561:
40:
31:
1196:. However, the threshold concentration of allopregnanolone to inhibit L-VGCCs was determined to be 3 μM (3,000 nM), which is far greater than the concentration of 5 nM that has been estimated to be naturally produced in the human brain. Thus, inhibition of L-VGCCs is unlikely of any actual significance in the effects of endogenous allopregnanolone. Also, allopregnanolone, along with several other neurosteroids, has been found to activate the
14848:
2303:
1549:
The efficacy of brexanolone was shown in two clinical studies of participants who received a 60-hour continuous intravenous infusion of brexanolone or placebo and were then followed for four weeks. The FDA approved allopregnanolone based on evidence from three clinical trials, conducted in the United
1725:, allopregnanolone has been shown to reduce inflammation by attenuating the production of proinflammatory cytokines (IL-1β and TNF-α) at 3 h after the injury. It has also been shown to reduce the severity of brain damage and improve cognitive function and recovery.
1709:
of sorts for allopregnanolone. As a result, there has been some interest in using oral progesterone to treat catamenial epilepsy, as well as other menstrual cycle-related and neurosteroid-associated conditions. In addition to oral progesterone, oral
9638:
1200:(GPBAR1, or TGR5). However, it is only able to do so at micromolar concentrations, which, similarly to the case of the L-VGCCs, are far greater than the low nanomolar concentrations of allopregnanolone estimated to be present in the brain.
628:
10545:
1682:
It has been suggested that allopregnanolone and its precursor pregnenolone may have therapeutic potential for treatment of various symptoms of alcohol use disorders by restoring deficits in GABAergic inhibition, moderating
3814:
Lamba V, Yasuda K, Lamba JK, Assem M, Davila J, Strom S, Schuetz EG (September 2004). "PXR (NR1I2): splice variants in human tissues, including brain, and identification of neurosteroids and nicotine as PXR activators".
10533:
4002:
Bäckström T, Haage D, Löfgren M, Johansson IM, Strömberg J, Nyberg S, et al. (September 2011). "Paradoxical effects of GABA-A modulators may explain sex steroid induced negative mood symptoms in some persons".
4496:
Andréen L, Spigset O, Andersson A, Nyberg S, Bäckström T (June 2006). "Pharmacokinetics of progesterone and its metabolites allopregnanolone and pregnanolone after oral administration of low-dose progesterone".
2661:
Rougé-Pont F, Mayo W, Marinelli M, Gingras M, Le Moal M, Piazza PV (July 2002). "The neurosteroid allopregnanolone increases dopamine release and dopaminergic response to morphine in the rat nucleus accumbens".
12304:
10392:
10785:
3718:"Characterization, neurosteroid binding and brain distribution of human membrane progesterone receptors δ and {epsilon} (mPRδ and mPR{epsilon}) and mPRδ involvement in neurosteroid inhibition of apoptosis"
3182:
Reddy DS, Rogawski MA, Rogawski MA, Olsen RW, Delgado-Escueta AV, Reddy DS, Rogawski MA (2012). "Neurosteroids — Endogenous
Regulators of Seizure Susceptibility and Role in the Treatment of Epilepsy".
4138:
Andréen L, Sundström-Poromaa I, Bixo M, Nyberg S, Bäckström T (August 2006). "Allopregnanolone concentration and mood--a bimodal association in postmenopausal women treated with oral progesterone".
4049:
Andréen L, Nyberg S, Turkmen S, van Wingen G, Fernández G, Bäckström T (September 2009). "Sex steroid induced negative mood may be explained by the paradoxical effect mediated by GABAA modulators".
9538:
5107:
8488:
10541:
10529:
10387:
11114:
1925:
Mahendroo M, Wilson JD, Richardson JA, Auchus RJ (July 2004). "Steroid 5alpha-reductase 1 promotes 5alpha-androstane-3alpha,17beta-diol synthesis in immature mouse testes by two pathways".
8570:
3434:
Bullock AE, Clark AL, Grady SR, Robinson SF, Slobe BS, Marks MJ, Collins AC (June 1997). "Neurosteroids modulate nicotinic receptor function in mouse striatal and thalamic synaptosomes".
1526:, is an endogenous inhibitory neurosteroid with similar properties to those of allopregnanolone, and the 3β-methyl analogue of allopregnanolone, ganaxolone, is under development to treat
2393:"A new generation of antidepressants: an update on the pharmaceutical pipeline for novel and rapid-acting therapeutics in mood disorders based on glutamate/GABA neurotransmitter systems"
1705:
progesterone, elevates allopregnanolone levels in the body with good dose-to-serum level correlations. Due to this, it has been suggested that oral progesterone could be described as a
1405:
and is also known as 5α-pregnan-3α-ol-20-one, 5α-pregnane-3α-ol-20-one, 3α-hydroxy-5α-pregnan-20-one, or 3α,5α-tetrahydroprogesterone (3α,5α-THP). It is closely related structurally to
3129:
the fetus is sedated by the low oxygen tension of the fetal blood and the neurosteroid anesthetics pregnanolone and the sleep-inducing prostaglandin D2 provided by the placenta (36).
5463:
2288:
147:
5102:
3250:
Pinna G, Uzunova V, Matsumoto K, Puia G, Mienville JM, Costa E, Guidotti A (January 2000). "Brain allopregnanolone regulates the potency of the GABA(A) receptor agonist muscimol".
13831:
12784:
2321:"ChemIDplus - 516-54-1 - AURFZBICLPNKBZ-SYBPFIFISA-N - Brexanolone [USAN] - Similar structures search, synonyms, formulas, resource links, and other chemical information"
14776:
5214:
3223:
Kokate TG, Svensson BE, Rogawski MA (September 1994). "Anticonvulsant activity of neurosteroids: correlation with gamma-aminobutyric acid-evoked chloride current potentiation".
12779:
2473:
2500:
10537:
5468:
3956:
Keitel V, Görg B, Bidmon HJ, Zemtsova I, Spomer L, Zilles K, Häussinger D (November 2010). "The bile acid receptor TGR5 (Gpbar-1) acts as a neurosteroid receptor in brain".
8600:
7289:
10707:
5087:
11757:
9985:
14883:
12226:
12193:
65:
ALLO; ALLOP; SAGE-547; SGE-102; 5α-Pregnan-3α-ol-20-one; 5α-Pregnane-3α-ol-20-one; 3α-Hydroxy-5α-pregnan-20-one; 3α,5α-Tetrahydroprogesterone; 3α,5α-THP, brexanolone (
1841:
Meyer HH, Jewgenow K, Hodges JK (February 1997). "Binding activity of 5alpha-reduced gestagens to the progestin receptor from
African elephant (Loxodonta africana)".
14052:
14042:
11107:
2816:
Terán-Pérez G, Arana-Lechuga Y, Esqueda-León E, Santana-Miranda R, Rojas-Zamorano JÁ, Velázquez
Moctezuma J (October 2012). "Steroid hormones and sleep regulation".
4602:
Piper T, Schlug C, Mareck U, Schänzer W (May 2011). "Investigations on changes in ¹³C/¹²C ratios of endogenous urinary steroids after pregnenolone administration".
2089:
8615:
8605:
5267:
4368:
1691:(e.g., anxiety, depression, seizures, sleep disturbance, pain) that are believed to contribute to the downward spiral of the addiction may also be controlled with
1542:
In March 2019, brexanolone was approved in the United States for the treatment of postpartum depression (PPD) in adult women, the first drug approved by the U.S.
13867:
6379:
4735:
He J, Evans CO, Hoffman SW, Oyesiku NM, Stein DG (October 2004). "Progesterone and allopregnanolone reduce inflammatory cytokines after traumatic brain injury".
3572:
Rupprecht R, Reul JM, Trapp T, van
Steensel B, Wetzel C, Damm K, et al. (September 1993). "Progesterone receptor-mediated effects of neuroactive steroids".
1627:
for use by intravenous infusion. Each mL of brexanolone solution contains 5 mg allopregnanolone, 250 mg sulfobutyl ether β-cyclodextrin, 0.265 mg
14057:
14878:
12629:
11317:
10617:
10501:
10427:
2851:
Patte-Mensah C, Meyer L, Taleb O, Mensah-Nyagan AG (February 2014). "Potential role of allopregnanolone for a safe and effective therapy of neuropathic pain".
1879:
Frye C, Seliga A (May 2002). "Olanzapine and progesterone have dose-dependent and additive effects to enhance lordosis and progestin concentrations of rats".
12489:
12188:
10491:
9922:
8590:
8575:
1033:, including anxiolytic, sedative, and anticonvulsant activity. Endogenously produced allopregnanolone exerts a neurophysiological role by fine-tuning of GABA
188:
13824:
11100:
10921:
10525:
10496:
8560:
8555:
8550:
14037:
1064:, though the implications of this action are unclear. In addition to its actions on GABA receptors, allopregnanolone, like progesterone, is known to be a
805:
Women experiencing moderate to severe postpartum depression when treated with a single dose of intravenous brexanolone display a significant reduction in
12459:
10382:
10377:
8595:
670:
InChI=1S/C21H34O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h14-19,23H,4-12H2,1-3H3/t14-,15+,16-,17+,18-,19-,20-,21+/m0/s1
1228:
levels) inhibit the activity of the receptor, while lower and higher concentration increases stimulate it. This seems to be a common effect of many GABA
13597:
11462:
10516:
14706:
11080:
10846:
9890:
9624:
8585:
5438:
13090:
1659:
are generally required for the full infusion. More than five infusion bags are necessary for patients weighing more than 90 kg (200 lbs).
11442:
10197:
9792:
7444:
7282:
6265:
3860:"Inhibition of evoked glutamate release by neurosteroid allopregnanolone via inhibition of L-type calcium channels in rat medial prefrontal cortex"
3350:
Morris KD, Moorefield CN, Amin J (October 1999). "Differential modulation of the gamma-aminobutyric acid type C receptor by neuroactive steroids".
13817:
12594:
10481:
6346:
12409:
13907:
12219:
11619:
10683:
10679:
10675:
10667:
4639:"Allopregnanolone elevations following pregnenolone administration are associated with enhanced activation of emotion regulation neurocircuits"
14077:
13882:
11397:
10976:
10971:
10961:
1236:(which reliably elevates allopregnanolone levels) has been found to have negative effects on mood, while higher doses have a neutral effect.
913:
effects. Fluctuations in the levels of allopregnanolone and the other neurosteroids seem to play an important role in the pathophysiology of
79:
14726:
12057:
11367:
10926:
7298:
7161:
6412:
642:
4095:
Bäckström T, Bixo M, Johansson M, Nyberg S, Ossewaarde L, Ragagnin G, et al. (February 2014). "Allopregnanolone and mood disorders".
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975:
development; placental progesterone in the male fetus is the feedstock of this pathway; deficiencies in this pathway lead to insufficient
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8663:
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11322:
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10795:
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10274:
9862:
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9543:
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8827:
8822:
8817:
8807:
8658:
5031:
1594:
785:. The long administration time, as well as the cost for a one-time treatment, have raised concerns about accessibility for many women.
3669:"Membrane progesterone receptors: evidence for neuroprotective, neurosteroid signaling and neuroendocrine functions in neuronal cells"
14486:
14092:
14007:
13538:
12212:
11599:
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11507:
11482:
11387:
11212:
11207:
11034:
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9915:
9018:
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States, (Trial 1/NCT02942004, Trial 3/NCT02614541, Trial 2/ NCT02942017) of 247 women with moderate or severe postpartum depression.
14148:
11624:
5393:
13448:
11897:
10891:
6207:
4902:
for "A Study to
Evaluate Safety and Efficacy of SAGE-547 in Participants With Moderate Postpartum Depression (547-PPD-202C)" at
2021:
1224:
receptor – moderate level increases (in the range of 1.5–2 nmol/L total allopregnanolone, which are approximately equivalent to
1174:
4930:
2956:"The role of sex steroids in catamenial epilepsy and premenstrual dysphoric disorder: implications for diagnosis and treatment"
833:(3–13% at infusion doses of 90–270 μg over a one-hour period). Serious or severe adverse effects are rare but may include
5714:
4878:
for "A Study to
Evaluate Efficacy and Safety of SAGE-547 in Participants With Severe Postpartum Depression (547-PPD-202B)" at
14908:
13793:
13788:
7218:
4543:
4559:
Saudan C, Desmarchelier A, Sottas PE, Mangin P, Saugy M (March 2005). "Urinary marker of oral pregnenolone administration".
1445:
The biosynthesis of allopregnanolone in the brain starts with the conversion of progesterone into 5α-dihydroprogesterone by
12399:
9908:
4688:"Brain distribution and behavioral effects of progesterone and pregnenolone after intranasal or intravenous administration"
1197:
1170:
4783:
Herd MB, Belelli D, Lambert JJ (October 2007). "Neurosteroid modulation of synaptic and extrasynaptic GABA(A) receptors".
6445:
2081:
1672:
1056:
exhibit the greatest potentiation. Allopregnanolone has also been found to act as a positive allosteric modulator of the
4356:
14888:
12875:
6313:
3046:
Mellor DJ, Diesch TJ, Gunn AJ, Bennet L (November 2005). "The importance of 'awareness' for understanding fetal pain".
130:
4268:"Alprazolam and standard antidepressants in the treatment of depression: a meta-analysis of the antidepressant effect"
3906:"Inhibition of recombinant L-type voltage-gated calcium channels by positive allosteric modulators of GABAA receptors"
1616:
1450:
12584:
11134:
11062:
9886:
9317:
5257:
4390:
3767:"Progesterone receptor A (PRA) and PRB-independent effects of progesterone on gonadotropin-releasing hormone release"
3199:
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1575:
996:
765:
662:
143:
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7235:
5669:
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1069:
806:
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receptor. While allopregnanolone, like other inhibitory neurosteroids such as THDOC, positively modulates all GABA
1025:. Allopregnanolone has effects similar to those of other positive allosteric modulators of the GABA action at GABA
2443:
1684:
358:
218:
111:
12880:
12284:
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1150:
receptor. The action of allopregnanolone at these receptors may be related, in part, to its neuroprotective and
14903:
14308:
13798:
13671:
12624:
11557:
11153:
6020:
5654:
5363:
5024:
1531:
1131:
1080:. Along with the other inhibitory neurosteroids, allopregnanolone appears to have little or no action at other
834:
1623:. It is provided at an allopregnanolone concentration of 100 mg/20 mL (5 mg/mL) in single-dose
13681:
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8837:
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properties. Also like progesterone, recent evidence has shown that allopregnanolone is an activator of the
778:
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12354:
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2050:"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)"
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Increased levels of allopregnanolone can produce paradoxical effects, including negative mood, anxiety,
14838:
12870:
11571:
11297:
11167:
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5493:
5453:
5262:
5237:
5134:
4983:
4239:
Warner MD, Peabody CA, Whiteford HA, Hollister LE (April 1988). "Alprazolam as an antidepressant".
3477:
Wetzel CH, Hermann B, Behl C, Pestel E, Rammes G, Zieglgänsberger W, et al. (September 1998).
2527:
1747:"5α-Pregnane-3α-ol-20-one Identified as an Active Molecular Species of Steroid Anesthetic in Brain"
1667:
Brexanolone was under development as an intravenously administered medication for the treatment of
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4446:"A Rationale for Allopregnanolone Treatment of Alcohol Use Disorders: Basic and Clinical Studies"
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receptor and modulating the action of several positive allosteric modulators and agonists at GABA
303:
158:
52:
2710:"Neurosteroids' effects and mechanisms for social, cognitive, emotional, and physical functions"
1515:(2β-(2,2-dimethyl-4-morpholinyl)-3α-hydroxy-11,20-dioxo-5α-pregnan-21-yl methanesulfonate), and
793:
Brexanolone is used to treat postpartum depression in adult women, administered as a continuous
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Ducharme N, Banks WA, Morley JE, Robinson SM, Niehoff ML, Mattern C, Farr SA (September 2010).
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Bäckström T, Andersson A, Andreé L, Birzniece V, Bixo M, Björn I, et al. (December 2003).
1722:
1454:
1317:
1313:
1285:
956:
862:
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1220:. This appears to be because allopregnanolone possesses biphasic, U-shaped actions at the GABA
771:
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receptor positive allosteric modulators. In accordance, acute administration of low doses of
1107:
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821:(13–21%), headache (18%), nausea (10%), dry mouth (3–11%), loss of consciousness (3–5%), and
741:
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14133:
5604:
5599:
5433:
5428:
5209:
4299:"Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis"
4297:
Agís-Balboa RC, Pinna G, Zhubi A, Maloku E, Veldic M, Costa E, Guidotti A (September 2006).
3003:
Finocchi C, Ferrari M (May 2011). "Female reproductive steroids and neuronal excitability".
2759:"Changes in brain testosterone and allopregnanolone biosynthesis elicit aggressive behavior"
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Nik AM, Pressly B, Singh V, Antrobus S, Hulsizer S, Rogawski MA, et al. (July 2017).
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signaling, and inhibiting excessive neuroimmune activation. Many co-occurring symptoms of
8:
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2344:"Pharmacotherapy of Postpartum Depression: Current Approaches and Novel Drug Development"
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Allopregnanolone possesses a wide variety of effects, including, in no particular order,
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Modulator, in the
Treatment of Postpartum Depression in Adults: A Comprehensive Review"
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receptor-potentiating neurosteroids may preferentially target δ-subunit–containing GABA
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3479:"Functional antagonism of gonadal steroids at the 5-hydroxytryptamine type 3 receptor"
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2612:"Review of Allopregnanolone Agonist Therapy for the Treatment of Depressive Disorders"
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1782:
1165:
receptor positive allosteric modulators, allopregnanolone has been found to act as an
14461:
14168:
13160:
12769:
12714:
12664:
12379:
12162:
11882:
11762:
11642:
10476:
10356:
10158:
9857:
9628:
9571:
9512:
9280:
8852:
7947:
7724:
7719:
7267:
7195:
7097:
6616:
5719:
5639:
5224:
5164:
4853:
4824:"Neurosteroids as novel antidepressants and anxiolytics: GABA-A receptors and beyond"
4810:
4806:
4752:
4717:
4668:
4619:
4576:
4539:
4514:
4475:
4416:
4338:
4279:
4248:
4221:
4192:"Neurosteroids as novel antidepressants and anxiolytics: GABA-A receptors and beyond"
4155:
4124:
4112:
4066:
4020:
3973:
3935:
3881:
3840:
3796:
3747:
3698:
3646:
3589:
3585:
3554:
3540:
3500:
3451:
3408:
3359:
3332:
3267:
3232:
3205:
3195:
3168:
3112:
3063:
3020:
2985:
2928:
2880:
2868:
2833:
2798:
2739:
2679:
2675:
2643:
2589:
2528:"Zulresso (brexanolone) dosing, indications, interactions, adverse effects, and more"
2422:
2373:
2237:
2217:
2175:
2163:
1942:
1896:
1858:
1820:
1763:
1746:
1484:
1281:
1146:, with its activity at these receptors about a magnitude more potent than at the GABA
914:
890:
886:
761:
103:
11661:
11657:
11585:
6043:
6038:
5980:
5549:
4890:
for "A Study to
Evaluate SAGE-547 in Patients With Severe Postpartum Depression" at
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4588:
4510:
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4032:
3985:
3601:
3463:
3420:
3279:
3124:
2940:
2864:
1954:
1908:
1280:
receptors. It is possible that neurosteroids like allopregnanolone may act on other
14928:
14746:
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14348:
14278:
14153:
14067:
13917:
13717:
13244:
13205:
12599:
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3012:
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2815:
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2725:
2721:
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2671:
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2579:
2569:
2412:
2404:
2363:
2355:
2227:
2209:
2155:
1934:
1888:
1850:
1810:
1802:
1758:
1676:
1609:
1461:
1409:(pregn-5-en-3β-ol-20-dione), progesterone (pregn-4-ene-3,20-dione), the isomers of
1353:
1151:
1104:
1097:
1093:
768:
577:
311:
246:
201:
89:
5539:
4898:
4886:
4874:
4430:
2552:
Edinoff AN, Odisho AS, Lewis K, Kaskas A, Hunt G, Cornett EM, et al. (2021).
2320:
1806:
1044:
Allopregnanolone acts as a highly potent positive allosteric modulator of the GABA
409:
14852:
14423:
14318:
14198:
13219:
13180:
13140:
12564:
12429:
11687:
10627:
10471:
10442:
10312:
10174:
10164:
10126:
9825:
9690:
9674:
9662:
9616:
9567:
9382:
9357:
9352:
9166:
8899:
8752:
7554:
7549:
7411:
7344:
7107:
7101:
6914:
6288:
6105:
6053:
6025:
5935:
5930:
5744:
5734:
5478:
5448:
5378:
5373:
5343:
4703:
3765:
Sleiter N, Pang Y, Park C, Horton TH, Dong J, Thomas P, Levine JE (August 2009).
3107:
3090:
2408:
1652:
1554:
1457:
into allopregnanolone. Allopregnanolone in the brain is produced by cortical and
1434:
1430:
1357:
1341:
1305:
1248:
receptor PAMs like brexanolone have antidepressant effects is unknown. Other GABA
1166:
906:
689:
299:
277:
254:
22:
11589:
11581:
6176:
4839:
4207:
2971:
1446:
1421:(5-pregnane-3,20-diol). In addition, allopregnanolone is one of four isomers of
777:
Brexanolone was approved for medical use in the United States in 2019. The U.S.
14771:
14691:
14561:
14418:
14273:
14238:
13897:
13318:
13278:
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13190:
13170:
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13007:
13002:
12967:
12684:
12374:
11867:
11517:
11312:
11257:
11014:
10916:
10586:
10506:
10340:
10115:
10073:
9837:
9666:
9575:
9442:
9437:
8861:
7749:
7654:
7529:
7494:
7489:
7375:
7340:
7229:
6671:
6380:
6278:
6172:
6068:
6048:
5910:
5614:
5338:
5277:
5169:
5126:
5117:
4303:
Proceedings of the
National Academy of Sciences of the United States of America
4267:
3836:
3632:
2829:
2763:
Proceedings of the
National Academy of Sciences of the United States of America
2359:
2159:
1414:
1406:
1253:
1126:
is reduced to produce allopregnanolone, and progesterone is reduced to produce
1073:
1030:
1018:
902:
854:
753:
181:
11593:
9900:
4151:
3016:
2574:
2501:"New Postpartum Depression Drug Could Be Hard To Access For Moms Most In Need"
1938:
1256:, are not thought of as antidepressants and have no proven efficacy, although
1130:). In addition, allopregnanolone was reported in 2012 to be an agonist of the
14862:
14711:
14586:
14471:
14433:
14328:
14293:
14228:
14027:
13987:
13887:
13647:
13543:
13443:
13348:
13175:
12925:
12885:
12719:
12604:
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12147:
11977:
11947:
11887:
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11217:
10745:
10655:
10602:
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9596:
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9387:
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8335:
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7867:
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1644:
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1085:
233:
4323:
4298:
3921:
3394:
3159:
3142:
2923:
2898:
2783:
2758:
1714:
has also been found to act as a prodrug of allopregnanolone, though also of
39:
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11992:
11987:
11902:
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11634:
11432:
11352:
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10779:
10723:
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10671:
10639:
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10226:
9705:
9447:
9397:
9367:
9312:
9270:
9265:
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9250:
9245:
9174:
8832:
8797:
8792:
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8711:
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8320:
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8087:
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8002:
7827:
7817:
7709:
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7514:
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6731:
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6524:
6509:
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6225:
6189:
6063:
6058:
6010:
5955:
5945:
5940:
5826:
5776:
5398:
5348:
5199:
5194:
5082:
4998:
4988:
4953:
4939:
4857:
4814:
4756:
4721:
4672:
4623:
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4518:
4479:
4342:
4225:
4159:
4116:
4070:
4024:
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3412:
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3271:
3209:
3116:
3067:
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2932:
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2837:
2802:
2743:
2683:
2647:
2593:
2426:
2377:
2241:
2167:
1946:
1900:
1854:
1711:
1692:
1656:
1500:
1426:
1418:
1369:
1225:
1213:
1010:
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1002:
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745:
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196:
177:
9975:
4283:
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3593:
3504:
3455:
3236:
1862:
1561:
designations, and granted approval of Zulresso to Sage Therapeutics, Inc.
