490:
467:
31:
712:
3164:
727:(MCL), with or without prior rituximab-containing chemoimmunotherapy treatment, is bendamustine with mitoxantrone and rituximab. In Germany in 2012 it has become the first line treatment of choice for indolent lymphoma. After trial results released in June 2012 showed that it more than doubled disease
1148:
Weide R, Hess G, Köppler H, Heymanns J, Thomalla J, Aldaoud A, et al. (July 2007). "High anti-lymphoma activity of bendamustine/mitoxantrone/rituximab in rituximab pretreated relapsed or refractory indolent lymphomas and mantle cell lymphomas. A multicenter phase II study of the German Low Grade
890:
Bendamustine received its first marketing approval in
Germany, where it is marketed under the tradename Ribomustin, by Astellas Pharma GmbH's licensee, Mundipharma International Corporation Limited. It is indicated as a single-agent or in combination with other anti-cancer agents for indolent
800:
This can lead to device failure, possible product contamination, and potential serious adverse health consequences, including skin reactions in health care professionals preparing and administering this product and the risk of small blood vessel blockage in
1408:
Lagos GG, Lentzsch S, Comenzo RL, Zonder JA, Osman K, Gould J, et al. (8 December 2017). "Long Term Follow up of
Patients with Relapsed/Refractory Systemic Light Chain (AL) Amyloidosis Treated with Bendamustine and Dexamethasone in a Phase 2 Study".
912:
In
October 2008, the FDA granted further approval to market Treanda for the treatment of indolent B-cell non-Hodgkin's lymphoma that has progressed during or within six months of treatment with rituximab or a rituximab-containing regimen.
1344:
775:
FDA issued a warning on March 11, 2015, not to use bendamustine solution with CSTDs, adapters and syringes which contain either polycarbonate or acrylonitrile-butadiene-styrene (ABS) due to the incompatibility with
954:
1224:
895:, multiple myeloma, and chronic lymphocytic leukemia. SymBio Pharmaceuticals Ltd. holds exclusive rights to develop and market bendamustine HCl in Japan and selected Asia Pacific Rim countries.
1352:
851:. Only free bendamustine is active. Elimination is biphasic with a half-life of 6–10 minutes and a terminal half-life of approximately 30 minutes. It is eliminated primarily through the
182:
751:, and include nausea, fatigue, vomiting, diarrhea, fever, constipation, loss of appetite, cough, headache, unintentional weight loss, difficulty breathing, rashes, and
3030:
771:
Bendamustine solution is not compatible with Closed System
Transfer Devices (CSTD) Situation: *Most CSTD vendors have adapted their system to become compatible.
3204:
946:
137:
867:(the former German Democratic Republic). Until 1990 it was available only in East Germany. East German researchers found that it was useful for treating
1216:
1442:
3209:
792:
PhaSealR & SpirosR CSTDs contain either polycarbonate or ABS can dissolve when coming into contact with bendamustine (which contains DMA).
1193:
1046:
61:
3090:
2142:
579:
565:
1315:
1971:
1951:
1936:
809:
Immediately, stop using all PhaSealR &/or SpirosR products including adapters when preparing & administering bendamustine.
909:
to market bendamustine in the US, where it is sold under the tradename
Treanda, for treatment of chronic lymphocytic leukemia.
815:
Continue to use all universal PPE & safety precautions for hazardous drugs when preparing & administering bendamustine.
2358:
3118:
1435:
1288:
Ozegowski W, Krebs D (June 1963). "Aminosäureantagonisten. III. ω--propion- bzw. -buttersäuren als potentielle
Cytostatika".
696:
607:
InChI=1S/C16H21Cl2N3O2/c1-20-14-6-5-12(21(9-7-17)10-8-18)11-13(14)19-15(20)3-2-4-16(22)23/h5-6,11H,2-4,7-10H2,1H3,(H,22,23)
2725:
624:
1877:
1833:
1711:
1420:
1636:
1076:
599:
3135:
1428:
112:
2152:
681:
284:
167:
93:
3199:
2771:
1773:
1663:
355:
2693:
2676:
2551:
2315:
1693:
1239:
1345:"Cephalon Receives FDA Approval for TREANDA to Treat Patients with Relapsed Indolent Non-Hodgkin's Lymphoma"
2425:
2021:
906:
868:
646:
485:
406:
2627:
446:
435:
2017:
1987:
3194:
3154:
1807:
978:"Pharmacokinetics and excretion of 14C-bendamustine in patients with relapsed or refractory malignancy"
1912:
2993:
2873:
2863:
1120:
1092:
892:
876:
728:
654:
3189:
3045:
2978:
2948:
2566:
1816:
1316:"Cephalon Receives FDA Approval for TREANDA, a Novel Chemotherapy for Chronic Lymphocytic Leukemia"
462:
1201:
1042:
71:
3184:
3123:
2848:
2563:
2049:
1897:
1824:
642:
123:
43:
812:
Only use polypropylene syringes with bendamustine. These syringes are translucent in appearance.
2928:
2918:
2651:
2493:
1323:
976:
Dubbelman AC, Rosing H, Darwish M, D'Andrea D, Bond M, Hellriegel E, et al. (March 2013).
