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247:, the Vaccine Research Center opened its doors as Building 40 on the NIH campus in 2000. The founding investigators leading the new center came from a range of scientific disciplines including virology, immunology, structural biology, bioengineering, manufacturing, clinical research and regulatory science. While HIV vaccine research and development remains a core focus, the scope of activities has expanded to include advancing scientific understanding and developing biologics for a broad array of infectious pathogens.
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553:, could potentially be used against a wide range of types and mutations of HIV in the design of a preventive HIV vaccine for human use, as well as in the formation of better antiretroviral therapy drug cocktails. The discovery, a potentially landmark one in the drive to find a vaccine for AIDS should it be validated and further improved.
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regarding research addressing HIV/AIDS. Recognizing the potential impact a vaccine could make in decreasing the global public health burden of HIV, President
Clinton in 1997 announced a plan to establish an HIV vaccine research center on the
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597:. In August 2019, Congolese health authorities, the World Health Organization, and the U.S. National Institutes of Health promoted the use of mAb114, alongside a similar
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To advance scientific understanding of infectious pathogens and develop investigational biologics, the VRC maintains programs in the following:
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880:"Director of NIAID's Vaccine Research Center Announces Retirement | NIAID: National Institute of Allergy and Infectious Diseases"
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143:. The mission of the VRC is to discover and develop both vaccines and antibody-based products that target infectious diseases.
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campus. The dedication ceremony for the VRC took place in 1999 with
President Clinton delivering the opening remarks.
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The broad research portfolio of the VRC includes basic, clinical, and translational research into vaccines for
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759:"Commencement Address at Morgan State University in Baltimore, Maryland | The American Presidency Project"
689:"Vaccine Research Center Mission and History | NIH: National Institute of Allergy and Infectious Diseases"
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The VRC is composed of an Office of the
Director, basic research laboratories and major programs.
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1048:"Protective monotherapy against lethal Ebola virus infection by a potently neutralizing antibody"
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Pandemic
Response Repository through Microbial and Immune Surveillance and Epidemiology (PREMISE)
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1023:"Adrian McDermott, M.Sc., Ph.D. | NIH: National Institute of Allergy and Infectious Diseases"
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951:"Viral Pathogenesis Laboratory | NIH: National Institute of Allergy and Infectious Diseases"
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The origins of the
Vaccine Research Center date back to 1996 following discussions between
1046:
Corti D, Misasi J, Mulangu S, Stanley DA, Kanekiyo M, Wollen S, et al. (March 2016).
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601:-produced treatment, over other treatments yielding higher mortality rates, after ending
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and has shown great success by lowering the mortality rate from 70% to about 34% in the
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and officials at the
Vaccine Research Center found that two human HIV antibodies, named
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731:"To Develop Coronavirus Treatment, Lilly Taps AbCellera Antibody Platform"
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Alphaviruses (Chikungunya, Western/Eastern/Venezuelan Equine
Encephalitis)
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1143:"A Cure for Ebola? Two New Treatments Prove Highly Effective in Congo"
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National
Institute of Arthritis and Musculoskeletal and Skin Diseases
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from the
Institut National de Recherche Biomedicale (INRB) in the
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Headquarters of Dale and Betty
Bumpers Vaccine Research Center in
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National Institute of Diabetes and Digestive and Kidney Diseases
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National Institute on Deafness and Other Communication Disorders
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Paramyxoviruses (Parainfluenza Virus and Human Metapneumovirus)
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National Institute of Allergy and Infectious Diseases (NIAID)
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National Institute on Minority Health and Health Disparities
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Vaccine antigens, antibody platforms, and routes of delivery
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National Institute of Biomedical Imaging and Bioengineering
855:"NIAID selects new director of the Vaccine Research Center"
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President George W. Bush visits the Vaccine Research Center
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Structural basis for antibody-mediated virus neutralization
1169:"Ebola is Now Curable. Here's How The New Treatments Work"
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President Joseph Biden visits the Vaccine Research Center
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President Donald Trump visits the Vaccine Research Center
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President Barack Obama visits the Vaccine Research Center
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National Center for Complementary and Integrative Health
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National Institute of Child Health and Human Development
