642:
619:
40:
7540:
31:
1228:, an enzyme involved in the proliferation of cancer cells but not normal cells. However, potential side effects of orlistat, such as inhibition of other cellular off-targets or poor bioavailability, might hamper its application as an effective antitumor agent. One profiling study undertook a chemical proteomics approach to look for new cellular targets of orlistat, including its off-targets. Orlistat also shows potential activity against the
1163:
7568:
1063:
amongst those taking orlistat in early, pooled clinical trial data—the analysis of which delayed FDA review of orlistat—a two-year study published in 1999 found similar rates between orlistat and placebo (0.54% versus 0.51%), and evidence that tumors predated treatment in 3 of the 4 participants who
1015:
and frequent or urgent bowel movements. To minimize these effects, foods with high fat content should be avoided; the manufacturer advises consumers to follow a low-fat, reduced-calorie diet. Oily stools and flatulence can be controlled by reducing the dietary fat content to somewhere in the region
1329:) and Xenalten (OBL-Pharm). In Austria, orlistat is available under the brand name Slimox. In Malaysia, orlistat is available under the brand name Cuvarlix and is marketed by Pharmaniaga. In the Philippines orlistat is available under the brand name RedoXfat Plus manufactured by ATC Healthcare
1049:
The incidence of acute liver injury was higher in the periods both immediately before and immediately after the start of orlistat treatment. This suggests that the observed increased risks of liver injury linked to the start of treatment may reflect changes in health status associated with the
1304:
At least since
September 2017, tablets with 60 mg orlistat can be freely sold in Swiss drugstores. Formulations with 120 mg per tablet require a prescription, but can be sold without one in pharmacies under an exemption rule, which is based on a list of easily diagnosable diseases.
2257:
Menendez JA, Vellon L, Lupu R (August 2005). "Antitumoral actions of the anti-obesity drug orlistat (XenicalTM) in breast cancer cells: blockade of cell cycle progression, promotion of apoptotic cell death and PEA3-mediated transcriptional repression of Her2/neu (erbB-2) oncogene".
2069:
913:
number of subjects regained weight—up to 35% of the weight they had lost. It reduces the incidence of diabetes type II in people who are obese around the same amount that lifestyle changes do. Long-term use of orlistat also leads to a very modest reduction in
1320:
Generic orlistat is available in Iran under the brand
Venustat manufactured by Aburaihan Pharmaceutical co., in India, under the brands Orlean (Eris), Vyfat, Olistat, Obelit, Orlica and Reeshape. In Russia, orlistat is available under the brand names Xenical
2606:
2293:
Garcia SB, Barros LT, Turatti A, Martinello F, Modiano P, Ribeiro-Silva A, et al. (August 2006). "The anti-obesity agent
Orlistat is associated to increase in colonic preneoplastic markers in rats treated with a chemical carcinogen".
3122:
Boehm MF, McClurg MR, Pathirana C, Mangelsdorf D, White SK, Hebert J, et al. (February 1994). "Synthesis of high specific activity -9-cis-retinoic acid and its application for identifying retinoids with unusual binding properties".
1088:
carcinogenesis. In 2006 the results of 30-day study were published indicating that orlistat at a dosage of 200 mg/kg chow administered to rats consuming a high-fat chow and receiving two 25 mg/kg doses of the potent carcinogen
909:, between 35.5% and 54.8% of subjects achieved a 5% or greater decrease in body mass, although not all of this mass was necessarily fat. Between 16.4% and 24.8% achieved at least a 10% decrease in body fat. After orlistat was stopped, a
1265:, but withdrew its authorization of direct-to-consumer Xenical advertising, stating this "increased pressure on pharmacists to provide orlistat to consumers...this in turn had the potential to result in inappropriate patterns of use".
853:
suggest that people given orlistat in addition to lifestyle modifications, such as diet and exercise, lose about 2–3 kilograms (4–7 lb) more than those not taking the drug over the course of a year. Orlistat also modestly reduces
2370:
Zhi J, Moore R, Kanitra L, Mulligan TE (April 2003). "Effects of orlistat, a lipase inhibitor, on the pharmacokinetics of three highly lipophilic drugs (amiodarone, fluoxetine, and simvastatin) in healthy volunteers".
2061:
1023:
Side effects are most severe when beginning therapy and may decrease in frequency with time; It has also been suggested that the decrease in side effects over time may be associated with long-term compliance with a
3202:
Yang PY, Wang M, Liu K, Ngai MH, Sheriff O, Lear MJ, et al. (July 2012). "Parasite-based screening and proteome profiling reveal orlistat, an FDA-approved drug, as a potential anti
Trypanosoma brucei agent".
877:(oily, loose stools). They decrease with time, however, and are the most frequently reported adverse effects of the drug. In Australia, the United States and the European Union, orlistat is available for sale
1277:
in April 1999 as a prescription-only medication. On 23 January 2006, an FDA advisory panel voted 11 to 3 to recommend the approval of an OTC formulation of orlistat, to be sold under the brand name Alli by
708:
1045:
A study from 2013 looked at 94,695 participants receiving orlistat in the UK between 1999 and 2011. The study showed no evidence of an increased risk of liver injury during treatment. They concluded:
1258:
4947:
1225:
3173:
Yang PY, Liu K, Ngai MH, Lear MJ, Wenk MR, Yao SQ (January 2010). "Activity-based proteome profiling of potential cellular targets of
Orlistat--an FDA-approved drug with anti-tumor activities".
2194:
1282:. Approval was granted on 7 February 2007, and Alli became the first weight loss drug officially sanctioned by the U.S. government for over-the-counter use. Consumer advocacy organization
251:
155:
5804:
3079:
Glaxo said the issue wasn't a lack of interested buyers, but manufacturing problems that have led to shortages of the diet pill and forced the company to delay the product's sale.
2657:
6749:
1035:(FDA) approved a revised label for Xenical to include new safety information about cases of severe liver injury that have been reported rarely with the use of this medication.
893:
formulations of orlistat are available in some countries. In
Australia it has been listed as an S3 medication, available from a pharmacist without a prescription, since 2000.
862:, whether from the weight loss itself or other effects. It reduces the incidence of diabetes type II in people who are obese around the same amount that lifestyle changes do.
1878:
750:
InChI=1S/C29H53NO5/c1-5-7-9-11-12-13-14-15-16-18-24(34-29(33)26(30-22-31)20-23(3)4)21-27-25(28(32)35-27)19-17-10-8-6-2/h22-27H,5-21H2,1-4H3,(H,30,31)/t24-,25-,26-,27-/m0/s1
1525:
1492:
6025:
6015:
5551:
5420:
4049:
2824:
1607:
Zhi J, Melia AT, Eggers H, Joly R, Patel IH (November 1995). "Review of limited systemic absorption of orlistat, a lipase inhibitor, in healthy human volunteers".
1342:
At times, such as in spring 2012, orlistat has come into short supply, with consequent price increases because of nonavailability of one of the drug's components.
1262:
5840:
6030:
1760:"Pharmacological and lifestyle interventions to prevent or delay type 2 diabetes in people with impaired glucose tolerance: systematic review and meta-analysis"
2454:
Pemble CW, Johnson LC, Kridel SJ, Lowther WT (August 2007). "Crystal structure of the thioesterase domain of human fatty acid synthase inhibited by
Orlistat".
5730:
206:
5797:
5083:
4757:
6010:
2996:
2418:
2091:
Weir MA, Beyea MM, Gomes T, Juurlink DN, Mamdani M, Blake PG, et al. (April 2011). "Orlistat and acute kidney injury: an analysis of 953 patients".
1213:, and instead are excreted unchanged. Only trace amounts of orlistat are absorbed systemically; the primary effect is local lipase inhibition within the
1144:
5144:
3273:
766:
6679:
3066:
2910:
1070:
study to suggest that the introduction of specific varied preparations containing orlistat, namely the concurrent administration of orlistat and the
2184:
1853:
1354:
issued an alert stating that some counterfeit versions of Alli sold over the
Internet contain no orlistat, and instead contain the weight-loss drug
2970:
1097:(ACF) colon lesions than did the carcinogen plus high-fat chow without orlistat. ACF lesions are believed to be one of the earliest precursors of
121:
7477:
5790:
5215:
2422:
5880:
2555:
7608:
6050:
5855:
5556:
5390:
5078:
4982:
4042:
2748:
70:
3095:
1975:
6699:
5134:
4972:
4967:
4962:
4480:
3821:
3733:
722:
6191:
6070:
5950:
2629:
6674:
6371:
6311:
5511:
5501:
5270:
5139:
3023:
2888:
1953:
1555:
1166:
6459:
6065:
5980:
5742:
5614:
5589:
5584:
5531:
5455:
5300:
5295:
5290:
5275:
5235:
5225:
5154:
4572:
4178:
4143:
2966:
2630:"Parasite-based screening and proteome profiling reveal orlistat, an FDA-approved drug, as a potential anti Trypanosoma brucei agent"
1314:
1585:
6121:
5639:
5634:
5546:
5536:
5516:
5480:
5465:
5460:
5435:
5260:
5255:
5124:
5058:
5053:
5048:
5002:
4997:
4992:
4667:
4035:
3729:
2846:
1650:
Barbier P, Schneider F (1987). "Syntheses of tetrahydrolipstatin and absolute configuration of tetrahydrolipstatin and lipstatin".
6945:
2770:
7470:
5629:
5624:
5619:
5609:
5604:
5599:
5594:
5450:
5445:
1815:
1443:
1517:
1484:
1413:
1383:
3266:
2579:"Activity-based proteome profiling of potential cellular targets of Orlistat--an FDA-approved drug with anti-tumor activities"
5672:
5541:
5415:
3993:
2691:
2218:"Weight control and risk factor reduction in obese subjects treated for 2 years with orlistat: a randomized controlled trial"
1289:
Alli became available in the U.S. in June 2007. It is sold as 60 mg capsules—half the dosage of prescription orlistat.
2718:
1358:. The concentration of sibutramine in these counterfeit products is at least twice the amount recommended for weight loss.
1313:
U.S. patent protection for
Xenical, originally to end on 18 June 2004, was extended by five years (until 2009) by the U.S.
2133:"Orlistat and the risk of acute liver injury: self controlled case series study in UK Clinical Practice Research Datalink"
7613:
7087:
6860:
2789:
814:
2814:
5352:
7484:
3259:
742:
151:
773:
138:
7491:
5824:
4010:
6599:
838:. However, due to its relative simplicity and stability, orlistat was chosen over lipstatin for development as an
7508:
7417:
3679:
380:
236:
102:
7463:
6281:
5715:
1136:; the two drugs should therefore not be administered concomitantly. Orlistat can also impair absorption of the
467:
6825:
3000:
6791:
5762:
4942:
4537:
4213:
4123:
3056:
2850:
2065:
2062:"FDA Drug Safety Communication: Completed safety review of Xenical/Alli (orlistat) and severe liver injury"
1679:
1351:
1274:
1032:
637:
518:
2914:
7598:
7593:
7005:
6326:
6020:
5813:
5199:
5182:
4860:
4509:
4086:
598:
587:
2959:
2938:
7603:
7558:
5331:
3737:
6101:
6096:
2414:
7182:
5347:
3741:
1900:
Siebenhofer A, Winterholer S, Jeitler K, Horvath K, Berghold A, Krenn C, Semlitsch T (January 2021).
1298:
116:
6584:
6131:
5970:
2547:
7519:
7412:
7186:
7069:
6965:
6955:
6855:
6709:
6624:
5710:
4987:
4542:
4223:
3833:
3804:
3604:
2216:
Davidson MH, Hauptman J, DiGirolamo M, Foreyt JP, Halsted CH, Heber D, et al. (January 1999).
1128:(also known as "cyclosporin" or "cyclosporine", trade names Sandimmune, Gengraf, Neoral, etc.), an
910:
834:
614:
2740:
2010:, 2007 edition: "They can be an incentive to keep from eating more fat than you really intend to."
1843:
6950:
5490:
4707:
4298:
4069:
3998:
3844:
3282:
3091:
3061:
839:
192:
52:
3033:
7236:
7025:
6995:
6271:
5900:
5365:
5230:
4752:
4532:
4485:
4118:
3470:
1214:
1129:
1016:
of 15 grams per meal. The manual for Alli makes it clear that orlistat treatment involves
798:. Its primary function is preventing the absorption of fats from the human diet by acting as a
342:
326:
2773:(Press release). Australian Therapeutic Goods Administration. 22 February 2007. Archived from
567:
7513:
6940:
5769:
5017:
4108:
4075:
2329:
Takayama T, Katsuki S, Takahashi Y, Ohi M, Nojiri S, Sakamaki S, et al. (October 1998).