227:
2200:
1847:
715:
Adult
Atypical Sporadic Burkitt Lymphoma successfully treated with Bendamustine and Rituximab
346:
2598:
2475:
1996:
872:
724:
415:
395:
310:
253:
130:
8:
2883:
2783:
2762:
2483:
2305:
2137:
1868:
1764:
301:
219:
489:
466:
1941:
1450:
1270:
1174:
1002:
977:
673:
1386:
3065:
2639:
1473:
1390:
1262:
1166:
1072:
1007:
695:
Bendamustine was approved for medical use in the United States in 2008. It is on the
195:
85:
1274:
3070:
2827:
2542:
2176:
2161:
1882:
1382:
1297:
1254:
1178:
1158:
1128:
1100:
997:
989:
925:. It is also being investigated in phase II trials for the non-cancer treatment of
880:
756:
748:
700:
650:
502:
205:
150:
947:"Prescription medicines: registration of new chemical entities in Australia, 2014"
335:
3168:
2509:
2471:
2262:
1684:
1599:
844:
237:
213:
3129:
2663:
2254:
1748:
1612:
1499:
1469:
1456:
926:
1258:
1162:
993:
3178:
3003:
2963:
2333:
2206:
2087:
2030:
1788:
1737:
1301:
1125:
World Health
Organization model list of essential medicines: 22nd list (2021)
903:
478:
22:
735:. The combination also left patients with fewer side effects than the older
3050:
3014:
2898:
2888:
2842:
2838:
2800:
2708:
2498:
2437:
2433:
2414:
2409:
2388:
2377:
2191:
2185:
2171:
2097:
2092:
2045:
1931:
1798:
1778:
1707:
1656:
1646:
1460:
1452:
1394:
1266:
1170:
1097:
World Health
Organization model list of essential medicines: 21st list 2019
1011:
864:
145:
3095:
3075:
3060:
3055:
3040:
2998:
2968:
2908:
2878:
2822:
2795:
2668:
2609:
2581:
2571:
2524:
2488:
2404:
2366:
2348:
2343:
2323:
2300:
2271:
2249:
2229:
2219:
2070:
2055:
2035:
1921:
1852:
1838:
1793:
1726:
1721:
1698:
1673:
1641:
1584:
1547:
1524:
1509:
1504:
1489:
884:
825:
658:
79:
1133:
1105:
711:
375:
3085:
2988:
2983:
2958:
2953:
2943:
2938:
2933:
2903:
2893:
2858:
2853:
2833:
2788:
2776:
2751:
2746:
2736:
2718:
2713:
2703:
2698:
2656:
2644:
2632:
2604:
2591:
2586:
2556:
2519:
2514:
2452:
2447:
2393:
2338:
2290:
2276:
2224:
2211:
2180:
2113:
2102:
2075:
2065:
2060:
2006:
1961:
1956:
1857:
1821:
1753:
1743:
1732:
1716:
1668:
1651:
1627:
1579:
1567:
1519:
829:
752:
672:, loss of appetite, cough, and rash. Other severe side effects include
541:
386:
242:
3100:
3080:
3035:
3025:
3019:
2923:
2868:
2817:
2741:
2731:
2686:
2673:
2614:
2576:
2504:
2442:
2383:
2372:
2328:
2285:
2244:
2238:
2234:
2196:
2123:
2118:
2108:
2080:
2040:
2001:
1976:
1966:
1926:
1572:
1562:
1557:
1552:
1514:
732:
677:
665:
321:
266:
245:
to inactive metabolites. Two minor metabolites (M3 and M4) formed by
65:
824:
Bendamustine is a white, water-soluble microcrystalline powder with
30:
3009:
2973:
2913:
2681:
2619:
2399:
2295:
2267:
1946:
1783:
899:
760:
720:
684:
family of medication. It works by interfering with the function of
669:
366:
107:
975:
564:
1902:
1803:
1617:
1478:
922:
848:
719:
One combination for stage III/IV relapsed or refractory indolent
839:
After intravenous infusion it is extensively metabolised in the
1542:
1071:(69 ed.). British Medical Association. 2015. p. 579.
852:
736:
426:
246:
863:
Bendamustine was first made in 1963 by
Ozegowski and Krebs in
1373:
Bagchi S (August 2007). "Bendamustine for advanced sarcoma".
840:
555:
847:. More than 95% of the drug is bound to protein – primarily
451:
1217:"'Rediscovered' Lymphoma Drug Helps Double Survival: Study"
261:
40 min (bendamustine), 3 h (M3), 30 min (M4)
1407:
832:
causing intra-strand and inter-strand cross-links between
1119:
1091:
833:
689:
685:
1147:
1109:. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
759:. Notably, this drug has a low incidence of hair loss (
697:
World Health Organization's List of Essential Medicines
747:
Common adverse reactions are typical for the class of
3152:
1045:. The American Society of Health-System Pharmacists.
354:
680:is known to harm the baby. Bendamustine is in the
3176:
334:
309:
1287:
921:It is also being studied for the treatment of
3205:World Health Organization essential medicines
1436:
1192:Susman E (December 2012). Zaleznik DF (ed.).
1240:"Bendamustine: something old, something new"
755:, as well as immunosuppression, anemia, and
111:
1443:
1429:
1237:
1037:
1035:
1033:
1031:
1029:
1027:
1025:
1023:
1021:
488:
465:
394:
292:4--1-methylbenzimidazol-2-yl]butanoic acid
29:
1132:
1104:
1001:
414:
1141:
1069:British national formulary : BNF 69
763:) unlike most other chemotherapy drugs.