14781:
14751:
14731:
14681:
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14551:
14536:
14506:
14333:
14288:
14248:
14243:
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14012:
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13877:
13577:
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12017:
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11872:
11802:
11792:
11782:
11777:
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11457:
11422:
11412:
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11402:
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11332:
11307:
11302:
11222:
11024:
10941:
10807:
10749:
10741:
10631:
10486:
10407:
10397:
10344:
10294:
10193:
10178:
10150:
10021:
9787:
9782:
9752:
9732:
9487:
9467:
9417:
9240:
9222:
9217:
9207:
9184:
9179:
9146:
9068:
8909:
8876:
8866:
8722:
8706:
8610:
8493:
8410:
8390:
8380:
8350:
8315:
8267:
8257:
8217:
8212:
8187:
8172:
8132:
8122:
8057:
8027:
7977:
7922:
7897:
7877:
7872:
7837:
7734:
7689:
7644:
7624:
7589:
7564:
7459:
7436:
7360:
7330:
7082:
6979:
6844:
6779:
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6764:
6721:
6706:
6691:
6681:
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6641:
6514:
6484:
6479:
6425:
6402:
6397:
6369:
6326:
6303:
6293:
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6141:
6095:
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5870:
5768:
5659:
5296:
5272:
5059:
4978:
4637:
Sripada RK, Marx CE, King AP, Rampton JC, Ho SS, Liberzon I (June 2013).
3782:
3733:
2628:
2208:. Progress in Brain Research. Vol. 186. Elsevier. pp. 113–137.
1824:
1458:
1119:
1118:
of the PR, and for this reason, allopregnanolone can produce PR-mediated
878:
721:
715:
97:
9852:
2206:
Sex Differences in the Human Brain, their Underpinnings and Implications
1276:
receptors, and enhance both tonic and phasic inhibition mediated by GABA
429:
14761:
14721:
14666:
14656:
14596:
14581:
14566:
14546:
14521:
14516:
14496:
14491:
14448:
14438:
14403:
14378:
14358:
14323:
14302:
14258:
14233:
14017:
13982:
13967:
13962:
13931:
13892:
13872:
13607:
13572:
13533:
13523:
13503:
13433:
13388:
13368:
13263:
13239:
13200:
13195:
13130:
13120:
13081:
13056:
13041:
12992:
12962:
12937:
12834:
12699:
12589:
12554:
12509:
12449:
12127:
12107:
12067:
12042:
12007:
11997:
11942:
11932:
11927:
11917:
11892:
11857:
11812:
11807:
11787:
11772:
11732:
11697:
11629:
11614:
11604:
11357:
11347:
11292:
11252:
11237:
10981:
10956:
10936:
10931:
10906:
10811:
10799:
10771:
10689:
10663:
10659:
10645:
10635:
10606:
10594:
10590:
10561:
10556:
10511:
10450:
10432:
10417:
10336:
10320:
10316:
10298:
10282:
10234:
10222:
10208:
10145:
10068:
10026:
9820:
9772:
9767:
9685:
9680:
9586:
9557:
9553:
9462:
9427:
9372:
9362:
9322:
9255:
9083:
9048:
9013:
9008:
8962:
8952:
8881:
8842:
8802:
8787:
8767:
8757:
8696:
8691:
8681:
8648:
8630:
8526:
8473:
8438:
8385:
8375:
8345:
8340:
8277:
8252:
8207:
8182:
8162:
8142:
8137:
8127:
8107:
8062:
8052:
8037:
7997:
7992:
7962:
7917:
7912:
7892:
7882:
7862:
7857:
7847:
7807:
7802:
7797:
7792:
7787:
7777:
7772:
7767:
7739:
7594:
7509:
7504:
7390:
7380:
7355:
7200:
7186:
7172:
7078:
7074:
7070:
7024:
6994:
6989:
6984:
6964:
6934:
6924:
6884:
6869:
6849:
6736:
6716:
6686:
6666:
6646:
6606:
6554:
6539:
6534:
6494:
6458:
6430:
6359:
6336:
6331:
6283:
6255:
6250:
6245:
6230:
6220:
6100:
5544:
5040:
4461:
3969:
1688:
1640:
1516:
1504:
1496:
1492:
1488:
1487:
of allopregnanolone with similar activity and effects exist, including
1361:
1321:
1257:
1217:
993:
945:
910:
898:
858:
830:
729:
604:
440:
172:
7252:
5009:
4272:
Journal of the Medical Association of Thailand = Chotmaihet Thangphaet
3684:
14686:
14676:
14671:
14661:
14646:
14631:
14576:
14531:
14501:
14363:
14343:
14268:
14208:
14203:
14072:
14002:
13992:
13937:
13383:
13373:
13303:
13283:
13258:
13225:
Normethandrone (methylestrenolone, normethandrolone, normethisterone)
13135:
13110:
12957:
12947:
12915:
12900:
12854:
12809:
12764:
12709:
12659:
12434:
12384:
12324:
11967:
11962:
11937:
11912:
11907:
11877:
11827:
11817:
11797:
11667:
11452:
11447:
11437:
11262:
11242:
11232:
11227:
11182:
11009:
10966:
10951:
10946:
10817:
10761:
10757:
10650:
10581:
10521:
10461:
10456:
10422:
10332:
10328:
10269:
10259:
10238:
10184:
10088:
10055:
9810:
9762:
9757:
9742:
9700:
9695:
9653:
9648:
9643:
9601:
9497:
9482:
9422:
9407:
9392:
9212:
9123:
9078:
9043:
9033:
9003:
8998:
8983:
8957:
8919:
8914:
8891:
8886:
8871:
8777:
8772:
8653:
8531:
8521:
8513:
8448:
8425:
8405:
8400:
8370:
8355:
8325:
8307:
8297:
8292:
8287:
8282:
8262:
8247:
8242:
8232:
8227:
8222:
8192:
8167:
8117:
8102:
8097:
8082:
8067:
8047:
8042:
8032:
8022:
8017:
8012:
7932:
7927:
7902:
7832:
7812:
7782:
7704:
7639:
7569:
7559:
7524:
7421:
7325:
7088:
6974:
6909:
6904:
6879:
6874:
6864:
6859:
6769:
6711:
6676:
6656:
6621:
6577:
6435:
6392:
6364:
6298:
6240:
6085:
6033:
5524:
5179:
2605:
2603:
1698:
1512:
1508:
1376:
1349:
1110:(PR). However, allopregnanolone can be intracellularly oxidized into
933:
894:
737:
733:
395:
332:
307:
83:
6413:
6266:
4615:
3858:
Hu AQ, Wang ZM, Lan DM, Fu YM, Zhu YH, Dong Y, Zheng P (July 2007).
1417:(3-dihydroprogesterone; pregn-4-en-3-ol-20-one), and the isomers of
1072:, and also appears to act as a negative allosteric modulator of the
14591:
14571:
14541:
14413:
14373:
14223:
14213:
14087:
13518:
13473:
13076:
13071:
12829:
12469:
12369:
12364:
12121:
12047:
11862:
11852:
11672:
11427:
11417:
11377:
11372:
11362:
11327:
11277:
11272:
11177:
11004:
10790:
10775:
10765:
10753:
10622:
10612:
10598:
10412:
10278:
10254:
10213:
10078:
9867:
9800:
9777:
9726:
9722:
9718:
9658:
9632:
9492:
9452:
9432:
9412:
9402:
9342:
9337:
9151:
9113:
9063:
9028:
8993:
8988:
8972:
8967:
8947:
8942:
8937:
8924:
8812:
8620:
8497:
8483:
8458:
8453:
8443:
8415:
8202:
8197:
8177:
8157:
8152:
7952:
7907:
7887:
7852:
7842:
7729:
7684:
7674:
7579:
7474:
7454:
7370:
6839:
6795:
6519:
6504:
6347:
5519:
5508:
5305:
5282:
5174:
4797:
3091:"The emergence of human consciousness: from fetal to neonatal life"
2850:
2026:
1527:
1268:
receptors and subpopulations differently than benzodiazepines. GABA
1103:
Unlike progesterone, allopregnanolone is inactive at the classical
999:
941:
882:
866:
842:
826:
818:
725:
489:
420:
125:
30:
13402:
5238:
11-Dehydrocorticosterone (11-oxocorticosterone, 17-deoxycortisone)
4137:
2600:
1783:"Progesterone biotransformation by plant cell suspension cultures"
1260:
has historically been prescribed for depression. Neurosteroid GABA
627:
14801:
14786:
14716:
14178:
13902:
13338:
13313:
13308:
13229:
12905:
12117:
12097:
11677:
11648:
11502:
11497:
11492:
11487:
11477:
11381:
11267:
11202:
11197:
10901:
10733:
10402:
10348:
10286:
10189:
10093:
10039:
10031:
10016:
9995:
9990:
9814:
9804:
9563:
9502:
9477:
9472:
9347:
9327:
9307:
9128:
9118:
9103:
9088:
9073:
9058:
9053:
9038:
9023:
8904:
8643:
8503:
7957:
7664:
7365:
6661:
5534:
5529:
5043:
3379:"Neuroactive steroids and human recombinant rho1 GABAC receptors"
2896:
2341:
2306:
This article incorporates text from this source, which is in the
1740:
1738:
1706:
1612:
1425:(3,5-tetrahydroprogesterone), with the other three isomers being
1402:
1115:
918:
874:
696:
12329:
11707:
11527:
11337:
11122:
10729:
10047:
10003:
9747:
9710:
9332:
9285:
9156:
9138:
9098:
8782:
8580:
6385:
Tooltip Noradrenergic and specific serotonergic antidepressants
6208:
4908:
4558:
4238:
3525:"Neurosteroid regulation of central nervous system development"
2342:
Frieder A, Fersh M, Hainline R, Deligiannidis KM (March 2019).
1924:
1413:(5-dihydroprogesterone; 5-pregnane-3,20-dione), the isomers of
1325:
1189:
1181:
520:
287:
283:
12625:
Hydroxyprogesterone heptanoate (hydroxyprogesterone enanthate)
4048:
4001:
3571:
2660:
1735:
1507:(11α-(dimethylamino)-2β-ethoxy-3α-hydroxy-5α-pregnan-20-one),
12077:
10362:
9108:
6576:
4822:
Zorumski CF, Paul SM, Covey DF, Mennerick S (November 2019).
4495:
4190:
Zorumski CF, Paul SM, Covey DF, Mennerick S (November 2019).
1384:
1380:
1329:
1143:
1139:
1135:
1053:
972:
949:
618:
500:
342:
337:
291:
12620:
Hydroxyprogesterone caproate (hydroxyprogesterone hexanoate)
4094:
2609:
1511:(21-chloro-3α-hydroxy-2β-morpholin-4-yl-5β-pregnan-20-one),
545:
10822:
10694:
10367:
8541:
6446:
4685:
4296:
4265:
2610:
Walkery A, Leader LD, Cooke E, VandenBerg A (9 July 2021).
2146:
Scott LJ (May 2019). "Brexanolone: First Global Approval".
1624:
480:
13839:
6314:
4821:
4189:
3181:
2953:
1679:, but development for these indications was discontinued.
11135:
10308:
4601:
4278:(3). Centre for Reviews and Dissemination (UK): 183–188.
3910:
The Journal of Pharmacology and Experimental Therapeutics
3433:
3383:
The Journal of Pharmacology and Experimental Therapeutics
3249:
3225:
The Journal of Pharmacology and Experimental Therapeutics
2505:
2277:"FDA approves first treatment for post-partum depression"
2057:
1203:
13852:
3955:
3184:
Jasper's Basic Mechanisms of the Epilepsies, 4th Edition
2551:
2082:"DEA Schedules Postpartum Depression Treatment Zulresso"
817:
Side effects of brexanolone include dizziness (10–20%),
3617:"Clinical Potential of Neurosteroids for CNS Disorders"
3476:
3292:
2954:
Guille C, Spencer S, Cavus I, Epperson CN (July 2008).
13672:
12630:
Hydroxyprogesterone heptanoate benzilic acid hydrazone
11558:
11154:
7297:
4636:
4531:
3222:
3045:
2899:"Pathogenesis in menstrual cycle-linked CNS disorders"
1744:
702:. As a medication, allopregnanolone is referred to as
14836:
13682:
10833:
4734:
4525:
3813:
3764:
3299:
Receptor Subtype Modulators and Blockers Using DiSBAC
1745:
Krieger NR, Mok WM, Herschkowitz S (September 1990).
1387:. Less than 1% is excreted as unchanged brexanolone.
12234:
6418:
Tooltip Serotonin antagonist and reuptake inhibitors
6271:
Tooltip Serotonin–norepinephrine reuptake inhibitors
4535:
Complementary and Alternative Therapies for Epilepsy
3377:
Li W, Jin X, Covey DF, Steinbach JH (October 2007).
3349:
6752:
6352:
Tooltip Norepinephrine–dopamine reuptake inhibitors
4984:
Progestogen (as a medication; including progestins)
4532:Devinsky O, Schachter S, Pacia S (1 January 2005).
4185:
4183:
4181:
4179:
4177:
3376:
3088:
2042:
1840:
1780:
13407:Tooltip Selective progesterone receptor modulators
4782:
2756:
14884:GABAA-rho receptor positive allosteric modulators
9850:Unsorted benzodiazepine site positive modulators:
6594:
2390:
2016:
2014:
2012:
2010:
2008:
2006:
2004:
2002:
2000:
1998:
1996:
1994:
1992:
1990:
1988:
1986:
1984:
1522:The 21-hydroxylated derivative of this compound,
1316:of brexanolone is approximately 3 L/kg. Its
1288:, and others, to mediate antidepressant effects.
929:, and various other neuropsychiatric conditions.
14860:
6817:
5253:11β-Hydroxyprogesterone (21-deoxycorticosterone)
4443:
4266:Srisurapanont M, Boonyanaruthee V (March 1997).
4174:
1982:
1980:
1978:
1976:
1974:
1972:
1970:
1968:
1966:
1964:
1553:The FDA granted the application for brexanolone
408:
13718:11-Deoxycortisol (17α,21-dihydroxyprogesterone)
9930:
7154:
6213:Tooltip Selective serotonin reuptake inhibitors
4491:
4489:
4090:
4088:
4044:
4042:
3997:
3995:
3951:
3949:
3899:
3897:
3895:
3662:
3660:
3518:
3516:
3514:
3002:
2892:
2890:
2703:
2701:
2438:
2436:
1781:Yagen B, Gallili GE, Mateles RI (August 1978).
1647:to a target concentration of 1 mg/mL with
1017:of the action of γ-aminobutyric acid (GABA) at
383:
13091:11β-Methyl-19-nortestosterone dodecylcarbonate
12053:Trimetaphan camsilate (trimethaphan camsylate)
5555:16β,17α-Epiestriol (16β-hydroxy-17α-estradiol)
4450:Alcoholism: Clinical and Experimental Research
3715:
2757:Pinna G, Costa E, Guidotti A (February 2005).
1920:
1918:
1874:
1872:
557:DTXSID901016239 DTXSID1046342, DTXSID901016239
142:
14879:GABAA receptor positive allosteric modulators
13825:
12420:17α-Hydroxyprogesterone (hydroxyprogesterone)
12247:
12220:
12194:Acetylcholine metabolism/transport modulators
11108:
10992:
10879:
9916:
7283:
6157:
5025:
4924:
4444:Morrow AL, Boero G, Porcu P (February 2020).
3140:
2199:
2197:
2195:
2193:
2191:
2189:
2187:
2185:
1961:
1836:
1834:
1356:. It is not metabolized significantly by the
1284:, including membrane progesterone receptors,
1264:receptor PAMs are known to interact with GABA
1052:receptor isoforms, those isoforms containing
12410:16-Methylene-17α-hydroxyprogesterone acetate
12189:Muscarinic acetylcholine receptor modulators
4679:
4630:
4595:
4552:
4486:
4131:
4085:
4039:
3992:
3946:
3892:
3851:
3807:
3758:
3709:
3657:
3608:
3511:
3370:
3343:
3082:
3039:
2996:
2947:
2887:
2844:
2809:
2750:
2698:
2654:
2545:
2433:
2384:
2335:
2141:
2139:
2137:
2135:
2133:
2131:
2129:
2127:
1776:
1774:
1585:Zulresso is a brand name of the medication.
1134:(mPRs) discovered shortly before, including
129:
14108:
7299:
7188:
7005:
6945:
6451:Tooltip Serotonin modulator and stimulators
4538:. Demos Medical Publishing. pp. 378–.
4423:
3857:
3565:
3470:
3427:
2271:
2125:
2123:
2121:
2119:
2117:
2115:
2113:
2111:
2109:
2107:
2022:"Zulresso- brexanolone injection, solution"
1915:
1869:
1582:in the context of its use as a medication.
1491:(3α,21-dihydroxy-5α-pregnane-11,20-dione),
14159:Allopregnanedione (5α-dihydroprogesterone)
13832:
13818:
13713:11-Deoxycortisone (21-hydroxyprogesterone)
12805:Gestonorone caproate (gestronol hexanoate)
12227:
12213:
11115:
11101:
9923:
9909:
7290:
7276:
6319:Tooltip Norepinephrine reuptake inhibitors
6171:
6164:
6150:
5550:17α-Epiestriol (16α-hydroxy-17α-estradiol)
5032:
5018:
4931:
4917:
3666:
3614:
2903:Annals of the New York Academy of Sciences
2498:
2391:Wilkinson ST, Sanacora G (February 2019).
2269:
2267:
2265:
2263:
2261:
2259:
2257:
2255:
2253:
2251:
2182:
1878:
1831:
1499:(3α-hydroxy-3β-methyl-5α-pregnan-20-one),
559:
448:
12397:17α-Substituted progesterone derivatives:
12305:17α-Methyl-11-deoxycorticosterone acetate
11140:Tooltip Nicotinic acetylcholine receptors
4847:
4796:
4711:
4662:
4469:
4332:
4322:
4215:
3929:
3903:
3875:
3790:
3741:
3716:Pang Y, Dong J, Thomas P (January 2013).
3692:
3640:
3548:
3494:
3402:
3326:
3158:
3106:
3089:Lagercrantz H, Changeux JP (March 2009).
2979:
2922:
2792:
2782:
2733:
2637:
2627:
2583:
2573:
2416:
2367:
2231:
1814:
1771:
1762:
1239:
987:
468:
13857:Tooltip Constitutive androstane receptor
11683:Candocuronium iodide (chandonium iodide)
11081:Ionotropic glutamate receptor modulators
9960:
7046:
2104:
1368:of brexanolone is nine hours. Its total
1244:The mechanism by which neurosteroid GABA
809:which persisted 30 days post-treatment.
12840:Oxogestone phenpropionate (xinogestone)
12800:Gestonorone acetate (gestronol acetate)
7257:
5039:
2492:
2248:
1593:In the United States, brexanolone is a
555:
428:
102:
14861:
14612:Pregnanedione (5β-dihydroprogesterone)
13998:Pregnanedione (5β-dihydroprogesterone)
13677:Tooltip Membrane progesterone receptor
12430:Acetomepregenol (mepregenol diacetate)
11563:Tooltip negative allosteric modulators
11159:Tooltip positive allosteric modulators
5334:Adrenosterone (11-ketoandrostenedione)
4371:from the original on 28 September 2019
3522:
3048:Brain Research. Brain Research Reviews
1787:Applied and Environmental Microbiology
1564:
1495:(3α-hydroxy-5α-pregnane-11,20-dione),
982:
848:
13813:
13687:Tooltip Progestin and adipoQ receptor
12208:
11096:
10838:Tooltip N-Methyl-D-aspartate receptor
9904:
7271:
7256:
7141:
7045:
6816:
6575:
6188:
6145:
5545:16β-Epiestriol (16β-hydroxyestradiol)
5013:
4912:
2203:
2145:
2092:from the original on 3 September 2019
2076:
2074:
1843:General and Comparative Endocrinology
1619:(betadex sulfobutyl ether sodium), a
1519:(3α-hydroxy-5β-pregnan-11,20-dione).
1503:(21-hydroxy-5β-pregnane-3,20-dione),
1401:Allopregnanolone is a pregnane (C21)
1286:T-type voltage-gated calcium channels
1171:L-type voltage-gated calcium channels
528:
508:
227:
137:
120:
88:
70:
10530:4-hydroxyquinoline-3-carboxylic acid
10388:4-Phenyl-4-formyl-N-methylpiperidine
9891:GABA metabolism/transport modulators
4409:
2707:
2664:The European Journal of Neuroscience
2616:Drug Design, Development and Therapy
2291:from the original on 11 October 2019
1927:Molecular and Cellular Endocrinology
1685:corticotropin releasing factor (CRF)
1198:G protein-coupled bile acid receptor
800:
200:
10353:trichloroethane (methyl chloroform)
9508:Trichloroethane (methyl chloroform)
6757:Tooltip Tetracyclic antidepressants
5715:Estradiol 3-glucuronide 17β-sulfate
3817:Toxicology and Applied Pharmacology
3448:10.1046/j.1471-4159.1997.68062412.x
2818:Mini Reviews in Medicinal Chemistry
1673:super-refractory status epilepticus
1296:
695:which is made in the body from the
488:
399:
13:
12876:6,6-Difluoronorethisterone acetate
10957:Pesampator (BIIB-104, PF-04958242)
8571:11-Methoxy-12-hydroxydehydrokavain
4775:
4241:The Journal of Clinical Psychiatry
4017:10.1016/j.neuroscience.2011.03.061
3621:Trends in Pharmacological Sciences
3295:"Rapid Throughput Analysis of GABA
3192:10.1093/med/9780199746545.003.0077
3134:
2214:10.1016/B978-0-444-53630-3.00008-7
2204:Reddy DS (2010). "Neurosteroids".
2071:
1615:of synthetic allopregnanolone and
1603:
1464:and pyramidal-like neurons of the
971:, which occurs during normal male
16:Endogenous inhibitory neurosteroid
14:
14940:
13784:Progestogens and antiprogestogens
13191:Methoxydienone (methoxygonadiene)
12585:Fluoromedroxyprogesterone acetate
11768:Dimethyltubocurarine (metocurine)
9318:Acetylglycinamide chloral hydrate
7142:
6599:Tooltip Tricyclic antidepressants
5258:18-Hydroxy-11-deoxycorticosterone
5108:11β,17α,21-Trihydroxypregnenolone
4866:
4431:"Brexanolone - Sage Therapeutics"
4357:"Drug Trials Snapshots: Zulresso"
3060:10.1016/j.brainresrev.2005.01.006
2478:U.S. Food and Drug Administration
2474:"New Drug Therapy Approvals 2019"
2444:"Drug Approval Package: Zulresso"
1576:International Nonproprietary Name
1364:of brexanolone are inactive. The
1320:is more than 99%. Brexanolone is
14846:
13151:Dimethandrolone dodecylcarbonate
13084:; Anabolic–androgenic steroids:
12340:Progesterone 3-acetyl enol ether
11124:Nicotinic acetylcholine receptor
4969:Pharmacokinetics of progesterone
4964:Pharmacodynamics of progesterone
4938:
4807:10.1016/j.pharmthera.2007.03.007
4692:European Journal of Pharmacology
3904:Earl DE, Tietz EI (April 2011).
3615:Reddy DS, Estes WA (July 2016).
3541:10.1016/j.pharmthera.2007.04.011
2676:10.1046/j.1460-9568.2002.02084.x
2301:
2287:(Press release). 19 March 2019.
1764:10.1097/00000542-199009001-00702
1530:and other conditions, including
650:CC(=O)1CC21(CC32CC43(CC(C4)O)C)C
588:
38:
29:
12855:Segesterone acetate (nestorone)
12747:19-Norprogesterone derivatives:
12400:6α-Methyl-17α-bromoprogesterone
12148:Meclofenoxate (centrophenoxine)
11473:Suxethonium (succinyldicholine)
11468:Suxamethonium (succinylcholine)
9738:Menthyl isovalerate (validolum)
5464:Dihydrotestosterone glucuronide
4785:Pharmacology & Therapeutics
4749:10.1016/j.expneurol.2004.06.008
4728:
4511:10.1016/j.maturitas.2005.11.005
4437:
4383:
4349:
4290:
4259:
4232:
4109:10.1016/j.pneurobio.2013.07.005
3529:Pharmacology & Therapeutics
3303:(3) Membrane Potential Red Dye"
3286:
3243:
3216:
3175:
3143:"Alternative androgen pathways"
2865:10.1016/j.pneurobio.2013.07.004
2520:
2466:
2313:
1617:sulfobutyl ether β-cyclodextrin
1588:
1451:3α-hydroxysteroid dehydrogenase
1440:
1433:(5α-pregnan-3β-ol-20-one), and
1308:of less than 5%, necessitating
1291:
1132:membrane progesterone receptors
829:to a degree similar to that of
812:
788:
675:Key:AURFZBICLPNKBZ-SYBPFIFISA-N
14164:Allopregnanolone (brexanolone)
13008:Norethisterone (norethindrone)
12785:Fluoro furanyl norprogesterone
12405:15β-Hydroxycyproterone acetate
12352:Retroprogesterone derivatives:
8687:Allopregnanolone (brexanolone)
5135:3α,5α-Tetrahydrocorticosterone
4959:Progesterone (as a medication)
4655:10.1016/j.biopsych.2012.12.008
4573:10.1016/j.steroids.2004.12.007
4063:10.1016/j.psyneuen.2009.02.003
2726:10.1016/j.psyneuen.2009.07.005
2499:Chatterjee R (21 March 2019).