1322:
1246:
1090:
1078:
1000:
882:
878:
866:
507:
458:
288:
6116:
6106:
2880:
1949:
1547:
6865:
6454:
6426:
6416:
6035:
5022:
4952:
4885:
4880:
4855:
4747:
4323:
4058:
3574:
3028:
1758:
Gillies CL, Abrams KR, Lambert PC, Cooper NJ, Sutton AJ, Hsu RT, Khunti K (February 2007).
1137:
1133:
1110:
527:
422:
349:
6111:
1982:
8:
7623:
6910:
6256:
6156:
6080:
5782:
4218:
4208:
3854:
3640:
3519:
3491:
3321:
2854:
2819:
1577:
1182:
1170:
1094:
1071:
1039:
413:
199:
7177:
6450:
3240:
641:
618:
7588:
6729:
6484:
6285:
5816:
5188:
5149:
5012:
4778:
4547:
4061:
3939:
3585:
3514:
3401:
2774:
2523:
2498:
2479:
2396:
2189:
2157:
2132:
1926:
1901:
1784:
1759:
1732:
1707:
1632:
1620:
1230:
1012:
988:
923:
275:
166:
3251:
2911:"GlaxoSmithKline receives European Commission approval to market alli (orlistat 60mg)"
7618:
7269:
6818:
6434:
6141:
3913:
3391:
3386:
3220:
3190:
3140:
2687:
2680:
2649:
2598:
2528:
2471:
2444:
2388:
2352:
2311:
2275:
2239:
2162:
2108:
2043:
1931:
1807:
1789:
1737:
1677:
Pommier A, Pons M, Kocienski P (1995). "The first total synthesis of (−)-lipstatin".
1624:
1435:
1405:
1375:
826:
799:
263:
94:
6960:
2578:
2400:
2038:
2021:
1636:
806:
intake. It is intended for use in conjunction with a healthcare provider-supervised
447:
7543:
7368:
7256:
6719:
6439:
6321:
6251:
6136:
6126:
6040:
5890:
5320:
5114:
3441:
3366:
3212:
3182:
3161:
3152:
Hanessian S, Tehim A, Chen P (1993). "Total synthesis of (−)-tetrahydrolipstatin".
3132:
2641:
2590:
2518:
2510:
2483:
2463:
2380:
2342:
2303:
2267:
2229:
2152:
2144:
2104:
2100:
2033:
1921:
1917:
1913:
1779:
1771:
1727:
1723:
1719:
1688:
1659:
1616:
1017:
939:
654:
308:
219:
4027:
1147:(MHRA) has suggested the possibility that orlistat could reduce the absorption of
1020:, encouraging the user to associate eating fat with unpleasant treatment effects.
7572:
7396:
7358:
7353:
7020:
6875:
6396:
6291:
6171:
3650:
3625:
3620:
3580:
3456:
3451:
3313:
2942:
2714:
2307:
1279:
1085:
959:
859:
822:
336:
316:
6935:
6930:
6925:
2710:
2514:
2347:
2330:
1775:
80:
39:
7432:
7378:
7343:
6744:
6664:
6534:
6391:
6246:
6211:
5870:
5677:
5662:
4832:
4732:
4318:
4128:
4004:
3630:
3406:
1326:
1283:
1148:
915:
906:
886:
855:
850:
2628:
Yang PY, Wang M, Liu K, Ngai MH, Sheriff O, Lear MJ, et al. (July 2012).
7582:
7427:
7348:
7015:
7010:
6915:
6684:
6559:
6444:
6406:
6301:
6266:
6201:
6000:
5960:
5860:
5667:
5440:
4957:
4865:
4612:
4389:
4354:
4278:
4233:
3959:
3790:
3635:
3476:
3351:
2384:
1663:
1198:
1060:
969:
946:
630:
2271:
1038:
An analysis of over 900 orlistat users in
Ontario showed that their rate of
7437:
7422:
7373:
7142:
6811:
6769:
6739:
6714:
6669:
6614:
6609:
6594:
6589:
6579:
6574:
6499:
6401:
6381:
6366:
6361:
6356:
6341:
6236:
6226:
6055:
5995:
5930:
5925:
5920:
5915:
5895:
5885:
5687:
5395:
5043:
4415:
4333:
3829:
3785:
3655:
3600:
3595:
3481:
3416:
3346:
3331:
3308:
3290:
3224:
3216:
3194:
2653:
2645:
2602:
2532:
2475:
2392:
2315:
2279:
2234:
2217:
2166:
2112:
2047:
1935:
1793:
1741:
1098:
1025:
890:
214:
3144:
2356:
2243:
1628:
1406:"Beacita 120mg Capsules, hard - Summary of Product Characteristics (SmPC)"
1376:"Xenical 120 mg hard capsules - Summary of Product Characteristics (SmPC)"
1317:. The extension was granted on 20 July 2002, and expired on 18 June 2009.
7386:
7363:
7035:
6754:
6724:
6704:
6654:
6529:
6524:
6509:
6479:
6306:
6261:
6221:
6216:
6166:
6161:
6146:
5985:
5945:
5850:
5720:
5425:
5375:
5370:
5265:
5240:
5164:
5159:
5073:
5038:
4875:
4793:
4762:
4717:
4637:
4602:
4495:
4435:
4430:
4410:
4364:
4313:
4183:
4138:
3949:
3885:
3880:
3810:
3800:
3795:
3780:
3769:
3764:
3694:
3665:
3660:
3590:
3560:
3529:
3504:
3466:
3421:
3381:
3371:
3341:
3336:
2180:
1355:
1125:
1074:
1004:
955:
881:. Over-the-counter approval was controversial in the United States, with
874:
846:
88:
22:
3165:
3136:
1902:"Long-term effects of weight-reducing drugs in people with hypertension"
1692:
1237:
Orlistat prevents approximately 30% of dietary fat from being absorbed.
487:
404:)-3-Hexyl-4-oxooxetan-2-yl)tridecan-2-yl) 2-formamido-4-methylpentanoate
7442:
7391:
7299:
7251:
7065:
7055:
7050:
7040:
6920:
6734:
6694:
6639:
6629:
6569:
6554:
6539:
6519:
6494:
6489:
6469:
6464:
6421:
6411:
6376:
6351:
6331:
6296:
6275:
6231:
6206:
5990:
5955:
5940:
5935:
5904:
5865:
5845:
5410:
5405:
5250:
5245:
5198:
5129:
5119:
5068:
4870:
4818:
4813:
4808:
4632:
4607:
4597:
4475:
4440:
4425:
4379:
4374:
4369:
4188:
4173:
3974:
3964:
3954:
3934:
3895:
3875:
3859:
3759:
3754:
3719:
3714:
3709:
3704:
3610:
3565:
3524:
3431:
3326:
1210:
1206:
1205:. When lipase activity is blocked, triglycerides from the diet are not
1178:
1174:
1140:
905:. The amount of weight loss achieved with orlistat varies. In one-year
791:
684:
498:
3186:
2594:
2448:
2331:"Aberrant crypt foci of the colon as precursors of adenoma and cancer"
2148:
1436:"alli 60 mg hard capsules - Summary of Product Characteristics (SmPC)"
1050:
decision to begin treatment rather than any causal effect of the drug.
7525:
7309:
7289:
7246:
7241:
7221:
7216:
7157:
7127:
7107:
7060:
7045:
7030:
6659:
6649:
6644:
6634:
6619:
6604:
6549:
6504:
6474:
6336:
6316:
6241:
6181:
6176:
6045:
5975:
5965:
5910:
5380:
4977:
4742:
4722:
4687:
4682:
4677:
4627:
4567:
4562:
4557:
4465:
4460:
4450:
4420:
4283:
4273:
4203:
4198:
3944:
3929:
3905:
3774:
3699:
3689:
3645:
3570:
3534:
3509:
3499:
3446:
3396:
3361:
3299:
3286:
2955:
2467:
2415:"Orlistat: theoretical interaction with antiretroviral HIV medicines"
2131:
Douglas IJ, Langham J, Bhaskaran K, Brauer R, Smeeth L (April 2013).
1848:
1202:
1116:
and other fat-soluble nutrients is inhibited by the use of orlistat.
984:
965:
818:
433:
362:
74:
30:
1899:
1217:
after an oral dose. The primary route of elimination is through the
865:
Benefits aside, however, orlistat is noted for its gastrointestinal
7294:
7284:
7279:
7274:
7231:
7167:
7162:
7137:
7117:
7102:
7097:
6564:
6514:
6386:
6346:
6196:
6186:
6060:
4798:
4712:
4692:
4647:
4622:
4384:
4338:
4308:
4288:
4238:
4228:
3969:
3615:
3555:
3461:
3426:
3411:
3376:
1976:"FDA Approves alli (orlistat 60 mg capsules) Over-The-Counter"
1066:
974:
927:
830:
547:
478:
133:
2577:
Yang PY, Liu K, Ngai MH, Lear MJ, Wenk MR, Yao SQ (January 2010).
1301:
granted approval for the sale of orlistat without a prescription.
707:
7264:
7226:
7208:
7172:
7132:
7112:
7092:
6834:
6774:
6759:
6689:
6151:
5875:
5649:
5430:
4906:
4803:
4788:
4727:
4702:
4672:
4662:
4657:
4652:
4592:
4587:
4582:
4577:
4445:
4405:
4359:
4293:
4263:
4258:
4253:
4248:
4168:
4163:
4158:
4153:
4148:
3749:
3538:
3356:
2913:(Press release). GlaxoSmithKline. 21 January 2009. Archived from
1190:
1113:
978:
902:
807:
803:
795:
5571:
3121:
2994:"Drug Patent Expirations in June 2009". DrugPatentWatch.com, in
2548:"Orlistat & Xenical: Do Weight Loss Pills Work? | e-Surgery"
2499:"Orlistat, a new lipase inhibitor for the management of obesity"
2215:
1162:
7304:
7152:
7147:
7122:
6890:
6870:
5650:
5561:
5526:
5521:
5470:
5400:
5314:
5285:
5280:
5098:
5063:
5007:
4911:
4890:
4783:
4737:
4697:
4642:
4552:
4470:
4455:
4328:
4303:
4268:
4243:
4133:
1194:
1008:
578:
2960:"Certificate Extending Patent Term Under 35 U.S.C. § 156"
5572:
5360:
5220:
4926:
4617:
4490:
4193:
3979:
2815:"Panel Supports Offering Diet Pill Orlistat Over the Counter"
2292:
2130:
1981:(Press release). PR Newswire. 7 February 2007. Archived from
1218:
698:
558:
120:
1226:
inhibit the thioesterase domain of fatty acid synthase (FAS)
603:
7314:
5506:
5385:
3436:
2935:
2328:
919:
538:
5812:
2453:
2185:"Obesity Drug Can Lead to Modest Weight Loss, Study Finds"
1757:
1257:
In Australia and New Zealand, orlistat is available as a "
1151:
5825:
1261:". In 2007, the Committee decided to keep orlistat as a
3281:
2369:
889:
repeatedly opposing it on safety and efficacy grounds.
6803:
5097:
4833:
2090:
1708:"Long-term pharmacotherapy for obesity and overweight"
1011:
due to unabsorbed fats reaching the large intestine),
1003:
of the drug are gastrointestinal-related, and include
7556:
4925:
4838:
2026:
Arquivos Brasileiros de Endocrinologia e Metabologia
1676:
1189:
Orlistat works by inhibiting gastric and pancreatic
5200:
4510:
4087:
4057:
2419:
Medicines and Healthcare products Regulatory Agency
1479:
1477:
1475:
1473:
1471:
1469:
1467:
1465:
1463:
1461:
1145:
Medicines and Healthcare products Regulatory Agency
466:
5332:
3151:
2679:
2256:
2013:
1606:
2496:
1706:Padwal R, Li SK, Lau DC (2004). Padwal RS (ed.).
1292:
7580:
2847:"FDA Approves Orlistat for Over-the-Counter Use"
2790:"F.D.A. Approves Fat-Blocking Anti-Obesity Drug"
2126:
2124:
2122:
1649:
1512:
1510:
1458:
1286:opposed over-the-counter approval for orlistat.
446:
7478:GlaxoSmithKline Services Unlimited v Commission
3201:
3172:
2627:
2576:
2250:
1968:
1814:. Therapeutic Goods Administration. June 2017.
1185:; carbon = grey, oxygen = red, nitrogen = blue)
1081:in breast cancer cells and block their growth.
