193:
4185:
4150:
4109:
4101:
4066:
4056:
4017:
3982:
3974:
3939:
3931:
3886:
3845:
3804:
3796:
3761:
3720:
3710:
3671:
3636:
3611:
3588:
3553:
3518:
3510:
3348:bovine
3219:stroke
3207:artery
3074:-like
3066:, two
2946:, and
2944:fibrin
2848:fibrin
2713:search
2711:PubMed
2582:P19221
2563:P00734
2459:Entrez
2033:BioGPS
2007:zygote
1995:morula
1945:embryo
1941:fundus
1917:oocyte
1612:176930
10161:Types
9927:Furin
9874:Other
9801:MASP2
9796:MASP1
9726:KLK15
9721:KLK14
9716:KLK13
9711:KLK12
9706:KLK11
9701:KLK10
9367:Local
9291:Other
9022:Actin
9010:Other
8956:NUP98
8951:NUP93
8946:NUP88
8941:NUP85
8936:NUP62
8931:NUP54
8926:NUP50
8921:NUP43
8916:NUP37
8911:NUP35
8422:GPIIb
8407:GP1BB
8402:GP1BA
4861:S2CID
4725:S2CID
4659:S2CID
4606:Blood
4550:S2CID
4448:S2CID
4191:S2CID
4107:S2CID
3980:S2CID
3937:S2CID
3802:S2CID
3741:Blood
3669:S2CID
3586:S2CID
3516:S2CID
3238:urine
3082:with
2980:with
2972:is a
2492:14061
2452:Mouse
2447:Human
2418:Amigo
1885:Mouse
1878:Human
1825:Start
1760:Mouse
1724:Start
1657:Human
1620:88380
10253:list
10246:EC7
10240:list
10233:EC6
10227:list
10220:EC5
10214:list
10207:EC4
10201:list
10194:EC3
10188:list
10181:EC2
10175:list
10168:EC1
9941:TPP1
9791:MASP
9696:KLK9
9691:KLK8
9686:KLK7
9681:KLK6
9676:KLK5
9671:KLK4
9666:KLK3
9661:KLK2
9656:KLK1
9267:XIII
9185:VIII
8316:8kme
8301:7kme
8286:5gds
8271:4thn
8256:4htc
8241:3hat
8226:2thf
8211:2od3
8196:2jh6
8181:2jh5
8166:2jh0
8151:2hwl
8136:2hpq
8121:2hpp
8106:2hnt
8091:2hgt
8076:2h9t
8061:2gp9
8046:2gde
8031:2fes
8016:2feq
8001:2cn0
7986:2cf9
7971:2cf8
7956:2c93
7941:2c90
7926:2c8z
7911:2c8y
7896:2c8x
7881:2c8w
7866:2bxu
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7836:2bvx
7821:2bvs
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7791:2bdy
7776:2b5t
7761:2anm
7746:2ank
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7716:2a45
7701:2a2x
7686:2a0q
7671:1zrb
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7626:1z8j
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7041:1shh
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6996:1sb1
6981:1riw
6966:1rd3
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6921:1qj6
6906:1qj1
6891:1qhr
6876:1qbv
6861:1ppb
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6831:1oyt
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6801:1o5g
6786:1o2g
6771:1o0d
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6741:1ny2
6726:1nu9
6711:1nu7
6696:1nt1
6681:1nrs
6666:1nrr
6651:1nrq
6636:1nrp
6621:1nro
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6576:1nm6
6561:1mue
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6531:1mu6
6516:1mh0
6501:1lhg
6486:1lhf
6471:1lhe
6456:1lhd
6441:1lhc
6426:1ktt
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6396:1k22
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6096:1h8d
6081:1gj5
6066:1gj4
6051:1ghy
6036:1ghx
6021:1ghw
6006:1ghv
5991:1g37
5976:1g32
5961:1g30
5946:1fph
5931:1fpc
5916:1eol
5901:1eoj
5886:1eb1
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5826:1dwd
5811:1dwc
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5781:1doj
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5721:1d9i
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5631:1d3d
5616:1ca8
5601:1c5o
5586:1c5n
5571:1c5l
5556:1c4y
5541:1c4v
5526:1c4u
5511:1c1w
5496:1c1v
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5316:1awf
5301:1aix
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5211:1abi
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4925:PMID
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4853:PMID
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4760:PMID
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4622:PMID
4593:PMID
4542:PMID
4440:PMID
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4273:PMID
4232:PMID
4183:PMID
4148:PMID
4099:PMID
4064:PMID
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3972:PMID
3929:PMID
3906:1nl2
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3843:PMID
3794:PMID
3759:PMID
3718:PMID
3634:OCLC
3609:ISBN
3551:PMID
3508:PMID
3280:and
3261:and
3213:and
3189:and
3111:Gene
3027:, a
2962:and
2954:and
2948:XIII
2932:VIII
2473:2147
1868:Bgee
1816:Band
1777:Chr.
1715:Band
1674:Chr.
1608:OMIM
1565:5JDU
1561:5A2M
1557:4UFF
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1537:5EDM
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1525:5AHG
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1401:3K65
1397:3JZ1
1393:3EGK
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1385:2ZHQ
1381:2ZGX
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1369:2ZFF
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1357:2ZDA
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1317:2CF9
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1305:2C90
1301:2C8Z
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1285:1TMT
1281:1TBZ
1277:1NO9
1273:1IHT
1269:1HGT
1265:1HDT
1261:1HAH
1257:1HAG
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1241:1AFE
1237:1A61
1233:1A5G
1229:1A4W
1225:1A46
1221:8KME
1217:7KME
1213:5GDS
1209:4THN
1205:4HTC
1201:4HFP
1197:4H6T
1193:4H6S
1189:4E7R
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1181:4E05
1177:4DY7
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1129:3VXE
1125:3UWJ
1121:3UTU
1117:3U9A
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1109:3U8T
1105:3U8R
1101:3U8O
1097:3U69
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1089:3T5F
1085:3SV2
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1077:3SQE
1073:3SI4
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1065:3SHC
1061:3SHA
1057:3S7K
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1041:3RMM
1037:3RML
1033:3RM2
1029:3RM0
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1021:3RLW
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1013:3QX5
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1005:3QTV
1001:3QTO
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937:3F68
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925:3E6P
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909:3DA9
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897:3C1K
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