1655:prior to administration. Five
1532:post-traumatic stress disorder
1471:
835:altered state of consciousness
594:
582:
1:
14819:Receptor/signaling modulators
14777:Tropanyl 3,5-dimethulbenzoate
14627:Pregnenolone 16α-carbonitrile
13779:Receptor/signaling modulators
13086:11β-Methyl-19-nortestosterone
12750:17α-Methyl-19-norprogesterone
12252:Tooltip Progesterone receptor
12184:Receptor/signaling modulators
11838:Hexamethonium (benzohexonium)
11056:Receptor/signaling modulators
10997:Tooltip Glycine transporter 2
10907:Bitopertin (RG1678/RO4917838)
10884:Tooltip Glycine transporter 1
9883:Receptor/signaling modulators
8439:Ampelopsin (dihydromyricetin)
5414:3α-Androstanediol glucuronide
3264:10.1016/S0028-3908(99)00149-5
2086:Monthly Prescribing Reference
1893:10.1016/s0031-9384(02)00689-3
1807:10.1128/AEM.36.2.213-216.1978
1728:
1524:tetrahydrodeoxycorticosterone
1066:negative allosteric modulator
1015:positive allosteric modulator
750:positive allosteric modulator
14909:Pregnane X receptor agonists
13794:Estrogen receptor modulators
13789:Androgen receptor modulators
13176:Ethylestrenol (ethylnandrol)
13106:19-Nordehydroepiandrosterone
12988:Lynestrenol phenylpropionate
12881:17α-Allyl-19-nortestosterone
12780:Fluoro ethyl norprogesterone
12755:18-Methylsegesterone acetate
12655:Medroxyprogesterone caproate
12285:9α-Bromo-11-ketoprogesterone
11074:receptor positive modulators
9633:ergoloid (dihydroergotoxine)
8718:anabolic-androgenic steroids
7500:Butabarbital/Secbutabarbital
7305:receptor positive modulators
6819:Monoamine oxidase inhibitors
5103:17α,21-Dihydroxypregnenolone
4704:10.1016/j.ejphar.2010.05.033
4363:Food and Drug Administration
3586:10.1016/0896-6273(93)90156-l
3141:Masiutin M, Yadav M (2023).
3108:10.1203/PDR.0b013e3181973b0d
2450:Food and Drug Administration
2409:10.1016/j.drudis.2018.11.007
2283:Food and Drug Administration
1546:(FDA) specifically for PPD.
1544:Food and Drug Administration
1390:
1204:Biphasic actions at the GABA
1161:Similarly to many other GABA
779:Food and Drug Administration
706:, sold under the brand name
366:1-phenanthren-17-yl]ethanone
7:
14354:Dodecylbenzenesulfonic acid
14113:Tooltip Pregnane X receptor
13841:Xenobiotic-sensing receptor
13214:nandrolone phenylpropionate
13156:Dimethandrolone undecanoate
12650:Medroxyprogesterone acetate
12615:Hydroxyprogesterone acetate
12495:Chlormethenmadinone acetate
11918:Methorphan (racemethorphan)
11248:Bephenium hydroxynaphthoate
8273:Triflunordazepam (Ro5-2904)
7013:Tooltip Monoamine oxidase B
6953:Tooltip Monoamine oxidase A
6582:tetracyclic antidepressants
5484:Etiocholanolone glucuronide
5469:Dihydrotestosterone sulfate
4954:Progesterone (as a hormone)
4840:10.1016/j.ynstr.2019.100196
4208:10.1016/j.ynstr.2019.100196
2972:10.1016/j.yebeh.2008.02.004
1662:
1437:(5β-pregnan-3β-ol-20-one).
1429:(5β-pregnan-3α-ol-20-one),
841:, presyncope, fatigue, and
797:over a period of 60 hours.
781:(FDA) considers it to be a
724:of brexanolone may include
10:
14945:
12871:6,6-Difluoronorethisterone
11298:Dimethylphenylpiperazinium
10112:chlorobutanol (chloretone)
8601:5,6,7,8-Tetrahydroyangonin
6490:Dextromethorphan/bupropion
5384:16α-Hydroxyandrostenedione
5329:11β-Hydroxyandrostenedione
5314:11-Ketodihydrotestosterone
4979:Progestogen (as a hormone)
3837:10.1016/j.taap.2003.12.027
3633:10.1016/j.tips.2016.04.003
3523:Mellon SH (October 2007).
2830:10.2174/138955712802762167
2360:10.1007/s40263-019-00605-7
2160:10.1007/s40265-019-01121-0
1580:United States Adopted Name
1537:
1394:
572:Chemical and physical data
14889:Glycine receptor agonists
14810:
14106:
13850:
13771:
13751:
13695:
13670:
13552:
13397:
13276:Spirolactone derivatives:
13146:Dimethandrolone buciclate
12867:Testosterone derivatives:
12635:Mecigestone (pentarane B)
12465:Bromethenmadinone acetate
12355:20α-Dihydrodydrogesterone
12267:Progesterone derivatives:
12259:
12245:
12176:
12090:
11551:
11147:
11133:
11047:
10990:
10877:
10860:
10831:
10227:pregnenolone (eltanolone)
10204:Glutamic acid (glutamate)
9958:
9941:
9876:
9526:
9294:
9231:
9198:
9165:
9137:
8851:
8793:Pregnanolone (eltanolone)
8672:
8629:
8540:
8512:
8424:
8306:
7748:
7435:
7336:Chlorobutanol (cloretone)
7311:
7265:
7213:
7148:
7137:
7054:
7041:
7003:
6943:
6829:
6825:
6812:
6788:
6750:
6592:
6588:
6571:
6472:
6444:
6411:
6378:
6345:
6312:
6264:
6206:
6202:
6184:
6077:
6006:7β-Hydroxyepiandrosterone
6001:7α-Hydroxyepiandrosterone
5849:
5767:
5507:
5324:7β-Hydroxyepiandrosterone
5304:
5295:
5223:
5125:
5116:
5050:
4974:Progesterone vaginal ring
4946:
4604:Drug Testing and Analysis
4152:10.1007/s00213-006-0417-0
3667:Thomas P, Pang Y (2012).
3436:Journal of Neurochemistry
3017:10.1007/s10072-011-0532-5
2708:Frye CA (December 2009).
2575:10.3389/fpsyt.2021.699740
1939:10.1016/j.mce.2004.04.009
1881:Physiology & Behavior
1669:major depressive disorder
1082:ligand-gated ion channels
961:androgen backdoor pathway
783:first-in-class medication
658:
638:
616:
603:
576:
571:
539:
519:
499:
479:
459:
439:
419:
394:
374:
354:
349:
331:
318:
276:
266:
253:
245:
217:
212:
187:
171:
157:
110:
96:
78:
61:
51:
46:
37:
28:
14737:Testosterone isocaproate
14652:Reverse triiodothyronine
13429:5α-Dihydronorethisterone
13424:5α-Dihydrolevonorgestrel
13334:3,8-Dihydrodiligustilide
13101:19-Nor-5-androstenedione
13021:norethisterone enanthate
12977:levonorgestrel butanoate
12158:Phosphatidylethanolamine
11063:GABA receptor modulators
9965:Tooltip Glycine receptor
9887:GABA receptor modulators
9797:sulfonmethane (sulfonal)
7196:Rubidium chloride (RbCl)
5891:5α-Dihydrocorticosterone
5832:Pregnanediol glucuronide
5494:Testosterone glucuronide
5454:Androsterone glucuronide
5394:16α-Hydroxy-DHEA sulfate
5263:18-Hydroxycorticosterone
5215:3α,5α-Tetrahydrocortisol
5140:5α-Dihydrocorticosterone
4417:"KEGG DRUG: Brexanolone"
4097:Progress in Neurobiology
4051:Psychoneuroendocrinology
2853:Progress in Neurobiology
2714:Psychoneuroendocrinology
1633:sodium citrate dihydrate
1574:Brexanolone is both the
1569:
1375:is 1 L/h/kg. It is
1346:glucuronosyltransferases
304:glucuronosyltransferases
14129:17α-Hydroxyprogesterone
14124:17α-Hydroxypregnenolone
13723:17α-Hydroxyprogesterone
13459:Metapristone (RU-42633)
13240:Trenbolone (trienolone)
13096:19-Nor-5-androstenediol
12896:Chloroethynylnorgestrel
12810:Gestronol (gestonorone)
12740:Triamcinolone acetonide
12695:Methenmadinone caproate
12570:Fluorometholone acetate
12315:20β-Dihydroprogesterone
12310:20α-Dihydroprogesterone
12300:16α-Hydroxyprogesterone
11938:Morphanol (racemorphan)
11878:Laudexium (laudolissin)
11288:Desformylflustrabromine
10708:3β-androsterone sulfate
10704:3α-androsterone sulfate
7059:Atypical antipsychotics
6126:11β-Hydroxyprogesterone
6121:11α-Hydroxyprogesterone
5797:20β-Dihydroprogesterone
5792:20α-Dihydroprogesterone
5787:17α-Hydroxyprogesterone
5782:16α-Hydroxyprogesterone
5710:Estradiol 3-glucuronide
5190:17α-Hydroxyprogesterone
5185:17α-Hydroxypregnenolone
5093:17α-Hydroxypregnenolone
5088:11β-Hydroxypregnenolone
4324:10.1073/pnas.0606544103
3922:10.1124/jpet.110.178244
3864:Neuropsychopharmacology
3483:Molecular Endocrinology
3395:10.1124/jpet.107.127365
3147:WikiJournal of Medicine
2960:Epilepsy & Behavior
2924:10.1196/annals.1286.005
2784:10.1073/pnas.0409643102
2562:Frontiers in Psychiatry
1629:citric acid monohydrate
1360:system. The three main
1310:non-oral administration
1252:receptor PAMs, such as
1234:micronized progesterone
1114:, which does act as an
992:Allopregnanolone is an
936:, allopregnanolone and
825:(2–5%). It can produce
13708:5β-Dihydroprogesterone
13703:5α-Dihydroprogesterone
13309:SC-5233 (spirolactone)
13116:Bolandiol dipropionate
13017:norethisterone acetate
12690:Methenmadinone acetate
12485:Chlormadinone caproate
12445:Algestone acetophenide
12425:17α-Methylprogesterone
12360:20α-Dihydrotrengestone
12295:11-Deoxycorticosterone
12290:11-Dehydroprogesterone
12275:5α-Dihydroprogesterone
12270:3β-Dihydroprogesterone
10952:ORG-25935 (SCH-900435)
10141:Alkylbenzene sulfonate
9773:Retigabine (ezogabine)
9049:Lirequinil (Ro41-3696)
8616:7,8-Dihydromethysticin
8606:5,6-Dehydromethysticin
7485:Benzylbutylbarbiturate
5926:11-Deoxycorticosterone
5901:5β-Dihydroprogesterone
5896:5α-Dihydroprogesterone
5886:3β-Dihydroprogesterone
5881:3α-Dihydroprogesterone
5807:11-Deoxycorticosterone
5802:5α-Dihydroprogesterone
5444:Androstenediol sulfate
5424:5β-Dihydrotestosterone
5268:18-Hydroxyprogesterone
5248:11-Deoxycorticosterone
5145:11-Deoxycorticosterone
5098:21-Hydroxypregnenolone
4896:Clinical trial number
4884:Clinical trial number
4872:Clinical trial number
4828:Neurobiology of Stress
4737:Experimental Neurology
4196:Neurobiology of Stress
3877:10.1038/sj.npp.1301261
3496:10.1210/mend.12.9.0163
3352:Molecular Pharmacology
3319:10.1124/mol.117.108563
3307:Molecular Pharmacology
2720:(Suppl 1): S143–S161.
2532:reference.medscape.com
1855:10.1006/gcen.1996.6813
1723:traumatic brain injury
1701:progesterone, such as
1318:plasma protein binding
1314:volume of distribution
1240:Antidepressant effects
1128:5α-dihydroprogesterone
1124:5α-dihydroprogesterone
1112:5α-dihydroprogesterone
988:Molecular interactions
957:metabolic intermediate
955:Allopregnanolone is a
14904:Nicotinic antagonists
13868:6,7-Dimethylesculetin
13464:Mifepristone (RU-486)
13013:Norethisterone esters
12973:Levonorgestrel esters
12921:Ethinylandrostenediol
12725:Pentagestrone acetate
12610:Hydromadinone acetate
12480:Chlormadinone acetate
12415:17α-Bromoprogesterone
12280:6α-Methylprogesterone
12236:Progesterone receptor
12143:Glycerophosphocholine
11025:Opiranserin (VVZ-149)
10325:diethyl ether (ether)
6116:7α-Hydroxycholesterol
6096:Calcidiol/Calcifediol
5725:Estradiol 17β-sulfate
5705:Estradiol glucuronide
5625:27-Hydroxycholesterol
5233:5α-Dihydroaldosterone
5078:-Dihydroxycholesterol
4643:Biological Psychiatry
3160:10.15347/WJM/2023.003
3005:Neurological Sciences
1397:List of neurosteroids
1366:elimination half-life
1173:(L-VGCCs), including
1108:progesterone receptor
1029:receptor such as the
923:premenstrual syndrome
742:loss of consciousness
716:injection into a vein
712:postpartum depression
14455:Hypericum perforatum
14444:Hetacillin potassium
13799:List of progestogens
13299:Potassium canrenoate
13253:trenbolone enanthate
13235:Tetrahydrogestrinone
13210:nandrolone decanoate
13186:Metribolone (R-1881)
13067:Quingestanol acetate
12998:Metynodiol diacetate
12680:Melengestrol acetate
12580:Flumedroxone acetate
12525:Clomegestone acetate
12138:Dimethylethanolamine
12003:Rapacuronium bromide
11983:Pipecuronium bromide
11823:Gantacurium chloride
11783:Dizocilpine (MK-801)
11368:MEM-63,908 (RG-3487)
11318:Ethoxysebacylcholine
10720:pregnenolone sulfate
10700:Neuroactive steroids
10658:constituents (e.g.,
10618:Cyanotriphenylborate
10579:Negative modulators:
10502:N,N-Dimethylmuscimol
10428:Cyanotriphenylborate
10265:Tetrahydrocannabinol
10231:pregnenolone acetate
10219:Neuroactive steroids
10192:constituents (e.g.,
10101:Positive modulators:
9828:constituents (e.g.,
9612:Deuterated etifoxine
8674:Neuroactive steroids
8644:Apronal (apronalide)
8496:constituents (e.g.,
8113:N-Desalkylflurazepam
7180:Hypericum perforatum
7048:Adjunctive therapies
6091:7-Dehydrocholesterol
5951:Pregnenolone sulfate
5499:Testosterone sulfate
5459:Androsterone sulfate
3783:10.1210/en.2008-0774
3734:10.1210/en.2012-1772
3011:(Suppl 1): S31–S35.
2629:10.2147/DDDT.S240856
2554:"Brexanolone, a GABA
2397:Drug Discovery Today
1721:In animal models of
1716:pregnenolone sulfate
1693:neuroactive steroids
1598:controlled substance
1559:breakthrough therapy
1466:basolateral amygdala
1334:aldo-keto reductases
1301:Brexanolone has low
795:intravenous infusion
710:, and used to treat
296:aldo-keto reductases
14284:Cyproterone acetate
14184:Amlodipine besylate
12953:Etynodiol diacetate
12820:Nomegestrol acetate
12795:Gestadienol acetate
12645:Medroxyprogesterone
12545:Delmadinone acetate
12535:Cyproterone acetate
12505:Cismadinone acetate
12490:Chlormethenmadinone
12440:Algestone acetonide
12153:Phosphatidylcholine
12038:Threohydrobupropion
12023:Stercuronium iodide
11958:Pancuronium bromide
10712:deoxycorticosterone
10492:N-Methylbicuculline
9621:dihydroergocryptine
8933:Pyrazolopyrimidines
8591:5,6-Dihydroyangonin
8576:7,8-Dihydroyangonin
7763:3-Hydroxyphenazepam
7605:Methylphenobarbital
7259:Biological activity
6196:receptor modulators
6192:reuptake inhibitors
6131:Cholesterol sulfate
5866:-Hydroxycholesterol
5758:estradiol palmitate
5740:Estriol glucuronide
5730:Estrone glucuronide
5700:Estradiol disulfate
5369:Dihydrotestosterone
5354:Dehydroandrosterone
5319:11-Ketotestosterone
5155:11-Ketoprogesterone
5069:-Hydroxycholesterol
4315:2006PNAS..10314602A
4309:(39): 14602–14607.
3829:2004ToxAP.199..251L
2915:2003NYASA1007...42B
2775:2005PNAS..102.2135P
1799:1978ApEnM..36..213Y
1637:water for injection
1565:Society and culture
1156:pregnane X receptor
983:Mechanism of action
979:of the male fetus.
969:dihydrotestosterone
927:catamenial epilepsy
849:Biological function
772:γ-aminobutyric acid
690:naturally occurring
25:
14757:Thonzonium bromide
14512:Methylprednisolone
14313:prasterone sulfate
13499:Ulipristal acetate
13439:Asoprisnil ecamate
13419:Dihydroethisterone
13269:Trestolone acetate
13249:trenbolone acetate
13166:Dimethyltrienolone
12760:19-Norprogesterone
12705:Mometasone furoate
12670:Megestrol caproate
12560:Flugestone acetate
12515:Clogestone acetate
12470:Butagest (buterol)
12455:Anagestone acetate
12073:Vecuronium bromide
12013:Rocuronium bromide
11923:Methyllycaconitine
11848:Hydroxynorketamine
11743:Dextropropoxyphene
11728:Dehydronorketamine
11718:Dacuronium bromide
10922:Glycyldodecylamide
10526:4-hydroxyquinoline
10497:N-Methylstrychnine
9715:4-O-methylhonokiol
9378:Dichloralphenazone
9276:Methylmethaqualone
8853:Nonbenzodiazepines
8566:Desmethoxyyangonin
8561:11-Hydroxyyangonin
8556:11-Methoxyyangonin
8551:10-Methoxyyangonin
7938:Ethyl carfluzepate
7540:Cyclopentobarbital
7240:Never to phase III
5754:estradiol stearate
5750:Lipoidal estradiol
5680:2-Methoxyestradiol
5605:16β-Hydroxyestrone
5600:16α-Hydroxyestrone
5590:4-Methoxyestradiol
5575:4-Hydroxyestradiol
5560:2-Hydroxyestradiol
5489:Epietiocholanolone
5434:3β-Etiocholanediol
5429:3α-Etiocholanediol
5225:Mineralocorticoids
5210:5α-Dihydrocortisol
4904:ClinicalTrials.gov
4892:ClinicalTrials.gov
4880:ClinicalTrials.gov
4462:10.1111/acer.14253
4397:on 4 November 2021
4140:Psychopharmacology
3970:10.1002/glia.21049
3673:Neuroendocrinology
3095:Pediatric Research
2480:. 31 December 2019
2030:. 18 November 2019
1639:. The solution is
1621:solubilizing agent
1608:Brexanolone is an
1336:. The compound is
21:
14834:
14833:
14828:
14827:
14462:Indinavir sulfate
14169:Alpha-Lipoic acid
14144:Δ-Androstenedione
14134:Δ-Androstenedione
13807:
13806:
13767:
13766:
13666:
13665:
13245:Trenbolone esters
13206:Nandrolone esters
13161:Dimethyldienolone
12770:Amadinone acetate
12715:Osaterone acetate
12665:Megestrol acetate
12460:Bromethenmadinone
12380:Retroprogesterone
12202:
12201:
12163:Phosphorylcholine
12101:
12086:
12085:
11883:Levacetylmethadol
11763:Dihydrochandonium
11643:sodium thiopental
11313:Ethanol (alcohol)
11090:
11089:
11043:
11042:
11015:Ethanol (alcohol)
10917:Ethanol (alcohol)
10871:
10856:
10855:
10477:Isonipecotic acid
10383:2-Nitrostrychnine
10378:2-Aminostrychnine
10357:trichloroethylene
10159:sodium thiopental
10116:ethanol (alcohol)
10058:
10050:
10042:
10034:
10006:
9998:
9952:
9898:
9897:
9858:MRK-409 (MK-0343)
9629:dihydroergotamine
9572:potassium bromide
9566:compounds (e.g.,
9513:Trichloroethylene
9281:Nitromethaqualone
9200:Pyrazolopyridines
8702:3α-Androstanediol
8596:7,8-Dihydrokavain
7948:Ethyl loflazepate
7725:Thiotetrabarbital
7341:Ethanol (alcohol)
7250:
7249:
7209:
7208:
7182:(St. John's Wort)
7133:
7132:
7098:lithium carbonate
7037:
7036:
7033:
7032:
6808:
6807:
6804:
6803:
6617:Amitriptylinoxide
6567:
6566:
6563:
6562:
6139:
6138:
5976:3α-Androstanediol
5845:
5844:
5720:Estradiol sulfate
5640:4-Androstenedione
5635:3β-Androstanediol
5630:3α-Androstanediol
5419:3β-Androstanediol
5409:3α-Androstanediol
5291:
5290:
5165:21-Deoxycortisone
5007:
5006:
4649:(11): 1045–1053.
4545:978-1-934559-08-6
4391:"INN Brexanolone"
3964:(15): 1794–1805.
3685:10.1159/000339822
3252:Neuropharmacology
2824:(11): 1040–1048.
2454:. 7 February 2019
1689:ethanol addiction
1462:pyramidal neurons
1354:sulfotransferases
1098:glycine receptors
891:memory-impairment
801:Clinical efficacy
762:biological target
714:. It is given by
683:
682:
629:Interactive image
541:CompTox Dashboard
312:sulfotransferases
231:
140:
123:
73:
14936:
14894:Acetyl compounds
14851:
14850:
14849:
14842:
14747:Thiamylal sodium
14482:γ-linolenic acid
14478:α-Linolenic acid
14476:Linolenic acid:
14467:Lasalocid sodium
14457:(St John's wort)
14349:Docusate calcium
14279:Cyclophosphamide
14154:Allopregnanediol
14139:Δ-Androstenediol
14114:
14110:
14068:Ethinylestradiol
13918:Cyclophosphamide
13858:
13854:
13834:
13827:
13820:
13811:
13810:
13728:Allopregnanolone
13693:
13692:
13688:
13684:
13678:
13674:
13408:
13404:
12600:Haloprogesterone
12257:
12256:
12253:
12249:
12229:
12222:
12215:
12206:
12205:
12095:
12033:Thiocolchicoside
11843:Hydroxybupropion
11738:Dextromethorphan
11610:Allopregnanolone
11564:
11560:
11463:Suberyldicholine
11173:6-Chloronicotine
11160:
11156:
11145:
11144:
11141:
11137:
11117:
11110:
11103:
11094:
11093:
10998:
10994:
10885:
10881:
10875:
10874:
10865:
10839:
10835:
10738:dextromethorphan
10628:Dihydropyridines
10567:Thiocolchicoside
10517:Pseudostrychnine
10457:Gaboxadol (THIP)
10451:anandamide (AEA)
10443:Endocannabinoids
10175:Dihydropyridines
10135:trifluoroethanol
10131:trichloroethanol
10056:
10048:
10040:
10032:
10004:
9996:
9966:
9962:
9956:
9955:
9946:
9932:Glycine receptor
9925:
9918:
9911:
9902:
9901:
9617:Dihydroergolines
9534:3-Hydroxybutanal
9167:Piperidinediones
8900:Imidazopyridines
8434:6-Methylapigenin
8366:Hydroxyphenamate
8238:SH-053-R-CH3-2′F
7943:Ethyl dirazepate
7823:Chlordiazepoxide
7715:Thiobutabarbital
7427:Trifluoroethanol
7417:Trichloroethanol
7407:-Pentanol (2M2B)
7301:
7292:
7285:
7278:
7269:
7268:
7254:
7253:
7190:
7156:
7139:
7138:
7112:triiodothyronine
7108:Thyroid hormones
7043:
7042:
7014:
7010:
6954:
6950:
6895:Phenoxypropazine
6827:
6826:
6814:
6813:
6758:
6754:
6600:
6596:
6590:
6589:
6573:
6572:
6452:
6448:
6419:
6415:
6386:
6382:
6353:
6349:
6320:
6316:
6272:
6268:
6214:
6210:
6204:
6203:
6186:
6185:
6166:
6159:
6152:
6143:
6142:
5906:Allopregnanolone
5822:Allopregnanediol
5695:4-Methoxyestriol
5690:2-Methoxyestriol
5685:2-Methoxyestrone
5670:16α-Hydroxy-DHEA
5645:5-Androstenediol
5610:16-Ketoestradiol
5595:4-Methoxyestrone
5585:4-Hydroxyestrone
5580:4-Hydroxyestriol
5570:2-Hydroxyestrone
5565:2-Hydroxyestriol
5474:Etiocholanedione
5439:Androstanetriols
5389:16α-Hydroxy-DHEA
5302:
5301:
5243:11-Deoxycortisol
5160:21-Deoxycortisol
5150:11-Deoxycortisol
5123:
5122:
5034:
5027:
5020:
5011:
5010:
4994:Allopregnanolone
4933:
4926:
4919:
4910:
4909:
4861:
4851:
4818:
4800:
4769:
4768:
4732:
4726:
4725:
4715:
4698:(2–3): 128–134.
