1335:). The exact mechanism behind why duloxetine increases sweating is still not fully understood. However, a possible explanation is in duloxetine's action on the sympathetic nervous system. Sympathetic nerves control thermoregulation and sweating in humans; when increased levels of noradrenaline are present (as seen with SNRIs), this can stimulate sweat gland activity, leading to an increase in perspiration. Noradrenaline release may also cause increased serotonin availability that results from inhibiting reuptake enhances and further facilitates the activation of post-synaptic α-adrenoceptors by noradrenaline, which can stimulate sweat gland activity, leading to more significant amounts of copious liquid secretion mainly at higher duloxetine dosages above certain thresholds. The degree of noradrenergic "tone" determined by the interaction between noradrenergic and serotonergic neurons may determine the amount of sweating experienced; therefore, at higher doses or concentrations, serum resulting from therapeutic antidepressant treatment patients may show excess perspiration than usual as compared to low doses.
1000:, comparisons of duloxetine to other antidepressant medications have been less successful. A 2012 Cochrane Review did not find greater efficacy of duloxetine compared to SSRIs and newer antidepressants. Additionally, the review found evidence that duloxetine has increased side effects and reduced tolerability compared to other antidepressants. It thus did not recommend duloxetine as a first line treatment for major depressive disorder, given the (then) high cost of duloxetine compared to inexpensive off-patent antidepressants and lack of increased efficacy. Duloxetine appears less tolerable than some other antidepressants. Generic duloxetine became available in 2013.
1437:
incontinence (SUI). The FDA described the potential role of confounding social stressors "unclear". The suicide attempt rate in the SUI study population (based on 9,400 patients) was calculated to be 400 per 100,000 person years. This rate is greater than the suicide attempt rate among middle-aged U.S. women that has been reported in published studies, i.e., 150 to 160 per 100,000 person years. In addition, one death from suicide was reported in a
Cymbalta clinical pharmacology study in a healthy female volunteer without SUI. No increase in suicidality was reported in controlled trials of Cymbalta for depression or diabetic neuropathic pain.
51:
4429:
1692:(TKA), duloxetine is researched to provide pain relief; studies demonstrated that it can reduce pain for several weeks post-surgery without an increased risk of adverse drug events, suggesting that duloxetine could be a valuable component of a multimodal management regimen for patients undergoing THA or TKA. Also, duloxetine can reduce postoperative nausea and vomiting after THA or TKA, which are common side effects of anesthesia and opioids: this additional benefit could improve patient comfort and satisfaction, potentially enhancing recovery outcomes.
705:
682:
42:
9843:
5393:
1629:: Duloxetine is acid labile, and is formulated with enteric coating to prevent degradation in the stomach. Duloxetine has good oral bioavailability, averaging 50% after one 60 mg dose. There is an average 2-hour lag until absorption begins with maximum plasma concentrations occurring about 6 hours post dose. Food does not affect the C
988:
the CNS and while improving mean NPRS scores and achieving a ≥50% pain response in more patients compared to placebo, it has been associated with potentially serious adverse reactions including hepatotoxicity, serotonin syndrome, severe skin reactions, increased risk of bleeding, increased blood pressure and sexual dysfunction.
1296:, these were reported significantly more often than in the placebo group. In a long-term study of fibromyalgia patients receiving duloxetine, frequency and type of adverse effects was similar to that reported in the MDD trial above. Side effects tended to be mild-to-moderate, and tended to decrease in intensity over time.
965:, as a first-line therapy for fibromyalgia in the presence of mood disorders by the German Interdisciplinary Association for Pain Therapy, as a Grade B recommendation for the treatment of diabetic neuropathy by the American Association for Neurology and as a level A recommendation in certain neuropathic states by the
1602:
Duloxetine inhibits the reuptake of serotonin and norepinephrine (NE) in the central nervous system. Duloxetine increases dopamine (DA) specifically in the prefrontal cortex, where there are few DA reuptake pumps, via the inhibition of NE reuptake pumps (NET), which is believed to mediate reuptake of
1396:
When discontinuing treatment with duloxetine, the manufacturer recommends a gradual reduction in the dose, rather than abrupt cessation, whenever possible. If intolerable symptoms occur following a decrease in the dose or upon discontinuation of treatment, then resuming the previously prescribed dose
1768:
Duloxetine was approved for use of stress urinary incontinence (SUI) in the EU in 2004. In 2005, Lilly withdrew the duloxetine application for stress urinary incontinence (SUI) in the U.S., stating that discussions with the FDA indicated "the agency is not prepared at this time to grant approval ...
1747:
prolongation appeared as a concern. The FDA experts concluded that "duloxetine can cause hepatotoxicity in the form of transaminase elevations. It may also be a factor in causing more severe liver injury, but there are no cases in the NDA database that clearly demonstrate this. Use of duloxetine in
1424:
stating that antidepressants may increase the risk of suicide in persons younger than 25. This warning is based on statistical analyses conducted by two independent groups of the FDA experts that found a 2-fold increase of the suicidal ideation and behavior in children and adolescents, and 1.5-fold
1404:
In 2012 The
Institute for Safe Medical Practices (ISMP) published a report: "Duloxetine and Serious Withdrawal Symptoms". The report highlights early clinical studies which found "abrupt discontinuation showed that withdrawal effects occurred in 40-50% of patients, that 10% of those were severe and
1088:
indicated that amitriptyline, other tricyclic antidepressants and venlafaxine may be more effective. The authors noted that the evidence in favor of duloxetine is much more solid, however. A Cochrane review concluded that the evidence in support of duloxetine's efficacy in treating painful diabetic
1691:
Duloxetine is being investigated for its potential to decrease opioid use in the perioperative period because duloxetine administration can help reduce opioid consumption and mitigate the risk of opioid-related side effects and dependence. In total hip arthroplasty (THA) or total knee arthroplasty
987:
concluded that duloxetine is no better than other available agents and has a greater risk of side effects. Whereas duloxetine has shown efficacy in treating painful diabetic peripheral neuropathy by blocking late Nav 1.7 sodium ion channels and increasing norepinephrine, serotonin, and dopamine in
2365:
Bril V, England JD, Franklin GM, Backonja M, Cohen JA, Del Toro DR, et al. (June 2011). "Evidence-based guideline: treatment of painful diabetic neuropathy--report of the
American Association of Neuromuscular and Electrodiagnostic Medicine, the American Academy of Neurology, and the American
1411:
The report concluded there was insufficient information and a lack of clear warnings about the effects of discontinuing duloxetine and that in many cases withdrawal symptoms may be "severe, persistent, or both", adding "the prescribing information for physicians and pharmacists does not provide
1671:
activity and an increase in anti-inflammatory cytokines; this mechanism may apply to duloxetine in its effect on depression but research on cytokines specific to duloxetine therapy is insufficient. Cytokines are immunoregulatory molecules that play a key role in the human immune response. Some
1436:
In 2005, the United States FDA released a public health advisory noting that there had been eleven reports of suicide attempts and three reports of suicidality within the mostly middle-aged women participating in the open label extension trials of duloxetine for the treatment of stress urinary
1175:
The
National Institute for Clinical and Health Excellence recommends (as of September 2013) that duloxetine not be routinely offered as first line treatment, and that it only be offered as second line therapy in women wishing to avoid therapy. The guideline further states that women should be
1666:
Major depressive disorder is believed to be due in part to an increase in pro-inflammatory cytokines within the central nervous system. Antidepressants including ones with a similar mechanism of action as duloxetine, i.e., serotonin metabolism inhibition, cause a decrease in proinflammatory
1400:
In placebo-controlled clinical trials of up to nine weeks' duration of patients with MDD, a systematic evaluation of discontinuation symptoms in patients taking duloxetine following abrupt discontinuation found the following symptoms occurring at a rate greater than or equal to 2% and at a
1603:
DA and NE. Duloxetine has no significant affinity for dopaminergic, cholinergic, histaminergic, opioid, glutamate, and GABA reuptake transporters, however, and can therefore be considered to be a selective reuptake inhibitor at the 5-HT and NE transporters. Duloxetine undergoes extensive
5268:
1701:
5125:
Miyauchi T, Tokura T, Kimura H, Ito M, Umemura E, Sato Boku A, et al. (July 2019). "Effect of antidepressant treatment on plasma levels of neuroinflammation-associated molecules in patients with somatic symptom disorder with predominant pain around the orofacial region".
3167:"Comparison of amitriptyline supplemented with pregabalin, pregabalin supplemented with amitriptyline, and duloxetine supplemented with pregabalin for the treatment of diabetic peripheral neuropathic pain (OPTION-DM): a multicentre, double-blind, randomised crossover trial"
1163:
concluded that duloxetine decreased incontinence episodes more than placebo with people about 56% more likely than placebo to experience a 50% decrease in episodes. Adverse effects were experienced by 83% of duloxetine-treated subjects and by 45% of placebo-treated
1171:
concluded that the clinical trial data provides Grade 1a evidence that duloxetine improves but does not cure urinary incontinence, and that it causes a high rate of gastrointestinal side effects (mainly nausea and vomiting) leading to a high rate of treatment
1752:
monitoring", since there was a dose-dependant increase in elevated blood pressure readings, including at the new highest recommended dose of 120 mg "where 24% of patients had one or more blood pressure readings of 140/90 vs. 9% of placebo patients."
1081:
considered the moderate pain relief achieved with duloxetine to be clinically insignificant and the results of the clinical trials unconvincing. The reviewer saw no reason to prescribe duloxetine in practice. The comparative data collected by reviewers in
2226:"Evidence-based guideline: Treatment of painful diabetic neuropathy: report of the American Academy of Neurology, the American Association of Neuromuscular and Electrodiagnostic Medicine, and the American Academy of Physical Medicine and Rehabilitation"
1317:
are also reported. Frequency of treatment-emergent sexual dysfunction were similar for duloxetine and SSRIs when compared in a 6-month observational study in depressed patients. Rates of sexual dysfunction in MDD patients treated with duloxetine versus
1322:
did not differ significantly at 4, 8, and 12 weeks of treatment, although the trend favored duloxetine (33.3% of duloxetine patients experienced sexual side effects compared to 43.6% of those receiving escitalopram and 25% of those receiving placebo).
1308:
occurred significantly more frequently in patients treated with duloxetine than those treated with placebo, and this difference occurred only in men. Specifically, common side effects include difficulty becoming aroused, lack of interest in sex, and
1655:. Steady-state is usually achieved after 3 days. Only trace amounts (<1%) of unchanged duloxetine are present in the urine and most of the dose (approx. 70%) appears in the urine as metabolites of duloxetine with about 20% excreted in the feces.
3740:"Information for Healthcare Professionals: Duloxetine (marketed as Cymbalta) – Selective Serotonin Reuptake Inhibitors (SSRIs) or Selective Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs) and 5-Hydroxytryptamine Receptor Agonists (Triptans)"
4034:
Dueñas H, Brnabic AJ, Lee A, Montejo AL, Prakash S, Casimiro-Querubin ML, et al. (November 2011). "Treatment-emergent sexual dysfunction with SSRIs and duloxetine: effectiveness and functional outcomes over a 6-month observational period".
5272:
1672:
cytokines are proinflammatory and contribute to the development of inflammation, while others are anti-inflammatory and help to control the proinflammatory response. Duloxetine can reduce the production of pro-inflammatory cytokines such as
5089:
Maciukiewicz M, Marshe VS, Tiwari AK, Fonseka TM, Freeman N, Rotzinger S, et al. (November 2015). "Genetic variation in IL-1β, IL-2, IL-6, TSPO and BDNF and response to duloxetine or placebo treatment in major depressive disorder".
1224:(CNS) acting drugs: given the primary CNS effects of duloxetine, it should be used with caution when it is taken in combination with or substituted for other centrally acting drugs, including those with a similar mechanism of action.
1760:
warning included in the prescribing information, and the follow-up studies showed that duloxetine does not cause QTc interval prolongation, duloxetine was approved by the FDA for depression and diabetic neuropathy in 2004. In 2007,
3998:
Clayton A, Kornstein S, Prakash A, Mallinckrodt C, Wohlreich M (July 2007). "Changes in sexual functioning associated with duloxetine, escitalopram, and placebo in the treatment of patients with major depressive disorder".
5169:
Qiu W, Go KA, Wen Y, Duarte-Guterman P, Eid RS, Galea LAM (October 2021). "Maternal fluoxetine reduces hippocampal inflammation and neurogenesis in adult offspring with sex-specific effects of periadolescent oxytocin".
1688:(IL-10), however, mechanisms behind these effects are not well elucidated, there have been mixed findings regarding duloxetine's impact on cytokine production in different contexts, and the results are inconclusive.
1783:
of that in the U.S., but its patent protection terminated 1 January 2014. Lilly received a six-month extension beyond 30 June 2013, after testing for the treatment of depression in adolescents, which may produce
4459:
1089:
neuropathy was adequate, and that further trials should focus on comparisons with other medications. A crossover trial found that duloxetine, pregabalin, and amitriptyline offered similar levels of pain relief.
4542:
Bymaster FP, Lee TC, Knadler MP, Detke MJ, Iyengar S (2005). "The dual transporter inhibitor duloxetine: a review of its preclinical pharmacology, pharmacokinetic profile, and clinical results in depression".
3214:
Shkodina AD, Bardhan M, Chopra H, Anyagwa OE, Pinchuk VA, Hryn KV, et al. (March 2024). "Pharmacological and Non-pharmacological
Approaches for the Management of Neuropathic Pain in Multiple Sclerosis".
1645:: Duloxetine undergoes predominately hepatic metabolism via two cytochrome P450 isozymes, CYP2D6 and CYP1A2. Circulating metabolites are pharmacologically inactive. Duloxetine is a moderate CYP2D6 inhibitor.
6829:
1728:, assigned LY248686, was chosen for further studies, because it inhibited serotonin reuptake in rat synaptosomes to twice the degree of the (–)-enantiomer. This molecule was subsequently named duloxetine.
3349:
Citrome L, Weiss-Citrome A (January 2012). "A systematic review of duloxetine for osteoarthritic pain: what is the number needed to treat, number needed to harm, and likelihood to be helped or harmed?".
981:
review concluded that duloxetine is beneficial in the treatment of diabetic neuropathy and fibromyalgia but that more comparative studies with other medicines are needed. The French medical journal
7461:
1823:
Duloxetine moderately inhibits CYP2D6, decreasing the rate of metabolism and thereby increasing the concentration of thioridazine. This raises the patient's risk of lethal ventricular arrythmias.
5502:
5294:
Wong DT, Robertson DW, Bymaster FP, Krushinski JH, Reid LR (1988). "LY227942, an inhibitor of serotonin and norepinephrine uptake: biochemical pharmacology of a potential antidepressant drug".
4864:
Fornaro M, Rocchi G, Escelsior A, Contini P, Martino M (March 2013). "Might different cytokine trends in depressed patients receiving duloxetine indicate differential biological backgrounds".
5329:
Bymaster FP, Beedle EE, Findlay J, Gallagher PT, Krushinski JH, Mitchell S, et al. (December 2003). "Duloxetine (Cymbalta), a dual inhibitor of serotonin and norepinephrine reuptake".
3143:
5639:
4396:"Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors"
2720:
1401:
significantly higher rate in duloxetine-treated patients compared to those discontinuing from placebo: dizziness, nausea, headache, paresthesia, vomiting, irritability, and nightmare.
1077:
have better efficacy than duloxetine. Duloxetine, tricyclic antidepressants and anticonvulsants have similar tolerability while the opioids caused more side effects. Another review in
4338:
5670:
3747:
232:
6822:
1651:: Administered in healthy young male subjects at doses between 20 and 40 mg twice a day, had a half-life of 12.5 hours and its pharmacokinetics are dose proportional over the
2664:"Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis"
4496:
Stahl SM, Grady MM, Moret C, Briley M (September 2005). "SNRIs: their pharmacology, clinical efficacy, and tolerability in comparison with other classes of antidepressants".
4188:
Perahia DG, Kajdasz DK, Desaiah D, Haddad PM (December 2005). "Symptoms following abrupt discontinuation of duloxetine treatment in patients with major depressive disorder".
5476:
3870:
Chappell AS, Littlejohn G, Kajdasz DK, Scheinberg M, D'Souza DN, Moldofsky H (June 2009). "A 1-year safety and efficacy study of duloxetine in patients with fibromyalgia".
6815:
1949:
4088:
2275:"Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline"
5375:
1610:
In vitro binding studies using synaptosomal preparations isolated from rat cerebral cortex indicated that duloxetine was approximately 3 fold more potent at inhibiting
9324:
5608:
9863:
9599:
9319:
1914:
1445:
Reported adverse events that were temporally correlated to duloxetine therapy include rash, reported rarely, and the following adverse events, reported very rarely:
4110:Ĺ tuhec M (September 2015). "Excessive sweating induced by interaction between agomelatine and duloxetine hydrochloride: case report and review of the literature".
1909:[Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese).
7153:
5934:
1739:. In 2003, however, the FDA "recommended this application as not approvable from the manufacturing and control standpoint" because of "significant cGMP (current
3490:
996:
Duloxetine was approved for the treatment of major depression in 2004. While duloxetine has demonstrated improvement in depression-related symptoms compared to
9379:
7496:
5422:
3511:
3327:
2205:
187:
2564:"Update on Treating Painful Diabetic Peripheral Neuropathy: A Review of Current US Guidelines with a Focus on the Most Recently Approved Management Options"
1639:: Duloxetine is highly bound (>90%) to proteins in human plasma, binding primarily to albumin and α1-acid glycoprotein. Volume of distribution is 1640L.
1357:, there have been spontaneous reports of adverse events occurring upon discontinuation of these drugs, particularly when abrupt, including the following:
3668:
829:
5506:
4225:"Antidepressants and Suicidality in Adults: Statistical Evaluation. (Presentation at Psychopharmacologic Drugs Advisory Committee; December 13, 2006)"
3579:
Li J, Yang L, Pu C, Tang Y, Yun H, Han P (June 2013). "The role of duloxetine in stress urinary incontinence: a systematic review and meta-analysis".
771:
245:
9873:
9589:
9574:
4699:
Fric M, Pfuhlmann B, Laux G, Riederer P, Distler G, Artmann S, et al. (July 2008). "The influence of smoking on the serum level of duloxetine".
4313:
4272:
3444:
3395:"The efficacy of duloxetine, non-steroidal anti-inflammatory drugs, and opioids in osteoarthritis: a systematic literature review and meta-analysis"
1276:
In a trial for major depressive disorder (MDD), the most commonly reported treatment-emergent adverse events among duloxetine-treated patients were
5820:
4234:
1093:
of duloxetine and pregabalin offered additional pain relief for people whose pain is not adequately controlled with one medication, and was safe.
9521:
6861:
5901:
1354:
881:
180:
3118:
1152:
The safety and utility of duloxetine in the treatment of incontinence has been evaluated in a series of meta analyses and practice guidelines.
3622:
5647:
5042:"Clinical effect of flunarizine combined with duloxetine in the treatment of chronic migraine comorbidity of depression and anxiety disorder"
2712:
2540:
966:
73:
4350:
3739:
9441:
8983:
8978:
8259:
8254:
8073:
6716:
5967:
5678:
1193:
Hypersensitivity: duloxetine is contraindicated in patients with a known hypersensitivity to duloxetine or any of the inactive ingredients.
