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Anxiolytic

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675:. Serotonin and norepinephrine are neurotransmitters that are related to nervous control in mood regulation. The level of these neurotransmitters is regulated by the nerve through reuptake to avoid accumulation of the neurotransmitter at the endings of nerve fibers. By reuptaking the neurotransmitter, the level of neuronal activity will go back down and be ready to go back up upon excitation from a new nerve signal. However the neurotransmitter level of patients with anxiety disorders is usually low or the patients’ nerve fibers are insensitive to the neurotransmitters. SSRIs and SNRIs will then block the channel of reuptake and increase the level of the neurotransmitter. The nerve fibers will inhibit further production of neurotransmitters upon the increase. However the prolonged increase will eventually 732:. SSRIs are the first-line anti-anxiety medications. Serotonin is one of the crucial neurotransmitters in mood enhancement, and increasing serotonin level produces an anti-anxiety effect. SSRIs increase the serotonin level in the brain by inhibiting serotonin uptake pumps on serotonergic systems, without interactions with other receptors and ion channels. SSRIs are beneficial in both acute response and long-term maintenance treatment for both depression and anxiety disorder. 5356: 398:(MAOIs). SSRIs are used in all types of anxiety disorders while SNRIs are used for generalized anxiety disorder (GAD). Both of them are considered as first-line anti-anxiety medications. TCAs are second-line treatment as they cause more significant adverse effects when compared to the first-line treatment. Benzodiazepines are effective in emergent and short-term treatment of anxiety disorders due to their fast onset but carry the risk of dependence. 5377: 4346: 577:(SNRIs) are new generations of antidepressants. They have a much lower adverse effect profile than older antidepressants like monoamine oxidase inhibitors (MAOIs) and tricyclic antidepressant (TCAs). Therefore, SSRIs and SNRIs are now the first-line agent in treating long term anxiety disorders, given their applications and significance in all six types of disorders. 269:
This refers to the fear of staging in social situations where one experiences public observation among people or performs in front of the public. The fears are often unexplained and persistent. The fear could also be attributed to the possible humiliation in front of others due to poor performance or
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is the recommended treatment for anxiety related phobias. Healthcare providers can guide those with anxiety disorder by referring them to self-help resources. Sometimes medication is combined with psychotherapy but research has not found a benefit of combined pharmacotherapy and psychotherapy versus
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are used for acute anxiety and could be added along with current use of SSRIs to stabilize a treatment. Long-term use in treatment plans is not recommended. Different kinds of benzodiazepine will vary in its pharmacological profile, including its strength of effect and time taken for metabolism. The
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Person with OCD would experience compulsive impulses of removing an obsession. One common example is the obsession with impurities or contamination. The person would have compulsion or urge in sterilizing the environment to remove the contamination. Another example is the obsession with orderliness.
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PTSDs develop due to experience of severe trauma or life-threatening events. Specific symptoms include flashbacks to traumatic events triggered during similar situations, as well as avoidance of these situations. The fear of re-experiencing the event is also associated with feelings of helplessness
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like dizziness, headache and flu-like symptoms (fatigue/myalgia/loose stool) may occur if SSRI is stopped suddenly. The brain is incapable of upregulating the receptors to sufficient levels especially after discontinuation of the drugs with short half life like paroxetine. Both fluoxetine and its
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is originally used for high blood pressure and heart diseases. It can also be used to treat anxiety with symptoms like tremor or increased heart rate. They work on the nervous system and alleviate the symptoms as a relief. Propranolol is also commonly used for public speaking when one is nervous.
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Benzodiazepines are used for emergent or short-term management. They are not recommended as the first-line anti-anxiety drugs, but they can be used in combination with SSRIs/SNRIs during the initial treatment stage. Indications include panic disorder, sleep disorders, seizures, acute behavioral
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This disorder specifically refers to the suffering from panic attacks and also the fear of repetitive attacks. Commonly found in agoraphobia patients (the fear of difficulty in leaving a confined venue). Panic attacks are sudden upsurges in anxiety level usually with unexplained reasons.
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Zvejniece, Liga; Vavers, Edijs; Svalbe, Baiba; Veinberg, Grigory; Rizhanova, Kristina; Liepins, Vilnis; Kalvinsh, Ivars; Dambrova, Maija (1 October 2015). "R-phenibut binds to the α2–δ subunit of voltage-dependent calcium channels and exerts gabapentin-like anti-nociceptive effects".
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Llorca, Pierre-Michel; Spadone, Christian; Sol, Olivier; Danniau, Anne; Bougerol, Thierry; Corruble, Emmanuelle; Faruch, Michel; Macher, Jean-Paul; Sermet, Eric; Servant, Dominique (2002). "Efficacy and Safety of Hydroxyzine in the Treatment of Generalized Anxiety Disorder".
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of anxiety disorder remains unknown. There are several contributing factors that are still yet to be proved to cause anxiety disorders. These factors include childhood anxiety, drug induction by central stimulant drugs, metabolic diseases or having depressive disorder.