4683:
4677:
4676:
4666:
4634:
4628:
4627:
4599:
4593:
4592:
4556:
4550:
4549:
4529:
4523:
4522:
4493:
4484:
4483:
4473:
4441:
4435:
4434:
4427:
4421:
4420:
4413:
4407:
4406:
4404:
4402:
4393:. Archived from
4387:
4381:
4380:
4378:
4376:
4367:. 2 April 2019.
4353:
4347:
4346:
4336:
4326:
4294:
4288:
4287:
4263:
4257:
4256:
4236:
4230:
4229:
4219:
4187:
4172:
4171:
4135:
4129:
4128:
4092:
4083:
4082:
4057:(8): 1121–1132.
4046:
4037:
4036:
3999:
3990:
3989:
3953:
3944:
3943:
3933:
3901:
3890:
3889:
3879:
3870:(7): 1477–1489.
3855:
3849:
3848:
3811:
3805:
3804:
3794:
3777:(8): 3833–3844.
3762:
3756:
3755:
3745:
3713:
3707:
3706:
3696:
3664:
3655:
3654:
3644:
3612:
3606:
3605:
3569:
3563:
3562:
3552:
3520:
3509:
3508:
3498:
3489:(9): 1441–1451.
3474:
3468:
3467:
3442:(6): 2412–2423.
3431:
3425:
3424:
3406:
3374:
3368:
3367:
3347:
3341:
3340:
3330:
3290:
3284:
3283:
3247:
3241:
3240:
3231:(3): 1223–1229.
3220:
3214:
3213:
3179:
3173:
3172:
3162:
3138:
3132:
3131:
3110:
3086:
3080:
3079:
3043:
3037:
3036:
3000:
2994:
2993:
2983:
2951:
2945:
2944:
2926:
2894:
2885:
2884:
2848:
2842:
2841:
2813:
2807:
2806:
2796:
2786:
2769:(6): 2135–2140.
2754:
2748:
2747:
2737:
2705:
2696:
2695:
2658:
2652:
2651:
2641:
2631:
2607:
2598:
2597:
2587:
2577:
2549:
2543:
2542:
2540:
2538:
2524:
2518:
2517:
2515:
2513:
2496:
2490:
2489:
2487:
2485:
2470:
2464:
2463:
2461:
2459:
2440:
2431:
2430:
2420:
2388:
2382:
2381:
2371:
2339:
2333:
2332:
2330:
2328:
2317:
2311:
2305:
2304:
2300:
2298:
2296:
2273:
2246:
2245:
2235:
2201:
2180:
2179:
2143:
2102:
2101:
2099:
2097:
2088:. 17 June 2019.
2078:
2069:
2068:
2066:
2064:
2054:nctr-crs.fda.gov
2046:
2040:
2039:
2037:
2035:
2018:
1959:
1958:
1933:(1–2): 113–120.
1922:
1913:
1912:
1876:
1867:
1866:
1838:
1829:
1828:
1818:
1778:
1769:
1768:
1766:
1742:
1677:essential tremor
1297:Pharmacokinetics
1152:antigonadotropic
1084:, including the
940:are involved in
769:neurotransmitter
686:Allopregnanolone
631:
611:
596:
590:
584:
564:
563:
549:
547:
532:
512:
492:
472:
452:
432:
412:
402:
401:
387:
323:
236:
229:
226:
204:
150:
139:
136:
133:
122:
119:
106:
92:
72:
69:
42:
33:
26:
24:
23:Allopregnanolone
20:
14944:
14943:
14939:
14938:
14937:
14935:
14934:
14933:
14874:Antidepressants
14869:Anticonvulsants
14859:
14858:
14857:
14847:
14845:
14837:
14835:
14830:
14829:
14824:
14806:
14707:Suberoylanilide
14424:Fluorometholone
14319:Dibunate sodium
14199:Aurothioglucose
14112:
14102:
14038:3,17β-Estradiol
13856:
13846:
13838:
13808:
13803:
13763:
13747:
13686:
13679:
13676:
13662:
13548:
13406:
13399:
13393:
13220:Norethandrolone
13181:Methyldienolone
13141:Dimethandrolone
12565:Fluorometholone
12251:
12241:
12233:
12203:
12198:
12172:
12094:
12082:
11688:Chlorisondamine
11562:
11555:
11547:
11158:
11151:
11139:
11129:
11121:
11091:
11086:
11073:
11039:
10996:
10986:
10897:ALX-5407 (NFPS)
10883:
10864:
10852:
10837:
10827:
10587:Benzodiazepines
10472:Isobutyric acid
10313:chloral hydrate
10165:Chlormethiazole
10127:tribromoethanol
10123:-butanol (2M2P)
9964:
9945:
9937:
9929:
9899:
9894:
9872:
9830:isovaleric acid
9793:Sulfonylalkanes
9691:Hopantenic acid
9675:tolfenamic acid
9663:flufenamic acid
9625:dihydroergosine
9568:lithium bromide
9527:Others/unsorted
9522:
9383:Dichloromethane
9358:Chloral hydrate
9353:Chloral betaine
9290:
9227:
9194:
9161:
9133:
8862:Cyclopyrrolones
8847:
8753:Etiocholanolone
8668:
8625:
8586:5-Hydroxykavain
8536:
8508:
8420:
8302:
7750:Benzodiazepines
7744:
7555:Ethallobarbital
7550:Enallylpropymal
7431:
7412:Tribromoethanol
7399:-Butanol (2M2P)
7345:alcoholic drink
7307:
7304:
7296:
7261:
7251:
7246:
7245:
7230:Clinical trials
7205:
7144:
7129:
7125:
7117:
7102:lithium citrate
7050:
7029:
7012:
7009:
6999:
6952:
6949:
6939:
6915:Tranylcypromine
6821:
6800:
6784:
6756:
6746:
6598:
6584:
6559:
6468:
6450:
6440:
6417:
6407:
6384:
6374:
6351:
6341:
6318:
6308:
6289:Levomilnacipran
6270:
6260:
6212:
6198:
6180:
6173:Antidepressants
6170:
6140:
6135:
6106:Cholecalciferol
6073:
6054:Androstadienone
6026:Etiocholanolone
5996:7β-Hydroxy-DHEA
5991:7α-Hydroxy-DHEA
5936:Isopregnanolone
5931:Epipregnanolone
5841:
5763:
5745:Estriol sulfate
5735:Estrone sulfate
5665:7α-Hydroxy-DHEA
5503:
5479:Etiocholanolone
5449:Androstenetriol
5379:Epitestosterone
5374:Epiandrosterone
5344:Androstenedione
5287:
5219:
5127:Glucocorticoids
5118:Corticosteroids
5112:
5046:
5038:
5008:
5003:
4942:
4937:
4869:
4864:
4778:
4776:Further reading
4773:
4772:
4733:
4729:
4684:
4680:
4635:
4631:
4616:10.1002/dta.281
4600:
4596:
4557:
4553:
4546:
4530:
4526:
4494:
4487:
4442:
4438:
4429:
4428:
4424:
4415:
4414:
4410:
4400:
4398:
4389:
4388:
4384:
4374:
4372:
4355:
4354:
4350:
4295:
4291:
4264:
4260:
4237:
4233:
4188:
4175:
4136:
4132:
4093:
4086:
4047:
4040:
4000:
3993:
3954:
3947:
3902:
3893:
3856:
3852:
3812:
3808:
3763:
3759:
3714:
3710:
3665:
3658:
3613:
3609:
3570:
3566:
3521:
3512:
3475:
3471:
3432:
3428:
3375:
3371:
3348:
3344:
3302:
3298:
3291:
3287:
3248:
3244:
3221:
3217:
3202:
3180:
3176:
3139:
3135:
3087:
3083:
3044:
3040:
3001:
2997:
2952:
2948:
2895:
2888:
2849:
2845:
2814:
2810:
2755:
2751:
2706:
2699:
2659:
2655:
2608:
2601:
2557:
2550:
2546:
2536:
2534:
2526:
2525:
2521:
2511:
2509:
2497:
2493:
2483:
2481:
2472:
2471:
2467:
2457:
2455:
2442:
2441:
2434:
2389:
2385:
2340:
2336:
2326:
2324:
2319:
2318:
2314:
2302:
2294:
2292:
2275:
2274:
2249:
2224:
2202:
2183:
2144:
2105:
2095:
2093:
2080:
2079:
2072:
2062:
2060:
2048:
2047:
2043:
2033:
2031:
2020:
2019:
1962:
1923:
1916:
1877:
1870:
1839:
1832:
1779:
1772:
1743:
1736:
1731:
1665:
1653:sodium chloride
1631:, 2.57 mg
1606:
1604:Available forms
1591:
1572:
1567:
1555:priority review
1540:
1474:
1443:
1435:epipregnanolone
1431:isopregnanolone
1399:
1393:
1358:cytochrome P450
1342:glucuronidation
1306:bioavailability
1299:
1294:
1279:
1275:
1271:
1267:
1263:
1254:benzodiazepines
1251:
1247:
1242:
1231:
1223:
1210:
1207:
1193:
1185:
1178:
1164:
1149:
1077:
1061:
1051:
1047:
1040:
1036:
1031:benzodiazepines
1028:
1022:
990:
985:
907:neuroprotective
863:stress-reducing
851:
815:
803:
791:
757:
679:
676:
671:
666:
665:
654:
651:
646:
645:
634:
609:
599:
593:
587:
567:
543:
535:
515:
495:
475:
455:
435:
415:
398:
390:
370:
367:
362:
361:
341:
321:
300:glucuronidation
268:Protein binding
255:Bioavailability
247:Pharmacokinetic
241:
234:
208:
182:Antidepressants
160:
153:
17:
12:
11:
5:
14942:
14932:
14931:
14926:
14921:
14916:
14911:
14906:
14901:
14896:
14891:
14886:
14881:
14876:
14871:
14856:
14855:
14832:
14831:
14826:
14825:
14823:
14822:
14815:
14811:
14808:
14807:
14805:
14804:
14799:
14790:
14789:
14784:
14779:
14774:
14772:Troleandomycin
14769:
14764:
14759:
14754:
14749:
14744:
14739:
14734:
14729:
14724:
14719:
14714:
14709:
14704:
14699:
14694:
14692:Spironolactone
14689:
14684:
14679:
14674:
14669:
14664:
14659:
14654:
14649:
14644:
14639:
14634:
14629:
14624:
14619:
14614:
14609:
14604:
14599:
14594:
14589:
14584:
14579:
14574:
14569:
14564:
14562:Norelgestromin
14559:
14554:
14549:
14544:
14539:
14534:
14529:
14524:
14519:
14514:
14509:
14504:
14499:
14494:
14489:
14484:
14474:
14469:
14464:
14459:
14451:
14446:
14441:
14436:
14431:
14426:
14421:
14419:Flucloxacillin
14416:
14411:
14406:
14401:
14396:
14391:
14386:
14381:
14376:
14371:
14366:
14361:
14356:
14351:
14346:
14341:
14336:
14331:
14326:
14321:
14316:
14306:
14296:
14291:
14286:
14281:
14276:
14274:Corticosterone
14271:
14266:
14261:
14256:
14251:
14246:
14241:
14239:Chlorpromazine
14236:
14231:
14226:
14221:
14216:
14211:
14206:
14201:
14196:
14191:
14186:
14181:
14176:
14171:
14166:
14161:
14156:
14151:
14146:
14141:
14136:
14131:
14126:
14117:
14115:
14104:
14103:
14101:
14100:
14095:
14090:
14085:
14080:
14075:
14070:
14065:
14060:
14058:17-Androstanol
14055:
14053:3β-Androstanol
14050:
14048:3α-Androstenol
14045:
14043:3α-Androstanol
14040:
14031:
14030:
14025:
14020:
14015:
14010:
14005:
14000:
13995:
13990:
13985:
13980:
13975:
13970:
13965:
13960:
13955:
13950:
13945:
13940:
13935:
13925:
13920:
13915:
13910:
13905:
13900:
13898:Chlorpromazine
13895:
13890:
13885:
13880:
13875:
13870:
13861:
13859:
13848:
13847:
13837:
13836:
13829:
13822:
13814:
13805:
13804:
13802:
13801:
13796:
13791:
13786:
13781:
13776:
13772:
13769:
13768:
13765:
13764:
13762:
13761:
13755:
13753:
13749:
13748:
13746:
13745:
13740:
13735:
13730:
13725:
13720:
13715:
13710:
13705:
13699:
13697:
13690:
13668:
13667:
13664:
13663:
13661:
13660:
13655:
13650:
13645:
13640:
13635:
13630:
13625:
13620:
13611:
13610:
13605:
13600:
13595:
13590:
13585:
13580:
13575:
13570:
13565:
13556:
13554:
13550:
13549:
13547:
13546:
13541:
13536:
13531:
13526:
13521:
13512:
13511:
13506:
13501:
13496:
13491:
13486:
13481:
13476:
13471:
13466:
13461:
13456:
13451:
13446:
13441:
13436:
13431:
13426:
13421:
13412:
13410:
13395:
13394:
13392:
13391:
13386:
13377:
13376:
13371:
13366:
13361:
13356:
13351:
13346:
13341:
13336:
13327:
13326:
13321:
13319:Spironolactone
13316:
13311:
13306:
13301:
13296:
13291:
13286:
13281:
13279:Canrenoic acid
13272:
13271:
13266:
13261:
13256:
13242:
13237:
13232:
13227:
13222:
13217:
13203:
13198:
13193:
13188:
13183:
13178:
13173:
13171:Ethyldienolone
13168:
13163:
13158:
13153:
13148:
13143:
13138:
13133:
13128:
13126:Dimethisterone
13123:
13118:
13113:
13108:
13103:
13098:
13093:
13088:
13079:
13074:
13069:
13064:
13059:
13054:
13052:Norvinisterone
13049:
13047:Norgestrienone
13044:
13039:
13034:
13029:
13024:
13010:
13005:
13003:Norelgestromin
13000:
12995:
12990:
12985:
12980:
12970:
12968:Levonorgestrel
12965:
12960:
12955:
12950:
12945:
12940:
12935:
12930:
12929:
12928:
12918:
12913:
12908:
12903:
12898:
12893:
12888:
12883:
12878:
12873:
12863:
12862:
12857:
12852:
12847:
12842:
12837:
12832:
12827:
12822:
12817:
12812:
12807:
12802:
12797:
12792:
12787:
12782:
12777:
12772:
12767:
12762:
12757:
12752:
12743:
12742:
12737:
12732:
12727:
12722:
12717:
12712:
12707:
12702:
12697:
12692:
12687:
12685:Methenmadinone
12682:
12677:
12672:
12667:
12662:
12657:
12652:
12647:
12642:
12637:
12632:
12627:
12622:
12617:
12612:
12607:
12602:
12597:
12592:
12587:
12582:
12577:
12572:
12567:
12562:
12557:
12552:
12547:
12542:
12537:
12532:
12527:
12522:
12517:
12512:
12507:
12502:
12497:
12492:
12487:
12482:
12477:
12472:
12467:
12462:
12457:
12452:
12447:
12442:
12437:
12432:
12427:
12422:
12417:
12412:
12407:
12402:
12393:
12392:
12387:
12382:
12377:
12375:Dydrogesterone
12372:
12367:
12362:
12357:
12348:
12347:
12342:
12337:
12332:
12327:
12322:
12317:
12312:
12307:
12302:
12297:
12292:
12287:
12282:
12277:
12272:
12263:
12261:
12254:
12243:
12242:
12232:
12231:
12224:
12217:
12209:
12200:
12199:
12197:
12196:
12191:
12186:
12181:
12177:
12174:
12173:
12171:
12170:
12165:
12160:
12155:
12150:
12145:
12140:
12135:
12130:
12125:
12115:
12110:
12104:
12102:
12088:
12087:
12084:
12083:
12081:
12080:
12075:
12070:
12065:
12060:
12055:
12050:
12045:
12040:
12035:
12030:
12025:
12020:
12015:
12010:
12005:
12000:
11995:
11990:
11985:
11980:
11975:
11970:
11965:
11960:
11955:
11950:
11945:
11940:
11935:
11930:
11925:
11920:
11915:
11910:
11905:
11900:
11895:
11890:
11885:
11880:
11875:
11870:
11868:Kynurenic acid
11865:
11860:
11855:
11850:
11845:
11840:
11835:
11830:
11825:
11820:
11815:
11810:
11805:
11800:
11795:
11790:
11785:
11780:
11775:
11770:
11765:
11760:
11755:
11750:
11745:
11740:
11735:
11730:
11725:
11720:
11715:
11710:
11705:
11700:
11695:
11690:
11685:
11680:
11675:
11670:
11665:
11662:κ-bungarotoxin
11658:α-bungarotoxin
11651:
11646:
11632:
11627:
11622:
11617:
11612:
11607:
11602:
11597:
11596:, many others)
11586:α-bungarotoxin
11579:
11574:
11568:
11566:
11549:
11548:
11546:
11545:
11540:
11535:
11530:
11525:
11520:
11518:Tribendimidine
11515:
11510:
11505:
11500:
11495:
11490:
11485:
11480:
11475:
11470:
11465:
11460:
11455:
11450:
11445:
11443:Sebacylcholine
11440:
11435:
11430:
11425:
11420:
11415:
11410:
11405:
11400:
11395:
11390:
11385:
11375:
11370:
11365:
11360:
11355:
11350:
11345:
11340:
11335:
11330:
11325:
11320:
11315:
11310:
11305:
11300:
11295:
11290:
11285:
11280:
11275:
11270:
11265:
11260:
11258:Butyrylcholine
11255:
11250:
11245:
11240:
11235:
11230:
11225:
11220:
11215:
11210:
11205:
11200:
11195:
11190:
11185:
11180:
11175:
11170:
11164:
11162:
11142:
11131:
11130:
11120:
11119:
11112:
11105:
11097:
11088:
11087:
11085:
11084:
11077:
11071:
11066:
11059:
11052:
11048:
11045:
11044:
11041:
11040:
11038:
11037:
11032:
11027:
11022:
11017:
11012:
11007:
11001:
10999:
10988:
10987:
10985:
10984:
10979:
10974:
10969:
10964:
10959:
10954:
10949:
10944:
10939:
10934:
10929:
10924:
10919:
10914:
10909:
10904:
10899:
10894:
10888:
10886:
10872:
10858:
10857:
10854:
10853:
10851:
10850:
10842:
10840:
10829:
10828:
10826:
10825:
10820:
10815:
10793:
10788:
10783:
10769:
10727:
10697:
10692:
10687:
10653:
10648:
10643:
10625:
10620:
10615:
10610:
10584:
10575:
10574:
10569:
10564:
10559:
10554:
10549:
10519:
10514:
10509:
10507:Nipecotic acid
10504:
10499:
10494:
10489:
10484:
10479:
10474:
10469:
10464:
10459:
10454:
10440:
10435:
10430:
10425:
10420:
10415:
10410:
10405:
10400:
10395:
10390:
10385:
10380:
10371:
10370:
10365:
10360:
10341:methoxyflurane
10302:
10272:
10267:
10262:
10257:
10252:
10247:
10242:
10216:
10211:
10206:
10201:
10198:ginsenoside-Rf
10187:
10182:
10172:
10167:
10162:
10148:
10143:
10138:
10097:
10096:
10091:
10086:
10081:
10076:
10074:Picolinic acid
10071:
10066:
10061:
10053:
10045:
10037:
10029:
10024:
10019:
10014:
10009:
10001:
9993:
9988:
9983:
9978:
9969:
9967:
9953:
9939:
9938:
9928:
9927:
9920:
9913:
9905:
9896:
9895:
9877:
9874:
9873:
9871:
9870:
9865:
9860:
9855:
9846:
9845:
9838:valerenic acid
9823:
9818:
9808:
9790:
9785:
9780:
9775:
9770:
9765:
9760:
9755:
9750:
9745:
9740:
9735:
9730:
9708:
9703:
9698:
9693:
9688:
9683:
9678:
9667:mefenamic acid
9656:
9651:
9646:
9641:
9636:
9614:
9609:
9604:
9599:
9594:
9589:
9584:
9579:
9576:sodium bromide
9561:
9551:
9546:
9541:
9536:
9530:
9528:
9524:
9523:
9521:
9520:
9515:
9510:
9505:
9500:
9495:
9490:
9485:
9480:
9475:
9470:
9465:
9460:
9455:
9450:
9445:
9443:Methoxypropane
9440:
9438:Methoxyflurane
9435:
9430:
9425:
9420:
9415:
9410:
9405:
9400:
9398:Ethyl chloride
9395:
9390:
9385:
9380:
9375:
9370:
9365:
9360:
9355:
9350:
9345:
9340:
9335:
9330:
9325:
9320:
9315:
9310:
9304:
9302:
9292:
9291:
9289:
9288:
9283:
9278:
9273:
9268:
9263:
9258:
9253:
9248:
9243:
9237:
9235:
9233:Quinazolinones
9229:
9228:
9226:
9225:
9220:
9215:
9210:
9204:
9202:
9196:
9195:
9193:
9192:
9187:
9182:
9177:
9171:
9169:
9163:
9162:
9160:
9159:
9154:
9149:
9143:
9141:
9135:
9134:
9132:
9131:
9126:
9121:
9116:
9111:
9106:
9101:
9096:
9091:
9086:
9081:
9076:
9071:
9066:
9061:
9056:
9051:
9046:
9041:
9036:
9031:
9026:
9021:
9016:
9011:
9006:
9001:
8996:
8991:
8986:
8976:
8975:
8970:
8965:
8960:
8955:
8950:
8945:
8940:
8928:
8927:
8922:
8917:
8912:
8907:
8895:
8894:
8889:
8884:
8879:
8874:
8869:
8857:
8855:
8849:
8848:
8846:
8845:
8840:
8835:
8830:
8825:
8820:
8815:
8810:
8805:
8800:
8795:
8790:
8785:
8780:
8775:
8770:
8765:
8760:
8755:
8750:
8745:
8740:
8735:
8730:
8725:
8720:
8714:
8709:
8704:
8699:
8694:
8689:
8684:
8678:
8676:
8670:
8669:
8667:
8666:
8661:
8656:
8651:
8646:
8641:
8635:
8633:
8627:
8626:
8624:
8623:
8618:
8613:
8608:
8603:
8598:
8593:
8588:
8583:
8578:
8573:
8568:
8563:
8558:
8553:
8547:
8545:
8538:
8537:
8535:
8534:
8529:
8524:
8518:
8516:
8510:
8509:
8507:
8506:
8501:
8491:
8486:
8481:
8476:
8471:
8466:
8461:
8456:
8451:
8446:
8441:
8436:
8430:
8428:
8422:
8421:
8419:
8418:
8413:
8408:
8403:
8398:
8393:
8388:
8383:
8378:
8373:
8368:
8363:
8358:
8353:
8348:
8343:
8338:
8333:
8328:
8323:
8318:
8312:
8310:
8304:
8303:
8301:
8300:
8295:
8290:
8285:
8280:
8275:
8270:
8265:
8260:
8255:
8250:
8245:
8240:
8235:
8230:
8225:
8220:
8215:
8210:
8205:
8200:
8195:
8190:
8185:
8180:
8175:
8170:
8165:
8160:
8155:
8150:
8145:
8140:
8135:
8130:
8125:
8120:
8115:
8110:
8105:
8100:
8095:
8090:
8085:
8080:
8075:
8070:
8065:
8060:
8055:
8050:
8045:
8040:
8035:
8030:
8025:
8020:
8015:
8010:
8005:
8000:
7995:
7990:
7985:
7980:
7975:
7970:
7965:
7960:
7955:
7950:
7945:
7940:
7935:
7930:
7925:
7920:
7915:
7910:
7905:
7900:
7895:
7890:
7885:
7880:
7875:
7870:
7865:
7860:
7855:
7850:
7845:
7840:
7835:
7830:
7825:
7820:
7815:
7810:
7805:
7800:
7795:
7790:
7785:
7780:
7775:
7770:
7765:
7760:
7754:
7752:
7746:
7745:
7743:
7742:
7737:
7732:
7727:
7722:
7717:
7712:
7707:
7702:
7697:
7692:
7687:
7682:
7677:
7672:
7667:
7662:
7657:
7655:Propylbarbital
7652:
7647:
7642:
7637:
7632:
7627:
7622:
7617:
7612:
7607:
7602:
7597:
7592:
7587:
7582:
7577:
7572:
7567:
7562:
7557:
7552:
7547:
7542:
7537:
7532:
7530:Crotylbarbital
7527:
7522:
7517:
7512:
7507:
7502:
7497:
7495:Brophebarbital
7492:
7490:Brallobarbital
7487:
7482:
7477:
7472:
7467:
7462:
7457:
7452:
7447:
7441:
7439:
7433:
7432:
7430:
7429:
7424:
7419:
7414:
7409:
7401:
7393:
7388:
7383:
7378:
7376:Methylpentynol
7373:
7368:
7363:
7358:
7353:
7348:
7338:
7333:
7328:
7323:
7317:
7315:
7309:
7308:
7302:
7295:
7294:
7287:
7280:
7272:
7266:
7263:
7262:
7248:
7247:
7244:
7243:
7242:
7241:
7238:
7227:
7221:
7215:
7214:
7211:
7210:
7207:
7206:
7204:
7203:
7198:
7193:
7184:
7176:
7159:
7153:Ademetionine (
7149:
7146:
7145:
7135:
7134:
7131:
7130:
7128:
7127:
7123:
7115:
7105:
7091:
7086:
7055:
7052:
7051:
7039:
7038:
7035:
7034:
7031:
7030:
7028:
7027:
7018:
7016:
7007:
7001:
7000:
6998:
6997:
6992:
6987:
6982:
6977:
6972:
6967:
6958:
6956:
6947:
6941:
6940:
6938:
6937:
6928:
6927:
6918:
6917:
6912:
6907:
6902:
6897:
6892:
6887:
6882:
6877:
6872:
6867:
6862:
6857:
6852:
6847:
6842:
6833:
6831:
6823:
6822:
6810:
6809:
6806:
6805:
6802:
6801:
6799:
6798:
6792:
6790:
6786:
6785:
6783:
6782:
6777:
6772:
6767:
6761:
6759:
6748:
6747:
6745:
6744:
6739:
6734:
6729:
6724:
6719:
6714:
6709:
6704:
6699:
6694:
6689:
6684:
6679:
6674:
6672:Imipraminoxide
6669:
6664:
6659:
6654:
6649:
6644:
6639:
6634:
6629:
6624:
6619:
6614:
6609:
6603:
6601:
6586:
6585:
6569:
6568:
6565:
6564:
6561:
6560:
6558:
6557:
6552:
6547:
6542:
6537:
6532:
6527:
6522:
6517:
6512:
6507:
6502:
6497:
6492:
6487:
6482:
6476:
6474:
6470:
6469:
6467:
6466:
6461:
6455:
6453:
6442:
6441:
6439:
6438:
6433:
6428:
6422:
6420:
6409:
6408:
6406:
6405:
6400:
6395:
6389:
6387:
6376:
6375:
6373:
6372:
6367:
6362:
6356:
6354:
6343:
6342:
6340:
6339:
6334:
6329:
6323:
6321:
6310:
6309:
6307:
6306:
6301:
6296:
6291:
6286:
6281:
6279:Desvenlafaxine
6275:
6273:
6262:
6261:
6259:
6258:
6253:
6248:
6243:
6238:
6233:
6228:
6223:
6217:
6215:
6200:
6199:
6182:
6181:
6169:
6168:
6161:
6154:
6146:
6137:
6136:
6134:
6133:
6128:
6123:
6118:
6109:
6108:
6103:
6098:
6093:
6081:
6079:
6075:
6074:
6072:
6071:
6069:Estratetraenol
6066:
6061:
6056:
6051:
6049:Androstadienol
6046:
6044:3β-Androstenol
6041:
6039:3α-Androstenol
6029:
6028:
6023:
6018:
6013:
6008:
6003:
5998:
5993:
5988:
5983:
5981:3α-Androstenol
5978:
5969:
5968:
5963:
5958:
5953:
5948:
5943:
5938:
5933:
5928:
5923:
5918:
5913:
5911:Corticosterone
5908:
5903:
5898:
5893:
5888:
5883:
5874:
5873:
5868:
5855:
5853:
5847:
5846:
5843:
5842:
5840:
5839:
5834:
5829:
5824:
5815:
5814:
5809:
5804:
5799:
5794:
5789:
5784:
5779:
5773:
5771:
5765:
5764:
5762:
5761:
5747:
5742:
5737:
5732:
5727:
5722:
5717:
5712:
5707:
5702:
5697:
5692:
5687:
5682:
5673:
5672:
5667:
5662:
5657:
5652:
5647:
5642:
5637:
5632:
5627:
5618:
5617:
5615:16-Ketoestrone
5612:
5607:
5602:
5597:
5592:
5587:
5582:
5577:
5572:
5567:
5562:
5557:
5552:
5547:
5542:
5537:
5532:
5527:
5522:
5513:
5511:
5505:
5504:
5502:
5501:
5496:
5491:
5486:
5481:
5476:
5471:
5466:
5461:
5456:
5451:
5446:
5441:
5436:
5431:
5426:
5421:
5416:
5411:
5402:
5401:
5396:
5391:
5386:
5381:
5376:
5371:
5366:
5361:
5356:
5351:
5346:
5341:
5339:Androstenediol
5336:
5331:
5326:
5321:
5316:
5310:
5308:
5299:
5293:
5292:
5289:
5288:
5286:
5285:
5280:
5278:Corticosterone
5275:
5270:
5265:
5260:
5255:
5250:
5245:
5240:
5235:
5229:
5227:
5221:
5220:
5218:
5217:
5212:
5203:
5202:
5197:
5192:
5187:
5182:
5177:
5172:
5170:Corticosterone
5167:
5162:
5157:
5152:
5147:
5142:
5137:
5131:
5129:
5120:
5114:
5113:
5111:
5110:
5105:
5100:
5095:
5090:
5085:
5080:
5071:
5062:
5056:
5054:
5048:
5047:
5037:
5036:
5029:
5022:
5014:
5005:
5004:
5002:
5001:
4996:
4991:
4986:
4981:
4976:
4971:
4966:
4961:
4956:
4950:
4948:
4944:
4943:
4936:
4935:
4928:
4921:
4913:
4907:
4906:
4894:
4882:
4868:
4867:External links
4865:
4863:
4862:
4819:
4779:
4777:
4774:
4771:
4770:
4743:(2): 404–412.
