298:
286:
373:
145:
40:
318:
350:). Villous adenomas have been demonstrated to contain malignant portions in about 15–25% of cases, approaching 40% in those over 4 cm in diameter. Colonic resection may be required for large lesions. These can also lead to secretory diarrhea with large volume liquid stools with few formed elements. They are commonly described as secreting large amounts of mucus, resulting in
297:
390:
are characterized by (1) basal dilation of the crypts, (2) basal crypt serration, (3) crypts that run horizontal to the basement membrane (horizontal crypts), and (4) crypt branching. The most common of these features is basal dilation of the crypts.
285:
307:
in a tubulovillous adenoma, in this case seen mainly as loss of cell polarity, as cells become more plump and haphazard than the elongated and parallel nuclei of surrounding low-grade dysplasia.
551:
795:
1026:
902:
291:
Normal (left) versus dysplastic (large at right) colonic crypts, the latter conferring a diagnosis of a tubular and/or villous adenoma.
1051:
354:
in patients. On endoscopy, a "cauliflower' like mass is described due to villi stretching. Being an adenoma, the mass is covered in
788:
1276:
1136:
586:
821:
1346:
1325:
1281:
781:
888:
1184:
695:"Serrated polyps of the large intestine: Current understanding of diagnosis, pathogenesis, and clinical management"
17:
1286:
1089:
1046:
1017:
997:
148:
Incidences and malignancy risks of various types of colorectal polyps. Adenomatous types are grouped at top.
1315:
989:
812:
1255:
1031:
1007:
1271:
1012:
993:
866:
1179:
1108:
804:
125:
1361:
1356:
1351:
1131:
985:
387:
377:
367:
355:
220:
1320:
1069:
838:
523:
Srivastava, S; Verma, M; Henson, D. E. (2001). "Biomarkers for early detection of colon cancer".
81:
1161:
949:
911:
1021:
674:
1166:
742:
Levine JS, Ahnen DJ (December 2006). "Clinical practice. Adenomatous polyps of the colon".
372:
144:
8:
253:
1226:
1208:
1148:
977:
719:
694:
647:
614:
500:
475:
451:
426:
71:
1293:
1245:
1236:
959:
861:
830:
759:
724:
652:
634:
592:
582:
532:
505:
456:
400:
93:
86:
59:
1094:
968:
883:
871:
751:
714:
706:
642:
626:
495:
487:
446:
438:
405:
133:
64:
936:
919:
325:
693:
Rosty, C; Hewett, D. G.; Brown, I. S.; Leggett, B. A.; Whitehall, V. L. (2013).
1250:
1213:
1143:
1041:
981:
924:
853:
843:
442:
164:
710:
491:
1340:
1194:
876:
773:
638:
596:
476:"ABC of colorectal diseases. Colorectal neoplasia—I: Benign colonic tumours"
1156:
763:
728:
656:
536:
381:
351:
332:
129:
51:
630:
509:
460:
1221:
1174:
1117:
1061:
755:
108:
98:
50:(tubular component – left of image, villous component – right of image).
39:
1307:
556:
321:
236:
Crypts that run horizontal to the basement membrane (horizontal crypts)
1203:
1126:
944:
347:
343:
276:
272:
615:"Colorectal Cancer: Epidemiology, Risk Factors, and Health Services"
1266:
339:
317:
121:
328:
124:
of the colon and the rectum. It is a precursor lesion of the
1263:
613:
Amersi, Farin; Agustin, Michelle; Ko, Clifford Y (2005).
692:
581:. Lyon: International Agency for Research on Cancer.
579:
WHO classification of tumours of the digestive system
522:
608:
606:
424:
271:are considered to have a higher risk of becoming
1338:
603:
427:"Early diagnosis of colorectal cancer: A review"
612:
803:
473:
789:
549:
741:
735:
668:
666:
425:Hardcastle, J. D.; Armitage, N. C. (1984).
361:
181:Over 75% of volume has tubular appearance.
796:
782:
38:
1052:Hereditary nonpolyposis colorectal cancer
718:
646:
499:
450:
672:
663:
431:Journal of the Royal Society of Medicine
371:
316:
259:
143:
1277:Intraductal papillary mucinous neoplasm
474:Schofield, P. F.; Jones, D. J. (1992).