710:
676:and increased risk of infection. Use in
1214:
1018:
461:
374:
84:
3210:Science and technology in East Germany
3177:
1372:
1194:"New Combo Replaces CHOP for Lymphoma"
1191:
1113:
1085:
951:Therapeutic Goods Administration (TGA)
587:ClCCN(c2ccc1c(nc(n1C)CCCC(=O)O)c2)CCCl
479:
1424:
1127:. Geneva: World Health Organization.
1099:. Geneva: World Health Organization.
1049:from the original on 21 December 2016
434:
189:
102:
70:
1247:Cancer Chemotherapy and Pharmacology
1061:
149:
1712:ribonucleotide reductase inhibitors
1227:from the original on July 12, 2012.
325:
13:
1878:Ribonucleotide reductase inhibitor
1834:Ribonucleotide reductase inhibitor
957:from the original on 10 April 2023
742:
14:
3221:
1637:Dihydrofolate reductase inhibitor
176:
3162:
1290:Advanced Synthesis and Catalysis
1238:Tageja N, Nagi J (August 2010).
525:
519:
513:
1401:
1366:
1337:
1308:
1281:
1231:
819:
706:
612:Key:YTKUWDBFDASYHO-UHFFFAOYSA-N
1774:Thymidylate synthase inhibitor
1664:Thymidylate synthase inhibitor
1208:
1185:
1149:Lymphoma Study Group (GLSG)".
969:
939:
699:. It was originally made from
531:
507:
1:
1694:Adenosine deaminase inhibitor
1535:Block microtubule disassembly
1387:10.1016/S1470-2045(07)70225-5
932:
1221:U.S. News & World Report
1043:"Bendamustine Hydrochloride"
907:Food and Drug Administration
869:chronic lymphocytic leukemia
664:Common side effects include
647:chronic lymphocytic leukemia
637:, sold under the brand name
7:
1413:. 130 (supplement 1): 1838.
1215:Mundell EJ (June 3, 2012).
916:
902:received approval from the
10:
3226:
1137:. WHO/MHP/HPS/EML/2021.02.
858:
828:properties. It acts as an
766:
497:Chemical and physical data
3113:
2994:Omacetaxine mepesuccinate
2874:Ciltacabtagene autoleucel
2864:Brexucabtagene autoleucel
2810:
2761:
2541:
2534:
2470:
2424:
2357:
2314:
2151:
2136:
2016:
1986:
1911:
1896:
1867:
1763:
1683:
1626:
1609:
1598:
1534:
1487:
1468:
1259:10.1007/s00280-010-1317-x
1163:10.1080/10428190701361828
1121:World Health Organization
1093:World Health Organization
994:10.1007/s40268-012-0001-5
784:-dimethylacetamide (DMA).
729:progression-free survival
645:used in the treatment of
620:
595:
575:
553:
540:
501:
496:
477:
445:
425:
405:
385:
365:
345:
320:
300:
280:
275:
271:~50% urinary, ~25% fecal
265:
252:
236:
226:
212:
204:
166:
161:
136:
122:
92:
78:
60:
52:
42:
37:
28:
3046:Talimogene laherparepvec
2979:Nadofaragene firadenovec
2949:Lisocabtagene maraleucel
1898:Topoisomerase inhibitors
1817:DNA polymerase inhibitor
1302:10.1002/prac.19630200310
2849:Axicabtagene ciloleucel
1453:chemotherapeutic agents
1151:Leukemia & Lymphoma
643:chemotherapy medication
3031:Sitimagene ceradenovec
2929:Idecabtagene vicleucel
2494:Methyl aminolevulinate
1349:Cephalon press release
1320:Cephalon press release
893:non-Hodgkin's lymphoma
877:non-Hodgkin's lymphoma
731:when given along with
716:
655:non-Hodgkin's lymphoma
3200:Chloroethyl compounds
2505:Porphyrin derivatives
2201:Melphalan flufenamide
1848:Hypomethylating agent
1457:antineoplastic agents
714:
666:low blood cell counts
659:injection into a vein
2834:Asparagine depleters
2763:Receptor antagonists
2677:+abiraterone acetate
1375:The Lancet. Oncology
725:mantle cell lymphoma
131:Intravenous infusion
2884:Denileukin diftitox
2784:Retinoid X receptor
2484:Aminolevulinic acid
2306:Triethylenemelamine
2138:Crosslinking of DNA
1869:Deoxyribonucleotide
1808:+gimeracil/oteracil
757:low platelet counts
641:among others, is a
185:(Prescription only)
25:
3140:Never to phase III
1942:Etirinotecan pegol
717:
674:allergic reactions
21:
3195:Nitrogen mustards
3150:
3149:
3109:
3108:
3066:Tigilanol tiglate
2543:Enzyme inhibitors
2466:
2465:
2462:
2461:
2162:Nitrogen mustards
2132:
2131:
1892:
1891:
1594:
1593:
873:Hodgkin's disease
805:Recommendations:
749:nitrogen mustards
682:alkylating agents
668:, fever, nausea,
657:. It is given by
632:
631:
566:Interactive image
447:CompTox Dashboard
193:
180:
105:
16:Chemical compound
3217:
3167:
3166:
3165:
3158:
3071:Tisagenlecleucel
2828:Arsenic trioxide
2539:
2538:
2472:Photosensitizers
2263:Alkyl sulfonates
2177:Cyclophosphamide
2149:
2148:
2088:Anthracenediones
1909:
1908:
1883:Hydroxycarbamide
1624:
1623:
1607:
1606:
1485:
1484:
1445:
1438:
1431:
1422:
1421:
1415:
1414:
1405:
1399:
1398:
1370:
1364:
1363:
1361:
1360:
1351:. Archived from
1341:
1335:
1334:
1332:
1331:
1322:. Archived from
1312:
1306:
1305:
1296:(3–4): 178–186.