4727:
4678:
4629:
4610:(5): 283–290.
4594:
4567:(3): 179–183.
4551:
4544:
4524:
4505:(3): 238–244.
4485:
4456:(2): 320–339.
4436:
4433:. AdisInsight.
4422:
4408:
4382:
4348:
4289:
4258:
4247:(4): 148–150.
4231:
4173:
4146:(2): 209–221.
4130:
4084:
4038:
3991:
3945:
3916:(1): 301–311.
3891:
3850:
3823:(3): 251–265.
3806:
3757:
3728:(1): 283–295.
3708:
3679:(2): 162–171.
3656:
3627:(7): 543–561.
3607:
3580:(3): 523–530.
3564:
3535:(1): 107–124.
3510:
3469:
3426:
3389:(1): 236–247.
3369:
3358:(4): 752–759.
3342:
3300:
3296:
3285:
3258:(3): 440–448.
3242:
3215:
3200:
3174:
3133:
3101:(3): 255–260.
3081:
3054:(3): 455–471.
3038:
2995:
2946:
2886:
2843:
2808:
2749:
2697:
2670:(1): 169–173.
2653:
2599:
2555:
2544:
2519:
2491:
2465:
2432:
2403:(2): 606–615.
2383:
2354:(3): 265–282.
2334:
2312:
2247:
2222:
2181:
2154:(7): 779–783.
2103:
2070:
2041:
1960:
1914:
1887:(1): 151–158.
1868:
1849:(2): 164–167.
1830:
1793:(2): 213–216.
1770:
1751:Anesthesiology
1733:
1732:
1730:
1727:
1664:
1661:
1605:
1602:
1590:
1587:
1571:
1568:
1566:
1563:
1539:
1536:
1473:
1470:
1453:converts this
1449:. After that,
1442:
1439:
1415:4-pregnenolone
1407:5-pregnenolone
1392:
1389:
1298:
1295:
1293:
1290:
1277:
1273:
1269:
1265:
1261:
1249:
1245:
1241:
1238:
1229:
1221:
1209:
1205:
1202:
1191:
1183:
1176:
1162:
1147:
1075:
1070:nACh receptors
1059:
1049:
1045:
1038:
1034:
1026:
1020:
989:
986:
984:
981:
903:anticonvulsant
875:antiaggressive
855:antidepressant
850:
847:
814:
811:
802:
799:
790:
787:
755:
748:and acts as a
681:
680:
678:
677:
674:
672:
669:
661:
660:
659:
656:
655:
653:
652:
649:
641:
640:
639:
636:
635:
633:
632:
624:
622:
614:
613:
607:
601:
600:
597:
591:
585:
580:
574:
573:
569:
568:
566:
565:
552:
550:
537:
536:
534:
533:
525:
523:
517:
516:
514:
513:
505:
503:
497:
496:
494:
493:
485:
483:
477:
476:
474:
473:
465:
463:
457:
456:
454:
453:
445:
443:
437:
436:
434:
433:
425:
423:
417:
416:
414:
413:
405:
403:
392:
391:
389:
388:
380:
378:
372:
371:
369:
368:
365:
357:
356:
355:
352:
351:
347:
346:
335:
329:
328:
325:
316:
315:
280:
274:
273:
270:
264:
263:
257:
251:
250:
243:
242:
240:
239:
223:
221:
215:
214:
210:
209:
207:
206:
193:
191:
185:
184:
175:
169:
168:
163:
161:administration
155:
154:
152:
151:
134:
116:
114:
108:
107:
100:
94:
93:
86:
76:
75:
63:
59:
58:
55:
49:
48:
44:
43:
35:
34:
15:
9:
6:
4:
3:
2:
14941:
14930:
14927:
14925:
14922:
14920:
14917:
14915:
14912:
14910:
14907:
14905:
14902:
14900:
14899:Neurosteroids
14897:
14895:
14892:
14890:
14887:
14885:
14882:
14880:
14877:
14875:
14872:
14870:
14867:
14866:
14864:
14854:
14844:
14843:
14840:
14821:
14820:
14816:
14813:
14812:
14809:
14803:
14800:
14798:
14795:
14792:
14791:
14788:
14785:
14783:
14780:
14778:
14775:
14773:
14770:
14768:
14765:
14763:
14760:
14758:
14755:
14753:
14750:
14748:
14745:
14743:
14740:
14738:
14735:
14733:
14730:
14728:
14725:
14723:
14720:
14718:
14715:
14713:
14712:Sulfisoxazole
14710:
14708:
14705:
14703:
14700:
14698:
14695:
14693:
14690:
14688:
14685:
14683:
14680:
14678:
14675:
14673:
14670:
14668:
14665:
14663:
14660:
14658:
14655:
14653:
14650:
14648:
14645:
14643:
14640:
14638:
14635:
14633:
14630:
14628:
14625:
14623:
14620:
14618:
14615:
14613:
14610:
14608:
14605:
14603:
14600:
14598:
14595:
14593:
14590:
14588:
14587:Phenobarbital
14585:
14583:
14580:
14578:
14575:
14573:
14570:
14568:
14565:
14563:
14560:
14558:
14555:
14553:
14550:
14548:
14545:
14543:
14540:
14538:
14535:
14533:
14530:
14528:
14525:
14523:
14520:
14518:
14515:
14513:
14510:
14508:
14505:
14503:
14500:
14498:
14495:
14493:
14490:
14488:
14485:
14483:
14479:
14475:
14473:
14472:Levothyroxine
14470:
14468:
14465:
14463:
14460:
14458:
14456:
14452:
14450:
14447:
14445:
14442:
14440:
14437:
14435:
14434:Guggulsterone
14432:
14430:
14427:
14425:
14422:
14420:
14417:
14415:
14412:
14410:
14407:
14405:
14402:
14400:
14397:
14395:
14392:
14390:
14387:
14385:
14382:
14380:
14377:
14375:
14372:
14370:
14367:
14365:
14362:
14360:
14357:
14355:
14352:
14350:
14347:
14345:
14342:
14340:
14337:
14335:
14332:
14330:
14329:Dicloxacillin
14327:
14325:
14322:
14320:
14317:
14314:
14310:
14307:
14304:
14300:
14297:
14295:
14294:Dexamethasone
14292:
14290:
14287:
14285:
14282:
14280:
14277:
14275:
14272:
14270:
14267:
14265:
14262:
14260:
14257:
14255:
14252:
14250:
14247:
14245:
14242:
14240:
14237:
14235:
14232:
14230:
14229:Cephaloridine
14227:
14225:
14222:
14220:
14217:
14215:
14212:
14210:
14207:
14205:
14202:
14200:
14197:
14195:
14192:
14190:
14187:
14185:
14182:
14180:
14177:
14175:
14172:
14170:
14167:
14165:
14162:
14160:
14157:
14155:
14152:
14150:
14147:
14145:
14142:
14140:
14137:
14135:
14132:
14130:
14127:
14125:
14122:
14119:
14118:
14116:
14111:
14105:
14099:
14096:
14094:
14091:
14089:
14086:
14084:
14081:
14079:
14076:
14074:
14071:
14069:
14066:
14064:
14061:
14059:
14056:
14054:
14051:
14049:
14046:
14044:
14041:
14039:
14036:
14033:
14032:
14029:
14028:Valproic acid
14026:
14024:
14021:
14019:
14016:
14014:
14011:
14009:
14006:
14004:
14001:
13999:
13996:
13994:
13991:
13989:
13988:Phenobarbital
13986:
13984:
13981:
13979:
13976:
13974:
13971:
13969:
13966:
13964:
13961:
13959:
13956:
13954:
13951:
13949:
13946:
13944:
13941:
13939:
13936:
13933:
13929:
13926:
13924:
13921:
13919:
13916:
13914:
13911:
13909:
13906:
13904:
13901:
13899:
13896:
13894:
13891:
13889:
13888:Carbamazepine
13886:
13884:
13881:
13879:
13876:
13874:
13871:
13869:
13866:
13863:
13862:
13860:
13855:
13849:
13845:
13842:
13835:
13830:
13828:
13823:
13821:
13816:
13815:
13812:
13800:
13797:
13795:
13792:
13790:
13787:
13785:
13782:
13780:
13777:
13774:
13773:
13770:
13760:
13757:
13756:
13754:
13750:
13744:
13741:
13739:
13736:
13734:
13731:
13729:
13726:
13724:
13721:
13719:
13716:
13714:
13711:
13709:
13706:
13704:
13701:
13700:
13698:
13694:
13691:
13685:
13675:
13669:
13659:
13656:
13654:
13651:
13649:
13648:Valproic acid
13646:
13644:
13641:
13639:
13636:
13634:
13631:
13629:
13626:
13624:
13621:
13619:
13616:
13615:Nonsteroidal:
13613:
13612:
13609:
13606:
13604:
13601:
13599:
13596:
13594:
13591:
13589:
13586:
13584:
13581:
13579:
13576:
13574:
13571:
13569:
13566:
13564:
13561:
13558:
13557:
13555:
13551:
13545:
13544:Syringic acid
13542:
13540:
13537:
13535:
13532:
13530:
13527:
13525:
13522:
13520:
13517:
13516:Nonsteroidal:
13514:
13513:
13510:
13507:
13505:
13502:
13500:
13497:
13495:
13492:
13490:
13487:
13485:
13482:
13480:
13477:
13475:
13472:
13470:
13467:
13465:
13462:
13460:
13457:
13455:
13452:
13450:
13447:
13445:
13444:Guggulsterone
13442:
13440:
13437:
13435:
13432:
13430:
13427:
13425:
13422:
13420:
13417:
13414:
13413:
13411:
13405:
13396:
13390:
13387:
13385:
13382:
13379:
13378:
13375:
13372:
13370:
13367:
13365:
13362:
13360:
13357:
13355:
13352:
13350:
13349:Riligustilide
13347:
13345:
13342:
13340:
13337:
13335:
13332:
13331:Nonsteroidal:
13329:
13328:
13325:
13322:
13320:
13317:
13315:
13312:
13310:
13307:
13305:
13302:
13300:
13297:
13295:
13292:
13290:
13287:
13285:
13282:
13280:
13277:
13274:
13273:
13270:
13267:
13265:
13262:
13260:
13257:
13254:
13250:
13246:
13243:
13241:
13238:
13236:
13233:
13231:
13228:
13226:
13223:
13221:
13218:
13215:
13211:
13207:
13204:
13202:
13199:
13197:
13194:
13192:
13189:
13187:
13184:
13182:
13179:
13177:
13174:
13172:
13169:
13167:
13164:
13162:
13159:
13157:
13154:
13152:
13149:
13147:
13144:
13142:
13139:
13137:
13134:
13132:
13129:
13127:
13124:
13122:
13119:
13117:
13114:
13112:
13109:
13107:
13104:
13102:
13099:
13097:
13094:
13092:
13089:
13087:
13083:
13080:
13078:
13075:
13073:
13070:
13068:
13065:
13063:
13060:
13058:
13055:
13053:
13050:
13048:
13045:
13043:
13040:
13038:
13035:
13033:
13030:
13028:
13025:
13022:
13018:
13014:
13011:
13009:
13006:
13004:
13001:
12999:
12996:
12994:
12991:
12989:
12986:
12984:
12981:
12978:
12974:
12971:
12969:
12966:
12964:
12961:
12959:
12956:
12954:
12951:
12949:
12946:
12944:
12941:
12939:
12936:
12934:
12931:
12927:
12926:Ethandrostate
12924:
12923:
12922:
12919:
12917:
12914:
12912:
12909:
12907:
12904:
12902:
12899:
12897:
12894:
12892:
12889:
12887:
12886:Allylestrenol
12884:
12882:
12879:
12877:
12874:
12872:
12868:
12865:
12864:
12861:
12858:
12856:
12853:
12851:
12848:
12846:
12843:
12841:
12838:
12836:
12833:
12831:
12828:
12826:
12823:
12821:
12818:
12816:
12813:
12811:
12808:
12806:
12803:
12801:
12798:
12796:
12793:
12791:
12788:
12786:
12783:
12781:
12778:
12776:
12773:
12771:
12768:
12766:
12763:
12761:
12758:
12756:
12753:
12751:
12748:
12745:
12744:
12741:
12738:
12736:
12733:
12731:
12728:
12726:
12723:
12721:
12720:Pentagestrone
12718:
12716:
12713:
12711:
12708:
12706:
12703:
12701:
12698:
12696:
12693:
12691:
12688:
12686:
12683:
12681:
12678:
12676:
12673:
12671:
12668:
12666:
12663:
12661:
12658:
12656:
12653:
12651:
12648:
12646:
12643:
12641:
12638:
12636:
12633:
12631:
12628:
12626:
12623:
12621:
12618:
12616:
12613:
12611:
12608:
12606:
12605:Hydromadinone
12603:
12601:
12598:
12596:
12595:Gestobutanoyl
12593:
12591:
12588:
12586:
12583:
12581:
12578:
12576:
12573:
12571:
12568:
12566:
12563:
12561:
12558:
12556:
12553:
12551:
12548:
12546:
12543:
12541:
12538:
12536:
12533:
12531:
12528:
12526:
12523:
12521:
12518:
12516:
12513:
12511:
12508:
12506:
12503:
12501:
12498:
12496:
12493:
12491:
12488:
12486:
12483:
12481:
12478:
12476:
12475:Chlormadinone
12473:
12471:
12468:
12466:
12463:
12461:
12458:
12456:
12453:
12451:
12448:
12446:
12443:
12441:
12438:
12436:
12433:
12431:
12428:
12426:
12423:
12421:
12418:
12416:
12413:
12411:
12408:
12406:
12403:
12401:
12398:
12395:
12394:
12391:
12388:
12386:
12383:
12381:
12378:
12376:
12373:
12371:
12368:
12366:
12363:
12361:
12358:
12356:
12353:
12350:
12349:
12346:
12343:
12341:
12338:
12336:
12333:
12331:
12328:
12326:
12323:
12321:
12318:
12316:
12313:
12311:
12308:
12306:
12303:
12301:
12298:
12296:
12293:
12291:
12288:
12286:
12283:
12281:
12278:
12276:
12273:
12271:
12268:
12265:
12264:
12262:
12258:
12255:
12250:
12244:
12240:
12237:
12230:
12225:
12223:
12218:
12216:
12211:
12210:
12207:
12195:
12192:
12190:
12187:
12185:
12182:
12179:
12178:
12175:
12169:
12166:
12164:
12161:
12159:
12156:
12154:
12151:
12149:
12146:
12144:
12141:
12139:
12136:
12134:
12131:
12129:
12126:
12123:
12119:
12116:
12114:
12111:
12109:
12106:
12105:
12103:
12099:
12093:
12089:
12079:
12076:
12074:
12071:
12069:
12066:
12064:
12061:
12059:
12056:
12054:
12051:
12049:
12046:
12044:
12041:
12039:
12036:
12034:
12031:
12029:
12026:
12024:
12021:
12019:
12016:
12014:
12011:
12009:
12006:
12004:
12001:
11999:
11996:
11994:
11991:
11989:
11986:
11984:
11981:
11979:
11978:Phencyclidine
11976:
11974:
11971:
11969:
11966:
11964:
11961:
11959:
11956:
11954:
11951:
11949:
11948:Nitrous oxide
11946:
11944:
11941:
11939:
11936:
11934:
11931:
11929:
11926:
11924:
11921:
11919:
11916:
11914:
11911:
11909:
11906:
11904:
11901:
11899:
11896:
11894:
11891:
11889:
11888:Levomethadone
11886:
11884:
11881:
11879:
11876:
11874:
11871:
11869:
11866:
11864:
11861:
11859:
11856:
11854:
11851:
11849:
11846:
11844:
11841:
11839:
11836:
11834:
11833:Hexafluronium
11831:
11829:
11826:
11824:
11821:
11819:
11816:
11814:
11811:
11809:
11806:
11804:
11801:
11799:
11796:
11794:
11791:
11789:
11786:
11784:
11781:
11779:
11776:
11774:
11771:
11769:
11766:
11764:
11761:
11759:
11756:
11754:
11751:
11749:
11746:
11744:
11741:
11739:
11736:
11734:
11731:
11729:
11726:
11724:
11723:Decamethonium
11721:
11719:
11716:
11714:
11711:
11709:
11706:
11704:
11701:
11699:
11696:
11694:
11693:Cisatracurium
11691:
11689:
11686:
11684:
11681:
11679:
11676:
11674:
11671:
11669:
11666:
11663:
11659:
11655:
11654:Bungarotoxins
11652:
11650:
11647:
11644:
11640:
11639:pentobarbital
11636:
11633:
11631:
11628:
11626:
11623:
11621:
11618:
11616:
11613:
11611:
11608:
11606:
11603:
11601:
11598:
11595:
11591:
11587:
11583:
11582:α-Neurotoxins
11580:
11578:
11575:
11573:
11570:
11569:
11567:
11561:
11554:
11550:
11544:
11541:
11539:
11536:
11534:
11531:
11529:
11526:
11524:
11521:
11519:
11516:
11514:
11511:
11509:
11506:
11504:
11501:
11499:
11496:
11494:
11491:
11489:
11486:
11484:
11481:
11479:
11476:
11474:
11471:
11469:
11466:
11464:
11461:
11459:
11456:
11454:
11451:
11449:
11446:
11444:
11441:
11439:
11436:
11434:
11431:
11429:
11426:
11424:
11421:
11419:
11416:
11414:
11411:
11409:
11406:
11404:
11401:
11399:
11396:
11394:
11391:
11389:
11386:
11383:
11379:
11376:
11374:
11371:
11369:
11366:
11364:
11361:
11359:
11356:
11354:
11351:
11349:
11346:
11344:
11341:
11339:
11336:
11334:
11331:
11329:
11326:
11324:
11321:
11319:
11316:
11314:
11311:
11309:
11306:
11304:
11301:
11299:
11296:
11294:
11291:
11289:
11286:
11284:
11283:Decamethonium
11281:
11279:
11276:
11274:
11271:
11269:
11266:
11264:
11261:
11259:
11256:
11254:
11251:
11249:
11246:
11244:
11241:
11239:
11236:
11234:
11231:
11229:
11226:
11224:
11221:
11219:
11218:Acetylcholine
11216:
11214:
11211:
11209:
11206:
11204:
11201:
11199:
11196:
11194:
11191:
11189:
11186:
11184:
11181:
11179:
11176:
11174:
11171:
11169:
11166:
11165:
11163:
11157:
11150:
11146:
11143:
11138:
11132:
11128:
11125:
11118:
11113:
11111:
11106:
11104:
11099:
11098:
11095:
11083:
11082:
11078:
11076:
11075:
11067:
11065:
11064:
11060:
11058:
11057:
11053:
11050:
11049:
11046:
11036:
11033:
11031:
11028:
11026:
11023:
11021:
11018:
11016:
11013:
11011:
11008:
11006:
11003:
11002:
11000:
10995:
10989:
10983:
10980:
10978:
10975:
10973:
10970:
10968:
10965:
10963:
10960:
10958:
10955:
10953:
10950:
10948:
10945:
10943:
10940:
10938:
10935:
10933:
10930:
10928:
10925:
10923:
10920:
10918:
10915:
10913:
10910:
10908:
10905:
10903:
10900:
10898:
10895:
10893:
10890:
10889:
10887:
10882:
10876:
10873:
10869:
10863:
10859:
10848:
10844:
10843:
10841:
10836:
10830:
10824:
10821:
10819:
10816:
10813:
10809:
10805:
10801:
10797:
10794:
10792:
10789:
10787:
10784:
10781:
10777:
10773:
10770:
10767:
10763:
10759:
10755:
10751:
10747:
10746:levomethadone
10743:
10739:
10735:
10731:
10728:
10725:
10721:
10717:
10713:
10709:
10705:
10701:
10698:
10696:
10693:
10691:
10688:
10685:
10681:
10677:
10673:
10669:
10665:
10661:
10657:
10654:
10652:
10649:
10647:
10644:
10641:
10637:
10633:
10629:
10626:
10624:
10621:
10619:
10616:
10614:
10611:
10608:
10604:
10603:flunitrazepam
10600:
10596:
10592:
10588:
10585:
10583:
10580:
10577:
10576:
10573:
10570:
10568:
10565:
10563:
10560:
10558:
10555:
10553:
10550:
10547:
10543:
10539:
10535:
10531:
10527:
10523:
10520:
10518:
10515:
10513:
10510:
10508:
10505:
10503:
10500:
10498:
10495:
10493:
10490:
10488:
10485:
10483:
10482:Isostrychnine
10480:
10478:
10475:
10473:
10470:
10468:
10465:
10463:
10460:
10458:
10455:
10452:
10448:
10444:
10441:
10439:
10436:
10434:
10431:
10429:
10426:
10424:
10421:
10419:
10416:
10414:
10411:
10409:
10406:
10404:
10401:
10399:
10396:
10394:
10391:
10389:
10386:
10384:
10381:
10379:
10376:
10373:
10372:
10369:
10366:
10364:
10361:
10358:
10354:
10350:
10346:
10342:
10338:
10334:
10330:
10326:
10322:
10318:
10314:
10310:
10306:
10303:
10300:
10296:
10292:
10288:
10284:
10280:
10276:
10273:
10271:
10268:
10266:
10263:
10261:
10258:
10256:
10253:
10251:
10248:
10246:
10245:Nitrous oxide
10243:
10240:
10236:
10232:
10228:
10224:
10220:
10217:
10215:
10212:
10210:
10207:
10205:
10202:
10199:
10195:
10191:
10188:
10186:
10183:
10180:
10176:
10173:
10171:
10168:
10166:
10163:
10160:
10156:
10155:pentobarbital
10152:
10149:
10147:
10144:
10142:
10139:
10136:
10132:
10128:
10124:
10122:
10117:
10113:
10109:
10105:
10102:
10099:
10098:
10095:
10092:
10090:
10087:
10085:
10084:Quisqualamine
10082:
10080:
10077:
10075:
10072:
10070:
10067:
10065:
10062:
10060:
10054:
10052:
10046:
10044:
10038:
10036:
10030:
10028:
10025:
10023:
10020:
10018:
10015:
10013:
10010:
10008:
10002:
10000:
9994:
9992:
9989:
9987:
9984:
9982:
9979:
9977:
9974:
9971:
9970:
9968:
9963:
9957:
9954:
9950:
9944:
9940:
9936:
9933:
9926:
9921:
9919:
9914:
9912:
9907:
9906:
9903:
9893:
9892:
9888:
9884:
9881:
9875:
9869:
9866:
9864:
9861:
9859:
9856:
9854:
9851:
9848:
9847:
9843:
9839:
9835:
9834:isovaleramide
9831:
9827:
9824:
9822:
9819:
9816:
9812:
9809:
9806:
9802:
9798:
9794:
9791:
9789:
9786:
9784:
9781:
9779:
9776:
9774:
9771:
9769:
9766:
9764:
9761:
9759:
9756:
9754:
9751:
9749:
9746:
9744:
9741:
9739:
9736:
9734:
9731:
9728:
9724:
9720:
9716:
9712:
9709:
9707:
9704:
9702:
9699:
9697:
9694:
9692:
9689:
9687:
9684:
9682:
9679:
9676:
9672:
9671:niflumic acid
9668:
9664:
9660:
9657:
9655:
9652:
9650:
9647:
9645:
9642:
9640:
9637:
9634:
9630:
9626:
9622:
9618:
9615:
9613:
9610:
9608:
9605:
9603:
9600:
9598:
9597:Clomethiazole
9595:
9593:
9592:Chlormezanone
9590:
9588:
9585:
9583:
9582:Carbamazepine
9580:
9577:
9573:
9569:
9565:
9562:
9559:
9555:
9552:
9550:
9547:
9545:
9542:
9540:
9537:
9535:
9532:
9531:
9529:
9525:
9519:
9516:
9514:
9511:
9509:
9506:
9504:
9501:
9499:
9496:
9494:
9491:
9489:
9486:
9484:
9481:
9479:
9476:
9474:
9471:
9469:
9466:
9464:
9461:
9459:
9458:Nitrous oxide
9456:
9454:
9451:
9449:
9446:
9444:
9441:
9439:
9436:
9434:
9431:
9429:
9426:
9424:
9421:
9419:
9416:
9414:
9411:
9409:
9406:
9404:
9401:
9399:
9396:
9394:
9391:
9389:
9388:Diethyl ether
9386:
9384:
9381:
9379:
9376:
9374:
9371:
9369:
9366:
9364:
9361:
9359:
9356:
9354:
9351:
9349:
9346:
9344:
9341:
9339:
9336:
9334:
9331:
9329:
9326:
9324:
9321:
9319:
9316:
9314:
9311:
9309:
9306:
9305:
9303:
9301:
9297:
9293:
9287:
9284:
9282:
9279:
9277:
9274:
9272:
9269:
9267:
9264:
9262:
9259:
9257:
9254:
9252:
9249:
9247:
9244:
9242:
9239:
9238:
9236:
9234:
9230:
9224:
9221:
9219:
9216:
9214:
9211:
9209:
9206:
9205:
9203:
9201:
9197:
9191:
9190:Pyrithyldione
9188:
9186:
9183:
9181:
9178:
9176:
9173:
9172:
9170:
9168:
9164:
9158:
9155:
9153:
9150:
9148:
9145:
9144:
9142:
9140:
9136:
9130:
9127:
9125:
9122:
9120:
9117:
9115:
9112:
9110:
9107:
9105:
9102:
9100:
9097:
9095:
9092:
9090:
9087:
9085:
9082:
9080:
9077:
9075:
9072:
9070:
9067:
9065:
9062:
9060:
9057:
9055:
9052:
9050:
9047:
9045:
9042:
9040:
9037:
9035:
9032:
9030:
9027:
9025:
9022:
9020:
9017:
9015:
9012:
9010:
9007:
9005:
9002:
9000:
8997:
8995:
8992:
8990:
8987:
8985:
8981:
8978:
8977:
8974:
8971:
8969:
8966:
8964:
8961:
8959:
8956:
8954:
8951:
8949:
8946:
8944:
8941:
8939:
8935:
8934:
8930:
8929:
8926:
8923:
8921:
8918:
8916:
8913:
8911:
8908:
8906:
8902:
8901:
8897:
8896:
8893:
8890:
8888:
8885:
8883:
8880:
8878:
8875:
8873:
8870:
8868:
8864:
8863:
8859:
8858:
8856:
8854:
8850:
8844:
8841:
8839:
8836:
8834:
8831:
8829:
8826:
8824:
8821:
8819:
8816:
8814:
8811:
8809:
8806:
8804:
8801:
8799:
8796:
8794:
8791:
8789:
8786:
8784:
8781:
8779:
8776:
8774:
8771:
8769:
8766:
8764:
8761:
8759:
8756:
8754:
8751:
8749:
8746:
8744:
8741:
8739:
8736:
8734:
8731:
8729:
8726:
8724:
8721:
8719:
8715:
8713:
8710:
8708:
8705:
8703:
8700:
8698:
8695:
8693:
8690:
8688:
8685:
8683:
8680:
8679:
8677:
8675:
8671:
8665:
8662:
8660:
8657:
8655:
8652:
8650:
8647:
8645:
8642:
8640:
8637:
8636:
8634:
8632:
8628:
8622:
8619:
8617:
8614:
8612:
8609:
8607:
8604:
8602:
8599:
8597:
8594:
8592:
8589:
8587:
8584:
8582:
8579:
8577:
8574:
8572:
8569:
8567:
8564:
8562:
8559:
8557:
8554:
8552:
8549:
8548:
8546:
8543:
8539:
8533:
8530:
8528:
8525:
8523:
8520:
8519:
8517:
8515:
8511:
8505:
8502:
8499:
8495:
8492:
8490:
8487:
8485:
8482:
8480:
8477:
8475:
8472:
8470:
8467:
8465:
8462:
8460:
8457:
8455:
8452:
8450:
8447:
8445:
8442:
8440:
8437:
8435:
8432:
8431:
8429:
8427:
8423:
8417:
8414:
8412:
8409:
8407:
8404:
8402:
8399:
8397:
8396:Phenprobamate
8394:
8392:
8389:
8387:
8384:
8382:
8379:
8377:
8374:
8372:
8369:
8367:
8364:
8362:
8361:Hexapropymate
8359:
8357:
8354:
8352:
8349:
8347:
8344:
8342:
8339:
8337:
8336:Difebarbamate
8334:
8332:
8329:
8327:
8324:
8322:
8319:
8317:
8314:
8313:
8311:
8309:
8305:
8299:
8296:
8294:
8291:
8289:
8286:
8284:
8281:
8279:
8276:
8274:
8271:
8269:
8266:
8264:
8261:
8259:
8256:
8254:
8251:
8249:
8246:
8244:
8241:
8239:
8236:
8234:
8231:
8229:
8226:
8224:
8221:
8219:
8216:
8214:
8211:
8209:
8206:
8204:
8201:
8199:
8196:
8194:
8191:
8189:
8186:
8184:
8181:
8179:
8176:
8174:
8171:
8169:
8166:
8164:
8161:
8159:
8156:
8154:
8151:
8149:
8148:Nortetrazepam
8146:
8144:
8141:
8139:
8136:
8134:
8131:
8129:
8126:
8124:
8121:
8119:
8116:
8114:
8111:
8109:
8106:
8104:
8101:
8099:
8096:
8094:
8091:
8089:
8086:
8084:
8081:
8079:
8076:
8074:
8071:
8069:
8066:
8064:
8061:
8059:
8056:
8054:
8051:
8049:
8046:
8044:
8041:
8039:
8036:
8034:
8031:
8029:
8026:
8024:
8021:
8019:
8016:
8014:
8011:
8009:
8008:Flutoprazepam
8006:
8004:
8001:
7999:
7996:
7994:
7991:
7989:
7988:Flunitrazolam
7986:
7984:
7983:Flunitrazepam
7981:
7979:
7976:
7974:
7973:Flubromazolam
7971:
7969:
7968:Flubromazepam
7966:
7964:
7961:
7959:
7956:
7954:
7951:
7949:
7946:
7944:
7941:
7939:
7936:
7934:
7931:
7929:
7926:
7924:
7921:
7919:
7916:
7914:
7911:
7909:
7906:
7904:
7901:
7899:
7896:
7894:
7891:
7889:
7886:
7884:
7881:
7879:
7876:
7874:
7871:
7869:
7868:Cloniprazepam
7866:
7864:
7861:
7859:
7856:
7854:
7851:
7849:
7846:
7844:
7841:
7839:
7836:
7834:
7831:
7829:
7826:
7824:
7821:
7819:
7816:
7814:
7811:
7809:
7806:
7804:
7801:
7799:
7796:
7794:
7791:
7789:
7786:
7784:
7781:
7779:
7776:
7774:
7771:
7769:
7766:
7764:
7761:
7759:
7758:2-Oxoquazepam
7756:
7755:
7753:
7751:
7747:
7741:
7738:
7736:
7733:
7731:
7728:
7726:
7723:
7721:
7718:
7716:
7713:
7711:
7708:
7706:
7703:
7701:
7700:Thialbarbital
7698:
7696:
7695:Tetrabarbital
7693:
7691:
7688:
7686:
7683:
7681:
7680:Spirobarbital
7678:
7676:
7673:
7671:
7668:
7666:
7663:
7661:
7660:Proxibarbital
7658:
7656:
7653:
7651:
7650:Propallylonal
7648:
7646:
7643:
7641:
7638:
7636:
7633:
7631:
7630:Phenobarbital
7628:
7626:
7623:
7621:
7620:Pentobarbital
7618:
7616:
7613:
7611:
7610:Narcobarbital
7608:
7606:
7603:
7601:
7598:
7596:
7593:
7591:
7588:
7586:
7583:
7581:
7578:
7576:
7575:Heptobarbital
7573:
7571:
7568:
7566:
7563:
7561:
7558:
7556:
7553:
7551:
7548:
7546:
7545:Difebarbamate
7543:
7541:
7538:
7536:
7535:Cyclobarbital
7533:
7531:
7528:
7526:
7523:
7521:
7518:
7516:
7513:
7511:
7508:
7506:
7503:
7501:
7498:
7496:
7493:
7491:
7488:
7486:
7483:
7481:
7480:Benzobarbital
7478:
7476:
7473:
7471:
7468:
7466:
7463:
7461:
7458:
7456:
7453:
7451:
7448:
7446:
7443:
7442:
7440:
7438:
7434:
7428:
7425:
7423:
7420:
7418:
7415:
7413:
7410:
7408:
7406:
7402:
7400:
7398:
7394:
7392:
7389:
7387:
7384:
7382:
7379:
7377:
7374:
7372:
7369:
7367:
7364:
7362:
7359:
7357:
7354:
7352:
7351:Ethchlorvynol
7349:
7346:
7342:
7339:
7337:
7334:
7332:
7329:
7327:
7324:
7322:
7319:
7318:
7316:
7314:
7310:
7306:
7293:
7288:
7286:
7281:
7279:
7274:
7273:
7270:
7264:
7260:
7255:
7239:
7237:
7234:
7233:
7231:
7228:
7225:
7222:
7220:
7217:
7216:
7212:
7202:
7199:
7197:
7194:
7192:
7185:
7183:
7181:
7177:
7174:
7170:
7166:
7165:neurosteroids
7163:
7160:
7158:
7151:
7150:
7147:
7143:Miscellaneous
7140:
7136:
7121:
7120:levothyroxine
7113:
7109:
7106:
7103:
7099:
7095:
7092:
7090:
7087:
7084:
7080:
7076:
7072:
7068:
7067:brexpiprazole
7064:
7060:
7057:
7056:
7053:
7049:
7044:
7040:
7026:
7023:
7022:Irreversible:
7020:
7019:
7017:
7011:
7002:
6996:
6993:
6991:
6988:
6986:
6983:
6981:
6978:
6976:
6973:
6971:
6968:
6966:
6963:
6960:
6959:
6957:
6951:
6942:
6936:
6933:
6930:
6929:
6926:
6923:
6920:
6919:
6916:
6913:
6911:
6908:
6906:
6903:
6901:
6898:
6896:
6893:
6891:
6888:
6886:
6883:
6881:
6878:
6876:
6873:
6871:
6868:
6866:
6863:
6861:
6858:
6856:
6855:Isocarboxazid
6853:
6851:
6848:
6846:
6843:
6841:
6838:
6837:Irreversible:
6835:
6834:
6832:
6830:Non-selective
6828:
6824:
6820:
6815:
6811:
6797:
6794:
6793:
6791:
6787:
6781:
6778:
6776:
6773:
6771:
6768:
6766:
6763:
6762:
6760:
6755:
6749:
6743:
6740:
6738:
6735:
6733:
6730:
6728:
6727:Protriptyline
6725:
6723:
6720:
6718:
6715:
6713:
6710:
6708:
6705:
6703:
6702:Nortriptyline
6700:
6698:
6697:Nitroxazepine
6695:
6693:
6690:
6688:
6685:
6683:
6680:
6678:
6675:
6673:
6670:
6668:
6665:
6663:
6660:
6658:
6655:
6653:
6650:
6648:
6645:
6643:
6640:
6638:
6637:Demexiptiline
6635:
6633:
6630:
6628:
6625:
6623:
6620:
6618:
6615:
6613:
6612:Amitriptyline
6610:
6608:
6605:
6604:
6602:
6597:
6591:
6587:
6583:
6579:
6574:
6570:
6556:
6553:
6551:
6548:
6546:
6543:
6541:
6538:
6536:
6533:
6531:
6528:
6526:
6523:
6521:
6518:
6516:
6513:
6511:
6508:
6506:
6503:
6501:
6498:
6496:
6493:
6491:
6488:
6486:
6483:
6481:
6478:
6477:
6475:
6471:
6465:
6462:
6460:
6457:
6456:
6454:
6449:
6443:
6437:
6434:
6432:
6429:
6427:
6424:
6423:
6421:
6416:
6410:
6404:
6401:
6399:
6396:
6394:
6391:
6390:
6388:
6383:
6377:
6371:
6368:
6366:
6363:
6361:
6358:
6357:
6355:
6350:
6344:
6338:
6335:
6333:
6330:
6328:
6325:
6324:
6322:
6317:
6311:
6305:
6302:
6300:
6297:
6295:
6292:
6290:
6287:
6285:
6282:
6280:
6277:
6276:
6274:
6269:
6263:
6257:
6254:
6252:
6249:
6247:
6244:
6242:
6239:
6237:
6234:
6232:
6229:
6227:
6224:
6222:
6219:
6218:
6216:
6211:
6205:
6201:
6197:
6193:
6187:
6183:
6178:
6174:
6167:
6162:
6160:
6155:
6153:
6148:
6147:
6144:
6132:
6129:
6127:
6124:
6122:
6119:
6117:
6114:
6111:
6110:
6107:
6104:
6102:
6099:
6097:
6094:
6092:
6089:
6087:
6083:
6082:
6080:
6076:
6070:
6067:
6065:
6062:
6060:
6057:
6055:
6052:
6050:
6047:
6045:
6042:
6040:
6037:
6035:
6031:
6030:
6027:
6024:
6022:
6019:
6017:
6014:
6012:
6009:
6007:
6004:
6002:
5999:
5997:
5994:
5992:
5989:
5987:
5984:
5982:
5979:
5977:
5974:
5971:
5970:
5967:
5964:
5962:
5959:
5957:
5954:
5952:
5949:
5947:
5944:
5942:
5939:
5937:
5934:
5932:
5929:
5927:
5924:
5922:
5919:
5917:
5914:
5912:
5909:
5907:
5904:
5902:
5899:
5897:
5894:
5892:
5889:
5887:
5884:
5882:
5879:
5876:
5875:
5872:
5869:
5867:
5865:
5860:
5857:
5856:
5854:
5852:
5851:Neurosteroids
5848:
5838:
5837:Pregnanetriol
5835:
5833:
5830:
5828:
5825:
5823:
5820:
5817:
5816:
5813:
5810:
5808:
5805:
5803:
5800:
5798:
5795:
5793:
5790:
5788:
5785:
5783:
5780:
5778:
5775:
5774:
5772:
5770:
5766:
5759:
5755:
5751:
5748:
5746:
5743:
5741:
5738:
5736:
5733:
5731:
5728:
5726:
5723:
5721:
5718:
5716:
5713:
5711:
5708:
5706:
5703:
5701:
5698:
5696:
5693:
5691:
5688:
5686:
5683:
5681:
5678:
5675:
5674:
5671:
5668:
5666:
5663:
5661:
5658:
5656:
5653:
5651:
5648:
5646:
5643:
5641:
5638:
5636:
5633:
5631:
5628:
5626:
5623:
5620:
5619:
5616:
5613:
5611:
5608:
5606:
5603:
5601:
5598:
5596:
5593:
5591:
5588:
5586:
5583:
5581:
5578:
5576:
5573:
5571:
5568:
5566:
5563:
5561:
5558:
5556:
5553:
5551:
5548:
5546:
5543:
5541:
5540:17α-Estradiol
5538:
5536:
5533:
5531:
5528:
5526:
5523:
5521:
5518:
5515:
5514:
5512:
5510:
5506:
5500:
5497:
5495:
5492:
5490:
5487:
5485:
5482:
5480:
5477:
5475:
5472:
5470:
5467:
5465:
5462:
5460:
5457:
5455:
5452:
5450:
5447:
5445:
5442:
5440:
5437:
5435:
5432:
5430:
5427:
5425:
5422:
5420:
5417:
5415:
5412:
5410:
5407:
5404:
5403:
5400:
5397:
5395:
5392:
5390:
5387:
5385:
5382:
5380:
5377:
5375:
5372:
5370:
5367:
5365:
5362:
5360:
5357:
5355:
5352:
5350:
5347:
5345:
5342:
5340:
5337:
5335:
5332:
5330:
5327:
5325:
5322:
5320:
5317:
5315:
5312:
5311:
5309:
5307:
5303:
5300:
5298:
5294:
5284:
5281:
5279:
5276:
5274:
5271:
5269:
5266:
5264:
5261:
5259:
5256:
5254:
5251:
5249:
5246:
5244:
5241:
5239:
5236:
5234:
5231:
5230:
5228:
5226:
5222:
5216:
5213:
5211:
5208:
5205:
5204:
5201:
5198:
5196:
5193:
5191:
5188:
5186:
5183:
5181:
5178:
5176:
5173:
5171:
5168:
5166:
5163:
5161:
5158:
5156:
5153:
5151:
5148:
5146:
5143:
5141:
5138:
5136:
5133:
5132:
5130:
5128:
5124:
5121:
5119:
5115:
5109:
5106:
5104:
5101:
5099:
5096:
5094:
5091:
5089:
5086:
5084:
5081:
5079:
5077:
5072:
5070:
5068:
5063:
5061:
5058:
5057:
5055:
5053:
5049:
5045:
5042:
5035:
5030:
5028:
5023:
5021:
5016:
5015:
5012:
5000:
4997:
4995:
4992:
4990:
4987:
4985:
4982:
4980:
4977:
4975:
4972:
4970:
4967:
4965:
4962:
4960:
4957:
4955:
4952:
4951:
4949:
4945:
4941:
4934:
4929:
4927:
4922:
4920:
4915:
4914:
4911:
4905:
4901:
4900:
4895:
4893:
4889:
4888:
4883:
4881:
4877:
4876:
4871:
4870:
4859:
4855:
4850:
4845:
4841:
4837:
4833:
4829:
4825:
4820:
4816:
4812:
4808:
4804:
4799:
4794:
4790:
4786:
4781:
4780:
4766:
4762:
4758:
4754:
4750:
4746:
4742:
4738:
4731:
4723:
4719:
4714:
4709:
4705:
4701:
4697:
4693:
4689:
4682:
4674:
4670:
4665:
4660:
4656:
4652:
4648:
4644:
4640:
4633:
4625:
4621:
4617:
4613:
4609:
4605:
4598:
4590:
4586:
4582:
4578:
4574:
4570:
4566:
4562:
4555:
4547:
4541:
4537:
4536:
4528:
4520:
4516:
4512:
4508:
4504:
4500:
4492:
4490:
4481:
4477:
4472:
4467:
4463:
4459:
4455:
4451:
4447:
4440:
4432:
4426:
4418:
4412:
4396:
4392:
4386:
4370:
4366:
4364:
4358:
4352:
4344:
4340:
4335:
4330:
4325:
4320:
4316:
4312:
4308:
4304:
4300:
4293:
4285:
4281:
4277:
4273:
4269:
4262:
4254:
4250:
4246:
4242:
4235:
4227:
4223:
4218:
4213:
4209:
4205:
4201:
4197:
4193:
4186:
4184:
4182:
4180:
4178:
4169:
4165:
4161:
4157:
4153:
4149:
4145:
4141:
4134:
4126:
4122:
4118:
4114:
4110:
4106:
4102:
4098:
4091:
4089:
4080:
4076:
4072:
4068:
4064:
4060:
4056:
4052:
4045:
4043:
4034:
4030:
4026:
4022:
4018:
4014:
4010:
4006:
3998:
3996:
3987:
3983:
3979:
3975:
3971:
3967:
3963:
3959:
3952:
3950:
3941:
3937:
3932:
3927:
3923:
3919:
3915:
3911:
3907:
3900:
3898:
3896:
3887:
3883:
3878:
3873:
3869:
3865:
3861:
3854:
3846:
3842:
3838:
3834:
3830:
3826:
3822:
3818:
3810:
3802:
3798:
3793:
3788:
3784:
3780:
3776:
3772:
3771:Endocrinology
3768:
3761:
3753:
3749:
3744:
3739:
3735:
3731:
3727:
3723:
3722:Endocrinology
3719:
3712:
3704:
3700:
3695:
3690:
3686:
3682:
3678:
3674:
3670:
3663:
3661:
3652:
3648:
3643:
3638:
3634:
3630:
3626:
3622:
3618:
3611:
3603:
3599:
3595:
3591:
3587:
3583:
3579:
3575:
3568:
3560:
3556:
3551:
3546:
3542:
3538:
3534:
3530:
3526:
3519:
3517:
3515:
3506:
3502:
3497:
3492:
3488:
3484:
3480:
3473:
3465:
3461:
3457:
3453:
3449:
3445:
3441:
3437:
3430:
3422:
3418:
3414:
3410:
3405:
3400:
3396:
3392:
3388:
3384:
3380:
3373:
3365:
3361:
3357:
3353:
3346:
3338:
3334:
3329:
3324:
3320:
3316:
3312:
3308:
3304:
3289:
3281:
3277:
3273:
3269:
3265:
3261:
3257:
3253:
3246:
3238:
3234:
3230:
3226:
3219:
3211:
3207:
3203:
3201:9780199746545
3197:
3193:
3189:
3185:
3178:
3170:
3166:
3161:
3156:
3152:
3148:
3144:
3137:
3130:
3126:
3122:
3118:
3114:
3109:
3104:
3100:
3096:
3092:
3085:
3077:
3073:
3069:
3065:
3061:
3057:
3053:
3049:
3042:
3034:
3030:
3026:
3022:
3018:
3014:
3010:
3006:
2999:
2991:
2987:
2982:
2977:
2973:
2969:
2965:
2961:
2957:
2950:
2942:
2938:
2934:
2930:
2925:
2920:
2916:
2912:
2908:
2904:
2900:
2893:
2891:
2882:
2878:
2874:
2870:
2866:
2862:
2858:
2854:
2847:
2839:
2835:
2831:
2827:
2823:
2819:
2812:
2804:
2800:
2795:
2790:
2785:
2780:
2776:
2772:
2768:
2764:
2760:
2753:
2745:
2741:
2736:
2731:
2727:
2723:
2719:
2715:
2711:
2704:
2702:
2693:
2689:
2685:
2681:
2677:
2673:
2669:
2665:
2657:
2649:
2645:
2640:
2635:
2630:
2625:
2622:: 3017–3026.