785:
3285:
2922:"A double-blind, randomized multicenter trial comparing duloxetine with placebo in the management of diabetic peripheral neuropathic pain"
7146:
895:, nausea, feeling tired, dizziness, agitation, sexual problems, and increased sweating. Severe side effects include an increased risk of
4821:
Kim YK, Na KS, Shin KH, Jung HY, Choi SH, Kim JB (June 2007). "Cytokine imbalance in the pathophysiology of major depressive disorder".
3646:
2025:
1987:
1743:) violations at the finished product manufacturing facility" of Eli Lilly in Indianapolis. Additionally, "potential liver toxicity" and
8762:
1133:(FDA) approved duloxetine to treat chronic musculoskeletal pain, including discomfort from osteoarthritis and chronic lower back pain.
5218:"Duloxetine reduces opioid consumption and pain after total hip or knee arthroplasty: a meta-analysis of randomized controlled trials"
3532:"Considering benefits and harms of duloxetine for treatment of stress urinary incontinence: a meta-analysis of clinical study reports"
1408:
Withdrawal symptoms listed in 48 case reports (in the first quarter of 2012) included anger, crying, dizziness and suicidal ideation.
9359:
9100:
7491:
7486:
5718:
2877:
Goldstein DJ, Lu Y, Detke MJ, Lee TC, Iyengar S (July 2005). "Duloxetine vs. placebo in patients with painful diabetic neuropathy".
9484:
5444:
1433:
and behavior in clinical trials are rare, the results for any drug taken separately usually do not reach statistical significance.
5480:
4153:
Demling J, Beyer S, Kornhuber J (January 2010). "To sweat or not to sweat? A hypothesis on the effects of venlafaxine and SSRIs".
1057:
The comparative efficacy of duloxetine and established pain-relief medications for DPN is unclear. A systematic review noted that
1050:(DPN) by the US FDA. The response is achieved in the first two weeks on the medication. Duloxetine slightly increased the fasting
5762:
1855:
1108:
A review of duloxetine found that it reduced pain and fatigue, and improved physical and mental performance compared to placebo.
885:
4742:
1941:
7481:
7139:
5364:
4372:
4078:
1350:
3769:
Ma J, Björnsson ES, Chalasani N (February 2024). "The Safe Use of
Analgesics in Patients with Cirrhosis: A Narrative Review".
6773:
4453:
2159:
2072:
962:
5616:
1906:
1748:
the presence of ethanol may potentiate the deleterious effect of ethanol on the liver." The FDA also recommended "routine
9514:
9468:
6000:
2102:
813:
InChI=1S/C18H19NOS/c1-19-12-11-17(18-10-5-13-21-18)20-16-9-4-7-14-6-2-3-8-15(14)16/h2-10,13,17,19H,11-12H2,1H3/t17-/m0/s1
3948:"The safety and tolerability of duloxetine compared with paroxetine and placebo: a pooled analysis of 4 clinical trials"
7834:
5868:
4901:"The effect of newer serotonin-noradrenalin antidepressants on cytokine production: a review of the current literature"
4656:
Knadler MP, Lobo E, Chappell J, Bergstrom R (May 2011). "Duloxetine: clinical pharmacokinetics and drug interactions".
1235:
In addition, the FDA has reported on life-threatening drug interactions that may be possible when co-administered with
912:
4443:
1769:
based on the data package submitted." A year later Lilly abandoned the pursuit of this indication in the U.S. market.
836:
124:
3924:
3478:
2135:
922:
Duloxetine was approved for medical use in the United States and in the
European Union in 2004. It is available as a
862:
805:
4631:
2742:
Carter NJ, McCormack PL (2009). "Duloxetine: a review of its use in the treatment of generalized anxiety disorder".
9283:
6790:
5585:
5410:
3315:
1168:
383:
217:
105:
9507:
9488:
4950:"The Effect of Antidepressant Medication Treatment on Serum Levels of Inflammatory Cytokines: A Meta-Analysis"
2793:(11): ITC6–1, ITC6–2, ITC6–3, ITC6–4, ITC6–5, ITC6–6, ITC6–7, ITC6–8, ITC6–9, ITC6–10, ITC6–11, quiz ITC6–12.
1149:, however, where it is recommended as an add-on medication in stress urinary incontinence instead of surgery.
8544:
6906:
5711:
4394:
Bymaster FP, Dreshfield-Ahmad LJ, Threlkeld PG, Shaw JL, Thompson L, Nelson DL, et al. (December 2001).
1907:"RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial"
1390:
1344:
470:
3664:
1397:
may be considered. Subsequently, the physician may continue decreasing the dose but at a more gradual rate.
961:
Duloxetine is recommended as a first-line agent for the treatment of chemotherapy-induced neuropathy by the
9464:
7181:
7162:
5449:
5416:
5371:
4344:
4309:
4268:
4229:
3743:
3484:
3456:
3450:
3321:
2968:
1910:
1736:
1490:
1130:
1112:
1009:
943:
858:
700:
521:
4298:
4257:
3068:"Duloxetine for painful diabetic neuropathy and fibromyalgia pain: systematic review of randomised trials"
622:
8828:
8104:
6373:
6306:
1878:"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)"
1792:
1740:
1611:
1429:
results the FDA combined the results of 295 trials of 11 antidepressants for psychiatric indications. As
1214:(dilation of the pupil); therefore, its use should be avoided in patients with uncontrolled narrow-angle
1196:
1014:
661:
4224:
2273:
Hershman DL, Lacchetti C, Dworkin RH, Lavoie Smith EM, Bleeker J, Cavaletti G, et al. (June 2014).
9868:
9833:
7823:
7335:
6136:
6044:
1607:, but the major circulating metabolites do not contribute significantly to the pharmacologic activity.
1542:
1462:
614:
6807:
2954:
926:. In 2022, it was the 31st most commonly prescribed medication in the United States, with more than 18
9888:
6987:
6880:
6148:
5578:"FDA approves antidepressant Cymbalta (duloxetine HCl) for treatment of generalized anxiety disorder"
2961:
2019:
1981:
1877:
1426:
1405:
approximately half were not resolved when side effects monitoring had ended after one or two weeks".
939:
854:
24:
4428:
9893:
9883:
7064:
5704:
3629:
1446:
1058:
677:
2520:
9301:
6778:
3690:
Derby MA, Zhang L, Chappell JC, Gonzales CR, Callaghan JT, Leibowitz M, et al. (June 2007).
1804:
1486:
1412:
realistic schedules for tapering or a clear picture of the likely incidence of these reactions".
978:
161:
63:
2662:
Cipriani A, Furukawa TA, Salanti G, Chaimani A, Atkinson LZ, Ogawa Y, et al. (April 2018).
1772:
The FDA approved duloxetine for the treatment of generalized anxiety disorder in
February 2007.
9480:
9476:
8883:
8159:
7589:
7542:
6613:
6084:
4743:"Duloxetine 60mg gastro-resistant capsules - Summary of Product Characteristics (SmPC) - (emc)"
3293:
1221:
643:
322:
2830:"Pharmacological and Nonpharmacological Treatments for Painful Diabetic Peripheral Neuropathy"
2613:
Cipriani A, Koesters M, Furukawa TA, Nosè M, Purgato M, Omori IM, et al. (October 2012).
1765:
approved duloxetine for the treatment of depression and diabetic peripheral neuropathic pain.
594:
586:
50:
9780:
9700:
9594:
9530:
8601:
8533:
8007:
7309:
6054:
3650:
2798:
2014:
1976:
1709:
1677:
1532:
1156:
A 2017 meta-analysis found that harms are at least as great if not greater than the benefits.
1047:
874:
461:
4899:
De
Berardis D, Conti CM, Serroni N, Moschetta FS, Olivieri L, Carano A, et al. (2010).
3039:"Duloxetine: new indication. Depression and diabetic neuropathy: too many adverse effects".
1313:(trouble achieving orgasm). Loss of or decreased response to sexual stimuli and ejaculatory
425:
417:
9472:
9344:
8873:
8417:
8149:
7579:
7558:
7170:
6733:
6648:
2419:
Attal N, Cruccu G, Baron R, Haanpää M, Hansson P, Jensen TS, et al. (September 2010).
1732:
1552:
1450:
1145:
amid concerns over liver toxicity and suicidal events; it was approved for this use in the
951:
538:
530:
510:
352:
8:
9878:
9158:
9003:
8868:
8596:
8453:
8279:
8144:
7799:
7574:
6930:
6845:
6559:
6499:
5454:
3165:
Tesfaye S, Sloan G, Petrie J, White D, Bradburn M, Julious S, et al. (August 2022).
2224:
Bril V, England J, Franklin GM, Backonja M, Cohen J, Del Toro D, et al. (May 2011).
1458:
1142:
1090:
408:
168:
5244:
5217:
2920:
Raskin J, Pritchett YL, Wang F, D'Souza DN, Waninger AL, Iyengar S, et al. (2005).
2854:
2829:
2590:
2563:
2497:
2472:
704:
681:
9549:
9541:
9243:
7269:
5750:
5746:
5195:
5151:
5066:
5041:
5022:
4974:
4949:
4930:
4846:
4798:
4773:
4724:
4681:
4596:
4579:
4521:
4306:
Overview for
December 13 Meeting of Psychopharmacologic Drugs Advisory Committee (PDAC)
4265:
Overview for December 13 Meeting of Psychopharmacologic Drugs Advisory Committee (PDAC)
4135:
4060:
3972:
3947:
3895:
3847:
3822:
3794:
3721:
3604:
3556:
3531:
3421:
3394:
3375:
3191:
3166:
3135:
3094:
3067:
3016:
2991:
2902:
2810:
2767:
2688:
2663:
2639:
2614:
2450:
2401:
2347:
2304:
2250:
2225:
1717:
1673:
1494:
1305:
1240:
1097:
923:
900:
135:
5554:
5529:
5365:
Approval package for: application number NDA 721-427. Administrative/Correspondence #2
4412:
4395:
4258:"Clinical review: relationship between antidepressant drugs and suicidality in adults"
3811:
Cymbalta package insert. Indianapolis, IN: Eli Lilly Pharmaceuticals; 2004, September.
3692:"The effects of supratherapeutic doses of duloxetine on blood pressure and pulse rate"
3182:
2992:"Effects of treatments for symptoms of painful diabetic neuropathy: systematic review"
2679:
2322:
Sommer C, Häuser W, Alten R, Petzke F, Späth M, Tölle T, et al. (June 2012). "".
1847:
9559:
9234:
7972:
7679:
7254:
7036:
7026:
6750:
6652:
6171:
5559:
5346:
5311:
5307:
5249:
5199:
5187:
5155:
5143:
5107:
5071:
5014:
4979:
4922:
4881:
4838:
4803:
4750:
4716:
4685:
4673:
4669:
4601:
4560:
4513:
4449:
4417:
4205:
4170:
4139:
4127:
4052:
4016:
4012:
3977:
3887:
3852:
3838:
3798:
3786:
3713:
3596:
3561:
3426:
3367:
3267:
3232:
3196:
3139:
3099:
3048:
3021:
2943:
2938:
2921:
2894:
2859:
2802:
2759:
2755:
2693:
2644:
2595:
2532:
2502:
2442:
2437:
2421:"EFNS guidelines on the pharmacological treatment of neuropathic pain: 2010 revision"
2420:
2393:
2339:
2296:
2255:
2131:
1652:
1430:
1421:
633:
269:
257:
97:
4850:
4728:
4525:
4380:
4064:
3899:
3608:
3379:
2906:
2814:
2771:
2454:
2405:
2308:
888:, the precise mechanism for its antidepressant and anxiolytic effects is not known.
9815:
9579:
9569:
9564:
9339:
9194:
8566:
7962:
7659:
7599:
7416:
7330:
7072:
6972:
6838:
6723:
6666:
6602:
6449:
5549:
5541:
5338:
5303:
5239:
5229:
5179:
5135:
5099:
5061:
5053:
5026:
5006:
4969:
4961:
4912:
4873:
4830:
4793:
4789:
4785:
4708:
4665:
4591:
4552:
4505:
4407:
4197:
4162:
4119:
4044:
4008:
3967:
3959:
3879:
3842:
3834:
3778:
3725:
3703:
3588:
3551:
3543:
3416:
3406:
3359:
3263:
3259:
3224:
3186:
3178:
3127:
3089:
3079:
3011:
3003:
2933:
2886:
2849:
2841:
2794:
2751:
2683:
2675:
2634:
2630:
2626:
2585:
2575:
2492:
2488:
2484:
2432:
2383:
2375:
2351:
2331:
2286:
2245:
2237:
1633:
of duloxetine, but delays the time to reach peak concentration from 6 to 10 hours.
1186:
947:
870:
717:
304:
200:
4934:
4580:"Duloxetine, an antidepressant with analgesic properties - a preliminary analysis"
3823:"Duloxetine 60 mg once daily in the treatment of milder major depressive disorder"
2181:
2151:
2064:
1720:
filed in 1986 and granted in 1990. The first publication on the discovery of the
450:
83:
9847:
9309:
9184:
9126:
9114:
8782:
8421:
8053:
7987:
7401:
7289:
7264:
7050:
6662:
6656:
6469:
5843:
4048:
3883:
3782:
3708:
3691:
3393:
Myers J, Wielage RC, Han B, Price K, Gahn J, Paget MA, et al. (March 2014).
2241:
1575:
1562:
1386:
1207:
332:
312:
7131:
5731:
4834:
3946:
Nelson JC, Lu Pritchett Y, Martynov O, Yu JY, Mallinckrodt CH, Detke MJ (2006).
3007:
9710:
9138:
9122:
9118:
9044:
8767:
8433:
8425:
8038:
7804:
7527:
7279:
7116:
6938:
6784:
6226:
5935:
5833:
5727:
5640:"Eli Lilly to lay off hundreds in sales as Cymbalta nears edge of patent cliff"
5342:
5234:
4917:
4900:
4166:
3437:
3228:
3131:
2890:
1757:
1749:
1685:
1615:
1588:
1474:
1146:
1123:
1070:
908:
5545:
5183:
4877:
4509:
4365:
4299:"Statistical Evaluation of Suicidality in Adults Treated with Antidepressants"
4201:
4123:
3592:
3455:(Press release). Food and Drug Administration. 4 November 2010. Archived from
2335:
2094:
1684:(IL-6) and may increase the production of anti-inflammatory cytokines such as
9857:
9604:
9584:
9554:
9394:
9178:
9174:
9144:
9110:
9084:
9074:
9029:
8993:
8853:
8797:
8636:
8576:
8498:
8478:
8461:
8439:
8360:
8355:
8305:
8269:
8129:
8068:
7794:
7314:
7299:
7259:
7102:
7000:
6996:
6958:
6954:
6893:
6889:
6853:
6674:
6621:
6409:
6281:
6256:
6251:
6191:
6166:
5397:
5010:
4556:
4485:(4th ed.). New York: Cambridge University Press. pp. 305, 308, 309.
3363:
2291:
2274:
1762:
1681:
1370:
1332:
1160:
1084:
1066:
1051:
693:
282:
16:
Antidepressant medication used also for treatment of anxiety and chronic pain
7411:
7406:
3639:
3411:
9690:
9635:
9329:
9224:
9214:
9039:
9034:
8878:
8848:
8736:
8606:
8484:
8396:
8365:
8320:
8315:
8310:
8154:
8124:
8012:
7921:
7881:
7784:
7704:
7594:
7584:
7396:
7391:
7376:
7371:
7350:
7031:
6842:
6719:
6707:
6617:
6524:
6454:
6444:
6296:
6286:
6186:
6181:
6104:
6099:
6079:
6064:
6018:
5780:
5744:
5563:
5350:
5253:
5191:
5147:
5111:
5075:
5018:
4983:
4926:
4885:
4842:
4807:
4720:
4712:
4677:
4605:
4564:
4517:
4421:
4339:"Historical Information on Duloxetine hydrochloride (marketed as Cymbalta)"
4209:
4174:
4131:
4056:
4020:
3981:
3891:
3856:
3790:
3717:
3600:
3565:
3430:
3371:
3271:
3236:
3200:
3119:"Combination therapy for painful diabetic neuropathy is safe and effective"
3103:
3084:
3052:
3025:
2947:
2898:
2863:
2806:
2763:
2697:
2648:
2599:
2536:
2506:
2446:
2397:
2343:
2300:
2259:
1791:
The first generic duloxetine was marketed by Indian pharmaceutical company
1478:
1454:
1362:
1319:
1270:
1246:
Duloxetine should also be avoided in hepatic impairment such as cirrhosis.
1239:
and other drugs acting on serotonin pathways leading to increased risk for
1228:
1119:
1023:
955:
915:
may occur if stopped. There are concerns that use during the later part of
866:
195:
33:
8689:
Selective serotonin reuptake inhibitors and serotonin receptor modulators:
5315:
3916:
2845:
2473:"Duloxetine for treating painful neuropathy, chronic pain or fibromyalgia"
9775:
9695:
9645:
9538:
9399:
9389:
9334:
9305:
9255:
9199:
9152:
9134:
9069:
9049:
8998:
8988:
8963:
8923:
8918:
8863:
8833:
8812:
8802:
8792:
8752:
8691:
8671:
8661:
8641:
8621:
8581:
8571:
8518:
8447:
8429:
8401:
8386:
8345:
8325:
8274:
8264:
8239:
8199:
8194:
8139:
8109:
8088:
8078:
8063:
8028:
7992:
7957:
7886:
7876:
7866:
7861:
7809:
7789:
7779:
7754:
7734:
7664:
7639:
7614:
7609:
7604:
7569:
7564:
7522:
7517:
7466:
7274:
7086:
7046:
7004:
6966:
6950:
6874:
6637:
6534:
6399:
6334:
6329:
6319:
6276:
6261:
6246:
6236:
6206:
6196:
6069:
6039:
6034:
5980:
5957:
5952:
5924:
5881:
5858:
5848:
5790:
5696:
4965:
4624:
4083:
3963:
2388:
1744:
1035:
91:
9499:
5577:
5411:"Drug Approval Package: Cymbalta (Duloxetine Hydrochloride) NDA #021427"
3911:
3909:
3547:
3516:
3479:"Drug Approval Package: Cymbalta (duloxetine hydrochloride) NDA #022516"
3316:"Drug Approval Package: Cymbalta (duloxetine hydrochloride) NDA #022148"
3250:
Acuna C (October 2008). "Duloxetine for the treatment of fibromyalgia".
2580:
2210:
1115:(FDA) approved the drug for the treatment of fibromyalgia in June 2008.
