1130:{{GNF_Protein_box/sandbox2 | Name = Glucuronidase, beta | image = Protein_GUSB_PDB_1bhg.png | image_source = ] rendering based on 1bhg. | PDB = {{PDB2|1BHG}}, {{PDB2|3HN3}} | HGNCid = 4696 | MGIid = 95872 | Symbol = GUSB | AltSymbols =; BG; MPS7 | IUPHAR = | ChEMBL = 2728 | OMIM = 611499 | ECnumber = 3.2.1.31 | Homologene = 37271 | GeneAtlas_image1 = PBB_GE_GUSB_202605_at_tn.png | GeneAtlas_image2 = | GeneAtlas_image3 = | Protein_domain_image = | Function = {{GNF_GO|id=GO:0004566 |text = beta-glucuronidase activity}} | Component = {{GNF_GO|id=GO:0043202 |text = lysosomal lumen}} {{GNF_GO|id=GO:0043231 |text = intracellular membrane-bounded organelle}} | Process = {{GNF_GO|id=GO:0005975 |text = carbohydrate metabolic process}} {{GNF_GO|id=GO:0006027 |text = glycosaminoglycan catabolic process}} {{GNF_GO|id=GO:0030203 |text = glycosaminoglycan metabolic process}} {{GNF_GO|id=GO:0030212 |text = hyaluronan metabolic process}} {{GNF_GO|id=GO:0030214 |text = hyaluronan catabolic process}} {{GNF_GO|id=GO:0044281 |text = small molecule metabolic process}} | Hs_EntrezGene = 2990 | Hs_Ensembl = ENSG00000169919 | Hs_RefseqmRNA = NM_000181 | Hs_RefseqProtein = NP_000172 | Hs_GenLoc_db = hg19 | Hs_GenLoc_chr = 7 | Hs_GenLoc_start = 65425671 | Hs_GenLoc_end = 65447301 | Hs_Uniprot = P08236 | Mm_EntrezGene = 110006 | Mm_Ensembl = ENSMUSG00000025534 | Mm_RefseqmRNA = NM_010368 | Mm_RefseqProtein = NP_034498 | Mm_GenLoc_db = mm9 | Mm_GenLoc_chr = 5 | Mm_GenLoc_start = 129989011 | Mm_GenLoc_end = 130003049 | Mm_Uniprot = P12265 | path = PBB/2990 | Diseases = ]<ref>{{cite journal|authors=Vervoort R; Islam MR; Sly WS; Zabot MT; Kleijer WJ; Chabas A; Fensom A; Young EP; Liebaers I; Lissens W |title=Molecular analysis of patients with beta-glucuronidase deficiency presenting as hydrops fetalis or as early mucopolysaccharidosis VII|journal=American journal of human genetics|date=March 1996 |volume=58|issue=3|pages=457-71|pmid=8644704}}</ref> }}
556:{{Infobox medical condition/sandbox3 | Name = Coenzyme Q10 deficiency | Image = Ubiquinone.png | Alt = | Caption = Ubiquinone | DiseasesDB = 32701 | ICD10 = | ICD9 = | ICDO = | DO = 0050730 | OMIM = | OMIM_mult = | MedlinePlus = | eMedicineSubj = | eMedicineTopic = | MeshID = C564403 | genes = ]<ref>{{OMIM|607426}}</ref>, ]<ref>{{OMIM|614650}}</ref>, ]<ref>{{OMIM|614652}}</ref>, ]<ref>{{OMIM|614651}}</ref>, ]<ref>{{cite journal|authors=Mollet J; Delahodde A; Serre V; Chretien D; Schlemmer D; Lombes A; Boddaert N; Desguerre I; de Lonlay P; de Baulny HO; Munnich A; Rötig A |title=CABC1 gene mutations cause ubiquinone deficiency with cerebellar ataxia and seizures |journal=American journal of human genetics|date=March 2008 |volume=82|issue=3|pages=623-30|pmid=18319072}}</ref><ref>{{OMIM|606980}}</ref>, ]<ref>{{OMIM|614654}}</ref> | drugs = ] | classification = inherited metabolic disorder | Orphanet = 35656 | OMIM_table = {{infobox3cols | above = OMIM Phenotypic Series | label18 = Coenzyme Q10 deficiency, primary, 1 | data18a = {{OMIM2|607426}} | data18b = ] | label19 = Coenzyme Q10 deficiency, primary, 2 | data19a = {{OMIM2|614651}} | data19b = ] | label20 = Coenzyme Q10 deficiency, primary, 3 | data20a = {{OMIM2|614652}} | data20b = ] | label21 = Coenzyme Q10 deficiency, primary, 4 | data21a = {{OMIM2|612016}} | data21b = ] | label22 = Coenzyme Q10 deficiency, primary, 5 | data22a = {{OMIM2|614654}} | data22b = ] | label23 = Coenzyme Q10 deficiency, primary, 6 | data23a = {{OMIM2|614650}} | data23b = ] }} }}