2621:
2617:
2613:
2606:
2604:
2595:
2591:
2586:
2581:
2576:
2571:
2567:
2563:
2559:
2548:
2533:
2529:
2523:
2508:
2507:
2502:
2495:
2479:
2475:
2469:
2453:
2451:
2445:
2439:
2437:
2428:
2424:
2419:
2414:
2410:
2406:
2402:
2398:
2394:
2387:
2379:
2375:
2370:
2365:
2361:
2357:
2353:
2349:
2345:
2338:
2322:
2316:
2309:
2308:public domain
2290:
2286:
2284:
2278:
2272:
2270:
2268:
2266:
2264:
2262:
2260:
2258:
2256:
2254:
2252:
2243:
2239:
2234:
2229:
2225:
2223:9780444536303
2219:
2215:
2211:
2207:
2200:
2198:
2196:
2194:
2192:
2190:
2188:
2186:
2177:
2173:
2169:
2165:
2161:
2157:
2153:
2149:
2142:
2140:
2138:
2136:
2134:
2132:
2130:
2128:
2126:
2124:
2122:
2120:
2118:
2116:
2114:
2112:
2110:
2108:
2091:
2087:
2083:
2077:
2075:
2059:
2055:
2051:
2045:
2029:
2028:
2023:
2017:
2015:
2013:
2011:
2009:
2007:
2005:
2003:
2001:
1999:
1997:
1995:
1993:
1991:
1989:
1987:
1985:
1983:
1981:
1979:
1977:
1975:
1973:
1971:
1969:
1967:
1965:
1956:
1952:
1948:
1944:
1940:
1936:
1932:
1928:
1921:
1919:
1910:
1906:
1902:
1898:
1894:
1890:
1886:
1882:
1875:
1873:
1864:
1860:
1856:
1852:
1848:
1844:
1837:
1835:
1826:
1822:
1817:
1812:
1808:
1804:
1800:
1796:
1792:
1788:
1784:
1777:
1775:
1765:
1760:
1756:
1752:
1748:
1741:
1739:
1734:
1726:
1724:
1719:
1717:
1713:
1708:
1704:
1700:
1696:
1694:
1690:
1686:
1680:
1678:
1674:
1670:
1660:
1658:
1657:infusion bags
1654:
1650:
1649:sterile water
1646:
1642:
1638:
1634:
1630:
1626:
1622:
1618:
1614:
1611:
1601:
1599:
1596:
1586:
1583:
1581:
1577:
1562:
1560:
1556:
1551:
1547:
1545:
1535:
1533:
1529:
1525:
1520:
1518:
1514:
1510:
1506:
1502:
1498:
1494:
1490:
1486:
1482:
1479:
1476:A variety of
1469:
1467:
1463:
1460:
1456:
1452:
1448:
1438:
1436:
1432:
1428:
1424:
1420:
1416:
1412:
1411:pregnanedione
1408:
1404:
1398:
1388:
1386:
1382:
1378:
1374:
1371:
1367:
1363:
1359:
1355:
1351:
1347:
1343:
1339:
1335:
1332:mediated via
1331:
1327:
1323:
1319:
1315:
1311:
1307:
1304:
1289:
1287:
1283:
1259:
1255:
1237:
1235:
1227:
1219:
1215:
1201:
1199:
1195:
1187:
1180:
1172:
1168:
1159:
1157:
1153:
1145:
1141:
1137:
1133:
1129:
1125:
1121:
1120:progestogenic
1117:
1113:
1109:
1106:
1101:
1099:
1095:
1091:
1087:
1083:
1079:
1071:
1067:
1063:
1055:
1042:
1032:
1024:
1016:
1012:
1008:
1004:
1001:
998:
995:
980:
978:
974:
970:
966:
962:
958:
953:
951:
947:
943:
939:
935:
930:
928:
924:
920:
916:
912:
908:
904:
900:
896:
892:
888:
884:
880:
876:
872:
868:
864:
860:
856:
846:
844:
840:
836:
832:
828:
824:
820:
810:
808:
798:
796:
786:
784:
780:
775:
773:
770:
767:
763:
759:
751:
747:
743:
739:
735:
731:
727:
723:
719:
717:
713:
709:
705:
701:
698:
694:
691:
687:
673:
668:
667:
664:
657:
648:
647:
644:
637:
630:
626:
625:
623:
620:
615:
608:
606:
602:
581:
579:
575:
570:
562:
558:
554:
553:
551:
542:
538:
531:
527:
526:
524:
522:
518:
511:
507:
506:
504:
502:
498:
491:
487:
486:
484:
482:
478:
471:
467:
466:
464:
462:
458:
451:
447:
446:
444:
442:
438:
431:
427:
426:
424:
422:
418:
411:
407:
406:
404:
397:
393:
386:
382:
381:
379:
377:
373:
364:
363:
360:
353:
348:
344:
339:
336:
334:
330:
326:
324:
317:
313:
309:
305:
301:
297:
293:
289:
285:
281:
279:
275:
271:
269:
265:
261:
258:
256:
252:
248:
244:
237:
225:
224:
222:
220:
216:
211:
203:
198:
195:
194:
192:
190:
186:
183:
179:
178:Neurosteroids
176:
174:
170:
167:
164:
162:
156:
149:
145:
135:
132:
127:
118:
117:
115:
113:
109:
105:
101:
99:
95:
91:
87:
85:
81:
77:
68:
64:
60:
56:
54:
50:
47:Clinical data
45:
41:
36:
32:
27:
19:
14924:Progestogens
14919:5α-Pregnanes
14817:
14797:Ketoconazole
14794:Antagonists:
14793:
14767:Troglitazone
14742:Tetracycline
14697:Spiroxatrine
14642:Quingestrone
14637:Progesterone
14622:Pregnenolone
14617:Pregnanolone
14607:Pregnanediol
14602:Prednisolone
14527:Mifepristone
14454:
14429:Griseofulvin
14409:Fenbendazole
14394:Famprofazone
14389:Erythromycin
14384:Epothilone B
14369:Eburnamonine
14264:Clotrimazole
14254:Clofenvinfos
14189:Antimycotics
14163:
14120:
14083:Okadaic acid
14035:Antagonists:
14034:
14023:Troglitazone
13958:Mifepristone
13953:Methoxychlor
13948:Griseofulvin
13943:Ellagic acid
13923:Cypermethrin
13913:Clotrimazole
13864:
13759:Mifepristone
13743:Progesterone
13738:Pregnenolone
13733:Mifepristone
13727:
13618:Darolutamide
13614:
13603:Toripristone
13598:RTI 3021–022
13568:Lilopristone
13563:Aglepristone
13559:
13515:
13494:Telapristone
13415:
13380:
13330:
13289:Drospirenone
13275:
13062:Quingestanol
13037:Norgestimate
13032:Norgesterone
13027:Noretynodrel
12943:Etonogestrel
12869:Progestins:
12866:
12860:Trimegestone
12845:Promegestone
12746:
12735:Proligestone
12675:Melengestrol
12640:Medrogestone
12575:Flumedroxone
12530:Cymegesolate
12520:Clomegestone
12396:
12351:
12345:Quingestrone
12335:Progesterone
12266:
12063:Tubocurarine
11993:Promegestone
11988:Progesterone
11903:Mecamylamine
11713:Cyclopropane
11703:Coronaridine
11635:Barbiturates
11620:Anatruxonium
11609:
11590:α-cobratoxin
11433:Sazetidine A
11353:JNJ-39393406
11343:Ispronicline
11079:
11068:
11061:
11054:
10780:picrotoxinin
10724:progesterone
10716:DHEA sulfate
10684:ginkgolide M
10680:ginkgolide J
10676:ginkgolide C
10672:ginkgolide B
10668:ginkgolide A
10640:nitrendipine
10578:
10375:Antagonists:
10374:
10250:Penicillin G
10194:ginsenosides
10151:Barbiturates
10120:
10100:
9981:β-ABA (BABA)
9972:
9879:
9878:
9849:
9706:Lavender oil
9448:Nitric oxide
9368:Cryofluorane
9313:Acetophenone
9271:Methaqualone
9266:Mecloqualone
9261:Mebroqualone
9251:Diproqualone
9246:Cloroqualone
9175:Glutethimide
8979:
8931:
8898:
8860:
8833:Testosterone
8798:Progesterone
8763:Hydroxydione
8712:Androsterone
8686:
8639:Acecarbromal
8544:constituents
8331:Cyclarbamate
8321:Carisoprodol
8093:Metaclazepam
8088:Menitrazepam
8078:Meclonazepam
8073:Lormetazepam
8003:Flutemazepam
7828:Ciclotizolam
7818:Carburazepam
7710:Thiobarbital
7670:Secobarbital
7635:Phetharbital
7615:Nealbarbital
7600:Methohexital
7585:Hexobarbital
7520:Butallylonal
7515:Butobarbital
7470:Barbexaclone
7465:Aprobarbital
7450:Allobarbital
7437:Barbiturates
7404:
7396:
7386:Petrichloral
7187:Oxitriptan (
7179:
7168:
7063:aripiprazole
7021:
6970:Metralindole
6961:
6931:
6921:
6900:Pivhydrazine
6890:Pheniprazine
6836:
6742:Trimipramine
6732:Quinupramine
6632:Clomipramine
6627:Butriptyline
6550:Teniloxazine
6545:Tandospirone
6530:Metryptamine
6525:Medifoxamine
6510:Indeloxazine
6464:Vortioxetine
6226:Escitalopram
6112:
6084:
6064:Androsterone
6059:Androstenone
6032:
6021:DHEA sulfate
6011:Androsterone
5973:Androstanes:
5972:
5956:Progesterone
5946:Pregnenolone
5941:Pregnanolone
5905:
5877:
5863:
5859:Cholestanes:
5858:
5827:Pregnanediol
5819:Metabolites:
5818:
5777:Progesterone
5769:Progestogens
5677:Metabolites:
5676:
5655:DHEA sulfate
5621:
5516:
5406:Metabolites:
5405:
5399:Testosterone
5364:DHEA sulfate
5349:Androsterone
5297:Sex steroids
5207:Metabolites:
5206:
5200:Progesterone
5195:Pregnenolone
5083:Pregnenolone
5075:
5066:
4999:Pregnanolone
4993:
4989:Neurosteroid
4940:Progesterone
4897:
4885:
4873:
4831:
4827:
4791:(1): 20–34.
4788:
4784:
4740:
4736:
4730:
4695:
4691:
4681:
4646:
4642:
4632:
4607:
4603:
4597:
4564:
4560:
4554:
4534:
4527:
4502:
4498:
4453:
4449:
4439:
4425:
4411:
4399:. Retrieved
4395:the original
4385:
4373:. Retrieved
4360:
4351:
4306:
4302:
4292:
4275:
4271:
4261:
4244:
4240:
4234:
4199:
4195:
4143:
4139:
4133:
4100:
4096:
4054:
4050:
4008:
4005:Neuroscience
4004:
3961:
3957:
3913:
3909:
3867:
3863:
3853:
3820:
3816:
3809:
3774:
3770:
3760:
3725:
3721:
3711:
3676:
3672:
3624:
3620:
3610:
3577:
3573:
3567:
3532:
3528:
3486:
3482:
3472:
3439:
3435:
3429:
3386:
3382:
3372:
3355:
3351:
3345:
3313:(1): 88–99.
3310:
3306:
3288:
3255:
3251:
3245:
3228:
3224:
3218:
3186:: 984–1002.
3183:
3177:
3150:
3146:
3136:
3128:
3098:
3094:
3084:
3051:
3047:
3041:
3008:
3004:
2998:
2966:(1): 12–24.
2963:
2959:
2949:
2909:(1): 42–53.
2906:
2902:
2856:
2852:
2846:
2821:
2817:
2811:
2766:
2762:
2752:
2717:
2713:
2667:
2663:
2656:
2619:
2615:
2565:
2561:
2547:
2537:30 September
2535:. Retrieved
2531:
2522:
2510:. Retrieved
2504:
2494:
2484:15 September
2482:. Retrieved
2477:
2468:
2456:. Retrieved
2447:
2400:
2396:
2386:
2351:
2347:
2337:
2325:. Retrieved
2323:. NIH Toxnet
2315:
2293:. Retrieved
2280:
2205:
2151:
2147:
2094:. Retrieved
2085:
2061:. Retrieved
2053:
2044:
2032:. Retrieved
2025:
1930:
1926:
1884:
1880:
1846:
1842:
1790:
1786:
1754:
1750:
1720:
1712:pregnenolone
1697:
1681:
1666:
1643:and must be
1607:
1592:
1589:Legal status
1584:
1573:
1552:
1548:
1541:
1521:
1501:hydroxydione
1475:
1455:intermediate
1447:5α-reductase
1444:
1441:Biosynthesis
1427:pregnanolone
1423:pregnanolone
1419:pregnanediol
1400:
1300:
1292:Pharmacology
1243:
1226:luteal phase
1214:irritability
1211:
1160:
1102:
1043:
1011:pregnenolone
1003:neurosteroid
991:
977:virilization
965:progesterone
954:
938:pregnanolone
931:
881:, sedative,
852:
816:
813:Side effects
807:HAM-D scores
804:
792:
789:Medical uses
776:
760:, the major
746:neurosteroid
722:Side effects
720:
707:
703:
700:progesterone
693:neurosteroid
685:
684:
530:ChEMBL207538
320:Elimination
219:Legal status
213:Legal status
112:License data
18:
14782:Zafirlukast
14752:Thiothixene
14732:Terconazole
14682:Simvastatin
14557:Nisoldipine
14552:Nilvadipine
14537:Nicardipine
14507:Metacycline
14334:Dimercaprol
14289:Demecolcine
14249:Clindamycin
14244:Ciglitazone
14194:Artemisinin
14174:Ambrisentan
14078:Nigramide J
14013:Telmisartan
13973:Nicardipine
13883:Benfuracarb
13878:Artemisinin
13752:Antagonists
13578:Onapristone
13553:Antagonists
13324:Spirorenone
13294:Mespirenone
12983:Lynestrenol
12933:Ethisterone
12911:Desogestrel
12891:Altrenogest
12850:Segesterone
12825:Norgestomet
12815:Nomegestrol
12790:Gestadienol
12775:Demegestone
12730:Pentarane A
12550:Edogestrone
12540:Delmadinone
12500:Cismadinone
12390:Trengestone
12320:Dimepregnen
12168:Pirisudanol
12133:Cyprodenate
12113:Adafenoxate
12028:Surugatoxin
12018:Sevoflurane
11973:Pentolinium
11953:Norketamine
11873:Laudanosine
11803:Erythravine
11793:Encenicline
11778:Dipyrandium
11748:Dextrorphan
11594:α-conotoxin
11553:Antagonists
11538:WAY-317,538
11533:Varenicline
11523:Tropisetron
11513:Tebanicline
11458:SSR-180,711
11423:Rivanicline
11413:Pozanicline
11408:PNU-282,987
11403:PNU-120,596
11398:PHA-709,829
11393:PHA-543,613
11333:Galantamine
11308:Epiboxidine
11303:Epibatidine
11223:Altinicline
10977:SSR-504,734
10972:SSR-103,800
10962:PF-03463275
10942:Mardepodect
10862:Transporter
10808:tropisetron
10750:levorphanol
10742:dextrorphan
10664:ginkgolides
10632:nicardipine
10487:Laudanosine
10408:Cacotheline
10398:Bicuculline
10345:sevoflurane
10295:tropisetron
10179:nicardipine
10022:Hypotaurine
9788:Stiripentol
9783:Seproxetine
9753:Niacinamide
9733:Loreclezole
9554:Avermectins
9518:Vinyl ether
9488:Sevoflurane
9468:Paraldehyde
9418:Halopropane
9241:Afloqualone
9223:Tracazolate
9218:ICI-190,622
9208:Cartazolate
9185:Piperidione
9180:Methyprylon
9147:Fospropofol
9069:Pipequaline
8877:Pazinaclone
8867:Eszopiclone
8723:Cholesterol
8707:Androstenol
8631:Monoureides
8611:Methysticin
8411:Tetrabamate
8391:Pentabamate
8381:Meprobamate
8351:Febarbamate
8316:Carisbamate
8268:Triflubazam
8258:Tolufazepam
8218:Rilmazafone
8213:Remimazolam
8188:Proflazepam
8173:Pivoxazepam
8133:Nitrazepate
8123:Nimetazepam
8058:Lopirazepam
8028:Haloxazolam
7978:Fludiazepam
7923:Doxefazepam
7898:Delorazepam
7878:Clotiazepam
7873:Clorazepate
7838:Cinolazepam
7735:Vinbarbital
7690:Tetrabamate
7645:Probarbital
7625:Phenallymal
7590:Metharbital
7565:Febarbamate
7460:Amobarbital
7361:Isopropanol
7331:Chloralodol
7226:from market
7169:brexanolone
7083:risperidone
6980:Moclobemide
6962:Reversible:
6922:Reversible:
6845:Iproclozide
6780:Setiptiline
6775:Mirtazapine
6765:Maprotiline
6722:Propizepine
6707:Noxiptiline
6692:Metapramine
6682:Lofepramine
6652:Dimetacrine
6642:Desipramine
6515:Flupentixol
6500:Etryptamine
6485:Amisulpride
6480:Agomelatine
6426:Etoperidone
6403:Setiptiline
6398:Mirtazapine
6370:Nomifensine
6327:Atomoxetine
6304:Venlafaxine
6294:Milnacipran
6236:Fluvoxamine
5986:7-Keto-DHEA
5871:Cholesterol
5660:7-Keto-DHEA
5273:Aldosterone
5060:Cholesterol
4899:NCT02942017
4887:NCT02614547
4875:NCT02942004
4401:3 September
4375:24 November
2327:26 December
2096:24 November
2034:23 November
1595:Schedule IV
1481:derivatives
1472:Derivatives
1459:hippocampus
1383:and 42% in
1362:metabolites
1322:metabolized
1062:-ρ receptor
1013:, and is a
738:hot flashes
704:brexanolone
612: g·mol
510:CHEBI:50169
350:Identifiers
238:Schedule IV
166:Intravenous
131:Brexanolone
98:MedlinePlus
62:Other names
53:Trade names
14863:Categories
14762:Tianeptine
14727:Tenylidone
14722:Tacrolimus
14667:Rimexolone
14657:Rifampicin
14597:Plicamycin
14582:Paclitaxel
14567:Omeprazole
14547:Nifedipine
14522:Mevastatin
14517:Metyrapone
14497:Lovastatin
14492:Loratadine
14449:Hyperforin
14439:Haloprogin
14404:Felodipine
14379:Enzacamene
14359:Dronabinol
14324:Diclazuril
14303:prasterone
14259:Chloroxine
14234:Cephradine
14204:Bile acids
14018:Tolnaftate
13983:Permethrin
13968:Nevirapine
13963:Nefazodone
13932:prasterone
13893:Carvedilol
13873:Amiodarone
13844:modulators
13608:Zanoterone
13573:Lonaprisan
13560:Steroidal:
13534:Naringenin
13524:Kaempferol
13504:Vilaprisan
13434:Asoprisnil
13416:Steroidal:
13389:ORG-201745
13369:Tanaproget
13264:Trestolone
13201:Nandrolone
13196:Mibolerone
13131:Dienedione
13121:Bolandione
13082:Tosagestin
13057:Oxendolone
13042:Norgestrel
12993:Metynodiol
12963:Gestrinone
12938:Ethynerone
12835:Oxogestone
12700:Mometasone
12590:Gestaclone
12555:Flugestone
12510:Clogestone
12450:Anagestone
12239:modulators
12128:Citicoline
12108:Acetyl-coA
12092:Precursors
12068:Vanoxerine
12058:Tropeinium
12043:Toxiferine
12008:Reboxetine
11998:Radafaxine
11943:Neramexane
11933:Mivacurium
11928:Metocurine
11893:Malouetine
11858:Isoflurane
11813:Fazadinium
11808:Esketamine
11788:Doxacurium
11773:Dioscorine
11733:Desflurane
11698:Coclaurine
11630:Atracurium
11615:Amantadine
11605:Alcuronium
11358:Levamisole
11348:Ivermectin
11293:Dianicline
11253:Butinoline
11238:Anatoxin-a
11127:modulators
10982:Tilapertin
10937:LY-2365109
10932:Iclepertin
10927:GSK1018921
10812:zatosetron
10800:bemesetron
10772:Picrotoxin
10690:Imipramine
10660:bilobalide
10646:Furosemide
10636:nifedipine
10607:flurazepam
10595:clonazepam
10591:bromazepam
10562:Strychnine
10557:Sinomenine
10522:Quinolines
10512:Pitrazepin
10433:Dendrobine
10418:Colchicine
10337:isoflurane
10321:desflurane
10317:chloroform
10299:zatosetron
10283:bemesetron
10235:minaxolone
10223:alfaxolone
10209:Ivermectin
10146:Anandamide
10069:Milacemide
10059:-Threonine
10027:Ivermectin
9935:modulators
9821:Topiramate
9811:Terpenoids
9768:Propanidid
9758:Org 25,435
9686:Flupirtine
9681:Fluoxetine
9587:Chloralose
9558:ivermectin
9463:Norflurane
9428:Isoflurane
9373:Desflurane
9363:Chloroform
9323:Aliflurane
9256:Etaqualone
9084:SB-205,384
9014:CP-615,003
9009:CL-218,872
8963:Panadiplon
8953:Lorediplon
8882:Suproclone
8843:Zuranolone
8803:Renanolone
8788:Posovolone
8768:Minaxolone
8758:Ganaxolone
8697:Alfaxalone
8692:Alfadolone
8682:Acebrochol
8649:Bromisoval
8527:Metomidate
8514:Imidazoles
8474:Hispidulin
8426:Flavonoids
8386:Nisobamate
8376:Mebutamate
8346:Ethinamate
8341:Emylcamate
8308:Carbamates
8278:Tuclazepam
8253:Tetrazepam
8208:Reclazepam
8183:Premazepam
8163:Phenazepam
8143:Nordazepam
8138:Nitrazolam
8128:Nitrazepam
8108:Motrazepam
8063:Loprazolam
8053:Lofendazam
8038:Imidazenil
7998:Flutazolam
7993:Flurazepam
7963:Fletazepam
7918:Dimdazenil
7913:Diclazepam
7893:Cyprazepam
7883:Cloxazolam
7863:Clonazolam
7858:Clonazepam
7848:Climazolam
7808:Brotizolam
7803:Bromazolam
7798:Bromazepam
7793:Bretazenil
7788:Bentazepam
7778:Arfendazam
7773:Alprazolam
7768:Adinazolam
7740:Vinylbital
7720:Thiopental
7595:Methitural
7510:Buthalital
7505:Butalbital
7356:Isobutanol
7201:Tryptophan
7173:zuranolone
7079:quetiapine
7075:olanzapine
7071:lurasidone
7025:Selegiline
7015:-selective
6995:Toloxatone
6990:Tetrindole
6985:Pirlindole
6965:Eprobemide
6955:-selective
6935:Bifemelane
6925:Caroxazone
6885:Phenelzine
6870:Mebanazine
6850:Iproniazid
6737:Tianeptine
6717:Pipofezine
6687:Melitracen
6667:Imipramine
6647:Dibenzepin
6607:Amineptine
6555:Tianeptine
6540:Pivagabine
6535:Oxaflozane
6495:Esketamine
6459:Vilazodone
6431:Nefazodone
6360:Amineptine
6337:Viloxazine
6332:Reboxetine
6284:Duloxetine
6256:Zimelidine
6251:Sertraline
6246:Paroxetine
6231:Fluoxetine
6221:Citalopram
6101:Calcitriol
6034:Pheromones
5878:Pregnanes:
5052:Precursors
5041:Endogenous
4834:: 100196.