490:
9820:
9760:
9735:
9685:
9680:
9625:
9448:
9404:
9369:
9296:
9259:
9219:
9189:
9166:
9130:
9079:
9064:
8948:
8933:
8903:
8893:
8888:
8843:
8838:
8777:
8757:
8731:
8701:
8696:
8681:
8676:
8651:
8646:
8616:
8611:
8591:
8586:
8510:
8489:
8472:
8467:
8350:
8340:
8224:
8209:
8179:
8169:
8164:
8119:
8114:
8048:
8002:
7982:
7967:
7942:
7926:
7901:
7896:
7774:
7764:
7749:
7694:
7684:
7674:
7654:
7644:
7629:
7624:
7547:
7537:
7532:
7345:
7238:
7233:
7110:
7054:
7010:
6982:
6962:
6946:
6942:
6915:
6837:
6755:
6741:
6727:
6633:
6629:
6625:
6579:
6549:
6544:
6539:
6519:
6489:
6479:
6439:
6424:
6404:
6291:
6271:
6241:
6221:
6201:
6161:
6109:
6094:
6089:
6049:
6013:
5985:
5914:
5891:
5886:
5810:
5805:
5800:
5785:
5775:
5103:
1725:
1713:
1604:
1420:
In the United States all antidepressants, including duloxetine carry a
1310:
1258:
1096:
Duloxetine is also an option for the management of neuropathic pain in
1062:
1031:
1027:
1019:
892:
747:
501:
175:
20:
5269:"United States Patent 4,956,388: 3-Aryloxy-3-substituted propanamines"
5057:
2379:
1971:
1969:
1967:
9805:
9795:
9755:
9725:
9715:
9655:
9436:
9384:
9354:
9349:
9269:
9251:
9247:
9204:
9162:
9105:
9054:
8973:
8943:
8807:
8726:
8716:
8711:
8706:
8631:
8626:
8506:
8502:
8391:
8381:
8330:
8249:
8219:
8083:
8033:
7952:
7947:
7916:
7911:
7871:
7769:
7759:
7724:
7649:
7619:
7552:
7512:
7476:
7381:
7366:
7340:
7304:
7294:
7223:
7218:
7213:
7208:
7098:
7094:
7076:
7041:
6976:
6897:
6643:
6529:
6464:
6459:
6434:
6429:
6419:
6414:
6324:
6266:
6231:
6211:
6176:
6132:
5990:
5947:
5919:
5853:
5795:
5139:
4393:
3906:
2785:
Patel G, Fancher TL (December 2013). "Generalized anxiety disorder".
1498:
1466:
1378:
1366:
1358:
1314:
1289:
1281:
1266:
1211:
1199:(MAOIs): concomitant use in patients taking MAOIs is contraindicated.
983:
916:
436:
365:
77:
5968:
5821:
2272:
2211:
Clinical guideline 96: Neuropathic pain – pharmacological management
1369:
electric shock sensations), anxiety, confusion, headache, lethargy,
9810:
9800:
9785:
9750:
9730:
9705:
9670:
9650:
9423:
9374:
9364:
9263:
9209:
9170:
9148:
8938:
8928:
8721:
8514:
8457:
8443:
8214:
8204:
7906:
7891:
7856:
7714:
7709:
7699:
7669:
7471:
7228:
7106:
7090:
7068:
7058:
6919:
6862:
6394:
6350:
6074:
6059:
5902:
5530:"FDA warns that antidepressants may increase suicidality in adults"
3997:
3869:
1964:
1668:
1658:
Smoking is associated with a decrease in duloxetine concentration.
1482:
1470:
1382:
1374:
1293:
1285:
1262:
1215:
1203:
566:
558:
481:
119:
1361:, irritability, agitation, dizziness, sensory disturbances (e.g.,
770:
649:
9765:
9745:
9740:
9720:
9675:
9665:
9640:
9620:
9229:
9059:
9012:
9008:
8958:
8953:
8908:
8898:
8858:
8787:
8666:
8335:
8288:
8284:
8234:
8229:
8184:
8174:
8134:
8058:
7977:
7739:
7729:
7719:
7689:
7634:
7456:
7451:
7446:
7441:
7436:
7431:
7426:
7386:
7284:
7203:
6216:
5396:
This article incorporates text from this source, which is in the
3821:
Perahia DG, Kajdasz DK, Walker DJ, Raskin J, Tylee A (May 2006).
1721:
1236:
1018:
lists duloxetine among the first line drug treatments along with
997:
896:
4997:
Opal SM, DePalo VA (April 2000). "Anti-inflammatory cytokines".
4898:
3471:
3308:
2087:
1724:
form of duloxetine known as LY227942, was made in 1988. The (+)-
1304:
In four clinical trials of duloxetine for the treatment of MDD,
9770:
9630:
9239:
8968:
8913:
8656:
8494:
8244:
8189:
7997:
7744:
7421:
7082:
6903:
5940:
Tooltip Noradrenergic and specific serotonergic antidepressants
5763:
5293:
5088:
3917:"Cymbalta - FDA prescribing information, side effects and uses"
2661:
2615:"Duloxetine versus other anti-depressive agents for depression"
1842:
1840:
1700:
1277:
1254:
1074:
605:
345:
341:
5328:
4735:
2919:
2182:"Duloxetine Drug Usage Statistics, United States, 2013 - 2022"
1046:
Duloxetine was approved for the pain associated with diabetic
1008:
Duloxetine is more effective than placebo in the treatment of
399:-Methyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine
9790:
6131:
4863:
2130:(76 ed.). Pharmaceutical Press. 2018. pp. 364–365.
1942:"Cymbalta- duloxetine hydrochloride capsule, delayed release"
1712:
researchers. David Robertson; David Wong, a co-discoverer of
904:
761:
577:
337:
41:
4655:
3952:
Primary Care Companion to the Journal of Clinical Psychiatry
3945:
3805:
3213:
2612:
1837:
666:
9313:
6001:
4187:
3445:"FDA clears Cymbalta to treat chronic musculoskeletal pain"
2364:
2223:
2122:
2120:
1899:
549:
7835:
5869:
5267:
Robertson DW, Wong DT, Krushinski JH (11 September 1990).
4619:
4617:
4615:
3820:
3689:
3657:
3286:"FDA Approves Cymbalta for the Management of Fibromyalgia"
1425:
increase of suicidality in the 18–24 age group. To obtain
4905:
International Journal of Immunopathology and Pharmacology
4698:
1885:
972:
9284:
4947:
4037:
International Journal of Psychiatry in Clinical Practice
2117:
1210:, Cymbalta use was associated with an increased risk of
5266:
5168:
5124:
4612:
4541:
4033:
3164:
3065:
2418:
2321:
1716:; and Joseph Krushinski are listed as inventors on the
8826:
Serotonin–norepinephrine–dopamine reuptake inhibitors:
8102:
Serotonin–norepinephrine–dopamine reuptake inhibitors:
3066:
Sultan A, Gaskell H, Derry S, Moore RA (August 2008).
1167:
A 2012 review and practice guideline published by the
9831:
8545:
6907:
5609:"Lilly could net $ 1.5B-plus from Cymbalta extension"
4495:
4445:
Top Drugs: Their History, Pharmacology, and Syntheses
4152:
4071:
3512:
National Institute for Health and Clinical Excellence
3278:
2521:"Towards better patient care: drugs to avoid in 2014"
2206:
National Institute for Health and Clinical Excellence
2071:. The American Society of Health-System Pharmacists.
7182:
5973:
Tooltip Serotonin antagonist and reuptake inhibitors
5826:
Tooltip Serotonin–norepinephrine reuptake inhibitors
4948:
Hannestad J, DellaGioia N, Bloch M (November 2011).
4079:"Duloxetine (Oral Route) Side Effects - Mayo Clinic"
3768:
3392:
3348:
2713:"Loss of Cymbalta patent a major blow for Eli Lilly"
2366:
Academy of Physical Medicine & Rehabilitation".
1331:
Duloxetine may also cause sweating more than usual (
6867:
Tooltip Serotonin–norepinephrine reuptake inhibitor
6307:
5907:
Tooltip Norepinephrine–dopamine reuptake inhibitors
5216:Lin Y, Jiang M, Liao C, Wu Q, Zhao J (March 2024).
2876:
2561:
1870:
469:
7824:
5495:
5469:
4584:Romanian Journal of Anaesthesia and Intensive Care
3529:
3117:
1756:After the manufacturing issues were resolved, the
7161:
6988:
6881:
6149:
5570:
9855:
6372:
4373:"Duloxetine Side Effects, and Drug Interactions"
3530:Maund E, Guski LS, Gøtzsche PC (February 2017).
2470:
1218:, in which mydriasis can cause sudden worsening.
1103:
449:
6709:
5768:Tooltip Selective serotonin reuptake inhibitors
5671:"Generic Cheaper Versions of Cymbalta Approved"
5505:TheStreet.com. 15 February 2006. Archived from
5211:
5209:
4537:
4535:
4296:
3993:
3991:
2741:
2466:
2464:
2009:
2007:
2005:
1936:
1934:
1932:
1003:
424:
416:
5260:
5215:
4331:
2962:"Application number 21-733. Medical review(s)"
2471:Lunn MP, Hughes RA, Wiffen PJ (January 2014).
1136:
9515:
8750:Serotonin–norepinephrine reuptake inhibitors:
8534:
8026:Serotonin–norepinephrine reuptake inhibitors:
7854:Selective norepinephrine reuptake inhibitors:
7147:
7118:
6823:
5712:
5437:
4820:
4774:"Inflammatory cytokine-associated depression"
4290:
3292:(Press release). 16 June 2008. Archived from
3110:
2989:
1497:(especially at initiation of treatment), and
1489:(especially at the initiation of treatment),
1141:Duloxetine failed to receive US approval for
967:European Federation of Neurological Societies
9864:Serotonin–norepinephrine reuptake inhibitors
7940:Norepinephrine–dopamine reuptake inhibitors:
7171:
5631:
5600:
5521:
5331:Bioorganic & Medicinal Chemistry Letters
5322:
5206:
5162:
5118:
5082:
5039:
5033:
4990:
4941:
4892:
4857:
4814:
4765:
4692:
4649:
4571:
4532:
4489:
4387:
4181:
4146:
4103:
4027:
3988:
3939:
3863:
3814:
3762:
3683:
3578:
3572:
3523:
3505:
3386:
3342:
3243:
3207:
3158:
3059:
3032:
2983:
2913:
2870:
2821:
2784:
2778:
2735:
2704:
2655:
2606:
2555:
2513:
2461:
2412:
2358:
2315:
2266:
2217:
2002:
1929:
1273:, reported by about 10% to 20% of patients.
1176:counseled regarding the drug's side effects.
991:
853:among others, is a medication used to treat
123:
6743:
6560:
6500:
6006:Tooltip Serotonin modulator and stimulators
5662:
5479:. Health Canada. 5 May 2008. Archived from
5477:"Summary Basis of Decision (SBD): Cymbalta"
5287:
4222:
3615:
3517:Clinical guideline 40: Urinary incontinence
2619:The Cochrane Database of Systematic Reviews
2477:The Cochrane Database of Systematic Reviews
1338:
882:serotonin–norepinephrine reuptake inhibitor
181:Serotonin–norepinephrine reuptake inhibitor
9522:
9508:
7840:Tooltip Norepinephrine reuptake inhibitors
7154:
7140:
6830:
6816:
5874:Tooltip Norepinephrine reuptake inhibitors
5726:
5719:
5705:
4996:
4474:
4297:Levenson M, Holland C (17 November 2006).
4255:
4249:
3827:International Journal of Clinical Practice
2059:
2057:
2055:
2053:
2051:
2049:
2047:
2045:
2043:
703:
680:
509:
49:
40:
9529:
5553:
5243:
5233:
5065:
4973:
4916:
4823:Prog Neuropsychopharmacol Biol Psychiatry
4797:
4595:
4411:
3971:
3846:
3707:
3647:"Urinary incontinence Introduction CG171"
3555:
3420:
3410:
3190:
3093:
3083:
3015:
2937:
2853:
2687:
2638:
2589:
2579:
2496:
2436:
2387:
2290:
2249:
2199:
1913:(published 4 April 2023). 31 March 2023.
537:
529:
9874:Drugs developed by Eli Lilly and Company
9289:Tooltip Vesicular monoamine transporters
8564:Selective serotonin reuptake inhibitors:
6601:
5403:
5357:
4216:
3732:
2990:Wong MC, Chung JW, Wong TK (July 2007).
2799:10.7326/0003-4819-159-11-201312030-01006
2128:British national formulary : BNF 76
1699:
1440:
4771:
4435:
4256:Stone MB, Jones ML (17 November 2006).
2710:
2040:
1389:syndrome from duloxetine resembles the
676:
489:
96:
9856:
5637:
5606:
5527:
5503:"Lilly Won't Pursue Yentreve for U.S."
5425:from the original on 24 September 2020
5040:Zhu J, Chen J, Zhang K (August 2022).
4237:from the original on 27 September 2007
4109:
3927:from the original on 14 September 2018
3696:Journal of Cardiovascular Pharmacology
2827:
2028:from the original on 24 September 2020
1858:from the original on 29 September 2018
1661:
1509:
973:Painful diabetic peripheral neuropathy
694:
291:
263:
9503:
8550:Tooltip Serotonin reuptake inhibitors
7135:
6912:Tooltip monoamine reuptake inhibitors
6811:
6696:
6600:
6371:
6130:
5743:
5700:
5668:
5381:from the original on 12 February 2017
4577:
4480:
4462:from the original on 25 February 2024
3249:
2075:from the original on 26 November 2018
1817:
1326:
1299:
963:American Society of Clinical Oncology
642:
621:
613:
593:
585:
276:
114:
82:
7187:Tooltip Dopamine reuptake inhibitors
5588:from the original on 15 January 2009
4637:from the original on 31 October 2005
4091:from the original on 19 October 2023
3581:International Urology and Nephrology
3330:from the original on 31 October 2020
2723:from the original on 15 January 2014
2105:from the original on 27 January 2024
1990:from the original on 20 October 2020
1810:
1180:
648:
199:
68:Cymbalta, Ariclaim, Yentreve, others
6312:Tooltip Tetracyclic antidepressants
2562:Mallick-Searle T, Adler JA (2024).
2162:from the original on 30 August 2024
1952:from the original on 13 August 2020
1775:Cymbalta generated sales of nearly
1621:
1041:
938:The main uses of duloxetine are in
793:CNCC(C1=CC=CS1)OC2=CC=CC3=CC=CC=C32
565:
557:
440:
13:
8884:Didesmethylsibutramine (BTS-54505)
8160:Didesmethylsibutramine (BTS-54505)
7829:Tooltip Norepinephrine transporter
7590:Didesmethylsibutramine (BTS-54505)
4441:
4319:from the original on 16 March 2007
4278:from the original on 16 March 2007
3671:from the original on 13 April 2010
3146:from the original on 28 April 2023
1917:from the original on 3 August 2023
1249:
913:Antidepressant withdrawal syndrome
886:Similarly to SSRIs and other SNRIs
14:
9905:
7402:Etybenzatropine (ethybenztropine)
6993:Tooltip Tricyclic antidepressants
6886:Tooltip Tricyclic antidepressants
6697:
6154:Tooltip Tricyclic antidepressants
3750:from the original on 7 March 2013
3493:from the original on 5 April 2021
2543:from the original on 14 July 2014
1735:(NDA) for duloxetine with the US
226:
146:
9841:
8874:Desmethylsibutramine (BTS-54354)
8150:Desmethylsibutramine (BTS-54354)
7580:Desmethylsibutramine (BTS-54354)
5391:
4670:10.2165/11539240-000000000-00000
4427:
4013:10.1111/j.1743-6109.2007.00520.x
3839:10.1111/j.1368-5031.2006.00956.x
2939:10.1111/j.1526-4637.2005.00061.x
2828:Jang HN, Oh TJ (November 2023).
2756:10.2165/00023210-200923060-00006
2438:10.1111/j.1468-1331.2010.02999.x
1189:are listed by the manufacturer:
734:
728:
9485:Monoamine metabolism modulators
2174:
2144:
1504:
1169:European Association of Urology
933:
919:can harm the developing fetus.
818:Key:ZEUITGRIYCTCEM-KRWDZBQOSA-N
4790:10.1016/j.brainres.2014.06.032
4483:Stahl's Essential Pharmacology
4190:Journal of Affective Disorders
4001:The Journal of Sexual Medicine
3264:10.1358/dot.2008.44.10.1269675
2631:10.1002/14651858.cd006533.pub2
2489:10.1002/14651858.CD007115.pub3
1415:
1231:should not be co-administered.
740:
737:
722:
252:
239:
1:
9465:Receptor/signaling modulators
8539:Tooltip Serotonin transporter
7163:Monoamine reuptake inhibitors
4545:Current Pharmaceutical Design
4413:10.1016/S0893-133X(01)00298-6
3399:BMC Musculoskeletal Disorders
3183:10.1016/s0140-6736(22)01472-6
2711:Swiatek J (13 October 2013).
2680:10.1016/S0140-6736(17)32802-7
2425:European Journal of Neurology
1830:
1391:SSRI discontinuation syndrome
1345:SSRI discontinuation syndrome
1129:On 4 November 2010, the U.S.
1104:Fibromyalgia and chronic pain
863:obsessive-compulsive disorder
248:(Other controlled substances)
8379:Tetracyclic antidepressants:
7176:Tooltip Dopamine transporter
6374:Monoamine oxidase inhibitors
5669:Anson P (12 December 2013).
5450:Food and Drug Administration
5417:Food and Drug Administration
5372:Food and Drug Administration
5308:10.1016/0024-3205(88)90579-6
4345:Food and Drug Administration
4310:Food and Drug Administration
4269:Food and Drug Administration
4230:Food and Drug Administration
4049:10.3109/13651501.2011.590209
3884:10.1097/ajp.0b013e31819be587
3872:The Clinical Journal of Pain
3783:10.1016/j.amjmed.2023.10.022
3744:Food and Drug Administration
3709:10.1097/FJC.0b013e31804d1cce
3485:Food and Drug Administration
3451:Food and Drug Administration
3322:Food and Drug Administration
3047:(85): 168–72. October 2006.
2969:Food and Drug Administration
2279:Journal of Clinical Oncology
2242:10.1212/WNL.0b013e3182166ebe
2099:International OCD Foundation
1737:Food and Drug Administration
1197:Monoamine oxidase inhibitors
1131:Food and Drug Administration
1113:Food and Drug Administration
1010:generalized anxiety disorder
1004:Generalized anxiety disorder
944:generalized anxiety disorder
891:Common side effects include
859:generalized anxiety disorder
849:, sold under the brand name
7:
8829:3,3-Diphenylcyclobutanamine
8105:3,3-Diphenylcyclobutanamine
6568:Tooltip Monoamine oxidase B
6508:Tooltip Monoamine oxidase A
6137:tetracyclic antidepressants
4835:10.1016/j.pnpbp.2007.03.004
4448:. Oxford University Press.
3008:10.1136/bmj.39213.565972.AE
2787:Annals of Internal Medicine
1798:
1741:Good Manufacturing Practice
1678:tumor necrosis factor-alpha
1143:stress urinary incontinence
1137:Stress urinary incontinence
1015:Annals of Internal Medicine
10:
9910:
9469:Monoamine releasing agents
9027:Tricyclic antidepressants:
8303:Tricyclic antidepressants:
7372:Benzatropine (benztropine)
6045:Dextromethorphan/bupropion
5638:Palmer E (11 April 2013).
5343:10.1016/j.bmcl.2003.08.079
5235:10.1186/s13018-024-04648-5
4918:10.1177/039463201002300204
4772:Lotrich FE (August 2015).