1285:
1279:
1278:
1244:
1235:
1229:
1228:
1212:
1206:
1205:
1200:. Archived from
1189:
1183:
1182:
1157:(7): 1299–1306.
1145:
1139:
1138:
1136:
1117:
1111:
1110:
1108:
1089:
1083:
1082:
1065:
1059:
1058:
1056:
1054:
1039:
1016:
1015:
1005:
982:Drugs in R&D
973:
967:
966:
964:
962:
953:. 21 June 2022.
943:
881:multiple myeloma
830:alkylating agent
701:nitrogen mustard
651:multiple myeloma
628:
627:
568:
548:
533:
527:
521:
515:
509:
492:
481:
470:
469:
455:
453:
438:
418:
398:
378:
358:
338:
328:
327:
313:
257:
191:
188:
178:
175:
153:
115:
104:
101:
88:
74:
33:
26:
24:
20:
3225:
3224:
3220:
3219:
3218:
3216:
3215:
3214:
3190:Organochlorides
3175:
3174:
3173:
3163:
3161:
3153:
3151:
3146:
3145:
3130:Clinical trials
3105:
2811:Other/ungrouped
2806:
2757:
2530:
2510:Porfimer sodium
2458:
2420:
2353:
2310:
2140:
2128:
2012:
1982:
1900:
1888:
1863:
1759:
1679:
1615:
1613:antimetabolites
1611:
1610:DNA precursors/
1602:
1600:DNA replication
1590:
1530:
1500:Vinca alkaloids
1476:
1464:
1449:
1419:
1418:
1406:
1402:
1371:
1367:
1358:
1356:
1343:
1342:
1338:
1329:
1327:
1314:
1313:
1309:
1286:
1282:
1242:
1236:
1232:
1213:
1209:
1190:
1186:
1146:
1142:
1118:
1114:
1090:
1086:
1079:
1067:
1066:
1062:
1052:
1050:
1041:
1040:
1019:
974:
970:
960:
958:
945:
944:
940:
935:
919:
898:In March 2008,
861:
845:cytochrome p450
822:
769:
745:
743:Adverse effects
709:
623:
621:
616:
613:
608:
603:
602:
591:
588:
583:
582:
571:
546:
536:
530:
524:
518:
512:
473:
449:
441:
421:
401:
381:
361:
341:
324:
316:
296:
293:
288:
287:
255:
228:Protein binding
214:Bioavailability
206:Pharmacokinetic
200:
157:
125:
118:
48:Treanda, others
17:
12:
11:
5:
3223:
3213:
3212:
3207:
3202:
3197:
3192:
3187:
3185:Benzimidazoles
3172:
3171:
3148:
3147:
3144:
3143:
3142:
3141:
3138:
3127:
3121:
3115:
3114:
3111:
3110:
3107:
3106:
3104:
3103:
3098:
3093:
3088:
3083:
3078:
3073:
3068:
3063:
3058:
3053:
3048:
3043:
3038:
3033:
3028:
3023:
3017:
3006:
3001:
2996:
2991:
2986:
2981:
2976:
2971:
2966:
2961:
2956:
2951:
2946:
2941:
2936:
2931:
2926:
2921:
2916:
2911:
2906:
2901:
2896:
2891:
2886:
2881:
2876:
2871:
2866:
2861:
2856:
2851:
2846:
2830:
2825:
2820:
2814:
2812:
2808:
2807:
2805:
2804:
2792:
2780:
2767:
2765:
2759:
2758:
2756:
2755:
2749:
2744:
2739:
2734:
2722:
2716:
2711:
2706:
2701:
2690:
2684:
2679:
2671:
2664:PARP inhibitor
2660:
2648:
2636:
2624:
2623:
2622:
2617:
2612:
2607:
2595:
2589:
2584:
2579:
2574:
2560:
2547:
2545:
2536:
2532:
2531:
2529:
2528:
2522:
2517:
2512:
2501:
2496:
2491:
2486:
2480:
2478:
2468:
2467:
2464:
2463:
2460:
2459:
2457:
2456:
2450:
2445:
2440:
2430:
2428:
2422:
2421:
2419:
2418:
2412:
2407:
2396:
2391:
2386:
2381:
2369:
2363:
2361:
2355:
2354:
2352:
2351:
2346:
2341:
2336:
2331:
2326:
2320:
2318:
2316:Platinum-based
2312:
2311:
2309:
2308:
2303:
2298:
2293:
2281:
2280:
2274:
2258:
2257:
2252:
2247:
2242:
2232:
2227:
2215:
2214:
2209:
2204:
2194:
2189:
2183:
2174:
2169:
2157:
2155:
2146:
2134:
2133:
2130:
2129:
2127:
2126:
2121:
2116:
2111:
2106:
2100:
2095:
2084:
2078:
2073:
2068:
2063:
2058:
2053:
2043:
2038:
2031:Anthracyclines
2026:
2024:
2014:
2013:
2011:
2010:
2004:
1992:
1990:
1984:
1983:
1981:
1980:
1974:
1969:
1964:
1959:
1954:
1949:
1944:
1939:
1934:
1929:
1917:
1915:
1906:
1894:
1893:
1890:
1889:
1887:
1886:
1873:
1871:
1865:
1864:
1862:
1861:
1855:
1843:
1842:
1829:
1828:
1812:
1811:
1801:
1796:
1791:
1786:
1781:
1769:
1767:
1761:
1760:
1758:
1757:
1751:
1749:Mercaptopurine
1740:
1735:
1730:
1724:
1719:
1703:
1702:
1689:
1687:
1681:
1680:
1678:
1677:
1671:
1660:
1654:
1649:
1644:
1632:
1630:
1621:
1604:
1596:
1595:
1592:
1591:
1589:
1588:
1576:
1570:
1565:
1560:
1555:
1550:
1538:
1536:
1532:
1531:
1529:
1528:
1522:
1517:
1512:
1507:
1495:
1493:
1482:
1466:
1465:
1451:Intracellular
1448:
1447:
1440:
1433:
1425:
1417:
1416:
1400:
1365:
1336:
1307:
1280:
1253:(3): 413–423.