4798:1607.02870
4202:: 100196.
2568:: 699740.
2063:22 October
1729:References
1641:hypertonic
1517:renanolone
1505:minaxolone
1497:ganaxolone
1493:alfaxolone
1489:alfadolone
1395:See also:
1338:conjugated
1258:alprazolam
1218:aggression
1122:effects. (
1054:δ subunits
1041:receptor.
997:inhibitory
994:endogenous
946:anesthesia
911:neurogenic
899:anesthetic
859:anxiolytic
831:alprazolam
766:inhibitory
744:. It is a
730:sleepiness
617:3D model (
605:Molar mass
470:S39XZ5QV8Y
441:ChemSpider
376:CAS Number
359:IUPAC name
278:Metabolism
173:Drug class
14914:Pregnanes
14687:Sirolimus
14677:Ritonavir
14672:Riodipine
14662:Rifaximin
14647:Reserpine
14632:Proadifen
14577:Oxatomide
14532:Nafcillin
14502:Meclizine
14364:Droxidopa
14344:Docetaxel
14269:Colforsin
14219:Bumecaine
14209:Bithionol
14121:Agonists:
14098:T-0901317
14073:Meclizine
14003:Reserpine
13993:Phenytoin
13978:Octicizer
13938:Efavirenz
13865:Agonists:
13658:ZM-172406
13653:ZM-150271
13643:LG-121046
13638:LG-120830
13633:LG-100128
13628:LG-100127
13623:LG-001447
13593:ORG-33628
13588:ORG-31806
13583:ORG-31710
13529:LG-120920
13509:ZK-137316
13489:RMI-12936
13484:ORG-33628
13479:ORG-31710
13454:LG-120838
13384:ORG-47241
13374:ZM-182345
13364:RWJ-60130
13359:RWJ-49853
13354:RWJ-26819
13344:LG-100128
13304:Prorenone
13284:Canrenone
13259:Trendione
13136:Dienolone
13111:Bolandiol
12958:Gestodene
12948:Etynodiol
12916:Dienogest
12901:Cingestol
12765:Amadinone
12710:Osaterone
12660:Megestrol
12435:Algestone
12385:Ro 6-3129
12325:Diosgenin
11968:Pentamine
11963:Pempidine
11913:Methadone
11908:Memantine
11828:Halothane
11818:Gallamine
11798:Enflurane
11753:Diadonium
11668:Bupropion
11453:SIB-1553A
11448:SIB-1508Y
11438:SB-206553
11263:Carbachol
11243:AR-R17779
11233:Anatabine
11228:Anabasine
11193:A-867,744
11188:A-582,941
11183:A-366,833
11030:ORG-25543
11010:Amoxapine
10967:Sarcosine
10947:ORG-24598
10912:CP-802079
10818:Verapamil
10804:LY-278584
10796:Tropeines
10762:pethidine
10758:oripavine
10651:Genistein
10582:Amiloride
10462:Gelsemine
10438:Diaboline
10423:Colubrine
10333:halothane
10329:enflurane
10305:Volatiles
10291:LY-278584
10275:Tropeines
10270:Triclofos
10260:Tamoxifen
10239:ORG-20599
10185:Etomidate
10108:brometone
10089:Sarcosine
10064:MDL-27531
9976:β-Alanine
9973:Agonists:
9880:See also:
9842:valerenol
9763:Phenytoin
9743:Monastrol
9701:Lanthanum
9696:KRM-II-81
9659:Fenamates
9654:Etifoxine
9649:Etazepine
9644:Efavirenz
9602:Darigabat
9498:Teflurane
9483:Roflurane
9478:Propylene
9423:Halothane
9408:Fluroxene
9393:Enflurane
9296:Volatiles
9213:Etazolate
9124:Viqualine
9079:RWJ-51204
9044:L-838,417
9034:Imepitoin
9004:CGS-20625
8999:CGS-13767
8984:Adipiplon
8958:Ocinaplon
8920:Saripidem
8915:Necopidem
8892:Zopiclone
8887:Suriclone
8872:Pagoclone
8778:ORG-21465
8773:ORG-20599
8664:Ectylurea
8654:Carbromal
8532:Propoxate
8522:Etomidate
8449:Baicalein
8406:Styramate
8401:Procymate
8371:Lorbamate
8356:Felbamate
8326:Clocental
8298:Zomebazam
8293:Zolazepam
8288:Zapizolam
8283:Uldazepam
8263:Triazolam
8248:Temazepam
8243:Sulazepam
8233:Ro48-8684
8228:Ro48-6791
8223:Ripazepam
8193:Pyrazolam
8168:Pinazepam
8118:Nifoxipam
8103:Midazolam
8098:Mexazolam
8083:Medazepam
8068:Lorazepam
8048:Ketazolam
8043:Irazepine
8033:Iclazepam
8023:Halazepam
8018:Gidazepam
8013:Fosazepam
7933:Estazolam
7928:Elfazepam
7903:Demoxepam
7833:Cinazepam
7813:Camazepam
7783:Avizafone
7705:Thiamylal
7640:Primidone
7570:Heptabarb
7560:Eterobarb
7525:Carbubarb
7422:Triclofos
7321:Brometone
7236:Phase III
7224:Withdrawn
7089:Buspirone
6975:Minaprine
6910:Tedizolid
6905:Safrazine
6880:Octamoxin
6875:Nialamide
6865:Linezolid
6860:Isoniazid
6770:Mianserin
6712:Opipramol
6677:Iprindole
6657:Dosulepin
6622:Amoxapine
6578:Tricyclic
6436:Trazodone
6393:Mianserin
6365:Bupropion
6299:Tofenacin
6241:Indalpine
6190:Specific
6086:Vitamin D
5525:Estradiol
5517:Estranes:
5509:Estrogens
5306:Androgens
5180:Cortisone
4499:Maturitas
4125:207407084
4103:: 88–94.
4011:: 46–54.
3169:257943362
2881:207407077
2859:: 70–78.
2348:CNS Drugs
2176:123095177
1699:Exogenous
1513:Org 21465
1509:Org 20599
1485:analogues
1478:synthetic
1391:Chemistry
1373:clearance
1350:sulfation
1330:reduction
1167:inhibitor
934:pregnancy
895:analgesic
887:cognitive
883:pro-sleep
879:prosexual
871:prosocial
867:rewarding
734:dry mouth
333:Excretion
322:half-life
308:sulfation
292:reduction
159:Routes of
90:Monograph
84:Drugs.com
14853:Medicine
14814:See also
14702:SR-12813
14592:Piperine
14572:Orlistat
14542:Nicotine
14414:Fentanyl
14399:Febantel
14374:Ecopipam
14339:Dinaline
14224:Cafestol
14214:Bosentan
14088:PK-11195
13775:See also
13696:Agonists
13519:Apigenin
13474:ORF-9326
13469:ORF-9371
13381:Unknown:
13077:Tigestol
13072:Tibolone
12830:ORG-2058
12370:DU-41165
12365:DU-41164
12260:Agonists
12180:See also
12122:lecithin
12098:prodrugs
12048:Tramadol
11898:ME-18-MC
11863:Ketamine
11853:Ibogaine
11673:BW284C51
11428:RJR-2429
11418:Pyrantel
11378:Nicotine
11373:Morantel
11363:Lobeline
11328:EVP-6124
11323:EVP-4473
11278:Cytisine
11273:Cotinine
11178:A-84,543
11149:Agonists
11051:See also
11005:ALX-1393
10868:blockers
10849:instead.
10791:Riluzole
10776:picrotin
10766:thebaine
10754:morphine
10623:Daidzein
10613:Corymine
10599:diazepam
10534:5,7-CIQA
10467:iso-THAZ
10413:Caffeine
10279:atropine
10255:Propofol
10214:Ketamine
10104:Alcohols
10079:Propofol
10043:-Proline
10035:-Alanine
9999:-Alanine
9943:Receptor
9868:TCS-1205
9863:TCS-1105
9853:α-Pinene
9826:Valerian
9801:tetronal
9778:Safranal
9727:obovatol
9723:magnolol
9719:honokiol
9549:Alogabat
9544:AA-29504
9493:Synthane
9453:Nitrogen
9433:Kerosine
9413:Gasoline
9403:Ethylene
9343:Centalun
9338:Butylene
9152:Propofol
9114:U-89843A
9094:TGSC01AA
9064:NS-11394
9029:GBLD-345
8994:CGS-9896
8989:CGS-8216
8973:Zaleplon
8968:Taniplon
8948:Indiplon
8943:Fasiplon
8938:Divaplon
8925:Zolpidem
8828:SAGE-872
8823:SAGE-689
8818:SAGE-516
8813:SAGE-324
8808:SAGE-105
8716:Certain
8659:Capuride
8621:Yangonin
8498:baicalin
8494:Skullcap
8484:Luteolin
8459:Catechin
8454:Baicalin
8444:Apigenin
8416:Tybamate
8203:Quazepam
8198:QH-II-66
8178:Prazepam
8158:Oxazolam
8153:Oxazepam
7953:Etizolam
7908:Diazepam
7888:CP-1414S
7853:Clobazam
7843:Clazolam
7730:Valofane
7685:Talbutal
7675:Sigmodal
7580:Hexethal
7475:Barbital
7455:Alphenal
7445:(-)-DMBB
7391:Propanol
7381:Pentanol
7371:Methanol
7313:Alcohols
7162:GABAkine
6840:Benmoxin
6796:Tiazesim
6520:Ketamine
6505:Gepirone
5812:5α-DHDOC
5520:Estetrol
5283:Cortisol
5175:Cortisol
5044:steroids
4858:31649968
4815:17531325
4765:10008079
4757:15380490
4722:20570588
4673:23348009
4624:21538944
4589:25490229
4581:15763596
4561:Steroids
4519:16406399
4480:31782169
4369:Archived
4343:16984997
4226:31649968
4160:16724185
4117:23978486
4079:22259026
4071:19272715
4033:38928854
4025:21600269
3986:37368754
3978:20665558
3940:21262851
3886:17151597
3845:15364541
3801:19423765
3752:23161870
3703:22687885
3651:27156439
3602:11205767
3559:17651807
3464:26195479
3421:12294587
3413:17636008
3364:10496958
3337:28428226
3280:42753647
3272:10698010
3210:22787590
3125:39391626
3117:19092726
3068:16269314
3025:21533709
2990:18346939
2941:20995334
2933:14993039
2873:23948490
2838:23092405
2803:15677716
2744:19656632
2684:12153544
2648:34267503
2594:34594247
2512:22 March
2458:6 August
2427:30447328
2378:30790145
2295:21 March
2289:Archived
2242:21094889
2168:31006078
2090:Archived
2027:DailyMed
1955:54297812
1947:15249131
1909:38249308
1901:12175598
1663:Research
1578:and the
1528:epilepsy
1377:excreted
1208:receptor
1179:subtypes
1078:receptor
1023:receptor
1005:. It is
1000:pregnane
942:sedation
843:insomnia
827:euphoria
823:flushing
819:sedation
774:(GABA).
758:receptor
726:sedation
708:Zulresso
421:DrugBank
385:516-54-1
262:: <5%
189:ATC code
148:Zulresso
126:DailyMed
57:Zulresso
14929:Sterols
14802:Sesamin
14787:Zeranol
14717:Suramin
14487:LOE-908
14179:AMI-193
14093:S-07662
14008:TCPOBOP
13903:Chrysin
13539:PRA-910
13339:LG-2527
13314:SC-8109
13247:(e.g.,
13230:RU-2309
13208:(e.g.,
13015:(e.g.,
12975:(e.g.,
12906:Danazol
12118:Choline
11678:BW-A444
11656:(e.g.,
11649:BNC-210
11637:(e.g.,
11600:ABT-126
11584:(e.g.,
11543:XY-4083
11508:TC-6683
11503:TC-5619
11498:TC-5214
11493:TC-2216
11488:TC-1827
11483:TC-1734
11478:TC-1698
11388:NS-1738
11382:tobacco
11268:Choline
11213:ABT-894
11208:ABT-560
11203:ABT-418
11198:ABT-202
11035:VVZ-368
10902:ASP2535
10798:(e.g.,
10774:(i.e.,
10734:codeine
10732:(e.g.,
10730:Opioids
10702:(e.g.,
10666:(e.g.,
10630:(e.g.,
10589:(e.g.,
10552:RU-5135
10524:(e.g.,
10445:(e.g.,
10403:Brucine
10349:toluene
10311:(e.g.,
10287:cocaine
10277:(e.g.,
10221:(e.g.,
10196:(e.g.,
10190:Ginseng
10177:(e.g.,
10170:D12-116
10153:(e.g.,
10106:(e.g.,
10094:Taurine
10051:-Serine
10017:Glycine
10007:-Serine
9991:Caesium
9949:ligands
9815:borneol
9813:(e.g.,
9805:trional
9795:(e.g.,
9713:(e.g.,
9711:Lignans
9661:(e.g.,
9619:(e.g.,
9564:Bromide
9556:(e.g.,
9539:α-EMTBL
9503:Toluene
9473:Propane
9348:Chloral
9328:Benzene
9308:Acetone
9139:Phenols
9129:Y-23684
9119:U-90042
9104:TPA-023
9089:SX-3228
9074:ROD-188
9059:NS-2710
9054:NS-2664
9039:JM-1232
9024:ELB-139
9019:CTP-354
8905:Alpidem
8504:Wogonin
8479:Linarin
7958:FG-8205
7665:Reposal
7366:Menthol
7326:Butanol
7094:Lithium
6662:Doxepin
6194:and/or
6113:Others:
5752:(e.g.,
5622:Others:
5535:Estriol
5530:Estrone
4849:6804800
4713:3008321
4664:3648625
4471:7018555
4334:1600006
4311:Bibcode
4284:9175386
4253:3281931
4217:6804800
4168:1933116
3931:3063747
3825:Bibcode
3792:2717864
3743:3529379
3694:3489003
3642:5310676
3594:8398145
3550:2386997
3505:9731711
3456:9166735
3404:3905684
3328:5452057
3237:7932175
3076:9833426
3033:8885335
2981:4112568
2911:Bibcode
2771:Bibcode
2735:2898141
2692:9953445
2639:8276990
2585:8477036
2418:6397075
2369:6424603
2233:3139029
1863:9038248
1795:Bibcode
1707:prodrug
1645:diluted
1613:mixture
1610:aqueous
1538:History
1403:steroid
1379:47% in
1282:targets
1116:agonist
1105:nuclear
1094:kainate
948:of the
932:During
919:anxiety
839:syncope
764:of the
752:of the
697:hormone
610:318.501
578:Formula
430:DB11859
396:PubChem
327:9 hours
314:(SULT))
306:(UGT),
298:(AKR),
272:>99%
235:WARNING
205:)
199: (
197:N06AX29
146::
128::
104:a619037
14839:Portal
14309:DHEA-S
14149:AA-861
12330:P1-185
11708:Curare
11625:AQW051
11572:18-MAC
11528:UB-165
11338:GTS-21
11168:5-HIAA
11136:nAChRs
10656:Ginkgo
10546:7-TFQA
10393:αEMBTL
9986:β-AIBA
9748:Niacin
9333:Butane
9286:SL-164
9157:Thymol
9099:TP-003
8980:Others
8783:P1-185
8743:5β-DHP
8738:5α-DHP
8733:3α-DHP
8581:Kavain
8489:Rc-OMe
7219:WHO-EM
6932:Mixed:
6789:Others
6473:Others
6381:NaSSAs
6078:Others
5074:20α,22
4947:Topics
4856:
4846:
4813:
4763:
4755:
4720:
4710:
4671:
4661:
4622:
4587:
4579:
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4341:
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3574:Neuron
3557:
3547:
3503:
3462:
3454:
3419:
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3362:
3335:
3325:
3278:
3270:
3235:
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3198:
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3115:
3074:
3066:
3031:
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2978:
2939:
2931:
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2836:
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2791:
2742:
2732:
2690:
2682:
2646:
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2582:
2425:
2415:
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2366:
2240:
2230:
2220:
2174:
2166:
1953:
1945:
1907:
1899:
1861:
1825:697360
1823:
1816:291203
1813:
1675:, and
1635:, and
1370:plasma
1312:. The
1216:, and
1142:, and
1096:, and
959:in an
909:, and
740:, and
643:SMILES
521:ChEMBL
490:D11149
284:CYP450
232:
141:
124:
13908:CITCO
13449:J1042
13403:SPRMs
13398:Mixed
12096:(and
12078:Xenon
11577:18-MC
11556:(and
11152:(and
11020:NAGly
10993:GlyT2
10892:ACPPB
10880:GlyT1
10834:NMDAR
10572:Tutin
10542:7-TFQ
10538:7-CIQ
10363:Xenon
10309:gases
9607:DEABL
9300:gases
9109:TP-13
8838:THDOC
8728:DHDOC
7189:5-HTP
6753:TeCAs
6414:SARIs
6348:NDRIs
6267:SNRIs
6209:SSRIs
5966:THDOC
5921:DHDOC
4793:arXiv
4761:S2CID
4585:S2CID
4365:(FDA)
4361:U.S.
4164:S2CID
4121:S2CID
4075:S2CID
4029:S2CID
3982:S2CID
3598:S2CID
3460:S2CID
3417:S2CID
3276:S2CID
3165:S2CID
3153:: X.
3121:S2CID
3072:S2CID
3029:S2CID
2937:S2CID
2877:S2CID
2688:S2CID
2452:(FDA)
2448:U.S.
2285:(FDA)
2281:U.S.
2172:S2CID
2148:Drugs
1951:S2CID
1905:S2CID
1625:vials
1570:Names
1385:urine
1381:feces
1009:from
973:fetus
963:from
950:fetus
688:is a
663:InChI
619:JSmol
501:ChEBI
450:83760
410:92786
345:: 42%
343:Urine
340:: 47%
338:Feces
14480:and
14299:DHEA
14063:AITC
13928:DHEA
13683:PAQR
11758:DHβE
11559:NAMs
11155:PAMs
11070:GABA
10847:here
10845:See
10823:Zinc
10786:PMBA
10778:and
10695:NBQX
10447:2-AG
10368:Zinc
10121:tert
10012:GABA
9961:GlyR
8910:DS-1
8542:Kava
8469:EGCG
7405:tert
7397:tert
7300:GABA
7155:SAMe
6595:TCAs
6580:and
6315:NRIs
6177:N06A
6016:DHEA
5650:DHEA
5359:DHEA
4854:PMID
4811:PMID
4753:PMID
4718:PMID
4669:PMID
4620:PMID
4577:PMID
4540:ISBN
4515:PMID
4476:PMID
4403:2019
4377:2019
4339:PMID
4280:PMID
4249:PMID
4222:PMID
4156:PMID
4113:PMID
4067:PMID
4021:PMID
3974:PMID
3958:Glia
3936:PMID
3882:PMID
3841:PMID
3797:PMID
3748:PMID
3699:PMID
3647:PMID
3590:PMID
3555:PMID
3501:PMID
3452:PMID
3409:PMID
3360:PMID
3333:PMID
3268:PMID
3233:PMID
3206:PMID
3196:ISBN
3113:PMID
3064:PMID
3021:PMID
2986:PMID
2929:PMID
2907:1007
2869:PMID
2834:PMID
2799:PMID
2740:PMID
2680:PMID
2644:PMID
2590:PMID
2539:2023
2514:2019
2486:2020
2460:2020
2423:PMID
2374:PMID
2329:2017
2297:2019
2238:PMID
2218:ISBN
2164:PMID
2098:2019
2065:2023
2036:2019
1943:PMID
1897:PMID
1859:PMID
1821:PMID
1703:oral
1651:and
1557:and
1483:and
1352:via
1348:and
1344:via
1326:keto
1303:oral
1188:and
1144:mPRβ
1140:mPRα
1136:mPRδ
1090:AMPA
1086:NMDA
1074:5-HT
1058:GABA
1019:GABA
1007:made
944:and
915:mood
754:GABA
481:KEGG
461:UNII
310:via
302:via
294:via
288:keto
282:Non-
260:Oral
249:data
80:AHFS
67:USAN
14109:PXR
13853:CAR
13673:mPR
9639:DS2
8748:DHT
8464:EGC
7118:),
7006:MAO
6946:MAO
6447:SMS
5961:THB
5916:DHC
4844:PMC
4836:doi
4803:doi
4789:116
4745:doi
4741:189
4708:PMC
4700:doi
4696:641
4659:PMC
4651:doi
4612:doi
4569:doi
4507:doi
4466:PMC
4458:doi
4329:PMC
4319:doi
4307:103
4212:PMC
4204:doi
4148:doi
4144:187
4105:doi
4101:113
4059:doi
4013:doi
4009:191
3966:doi
3926:PMC
3918:doi
3914:337
3872:doi
3833:doi
3821:199
3787:PMC
3779:doi
3775:150
3738:PMC
3730:doi
3726:154
3689:PMC
3681:doi
3637:PMC
3629:doi
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3537:doi
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3399:PMC
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3323:PMC
3315:doi
3260:doi
3229:270
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3155:doi
3103:doi
3056:doi
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2976:PMC
2968:doi
2919:doi
2861:doi
2857:113
2826:doi
2789:PMC
2779:doi
2767:102
2730:PMC
2722:doi
2672:doi
2634:PMC
2624:doi
2580:PMC
2570:doi
2506:NPR
2413:PMC
2405:doi
2364:PMC
2356:doi
2228:PMC
2210:doi
2156:doi
2058:FDA
1935:doi
1931:222
1889:doi
1851:doi
1847:105
1811:PMC
1803:doi
1759:doi
1340:by
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1194:1.3
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1169:of
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967:to
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400:CID
202:WHO
144:FDA
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4852:.
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4503:54
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