38:
273:
In response to criticisms of the
September 2015 price increases, Turing Pharmaceuticals announced various patient affordability and access initiatives and in November 2015 the company reduced the cost of Daraprim for hospitals by up to 50% of the increased rate. Despite these partial rollbacks to
290:, the settlement "requires Vyera and Phoenixus to provide up to $ 40 million in relief over 10 years to consumers who allegedly were fleeced by their actions and requires them to make Daraprim available to any potential generic competitor at the cost of producing the drug." According to
559:
315:
This product, also called TUR-001, is Turing
Pharmaceuticals' oxytocin nasal solution. Syntocinon, short for 'synthetic oxytocin', was first introduced by the Swiss pharmaceutical company Sandoz in 1956. The product had gained FDA approval in 1960 to assist in initial
563:
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200:. The company was widely criticized for raising the price of daraprim by 5456% following its acquisition of rights to the drug in 2015. The company's stock price dropped around 10% after the price increase of the drug. CEO
660:
285:
In
January 2020 the FTC filed a case against Vyera "alleging an elaborate anticompetitive scheme to preserve a monopoly for the life-saving drug, Daraprim". A settlement was reached in December 2021. According to
246:
In
September 2015, Turing raised the price of Daraprim from $ 13.50 to $ 750 a tablet. This increase prompted widespread criticism of the company from many quarters, including the pharmaceutical industry itself.
860:
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266:, and has been available since 1953. At the time of the Daraprim acquisition Turing Pharmaceuticals indicated that it intended to develop new toxoplasmosis drug candidates with better
890:
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the product from
Novartis in December 2013 in order to bring it back to the market for postpartum milk ejection as well as look into its use in the treatment of
739:
917:
838:
282:, since Turing's acquisition to the rights in Daraprim, the drug has gone from being affordable and readily available to being prohibitively expensive.
250:
Shkreli resigned as Turing
Pharmaceuticals' CEO on 18 December 2015, following his arrest on charges of defrauding investors in his former hedge fund.
797:
922:
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433:
533:
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560:"Launch of Turing Pharmaceuticals Announced – New Drug Company to Focus on Treating Unmet Medical Needs Across Broad Therapeutic Areas"
612:
818:
294:, Kevin Mulleady "agreed to a seven-year ban on working for or holding more than an 8% share in most pharmaceutical companies."
17:
777:
369:
392:, TRP-004 for toxoplasmosis, TRP-005 for epileptic encephalopathy, and TRP-011 for congenital metabolic disorder.
336:. Turing Pharmaceuticals is preparing for a Phase III in lactation and other indications are planned.
782:
385:
365:
437:
376:. A Phase I Clinical Trial of TUR 004 for epileptic encephalopathies commenced in November 2015.
125:
681:"Turing Pharmaceuticals LLC Announces Improvements in Daraprim Accessibility and Affordability"
887:"Turing Initiates Dosing in Phase I Clinical Trial of TUR 004 for Epileptic Encephalopathies"
325:
212:
661:"CEO who raised price of old pill more than $ 700 calls journalist a 'moron' for asking why"
932:
239:
nasal solution, and
Vecamyl. The company acquired the US marketing rights to Daraprim from
181:. The company started to do business in the US as Vyera Pharmaceuticals in September 2017.
8:
665:
586:"Turing Pharmaceuticals AG Acquires U.S. Marketing Rights to DARAPRIM® (pyrimethamine)"
360:
This product is under development for the treatment of seizures associated with severe
240:
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349:
274:
the initial price increase, according to
February 2, 2016, memo from Representative
459:
408:
275:
58:
48:
204:
faced immense criticism for his actions. The company was previously named after
839:"Retrophin Signs U.S. License Agreement for Syntocinon™ Nasal Spray (Oxytocin)"
483:"Turing Pharma Says Daraprim Availability Will Be Unaffected By Shkreli Arrest"
389:
224:
201:
166:
89:
262:, which is indicated for the treatment of toxoplasmosis in combination with a
911:
329:
259:
189:
185:
178:
102:
197:
193:
344:
509:"Gadfly Pharma Investor Shkreli Starts Anew After Ousting From Retrophin"
263:
228:
205:
174:
110:
638:"Martin Shkreli resigns from Turing Pharmaceuticals after fraud charges"
819:"Former Shkreli Co. Inks Deal Worth Up To $ 40M With FTC, AGs - Law360"
317:
534:"Convicted pharma fraudster Shkreli's companies file for bankruptcy"
361:
345:
321:
236:
232:
302:
Vecamyl is currently indicated for the treatment of hypertension.