421:
2881:"Weight-Loss Drug to Be Sold Over the Counter"
2019:
1670:
730:O=C(O(C1OC(=O)1CCCCCC)CCCCCCCCCCC)(NC=O)CC(C)C
150:
6819:
5798:
4043:
3267:
3054:
2781:
2497:Heck AM, Yanovski JA, Calis KA (March 2000).
2286:
2119:
1507:
5746:(FAAH-like anandamide transporter inhibitor)
5734:(directly potentiates activity of 2-AG at CB
3092:"Fake Alli diet pills can pose health risks"
3057:"Glaxo Sells Bulk of Over-the-Counter Drugs"
2945:, directory of drugs approved in Switzerland
2437:
1643:
1252:
137:
6081:
2999:. Biotech Blog. 1 June 2009. Archived from
1906:The Cochrane Database of Systematic Reviews
1712:The Cochrane Database of Systematic Reviews
1705:
1540:
1398:
1368:
845:The effectiveness of orlistat in promoting
6826:
6812:
6132:Allopregnanedione (5α-dihydroprogesterone)
5805:
5791:
4050:
4036:
3274:
3260:
1873:
1871:
1753:
1751:
640:
617:
506:
3021:
2967:United States Patent and Trademark Office
2522:
2456:Nature Structural & Molecular Biology
2346:
2233:
2156:
2037:
1925:
1844:"FDA OKs First Nonprescription Diet Pill"
1783:
1731:
1093:produced significantly higher numbers of
849:is definite but modest. Pooled data from
526:
5830:Tooltip Constitutive androstane receptor
3175:Journal of the American Chemical Society
2787:
2583:Journal of the American Chemical Society
1570:
1428:
1161:
1042:was more than triple that of non-users.
7471:Christopher v. SmithKline Beecham Corp.
5107:
1868:
1748:
1345:
1308:
1273:Orlistat was initially approved by the
613:
486:
93:
7581:
6585:Pregnanedione (5β-dihydroprogesterone)
5971:Pregnanedione (5β-dihydroprogesterone)
2997:"Drug Patent Expirations in June 2009"
2976:from the original on 29 September 2006
2874:
2872:
2853:(FDA). 7 February 2007. Archived from
2705:
2703:
2545:
2179:
2022:"Pharmacological treatment of obesity"
1841:
1837:
1835:
1833:
1699:
1332:
1157:
901:Orlistat is used for the treatment of
631:
295:
269:
111:
6946:Recherche et Industrie Thérapeutiques
6807:
5786:
4031:
3255:
2954:
2763:
2682:2006 Physicians' Desk Reference (PDR)
2425:from the original on 29 November 2014
1879:"Orlistat 120mg capsule blister pack"
1818:from the original on 13 December 2020
1528:from the original on 30 November 2021
1124:Orlistat may reduce plasma levels of
586:
566:
282:
145:
128:
79:
7609:Drugs developed by Hoffmann-La Roche
5441:Redafamdastat (JZP-150, PF-04457845)
3247:. U.S. National Library of Medicine.
3098:from the original on 25 January 2010
2891:from the original on 25 October 2021
2878:
2827:from the original on 25 October 2021
2751:from the original on 5 December 2020
2721:from the original on 23 January 2009
2609:from the original on 25 October 2021
2558:from the original on 16 January 2021
2020:Mancini MC, Halpern A (April 2006).
1956:from the original on 13 October 2017
1856:from the original on 25 October 2021
1588:from the original on 23 January 2022
1446:from the original on 18 January 2022
1245:Orlistat is available both with and
1064:had them. There is evidence from an
933:
858:and appears to prevent the onset of
218:
6861:GlaxoSmithKline Pharmaceuticals Ltd
5205:Tooltip Endocannabinoid transporter
4518:Tooltip Cannabinoid receptor type 2
4095:Tooltip Cannabinoid receptor type 1
3069:from the original on 27 August 2016
2869:
2700:
2672:
2335:The New England Journal of Medicine
2197:from the original on 13 August 2019
1830:
1007:(oily, loose stools with excessive
546:
437:
13:
5337:Tooltip Fatty acid amide hydrolase
3114:
2807:
2788:Stolberg, Sheryl (27 April 1999).
2711:"Chemists to provide obesity pill"
2072:from the original on 27 April 2022
1621:10.1002/j.1552-4604.1995.tb04034.x
1558:from the original on 15 April 2021
14:
7635:
7485:United States v. Glaxo Group Ltd.
3233:
2851:U.S. Food and Drug Administration
2823:. 24 January 2006. pp. A02.
1495:from the original on 17 July 2022
1386:from the original on 8 March 2022
1352:U.S. Food and Drug Administration
1275:U.S. Food and Drug Administration
1033:U.S. Food and Drug Administration
245:
177:
7566:
7539:
7538:
7492:United States v. GlaxoSmithKline
3154:The Journal of Organic Chemistry
2660:from the original on 9 June 2020
2373:Journal of Clinical Pharmacology
1609:Journal of Clinical Pharmacology
1416:from the original on 1 July 2022
1268:
918:(mean reductions of 2.5 and 1.9
671:
665:
38:
29:
7509:Drug Industry Documents Archive
3084:
3055:Jeanne Whalen (20 April 2012).
3048:
3015:
2988:
2948:
2929:
2903:
2839:
2733:
2621:
2570:
2539:
2490:
2407:
2363:
2322:
2209:
2173:
2084:
2054:
2039:10.1590/S0004-27302006000200024
2000:
1942:
1893:
1812:Federal Register of Legislation
1800:
1240:
1119:
994:
987:, impaired liver function, and
896:
755:Key:AHLBNYSZXLDEJQ-FWEHEUNISA-N
7464:Canada v. GlaxoSmithKline Inc.
6137:Allopregnanolone (brexanolone)
5683:Orlistat (tetrahydrolipstatin)
3125:Journal of Medicinal Chemistry
2105:10.1001/archinternmed.2011.103
1918:10.1002/14651858.CD007654.pub5
1724:10.1002/14651858.CD004094.pub2
1600:
1293:European Union and Switzerland
1181:= red) inhibited by orlistat (
1104:
1059:Despite a higher incidence of
930:blood pressure respectively).
674:
659:
258:
16:Drug designed to treat obesity
1:
6792:Receptor/signaling modulators
6750:Tropanyl 3,5-dimethulbenzoate
6600:Pregnenolone 16α-carbonitrile
5763:Receptor/signaling modulators
4234:Gallocatechol (gallocatechin)
3205:Chemistry: A European Journal
2634:Chemistry: A European Journal
2093:Archives of Internal Medicine
1842:Schmid RE (9 February 2007).
1361:
1173:thioesterase (rainbow color,
1084:Fecal fat excretion promotes
983:Use caution with: obstructed
300: OTC / Rx-only
3022:Devarajan U (1 March 2009).
2308:10.1016/j.canlet.2005.09.011
2066:Food and Drug Administration
1808:"POISONS STANDARD JUNE 2017"
1680:Journal of Organic Chemistry
1054:
951:Hypersensitivity to orlistat
786:, sold under the brand name
7:
6327:Dodecylbenzenesulfonic acid
6086:Tooltip Pregnane X receptor
5814:Xenobiotic-sensing receptor
5772:(cannabinoids by structure)
5426:Paracetamol (acetaminophen)
5266:Paracetamol (acetaminophen)
2515:10.1592/phco.20.4.270.34882
2348:10.1056/NEJM199810293391803
1776:10.1136/bmj.39063.689375.55
1485:"Xenical- orlistat capsule"
1315:Patent and Trademark Office
1224:Orlistat was also found to
1132:frequently used to prevent
10:
7640:
7614:Drugs developed by GSK plc
2879:Saul S (7 February 2007).
1167:Crystallographic structure
869:(sometimes referred to as
649:Chemical and physical data
7534:
7501:
7455:
7405:
7334:
7327:
7201:
7080:
6988:
6981:
6974:
6966:Smith, Kline & French
6901:
6885:
6848:
6841:
6783:
6079:
5823:
5754:
5700:
5648:
5570:
5489:
5348:4-Nonylphenylboronic acid
5330:
5313:
5181:
5096:
5031:
4935:
4924:
4899:
4848:
4831:
4771:
4525:
4508:
4398:
4347:
4102:
4085:
4068:
3988:
3922:
3904:
3868:
3843:
3820:
3728:
3678:
3548:
3490:
3307:
3298:
2745:European Medicines Agency
1582:European Medicines Agency
1552:European Medicines Agency
1325:), Orsoten/Orsoten Slim (
1299:European Medicines Agency
1253:Australia and New Zealand
763:
738:
718:
696:
683:
653:
648:
629:
597:
577:
557:
537:
517:
497:
477:
457:
432:
412:
376:
371:
361:
348:
335:
325:
315:
307:
235:
230:
205:
191:
165:
101:
87:
69:
61:
51:
46:
37:
28:
6956:S. E. Massengill Company
6856:GlaxoSmithKline Pakistan
6710:Testosterone isocaproate
6625:Reverse triiodothyronine
5711:Phosphatidylethanolamine
4988:Lysophosphatidylinositol
4426:Falcarinol (carotatoxin)
3094:. CNN. 23 January 2010.
2936:http://www.compendium.ch
2771:"Scheduling of orlistat"
2546:Higham G (5 June 2020).
2385:10.1177/0091270003252236
1664:10.1002/hlca.19870700124
1518:"Alli- orlistat capsule"
1297:On 21 January 2009, the
1259:Pharmacist Only Medicine
835:Streptomyces toxytricini
6951:Reliant Pharmaceuticals
6833:
6102:17α-Hydroxyprogesterone
6097:17α-Hydroxypregnenolone
5421:Palmitoylisopropylamide
3245:Drug Information Portal
3062:The Wall Street Journal
2941:10 October 2021 at the
2421:(MHRA). 13 March 2014.
1337:
5366:Arachidonoyl serotonin
5231:Arachidonoyl serotonin
4633:GW-405,833 (L-768,242)
3217:10.1002/chem.201200482
2646:10.1002/chem.201200482
2235:10.1001/jama.281.3.235
1652:Helvetica Chimica Acta
1247:without a prescription
1186:
1130:immunosuppressive drug
1052:
879:without a prescription
7514:GlaxoSmithKline Prize
6941:Human Genome Sciences
5841:6,7-Dimethylesculetin
5018:Palmitoylethanolamide
4943:2-AGE (noladin ether)
4543:3,3'-Diindolylmethane
4538:2-AGE (noladin ether)
4124:2-AGE (noladin ether)
3869:Absorption inhibitors
2686:. Thomson PDR. 2006.
2272:10.1093/annonc/mdi239
2068:(FDA). 28 June 2019.
1584:. 17 September 2018.
1554:. 17 September 2018.
1350:In January 2010, the
1209:into absorbable free
1165:
1091:1,2-dimethylhydrazine
1047:
958:function (e.g. after
873:), which can include
6911:Allen & Hanburys
6866:Stiefel Laboratories
6428:Hypericum perforatum
6417:Hetacillin potassium
4953:Abnormal cannabidiol
4856:Abnormal cannabidiol
4688:Lenabasum (anabasum)
4059:Cannabinoid receptor
3029:The Deccan Chronicle
2777:on 29 December 2007.
2008:Alli Companion Guide
2006:From page 12 of the
1881:. TGA. 11 April 2000
1412:. 11 November 2020.
1346:Counterfeit products
1309:Generic formulations
1134:transplant rejection
1031:On 26 May 2010, the
808:reduced-calorie diet
291: / Rx-only
6257:Cyproterone acetate
6157:Amlodipine besylate
4553:α-Amyrin · β-Amyrin
4209:Dimethylheptylpyran
4134:α-Amyrin · β-Amyrin
3641:Phenylpropanolamine
3520:Levopropylhexedrine
3492:Adrenergic agonists
3322:4-Methylamphetamine
3166:10.1021/jo00079a022
3137:10.1021/jm00029a013
2820:The Washington Post
2717:. 21 January 2009.
2183:(20 January 1999).
1693:10.1021/jo00127a045
1524:. 9 November 2020.
1491:. 9 December 2021.