14:
1339:
576:
777:
572:
570:
568:
1326:Desmoplastic small round cell tumor
619:Clinics in Colon and Rectal Surgery
562:Last full review/revision June 2019
139:
24:
1027:Polymerase proofreading-associated
565:
312:
247:
161:Risk of containing malignant cells
25:
1373:
889:Hereditary diffuse gastric cancer
1185:Nodular regenerative hyperplasia
552:"Polyps of the Colon and Rectum"
296:
284:
1287:Solid pseudopapillary neoplasm
1090:Gastrointestinal stromal tumor
1047:Familial adenomatous polyposis
686:
543:
516:
467:
418:
13:
1:
1095:Krukenberg tumor (metastatic)
411:
76:Asymptomatic, rectal bleeding
1316:Primary peritoneal carcinoma
990:traditional serrated adenoma
230:Basal dilation of the crypts
7:
1256:Pancreatic ductal carcinoma
699:Journal of Gastroenterology
675:"Villous Adenoma Follow-up"
480:BMJ (Clinical Research Ed.)
394:
256:, these display dysplasia.
10:
1378:
1347:Digestive system neoplasia
1272:Serous microcystic adenoma
867:Signet ring cell carcinoma
805:Digestive system neoplasia
443:10.1177/014107688407700812
365:
132:). They often manifest as
1306:
1235:
1193:
1180:Focal nodular hyperplasia
1116:
1107:
1082:
1060:
958:
935:
910:
901:
852:
829:
820:
811:
711:10.1007/s00535-012-0720-y
492:10.1136/bmj.304.6840.1498
388:Sessile serrated adenomas
356:columnar epithelial cells
279:) than tubular adenomas.
126:colorectal adenocarcinoma
104:
92:
80:
70:
58:
46:
37:
32:
1282:Mucinous cystic neoplasm
1132:Hepatocellular carcinoma
986:sessile serrated adenoma
525:Clinical Cancer Research
378:sessile serrated adenoma
368:Sessile serrated adenoma
362:Sessile serrated adenoma
221:Sessile serrated adenoma
1321:Peritoneal mesothelioma
1070:Squamous cell carcinoma
839:Squamous cell carcinoma
1162:Hepatocellular adenoma
950:Pseudomyxoma peritonei
577:Bosman, F. T. (2010).
384:
335:
186:Tubulovillous adenoma
149:
683:Updated: Oct 24, 2016
631:10.1055/s-2005-916274
375:
320:
265:Tubulovillous adenoma
260:Tubulovillous adenoma
233:Basal crypt serration
147:
48:Tubulovillous adenoma
1167:Cavernous hemangioma
1018:Familial adenomatous
1005:Polyposis syndromes:
756:10.1056/NEJMcp063038
305:high-grade dysplasia
254:hyperplastic polyps
154:
153:Colorectal adenoma
1227:Gallbladder cancer
1209:Cholangiocarcinoma
1149:Liver angiosarcoma
1083:Upper and/or lower
1032:Serrated polyposis
550:Minhhuyen Nguyen.
486:(6840): 1498–500.
385:
336:
303:Histopathology of
152:
150:
118:colorectal adenoma
33:Colorectal adenoma
1334:
1333:
1302:
1301:
1294:Pancreatoblastoma
1246:exocrine pancreas
1103:
1102:
1078:
1077:
897:
896:
862:Gastric carcinoma
588:978-92-832-2432-7
401:Colorectal cancer
331:villous adenoma.
245:
244:
215:Over 75% villous
134:colorectal polyps
114:
113:
94:Diagnostic method
87:Colorectal cancer
27:Medical condition
16:(Redirected from
1369:
1114:
1113:
1013:MUTYH-associated
998:Cronkhite–Canada
969:Colorectal polyp
908:
907:
884:Linitis plastica
872:Gastric lymphoma
827:
826:
818:
817:
798:
791:
784:
775:
774:
768:
767:
739:
733:
732:
722:
690:
684:
682:
670:
661:
660:
650:
610:
601:
600:
574:
563:
561:
547:
541:
540:
520:
514:
513:
503:
471:
465:
464:
454:
422:
406:Colorectal polyp
376:Micrograph of a
300:
288:
239:Crypt branching.