1078:{{Drugbox/sandbox2 | drug_name = vemurafenib | verifiedrevid = 432742697 | image = PLX4032_BRAF_inhibitor.png <!--Clinical data--> | tradename = Zelboraf | licence_US = Vemurafenib | pregnancy_US = D | legal_US = Rx-only | routes_of_administration = Oral | Drugs.com = {{Drugs.com|pro|zelboraf}} | MedlinePlus = <!--Pharmacodynamic data--> | Therapeutic_use = ] | Biological_target = ] | MOA_text = ] | PDB_ligand = 032 | PDB_complex = 3og7 <!--Identifiers--> | CAS_number = 1029872-54-5 | ATC_prefix = L01 | ATC_suffix = XE15 | PubChem = 42611257 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 24747352 | ChEMBL = 1229517 | UNII = 207SMY3FQT <!--Chemical data--> | C=23 | H=18 | Cl=1 | F=2 | N=3 | O=3 | S=1 | molecular_weight = 489.92 g/mol | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C23H18ClF2N3O3S/c1-2-9-33(31,32)29-19-8-7-18(25)20(21(19)26)22(30)17-12-28-23-16(17)10-14(11-27-23)13-3-5-15(24)6-4-13/h3-8,10-12,29H,2,9H2,1H3,(H,27,28) | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = GPXBXXGIAQBQNI-UHFFFAOYSA-N }} |}
546:{{Infobox_disease/sandbox2 | Name = Sly syndrome | Image = | Caption = | DiseasesDB = 8389 | MalaCards = CYS001 | ICD10 = {{ICD10|E|76|2|e|70}} | ICD9 = {{ICD9|277.5}} | ICDO = | OMIM = 253220 | DO = 12803 | MedlinePlus = | eMedicineSubj = ped | eMedicineTopic = 858 | MeshID = D016538 | Synonyms = MUCOPOLYSACCHARIDOSIS TYPE VII | genes = ]<ref>{{cite journal|authors=Vervoort R; Islam MR; Sly WS; Zabot MT; Kleijer WJ; Chabas A; Fensom A; Young EP; Liebaers I; Lissens W|title=Molecular analysis of patients with beta-glucuronidase deficiency presenting as hydrops fetalis or as early mucopolysaccharidosis VII |journal=American journal of human genetics|date=March 1996 |volume=58|issue=3|pages=457-71|pmid=8644704}}</ref> | Orphanet = 584 | classification = ] | phenotypes = * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * }}
551:{{Infobox medical condition/sandbox2 |Name = Sanfilippo Syndrome |Image = |Caption = |DiseasesDB = 29177 |ICD10 = {{ICD10|E|76|2|e|70}} |ICD9 = {{ICD9|277.5}} |ICDO = |MedlinePlus = 001210 |eMedicineSubj = ped |eMedicineTopic = 2040 |MeshID = D009084 |OMIM_table = {{infobox3cols | above = OMIM Phenotypic Series | label1 = MUCOPOLYSACCHARIDOSIS TYPE IIIA | data1a = {{OMIM2|252900}} | data1b = ] | label2 = MUCOPOLYSACCHARIDOSIS TYPE IIIB | data2a = {{OMIM2|252920}} | data2b = ] | label3 = MUCOPOLYSACCHARIDOSIS TYPE IIIC | data3a = {{OMIM2|252930}} | data3b = ] | label4 = MUCOPOLYSACCHARIDOSIS TYPE IIID | data4a = {{OMIM2|252940}} | data4b = ] }} }}
561:{{Infobox medical condition/sandbox2 |Name = Melanoma |Image = Melanoma.jpg |Caption = a melanoma |Width = 250 |DiseasesDB = 7947 |ICD10 = {{ICD10|C|43||c|43}} |ICD9 = {{ICD9|172.9}} |ICDO = {{ICDO|8720|3}} |OMIM = 155600 |MedlinePlus = 000850 |eMedicineSubj = derm |eMedicineTopic = 257 |eMedicine_mult = {{eMedicine2|med|1386}} {{eMedicine2|ent|27}} {{eMedicine2|plastic|456}} |MeshID = D008545 |BioVex |drugs = ], ], ], ], ], ] |classification = ] |DO = 1909 |subtypes = * ] * ] * ] * ] * ] }}