4167:10.1016/j.mehy.2009.07.011
3229:10.1007/s40263-024-01072-5
3132:10.3310/nihrevidence_57470
2891:10.1016/j.pain.2005.03.029
1708:Duloxetine was created by
1704:Cymbalta (duloxetine) 60mg
1695:
1463:aspartate aminotransferase
1349:During marketing of other
1342:
1202:Uncontrolled narrow-angle
712:Chemical and physical data
370:70% in urine, 20% in feces
18:
9613:
9537:
9457:
9413:
9282:
9093:
9022:
8821:
8745:
8559:
8532:
8410:
8374:
8298:
8097:
8021:
7935:
7849:
7822:
7505:
7359:
7323:
7247:
7196:
7169:
7065:NMDA receptor antagonists
7019:
6929:
6852:
6768:
6703:
6692:
6609:
6596:
6558:
6498:
6384:
6380:
6367:
6343:
6305:
6147:
6143:
6126:
6027:
5999:
5966:
5933:
5900:
5867:
5819:
5761:
5757:
5739:
5546:10.1136/bmj.331.7508.70-b
5184:10.1016/j.bbi.2021.06.012
4878:10.1016/j.jad.2012.08.007
4658:Clinical Pharmacokinetics
4625:"Cymbalta product insert"
4578:OnuĹŁu AH (October 2015).
4510:10.1017/s1092852900019726
4202:10.1016/j.jad.2005.09.003
4124:10.1007/s00508-014-0688-0
3593:10.1007/s11255-013-0410-6
2531:(150): 161–5. June 2014.
2336:10.1007/s00482-012-1172-2
2020:European Medicines Agency
1982:European Medicines Agency
1427:statistically significant
1059:tricyclic antidepressants
1012:(GAD). A review from the
992:Major depressive disorder
940:major depressive disorder
855:major depressive disorder
826:
801:
781:
759:
746:
716:
711:
692:
660:
632:
604:
576:
548:
520:
500:
480:
460:
435:
407:
379:
374:
364:
351:
331:
321:
311:
303:
216:
211:
186:
174:
160:
134:
104:
90:
72:
62:
57:
48:
39:
8753:Atomoxetine (tomoxetine)
8029:Atomoxetine (tomoxetine)
6751:Rubidium chloride (RbCl)
5607:Staton T (9 July 2012).
5011:10.1378/chest.117.4.1162
4557:10.2174/1381612053764805
4312:(FDA). pp. 75–140.
3364:10.3810/pgm.2012.01.2521
2292:10.1200/JCO.2013.54.0914
1793:Dr. Reddy's Laboratories
1491:Stevens–Johnson syndrome
1447:alanine aminotransferase
1339:Discontinuation syndrome
1292:(18.7%), and except for
877:. It is taken by mouth.
19:Not to be confused with
9600:Franklyn G. Prendergast
9131:mepyramine (pyrilamine)
6614:Atypical antipsychotics
5271:. USPTO. Archived from
4954:Neuropsychopharmacology
4400:Neuropsychopharmacology
4271:(FDA). pp. 11–74.
4223:Levenson M, Holland C.
3746:(FDA). 14 August 2013.
3665:"Eli Lilly and Company"
3412:10.1186/1471-2474-15-76
3041:Prescrire International
2971:(FDA). 3 September 2004
2525:Prescrire International
1911:Diário Oficial da União
1805:List of antidepressants
1731:In 2001, Lilly filed a
1487:orthostatic hypotension
1079:Prescrire International
930:million prescriptions.
9405:Vanoxerine (GBR-12909)
9252:pethidine (meperidine)
8507:pethidine (meperidine)
7295:Pethidine (meperidine)
5528:Lenzer J (July 2005).
4713:10.1055/s-2008-1073173
3085:10.1186/1471-2377-8-29
1705:
1222:Central nervous system
9595:Douglas R. Oberhelman
9560:Sir Winfried Bischoff
9531:Eli Lilly and Company
9489:Monoamine neurotoxins
9055:Dosulepin (dothiepin)
8602:Didesmethylcitalopram
8331:Dosulepin (dothiepin)
8008:Serdexmethylphenidate
7310:Serdexmethylphenidate
4383:on 12 September 2008.
3489:. 16 September 2011.
3352:Postgraduate Medicine
2846:10.4093/dmj.2023.0018
2152:"The Top 300 of 2022"
2095:"Medications for OCD"
2024:. 17 September 2018.
1986:. 17 September 2018.
1710:Eli Lilly and Company
1703:
1441:Postmarketing reports
1343:Further information:
1118:It may be useful for
1091:Combination treatment
1048:peripheral neuropathy
875:central sensitization
340:, two P450 isozymes,
9380:Methoxytetrabenazine
9345:Dihydrotetrabenazine
9159:Arylcyclohexylamines
8454:Arylcyclohexylamines
7605:Dizocilpine (MK-801)
7559:Chaenomeles speciosa
7260:Benocyclidine (BTCP)
6931:Ion channel blockers
6735:Hypericum perforatum
6603:Adjunctive therapies
5675:National Pain Report
5584:. 26 February 2007.
5421:. 24 December 1999.
4966:10.1038/npp.2011.132
4747:www.medicines.org.uk
4112:Wien Klin Wochenschr
3964:10.4088/pcc.v08n0404
2674:(10128): 1357–1366.
1733:New Drug Application
1451:alkaline phosphatase
1385:, and seizures. The
952:musculoskeletal pain
9570:Martin S. Feldstein
9004:Threohydrobupropion
8869:Desmethylsertraline
8597:Desmethylcitalopram
8280:Threohydrobupropion
8145:Desmethylsertraline
7800:Threohydrobupropion
7575:Desmethylsertraline
5751:receptor modulators
5747:reuptake inhibitors
5650:on 11 December 2013
5128:Hum Psychopharmacol
3548:10.1503/cmaj.151104
2581:10.2147/JPR.S442595
1662:Research directions
1516:
1510:Mechanism of action
1459:angioneurotic edema
272:(Prescription only)
235:(Prescription only)
36:
9550:John C. Lechleiter
9244:dextropropoxyphene
7270:Dexmethylphenidate
6795:Never to phase III
5619:on 30 October 2013
5509:on 2 February 2009
5104:10.2217/pgs.15.136
4701:Pharmacopsychiatry
4007:(4 Pt 1): 917–29.
3177:(10353): 680–690.
2368:Muscle & Nerve
1718:patent application
1706:
1674:interleukin-1 beta
1514:
1371:emotional lability
1327:Increased sweating
1306:sexual dysfunction
1300:Sexual dysfunction
1241:serotonin syndrome
1098:multiple sclerosis
924:generic medication
901:serotonin syndrome
317:~ 50% (32% to 80%)
32:
9869:CYP2D6 inhibitors
9829:
9828:
9497:
9496:
9492:
9278:
9277:
8553:
8528:
8527:
7973:Levophacetoperane
7843:
7818:
7817:
7680:Levophacetoperane
7255:4-Fluoropethidine
7190:
7129:
7128:
7037:Botulinum toxin A
7027:Alpha lipoic acid
6973:Local anesthetics
6846:pharmacotherapies
6805:
6804:
6764:
6763:
6737:(St. John's Wort)
6688:
6687:
6653:lithium carbonate
6592:
6591:
6588:
6587:
6363:
6362:
6359:
6358:
6172:Amitriptylinoxide
6122:
6121:
6118:
6117:
5681:on 2 January 2014
5275:on 7 January 2016
5222:J Orthop Surg Res
5172:Brain Behav Immun
5058:10.1002/brb3.2689
4455:978-0-19-936258-5
4377:RxList Monographs
2717:Indianapolis Star
2380:10.1002/mus.22092
2285:(18): 1941–1967.
1811:Explanatory notes
1653:therapeutic range
1600:
1599:
1431:suicidal ideation
1422:black box warning
1187:contraindications
1181:Contraindications
844:
843:
772:Interactive image
662:CompTox Dashboard
295:
280:
267:
255:
243:
230:
150:
117:
9901:
9889:Secondary amines
9846:
9845:
9844:
9837:
9605:Kathi P. Seifert
9580:Alfred G. Gilman
9565:Michael L. Eskew
9524:
9517:
9510:
9501:
9500:
9459:
9446:Antagonist-like:
9340:Deutetrabenazine
9290:
9286:
9230:MIN-117 (WF-516)
9195:Dextromethorphan
8567:6-Nitroquipazine
8557:
8556:
8551:
8547:
8542:
8540:
8536:
7963:Hydroxybupropion
7847:
7846:
7841:
7837:
7832:
7830:
7826:
7720:MIN-117 (WF-516)
7660:Hydroxybupropion
7600:Diphenylpyraline
7331:Diphenylprolinol
7194:
7193:
7188:
7184:
7179:
7177:
7173:
7156:
7149:
7142:
7133:
7132:
7120:
7117:Sodium oxybate (
7073:dextromethorphan
6994:
6990:
6913:
6909:
6887:
6883:
6868:
6864:
6839:Neuropathic pain
6832:
6825:
6818:
6809:
6808:
6745:
6711:
6694:
6693:
6667:triiodothyronine
6663:Thyroid hormones
6598:
6597:
6569:
6565:
6509:
6505:
6450:Phenoxypropazine
6382:
6381:
6369:
6368:
6313:
6309:
6155:
6151:
6145:
6144:
6128:
6127:
6007:
6003:
5974:
5970:
5941:
5937:
5908:
5904:
5875:
5871:
5827:
5823:
5769:
5765:
5759:
5758:
5741:
5740:
5721:
5714:
5707:
5698:
5697:
5691:
5690:
5688:
5686:
5677:. Archived from
5666:
5660:
5659:
5657:
5655:
5646:. Archived from
5635:
5629:
5628:
5626:
5624:
5615:. Archived from
5604:
5598:
5597:
5595:
5593:
5574:
5568:
5567:
5557:
5525:
5519:
5518:
5516:
5514:
5499:
5493:
5492:
5490:
5488:
5473:
5467:
5466:
5464:
5462:
5453:. Archived from
5441:
5435:
5434:
5432:
5430:
5407:
5401:
5395:
5394:
5390:
5388:
5386:
5380:
5369:
5361:
5355:
5354:
5326:
5320:
5319:
5291:
5285:
5284:
5282:
5280:
5264:
5258:
5257:
5247:
5237:
5213:
5204:
5203:
5166:
5160:
5159:
5140:10.1002/hup.2698
5122:
5116:
5115:
5092:Pharmacogenomics
5086:
5080:
5079:
5069:
5037:
5031:
5030:
4994:
4988:
4987:
4977:
4945:
4939:
4938:
4920:
4896:
4890:
4889:
4861:
4855:
4854:
4818:
4812:
4811:
4801:
4769:
4763:
4762:
4760:
4758:
4753:on 21 March 2020
4749:. Archived from
4739:
4733:
4732:
4696:
4690:
4689:
4653:
4647:
4646:
4644:
4642:
4636:
4629:
4621:
4610:
4609:
4599:
4575:
4569:
4568:
4539:
4530:
4529:
4493:
4487:
4486:
4481:Stahl S (2013).
4478:
4472:
4471:
4469:
4467:
4439:
4433:
4432:
4431:
4425:
4415:
4391:
4385:
4384:
4379:. Archived from
4369:
4363:
4362:
4360:
4358:
4349:. Archived from
4335:
4329:
4328:
4326:
4324:
4318:
4303:
4294:
4288:
4287:
4285:
4283:
4277:
4262:
4253:
4247:
4246:
4244:
4242:
4220:
4214:
4213:
4185:
4179:
4178:
4150:
4144:
4143:
4118:(17–18): 703–6.
4107:
4101:
4100:
4098:
4096:
4075:
4069:
4068:
4031:
4025:
4024:
3995:
3986:
3985:
3975:
3943:
3937:
3936:
3934:
3932:
3913:
3904:
3903:
3867:
3861:
3860:
3850:
3818:
3812:
3809:
3803:
3802:
3766:
3760:
3759:
3757:
3755:
3736:
3730:
3729:
3711:
3687:
3681:
3680:
3678:
3676:
3661:
3655:
3654:
3649:. Archived from
3643:
3637:
3636:
3634:
3628:. Archived from
3627:
3623:"www.uroweb.org"
3619:
3613:
3612:
3576:
3570:
3569:
3559:
3542:(5): E194–E203.
3527:
3521:
3509:
3503:
3502:
3500:
3498:
3475:
3469:
3468:
3466:
3464:
3459:on 7 August 2013
3441:
3435:
3434:
3424:
3414:
3390:
3384:
3383:
3346:
3340:
3339:
3337:
3335:
3312:
3306:
3305:
3303:
3301:
3282:
3276:
3275:
3247:
3241:
3240:
3211:
3205:
3204:
3194:
3162:
3156:
3155:
3153:
3151:
3126:. 6 April 2023.
3121:
3114:
3108:
3107:
3097:
3087:
3063:
3057:
3056:
3036:
3030:
3029:
3019:
2987:
2981:
2980:
2978:
2976:
2966:
2958:
2952:
2951:
2941:
2917:
2911:
2910:
2874:
2868:
2867:
2857:
2834:Diabetes Metab J
2825:
2819:
2818:
2782:
2776:
2775:
2739:
2733:
2732:
2730:
2728:
2708:
2702:
2701:
2691:
2659:
2653:
2652:
2642:
2610:
2604:
2603:
2593:
2583:
2559:
2553:
2552:
2550:
2548:
2517:
2511:
2510:
2500:
2468:
2459:
2458:
2440:
2416:
2410:
2409:
2391:
2362:
2356:
2355:
2319:
2313:
2312:
2294:
2270:
2264:
2263:
2253:
2221:
2215:
2203:
2197:
2196:
2194:
2192:
2178:
2172:
2171:
2169:
2167:
2148:
2142:
2141:
2124:
2115:
2114:
2112:
2110:
2091:
2085:
2084:
2082:
2080:
2061:
2038:
2037:
2035:
2033:
2011:
2000:
1999:
1997:
1995:
1973:
1962:
1961:
1959:
1957:
1938:
1927:
1926:
1924:
1922:
1903:
1897:
1896:
1894:
1892:
1882:nctr-crs.fda.gov
1874:
1868:
1867:
1865:
1863:
1844:
1824:
1821:
1788:in added sales.
1787:
1782:
1778:
1622:Pharmacokinetics
1612:serotonin uptake
1517:
1515:Binding profile
1513:
1172:discontinuation.
1042:Neuropathic pain
948:neuropathic pain
929:
880:Duloxetine is a
871:neuropathic pain
840:
839:
832:
774:
754:
742:
739:
736:
730:
724:
707:
696:
685:
684:
670:
668:
652:
646:
625:
617:
597:
589:
569:
561:
541:
533:
513:
493:
473:
453:
443:
442:
428:
420:
356:
293:
290:
285:
278:
275:
265:
262:
254:
251:
241:
238:
228:
225:
203:
148:
145:
127:
116:
113:
100:
86:
53:
44:
37:
35:
31:
9909:
9908:
9904:
9903:
9902:
9900:
9899:
9898:
9894:Antidepressants
9884:Naphthol ethers
9854:
9853:
9852:
9842:
9840:
9832:
9830:
9825:
9609:
9590:Ellen R. Marram
9575:J. Erik Fyrwald
9533:
9528:
9498:
9493:
9453:
9431:DAT modulators:
9409:
9310:methamphetamine
9288:
9274:
9185:Cyclobenzaprine
9127:diphenhydramine
9115:brompheniramine
9089:
9018:
8817:
8783:Levomilnacipran
8741:
8549:
8541:
8538:
8524:
8422:brompheniramine
8406:
8370:
8294:
8093:
8054:Levomilnacipran
8017:
7988:Methylphenidate
7931:
7839:
7831:
7828:
7814:
7501:
7355:
7319:
7290:Methylphenidate
7265:Desoxypipradrol
7243:
7186:
7178:
7175:
7165:
7160:
7130:
7125:
7015:
6992:
6939:Anticonvulsants
6925:
6911:
6885:
6866:
6848:
6836:
6806:
6801:
6800:
6785:Clinical trials
6760:
6699:
6684:
6680:
6672:
6657:lithium citrate
6605:
6584:
6567:
6564:
6554:
6507:
6504:
6494:
6470:Tranylcypromine
6376:
6355:
6339:
6311:
6301:
6153:
6139:
6114:
6023:
6005:
5995:
5972:
5962:
5939:
5929:
5906:
5896:
5873:
5863:
5844:Levomilnacipran
5825:
5815:
5767:
5753:
5735:
5728:Antidepressants
5725:
5695:
5694:
5684:
5682:
5667:
5663:
5653:
5651:
5636:
5632:
5622:
5620:
5605:
5601:
5591:
5589:
5576:
5575:
5571:
5526:
5522:
5512:
5510:
5501:
5500:
5496:
5486:
5484:
5483:on 1 March 2015
5475:
5474:
5470:
5460:
5458:
5443:
5442:
5438:
5428:
5426:
5409:
5408:
5404:
5392:
5384:
5382:
5378:
5370:(Report). U.S.
5367:
5363:
5362:
5358:
5337:(24): 4477–80.
5327:
5323:
5302:(24): 2049–57.
5292:
5288:
5278:
5276:
5265:
5261:
5214:
5207:
5167:
5163:
5123:
5119:
5098:(17): 1919–29.
5087:
5083:
5038:
5034:
4995:
4991:
4960:(12): 2452–59.
4946:
4942:
4897:
4893:
4866:J Affect Disord
4862:
4858:
4819:
4815:
4770:
4766:
4756:
4754:
4741:
4740:
4736:
4697:
4693:
4654:
4650:
4640:
4638:
4634:
4627:
4623:
4622:
4613:
4576:
4572:
4551:(12): 1475–93.
4540:
4533:
4494:
4490:
4479:
4475:
4465:
4463:
4456:
4440:
4436:
4426:
4392:
4388:
4371:
4370:
4366:
4356:
4354:
4353:on 22 July 2017
4337:
4336:
4332:
4322:
4320:
4316:
4301:
4295:
4291:
4281:
4279:
4275:
4260:
4254:
4250:
4240:
4238:
4221:
4217:
4196:(1–3): 207–12.
4186:
4182:
4151:
4147:
4108:
4104:
4094:
4092:
4077:
4076:
4072:
4032:
4028:
3996:
3989:
3944:
3940:
3930:
3928:
3915:
3914:
3907:
3868:
3864:
3819:
3815:
3810:
3806:
3767:
3763:
3753:
3751:
3738:
3737:
3733:
3688:
3684:
3674:
3672:
3663:
3662:
3658:
3645:
3644:
3640:
3632:
3625:
3621:
3620:
3616:
3577:
3573:
3528:
3524:
3520:. London, 2006.
3510:
3506:
3496:
3494:
3477:
3476:
3472:
3462:
3460:
3443:
3442:
3438:
3391:
3387:
3347:
3343:
3333:
3331:
3314:
3313:
3309:
3299:
3297:
3296:on 30 July 2008
3284:
3283:
3279:
3248:
3244:
3212:
3208:
3163:
3159:
3149:
3147:
3116:
3115:
3111:
3064:
3060:
3038:
3037:
3033:
2988:
2984:
2974:
2972:
2964:
2960:
2959:
2955:
2918:
2914:
2885:(1–2): 109–18.
2875:
2871:
2826:
2822:
2783:
2779:
2740:
2736:
2726:
2724:
2709:
2705:
2660:
2656:
2611:
2607:
2560:
2556:
2546:
2544:
2519:
2518:
2514:
2483:(1): CD007115.
2469:
2462:
2431:(9): 1113–e88.
2417:
2413:
2363:
2359:
2320:
2316:
2271:
2267:
2236:(20): 1758–65.
2222:
2218:
2214:. London, 2010.