203:Villous adenoma
172:Tubular adenoma
155:
151:
140:Comparison table
65:Gastroenterology
42:
30:
29:
21:
1377:
1376:
1372:
1371:
1370:
1368:
1367:
1366:
1362:Rectal diseases
1357:Large intestine
1352:Gross pathology
1337:
1336:
1335:
1330:
1298:
1231:
1189:
1099:
1074:
1056:
954:
931:
920:Duodenal cancer
912:Small intestine
893:
848:
807:
802:
772:
771:
744:N. Engl. J. Med
740:
736:
691:
687:
671:
664:
611:
604:
589:
575:
566:
548:
544:
521:
517:
472:
468:
423:
419:
414:
397:
370:
364:
315:
313:Villous adenoma
308:
301:
292:
289:
262:
252:In contrast to
250:
248:Tubular adenoma
198:25–75% villous
142:
122:glandular tumor
28:
23:
22:
18:Tubular adenoma
15:
12:
11:
5:
1375:
1365:
1364:
1359:
1354:
1349:
1332:
1331:
1329:
1328:
1323:
1318:
1312:
1310:
1304:
1303:
1300:
1299:
1297:
1296:
1290:
1289:
1284:
1279:
1274:
1259:
1258:
1253:
1251:Adenocarcinoma
1241:
1239:
1233:
1232:
1230:
1229:
1217:
1216:
1214:Klatskin tumor
1211:
1199:
1197:
1191:
1190:
1188:
1187:
1182:
1170:
1169:
1164:
1152:
1151:
1146:
1144:Hepatoblastoma
1141:
1140:
1139:
1122:
1120:
1111:
1105:
1104:
1101:
1100:
1098:
1097:
1092:
1086:
1084:
1080:
1079:
1076:
1075:
1073:
1072:
1066:
1064:
1058:
1057:
1055:
1054:
1049:
1044:
1042:Adenocarcinoma
1035:
1034:
1029:
1024:
1015:
1010:
1001:
1000:
964:
962:
956:
955:
953:
952:
947:
941:
939:
933:
932:
930:
929:
928:
927:
925:Adenocarcinoma
916:
914:
905:
899:
898:
895:
894:
892:
891:
886:
881:
880:
879:
869:
864:
858:
856:
850:
849:
847:
846:
844:Adenocarcinoma
841:
835:
833:
824:
815:
809:
808:
801:
800:
793:
786:
778:
770:
769:
750:(24): 2551–7.
734:
705:(3): 287–302.
685:
673:Alnoor Ramji.
662:
625:(3): 133–140.
602:
587:
564:
542:
531:(5): 1118–26.
515:
466:
416:
415:
413:
410:
409:
408:
403:
396:
393:
366:Main article:
363:
360:
314:
311:
310:
309:
302:
295:
293:
290:
283:
261:
258:
249:
246:
243:
242:
241:
240:
237:
234:
231:
226:
224:
217:
216:
213:
204:
200:
199:
196:
187:
183:
182:
179:
178:at 1.5 cm
173:
169:
168:
165:Histopathology
162:
159:
141:
138:
112:
111:
106:
102:
101:
96:
90:
89:
84:
78:
77:
74:
68:
67:
62:
56:
55:
44:
43:
35:
34:
26:
9:
6:
4:
3:
2:
1374:
1363:
1360:
1358:
1355:
1353:
1350:
1348:
1345:
1344:
1342:
1327:
1324:
1322:
1319:
1317:
1314:
1313:
1311:
1309:
1305:
1295:
1292:
1291:
1288:
1285:
1283:
1280:
1278:
1275:
1273:
1269:
1268:
1265:
1261:
1260:
1257:
1254:
1252:
1249:
1247:
1243:
1242:
1240:
1238:
1234:
1228:
1225:
1223:
1219:
1218:
1215:
1212:
1210:
1207:
1205:
1201:
1200:
1198:
1196:
1195:Biliary tract
1192:
1186:
1183:
1181:
1178:
1176:
1172:
1171:
1168:
1165:
1163:
1160:
1158:
1154:
1153:
1150:
1147:
1145:
1142:
1138:
1137:Fibrolamellar
1135:
1134:
1133:
1130:
1128:
1124:
1123:
1121:
1119:
1115:
1112:
1110:
1106:
1096:
1093:
1091:
1088:
1087:
1085:
1081:
1071:
1068:
1067:
1065:
1063:
1059:
1053:
1050:
1048:
1045:
1043:
1040:
1037:
1036:
1033:
1030:
1028:
1025:
1023:
1019:
1016:
1014:
1011:
1009:
1006:
1003:
1002:
999:
995:
994:Peutz–Jeghers
991:
987:
983:
979:
975:
972:
970:
966:
965:
963:
961:
957:
951:
948:
946:
943:
942:
940:
938:
934:
926:
923:
922:
921:
918:
917:
915:
913:
909:
906:
904:
900:
890:
887:
885:
882:
878:
877:MALT lymphoma
875:
874:
873:
870:
868:
865:
863:
860:
859:
857:
855:
851:
845:
842:
840:
837:
836:
834:
832:
828:
825:
823:
819:
816:
814:
810:
806:
799:
794:
792:
787:
785:
780:
779:
776:
765:
761:
757:
753:
749:
745:
738:
730:
726:
721:
716:
712:
708:
704:
700:
696:
689:
680:
676:
669:
667:
658:
654:
649:
644:
640:
636:
632:
628:
624:
620:
616:
609:
607:
598:
594:
590:
584:
580:
573:
571:
569:
559:
558:
553:
546:
538:
534:
530:
526:
519:
511:
507:
502:
497:
493:
489:
485:
481:
477:
470:
462:
458:
453:
448:
444:
440:
436:
432:
428:
421:
417:
407:
404:
402:
399:
398:
392:
389:
383:
382:H&E stain
379:
374:
369:
359:
357:
353:
349:
345:
341:
334:
333:H&E stain
330:
327:
323:
319:
306:
299:
294:
287:
282:
281:
280:
278:
274:
270:
266:
257:
255:
238:
235:
232:
229:
228:
227:
225:
222:
219:
218:
214:
212:
208:
205:
202:
201:
197:
195:
191:
188:
185:
184:
180:
177:
174:
171:
170:
166:
163:
160:
157:
156:
146:
137:
135:
131:
127:
123:
119:
110:
107:
103:
100:
97:
95:
91:
88:
85:
83:
82:Complications
79:
75:
73:
69:
66:
63:
61:
57:
53:
52:H&E stain
49:
45:
41:
36:
31:
19:
1262:
1244:
1220:
1202:
1173:
1155:
1125:
1038:
1004:
978:hyperplastic
973:
967:
960:Colon/rectum
747:
743:
737:
702:
698:
688:
678:
622:
618:
578:
555:
545:
528:
524:
518:
483:
479:
469:
437:(8): 673–6.
434:
430:
420:
386:
352:hypokalaemia
337:
304:
268:
264:
263:
251:
210:
206:
193:
189:
175:
130:colon cancer
120:is a benign
117:
115:
47:
1222:gallbladder
1175:hyperplasia
342:may become
167:definition
109:Polypectomy
99:Colonoscopy
1341:Categories
1308:Peritoneum
557:MSD Manual
412:References
322:Micrograph
1267:neoplasms
1204:bile duct
1127:malignant
1109:Accessory
1039:Neoplasm:
1022:Gardner's
945:Carcinoid
831:Esophagus
639:1531-0043
597:688585784
348:cancerous
344:malignant
277:cancerous
273:malignant
105:Treatment
60:Specialty
1237:Pancreas
1008:Juvenile
982:juvenile
937:Appendix
813:GI tract
764:17167138
729:23208018
679:Medscape
657:20011296
537:11350874
395:See also
340:adenomas
72:Symptoms
974:adenoma
854:Stomach
720:3698429
648:2780097
510:1319254
501:1882234
461:6384511
452:1440108
1264:cystic
1157:benign
762:
727:
717:
655:
645:
637:
595:
585:
535:
508:
498:
459:
449:
338:These
329:rectal
223:(SSA)
1118:Liver
903:Lower
822:Upper
324:of a
1062:Anus
760:PMID
725:PMID
653:PMID
635:ISSN
593:OCLC
583:ISBN
533:PMID
506:PMID
457:PMID
326:colo
158:Type
116:The
752:doi
748:355
715:PMC
707:doi
643:PMC
627:doi
496:PMC
488:doi
484:304
447:PMC
439:doi
269:TVA
211:40%
209:to
207:15%
194:25%
192:to
190:20%
1343::
1270::
996:,
992:,
988:,
984:,
980:,
976:,
758:.
746:.
723:.
713:.
703:48
701:.
697:.
677:.
665:^
651:.
641:.
633:.
623:18
621:.
617:.
605:^
591:.
567:^
554:.
527:.
504:.
494:.
482:.
478:.
455:.
445:.
435:77
433:.
429:.
380:.
358:.
267:,
176:2%
136:.
1248::
1224::
1206::
1177::
1159::
1129::
1020:/
971::
797:e
790:t
783:v
766:.
754::
731:.
709::
681:.
659:.
629::
599:.
560:.
539:.
529:7
512:.
490::
463:.
441::
346:(
275:(
128:(
54:.
20:)
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