541:{{Infobox medical condition/sandbox2 | Name = Cystic fibrosis | Image = ClubbingCF.JPG | Alt = | Caption = ] in the fingers of a person with cystic fibrosis | DiseasesDB = 3347 | MalaCards = CYS001 | ICD10 = {{ICD10|E|84||e|70}} | ICD9 = {{ICD9|277.0}} | ICDO = | OMIM = 219700 | MedlinePlus = 000107 | eMedicineSubj = ped | eMedicineTopic = 535 | MeshID = D003550 | GeneReviewsID = | GeneReviewsName = }}
35:
project to other biomedical concepts. Specifically, we are targeting human diseases and phenotypes, and drugs/compounds. Additional organization around SNPs and pathways are a possibility as well.
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All data in this Phase 3 proposal will likely go into
Wikidata. Discussion of that effort can be found at
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The goal of this phase of the
ProteinBoxBot is to expand beyond the genes and proteins maintained in the
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http://www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm?fuseaction=Search.Search_Drug_Name
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Coenzyme Q10 deficiency: matches multiple OMIM entries comprising an entire phenotypic series
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Sanfilippo syndrome: matches multiple OMIM entries, a subset of a phenotypic series
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Drugbank (though note possible data quality issues with brand/trade names
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Sly syndrome: matches a single OMIM entry in a broader phenotypic series
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Please add your ideas and suggestions below and/or contribute to the
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currently runs every two days to maintain gene/protein infoboxes
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Cystic fibrosis: single OMIM entry, no phenotypic series
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http://apps.who.int/classifications/icd10/browse/2010/en
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Melanoma: complex disease with multiple OMIM matches?
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56:{{
45:
44:
36:
30:
1061:Description
900:DrugBank ID
444:GeneReviews
430:Orphanet ID
347:MedlinePlus
1137:References
860:ChemSpider
846:PubChem ID
826:ATC_suffix
808:ATC_prefix
790:CAS number
605:Parameter
481:References
290:DiseasesDB
274:phenotypes
121:Reference
112:Parameter
1002:Mol. mass
918:ChEMBL ID
652:Mechanism
462:MalaCards
365:eMedicine
312:ICD-10 ID
69:d:WD:MBTF
39:talk page
33:Gene Wiki
1123:Examples
1071:Examples
1059:NDF-RT (
936:ChEBI ID
896:DrugBank
830:ATC code
812:ATC code
516:Examples
426:Orphanet
404:UMLS_CUI
330:ICD-9 ID
162:(17653)
149:synonyms
27:Overview
986:Formula
882:UNII ID
843:PubChem
614:Source
579:Drugbox
420:(8390)
398:(3221)
341:(3335)
198:(1749)
187:OMIM ID
143:(8699)
76:Disease
914:ChEMBL
774:Routes
414:e.g.,
308:ICD-10
220:(8699)
1018:InChI
932:ChEBI
636:image
326:ICD-9
168:Image
46:Notes
16:<
968:KEGG
878:UNII
383:MeSH
183:OMIM
130:Name
1064:FTP
1025:yes
1009:yes
993:yes
975:yes
957:yes
939:yes
921:yes
903:yes
885:yes
867:yes
849:yes
833:yes
815:yes
797:yes
781:yes
765:yes
747:yes
731:yes
643:yes
627:yes
451:yes
390:yes
372:yes
354:yes
333:yes
315:yes
297:yes
190:yes
175:yes
137:yes
713:no
697:no
681:,
674:no
659:no
489:^
469:no
433:no
411:no
281:no
265:no
249:no
234:no
211:no
156:no
1066:)
1049:)
1043:)
71:.
41:!
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