1333:Society and culture
1183:space-filling model
1171:fatty acid synthase
1158:Mechanism of action
1095:aberrant crypt foci
1072:monoclonal antibody
1040:acute kidney injury
802:, thereby reducing
790:among others, is a
65:tetrahydrolipstatin
25:
7599:Carboxylate esters
7594:Anti-obesity drugs
7418:Silas M. Burroughs
6961:SmithKline Beecham
6926:Burroughs Wellcome
6730:Thonzonium bromide
6485:Methylprednisolone
6286:prasterone sulfate
5150:Oleoylethanolamide
5084:Tetrahydromagnolol
5013:Oleoylethanolamide
4779:4-O-Methylhonokiol
4758:Tetrahydromagnolol
4713:Olorinab (APD-371)
4548:4-O-Methylhonokiol
4015:Never to phase III
3940:Desiccated thyroid
3586:Dexmethylphenidate
3283:Antiobesity agents
2917:on 27 January 2009
2885:The New York Times
2794:The New York Times
2260:Annals of Oncology
2190:The New York Times
1950:"Treating Obesity"
1231:Trypanosoma brucei
1187:
1013:fecal incontinence
989:pancreatic disease
829:isolated from the
827:pancreatic lipases
276:Pharmacy medicines
21:
7604:Lipase inhibitors
7554:
7553:
7451:
7450:
7323:
7322:
7197:
7196:
6897:
6896:
6801:
6800:
6435:Indinavir sulfate
6142:Alpha-Lipoic acid
6117:Δ-Androstenedione
6107:Δ-Androstenedione
5780:
5779:
5696:
5695:
5309:
5308:
5177:
5176:
5173:
5172:
5092:
5091:
4920:
4919:
4827:
4826:
4504:
4503:
4025:
4024:
3914:2,4-Dinitrophenol
3847:receptor agonists
3742:glucagon agonists
3674:
3673:
3392:Dimethylcathinone
3387:Dextroamphetamine
3211:(27): 8403–8413.
3187:10.1021/ja907716f
2849:(Press release).
2693:978-1-56363-527-4
2640:(27): 8403–8413.
2595:10.1021/ja907716f
2341:(18): 1277–1284.
2149:10.1136/bmj.f1936
1988:on 24 August 2007
1687:(22): 7334–7339.
1615:(11): 1103–1108.
1323:Hoffmann–La Roche
934:Contraindications
883:consumer advocacy
871:treatment effects
840:anti-obesity drug
781:
780:
709:Interactive image
599:CompTox Dashboard
299:
286:
278:) / POM
273:
261:
254:(Pharmacist only)
249:
181:
148:
131:
114:
7631:
7571:
7570:
7569:
7562:
7542:
7541:
7369:Patrick Vallance
7332:
7331:
7061:Wellbutrin/Zyban
6986:
6985:
6979:
6978:
6846:
6845:
6828:
6821:
6814:
6805:
6804:
6720:Thiamylal sodium
6455:γ-linolenic acid
6451:α-Linolenic acid
6449:Linolenic acid:
6440:Lasalocid sodium
6430:(St John's wort)
6322:Docusate calcium
6252:Cyclophosphamide
6127:Allopregnanediol
6112:Δ-Androstenediol
6087:
6083:
6041:Ethinylestradiol
5891:Cyclophosphamide
5831:
5827:
5807:
5800:
5793:
5784:
5783:
5653:
5575:
5338:
5334:
5328:
5327:
5324:
5206:
5202:
5196:
5195:
5192:
5145:N-Oleoyldopamine
5115:2-Oleoylglycerol
5105:
5104:
5101:
5023:THC (dronabinol)
4933:
4932:
4929:
4886:THC (dronabinol)
4846:
4845:
4840:
4835:
4748:THC (dronabinol)
4523:
4522:
4519:
4515:
4348:Inverse agonists
4324:THC (dronabinol)
4100:
4099:
4096:
4092:
4083:
4082:
4079:
4052:
4045:
4038:
4029:
4028:
3442:Lisdexamfetamine
3367:Chlorphentermine
3305:
3304:
3276:
3269:
3262:
3253:
3252:
3248:
3228:
3198:
3169:
3148:
3108:
3107:
3105:
3103:
3088:
3082:
3081:
3076:
3074:
3052:
3046:
3045:
3043:
3041:
3036:on 10 March 2009
3032:. Archived from
3019:
3013:
3012:
3010:
3008:
2992:
2986:
2985:
2983:
2981:
2975:
2964:
2958:(30 July 2002).
2952:
2946:
2933:
2927:
2926:
2924:
2922:
2907:
2901:
2900:
2898:
2896:
2876:
2867:
2866:
2864:
2862:
2843:
2837:
2836:
2834:
2832:
2811:
2805:
2804:
2802:
2800:
2785:
2779:
2778:
2767:
2761:
2760:
2758:
2756:
2737:
2731:
2730:
2728:
2726:
2707:
2698:
2697:
2685:
2676:
2670:
2669:
2667:
2665:
2625:
2619:
2618:
2616:
2614:
2574:
2568:
2567:
2565:
2563:
2543:
2537:
2536:
2526:
2494:
2488:
2487:
2468:10.1038/nsmb1265
2451:
2441:
2435:
2434:
2432:
2430:
2411:
2405:
2404:
2367:
2361:
2360:
2350:
2326:
2320:
2319:
2290:
2284:
2283:
2266:(8): 1253–1267.
2254:
2248:
2247:
2237:
2213:
2207:
2206:
2204:
2202:
2177:
2171:
2170:
2160:
2128:
2117:
2116:
2088:
2082:
2081:
2079:
2077:
2058:
2052:
2051:
2041:
2017:
2011:
2004:
1998:
1997:
1995:
1993:
1987:
1980:
1972:
1966:
1965:
1963:
1961:
1946:
1940:
1939:
1929:
1897:
1891:
1890:
1888:
1886:
1875:
1866:
1865:
1863:
1861:
1839:
1828:
1827:
1825:
1823:
1804:
1798:
1797:
1787:
1755:
1746:
1745:
1735:
1703:
1697:
1696:
1674:
1668:
1667:
1647:
1641:
1640:
1604:
1598:
1597:
1595:
1593:
1574:
1568:
1567:
1565:
1563:
1544:
1538:
1537:
1535:
1533:
1514:
1505:
1504:
1502:
1500:
1481:
1456:
1455:
1453:
1451:
1442:. 11 June 2021.
1432:
1426:
1425:
1423:
1421:
1402:
1396:
1395:
1393:
1391:
1372:
1197:that break down
1018:aversion therapy
813:Orlistat is the
800:lipase inhibitor
777:
776:
769:
711:
691:
676:
673:
667:
661:
644:
633:
622:
621:
607:
605:
590:
570:
550:
530:
510:
490:
470:
450:
440:
439:
425:
353:
297:
294:
284:
281:
271:
268:
260:
257:
247:
244:
222:
179:
176:
158:
147:
144:
141:
130:
127:
124:
113:
110:
97:
83:
42:
33:
26:
24:
20:
7639:
7638:
7634:
7633:
7632:
7630:
7629:
7628:
7579:
7578:
7577:
7567:
7565:
7557:
7555:
7550:
7530:
7497:
7447:
7401:
7397:Laurie Glimcher
7364:Manvinder Banga
7359:Roy M. Anderson
7354:Simon Dingemans
7336:
7319:
7193:
7076:
6970:
6903:
6893:
6881:
6876:ViiV Healthcare
6837:
6832:
6802:
6797:
6779:
6680:Suberoylanilide
6397:Fluorometholone
6292:Dibunate sodium
6172:Aurothioglucose
6085:
6075:
6011:3,17β-Estradiol
5829:
5819:
5811:
5781:
5776:
5750:
5737:
5692:
5644:
5566:
5485:
5356:
5336:
5318:
5317:
5305:
5204:
5186:
5185:
5169:
5088:
5027:
4916:
4895:
4836:
4823:
4767:
4517:
4514:
4500:
4394:
4343:
4107:
4104:
4094:
4091:
4073:
4072:
4064:
4056:
4026:
4021:
4020:
4005:Clinical trials
3984:
3918:
3900:
3864:
3846:
3839:
3816:
3740:
3724:
3681:
3670:
3651:Propylhexedrine
3626:Phendimetrazine
3621:Methylphenidate
3581:Dexfenfluramine
3544:
3486:
3457:Norfenfluramine
3452:Methamphetamine
3314:phenethylamines
3312:
3294:
3280:
3239:
3236:
3231:
3117:
3115:Further reading
3112:
3111:
3101:
3099:
3090:
3089:
3085:
3072:
3070:
3053:
3049:
3039:
3037:
3020:
3016:
3006:
3004:
2995:
2993:
2989:
2979:
2977:
2973:
2962:
2953:
2949:
2943:Wayback Machine
2934:
2930:
2920:
2918:
2909:
2908:
2904:
2894:
2892:
2877:
2870:
2860:
2858:
2845:
2844:
2840:
2830:
2828:
2813:
2812:
2808:
2798:
2796:
2786:
2782:
2769:
2768:
2764:
2754:
2752:
2739:
2738:
2734:
2724:
2722:
2715:BBC News Online
2709:
2708:
2701:
2694:
2678:
2677:
2673:
2663:
2661:
2626:
2622:
2612:
2610:
2575:
2571:
2561:
2559:
2544:
2540:
2503:Pharmacotherapy
2495:
2491:
2443:
2442:
2438:
2428:
2426:
2413:
2412:
2408:
2368:
2364:
2327:
2323:
2291:
2287:
2255:
2251:
2214:
2210:
2200:
2198:
2178:
2174:
2129:
2120:
2089:
2085:
2075:
2073:
2060:
2059:
2055:
2018:
2014:
2005:
2001:
1991:
1989:
1985:
1978:
1974:
1973:
1969:
1959:
1957:
1948:
1947:
1943:
1912:(1): CD007654.
1898:
1894:
1884:
1882:
1877:
1876:
1869:
1859:
1857:
1840:
1831:
1821:
1819:
1806:
1805:
1801:
1756:
1749:
1718:(3): CD004094.
1704:
1700:
1675:
1671:
1648:
1644:
1605:
1601:
1591:
1589:
1576:
1575:
1571:
1561:
1559:
1546:
1545:
1541:
1531:
1529:
1516:
1515:
1508:
1498:
1496:
1483:
1482:
1459:
1449:
1447:
1434:
1433:
1429:
1419:
1417:
1404:
1403:
1399:
1389:
1387:
1382:. 18 May 2017.
1374:
1373:
1369:
1364:
1348:
1340:
1335:
1311:
1295:
1280:GlaxoSmithKline
1271:
1263:Schedule 3 drug
1255:
1243:
1160:
1122:
1107:
1057:
997:
960:cholecystectomy
940:contraindicated
936:
907:clinical trials
899:
860:type 2 diabetes
851:clinical trials
772:
770:
767:(what is this?)