2204:
2200:
2190:
2188:
2180:
2179:
2175:
2165:
2163:
2150:
2149:
2145:
2138:
2126:
2125:
2118:
2108:
2106:
2093:
2092:
2088:
2078:
2076:
2063:
2062:
2041:
2031:
2029:
2015:"Yentreve EPAR"
2013:
2012:
2003:
1993:
1991:
1977:"Cymbalta EPAR"
1975:
1974:
1965:
1955:
1953:
1940:
1939:
1930:
1920:
1918:
1905:
1904:
1900:
1890:
1888:
1876:
1875:
1871:
1861:
1859:
1846:
1845:
1838:
1833:
1828:
1827:
1822:
1818:
1813:
1801:
1786:US$ 1.5 billion
1785:
1780:
1776:
1698:
1664:
1632:
1624:
1592:
1579:
1566:
1526:
1512:
1507:
1443:
1418:
1347:
1341:
1329:
1302:
1252:
1250:Adverse effects
1227:Duloxetine and
1208:clinical trials
1183:
1139:
1106:
1071:anticonvulsants
1069:), traditional
1044:
1006:
994:
975:
936:
927:
835:
833:
830:(what is this?)
827:
822:
819:
814:
809:
808:
797:
794:
789:
788:
777:
752:
733:
727:
688:
664:
656:
628:
600:
572:
544:
516:
496:
476:
456:
439:
431:
403:
400:
387:
386:
354:
323:Protein binding
313:Bioavailability
305:Pharmacokinetic
299:
283:
207:
163:
156:
137:
130:
28:
17:
12:
11:
5:
9907:
9897:
9896:
9891:
9886:
9881:
9876:
9871:
9866:
9851:
9850:
9827:
9826:
9824:
9823:
9818:
9813:
9808:
9803:
9798:
9793:
9788:
9783:
9778:
9773:
9768:
9763:
9758:
9753:
9748:
9743:
9738:
9733:
9728:
9723:
9718:
9713:
9708:
9703:
9698:
9693:
9688:
9683:
9678:
9673:
9668:
9663:
9658:
9653:
9648:
9643:
9638:
9633:
9628:
9623:
9617:
9615:
9611:
9610:
9608:
9607:
9602:
9597:
9592:
9587:
9582:
9577:
9572:
9567:
9562:
9557:
9552:
9546:
9544:
9535:
9534:
9527:
9526:
9519:
9512:
9504:
9495:
9494:
9458:
9455:
9454:
9452:
9451:
9439:
9427:
9426:
9421:DAT enhancers:
9417:
9415:
9411:
9410:
9408:
9407:
9402:
9397:
9392:
9387:
9382:
9377:
9372:
9367:
9362:
9357:
9352:
9347:
9342:
9337:
9332:
9327:
9322:
9317:
9299:
9293:
9291:
9280:
9279:
9276:
9275:
9273:
9272:
9267:
9237:
9232:
9227:
9222:
9217:
9212:
9207:
9202:
9197:
9192:
9187:
9182:
9156:
9145:Antipsychotics
9142:
9139:tripelennamine
9123:dimenhydrinate
9119:chlorphenamine
9111:Antihistamines
9108:
9103:
9094:
9091:
9090:
9088:
9087:
9082:
9077:
9072:
9067:
9062:
9057:
9052:
9047:
9045:Cyanodothiepin
9042:
9037:
9032:
9023:
9020:
9019:
9017:
9016:
9006:
9001:
8996:
8991:
8986:
8981:
8976:
8971:
8966:
8961:
8956:
8951:
8946:
8941:
8936:
8931:
8926:
8921:
8916:
8911:
8906:
8901:
8896:
8891:
8886:
8881:
8876:
8871:
8866:
8861:
8856:
8851:
8846:
8841:
8836:
8831:
8822:
8819:
8818:
8816:
8815:
8810:
8805:
8800:
8795:
8790:
8785:
8780:
8775:
8770:
8768:Desvenlafaxine
8765:
8760:
8755:
8746:
8743:
8742:
8740:
8739:
8734:
8729:
8724:
8719:
8714:
8709:
8704:
8699:
8694:
8685:
8684:
8679:
8674:
8669:
8664:
8659:
8654:
8649:
8644:
8639:
8634:
8629:
8624:
8619:
8614:
8609:
8604:
8599:
8594:
8589:
8584:
8579:
8574:
8569:
8560:
8554:
8530:
8529:
8526:
8525:
8523:
8522:
8492:
8487:
8482:
8475:
8470:
8465:
8451:
8440:Antipsychotics
8437:
8434:tripelennamine
8426:chlorphenamine
8418:Antihistamines
8411:
8408:
8407:
8405:
8404:
8399:
8394:
8389:
8384:
8375:
8372:
8371:
8369:
8368:
8363:
8358:
8353:
8348:
8343:
8338:
8333:
8328:
8323:
8318:
8313:
8308:
8299:
8296:
8295:
8293:
8292:
8282:
8277:
8272:
8267:
8262:
8257:
8252:
8247:
8242:
8237:
8232:
8227:
8222:
8217:
8212:
8207:
8202:
8197:
8192:
8187:
8182:
8177:
8172:
8167:
8162:
8157:
8152:
8147:
8142:
8137:
8132:
8127:
8122:
8117:
8112:
8107:
8098:
8095:
8094:
8092:
8091:
8086:
8081:
8076:
8071:
8066:
8061:
8056:
8051:
8046:
8041:
8039:Desvenlafaxine
8036:
8031:
8022:
8019:
8018:
8016:
8015:
8010:
8005:
8000:
7995:
7990:
7985:
7980:
7975:
7970:
7965:
7960:
7955:
7950:
7945:
7936:
7933:
7932:
7930:
7929:
7924:
7919:
7914:
7909:
7904:
7899:
7894:
7889:
7884:
7879:
7874:
7869:
7864:
7859:
7850:
7844:
7820:
7819:
7816:
7815:
7813:
7812:
7807:
7805:Tripelennamine
7802:
7797:
7792:
7787:
7782:
7777:
7772:
7767:
7762:
7757:
7752:
7747:
7742:
7737:
7732:
7727:
7722:
7717:
7712:
7707:
7702:
7697:
7692:
7687:
7682:
7677:
7672:
7667:
7662:
7657:
7652:
7647:
7642:
7637:
7632:
7627:
7622:
7617:
7612:
7607:
7602:
7597:
7592:
7587:
7582:
7577:
7572:
7567:
7562:
7555:
7550:
7545:
7540:
7535:
7530:
7528:Amfonelic acid
7525:
7520:
7515:
7506:
7503:
7502:
7500:
7499:
7494:
7489:
7484:
7479:
7474:
7469:
7464:
7459:
7454:
7449:
7444:
7439:
7434:
7429:
7424:
7419:
7414:
7409:
7404:
7399:
7394:
7389:
7384:
7379:
7374:
7369:
7360:
7357:
7356:
7354:
7353:
7348:
7343:
7338:
7333:
7324:
7321:
7320:
7318:
7317:
7312:
7307:
7302:
7297:
7292:
7287:
7282:
7280:Ethylphenidate
7277:
7272:
7267:
7262:
7257:
7248:
7245:
7244:
7242:
7241:
7236:
7231:
7226:
7221:
7216:
7211:
7206:
7197:
7191:
7167:
7166:
7159:
7158:
7151:
7144:
7136:
7127:
7126:
7124:
7123:
7114:
7080:
7062:
7044:
7039:
7034:
7029:
7023:
7021:
7017:
7016:
7014:
7013:
7008:
6985:
6980:
6970:
6935:
6933:
6927:
6926:
6924:
6923:
6901:
6878:
6858:
6856:
6854:Monoaminergics
6850:
6849:
6835:
6834:
6827:
6820:
6812:
6803:
6802:
6799:
6798:
6797:
6796:
6793:
6782:
6776:
6770:
6769:
6766:
6765:
6762:
6761:
6759:
6758:
6753:
6748:
6739:
6731:
6714:
6708:Ademetionine (
6704:
6701:
6700:
6690:
6689:
6686:
6685:
6683:
6682:
6678:
6670:
6660:
6646:
6641:
6610:
6607:
6606:
6594:
6593:
6590:
6589:
6586:
6585:
6583:
6582:
6573:
6571:
6562:
6556:
6555:
6553:
6552:
6547:
6542:
6537:
6532:
6527:
6522:
6513:
6511:
6502:
6496:
6495:
6493:
6492:
6483:
6482:
6473:
6472:
6467:
6462:
6457:
6452:
6447:
6442:
6437:
6432:
6427:
6422:
6417:
6412:
6407:
6402:
6397:
6388:
6386:
6378:
6377:
6365:
6364:
6361:
6360:
6357:
6356:
6354:
6353:
6347:
6345:
6341:
6340:
6338:
6337:
6332:
6327:
6322:
6316:
6314:
6303:
6302:
6300:
6299:
6294:
6289:
6284:
6279:
6274:
6269:
6264:
6259:
6254:
6249:
6244:
6239:
6234:
6229:
6227:Imipraminoxide
6224:
6219:
6214:
6209:
6204:
6199:
6194:
6189:
6184:
6179:
6174:
6169:
6164:
6158:
6156:
6141:
6140:
6124:
6123:
6120:
6119:
6116:
6115:
6113:
6112:
6107:
6102:
6097:
6092:
6087:
6082:
6077:
6072:
6067:
6062:
6057:
6052:
6047:
6042:
6037:
6031:
6029:
6025:
6024:
6022:
6021:
6016:
6010:
6008:
5997:
5996:
5994:
5993:
5988:
5983:
5977:
5975:
5964:
5963:
5961:
5960:
5955:
5950:
5944:
5942:
5931:
5930:
5928:
5927:
5922:
5917:
5911:
5909:
5898:
5897:
5895:
5894:
5889:
5884:
5878:
5876:
5865:
5864:
5862:
5861:
5856:
5851:
5846:
5841:
5836:
5834:Desvenlafaxine
5830:
5828:
5817:
5816:
5814:
5813:
5808:
5803:
5798:
5793:
5788:
5783:
5778:
5772:
5770:
5755:
5754:
5737:
5736:
5724:
5723:
5716:
5709:
5701:
5693:
5692:
5661:
5630:
5599:
5569:
5520:
5494:
5468:
5457:on 13 May 2009
5436:
5402:
5356:
5321:
5286:
5259:
5205:
5161:
5117:
5081:
5032:
5005:(4): 1162–72.
4989:
4940:
4891:
4856:
4829:(5): 1044–53.
4813:
4764:
4734:
4707:(4): 151–155.
4691:
4664:(5): 281–294.
4648:
4611:
4590:(2): 123–128.
4570:
4531:
4488:
4473:
4454:
4442:Li JJ (2015).
4434:
4386:
4364:
4330:
4289:
4248:
4215:
4180:
4155:Med Hypotheses
4145:
4102:
4070:
4026:
3987:
3938:
3905:
3862:
3813:
3804:
3761:
3731:
3702:(6): 384–393.
3682:
3656:
3653:on 4 May 2014.
3638:
3635:on 4 May 2014.
3614:
3571:
3522:
3504:
3470:
3436:
3385:
3341:
3307:
3277:
3258:(10): 725–34.
3252:Drugs of Today
3242:
3223:(3): 205–224.
3206:
3157:
3109:
3058:
3031:
2982:
2953:
2912:
2869:
2840:(6): 743–756.
2820:
2777:
2734:
2703:
2654:
2605:
2554:
2512:
2460:
2411:
2357:
2330:(3): 297–310.
2314:
2265:
2216:
2198:
2173:
2143:
2136:
2116:
2086:
2039:
2001:
1963:
1928:
1898:
1869:
1835:
1834:
1832:
1829:
1826:
1825:
1815:
1814:
1812:
1809:
1808:
1807:
1800:
1797:
1779:in 2012, with
1758:liver toxicity
1750:blood pressure
1697:
1694:
1686:interleukin 10
1663:
1660:
1630:
1623:
1620:
1616:norepinephrine
1598:
1597:
1594:
1590:
1585:
1584:
1581:
1577:
1572:
1571:
1568:
1564:
1559:
1558:
1555:
1549:
1548:
1545:
1539:
1538:
1535:
1529:
1528:
1524:
1521:
1511:
1508:
1506:
1503:
1475:hepatotoxicity
1442:
1439:
1417:
1414:
1359:dysphoric mood
1340:
1337:
1328:
1325:
1301:
1298:
1251:
1248:
1233:
1232:
1225:
1219:
1200:
1194:
1185:The following
1182:
1179:
1178:
1177:
1173:
1165:
1157:
1138:
1135:
1124:osteoarthritis
1105:
1102:
1043:
1040:
1005:
1002:
993:
990:
974:
971:
935:
932:
909:liver problems
842:
841:
824:
823:
821:
820:
817:
815:
812:
804:
803:
802:
799:
798:
796:
795:
792:
784:
783:
782:
779:
778:
776:
775:
767:
765:
757:
756:
750:
744:
743:
731:
725:
720:
714:
713:
709:
708:
698:
690:
689:
687:
686:
673:
671:
658:
657:
655:
654:
638:
636:
630:
629:
627:
626:
618:
610:
608:
602:
601:
599:
598:
590:
582:
580:
574:
573:
571:
570:
562:
554:
552:
546:
545:
543:
542:
534:
526:
524:
518:
517:
515:
514:
506:
504:
498:
497:
495:
494:
486:
484:
478:
477:
475:
474:
466:
464:
458:
457:
455:
454:
446:
444:
433:
432:
430:
429:
421:
413:
411:
405:
404:
402:
401:
390:
382:
381:
380:
377:
376:
372:
371:
368:
362:
361:
358:
349:
348:
335:
329:
328:
325:
319:
318:
315:
309:
308:
301:
300:
298:
297:
288:
273:
260:
249:
236:
222:
220:
214:
213:
209:
208:
206:
205:
192:
190:
184:
183:
178:
172:
171:
166:
164:administration
158:
157:
155:
154:
152:
142:
140:
132:
131:
129:
128:
110:
108:
102:
101:
94:
88:
87:
80:
70:
69:
66:
60:
59:
55:
54:
46:
45:
15:
9:
6:
4:
3:
2:
9906:
9895:
9892:
9890:
9887:
9885:
9882:
9880:
9877:
9875:
9872:
9870:
9867:
9865:
9862:
9861:
9859:
9849:
9839:
9838:
9835:
9822:
9819:
9817:
9814:
9812:
9809:
9807:
9804:
9802:
9799:
9797:
9794:
9792:
9789:
9787:
9784:
9782:
9779:
9777:
9774:
9772:
9769:
9767:
9764:
9762:
9759:
9757:
9754:
9752:
9749:
9747:
9744:
9742:
9739:
9737:
9734:
9732:
9729:
9727:
9724:
9722:
9719:
9717:
9714:
9712:
9709:
9707:
9704:
9702:
9699:
9697:
9694:
9692:
9689:
9687:
9684:
9682:
9679:
9677:
9674:
9672:
9669:
9667:
9664:
9662:
9659:
9657:
9654:
9652:
9649:
9647:
9644:
9642:
9639:
9637:
9634:
9632:
9629:
9627:
9624:
9622:
9619:
9618:
9616:
9612:
9606:
9603:
9601:
9598:
9596:
9593:
9591:
9588:
9586:
9585:Karen N. Horn
9583:
9581:
9578:
9576:
9573:
9571:
9568:
9566:
9563:
9561:
9558:
9556:
9555:Ralph Alvarez
9553:
9551:
9548:
9547:
9545:
9543:
9540:
9536:
9532:
9525:
9520:
9518:
9513:
9511:
9506:
9505:
9502:
9491:
9490:
9486:
9482:
9481:Serotonergics
9478:
9477:Dopaminergics
9474:
9470:
9466:
9463:
9456:
9450:
9447:
9443:
9440:
9438:
9435:
9434:Agonist-like:
9432:
9429:
9428:
9425:
9422:
9419:
9418:
9416:
9412:
9406:
9403:
9401:
9398:
9396:
9395:Tetrabenazine
9393:
9391:
9388:
9386:
9383:
9381:
9378:
9376:
9373:
9371:
9368:
9366:
9363:
9361:
9358:
9356:
9353:
9351:
9348:
9346:
9343:
9341:
9338:
9336:
9333:
9331:
9328:
9326:
9323:
9321:
9318:
9315:
9311:
9307:
9303:
9300:
9298:
9295:
9294:
9292:
9287:
9281:
9271:
9268:
9265:
9261:
9257:
9253:
9249:
9245:
9241:
9238:
9236:
9233:
9231:
9228:
9226:
9223:
9221:
9218:
9216:
9213:
9211:
9208:
9206:
9203:
9201:
9198:
9196:
9193:
9191:
9188:
9186:
9183:
9180:
9179:phencyclidine
9176:
9175:methoxetamine
9172:
9168:
9164:
9160:
9157:
9154:
9150:
9146:
9143:
9140:
9136:
9132:
9128:
9124:
9120:
9116:
9112:
9109:
9107:
9104:
9102:
9099:
9096:
9095:
9092:
9086:
9085:Protriptyline
9083:
9081:
9078:
9076:
9075:Nortriptyline
9073:
9071:
9068:
9066:
9063:
9061:
9058:
9056:
9053:
9051:
9048:
9046:
9043:
9041:
9038:
9036:
9033:
9031:
9030:Amitriptyline
9028:
9025:
9024:
9021:
9014:
9010:
9007:
9005:
9002:
9000:
8997:
8995:
8994:Tedatioxetine
8992:
8990:
8987:
8985:
8982:
8980:
8977:
8975:
8972:
8970:
8967:
8965:
8962:
8960:
8957:
8955:
8952:
8950:
8947:
8945:
8942:
8940:
8937:
8935:
8932:
8930:
8927:
8925:
8922:
8920:
8917:
8915:
8912:
8910:
8907:
8905:
8902:
8900:
8897:
8895:
8892:
8890:
8887:
8885:
8882:
8880:
8877:
8875:
8872:
8870:
8867:
8865:
8862:
8860:
8857:
8855:
8854:Centanafadine
8852:
8850:
8847:
8845:
8842:
8840:
8837:
8835:
8832:
8830:
8827:
8824:
8823:
8820:
8814:
8811:
8809:
8806:
8804:
8801:
8799:
8798:N-Methyl-PPPA
8796:
8794:
8791:
8789:
8786:
8784:
8781:
8779:
8776:
8774:
8771:
8769:
8766:
8764:
8761:
8759:
8756:
8754:
8751:
8748:
8747:
8744:
8738:
8735:
8733:
8730:
8728:
8725:
8723:
8720:
8718:
8715:
8713:
8710:
8708:
8705:
8703:
8700:
8698:
8695:
8693:
8690:
8687:
8686:
8683:
8680:
8678:
8675:
8673:
8670:
8668:
8665:
8663:
8660:
8658:
8655:
8653:
8650:
8648:
8645:
8643:
8640:
8638:
8637:Norfluoxetine
8635:
8633:
8630:
8628:
8625:
8623:
8620:
8618:
8615:
8613:
8610:
8608:
8605:
8603:
8600:
8598:
8595:
8593:
8590:
8588:
8585:
8583:
8580:
8578:
8577:Centpropazine
8575:
8573:
8570:
8568:
8565:
8562:
8561:
8558:
8555:
8548:
8537:
8531:
8520:
8516:
8512:
8508:
8504:
8500:
8499:desmetramadol
8496:
8493:
8491:
8488:
8486:
8483:
8481:
8480:
8479:Ginkgo biloba
8476:
8474:
8471:
8469:
8466:
8463:
8462:phencyclidine
8459:
8455:
8452:
8449:
8445:
8441:
8438:
8435:
8431:
8427:
8423:
8419:
8416:
8413:
8412:
8409:
8403:
8400:
8398:
8395:
8393:
8390:
8388:
8385:
8383:
8380:
8377:
8376:
8373:
8367:
8364:
8362:
8361:Protriptyline
8359:
8357:
8356:Nortriptyline
8354:
8352:
8349:
8347:
8344:
8342:
8339:
8337:
8334:
8332:
8329:
8327:
8324:
8322:
8319:
8317:
8314:
8312:
8309:
8307:
8306:Amitriptyline
8304:
8301:
8300:
8297:
8290:
8286:
8283:
8281:
8278:
8276:
8273:
8271:
8270:Tedatioxetine
8268:
8266:
8263:
8261:
8258:
8256:
8253:
8251:
8248:
8246:
8243:
8241:
8238:
8236:
8233:
8231:
8228:
8226:
8223:
8221:
8218:
8216:
8213:
8211:
8208:
8206:
8203:
8201:
8198:
8196:
8193:
8191:
8188:
8186:
8183:
8181:
8178:
8176:
8173:
8171:
8168:
8166:
8163:
8161:
8158:
8156:
8153:
8151:
8148:
8146:
8143:
8141:
8138:
8136:
8133:
8131:
8130:Centanafadine
8128:
8126:
8123:
8121:
8118:
8116:
8113:
8111:
8108:
8106:
8103:
8100:
8099:
8096:
8090:
8087:
8085:
8082:
8080:
8077:
8075:
8072:
8070:
8069:N-Methyl-PPPA
8067:
8065:
8062:
8060:
8057:
8055:
8052:
8050:
8047:
8045:
8042:
8040:
8037:
8035:
8032:
8030:
8027:
8024:
8023:
8020:
8014:
8011:
8009:
8006:
8004:
8001:
7999:
7996:
7994:
7991:
7989:
7986:
7984:
7981:
7979:
7976:
7974:
7971:
7969:
7966:
7964:
7961:
7959:
7956:
7954:
7951:
7949:
7946:
7944:
7941:
7938:
7937:
7934:
7928:
7925:
7923:
7920:
7918:
7915:
7913:
7910:
7908:
7905:
7903:
7900:
7898:
7895:
7893:
7890:
7888:
7885:
7883:
7880:
7878:
7875:
7873:
7870:
7868:
7865:
7863:
7860:
7858:
7855:
7852:
7851:
7848:
7845:
7838:
7827:
7821:
7811:
7808:
7806:
7803:
7801:
7798:
7796:
7795:Tedatioxetine
7793:
7791:
7788:
7786:
7783:
7781:
7778:
7776:
7773:
7771:
7768:
7766:
7763:
7761:
7758:
7756:
7753:
7751:
7748:
7746:
7743:
7741:
7738:
7736:
7733:
7731:
7728:
7726:
7723:
7721:
7718:
7716:
7713:
7711:
7708:
7706:
7703:
7701:
7698:
7696:
7693:
7691:
7688:
7686:
7683:
7681:
7678:
7676:
7673:
7671:
7668:
7666:
7663:
7661:
7658:
7656:
7653:
7651:
7648:
7646:
7643:
7641:
7638:
7636:
7633:
7631:
7628:
7626:
7623:
7621:
7618:
7616:
7613:
7611:
7608:
7606:
7603:
7601:
7598:
7596:
7593:
7591:
7588:
7586:
7583:
7581:
7578:
7576:
7573:
7571:
7568:
7566:
7563:
7561:
7560:
7556:
7554:
7551:
7549:
7546:
7544:
7541:
7539:
7536:
7534:
7531:
7529:
7526:
7524:
7521:
7519:
7516:
7514:
7511:
7508:
7507:
7504:
7498:
7495:
7493:
7490:
7488:
7485:
7483:
7480:
7478:
7475:
7473:
7470:
7468:
7465:
7463:
7460:
7458:
7455:
7453:
7450:
7448:
7445:
7443:
7440:
7438:
7435:
7433:
7430:
7428:
7425:
7423:
7420:
7418:
7417:Ioflupane (I)
7415:
7413:
7410:
7408:
7405:
7403:
7400:
7398:
7395:
7393:
7390:
7388:
7385:
7383:
7380:
7378:
7375:
7373:
7370:
7368:
7365:
7362:
7361:
7358:
7352:
7349:
7347:
7344:
7342:
7339:
7337:
7334:
7332:
7329:
7328:Pyrrolidines:
7326:
7325:
7322:
7316:
7315:Tenocyclidine
7313:
7311:
7308:
7306:
7303:
7301:
7300:Phencyclidine
7298:
7296:
7293:
7291:
7288:
7286:
7283:
7281:
7278:
7276:
7273:
7271:
7268:
7266:
7263:
7261:
7258:
7256:
7253:
7250:
7249:
7246:
7240:
7237:
7235:
7232:
7230:
7227:
7225:
7222:
7220:
7217:
7215:
7212:
7210:
7207:
7205:
7202:
7199:
7198:
7195:
7192:
7185:
7174:
7168:
7164:
7157:
7152:
7150:
7145:
7143:
7138:
7137:
7134:
7122:
7115:
7112:
7108:
7104:
7103:buprenorphine
7100:
7096:
7092:
7088:
7084:
7081:
7078:
7074:
7070:
7066:
7063:
7060:
7056:
7052:
7048:
7045:
7043:
7040:
7038:
7035:
7033:
7030:
7028:
7025:
7024:
7022:
7018:
7012:
7009:
7006:
7002:
7001:nortriptyline
6998:
6997:amitriptyline
6991:
6986:
6984:
6981:
6978:
6974:
6971:
6968:
6964:
6960:
6959:oxcarbazepine
6956:
6955:carbamazepine
6952:
6948:
6944:
6940:
6937:
6936:
6934:
6932:
6928:
6921:
6917:
6910:
6905:
6902:
6899:
6895:
6894:nortriptyline
6891:
6890:amitriptyline
6884:
6879:
6876:
6872:
6865:
6860:
6859:
6857:
6855:
6851:
6847:
6844:
6840:
6833:
6828:
6826:
6821:
6819:
6814:
6813:
6810:
6794:
6792:
6789:
6788:
6786:
6783:
6780:
6777:
6775:
6772:
6771:
6767:
6757:
6754:
6752:
6749:
6747:
6740:
6738:
6736:
6732:
6729:
6725:
6721:
6720:neurosteroids
6718:
6715:
6713:
6706:
6705:
6702:
6698:Miscellaneous
6695:
6691:
6676:
6675:levothyroxine
6668:
6664:
6661:
6658:
6654:
6650:
6647:
6645:
6642:
6639:
6635:
6631:
6627:
6623:
6622:brexpiprazole
6619:
6615:
6612:
6611:
6608:
6604:
6599:
6595:
6581:
6578:
6577:Irreversible:
6575:
6574:
6572:
6566:
6557:
6551:
6548:
6546:
6543:
6541:
6538:
6536:
6533:
6531:
6528:
6526:
6523:
6521:
6518:
6515:
6514:
6512:
6506:
6497:
6491:
6488:
6485:
6484:
6481:
6478:
6475:
6474:
6471:
6468:
6466:
6463:
6461:
6458:
6456:
6453:
6451:
6448:
6446:
6443:
6441:
6438:
6436:
6433:
6431:
6428:
6426:
6423:
6421:
6418:
6416:
6413:
6411:
6410:Isocarboxazid
6408:
6406:
6403:
6401:
6398:
6396:
6393:
6392:Irreversible:
6390:
6389:
6387:
6385:Non-selective
6383:
6379:
6375:
6370:
6366:
6352:
6349:
6348:
6346:
6342:
6336:
6333:
6331:
6328:
6326:
6323:
6321:
6318:
6317:
6315:
6310:
6304:
6298:
6295:
6293:
6290:
6288:
6285:
6283:
6282:Protriptyline
6280:
6278:
6275:
6273:
6270:
6268:
6265:
6263:
6260:
6258:
6257:Nortriptyline
6255:
6253:
6252:Nitroxazepine
6250:
6248:
6245:
6243:
6240:
6238:
6235:
6233:
6230:
6228:
6225:
6223:
6220:
6218:
6215:
6213:
6210:
6208:
6205:
6203:
6200:
6198:
6195:
6193:
6192:Demexiptiline
6190:
6188:
6185:
6183:
6180:
6178:
6175:
6173:
6170:
6168:
6167:Amitriptyline
6165:
6163:
6160:
6159:
6157:
6152:
6146:
6142:
6138:
6134:
6129:
6125:
6111:
6108:
6106:
6103:
6101:
6098:
6096:
6093:
6091:
6088:
6086:
6083:
6081:
6078:
6076:
6073:
6071:
6068:
6066:
6063:
6061:
6058:
6056:
6053:
6051:
6048:
6046:
6043:
6041:
6038:
6036:
6033:
6032:
6030:
6026:
6020:
6017:
6015:
6012:
6011:
6009:
6004:
5998:
5992:
5989:
5987:
5984:
5982:
5979:
5978:
5976:
5971:
5965:
5959:
5956:
5954:
5951:
5949:
5946:
5945:
5943:
5938:
5932:
5926:
5923:
5921:
5918:
5916:
5913:
5912:
5910:
5905:
5899:
5893:
5890:
5888:
5885:
5883:
5880:
5879:
5877:
5872:
5866:
5860:
5857:
5855:
5852:
5850:
5847:
5845:
5842:
5840:
5837:
5835:
5832:
5831:
5829:
5824:
5818:
5812:
5809:
5807:
5804:
5802:
5799:
5797:
5794:
5792:
5789:
5787:
5784:
5782:
5779:
5777:
5774:
5773:
5771:
5766:
5760:
5756:
5752:
5748:
5742:
5738:
5733:
5729:
5722:
5717:
5715:
5710:
5708:
5703:
5702:
5699:
5680:
5676:
5672:
5665:
5649:
5645:
5641:
5634:
5618:
5614:
5610:
5603:
5587:
5583:
5579:
5573:
5565:
5561:
5556:
5551:
5547:
5543:
5539:
5535:
5531:
5524:
5508:
5504:
5498:
5482:
5478:
5472:
5456:
5452:
5451:
5446:
5440:
5424:
5420:
5418:
5412:
5406:
5399:
5398:public domain
5377:
5374:(FDA). 2003.
5373:
5366:
5360:
5352:
5348:
5344:
5340:
5336:
5332:
5325:
5317:
5313:
5309:
5305:
5301:
5297:
5296:Life Sciences
5290:
5274:
5270:
5263:
5255:
5251:
5246:
5241:
5236:
5231:
5227:
5223:
5219:
5212:
5210:
5201:
5197:
5193:
5189:
5185:
5181:
5177:
5173:
5165:
5157:
5153:
5149:
5145:
5141:
5137:
5133:
5129:
5121:
5113:
5109:
5105:
5101:
5097:
5093:
5085:
5077:
5073:
5068:
5063:
5059:
5055:
5051:
5047:
5043:
5036:
5028:
5024:
5020:
5016:
5012:
5008:
5004:
5000:
4993:
4985:
4981:
4976:
4971:
4967:
4963:
4959:
4955:
4951:
4944:
4936:
4932:
4928:
4924:
4919:
4914:
4911:(2): 417–22.
4910:
4906:
4902:
4895:
4887:
4883:
4879:
4875:
4871:
4867:
4860:
4852:
4848:
4844:
4840:
4836:
4832:
4828:
4824:
4817:
4809:
4805:
4800:
4795:
4791:
4787:
4783:
4779:
4775:
4768:
4752:
4748:
4744:
4738:
4730:
4726:
4722:
4718:
4714:
4710:
4706:
4702:
4695:
4687:
4683:
4679:
4675:
4671:
4667:
4663:
4659:
4652:
4633:
4626:
4620:
4618:
4616:
4607:
4603:
4598:
4593:
4589:
4585:
4581:
4574:
4566:
4562:
4558:
4554:
4550:
4546:
4538:
4536:
4527:
4523:
4519:
4515:
4511:
4507:
4504:(9): 732–47.
4503:
4499:
4498:CNS Spectrums
4492:
4484:
4477:
4461:
4457:
4451:
4447:
4446:
4438:
4430:
4423:
4419:
4414:
4409:
4406:(6): 871–80.
4405:
4401:
4397:
4390:
4382:
4378:
4374:
4368:
4352:
4348:
4346:
4340:
4334:
4315:
4311:
4307:
4300:
4293:
4274:
4270:
4266:
4259:
4252:
4236:
4232:
4231:
4226:
4219:
4211:
4207:
4203:
4199:
4195:
4191:
4184:
4176:
4172:
4168:
4164:
4160:
4156:
4149:
4141:
4137:
4133:
4129:
4125:
4121:
4117:
4113:
4106:
4090:
4086:
4085:
4080:
4074:
4066:
4062:
4058:
4054:
4050:
4046:
4043:(4): 242–54.
4042:
4038:
4030:
4022:
4018:
4014:
4010:
4006:
4002:
3994:
3992:
3983:
3979:
3974:
3969:
3965:
3961:
3957:
3953:
3949:
3942:
3926:
3922:
3918:
3912:
3910:
3901:
3897:
3893:
3889:
3885:
3881:
3878:(5): 365–75.
3877:
3873:
3866:
3858:
3854:
3849:
3844:
3840:
3836:
3833:(5): 613–20.
3832:
3828:
3824:
3817:
3808:
3800:
3796:
3792:
3788:
3784:
3780:
3777:(2): 99–106.
3776:
3772:
3765:
3749:
3745:
3741:
3735:
3727:
3723:
3719:
3715:
3710:
3705:
3701:
3697:
3693:
3686:
3670:
3666:
3660:
3652:
3648:
3642:
3631:
3624:
3618:
3610:
3606:
3602:
3598:
3594:
3590:
3587:(3): 679–86.
3586:
3582:
3575:
3567:
3563:
3558:
3553:
3549:
3545:
3541:
3537:
3533:
3526:
3519:
3518:
3513:
3508:
3492:
3488:
3486:
3480:
3474:
3458:
3454:
3452:
3446:
3440:
3432:
3428:
3423:
3418:
3413:
3408:
3404:
3400:
3396:
3389:
3381:
3377:
3373:
3369:
3365:
3361:
3357:
3353:
3345:
3329:
3325:
3323:
3317:
3311:
3295:
3291:
3290:Eli Lilly Co.
3287:
3281:
3273:
3269:
3265:
3261:
3257:
3253:
3246:
3238:
3234:
3230:
3226:
3222:
3218:
3210:
3202:
3198:
3193:
3188:
3184:
3180:
3176:
3172:
3168:
3161:
3145:
3141:
3137:
3133:
3129:
3125:
3124:NIHR Evidence
3120:
3113:
3105:
3101:
3096:
3091:
3086:
3081:
3077:
3073:
3072:BMC Neurology
3069:
3062:
3054:
3050:
3046:
3042:
3035:
3027:
3023:
3018:
3013:
3009:
3005:
3001:
2997:
2993:
2986:
2970:
2963:
2957:
2949:
2945:
2940:
2935:
2932:(5): 346–56.
2931:
2927:
2926:Pain Medicine
2923:
2916:
2908:
2904:
2900:
2896:
2892:
2888:
2884:
2880:
2873:
2865:
2861:
2856:
2851:
2847:
2843:
2839:
2835:
2831:
2824:
2816:
2812:
2808:
2804:
2800:
2796:
2792:
2788:
2781:
2773:
2769:
2765:
2761:
2757:
2753:
2750:(6): 523–41.
2749:
2745:
2738:
2722:
2718:
2714:
2707:
2699:
2695:
2690:
2685:
2681:
2677:
2673:
2669:
2665:
2658:
2650:
2646:
2641:
2636:
2632:
2628:
2624:
2620:
2616:
2609:
2601:
2597:
2592:
2587:
2582:
2577:
2574:: 1005–1028.
2573:
2569:
2565:
2558:
2542:
2538:
2534:
2530:
2526:
2522:
2516:
2508:
2504:
2499:
2494:
2490:
2486:
2482:
2478:
2474:
2467:
2465:
2456:
2452:
2448:
2444:
2439:
2434:
2430:
2426:
2422:
2415:
2407:
2403:
2399:
2395:
2390:
2389:2027.42/84412
2385:
2381:
2377:
2373:
2369:
2361:
2353:
2349:
2345:
2341:
2337:
2333:
2329:
2326:(in German).