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are powerful anxiolytics but the risk of abuse and addiction is high. Many experts consider these drugs obsolete for treating anxiety but valuable for the short-term treatment of severe insomnia, though only after benzodiazepines or non-benzodiazepines have failed.
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Different types of anxiety disorders will share some general symptoms while having their own distinctive symptoms. This explains why people with different types of anxiety disorders will respond differently to different classes of anti-anxiety medications.
988:(TCAs) have anxiolytic effects; however, side effects are often more troubling or severe and overdose is dangerous. They are considered effective, but have generally been replaced by antidepressants that cause different adverse effects. Examples include 610:
Antiepileptics are rarely prescribed as an off-label treatment for anxiety disorders and post-traumatic stress disorders. There have been some suggestions that they may help with anxiety symptoms but there is generally a lack of research on its use.
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Volchegorskii, I. A.; Miroshnichenko, I. Yu.; Rassokhina, L. M.; Faizullin, R. M.; Malkin, M. P.; Pryakhina, K. E.; Kalugina, A. V. (2015). "Comparative Analysis of the Anxiolytic Effects of 3-Hydroxypyridine and Succinic Acid Derivatives".
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In order to be more effective on serotonin agonism and avoid anticholinergic and antihistaminergic side effects, selective serotonin reuptake inhibitors (SSRI) were researched and introduced to treat anxiety disorders. The first SSRI,
437:. TCAs can increase the level of norepinephrine and serotonin by inhibiting their reuptake transport proteins. The majority of TCAs exert greater effect on norepinephrine, which leads to side effects like drowsiness and memory loss. 247:
The anxiety symptoms are usually persistent and constant. Patients of this disorder could experience excessive anxiety for a long duration, commonly over six months and the symptoms could occur without any specific triggers.
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and inhibit further nerve signal transduction. The excitability of the nerves then reduces and the nervous system slows down. Therefore, the drug can alleviate symptoms of anxiety disorder and make the person less nervous.
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Buspirone can be useful in GAD but not particularly effective in treating phobias, panic disorder or social anxiety disorders. It is a safer option for long-term use as it does not cause dependence like benzodiazepines.
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is a stimulant drug with anxiolytic properties developed in Russia during the late 1980s. Bromantane acts mainly by facilitating the biosynthesis of dopamine, through indirect genomic upregulation of relevant enzymes
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if BZDs are rapidly discontinued. Tolerance and dependence may occur. The risk of abuse in this class of medication is smaller than in that of barbiturates. Cognitive and behavioral adverse effects are possible.
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has been prescribed off-label for anxiety despite a lack of research evidence supporting such use, although some studies have indicated that it may relieve anxiety symptoms. The potential anxiolytic effect of
1138:(MAOIs) are first-generation antidepressants effective for anxiety treatment but their dietary restrictions, adverse effect profile and availability of newer medications have limited their use. MAOIs include 691:, which is the receptor protein found in the nervous system and is in control of the nervous response. Benzodiazepine will increase the entry of chloride ions into the cells by improving the binding between 280:
Persistent fear towards a specific object, either tangible or intangible. This leads to undeniable avoidance or thought of escape from the object or endurance of the object in immense levels of anxiety.
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originally approved for clinical use by the FDA in 1956. Hydroxyzine has a calming effect which helps ameliorate anxiety. Hydroxyzine efficacy is comparable to benzodiazepines in the treatment of
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The common early side effects of SSRIs include nausea and loose stool, which can be solved by discontinuing the treatment. Headache, dizziness, insomnia are the common early side effects as well.
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Both selective serotonin reuptake inhibitors (SSRI) and serotonin and norepinephrine reuptake inhibitors (SNRI) are reuptake inhibitors of a class of nerve signal transduction chemical called
618:, has been found to be better at treating GAD than a placebo, and comparable effects to benzodiazepines. It has also been shown be potentially efficient in treating social anxiety disorder. 3622:
Owen, David R.; Wood, David M.; Archer, John R. H.; Dargan, Paul I. (2016). "Phenibut (4-amino-3-phenyl-butyric acid): Availability, prevalence of use, desired effects and acute toxicity".
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There are six groups of anti-anxiety medications available that have been proven to be clinically significant in treatment of anxiety disorders. The groups of medications are as follows.
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are atypical antipsychotics which are also effective in GAD and PTSD treatment. However, there is a higher chance of experiencing adverse effects than the other anti-anxiety medications.
2943:"Double-blind randomized controlled study of the efficacy and tolerability of two reversible monoamine oxidase A inhibitors, pirlindole and moclobemide, in the treatment of depression" 2552: 3675:
Cohen, Pieter A.; Ellison, Ross R.; Travis, John C.; Gaufberg, Slava V.; Gerona, Roy (22 September 2021). "Quantity of phenibut in dietary supplements before and after FDA warnings".
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has demonstrated anxiolytic effect comparable to SSRIs while rarely causing or exacerbating anxiety. Mirtazapine's anxiety reduction tends to occur significantly faster than SSRIs.