802:
287:
280:
United States House
Committee on Oversight and Government Reform
823:
368:
filing for TUR-004 in October 2015 and the product was granted
333:
291:
348:. The company is working on the product for the treatment of
37:
861:"Turing Pharmaceuticals AG Announces IND Filing for TUR-004"
798:"'Pharma Bro' firm reaches $ 40M settlement in gouging case"
267:
231:
developer called Retrophin: an intranasal formulation of
373:
170:
106:
223:
Turing Pharmaceuticals was launched in February 2015 by
145:
928:
Companies that filed for Chapter 11 bankruptcy in 2023
384:
Turing Pharmaceuticals is also working on TRP-001 for
320:, but was discontinued by Sandoz's successor company,
709:. Turingpharma.com. November 24, 2015. Archived from
562:. Turingpharma.com. February 24, 2015. Archived from
889:. Turinpharma.com. November 16, 2015. Archived from
683:. Turingpharma.com. October 13, 2015. Archived from
863:. Turingpharma.com. October 5, 2015. Archived from
588:. Turingpharma.com. August 10, 2015. Archived from
227:with the acquisition of three major assets from an
707:"Turing Reduces Cost of Daraprim® (pyrimethamine)"
658:
388:, TRP-002 for developmental disorder, TRP-003 for
184:The company has two marketed products: Daraprim (
909:
379:
324:, in 1997 because of poor sales. Retrophin had
436:. Louisiana Secretary of State. Archived from
434:"Corporation Filings 08/27/2017 to 09/03/2017"
613:"A Timeline of the Turing Pharma Controversy"
460:"Oxytocin intranasal - Vyera Pharmaceuticals"
918:Pharmaceutical companies established in 2015
610:
364:disorders. Turing Pharmaceuticals made an
36:
506:
258:Daraprim is the trade name for the drug
923:Pharmaceutical companies of Switzerland
611:Timmermann, Like (September 23, 2015).
507:Weintraub, Arlene (February 27, 2015).
14:
910:
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762:: CS1 maint: archived copy as title (
480:
640:. Theguardian.com. December 19, 2015
196:hydrochloride) for the treatment of
481:Mullin, Emily (February 27, 2015).
24:
841:. Business Wire. December 12, 2013
817:Koenig, Bryan (December 7, 2021).
25:
944:
659:Ariana Eunjung Cha (2015-09-22).
211:On May 10, 2023, Vyera filed for
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380:Other products in development
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778:"Vyera Pharmaceuticals, LLC"
7:
305:
253:
10:
949:
386:glycogen storage disorders
355:
339:
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208:, the computer scientist.
70:; 9 years ago
140:
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116:
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64:
54:
44:
35:
783:Federal Trade Commission
318:postpartum milk ejection
188:), for the treatment of
169:company incorporated in
126:Chief Executive Officer
413:Turing Pharmaceuticals
370:Fast Track designation
163:Turing Pharmaceuticals
27:Pharmaceutical company
18:Turing Pharmaceuticals
213:Chapter 11 bankruptcy
159:Vyera Pharmaceuticals
31:Vyera Pharmaceuticals
566:on 26 September 2015
893:on 22 December 2015
867:on 22 December 2015
806:. December 8, 2021.
786:. January 27, 2020.
713:on 22 December 2015
687:on 22 December 2015
666:The Washington Post
538:Wall Street Journal
32:
440:on 15 January 2022
241:Impax Laboratories
177:, with offices in
68:February 2015
30:
409:"Leadership Team"
156:
155:
136:Vecamyl, Daraprim
128:
16:(Redirected from
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243:in August 2015.
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733:"Archived copy"
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592:on 4 March 2016
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276:Elijah Cummings
270:than Daraprim.
256:
221:
192:, and Vecamyl (
144:
123:
122:Justin Garrett
119:
94:
74:
72:
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59:Pharmaceuticals
28:
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540:. May 10, 2023
525:
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390:leukodystrophy
381:
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225:Martin Shkreli
220:
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202:Martin Shkreli
167:pharmaceutical
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90:Martin Shkreli
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745:on 2016-03-20
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462:. AdisInsight
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260:pyrimethamine
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190:toxoplasmosis
187:
186:pyrimethamine
182:
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895:. Retrieved
891:the original
881:
869:. Retrieved
865:the original
855:
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833:
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685:the original
675:
664:
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632:
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616:
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590:the original
580:
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512:
502:
490:. Retrieved
486:
476:
466:24 September
464:. Retrieved
454:
444:24 September
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438:the original
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416:. Retrieved
412:
403:
383:
359:
343:
314:
301:
284:
272:
257:
249:
245:
222:
210:
198:hypertension
194:mecamylamine
183:
162:
158:
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99:Headquarters
45:Company type
933:Alan Turing
897:19 December
871:19 December
845:19 December
717:19 December
691:19 December
644:19 December
622:19 December
596:19 December
570:19 December
518:19 December
418:20 December
350:suicidality
264:sulfonamide
229:orphan drug
206:Alan Turing
175:Switzerland
111:Switzerland
912:Categories
749:2016-02-04
617:Forbes.com
513:Forbes.com
492:2 February
487:Forbes.com
396:References
311:Syntocinon
219:Background
161:(formerly
118:Key people
758:cite web
362:epilepsy
346:ketamine
326:licensed
322:Novartis
306:Pipeline
254:Daraprim
237:oxytocin
233:ketamine
133:Products
55:Industry
803:AP News
544:May 10,
372:by the
356:TUR-004
340:TUR-002
298:Vecamyl
288:AP News
278:to the
165:) is a
141:Website
83:Founder
75:2015-02
73: (
65:Founded
49:Private
824:Law360
334:autism
292:Law360
148:.vyera
743:(PDF)
736:(PDF)
235:, an
899:2015
873:2015
847:2015
764:link
719:2015
693:2015
646:2015
624:2015
598:2015
572:2015
546:2023
520:2015
494:2016
468:2017
446:2017
420:2016
332:and
268:ADME
150:.com
105:and
374:FDA
366:IND
171:Zug
146:www
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Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