2325:
2318:
2310:
2306:
2302:
2298:
2293:
2288:
2284:
2280:
2276:
2269:
2261:
2257:
2252:
2247:
2243:
2239:
2235:
2231:
2227:
2220:
2213:
2212:
2207:
2202:
2187:
2183:
2177:
2161:
2157:
2153:
2147:
2139:
2137:9780857113382
2133:
2129:
2123:
2121:
2104:
2100:
2096:
2090:
2074:
2070:
2066:
2060:
2058:
2056:
2054:
2052:
2050:
2048:
2046:
2044:
2027:
2023:
2021:
2016:
2010:
2008:
2006:
1989:
1985:
1983:
1978:
1972:
1970:
1968:
1951:
1947:
1943:
1937:
1935:
1933:
1916:
1912:
1908:
1902:
1887:
1883:
1879:
1873:
1857:
1853:
1849:
1843:
1841:
1836:
1820:
1816:
1806:
1803:
1802:
1796:
1794:
1789:
1781:US$ 4 billion
1777:US$ 5 billion
1773:
1770:
1766:
1764:
1763:Health Canada
1759:
1754:
1751:
1746:
1742:
1738:
1734:
1729:
1727:
1723:
1719:
1715:
1711:
1702:
1693:
1689:
1687:
1683:
1682:interleukin 6
1680:(TNF-α), and
1679:
1675:
1670:
1659:
1656:
1654:
1650:
1646:
1644:
1640:
1638:
1634:
1628:
1619:
1617:
1613:
1608:
1606:
1595:
1593:
1587:
1586:
1582:
1580:
1574:
1573:
1569:
1567:
1561:
1560:
1556:
1554:
1551:
1550:
1546:
1544:
1541:
1540:
1536:
1534:
1531:
1530:
1522:
1519:
1518:
1502:
1500:
1496:
1492:
1488:
1484:
1480:
1476:
1472:
1468:
1464:
1460:
1456:
1452:
1448:
1438:
1434:
1432:
1428:
1423:
1413:
1409:
1406:
1402:
1398:
1394:
1392:
1388:
1384:
1380:
1376:
1372:
1368:
1364:
1360:
1356:
1352:
1346:
1336:
1334:
1333:hyperhidrosis
1324:
1321:
1316:
1312:
1307:
1297:
1295:
1291:
1287:
1283:
1279:
1274:
1272:
1269:are the main
1268:
1264:
1260:
1256:
1247:
1244:
1242:
1238:
1230:
1226:
1223:
1220:
1217:
1213:
1209:
1205:
1201:
1198:
1195:
1192:
1191:
1190:
1188:
1174:
1170:
1166:
1162:
1161:meta-analysis
1158:
1155:
1154:
1153:
1150:
1148:
1144:
1134:
1132:
1127:
1125:
1121:
1116:
1114:
1109:
1101:
1099:
1094:
1092:
1087:
1086:
1085:BMC Neurology
1080:
1076:
1072:
1068:
1067:amitriptyline
1064:
1060:
1055:
1053:
1052:serum glucose
1049:
1039:
1037:
1033:
1029:
1025:
1021:
1017:
1016:
1011:
1001:
999:
989:
986:
985:
980:
970:
968:
964:
959:
957:
953:
949:
945:
941:
931:
925:
920:
918:
914:
910:
906:
902:
898:
894:
889:
887:
883:
878:
876:
872:
868:
864:
860:
856:
852:
848:
838:
831:
825:
816:
811:
810:
807:
800:
791:
790:
787:
780:
773:
769:
768:
766:
763:
758:
751:
749:
745:
721:
719:
715:
710:
706:
702:
699:
697:
695:ECHA InfoCard
691:
683:
679:
678:DTXSID6048385
675:
674:
672:
663:
659:
651:
650:RCSB PDB
645:
640:
639:
637:
635:
631:
624:
623:ChEMBL1200328
620:as HCl:
619:
616:
612:
611:
609:
607:
603:
596:
592:as HCl:
591:
588:
584:
583:
581:
579:
575:
568:
564:as HCl:
563:
560:
556:
555:
553:
551:
547:
540:
536:as HCl:
535:
532:
528:
527:
525:
523:
519:
512:
508:
507:
505:
503:
499:
492:
488:
487:
485:
483:
479:
472:
468:
467:
465:
463:
459:
452:
448:
447:
445:
438:
434:
427:
423:as HCl:
422:
419:
415:
414:
412:
410:
406:
398:
394:
389:
388:
385:
378:
373:
369:
367:
363:
359:
357:
350:
347:
343:
339:
336:
334:
330:
326:
324:
320:
316:
314:
310:
306:
302:
296: Rx-only
289:
286:
274:
271:
261:
259:
250:
247:
237:
234:
224:
223:
221:
219:
215:
210:
202:
197:
194:
193:
191:
189:
185:
182:
179:
177:
173:
170:
167:
165:
159:
153:
144:
143:
141:
139:
133:
126:
121:
112:
111:
109:
107:
103:
99:
95:
93:
89:
85:
81:
79:
75:
71:
67:
65:
61:
58:Clinical data
56:
52:
47:
43:
38:
30:
26:
22:
9660:
9636:Bamlanivimab
9461:
9460:
9445:
9433:
9430:
9420:
9330:Bietaserpine
9302:Amphetamines
9225:Mifepristone
9215:Medifoxamine
9097:
9040:Clomipramine
9035:Cianopramine
9026:
8879:Diclofensine
8849:Brasofensine
8825:
8772:
8749:
8737:Vortioxetine
8688:
8607:Escitalopram
8563:
8485:Indeloxazine
8477:
8414:
8397:Oxaprotiline
8378:
8366:Trimipramine
8321:Clomipramine
8316:Cianopramine
8311:Butriptyline
8302:
8155:Diclofensine
8125:Brasofensine
8101:
8043:
8025:
8013:Solriamfetol
7939:
7922:Teniloxazine
7882:Esreboxetine
7853:
7785:Solriamfetol
7705:Medifoxamine
7595:Dimethocaine
7585:Diclofensine
7557:
7509:
7397:Difluoropine
7392:Dichloropane
7377:Brasofensine
7363:
7351:Pyrovalerone
7327:
7252:Piperidines:
7251:
7201:Piperazines:
7200:
7047:Cannabinoids
7032:Benfotiamine
6870:
6843:fibromyalgia
6742:Oxitriptan (
6734:
6618:aripiprazole
6576:
6525:Metralindole
6516:
6486:
6476:
6455:Pivhydrazine
6445:Pheniprazine
6391:
6297:Trimipramine
6287:Quinupramine
6187:Clomipramine
6182:Butriptyline
6105:Teniloxazine
6100:Tandospirone
6085:Metryptamine
6080:Medifoxamine
6065:Indeloxazine
6019:Vortioxetine
5838:
5781:Escitalopram
5683:. Retrieved
5679:the original
5674:
5664:
5652:. Retrieved
5648:the original
5644:FiercePharma
5643:
5633:
5621:. Retrieved
5617:the original
5613:FiercePharma
5612:
5602:
5590:. Retrieved
5582:News-Medical
5581:
5572:
5540:(7508): 70.
5537:
5533:
5523:
5511:. Retrieved
5507:the original
5497:
5485:. Retrieved
5481:the original
5471:
5459:. Retrieved
5455:the original
5448:
5439:
5429:29 September
5427:. Retrieved
5414:
5405:
5383:. Retrieved
5359:
5334:
5330:
5324:
5299:
5295:
5289:
5277:. Retrieved
5273:the original
5262:
5225:
5221:
5175:
5171:
5164:
5134:(4): e2698.
5131:
5127:
5120:
5095:
5091:
5084:
5052:(8): e2689.
5049:
5045:
5035:
5002:
4998:
4992:
4957:
4953:
4943:
4908:
4904:
4894:
4872:(3): 300–7.
4869:
4865:
4859:
4826:
4822:
4816:
4781:
4777:
4767:
4755:. Retrieved
4751:the original
4746:
4737:
4704:
4700:
4694:
4661:
4657:
4651:
4639:. Retrieved
4587:
4583:
4573:
4548:
4544:
4501:
4497:
4491:
4482:
4476:
4464:. Retrieved
4444:
4437:
4403:
4399:
4389:
4381:the original
4376:
4367:
4355:. Retrieved
4351:the original
4342:
4333:
4323:22 September
4321:. Retrieved
4305:
4292:
4282:22 September
4280:. Retrieved
4264:
4251:
4239:. Retrieved
4228:
4218:
4193:
4189:
4183:
4161:(1): 155–7.
4158:
4154:
4148:
4115:
4111:
4105:
4093:. Retrieved
4082:
4073:
4040:
4036:
4029:
4004:
4000:
3958:(4): 212–9.
3955:
3951:
3941:
3931:14 September
3929:. Retrieved
3920:
3875:
3871:
3865:
3830:
3826:
3816:
3807:
3774:
3770:
3764:
3754:18 September
3752:. Retrieved
3734:
3699:
3695:
3685:
3673:. Retrieved
3659:
3651:the original
3641:
3630:the original
3617:
3584:
3580:
3574:
3539:
3535:
3525:
3515:
3507:
3497:29 September
3495:. Retrieved
3482:
3473:
3461:. Retrieved
3457:the original
3448:
3439:
3402:
3398:
3388:
3358:(1): 83–93.
3355:
3351:
3344:
3334:30 September
3332:. Retrieved
3319:
3310:
3298:. Retrieved
3294:the original
3289:
3280:
3255:
3251:
3245:
3220:
3216:
3209:
3174:
3170:
3160:
3148:. Retrieved
3123:
3112:
3075:
3071:
3061:
3044:
3040:
3034:
3002:(7610): 87.
2999:
2995:
2985:
2973:. Retrieved
2956:
2929:
2925:
2915:
2882:
2878:
2872:
2837:
2833:
2823:
2790:
2786:
2780:
2747:
2743:
2737:
2725:. Retrieved
2716:
2706:
2671:
2667:
2657:
2625:: CD006533.
2622:
2618:
2608:
2571:
2567:
2557:
2545:. Retrieved
2528:
2524:
2515:
2480:
2476:
2428:
2424:
2414:
2374:(6): 910–7.
2371:
2367:
2360:
2327:
2323:
2317:
2282:
2278:
2268:
2233:
2229:
2219:
2209:
2201:
2189:. Retrieved
2185:
2176:
2164:. Retrieved
2155:
2146:
2127:
2107:. Retrieved
2098:
2089:
2077:. Retrieved
2068:
2065:"Duloxetine"
2032:30 September
2030:. Retrieved
2018:
1994:30 September
1992:. Retrieved
1980:
1956:29 September
1954:. Retrieved
1945:
1919:. Retrieved
1901:
1889:. Retrieved
1881:
1872:
1860:. Retrieved
1851:
1848:"Duloxetine"
1819:
1790:
1774:
1771:
1767:
1755:
1745:QTc interval
1730:
1707:
1690:
1665:
1657:
1648:
1647:
1642:
1641:
1637:Distribution
1636:
1635:
1626:
1625:
1609:
1601:
1505:Pharmacology
1479:hyponatremia
1455:anaphylactic
1444:
1435:
1419:
1410:
1407:
1403:
1399:
1395:
1363:paresthesias
1348:
1330:
1320:escitalopram
1303:
1288:(20.0%) and
1275:
1271:side effects
1253:
1245:
1234:
1229:thioridazine
1184:
1151:
1140:
1128:
1120:chronic pain
1117:
1110:
1107:
1095:
1083:
1078:
1056:
1045:
1024:escitalopram
1013:
1007:
995:
982:
976:
960:
956:fibromyalgia
937:
934:Medical uses
921:
890:
879:
867:fibromyalgia
850:
846:
845:
834:
828:
396:
392:
353:Elimination
218:Legal status
212:Legal status
106:License data
29:
9646:Baricitinib
9473:Adrenergics
9400:Valbenazine
9390:Rose bengal
9335:Deserpidine
9306:amphetamine
9256:levorphanol
9200:Dextrorphan
9153:ziprasidone
9135:pheniramine
9070:Lofepramine
9050:Desipramine
8999:Tesofensine
8989:Sibutramine
8964:Perafensine
8924:JNJ-7925476
8919:Indatraline
8864:Dasotraline
8834:Amifitadine
8813:Venlafaxine
8793:Milnacipran
8692:Etoperidone
8672:Seproxetine
8662:Pirandamine
8642:Omiloxetine
8622:Fluvoxamine
8582:Cericlamine
8572:Alaproclate
8519:levorphanol
8448:ziprasidone
8430:pheniramine
8402:Setiptiline
8387:Maprotiline
8346:Lofepramine
8326:Desipramine
8275:Tesofensine
8265:Sibutramine
8240:Perafensine
8200:JNJ-7925476
8195:Indatraline
8140:Dasotraline
8110:Amifitadine
8089:Venlafaxine
8064:Milnacipran
7993:Nomifensine
7958:Fencamfamin
7887:Lortalamine
7877:Edivoxetine
7867:Ciclazindol
7862:Alseroxylon
7810:Venlafaxine
7790:Tametraline
7780:Sibutramine
7755:Perafensine
7735:Nomifensine
7665:Indatraline
7640:Fencamfamin
7615:DOV-216,303
7610:DOV-102,677
7570:Dasotraline
7565:Ciclazindol
7523:Armodafinil
7518:Amifitadine
7467:Tesofensine
7275:Difemetorex
7087:hydrocodone
7005:desipramine
6967:lamotrigine
6951:mirogabalin
6875:milnacipran
6781:from market
6724:brexanolone
6638:risperidone
6535:Moclobemide
6517:Reversible:
6477:Reversible:
6400:Iproclozide
6335:Setiptiline
6330:Mirtazapine
6320:Maprotiline
6277:Propizepine
6262:Noxiptiline
6247:Metapramine
6237:Lofepramine
6207:Dimetacrine
6197:Desipramine
6070:Flupentixol
6055:Etryptamine
6040:Amisulpride
6035:Agomelatine
5981:Etoperidone
5958:Setiptiline
5953:Mirtazapine
5925:Nomifensine
5882:Atomoxetine
5859:Venlafaxine
5849:Milnacipran
5791:Fluvoxamine
5654:25 December
5623:25 December
5592:25 December
5487:27 February
5461:16 December
5178:: 394–409.
5046:Brain Behav
4357:16 December
4084:Mayo Clinic
2727:27 February
2109:25 February
2079:24 December
1862:24 December
1649:Elimination
1469:increased,
1465:increased,
1453:increased,
1449:increased,
1416:Suicidality
1036:venlafaxine
755: g·mol
701:100.116.825
595:CHEBI:31526
587:CHEBI:36795
426:136434-34-9
418:116539-59-4
375:Identifiers
92:MedlinePlus
64:Trade names
9879:Thiophenes
9858:Categories
9736:Jentadueto
9681:Etesevimab
9449:SoRI-20041
9442:SoRI-20040
9370:Ketanserin
9297:Amiodarone
9260:tapentadol
9220:Mesembrine
9190:Delucemine
9167:esketamine
9080:Pipofezine
9065:Imipramine
8984:SEP-228432
8979:SEP-228431
8949:Nefazodone
8934:Liafensine
8904:Fezolamine
8894:DOV-216303
8889:DOV-102677
8844:Bicifadine
8839:Ansofaxine
8778:Eclanamine
8773:Duloxetine
8758:Bicifadine
8732:Vilazodone
8702:Lubazodone
8697:Litoxetine
8682:Zimelidine
8677:Sertraline
8652:Paroxetine
8647:Panuramine
8617:Fluoxetine
8612:Femoxetine
8592:Dapoxetine
8587:Citalopram
8511:tapentadol
8490:Nefazodone
8473:Ephenidine
8468:Dopexamine
8351:Melitracen
8341:Imipramine
8260:SEP-228432
8255:SEP-228431
8225:Nefazodone
8210:Liafensine
8180:Fezolamine
8170:DOV-216303
8165:DOV-102677
8120:Bicifadine
8115:Ansofaxine
8074:Nafenodone
8049:Eclanamine
8044:Duloxetine
8003:Radafaxine
7983:Manifaxine
7968:Lefetamine
7943:Amineptine
7927:Viloxazine
7902:Reboxetine
7897:Nisoxetine
7775:Sertraline
7765:Radafaxine
7750:Oroxylin A
7695:Manifaxine
7685:Liafensine
7675:Lefetamine
7655:GYKI-52895
7645:Fezolamine
7630:Esketamine
7625:Ephenidine
7548:BTS 74,398
7538:Ansofaxine
7533:Amineptine
7412:FP-β-CPPIT
7407:FE-β-CPPIT
7346:Prolintane
7239:Vanoxerine
7234:Nefazodone
7111:tapentadol
7055:dronabinol
7011:Ziconotide
6983:Mexiletine
6963:lacosamide
6947:pregabalin
6943:gabapentin
6916:tapentadol
6871:duloxetine
6756:Tryptophan
6728:zuranolone
6634:quetiapine
6630:olanzapine
6626:lurasidone
6580:Selegiline
6570:-selective
6550:Toloxatone
6545:Tetrindole
6540:Pirlindole
6520:Eprobemide
6510:-selective
6490:Bifemelane
6480:Caroxazone
6440:Phenelzine
6425:Mebanazine
6405:Iproniazid
6292:Tianeptine
6272:Pipofezine
6242:Melitracen
6222:Imipramine
6202:Dibenzepin
6162:Amineptine
6110:Tianeptine
6095:Pivagabine
6090:Oxaflozane
6050:Esketamine
6014:Vilazodone
5986:Nefazodone
5915:Amineptine
5892:Viloxazine
5887:Reboxetine
5839:Duloxetine
5811:Zimelidine
5806:Sertraline
5801:Paroxetine
5786:Fluoxetine
5776:Citalopram
5445:"FDA news"
5228:(1): 181.
4784:: 113–25.
4641:1 November
4466:20 October
2568:J Pain Res
1891:22 October
1831:References
1726:enantiomer
1714:fluoxetine
1643:Metabolism
1627:Absorption
1605:metabolism
1457:reaction,
1387:withdrawal
1311:anorgasmia
1259:somnolence
1100:patients.
1063:imipramine
1032:paroxetine
1028:sertraline
1020:citalopram
950:, chronic
847:Duloxetine
760:3D model (
748:Molar mass
634:PDB ligand
615:ChEMBL1175
539:9044SC542W
531:O5TNM5N07U
502:ChemSpider
462:IUPHAR/BPS
409:CAS Number
384:IUPAC name
333:Metabolism
176:Drug class
125:Duloxetine
34:Duloxetine
21:Dapoxetine
9806:Trulicity
9796:Tradjenta
9776:Strattera
9756:Portrazza
9726:Jardiance
9716:Humatrope
9542:directors
9539:Corporate
9462:See also:
9437:SoRI-9804
9385:Reserpine
9355:GBR-12935
9350:Efavirenz
9270:Roxindole
9248:methadone
9235:N-Me-5-HT
9205:Efavirenz
9163:3-MeO-PCP
9106:Amoxapine
8974:Pridefine
8944:Naphyrone
8808:Tofenacin
8727:Trazodone
8717:SB-649915
8712:Quipazine
8707:LY-393558
8632:Ifoxetine
8627:Indalpine
8503:methadone
8392:Mianserin
8382:Amoxapine
8250:Pridefine
8220:Naphyrone
8084:Tofenacin
8034:CP-39,332
7953:Fencamine
7948:Bupropion
7917:Tandamine
7912:Talsupram
7872:Daledalin
7770:Rimcazole
7760:Pridefine
7725:Modafinil
7650:Fluorenol
7620:Efavirenz
7553:Bupropion
7513:Adrafinil
7477:Tropoxane
7367:Altropane
7364:Tropanes:
7341:Naphyrone
7305:Pipradrol
7224:GBR-13098
7219:GBR-13069
7214:GBR-12935
7209:GBR-12783
7099:methadone
7095:oxycodone
7077:methadone
7042:Bupropion
6977:lidocaine
6898:dosulepin
6791:Phase III
6779:Withdrawn
6644:Buspirone
6530:Minaprine
6465:Tedizolid
6460:Safrazine
6435:Octamoxin
6430:Nialamide
6420:Linezolid
6415:Isoniazid
6325:Mianserin
6267:Opipramol
6232:Iprindole
6212:Dosulepin
6177:Amoxapine
6133:Tricyclic
5991:Trazodone
5948:Mianserin
5920:Bupropion
5854:Tofenacin
5796:Indalpine
5745:Specific
5685:2 January
5200:235620244
5156:163168228
4778:Brain Res
4686:207299455
4140:184484229
4095:1 October
3921:Drugs.com
3799:264888110
3463:19 August
3217:CNS Drugs
3140:258013544
2744:CNS Drugs
2230:Neurology
2191:30 August
2166:30 August
2069:Monograph
1921:16 August
1852:Drugs.com
1676:(IL-1β),
1499:urticaria
1467:bilirubin
1379:hypomania
1367:brain zap
1315:anhedonia
1290:dizziness
1284:(22.7%),
1282:dry mouth
1280:(34.7%),
1267:dizziness
1212:mydriasis
1164:subjects.
1111:The U.S.