1230:
1207:
1204:on 2014-09-11.
1184:
1140:
1112:
1084:
1077:
1060:
1017:
968:
937:
936:
934:
931:
927:AL amyloidosis
918:
915:
860:
857:
821:
818:
817:
816:
813:
810:
803:
802:
794:
793:
786:
785:
768:
765:
744:
741:
708:
705:
630:
629:
618:
617:
615:
614:
611:
609:
606:
598:
597:
596:
593:
592:
590:
589:
586:
578:
577:
576:
573:
572:
570:
569:
561:
559:
551:
550:
544:
538:
537:
534:
528:
522:
516:
510:
505:
499:
498:
494:
493:
483:
475:
474:
472:
471:
458:
456:
443:
442:
440:
439:
431:
429:
423:
422:
420:
419:
411:
409:
403:
402:
400:
399:
391:
389:
383:
382:
380:
379:
371:
369:
363:
362:
360:
359:
351:
349:
343:
342:
340:
339:
331:
329:
318:
317:
315:
314:
306:
304:
298:
297:
295:
294:
291:
283:
282:
281:
278:
277:
273:
272:
269:
263:
262:
259:
250:
249:
240:
234:
233:
230:
224:
223:
216:
210:
209:
202:
201:
199:
198:
186:
172:
170:
164:
163:
159:
158:
156:
155:
142:
140:
134:
133:
128:
126:administration
120:
119:
117:
116:
98:
96:
90:
89:
82:
76:
75:
68:
58:
57:
54:
50:
49:
46:
40:
39:
35:
34:
15:
9:
6:
4:
3:
2:
3222:
3211:
3208:
3206:
3203:
3201:
3198:
3196:
3193:
3191:
3188:
3186:
3183:
3182:
3180:
3170:
3160:
3159:
3156:
3139:
3137:
3134:
3133:
3131:
3128:
3125:
3122:
3120:
3117:
3116:
3112:
3102:
3099:
3097:
3094:
3092:
3089:
3087:
3084:
3082:
3079:
3077:
3074:
3072:
3069:
3067:
3064:
3062:
3059:
3057:
3054:
3052:
3049:
3047:
3044:
3042:
3039:
3037:
3034:
3032:
3029:
3027:
3024:
3021:
3018:
3016:
3012:
3011:
3007:
3005:
3004:Tabelecleucel
3002:
3000:
2997:
2995:
2992:
2990:
2987:
2985:
2982:
2980:
2977:
2975:
2972:
2970:
2967:
2965:
2964:Lurbinectedin
2962:
2960:
2957:
2955:
2952:
2950:
2947:
2945:
2942:
2940:
2937:
2935:
2932:
2930:
2927:
2925:
2922:
2920:
2917:
2915:
2912:
2910:
2907:
2905:
2902:
2900:
2897:
2895:
2892:
2890:
2887:
2885:
2882:
2880:
2877:
2875:
2872:
2870:
2867:
2865:
2862:
2860:
2857:
2855:
2852:
2850:
2847:
2844:
2840:
2836:
2835:
2831:
2829:
2826:
2824:
2821:
2819:
2816:
2815:
2813:
2809:
2802:
2798:
2797:
2793:
2790:
2786:
2785:
2781:
2778:
2774:
2773:
2769:
2768:
2766:
2764:
2760:
2753:
2750:
2748:
2745:
2743:
2740:
2738:
2735:
2733:
2729:
2727:
2723:
2720:
2717:
2715:
2712:
2710:
2707:
2705:
2702:
2700:
2696:
2695:
2691:
2688:
2685:
2683:
2680:
2678:
2675:
2672:
2670:
2666:
2665:
2661:
2658:
2654:
2653:
2649:
2646:
2642:
2641:
2637:
2634:
2630:
2629:
2625:
2621:
2618:
2616:
2613:
2611:
2608:
2606:
2603:
2602:
2601:
2600:
2596:
2593:
2590:
2588:
2585:
2583:
2580:
2578:
2575:
2573:
2569:
2568:
2565:
2561:
2558:
2554:
2553:
2549:
2548:
2546:
2544:
2540:
2537:
2533:
2526:
2523:
2521:
2518:
2516:
2513:
2511:
2507:
2506:
2502:
2500:
2497:
2495:
2492:
2490:
2487:
2485:
2482:
2481:
2479:
2477:
2473:
2469:
2454:
2451:
2449:
2446:
2444:
2441:
2439:
2435:
2432:
2431:
2429:
2427:
2426:Intercalation
2423:
2416:
2413:
2411:
2408:
2406:
2402:
2401:
2397:
2395:
2392:
2390:
2387:
2385:
2382:
2379:
2375:
2374:
2370:
2368:
2365:
2364:
2362:
2360:
2356:
2350:
2347:
2345:
2342:
2340:
2337:
2335:
2334:Dicycloplatin
2332:
2330:
2327:
2325:
2322:
2321:
2319:
2317:
2313:
2307:
2304:
2302:
2299:
2297:
2294:
2292:
2289:
2287:
2283:
2282:
2278:
2275:
2273:
2269:
2266:
2264:
2260:
2259:
2256:
2253:
2251:
2248:
2246:
2243:
2240:
2236:
2233:
2231:
2228:
2226:
2223:
2221:
2217:
2216:
2213:
2210:
2208:
2207:Prednimustine
2205:
2202:
2198:
2195:
2193:
2190:
2187:
2184:
2182:
2178:
2175:
2173:
2170:
2168:
2165:
2163:
2159:
2158:
2156:
2154:
2150:
2147:
2144:
2139:
2135:
2125:
2122:
2120:
2117:
2115:
2112:
2110:
2107:
2104:
2101:
2099:
2096:
2094:
2090:
2089:
2085:
2082:
2079:
2077:
2074:
2072:
2069:
2067:
2064:
2062:
2059:
2057:
2054:
2051:
2047:
2044:
2042:
2039:
2037:
2033:
2032:
2028:
2027:
2025:
2023:
2022:Intercalation
2019:
2015:
2008:
2005:
2003:
1999:
1998:
1994:
1993:
1991:
1989:
1985:
1978:
1975:
1973:
1970:
1968:
1965:
1963:
1960:
1958:
1955:
1953:
1950:
1948:
1945:
1943:
1940:
1938:
1935:
1933:
1930:
1928:
1924:
1923:
1919:
1918:
1916:
1914:
1910:
1907:
1904:
1899:
1895:
1884:
1880:
1879:
1875:
1874:
1872:
1870:
1866:
1859:
1856:
1854:
1850:
1849:
1845:
1844:
1840:
1836:
1835:
1831:
1830:
1826:
1825:+daunorubicin
1823:
1819:
1818:
1814:
1813:
1809:
1805:
1802:
1800:
1797:
1795:
1792:
1790:
1789:Doxifluridine
1787:
1785:
1782:
1780:
1776:
1775:
1771:
1770:
1768:
1766:
1762:
1755:
1752:
1750:
1746:
1745:
1741:
1739:
1738:Rabacfosadine
1736:
1734:
1731:
1728:
1725:
1723:
1720:
1718:
1714:
1713:
1709:
1705:
1704:
1700:
1696:
1695:
1691:
1690:
1688:
1686:
1682:
1675:
1672:
1670:
1666:
1665:
1661:
1658:
1655:
1653:
1650:
1648:
1645:
1643:
1639:
1638:
1634:
1633:
1631:
1629:
1625:
1622:
1619:
1614:
1608:
1605:
1601:
1597:
1586:
1582:
1581:
1577:
1574:
1571:
1569:
1566:
1564:
1561:
1559:
1556:
1554:
1551:
1549:
1545:
1544:
1540:
1539:
1537:
1533:
1526:
1523:
1521:
1518:
1516:
1513:
1511:
1508:
1506:
1502:
1501:
1497:
1496:
1494:
1491:
1486:
1483:
1480:
1475:
1471:
1467:
1462:
1458:
1454:
1446:
1441:
1439:
1434:
1432:
1427:
1426:
1423:
1412:
1404:
1396:
1392:
1388:
1384:
1380:
1376:
1369:
1355:on 2008-12-07
1354:
1350:
1346:
1340:
1326:on 2008-04-21
1325:
1321:
1317:
1311:
1303:
1299:
1295:
1291:
1284:
1276:
1272:
1268:
1264:
1260:
1256:
1252:
1248:
1241:
1234:
1226:
1222:
1218:
1211:
1203:
1199:
1195:
1188:
1180:
1176:
1172:
1168:
1164:
1160:
1156:
1152:
1144:
1135:
1130:
1126:
1122:
1116:
1107:
1102:
1098:
1094:
1088:
1080:
1078:9780857111562
1074:
1070:
1064:
1048:
1044:
1038:
1036:
1034:
1032:
1030:
1028:
1026:
1024:
1022:
1013:
1009:
1004:
999:
995:
991:
987:
983:
979:
972:
956:
952:
948:
942:
938:
930:
928:
924:
914:
910:
908:
905:
904:United States
901:
896:
894:
888:
886:
882:
878:
874:
870:
866:
856:
854:
850:
846:
842:
837:
835:
831:
827:
814:
811:
808:
807:
806:
799:
798:
797:
791:
790:
789:
783:
779:
774:
773:
772:
764:
762:
758:
754:
750:
740:
738:
734:
730:
726:
722:
713:
704:
702:
698:
693:
691:
687:
683:
679:
675:
671:
667:
662:
660:
656:
652:
648:
644:
640:
636:
626:
619:
610:
605:
604:
601:
594:
585:
584:
581:
574:
567:
563:
562:
560:
557:
552:
545:
543:
539:
506:
504:
500:
495:
491:
487:
484:
482:
480:ECHA InfoCard
476:
468:
464:
463:DTXSID2046888
460:
459:
457:
448:
444:
437:
433:
432:
430:
428:
424:
417:
413:
412:
410:
408:
404:
397:
393:
392:
390:
388:
384:
377:
373:
372:
370:
368:
364:
357:
353:
352:
350:
348:
344:
337:
333:
332:
330:
323:
319:
312:
308:
307:
305:
303:
299:
290:
289:
286:
279:
274:
270:
268:
264:
260:
258:
251:
248:
244:
241:
239:
235:
231:
229:
225:
221:
217:
215:
211:
207:
203:
197:
187:
184:
174:
173:
171:
169:
165:
160:
152:
147:
144:
143:
141:
139:
135:
132:
129:
127:
121:
114:
109:
100:
99:
97:
95:
91:
87:
83:
81:
77:
73:
69:
67:
63:
59:
55:
51:
47:
45:
41:
38:Clinical data
36:
32:
27:
19:
3051:Tazemetostat
3015:Alitretinoin
3008:
2919:Estramustine
2899:Elsamitrucin
2889:Eflornithine
2843:Pegaspargase
2839:Asparaginase
2832:
2801:Testolactone
2794:
2782:
2770:
2724:
2709:Panobinostat
2692:
2662:
2650:
2638:
2626:
2597:
2562:
2550:
2503:
2499:Padeliporfin
2438:Dactinomycin
2434:Streptomyces
2415:Temozolomide
2410:Mitozolomide
2398:
2389:Mitobronitol
2378:Procarbazine
2371:
2359:Nonclassical
2284:
2261:
2255:Streptozocin
2220:Nitrosoureas
2218:
2192:Chlorambucil
2186:Trofosfamide
2172:Chlormethine
2167:Bendamustine
2166:
2160:
2098:Mitoxantrone
2093:Losoxantrone
2086:
2046:Daunorubicin
2029:
1995:
1932:Camptothecin
1920:
1876:
1846:
1832:
1815:
1799:Fluorouracil
1779:Capecitabine
1772:
1742:
1706:
1692:
1662:
1657:Pralatrexate
1647:Methotrexate
1635:
1578:
1541:
1498:
1410:
1403:
1378:
1374:
1368:
1357:. Retrieved
1353:the original
1348:
1339:
1328:. Retrieved
1324:the original
1319:
1310:
1293:
1289:
1283:
1250:
1246:
1233:
1220:
1210:
1202:the original
1198:MedPageToday
1197:
1187:
1154:
1150:
1143:
1134:10665/345533
1124:
1115:
1106:10665/325771
1096:
1087:
1068:
1063:
1051:. Retrieved
988:(1): 17–28.
985:
981:
971:
959:. Retrieved
950:
941:
920:
911:
897:
889:
865:East Germany
862:
838:
823:
820:Pharmacology
804:
796:Assessment:
795:
788:Background:
787:
781:
777:
770:
746:
718:
707:Medical uses
694:
663:
638:
635:Bendamustine
634:
633:
622:
436:ChEMBL487253
254:Elimination
168:Legal status
162:Legal status
94:License data
23:Bendamustine
18:
3126:from market
3096:Vorasidenib
3076:Trabectedin
3061:Tiazofurine
3056:Tebentafusp
3041:Tagraxofusp
2999:Plitidepsin
2969:Mitoguazone
2909:Epacadostat
2879:Demecolcine
2823:Aflibercept
2796:Sex steroid
2669:Fuzuloparib
2610:Carfilzomib
2582:Palbociclib
2572:Abemaciclib
2525:Verteporfin
2489:Efaproxiral
2405:Dacarbazine
2367:Altretamine
2349:Satraplatin
2344:Oxaliplatin
2324:Carboplatin
2301:Triaziquone
2272:Mannosulfan
2250:Ranimustine
2230:Fotemustine
2071:Pirarubicin
2056:Doxorubicin
2050:+cytarabine
2036:Aclarubicin
1997:Podophyllum
1922:Camptotheca
1853:Azacitidine
1839:Gemcitabine
1794:Floxuridine
1727:Fludarabine
1722:Clofarabine
1708:Halogenated
1699:Pentostatin
1674:Raltitrexed
1642:Aminopterin
1585:Ixabepilone
1580:Epothilones
1548:Cabazitaxel
1525:Vinorelbine
1510:Vincristine
1505:Vinblastine
1490:microtubule
885:lung cancer
739:treatment.