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National Institute of Neurological Disorders and Stroke
1097:"Ebola survivor's blood holds promise of new treatment"
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National Institutes of Health Director's Pioneer Award
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National Institute of Dental and Craniofacial Research
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National Institute of Allergy and Infectious Diseases
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National Institute of Allergy and Infectious Diseases
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National Institute of Allergy and Infectious Diseases
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National Institute of Allergy and Infectious Diseases
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National Center for Advancing Translational Sciences
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National Institute of Environmental Health Sciences
581:, from a survivor from the 1995 Kikwit outbreak of
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Yeast Engineering Technology and Immunobiology Core
1289:National Institute on Alcohol Abuse and Alcoholism
374:Integrative Bioinformatics of Immune Systems Core
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783:"Dale and Betty Bumpers Vaccine Research Center"
236:Named in honor of immunization advocates former
141:US Department of Health and Human Services (HHS)
1339:National Institute of General Medical Sciences
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475:Infection and vaccine-induced immune responses
1410:National Institutes of Health Clinical Center
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1426:Advanced Research Projects Agency for Health
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737:Genetic Engineering & Biotechnology News
212:, and NIH Vaccine Research Center scientists
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589:that is being evaluated as a treatment for
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541:In July 2010, a collaboration between the
472:Disease acquisition and viral pathogenesis
340:Scientific Partnerships and Collaborations
1274:National Heart, Lung, and Blood Institute
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615:Notable visits to Vaccine Research Center
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442:Regulatory Science and Strategy Program
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831:"Nabel to Head AIDS Vaccine Institute"
807:"Building 40, Vaccine Research Center"
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386:Virus Persistence and Dynamics Section
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1572:National Institutes of Health campus
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729:Philippidis, Alex (March 16, 2020).
377:Nonhuman Primate Immunogenicity Core
131:), is an intramural division of the
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1562:United States Public Health Service
1436:National Diabetes Education Program
1344:National Institute of Mental Health
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859:National Institutes of Health (NIH)
595:2018-2020 Kivu Ebola Virus Outbreak
421:Molecular ImmunoEngineering Section
137:National Institutes of Health (NIH)
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713:"Vaccine Research Center Brochure"
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1207:Vaccine Research Center brochure
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402:Structural Bioinformatics Core
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1385:Center for Scientific Review
1364:National Library of Medicine
1167:Molteni M (12 August 2019).
571:Democratic Republic of Congo
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1284:National Institute on Aging
587:monoclonal antibody therapy
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521:Respiratory Syncytial Virus
418:Biodefense Research Section
356:Cellular Immunology Section
170:(the virus responsible for
162:, among other viruses, and
51:; 27 years ago
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451:Vaccine Production Program
448:Vaccine Immunology Program
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405:Structural Biology Section
399:Humoral Immunology Section
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1582:NIH Public Access Policy
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365:Human Immunology Section
362:The Genome Analysis Core
1494:James Augustine Shannon
1405:Vaccine Research Center
1073:10.1126/science.aad5224
763:www.presidency.ucsb.edu
439:Clinical Trials Program
396:Humoral Immunology Core
332:Office of the Director:
174:) and other pathogens.
125:Vaccine Research Center
17:Vaccine Research Center
1489:William H. Sebrell, Jr
1269:National Eye Institute
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353:Immunology Laboratory
245:Betty Flanagan Bumpers
218:President Bill Clinton
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164:therapeutic antibodies
1509:Donald S. Fredrickson
1431:Visible Human Project
605:during the outbreak.
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675:Notes and references
567:J. J. Muyembe-Tamfum
464:Key scientific areas
393:Virology Laboratory
383:Tissue Analysis Core
238:Governor of Arkansas
1514:James B. Wyngaarden
1064:2016Sci...351.1339C
591:Ebola virus disease
583:Ebola virus disease
575:monoclonal antibody
359:Flow Cytometry Core
297:Julie E. Ledgerwood
295:: Richard A. Koup,
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1638:Bethesda, Maryland
1539:Monica Bertagnolli
1147:The New York Times
1141:(12 August 2019).
368:Immunology Section
343:Strategic Planning
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1499:Robert Q. Marston
1479:Lewis R. Thompson
1464:Milton J. Rosenau
1459:Joseph J. Kinyoun
1058:(6279): 1339–42.
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1003:www.niaid.nih.gov
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955:www.niaid.nih.gov
928:www.niaid.nih.gov
901:www.niaid.nih.gov
693:www.niaid.nih.gov
314:: Ted C. Pierson
226:Dr. Anthony Fauci
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80:Parent department
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1524:Harold E. Varmus
1469:John F. Anderson
1441:BRAIN Initiative
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202:Francis Collins
187:John R. Mascola
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