984:Prescrire
917:pregnancy
893:dry mouth
366:Excretion
355:half-life
162:Routes of
136:Pregnancy
84:Monograph
78:Drugs.com
9848:Medicine
9811:Verzenio
9801:Trijardy
9786:Synjardy
9751:Olumiant
9731:Jaypirca
9706:Glyxambi
9701:Glucagon
9671:Emgality
9661:Cymbalta
9651:Basaglar
9614:Products
9424:Luteolin
9375:Lobeline
9365:Ibogaine
9264:tramadol
9210:Hypidone
9171:ketamine
9149:loxapine
9009:Tropanes
8939:Mazindol
8929:JZ-IV-10
8763:CP-39332
8722:TGBA01AD
8515:tramadol
8458:ketamine
8444:loxapine
8285:Tropanes
8215:Mazindol
8205:JZ-IV-10
7907:Talopram
7892:Mazindol
7857:Amedalin
7715:Metaphit
7710:Mesocarb
7700:Mazindol
7670:Ketamine
7472:Troparil
7229:JJC8-088
7107:tramadol
7091:morphine
7069:ketamine
7059:nabilone
7051:cannabis
6920:tramadol
6717:GABAkine
6395:Benmoxin
6351:Tiazesim
6075:Ketamine
6060:Gepirone
5586:Archived
5564:16002878
5423:Archived
5376:Archived
5351:14643350
5254:38481321
5245:10936099
5192:34174336
5148:31125145
5112:26556688
5076:35791513
5019:10767254
4984:21796103
4927:20646337
4886:22981313
4851:22275879
4843:17433516
4808:25003554
4757:21 March
4729:22045964
4721:18651344
4678:21366359
4632:Archived
4606:28913467
4565:15892657
4526:40022100
4518:16142213
4460:Archived
4422:11750180
4314:Archived
4273:Archived
4235:Archived
4210:16266753
4175:19664885
4132:25576334
4089:Archived
4065:23153099
4057:22121997
4021:17627739
3982:16964316
3925:Archived
3900:12208795
3892:19454869
3857:16700869
3791:37918778
3771:Am J Med
3748:Archived
3718:17577103
3669:Archived
3609:10788312
3601:23504618
3566:28246265
3491:Archived
3431:24618328
3380:20599116
3372:22314118
3328:Archived
3272:19137126
3237:38421578
3201:36007534
3150:28 April
3144:Archived
3104:18673529
3053:17121211
3026:17562735
2975:14 April
2948:16266355
2907:10291281
2899:15927394
2864:37670573
2855:10695723
2815:42889106
2807:24297210
2772:30897102
2764:19480470
2721:Archived
2698:29477251
2649:23076926
2600:38505500
2591:10949339
2541:Archived
2537:25121155
2507:24385423
2498:10711341
2455:14236933
2447:20402746
2406:15020212
2398:21484835
2344:22760463
2309:11183183
2301:24733808
2260:21482920
2186:ClinCalc
2160:Archived
2156:ClinCalc
2103:Archived
2073:Archived
2026:Archived
1988:Archived
1950:Archived
1946:DailyMed
1915:Archived
1856:Archived
1799:See also
1669:cytokine
1618:uptake.
1537:0.7~0.8
1520:Receptor
1483:jaundice
1471:glaucoma
1383:tinnitus
1375:insomnia
1365:such as
1294:headache
1286:headache
1263:insomnia
1237:triptans
1216:glaucoma
1204:glaucoma
979:Cochrane
884:(SNRI).
851:Cymbalta
837:(verify)
482:DrugBank
360:12 hours
246:Class C1
188:ATC code
169:By mouth
151: B3
138:category
120:DailyMed
25:Dulcolax
9821:Zyprexa
9781:Symbyax
9766:Retevmo
9746:Lyumjev
9741:Kisunla
9721:Humulin
9711:Humalog
9676:Erbitux
9666:Cyramza
9641:Baqsimi
9621:Adcirca
9360:GZ-793A
9304:(e.g.,
9242:(e.g.,
9240:Opioids
9161:(e.g.,
9147:(e.g.,
9113:(e.g.,
9101:A-80426
9098:Others:
9060:Doxepin
9013:cocaine
9011:(e.g.,
8959:NS-2359
8954:Nefopam
8909:HDMP-28
8899:EXP-561
8859:Cocaine
8788:McN5652
8667:RTI-353
8497:(e.g.,
8495:Opioids
8456:(e.g.,
8442:(e.g.,
8420:(e.g.,
8415:Others:
8336:Doxepin
8289:cocaine
8287:(e.g.,
8235:NS-2359
8230:Nefopam
8185:HDMP-28
8175:EXP-561
8135:Cocaine
8059:McN5652
7978:LR-5182
7740:NS-2359
7730:Nefopam
7690:LR-5182
7635:EXP-561
7510:Others:
7462:RTI-336
7457:RTI-229
7452:RTI-177
7447:RTI-150
7442:RTI-126
7437:RTI-121
7432:RTI-113
7427:RTI-112
7387:Cocaine
7285:HDMP-28
7204:DBL-583
7085:(e.g.,
7083:Opioids
7067:(e.g.,
7049:(e.g.,
6995:(e.g.,
6975:(e.g.,
6941:(e.g.,
6914:(e.g.,
6888:(e.g.,
6869:(e.g.,
6649:Lithium
6217:Doxepin
5749:and/or
5316:2850421
5067:9392519
5027:2267250
4975:3194072
4799:4284141
4597:5505372
4308:. U.S.
4267:. U.S.
3973:1557468
3848:1473178
3742:. U.S.
3726:2356196
3557:5289870
3422:4007556
3300:17 June
3192:9418415
3095:2529342
3017:1914460
2967:. U.S.
2689:5889788
2640:4169791
2547:28 June
2352:1348989
2324:Schmerz
2251:3100130
1722:racemic
1696:History
1495:syncope
1159:A 2013
1075:opioids
998:placebo
977:A 2014
897:suicide
718:Formula
491:DB00476
437:PubChem
287:Rx-only
284:WARNING
256::
204:)
198: (
196:N06AX21
122::
98:a604030
9834:Portal
9816:Xigris
9771:Reyvow
9761:Prozac
9696:Gemzar
9691:Forteo
9686:Evista
9656:Cialis
9631:Amyvid
9626:Alimta
9414:Others
8969:PRC200
8914:HP-505
8657:PIM-35
8245:PRC200
8190:HP-505
7998:O-2172
7745:O-2172
7422:RTI-55
7020:Others
6904:Opioid
6774:WHO-EM
6487:Mixed:
6344:Others
6028:Others
5936:NaSSAs
5562:
5555:558648
5552:
5513:18 May
5385:18 May
5349:
5314:
5279:17 May
5252:
5242:
5198:
5190:
5154:
5146:
5110:
5074:
5064:
5025:
5017:
4982:
4972:
4935:656023
4933:
4925:
4884:
4849:
4841:
4806:
4796:
4727:
4719:
4684:
4676:
4604:
4594:
4563:
4524:
4516:
4452:
4420:
4241:13 May
4208:
4173:
4138:
4130:
4063:
4055:
4019:
3980:
3970:
3898:
3890:
3855:
3845:
3797:
3789:
3724:
3716:
3675:15 May
3607:
3599:
3564:
3554:
3429:
3419:
3405:: 76.
3378:
3370:
3270:
3235:
3199:
3189:
3171:Lancet
3138:
3102:
3092:
3078:: 29.
3051:
3024:
3014:
2946:
2905:
2897:
2862:
2852:
2813:
2805:
2770:
2762:
2696:
2686:
2668:Lancet
2647:
2637:
2598:
2588:
2535:
2505:
2495:
2453:
2445:
2404:
2396:
2350:
2342:
2307:
2299:
2258:
2248:
2134:
1278:nausea
1265:, and
1255:Nausea
1034:, and
954:, and
928:
907:, and
786:SMILES
753:297.42
606:ChEMBL
567:D01179
559:D07880
346:CYP1A2
342:CYP2D6
281:
268:
258:â„ž-only
244:
231:
118:
9791:Taltz
9285:VMATs
7497:WF-33
7492:WF-31
7487:WF-23
7482:WF-11
6863:SNRIs
6744:5-HTP
6308:TeCAs
5969:SARIs
5903:NDRIs
5822:SNRIs
5764:SSRIs
5419:(FDA)
5415:U.S.
5379:(PDF)
5368:(PDF)
5196:S2CID
5152:S2CID
5023:S2CID
4999:Chest
4931:S2CID
4847:S2CID
4725:S2CID
4682:S2CID
4635:(PDF)
4628:(PDF)
4522:S2CID
4347:(FDA)
4343:U.S.
4317:(PDF)
4302:(PDF)
4276:(PDF)
4261:(PDF)
4136:S2CID
4061:S2CID
3896:S2CID
3795:S2CID
3722:S2CID
3633:(PDF)
3626:(PDF)
3605:S2CID
3487:(FDA)
3483:U.S.
3453:(FDA)
3449:U.S.
3376:S2CID
3324:(FDA)
3320:U.S.
3136:S2CID
2965:(PDF)
2903:S2CID
2811:S2CID
2768:S2CID
2451:S2CID
2402:S2CID
2348:S2CID
2305:S2CID
2022:(EMA)
1984:(EMA)
1614:than
1527:(nM)
1355:SNRIs
1351:SSRIs
1206:: in
1122:from
905:mania
806:InChI
762:JSmol
641:29E (
578:ChEBI
511:54822
451:60835
391:(+)-(
338:Liver
327:~ 95%
9325:AZIK
9314:MDMA
8803:PPPA
8546:SRIs
8535:SERT
8079:PPPA
7836:NRIs
7336:MDPV
7183:DRIs
6989:TCAs
6908:MRIs
6882:TCAs
6841:and
6710:SAMe
6150:TCAs
6135:and
5870:NRIs
5732:N06A
5687:2014
5656:2013
5625:2013
5594:2013
5560:PMID
5515:2008
5489:2015
5463:2019
5431:2020
5387:2008
5347:PMID
5312:PMID
5281:2008
5250:PMID
5188:PMID
5144:PMID
5108:PMID
5072:PMID
5015:PMID
4980:PMID
4923:PMID
4882:PMID
4839:PMID
4804:PMID
4782:1617
4759:2020
4717:PMID
4674:PMID
4643:2005
4602:PMID
4561:PMID
4514:PMID
4468:2020
4450:ISBN
4418:PMID
4359:2019
4325:2007
4284:2007
4243:2007
4206:PMID
4171:PMID
4128:PMID
4097:2023
4053:PMID
4017:PMID
3978:PMID
3933:2018
3888:PMID
3853:PMID
3787:PMID
3756:2013
3714:PMID
3677:2010
3597:PMID
3562:PMID
3536:CMAJ
3499:2020
3465:2013
3427:PMID
3368:PMID
3336:2020
3302:2008
3268:PMID
3233:PMID
3197:PMID
3152:2023
3100:PMID
3049:PMID
3022:PMID
2977:2009
2944:PMID
2895:PMID
2879:Pain
2860:PMID
2803:PMID
2760:PMID
2729:2015
2694:PMID
2645:PMID
2596:PMID
2549:2014
2533:PMID
2503:PMID
2443:PMID
2394:PMID
2340:PMID
2297:PMID
2256:PMID
2193:2024
2168:2024
2132:ISBN
2111:2024
2081:2018
2034:2020
1996:2020
1958:2020
1923:2023
1893:2023
1864:2018
1596:419
1589:5-HT
1583:916
1576:5-HT
1570:504
1563:5-HT
1557:240
1547:7.5
1533:SERT
1353:and
1073:and
1065:and
873:and
644:PDBe
550:KEGG
522:UNII
344:and
307:data
74:AHFS
9320:APP
7825:NET
7543:BTQ
7382:CFT
7172:DAT
7119:GHB
6673:),
6561:MAO
6501:MAO
6002:SMS
5550:PMC
5542:doi
5538:331
5534:BMJ
5339:doi
5304:doi
5240:PMC
5230:doi
5180:doi
5136:doi
5100:doi
5062:PMC
5054:doi
5007:doi
5003:117
4970:PMC
4962:doi
4913:doi
4874:doi
4870:145
4831:doi
4794:PMC
4786:doi
4709:doi
4666:doi
4592:PMC
4553:doi
4506:doi
4408:doi
4198:doi
4163:doi
4120:doi
4116:127
4045:doi
4009:doi
3968:PMC
3960:doi
3880:doi
3843:PMC
3835:doi
3779:doi
3775:137
3704:doi
3589:doi
3552:PMC
3544:doi
3540:189
3417:PMC
3407:doi
3360:doi
3356:124
3260:doi
3225:doi
3187:PMC
3179:doi
3175:400
3128:doi
3090:PMC
3080:doi
3012:PMC
3004:doi
3000:335
2996:BMJ
2934:doi
2887:doi
2883:116
2850:PMC
2842:doi
2795:doi
2791:159
2752:doi
2684:PMC
2676:doi
2672:391
2635:PMC
2627:doi
2586:PMC
2576:doi
2493:PMC
2485:doi
2433:doi
2384:hdl
2376:doi
2332:doi
2287:doi
2246:PMC
2238:doi
1886:FDA
1631:max
1553:DAT
1543:NET
667:EPA
471:202
441:CID
270:POM
201:WHO
23:or
9860::
9487:•
9483:•
9479:•
9475:•
9471:•
9467:•
9444:;
9312:,
9308:,
9262:,
9258:,
9254:,
9250:,
9246:,
9177:,
9173:,
9169:,
9165:,
9151:,
9137:,
9133:,
9129:,
9125:,
9121:,
9117:,
8517:,
8513:,
8509:,
8505:,
8501:,
8460:,
8446:,
8432:,
8428:,
8424:,
7109:,
7105:,
7101:,
7097:,
7093:,
7089:,
7075:,
7071:,
7057:,
7053:,
7003:,
6999:,
6965:,
6961:,
6957:,
6953:,
6949:,
6945:,
6918:,
6896:,
6892:,
6873:,
6787::
6726:,
6681:))
6677:(T
6669:(T
6655:,
6636:,
6632:,
6628:,
6624:,
6620:,
5673:.
5642:.
5611:.
5580:.
5558:.
5548:.
5536:.
5532:.
5447:.
5413:.
5345:.
5335:13
5333:.
5310:.
5300:43
5298:.
5248:.
5238:.
5226:19
5224:.
5220:.
5208:^
5194:.
5186:.
5176:97
5174:.
5150:.
5142:.
5132:34
5130:.
5106:.
5096:16
5094:.
5070:.
5060:.
5050:12
5048:.
5044:.
5021:.
5013:.
5001:.
4978:.
4968:.
4958:36
4956:.
4952:.
4929:.
4921:.
4909:23
4907:.
4903:.
4880:.
4868:.
4845:.
4837:.
4827:31
4825:.
4802:.
4792:.
4780:.
4776:.
4745:.
4723:.
4715:.
4705:41
4703:.
4680:.
4672:.
4662:50
4660:.
4630:.
4614:^
4600:.
4588:22
4586:.
4582:.
4559:.
4549:11
4547:.
4534:^
4520:.
4512:.
4502:10
4500:.
4458:.
4416:.
4404:25
4402:.
4398:.
4375:.
4341:.
4304:.
4263:.
4233:.
4227:.
4204:.
4194:89
4192:.
4169:.
4159:74
4157:.
4134:.
4126:.
4114:.
4087:.
4081:.
4059:.
4051:.
4041:15
4039:.
4015:.
4003:.
3990:^
3976:.
3966:.
3954:.
3950:.
3923:.
3919:.
3908:^
3894:.
3886:.
3876:25
3874:.
3851:.
3841:.
3831:60
3829:.
3825:.
3793:.
3785:.
3773:.
3720:.
3712:.
3700:49
3698:.
3694:.
3667:.
3603:.
3595:.
3585:45
3583:.
3560:.
3550:.
3538:.
3534:.
3514:.
3481:.
3447:.
3425:.
3415:.
3403:15
3401:.
3397:.
3374:.
3366:.
3354:.
3326:.
3318:.
3288:.
3266:.
3256:44
3254:.
3231:.
3221:38
3219:.
3195:.
3185:.
3173:.
3169:.
3142:.
3134:.
3122:.
3098:.
3088:.
3074:.
3070:.
3045:15
3043:.
3020:.
3010:.
2998:.
2994:.
2942:.
2928:.
2924:.
2901:.
2893:.
2881:.
2858:.
2848:.
2838:47
2836:.
2832:.
2809:.
2801:.
2789:.
2766:.
2758:.
2748:23
2746:.
2719:.
2715:.
2692:.
2682:.
2670:.
2666:.
2643:.
2633:.
2623:10
2621:.
2617:.
2594:.
2584:.
2572:17
2570:.
2566:.
2539:.
2529:23
2527:.
2523:.
2501:.
2491:.
2479:.
2475:.
2463:^
2449:.
2441:.
2429:17
2427:.
2423:.
2400:.
2392:.
2382:.
2372:43
2370:.
2346:.
2338:.
2328:26
2303:.
2295:.
2283:32
2281:.
2277:.
2254:.
2244:.
2234:76
2232:.
2228:.
2208:.
2184:.
2158:.
2154:.
2119:^
2101:.
2097:.
2067:.
2042:^
2017:.
2004:^
1979:.
1966:^
1948:.
1944:.
1931:^
1884:.
1880:.
1854:.
1850:.
1839:^
1795:.
1578:2C
1565:2A
1501:.
1493:,
1485:,
1481:,
1477:,
1473:,
1461:,
1393:.
1381:,
1377:,
1373:,
1261:,
1257:,
1243:.
1147:UK
1126:.
1054:.
1038:.
1030:,
1026:,
1022:,
969:.
958:.
946:,
942:,
911:.
903:,
899:,
869:,
865:,
861:,
857:,
732:19
726:18
647:,
395:)-
292:EU
277:US
264:UK
253:CA
240:BR
233:S4
227:AU
147:AU
115:US
9836::
9523:e
9516:t
9509:v
9316:)
9266:)
9181:)
9155:)
9141:)
9015:)
8552:)
8543:(
8521:)
8464:)
8450:)
8436:)
8291:)
7842:)
7833:(
7189:)
7180:(
7155:e
7148:t
7141:v
7121:)
7113:)
7079:)
7061:)
7007:)
6979:)
6969:)
6922:)
6900:)
6877:)
6831:e
6824:t
6817:v
6746:)
6730:)
6722:(
6712:)
6679:4
6671:3
6665:(
6659:)
6651:(
6640:)
6616:(
6563:B
6503:A
5734:)
5730:(
5720:e
5713:t
5706:v
5689:.
5658:.
5627:.
5596:.
5566:.
5544::
5517:.
5491:.
5465:.
5433:.
5400:.
5389:.
5353:.
5341::
5318:.
5306::
5283:.
5256:.
5232::
5202:.
5182::
5158:.
5138::
5114:.
5102::
5078:.
5056::
5029:.
5009::
4986:.
4964::
4937:.
4915::
4888:.
4876::
4853:.
4833::
4810:.
4788::
4761:.
4731:.
4711::
4688:.
4668::
4645:.
4608:.
4567:.
4555::
4528:.
4508::
4470:.
4424:.
4410::
4361:.
4327:.
4286:.
4245:.
4212:.
4200::
4177:.
4165::
4142:.
4122::
4099:.
4067:.
4047::
4023:.
4011::
4005:4
3984:.
3962::
3956:8
3935:.
3902:.
3882::
3859:.
3837::
3801:.
3781::
3758:.
3728:.
3706::
3679:.
3611:.
3591::
3568:.
3546::
3501:.
3467:.
3433:.
3409::
3382:.
3362::
3338:.
3304:.
3274:.
3262::
3239:.
3227::
3203:.
3181::
3154:.
3130::
3106:.
3082::
3076:8
3055:.
3028:.
3006::
2979:.
2950:.
2936::
2930:6
2909:.
2889::
2866:.
2844::
2817:.
2797::
2774:.
2754::
2731:.
2700:.
2678::
2651:.
2629::
2602:.
2578::
2551:.
2509:.
2487::
2481:1
2457:.
2435::
2408:.
2386::
2378::
2354:.
2334::
2311:.
2289::
2262:.
2240::
2195:.
2170:.
2140:.
2113:.
2083:.
2036:.
1998:.
1960:.
1925:.
1895:.
1866:.
1591:6
1525:i
1523:K
1061:(
764:)
741:S
738:O
735:N
729:H
723:C
669:)
665:(
653:)
397:N
393:S
294::
279::
266::
242::
229::
149::
76:/
27:.
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