549: g·mol
486:100.205.789
276:Identifiers
220:intravenous
80:MedlinePlus
53:Other names
44:Trade names
3179:Categories
3091:Verdinexor
3086:Venetoclax
2989:Oblimersen
2984:Navitoclax
2959:Lucanthone
2954:Lonidamine
2944:Lifileucel
2939:Ivosidenib
2934:Imetelstat
2904:Enasidenib
2894:Elesclomol
2859:Bexarotene
2854:Belzutifan
2789:Bexarotene
2777:Atrasentan
2752:Umbralisib
2747:Idelalisib
2737:Copanlisib
2719:Vorinostat
2714:Romidepsin
2704:Entinostat
2699:Belinostat
2657:Masoprocol
2645:Tiazofurin
2633:Anagrelide
2605:Bortezomib
2592:Seliciclib
2587:Ribociclib
2567:inhibitors
2557:Tipifarnib
2520:Temoporfin
2515:Talaporfin
2453:Plicamycin
2448:Mitomycins
2394:Pipobroman
2373:Hydrazines
2339:Nedaplatin
2291:Carboquone
2286:Aziridines
2277:Treosulfan
2225:Carmustine
2212:Uramustine
2181:Ifosfamide
2153:Alkylating
2114:Bisantrene
2103:Pixantrone
2076:Valrubicin
2066:Idarubicin
2061:Epirubicin
2007:Teniposide
1962:Lurtotecan
1957:Irinotecan
1858:Decitabine
1822:Cytarabine
1765:Pyrimidine
1754:Tioguanine
1744:Thiopurine
1733:Nelarabine
1717:Cladribine
1669:Pemetrexed
1652:Pemetrexed
1628:Folic acid
1568:Paclitaxel
1520:Vinflunine
1381:(8): 674.
1359:2008-11-03
1330:2008-03-23
1053:8 December
933:References
826:amphoteric
753:stomatitis
554:3D model (
542:Molar mass
416:9266D9P3PQ
387:ChemSpider
347:IUPHAR/BPS
311:16506-27-7
302:CAS Number
285:IUPAC name
243:Hydrolyzed
238:Metabolism
3136:Phase III
3124:Withdrawn
3101:Vosaroxin
3081:Veliparib
3036:Sotorasib
3026:Selinexor
3020:Tretinoin
3010:Retinoids
2924:Glasdegib
2869:Celecoxib
2818:Adagrasib
2742:Duvelisib
2732:Alpelisib
2687:Rucaparib
2674:Niraparib
2615:Oprozomib
2577:Alvocidib
2443:Bleomycin
2400:Triazenes
2384:Etoglucid
2329:Cisplatin
2245:Nimustine
2239:Semustine
2235:Lomustine
2197:Melphalan
2124:Menogaril
2119:Crisnatol
2109:Amsacrine
2081:Zorubicin
2041:Amrubicin
2002:Etoposide
1977:Topotecan
1972:Silatecan
1967:Rubitecan
1952:Gimatecan
1937:Cositecan
1927:Belotecan
1603:inhibitor
1573:Tesetaxel
1563:Ortataxel
1558:Larotaxel
1553:Docetaxel
1515:Vindesine
801:patients.
733:rituximab
721:lymphomas
678:pregnancy
267:Excretion
256:half-life
124:Routes of
72:Monograph
66:Drugs.com
3169:Medicine
2974:Mitotane
2914:Eribulin
2682:Olaparib
2620:Ixazomib
2296:Thiotepa
2268:Busulfan
1947:Exatecan
1784:Carmofur
1492:assembly
1455: /
1395:17726779
1275:25605764
1267:20376452
1225:Archived
1171:17613757
1123:(2021).
1095:(2019).
1047:Archived
1012:23322528
961:10 April
955:Archived
917:Research
900:Cephalon
761:alopecia
670:diarrhea
625:(verify)
367:DrugBank
138:ATC code
108:DailyMed
1903:S phase
1804:Tegafur
1618:S phase
1543:Taxanes
1479:M phase
1179:2381354
1003:3627029
923:sarcoma
859:History
853:kidneys
849:albumin
836:bases.
767:Warning
649:(CLL),
639:Treanda
503:Formula
376:DB06769
322:PubChem
154:)
148: (
146:L01AA09
113:Treanda
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86:a608034
56:SDX-105
3155:Portal
3119:WHO-EM
2728:(Pi3K)
1685:Purine
1488:Block
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1010:
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737:R-CHOP
653:, and
580:SMILES
547:358.26
427:ChEMBL
247:CYP1A2
232:94–96%
196:â„ž-only
194:
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106:
2640:IMPDI
2535:Other
1411:Blood
1271:S2CID
1243:(PDF)
1175:S2CID
841:liver
600:InChI
556:JSmol
396:59069
336:65628
222:only)
2726:PIKI
2694:HDAC
2143:CCNS
1391:PMID
1263:PMID
1167:PMID
1073:ISBN
1055:2016
1008:PMID
963:2023
883:and
723:and
688:and
407:UNII
356:7478
218:NA (
208:data
62:AHFS
2772:ERA
2628:PhI
2599:PrI
2564:CDK
2476:PDT
1474:MIs
1470:SPs
1461:L01
1383:doi
1298:doi
1255:doi
1159:doi
1129:hdl
1101:hdl
998:PMC
990:doi
843:by
834:DNA
690:RNA
686:DNA
452:EPA
326:CID
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