764:
759:
756:
751:
746:
745:
734:
731:
726:
725:
714:
689:
679:
670:
664:
625:
601:
593:
573:
553:
533:
513:
493:
473:
453:
436:
428:
408:
405:
384:
383:
351:
327:Protein binding
317:Bioavailability
309:Pharmacokinetic
303:
226:
194:
187:
168:
161:
17:
12:
11:
5:
7637:
7627:
7626:
7621:
7616:
7611:
7606:
7601:
7596:
7591:
7576:
7575:
7552:
7551:
7549:
7548:
7535:
7532:
7531:
7529:
7528:
7523:
7516:
7511:
7505:
7503:
7499:
7498:
7496:
7495:
7488:
7481:
7474:
7467:
7459:
7457:
7453:
7452:
7449:
7448:
7446:
7445:
7440:
7435:
7433:Henry Wellcome
7430:
7425:
7420:
7415:
7413:Thomas Beecham
7409:
7407:
7403:
7402:
7400:
7399:
7394:
7389:
7384:
7381:
7379:Lynn Elsenhans
7376:
7371:
7366:
7361:
7356:
7351:
7346:
7344:Philip Hampton
7340:
7338:
7329:
7325:
7324:
7321:
7320:
7318:
7317:
7312:
7307:
7302:
7297:
7292:
7287:
7282:
7277:
7272:
7270:Goody's Powder
7267:
7262:
7259:
7254:
7249:
7244:
7239:
7234:
7229:
7224:
7219:
7214:
7211:
7205:
7203:
7199:
7198:
7195:
7194:
7192:
7191:
7180:
7175:
7170:
7165:
7160:
7155:
7150:
7145:
7140:
7135:
7130:
7125:
7120:
7115:
7110:
7105:
7100:
7095:
7090:
7084:
7082:
7078:
7077:
7075:
7074:
7063:
7058:
7053:
7048:
7043:
7038:
7033:
7028:
7023:
7018:
7013:
7008:
7003:
6998:
6992:
6990:
6983:
6976:
6972:
6971:
6969:
6968:
6963:
6958:
6953:
6948:
6943:
6938:
6936:Glaxo Wellcome
6933:
6928:
6923:
6918:
6913:
6907:
6905:
6899:
6898:
6895:
6894:
6889:
6887:
6883:
6882:
6880:
6879:
6873:
6868:
6863:
6858:
6852:
6850:
6843:
6839:
6838:
6831:
6830:
6823:
6816:
6808:
6799:
6798:
6796:
6795:
6788:
6784:
6781:
6780:
6778:
6777:
6772:
6763:
6762:
6757:
6752:
6747:
6745:Troleandomycin
6742:
6737:
6732:
6727:
6722:
6717:
6712:
6707:
6702:
6697:
6692:
6687:
6682:
6677:
6672:
6667:
6665:Spironolactone
6662:
6657:
6652:
6647:
6642:
6637:
6632:
6627:
6622:
6617:
6612:
6607:
6602:
6597:
6592:
6587:
6582:
6577:
6572:
6567:
6562:
6557:
6552:
6547:
6542:
6537:
6535:Norelgestromin
6532:
6527:
6522:
6517:
6512:
6507:
6502:
6497:
6492:
6487:
6482:
6477:
6472:
6467:
6462:
6457:
6447:
6442:
6437:
6432:
6424:
6419:
6414:
6409:
6404:
6399:
6394:
6392:Flucloxacillin
6389:
6384:
6379:
6374:
6369:
6364:
6359:
6354:
6349:
6344:
6339:
6334:
6329:
6324:
6319:
6314:
6309:
6304:
6299:
6294:
6289:
6279:
6269:
6264:
6259:
6254:
6249:
6247:Corticosterone
6244:
6239:
6234:
6229:
6224:
6219:
6214:
6212:Chlorpromazine
6209:
6204:
6199:
6194:
6189:
6184:
6179:
6174:
6169:
6164:
6159:
6154:
6149:
6144:
6139:
6134:
6129:
6124:
6119:
6114:
6109:
6104:
6099:
6090:
6088:
6077:
6076:
6074:
6073:
6068:
6063:
6058:
6053:
6048:
6043:
6038:
6033:
6031:17-Androstanol
6028:
6026:3β-Androstanol
6023:
6021:3α-Androstenol
6018:
6016:3α-Androstanol
6013:
6004:
6003:
5998:
5993:
5988:
5983:
5978:
5973:
5968:
5963:
5958:
5953:
5948:
5943:
5938:
5933:
5928:
5923:
5918:
5913:
5908:
5898:
5893:
5888:
5883:
5878:
5873:
5871:Chlorpromazine
5868:
5863:
5858:
5853:
5848:
5843:
5834:
5832:
5821:
5820:
5810:
5809:
5802:
5795:
5787:
5778:
5777:
5775:
5774:
5766:
5759:
5755:
5752:
5751:
5749:
5748:
5740:
5735:
5724:
5723:
5721:Diacylglycerol
5718:
5713:
5704:
5702:
5698:
5697:
5694:
5693:
5691:
5690:
5685:
5680:
5678:Oleanolic acid
5675:
5670:
5665:
5663:Betulinic acid
5656:
5654:
5646:
5645:
5643:
5642:
5637:
5632:
5627:
5622:
5617:
5612:
5607:
5602:
5597:
5592:
5587:
5578:
5576:
5568:
5567:
5565:
5564:
5559:
5554:
5549:
5544:
5539:
5534:
5529:
5524:
5519:
5514:
5509:
5504:
5495:
5493:
5487:
5486:
5484:
5483:
5474:
5473:
5468:
5463:
5458:
5453:
5448:
5443:
5438:
5433:
5428:
5423:
5418:
5413:
5408:
5403:
5398:
5393:
5388:
5383:
5378:
5373:
5368:
5363:
5358:
5354:
5350:
5341:
5339:
5325:
5311:
5310:
5307:
5306:
5304:
5303:
5298:
5293:
5288:
5283:
5278:
5273:
5268:
5263:
5258:
5253:
5248:
5243:
5238:
5233:
5228:
5223:
5218:
5209:
5207:
5193:
5179:
5178:
5175:
5174:
5171:
5170:
5168:
5167:
5162:
5157:
5152:
5147:
5142:
5137:
5132:
5127:
5122:
5117:
5111:
5109:
5102:
5094:
5093:
5090:
5089:
5087:
5086:
5081:
5076:
5071:
5066:
5061:
5056:
5051:
5046:
5041:
5035:
5033:
5029:
5028:
5026:
5025:
5020:
5015:
5010:
5005:
5000:
4995:
4990:
4985:
4980:
4975:
4970:
4965:
4960:
4955:
4950:
4945:
4939:
4937:
4930:
4922:
4921:
4918:
4917:
4915:
4914:
4909:
4903:
4901:
4897:
4896:
4894:
4893:
4888:
4883:
4878:
4873:
4868:
4863:
4858:
4852:
4850:
4843:
4829:
4828:
4825:
4824:
4822:
4821:
4816:
4811:
4806:
4801:
4796:
4791:
4786:
4781:
4775:
4773:
4769:
4768:
4766:
4765:
4760:
4755:
4750:
4745:
4740:
4735:
4733:Serinolamide A
4730:
4725:
4720:
4715:
4710:
4705:
4700:
4695:
4690:
4685:
4680:
4675:
4670:
4665:
4660:
4655:
4650:
4645:
4640:
4635:
4630:
4625:
4620:
4615:
4610:
4605:
4600:
4595:
4590:
4585:
4580:
4575:
4570:
4565:
4560:
4555:
4550:
4545:
4540:
4535:
4529:
4527:
4520:
4512:
4506:
4505:
4502:
4501:
4499:
4498:
4493:
4488:
4483:
4478:
4473:
4468:
4463:
4458:
4453:
4448:
4443:
4438:
4433:
4428:
4423:
4418:
4413:
4408:
4402:
4400:
4396:
4395:
4393:
4392:
4387:
4382:
4377:
4372:
4367:
4362:
4357:
4351:
4349:
4345:
4344:
4342:
4341:
4336:
4331:
4326:
4321:
4319:Serinolamide A
4316:
4311:
4306:
4301:
4296:
4291:
4286:
4281:
4276:
4271:
4266:
4261:
4256:
4251:
4246:
4241:
4236:
4231:
4226:
4221:
4216:
4211:
4206:
4201:
4196:
4191:
4186:
4181:
4176:
4171:
4166:
4161:
4156:
4151:
4146:
4141:
4136:
4131:
4129:11-Hydroxy-THC
4126:
4121:
4115:
4113:
4097:
4089:
4080:
4066:
4065:
4055:
4054:
4047:
4040:
4032:
4023:
4022:
4019:
4018:
4017:
4016:
4013:
4002:
3996:
3990:
3989:
3986:
3985:
3983:
3982:
3977:
3972:
3967:
3962:
3957:
3952:
3947:
3942:
3937:
3932:
3926:
3924:
3920:
3919:
3917:
3916:
3910:
3908:
3902:
3901:
3899:
3898:
3893:
3888:
3883:
3878:
3872:
3870:
3866:
3865:
3863:
3862:
3857:
3851:
3849:
3841:
3840:
3838:
3837:
3826:
3824:
3818:
3817:
3815:
3814:
3808:
3798:
3793:
3788:
3783:
3778:
3772:
3767:
3762:
3757:
3752:
3746:
3744:
3726:
3725:
3723:
3722:
3717:
3712:
3707:
3702:
3697:
3692:
3686:
3684:
3676:
3675:
3672:
3671:
3669:
3668:
3663:
3658:
3653:
3648:
3643:
3638:
3633:
3631:Phenethylamine
3628:
3623:
3618:
3613:
3608:
3598:
3593:
3588:
3583:
3578:
3568:
3563:
3558:
3552:
3550:
3546:
3545:
3543:
3542:
3532:
3527:
3522:
3517:
3512:
3507:
3502:
3496:
3494:
3488:
3487:
3485:
3484:
3479:
3474:
3464:
3459:
3454:
3449:
3444:
3439:
3434:
3429:
3424:
3419:
3414:
3409:
3407:Etilamfetamine
3404:
3399:
3394:
3389:
3384:
3379:
3374:
3369:
3364:
3359:
3354:
3349:
3344:
3339:
3334:
3329:
3324:
3318:
3316:
3302:
3296:
3295:
3279:
3278:
3271:
3264:
3256:
3250:
3249:
3235:
3234:External links
3232:
3230:
3229:
3199:
3181:(2): 656–666.
3170:
3149:
3131:(3): 408–414.
3118:
3116:
3113:
3110:
3109:
3083:
3047:
3024:"Fatty issues"
3014:
3003:on 9 June 2009
2987:
2947:
2928:
2902:
2868:
2857:on 13 May 2009
2838:
2806:
2780:
2762:
2732:
2699:
2692:
2671:
2620:
2589:(2): 656–666.
2569:
2538:
2509:(3): 270–279.
2489:
2462:(8): 704–709.
2436:
2406:
2379:(4): 428–435.
2362:
2321:
2302:(2): 221–224.
2296:Cancer Letters
2285:
2249:
2228:(3): 235–242.
2208:
2172:
2118:
2099:(7): 703–704.
2083:
2053:
2032:(2): 377–389.
2012:
1999:
1967:
1941:
1892:
1867:
1829:
1799:
1747:
1698:
1669:
1658:(1): 196–202.
1642:
1599:
1569:
1548:"Xenical EPAR"
1539:
1506:
1457:
1427:
1397:
1366:
1365:
1363:
1360:
1347:
1344:
1339:
1336:
1334:
1331:
1310:
1307:
1294:
1291:
1284:Public Citizen
1270:
1267:
1254:
1251:
1242:
1239:
1159:
1156:
1149:antiretroviral
1138:antiarrhythmic
1121:
1118:
1109:Absorption of
1106:
1103:
1056:
1053:
996:
993:
992:
991:
981:
972:
963:
952:
949:
935:
932:
916:blood pressure
898:
895:
887:Public Citizen
856:blood pressure
817:derivative of
794:used to treat
779:
778:
761:
760:
758:
757:
754:
752:
749:
741:
740:
739:
736:
735:
733:
732:
729:
721:
720:
719:
716:
715:
713:
712:
704:
702:
694:
693:
687:
681:
680:
677:
668:
662:
657:
651:
650:
646:
645:
635:
627:
626:
624:
623:
610:
608:
595:
594:
592:
591:
583:
581:
575:
574:
572:
571:
563:
561:
555:
554:
552:
551:
543:
541:
535:
534:
532:
531:
523:
521:
515:
514:
512:
511:
503:
501:
495:
494:
492:
491:
483:
481:
475:
474:
472:
471:
463:
461:
455:
454:
452:
451:
443:
441:
430:
429:
427:
426:
418:
416:
410:
409:
407:
406:
387:
379:
378:
377:
374:
373:
369:
368:
365:
359:
358:
355:
346:
345:
339:
333:
332:
329:
323:
322:
319:
313:
312:
305:
304:
302:
301:
292:
279:
266:
255:
241:
239:
233:
232:
228:
227:
225:
224:
211:
209:
203:
202:
197:
195:administration
189:
188:
186:
185:
183:
173:
171:
163:
162:
160:
159:
142:
125:
107:
105:
99:
98:
91:
85:
84:
77:
67:
66:
63:
59:
58:
55:
49:
48:
44:
43:
35:
34:
15:
9:
6:
4:
3:
2:
7636:
7625:
7622:
7620:
7617:
7615:
7612:
7610:
7607:
7605:
7602:
7600:
7597:
7595:
7592:
7590:
7587:
7586:
7584:
7574:
7564:
7563:
7560:
7547:
7546:
7537:
7536:
7533:
7527:
7524:
7522:
7521:
7517:
7515:
7512:
7510:
7507:
7506:
7504:
7500:
7494:
7493:
7489:
7487:
7486:
7482:
7480:
7479:
7475:
7473:
7472:
7468:
7466:
7465:
7461:
7460:
7458:
7454:
7444:
7441:
7439:
7436:
7434:
7431:
7429:
7428:John K. Smith
7426:
7424:
7421:
7419:
7416:
7414:
7411:
7410:
7408:
7404:
7398:
7395:
7393:
7390:
7388:
7385:
7383:Jesse Goodman
7382:
7380:
7377:
7375:
7372:
7370:
7367:
7365:
7362:
7360:
7357:
7355:
7352:
7350:
7349:Emma Walmsley
7347:
7345:
7342:
7341:
7339:
7333:
7330:
7326:
7316:
7313:
7311:
7308:
7306:
7303:
7301:
7298:
7296:
7293:
7291:
7288:
7286:
7283:
7281:
7278:
7276:
7273:
7271:
7268:
7266:
7263:
7260:
7258:
7255:
7253:
7250:
7248:
7245:
7243:
7240:
7238:
7235:
7233:
7230:
7228:
7225:
7223:
7220:
7218:
7215:
7212:
7210:
7207:
7206:
7204:
7200:
7190:
7189:
7184:
7181:
7179:
7176:
7174:
7171:
7169:
7166:
7164:
7161:
7159:
7156:
7154:
7151:
7149:
7146:
7144:
7141:
7139:
7136:
7134:
7131:
7129:
7126:
7124:
7121:
7119:
7116:
7114:
7111:
7109:
7106:
7104:
7101:
7099:
7096:
7094:
7091:
7089:
7086:
7085:
7083:
7079:
7073:
7072:
7067:
7064:
7062:
7059:
7057:
7054:
7052:
7049:
7047:
7044:
7042:
7041:Paxil/Seroxat
7039:
7037:
7034:
7032:
7029:
7027:
7024:
7022:
7019:
7017:
7014:
7012:
7009:
7007:
7004:
7002:
6999:
6997:
6994:
6993:
6991:
6987:
6984:
6980:
6977:
6973:
6967:
6964:
6962:
6959:
6957:
6954:
6952:
6949:
6947:
6944:
6942:
6939:
6937:
6934:
6932:
6929:
6927:
6924:
6922:
6919:
6917:
6916:Beecham Group
6914:
6912:
6909:
6908:
6906:
6902:Predecessors,
6900:
6892:
6888:
6884:
6877:
6874:
6872:
6869:
6867:
6864:
6862:
6859:
6857:
6854:
6853:
6851:
6847:
6844:
6840:
6836:
6829:
6824:
6822:
6817:
6815:
6810:
6809:
6806:
6794:
6793:
6789:
6786:
6785:
6782:
6776:
6773:
6771:
6768:
6765:
6764:
6761:
6758:
6756:
6753:
6751:
6748:
6746:
6743:
6741:
6738:
6736:
6733:
6731:
6728:
6726:
6723:
6721:
6718:
6716:
6713:
6711:
6708:
6706:
6703:
6701:
6698:
6696:
6693:
6691:
6688:
6686:
6685:Sulfisoxazole
6683:
6681:
6678:
6676:
6673:
6671:
6668:
6666:
6663:
6661:
6658:
6656:
6653:
6651:
6648:
6646:
6643:
6641:
6638:
6636:
6633:
6631:
6628:
6626:
6623:
6621:
6618:
6616:
6613:
6611:
6608:
6606:
6603:
6601:
6598:
6596:
6593:
6591:
6588:
6586:
6583:
6581:
6578:
6576:
6573:
6571:
6568:
6566:
6563:
6561:
6560:Phenobarbital
6558:
6556:
6553:
6551:
6548:
6546:
6543:
6541:
6538:
6536:
6533:
6531:
6528:
6526:
6523:
6521:
6518:
6516:
6513:
6511:
6508:
6506:
6503:
6501:
6498:
6496:
6493:
6491:
6488:
6486:
6483:
6481:
6478:
6476:
6473:
6471:
6468:
6466:
6463:
6461:
6458:
6456:
6452:
6448:
6446:
6445:Levothyroxine
6443:
6441:
6438:
6436:
6433:
6431:
6429:
6425:
6423:
6420:
6418:
6415:
6413:
6410:
6408:
6407:Guggulsterone
6405:
6403:
6400:
6398:
6395:
6393:
6390:
6388:
6385:
6383:
6380:
6378:
6375:
6373:
6370:
6368:
6365:
6363:
6360:
6358:
6355:
6353:
6350:
6348:
6345:
6343:
6340:
6338:
6335:
6333:
6330:
6328:
6325:
6323:
6320:
6318:
6315:
6313:
6310:
6308:
6305:
6303:
6302:Dicloxacillin
6300:
6298:
6295:
6293:
6290:
6287:
6283:
6280:
6277:
6273:
6270:
6268:
6267:Dexamethasone
6265:
6263:
6260:
6258:
6255:
6253:
6250:
6248:
6245:
6243:
6240:
6238:
6235:
6233:
6230:
6228:
6225:
6223:
6220:
6218:
6215:
6213:
6210:
6208:
6205:
6203:
6202:Cephaloridine
6200:
6198:
6195:
6193:
6190:
6188:
6185:
6183:
6180:
6178:
6175:
6173:
6170:
6168:
6165:
6163:
6160:
6158:
6155:
6153:
6150:
6148:
6145:
6143:
6140:
6138:
6135:
6133:
6130:
6128:
6125:
6123:
6120:
6118:
6115:
6113:
6110:
6108:
6105:
6103:
6100:
6098:
6095:
6092:
6091:
6089:
6084:
6078:
6072:
6069:
6067:
6064:
6062:
6059:
6057:
6054:
6052:
6049:
6047:
6044:
6042:
6039:
6037:
6034:
6032:
6029:
6027:
6024:
6022:
6019:
6017:
6014:
6012:
6009:
6006:
6005:
6002:
6001:Valproic acid
5999:
5997:
5994:
5992:
5989:
5987:
5984:
5982:
5979:
5977:
5974:
5972:
5969:
5967:
5964:
5962:
5961:Phenobarbital
5959:
5957:
5954:
5952:
5949:
5947:
5944:
5942:
5939:
5937:
5934:
5932:
5929:
5927:
5924:
5922:
5919:
5917:
5914:
5912:
5909:
5906:
5902:
5899:
5897:
5894:
5892:
5889:
5887:
5884:
5882:
5879:
5877:
5874:
5872:
5869:
5867:
5864:
5862:
5861:Carbamazepine
5859:
5857:
5854:
5852:
5849:
5847:
5844:
5842:
5839:
5836:
5835:
5833:
5828:
5822:
5818:
5815:
5808:
5803:
5801:
5796:
5794:
5789:
5788:
5785:
5773:
5771:
5767:
5765:
5764:
5760:
5757:
5756:
5753:
5747:
5744:
5741:
5739:
5732:
5729:
5726:
5725:
5722:
5719:
5717:
5714:
5712:
5709:
5706:
5705:
5703:
5699:
5689:
5686:
5684:
5681:
5679:
5676:
5674:
5671:
5669:
5668:Maslinic acid
5666:
5664:
5661:
5658:
5657:
5655:
5652:
5647:
5641:
5638:
5636:
5633:
5631:
5628:
5626:
5623:
5621:
5618:
5616:
5613:
5611:
5608:
5606:
5603:
5601:
5598:
5596:
5593:
5591:
5588:
5586:
5583:
5580:
5579:
5577:
5574:
5569:
5563:
5560:
5558:
5555:
5553:
5550:
5548:
5545:
5543:
5540:
5538:
5535:
5533:
5530:
5528:
5525:
5523:
5520:
5518:
5515:
5513:
5510:
5508:
5505:
5503:
5500:
5497:
5496:
5494:
5492:
5488:
5482:
5479:
5476:
5475:
5472:
5469:
5467:
5464:
5462:
5459:
5457:
5454:
5452:
5449:
5447:
5444:
5442:
5439:
5437:
5434:
5432:
5429:
5427:
5424:
5422:
5419:
5417:
5414:
5412:
5409:
5407:
5404:
5402:
5399:
5397:
5394:
5392:
5389:
5387:
5384:
5382:
5379:
5377:
5374:
5372:
5369:
5367:
5364:
5362:
5359:
5357:
5351:
5349:
5346:
5343:
5342:
5340:
5335:
5329:
5326:
5322:
5316:
5312:
5302:
5299:
5297:
5294:
5292:
5289:
5287:
5284:
5282:
5279:
5277:
5274:
5272:
5269:
5267:
5264:
5262:
5259:
5257:
5254:
5252:
5249:
5247:
5244:
5242:
5239:
5237:
5234:
5232:
5229:
5227:
5224:
5222:
5219:
5217:
5214:
5211:
5210:
5208:
5203:
5197:
5194:
5190:
5184:
5180:
5166:
5163:
5161:
5158:
5156:
5153:
5151:
5148:
5146:
5143:
5141:
5138:
5136:
5133:
5131:
5128:
5126:
5123:
5121:
5118:
5116:
5113:
5112:
5110:
5106:
5103:
5100:
5095:
5085:
5082:
5080:
5077:
5075:
5072:
5070:
5067:
5065:
5062:
5060:
5057:
5055:
5052:
5050:
5047:
5045:
5042:
5040:
5037:
5036:
5034:
5030:
5024:
5021:
5019:
5016:
5014:
5011:
5009:
5006:
5004:
5001:
4999:
4996:
4994:
4991:
4989:
4986:
4984:
4981:
4979:
4976:
4974:
4971:
4969:
4966:
4964:
4961:
4959:
4956:
4954:
4951:
4949:
4946:
4944:
4941:
4940:
4938:
4934:
4931:
4928:
4923:
4913:
4910:
4908:
4905:
4904:
4902:
4898:
4892:
4889:
4887:
4884:
4882:
4879:
4877:
4874:
4872:
4869:
4867:
4864:
4862:
4859:
4857:
4854:
4853:
4851:
4847:
4844:
4842:
4830:
4820:
4817:
4815:
4812:
4810:
4807:
4805:
4802:
4800:
4797:
4795:
4792:
4790:
4787:
4785:
4782:
4780:
4777:
4776:
4774:
4770:
4764:
4761:
4759:
4756:
4754:
4751:
4749:
4746:
4744:
4741:
4739:
4736:
4734:
4731:
4729:
4726:
4724:
4721:
4719:
4716:
4714:
4711:
4709:
4706:
4704:
4701:
4699:
4696:
4694:
4691:
4689:
4686:
4684:
4681:
4679:
4676:
4674:
4671:
4669:
4666:
4664:
4661:
4659:
4656:
4654:
4651:
4649:
4646:
4644:
4641:
4639:
4636:
4634:
4631:
4629:
4626:
4624:
4621:
4619:
4616:
4614:
4613:Caryophyllene
4611:
4609:
4606:
4604:
4601:
4599:
4596:
4594:
4591:
4589:
4586:
4584:
4581:
4579:
4576:
4574:
4571:
4569:
4566:
4564:
4561:
4559:
4556:
4554:
4551:
4549:
4546:
4544:
4541:
4539:
4536:
4534:
4531:
4530:
4528:
4524:
4521:
4516:
4507:
4497:
4494:
4492:
4489:
4487:
4484:
4482:
4479:
4477:
4474:
4472:
4469:
4467:
4464:
4462:
4459:
4457:
4454:
4452:
4449:
4447:
4444:
4442:
4439:
4437:
4434:
4432:
4429:
4427:
4424:
4422:
4419:
4417:
4414:
4412:
4409:
4407:
4404:
4403:
4401:
4397:
4391:
4390:Zevaquenabant
4388:
4386:
4383:
4381:
4378:
4376:
4373:
4371:
4368:
4366:
4363:
4361:
4358:
4356:
4353:
4352:
4350:
4346:
4340:
4337:
4335:
4332:
4330:
4327:
4325:
4322:
4320:
4317:
4315:
4312:
4310:
4307:
4305:
4302:
4300:
4297:
4295:
4292:
4290:
4287:
4285:
4282:
4280:
4279:Levonantradol
4277:
4275:
4272:
4270:
4267:
4265:
4262:
4260:
4257:
4255:
4252:
4250:
4247:
4245:
4242:
4240:
4237:
4235:
4232:
4230:
4227:
4225:
4222:
4220:
4217:
4215:
4212:
4210:
4207:
4205:
4202:
4200:
4197:
4195:
4192:
4190:
4187:
4185:
4182:
4180:
4177:
4175:
4172:
4170:
4167:
4165:
4162:
4160:
4157:
4155:
4152:
4150:
4147:
4145:
4142:
4140:
4137:
4135:
4132:
4130:
4127:
4125:
4122:
4120:
4117:
4116:
4114:
4112:
4110:
4101:
4098:
4093:
4084:
4081:
4077:
4071:
4067:
4063:
4060:
4053:
4048:
4046:
4041:
4039:
4034:
4033:
4030:
4014:
4012:
4009:
4008:
4006:
4003:
4000:
3997:
3995:
3992:
3991:
3987:
3981:
3978:
3976:
3973:
3971:
3968:
3966:
3963:
3961:
3960:Setmelanotide
3958:
3956:
3953:
3951:
3948:
3946:
3943:
3941:
3938:
3936:
3933:
3931:
3928:
3927:
3925:
3921:
3915:
3912:
3911:
3909:
3907:
3903:
3897:
3894:
3892:
3889:
3887:
3884:
3882:
3879:
3877:
3874:
3873:
3871:
3867:
3861:
3858:
3856:
3853:
3852:
3850:
3848:
3842:
3835:
3831:
3828:
3827:
3825:
3823:
3819:
3812:
3809:
3806:
3805:+cagrilintide
3802:
3799:
3797:
3794:
3792:
3791:Oxyntomodulin
3789:
3787:
3784:
3782:
3779:
3776:
3773:
3771:
3768:
3766:
3763:
3761:
3758:
3756:
3753:
3751:
3748:
3747:
3745:
3743:
3739:
3735:
3731:
3727:
3721:
3718:
3716:
3713:
3711:
3708:
3706:
3703:
3701:
3698:
3696:
3693:
3691:
3688:
3687:
3685:
3683:
3677:
3667:
3664:
3662:
3659:
3657:
3654:
3652:
3649:
3647:
3644:
3642:
3639:
3637:
3636:Phenmetrazine
3634:
3632:
3629:
3627:
3624:
3622:
3619:
3617:
3614:
3612:
3609:
3606:
3602:
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3506:
3503:
3501:
3498:
3497:
3495:
3493:
3489:
3483:
3480:
3478:
3477:Xylopropamine
3475:
3472:
3468:
3465:
3463:
3460:
3458:
3455:
3453:
3450:
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3378:
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3373:
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3365:
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3360:
3358:
3355:
3353:
3352:Benzphetamine
3350:
3348:
3345:
3343:
3340:
3338:
3335:
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3330:
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3325:
3323:
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2182:
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2164:
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2123:
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2106:
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2098:
2094:
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2071:
2067:
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2040:
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2031:
2027:
2023:
2016:
2009:
2003:
1984:
1977:
1971:
1955:
1951:
1945:
1937:
1933:
1928:
1923:
1919:
1915:
1911:
1907:
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1896:
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1874:
1872:
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1836:
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1809:
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1791:
1786:
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1777:
1773:
1770:(7588): 299.
1769:
1765:
1761:
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1752:
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1739:
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1713:
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1324:
1318:
1316:
1306:
1302:
1300:
1290:
1287:
1285:
1281:
1276:
1269:United States
1266:
1264:
1260:
1250:
1248:
1238:
1235:
1233:
1232:
1227:
1222:
1220:
1216:
1212:
1208:
1204:
1200:
1199:triglycerides
1196:
1192:
1184:
1180:
1176:
1172:
1168:
1164:
1155:
1154:medications.
1153:
1150:
1146:
1142:
1139:
1135:
1131:
1127:
1117:
1115:
1112:
1102:
1100:
1096:
1092:
1087:
1082:
1080:
1077:, can induce
1076:
1073:
1069:
1068:
1062:
1061:breast cancer
1051:
1046:
1043:
1041:
1036:
1034:
1029:
1027:
1021:
1019:
1014:
1010:
1006:
1002:
990:
986:
982:
980:
976:
973:
971:
970:breastfeeding
967:
964:
961:
957:
953:
950:
948:
947:Malabsorption
945:
944:
943:
941:
931:
929:
925:
921:
917:
912:
908:
904:
894:
892:
888:
884:
880:
876:
872:
868:
863:
861:
857:
852:
848:
843:
841:
837:
836:
832:
828:
825:inhibitor of
824:
820:
816:
811:
809:
805:
801:
797:
793:
789:
785:
775:
768:
762:
753:
748:
747:
744:
737:
728:
727:
724:
717:
710:
706:
705:
703:
700:
695:
688:
686:
682:
658:
656:
652:
647:
643:
639:
636:
634:
632:ECHA InfoCard
628:
620:
616:
615:DTXSID8023395
612:
611:
609:
600:
596:
589:
585:
584:
582:
580:
576:
569:
565:
564:
562:
560:
556:
549:
545:
544:
542:
540:
536:
529:
525:
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522:
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516:
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489:
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109:
108:
106:
104:
100:
96:
92:
90:
86:
82:
78:
76:
72:
68:
64:
60:
57:Xenical, Alli
56:
54:
50:
47:Clinical data
45:
41:
36:
32:
27:
19:
7544:
7520:Side Effects
7518:
7490:
7483:
7476:
7469:
7462:
7438:Andrew Witty
7423:Mahlon Kline
7374:Vivienne Cox
7187:
7143:H5N1 vaccine
7070:
7000:
6904:acquisitions
6842:Subsidiaries
6790:
6770:Ketoconazole
6767:Antagonists:
6766:
6740:Troglitazone
6715:Tetracycline
6670:Spiroxatrine
6615:Quingestrone
6610:Progesterone
6595:Pregnenolone
6590:Pregnanolone
6580:Pregnanediol
6575:Prednisolone
6544:
6500:Mifepristone
6427:
6402:Griseofulvin
6382:Fenbendazole
6367:Famprofazone
6362:Erythromycin
6357:Epothilone B
6342:Eburnamonine
6237:Clotrimazole
6227:Clofenvinfos
6162:Antimycotics
6093:
6056:Okadaic acid
6008:Antagonists:
6007:
5996:Troglitazone
5931:Mifepristone
5926:Methoxychlor
5921:Griseofulvin
5916:Ellagic acid
5896:Cypermethrin
5886:Clotrimazole
5837:
5770:Cannabinoids
5768:
5761:
5745:
5733:
5727:
5707:
5688:Ursolic acid
5682:
5659:
5581:
5498:
5477:
5396:JNJ-42165279
5344:
5212:
5044:CID-16020046
4416:Cannabigerol
4334:WIN 55,212-2
4105:
3890:
3834:+semaglutide
3830:Cagrilintide
3786:Orforglipron
3656:Pyrovalerone
3605:+phentermine
3601:Fenfluramine
3596:Fenbutrazate
3482:Zylofuramine
3417:Fenethylline
3347:Amphetaminil
3332:Amfepentorex
3309:Amphetamines
3244:
3208:
3204:
3178:
3174:
3160:(27): 7768.
3157:
3153:
3128:
3124:
3100:. Retrieved
3086:
3078:
3071:. Retrieved
3060:
3050:
3038:. Retrieved
3034:the original
3027:
3017:
3005:. Retrieved
3001:the original
2990:
2978:. Retrieved
2950:
2931:
2919:. Retrieved
2915:the original
2905:
2893:. Retrieved
2884:
2859:. Retrieved
2855:the original
2841:
2829:. Retrieved
2818:
2809:
2797:. Retrieved
2793:
2783:
2775:the original
2765:
2755:19 September
2753:. Retrieved
2744:
2735:
2723:. Retrieved
2681:
2674:
2662:. Retrieved
2637:
2633:
2623:
2611:. Retrieved
2586:
2582:
2572:
2560:. Retrieved
2551:
2541:
2506:
2502:
2492:
2459:
2455:
2439:
2427:. Retrieved
2409:
2376:
2372:
2365:
2338:
2334:
2324:
2299:
2295:
2288:
2263:
2259:
2252:
2225:
2221:
2211:
2199:. Retrieved
2188:
2175:
2140:
2136:
2096:
2092:
2086:
2076:20 September
2074:. Retrieved
2056:
2029:
2025:
2015:
2007:
2002:
1990:. Retrieved
1983:the original
1970:
1958:. Retrieved
1944:
1909:
1905:
1895:
1883:. Retrieved
1858:. Retrieved
1847:
1820:. Retrieved
1811:
1802:
1767:
1763:
1715:
1711:
1701:
1684:
1678:
1672:
1655:
1651:
1645:
1612:
1608:
1602:
1592:20 September
1590:. Retrieved
1581:
1572:
1562:20 September
1560:. Retrieved
1551:
1542:
1532:19 September
1530:. Retrieved
1521:
1499:19 September
1497:. Retrieved
1488:
1450:19 September
1448:. Retrieved
1439:
1430:
1420:19 September
1418:. Retrieved
1409:
1400:
1390:19 September
1388:. Retrieved
1379:
1370:
1349:
1341:
1319:
1312:
1303:
1296:
1288:
1272:
1256:
1244:
1241:Legal status
1236:
1229:
1223:
1188:
1123:
1120:Interactions
1108:
1099:colon cancer
1083:
1065:
1058:
1048:
1044:
1037:
1030:
1026:low-fat diet
1022:
1001:side effects
999:The primary
998:
995:Side effects
938:Orlistat is
937:
900:
897:Medical uses
870:
867:side effects
864:
844:
833:
812:
787:
783:
782:
771:
765:
588:ChEMBL175247
401:
397:
393:
389:
357:1 to 2 hours
350:Elimination
237:Legal status
231:Legal status
103:License data
18:
7387:Judy Lewent
6755:Zafirlukast
6725:Thiothixene
6705:Terconazole
6655:Simvastatin
6530:Nisoldipine
6525:Nilvadipine
6510:Nicardipine
6480:Metacycline
6307:Dimercaprol
6262:Demecolcine
6222:Clindamycin
6217:Ciglitazone
6167:Artemisinin
6147:Ambrisentan
6051:Nigramide J
5986:Telmisartan
5946:Nicardipine
5856:Benfuracarb
5851:Artemisinin
5708:Precursors:
5660:Inhibitors:
5582:Inhibitors:
5557:Pristimerin
5499:Inhibitors:
5478:Activators:
5391:JNJ-1661010
5376:Biochanin A
5371:BIA 10-2474
5345:Inhibitors:
5246:Guineensine
5241:Cannabidiol
5213:Inhibitors:
5183:Transporter
5165:PSN-632,408
5160:PSN-375,963
5079:PSB-SB-1203
5074:PSB-SB-1202
5039:Cannabidiol
5032:Antagonists
4983:GSK-494581A
4900:Antagonists
4876:Cannabidiol
4794:Cannabidiol
4772:Antagonists
4763:Virodhamine
4718:PF-03550096
4638:GW-842,166X
4603:AZ-11713908
4496:Virodhamine
4436:Ibipinabant
4431:Hemopressin
4411:Cannabidiol
4399:Antagonists
4365:Monlunabant
4314:Pravadoline
4229:Epicatechin
4184:AZ-11713908
4139:AB-CHMINACA
4001:from market
3950:Metreleptin
3886:Mitratapide
3881:Dirlotapide
3811:Tirzepatide
3801:Semaglutide
3796:Retatrutide
3781:Liraglutide
3770:Ecnoglutide
3765:Danuglipron
3695:Ibipinabant
3682:antagonists
3680:Cannabinoid
3666:Tesofensine
3661:Sibutramine
3591:Difemetorex
3575:+naltrexone
3561:Atomoxetine
3530:Terbutaline
3505:Clenbuterol
3471:+topiramate
3467:Phentermine
3422:Fenproporex
3382:Clortermine
3372:Clobenzorex
3342:Amphetamine
3337:Amfepramone
3040:26 November
2895:10 February
2429:16 November
2201:11 December
1578:"Alli EPAR"
1356:sibutramine
1211:fatty acids
1126:ciclosporin
1111:fat-soluble
1105:Precautions
1075:trastuzumab
1005:steatorrhea
956:gallbladder
911:significant
875:steatorrhea
847:weight loss
821:, a potent
692: g·mol
638:100.167.400
568:CHEBI:94686
372:Identifiers
89:MedlinePlus
62:Other names
53:Trade names
7624:Formamides
7583:Categories
7456:Litigation
7443:Chris Gent
7392:Urs Rohner
7300:Parodontax
7108:Engerix-B
6921:Block Drug
6735:Tianeptine
6700:Tenylidone
6695:Tacrolimus
6640:Rimexolone
6630:Rifampicin
6570:Plicamycin
6555:Paclitaxel
6540:Omeprazole
6520:Nifedipine
6495:Mevastatin
6490:Metyrapone
6470:Lovastatin
6465:Loratadine
6422:Hyperforin
6412:Haloprogin
6377:Felodipine
6352:Enzacamene
6332:Dronabinol
6297:Diclazuril
6276:prasterone
6232:Chloroxine
6207:Cephradine
6177:Bile acids
5991:Tolnaftate
5956:Permethrin
5941:Nevirapine
5936:Nefazodone
5905:prasterone
5866:Carvedilol
5846:Amiodarone
5817:modulators
5411:LY-2183240
5406:Kaempferol
5321:modulators
5251:LY-2183240
5216:5'-DMH-CBD
5189:modulators
5135:AS-1269574
5130:AR-231,453
5120:Anandamide
5069:PSB-SB-487
4973:CID1792579
4968:CID1252842
4963:CID1011163
4871:Anandamide
4819:WIN 56,098
4814:WIN 54,461
4809:SR-144,528
4608:Cannabinol
4598:Anandamide
4481:Selonabant
4476:Rosonabant
4441:LY-320,135
4380:Taranabant
4375:Surinabant
4370:Rimonabant
4189:Cannabinol
4174:Anandamide
4106:(abridged,
4062:modulators
3975:Zonisamide
3965:Topiramate
3955:Naltrexone
3935:Bimagrumab
3906:Uncouplers
3896:Simmondsin
3876:Cetilistat
3860:Lorcaserin
3760:Cotadutide
3755:Cinchonine
3720:Taranabant
3715:Surinabant
3710:Rosonabant
3705:Rimonabant
3611:Manifaxine
3566:Benfluorex
3525:Synephrine
3432:Furfenorex
3327:Amfecloral
3300:Stimulants
3287:Anorectics
3241:"Orlistat"
3102:24 January
2921:22 January
2861:7 February
2741:"Orlistat"
2725:22 January
1362:References
1327:KRKA d. d.
1234:parasite.
1207:hydrolyzed
1179:C-terminus
1175:N-terminus
1141:amiodarone
1079:cell death
792:medication
697:3D model (
685:Molar mass
528:95M8R751W8
499:ChemSpider
459:IUPHAR/BPS
423:96829-58-2
414:CAS Number
381:IUPAC name
337:Metabolism
321:Negligible
7589:Aldehydes
7526:Study 329
7337:Directors
7335:Board of
7310:Sensodyne
7290:Nicorette
7247:Emergen-C
7242:ChapStick
7222:BC Powder
7217:Aquafresh
7158:Pandemrix
7128:Hepatyrix
7026:Flixonase
7006:Augmentin
6660:Sirolimus
6650:Ritonavir
6645:Riodipine
6635:Rifaximin
6620:Reserpine
6605:Proadifen
6550:Oxatomide
6505:Nafcillin
6475:Meclizine
6337:Droxidopa
6317:Docetaxel
6242:Colforsin
6192:Bumecaine
6182:Bithionol
6094:Agonists:
6071:T-0901317
6046:Meclizine
5976:Reserpine
5966:Phenytoin
5951:Octicizer
5911:Efavirenz
5838:Agonists:
5738:receptor)
5381:Genistein
4978:CP 55,940
4743:Tedalinab
4723:S-444,823
4683:L-759,656
4678:L-759,633
4628:CP 55,940
4568:A-836,339
4563:A-834,735
4558:A-796,260
4466:PF-514273
4461:Otenabant
4451:NESS-0327
4421:Drinabant
4284:Menabitan
4274:L-759,633
4204:CP 55,940
4199:CP 47,497
4109:full list
4011:Phase III
3999:Withdrawn
3945:Metformin
3930:Beloranib
3775:Exenatide
3700:Otenabant
3690:Drinabant
3646:Pipradrol
3571:Bupropion
3535:Yohimbine
3510:Ephedrine
3500:Albuterol
3447:Mefenorex
3397:Ephedrine
3362:Cathinone
2831:10 August
2552:e-surgery
2452:;
2143:: f1936.
1849:USA Today
1822:18 August
1203:intestine
1169:of human
1055:Long-term
985:bile duct
966:Pregnancy
928:diastolic
831:bacterium
819:lipstatin
815:saturated
363:Excretion
352:half-life
274: P (
193:Routes of
167:Pregnancy
81:Monograph
75:Drugs.com
7619:Lactones
7573:Medicine
7545:Category
7295:NiQuitin
7285:Nicoderm
7280:Lucozade
7275:Horlicks
7257:Excedrin
7232:Caltrate
7178:Shingrix
7168:Rabavert
7163:Pediarix
7138:Infanrix
7118:FluLaval
7103:Cervarix
7098:Boostrix
7081:Vaccines
7056:Ventolin
7046:Serlipet
7036:Lamictal
7031:Hycamtin
7016:Beconase
6975:Products
6787:See also
6675:SR-12813
6565:Piperine
6545:Orlistat
6515:Nicotine
6387:Fentanyl
6372:Febantel
6347:Ecopipam
6312:Dinaline
6197:Cafestol
6187:Bosentan
6061:PK-11195
5758:See also
5512:JJKK 048
5502:ABX-1431
5271:SB-FI-26
5140:MBX-2982
5108:Agonists
4936:Agonists
4849:Agonists
4799:Honokiol
4693:Magnolol
4648:JTE 7-31
4623:CBS-0550
4526:Agonists
4385:TM-38837
4339:Yangonin
4309:Oleamide
4289:Nabilone
4239:Honokiol
4103:Agonists
4070:Receptor
3970:ZGN-1061
3891:Orlistat
3738:and / or
3616:Mazindol
3556:Aminorex
3462:Pentorex
3427:Fludorex
3412:Etolorex
3377:Cloforex
3225:22674877
3195:20028024
3096:Archived
3073:8 August
3067:Archived
2971:Archived
2956:Rogan JE
2939:Archived
2889:Archived
2825:Archived
2799:20 April
2749:Archived
2719:Archived
2658:Archived
2654:22674877
2613:19 April
2607:Archived
2603:20028024
2556:Archived
2533:10730683
2476:17618296
2423:Archived
2401:24389189
2393:12723464
2316:16377080
2280:15870086
2195:Archived
2181:Kolata G
2167:23585064
2113:21482850
2070:Archived
2048:16767304
1954:Archived
1936:33454957
1885:18 April
1854:Archived
1816:Archived
1794:17237299
1742:15266516
1637:23618845
1586:Archived
1556:Archived
1526:Archived
1522:DailyMed
1493:Archived
1489:DailyMed
1444:Archived
1414:Archived
1384:Archived
1215:GI tract
1177:= blue,
1114:vitamins
1067:in vitro
975:Anorexia
954:Reduced
924:systolic
784:Orlistat
774:(verify)
479:DrugBank
343:GI tract
207:ATC code
200:By mouth
182: B1
169:category
156:Orlistat
139:Orlistat
134:DailyMed
23:Orlistat
7265:Geritol
7261:Flonase
7237:Centrum
7227:Biotene
7209:Actifed
7183:Twinrix
7173:Rotarix
7133:Hiberix
7113:Fluarix
7093:Bexsero
7051:Tagamet
7011:Avandia
6982:Current
6849:Current
6775:Sesamin
6760:Zeranol
6690:Suramin
6460:LOE-908
6152:AMI-193
6066:S-07662
5981:TCPOBOP
5876:Chrysin
5743:ARN-272
5728:Others:
5615:LEI-106
5590:JZP-430
5585:JZP-169
5562:URB-602
5532:JZP-361
5527:JZL-195
5522:JZL-184
5471:URB-597
5456:TAK 21d
5431:PF-3845
5401:JZL-195
5301:WOBE492
5296:WOBE491
5291:WOBE490
5281:URB-597
5276:UCM-707
5236:Arvanil
5226:AM-1172
5155:Olvanil
4907:PSB-CB5
4804:JTE-907
4789:BML-190
4728:SER-601
4703:Nabitan
4673:JWH-133
4663:JWH-018
4658:JWH-015
4653:JWH-007
4593:AM-2232
4588:AM-1241
4583:AM-1235
4578:AM-1221
4573:AM-1172
4446:MK-9470
4406:AM-6545
4360:INV-202
4294:Nabitan
4264:JWH-073
4259:JWH-018
4254:JWH-015
4249:JWH-007
4179:Arvanil
4169:AM-2232
4164:AM-2201
4159:AM-1235
4154:AM-1221
4149:AM-1220
4144:AM-1172
4076:ligands
3750:AMG 133
3539:Yohimbe
3515:Ephedra
3402:Ephedra
3357:Cathine
3145:8308867
3007:20 June
2980:8 April
2524:6145169
2484:2105534
2357:9791143
2244:9918478
2158:3624963
2064:. U.S.
1992:8 April
1960:13 July
1952:. NHS.
1927:8094237
1785:1796695
1733:8078201
1629:8626884
1201:in the
1195:enzymes
1191:lipases
979:Bulimia
903:obesity
891:Generic
823:natural
804:caloric
796:obesity
788:Xenical
690:495.745
655:Formula
508:2298564
488:DB01083
448:3034010
434:PubChem
396:)-1-((2
341:In the
331:>99%
262::
223:)
217: (
215:A08AB01
154::
136::
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95:a601244
7559:Portal
7328:People
7305:Ribena
7202:Former
7153:Menveo
7148:Kinrix
7123:Havrix
7088:Arexvy
7066:Zantac
7021:Boniva
6996:Advair
6989:Pharma
6891:Haleon
6886:Former
6871:Tesaro
6282:DHEA-S
6122:AA-861
5701:Others
5651:ABHD12
5640:WWL-70
5635:UCM710
5547:MJN110
5537:KML 29
5517:JW 642
5481:PDP-EA
5466:UCM710
5461:TC-F 2
5436:PF-750
5361:AM-404
5353:AACOCF
5315:Enzyme
5286:VDM-11
5261:OMDM-2
5256:O-2093
5221:AM-404
5125:APD668
5099:GPR119
5064:O-1918
5059:ML-193
5054:ML-192
5049:ML-191
5008:O-1602
5003:ML-186
4998:ML-185
4993:ML-184
4958:AM-251
4948:2-ALPI
4912:O-1918
4891:O-1602
4881:NADGly
4784:AM-630
4738:UR-144
4698:MDA-19
4668:JWH-73
4643:HU-308
4471:PipISB
4456:O-2050
4355:AM-251
4329:UR-144
4304:O-1812
4269:Kavain
4244:HU-210
3994:WHO-EM
3923:Others
3845:5-HT2C
3822:DACRAs
3223:
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2664:9 June
2652:
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2562:9 June
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1860:9 June
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1143:. The
1009:flatus
885:group
723:SMILES
579:ChEMBL
548:D04028
287:
264:℞-only
250:
149:
132:
122:by INN
115:
7502:Other
7406:Other
7213:Advil
6931:Glaxo
6878:(85%)
5881:CITCO
5630:ML296
5625:ML295
5620:ML294
5610:KT203
5605:KT195
5600:KT185
5595:KT182
5573:ABHD6
5451:SA-57
5446:SA-47
5201:eCBTs
4927:GPR55
4866:AM251
4839:GPR18
4834:NAGly
4618:CB-13
4491:VCHSR
4194:CB-13
3980:Water
3855:5-HTP
3730:GLP-1
3549:Other
2974:(PDF)
2963:(PDF)
2480:S2CID
2397:S2CID
1986:(PDF)
1979:(PDF)
1633:S2CID
1440:(emc)
1410:(emc)
1380:(emc)
1219:feces
1086:colon
743:InChI
699:JSmol
559:ChEBI
367:Fecal
7315:Tums
7188:more
7071:more
7001:Alli
6453:and
6272:DHEA
6036:AITC
5901:DHEA
5731:2-PG
5716:NAPE
5673:MAFP
5542:MAFP
5507:IDFP
5491:MAGL
5416:MAFP
5386:IDFP
5333:FAAH
4861:ACPA
4753:THCV
4708:NADA
4533:2-AG
4486:THCV
4299:NADA
4224:EGCG
4119:2-AG
3437:Khat
3221:PMID
3191:PMID
3141:PMID
3104:2010
3075:2017
3042:2009
3009:2009
2982:2007
2923:2009
2897:2007
2863:2007
2833:2006
2801:2023
2757:2022
2727:2009
2688:ISBN
2666:2020
2650:PMID
2615:2019
2599:PMID
2564:2020
2529:PMID
2472:PMID
2449:2PX6
2431:2014
2389:PMID
2353:PMID
2312:PMID
2276:PMID
2240:PMID
2222:JAMA
2203:2007
2163:PMID
2109:PMID
2078:2022
2044:PMID
1994:2007
1962:2013
1932:PMID
1887:2018
1862:2009
1824:2017
1790:PMID
1738:PMID
1716:2003
1625:PMID
1594:2022
1564:2022
1534:2022
1501:2022
1452:2022
1422:2022
1392:2022
1338:Cost
977:and
968:and
942:in:
926:and
920:mmHg
539:KEGG
519:UNII
468:5277
392:)-((
311:data
71:AHFS
7252:Eno
6835:GSK
6082:PXR
5826:CAR
5552:NAM
4219:ECG
4214:DEA
3734:GIP
3311:and
3291:A08
3213:doi
3183:doi
3179:132
3162:doi
3133:doi
2642:doi
2591:doi
2587:132
2519:PMC
2511:doi
2464:doi
2445:PDB
2381:doi
2343:doi
2339:339
2304:doi
2300:240
2268:doi
2230:doi
2226:281
2153:PMC
2145:doi
2141:346
2137:BMJ
2101:doi
2097:171
2034:doi
1922:PMC
1914:doi
1780:PMC
1772:doi
1768:334
1764:BMJ
1728:PMC
1720:doi
1689:doi
1660:doi
1617:doi
1152:HIV
922:in
604:EPA
438:CID
289:OTC
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