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and GABA receptors and then the better opening of the channel for chloride ion passage. The high level of chloride ion inside the nerve cells makes the nerve more difficult to
3718: 1956: 1181:. Benzodiazepines are also prescribed in tandem with an antidepressant for the latent period of efficacy associated with many ADs for anxiety disorder. There is risk of 2694: 4016: 2394:"Although antidepressants and anxiolytics are frequently used together to treat depression in the acute phase, how effective is the concomitant use of these drugs?" 464:(Effexor), entered the market in 1993. SNRIs can target serotonin and norepinephrine transporters while avoiding imposing significant effects on other adrenergic (α 6105: 3978: 3804:
Silkina, IV; Gan'shina, TC; Seredin, SB; Mirzoian, RS (2005). "Gabaergic mechanism of cerebrovascular and neuroprotective effects of afobazole and picamilon".
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Bandelow, Borwin; Wedekind, Dirk; Leon, Teresa (2014). "Pregabalin for the treatment of generalized anxiety disorder: A novel pharmacologic intervention".
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used to treated generalized anxiety disorder. If an individual has only recently stopped taking benzodiazepines, buspirone will be less effective.
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Vakhitova, Yu. V.; Yamidanov, R. S.; Vakhitov, V. A.; Seredenin, S. B. (2005). "The effect of ladasten on gene expression in the rat brain".
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Neznamov, GG; Siuniakov, SA; Chumakov, DV; Bochkarev, VK; Seredenin, SB (2001). "Clinical study of the selective anxiolytic agent afobazol".
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has been observed in some pre-clinical trials, but its effectiveness has not yet been proved. Similarly, there is a lack of research on
5159: 5119: 1570:(Afobazole) is an anxiolytic drug launched in Russia in the early 2000s. Its mechanism of action is poorly-defined, with GABAergic, 2333:
Garakani, Amir; Murrough, James W.; Freire, Rafael C.; Thom, Robyn P.; Larkin, Kaitlyn; Buono, Frank D.; Iosifescu, Dan V. (2020).
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may occur. People with anxiety disorders can exhibit fear responses, such as defensive behaviors, high levels of alertness, and
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and used in Eastern Europe. Temgicoluril has an effect on the structure of limbic-reticular activity, particularly on the
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about the change in level. Therefore, the action of both SSRIs and SNRIs will take 4–6 weeks to exert their full effect.
4207:"Why We Like to Drink: A Functional Magnetic Resonance Imaging Study of the Rewarding and Anxiolytic Effects of Alcohol" 2300: 4762: 4625: 3275:
Hoehn-Saric, Rudolf; Merchant, A. F.; Keyser, M. L.; Smith, V. K. (1981). "Effects of Clonidine on Anxiety Disorders".
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and adrenergic activity. Temgicoluril decreases noradrenaline, increases serotonin, and exerts no effect on dopamine.
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If CBT is found ineffective, both the Canadian and American medical associations then suggest the use of medication.
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is indicated for GAD, which has much slower onset but with the advantage of less sedating and withdrawal effects.
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Anxiety is a naturally-occurring emotion and response. When anxiety levels exceed the tolerability of a person,
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has similar anxiolytic effects as benzodiazepine drugs, but does not produce the same levels of sedation and
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Pull, Charles B (2007). "Combined pharmacotherapy and cognitive-behavioural therapy for anxiety disorders".
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Rumyantseva, S. A.; Fedin, A. I.; Sokhova, O. N. (2012). "Antioxidant Treatment of Ischemic Brain Lesions".
85: 5823: 4614: 4396: 4350: 1761: 1749: 1479: 1135: 974: 940: 751: 242: 17: 2274: 739:; for this reason a concurrent benzodiazepine can be used until the anxiolytic effect of the SSRI occurs. 5808: 5225: 1841: 395: 4875: 4364: 3413:
Owen, R.T. (2007). "Pregabalin: Its efficacy, safety and tolerability profile in generalized anxiety".
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Shearer, Steven L. (2007). "Recent Advances in the Understanding and Treatment of Anxiety Disorders".
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The person would manipulate the surroundings including visual presentations to ease their obsession.
2553:"Combination Treatment With Benzodiazepines and SSRIs for Comorbid Anxiety and Depression: A Review" 355:. Anti-anxiety medication can be classified into six types according to their different mechanisms: 391: 3325:"Prior benzodiazepine use and buspirone response in the treatment of generalized anxiety disorder" 6056: 4930: 4608: 4459: 2526: 1757: 1696: 1548: 692: 415: 1812: 1718:. Further, etifoxine does not affect memory and vigilance, and does not induce rebound anxiety, 4967: 4722: 352: 422:. The drug was found to induce euphoria and improve the patient's appetite and sleep quality. 348: 4652: 4588: 4433: 2941:
Tanghe, A.; Geerts, S.; Van Dorpe, J.; Brichard, B.; Bruhwyler, J.; Géczy, J. (August 1997).
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with more consistent psychic and somatic anxiety reduction. Unlike BZDs, it does not disrupt
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active metabolite have a long half life therefore it causes the least withdrawal symptoms.
932: 729: 445:(Prozac), was discovered in 1974 and approved by FDA in 1987. After that, other SSRIs like 2104:"A brief history of the development of antidepressant drugs: From monoamines to glutamate" 8: 5336: 5072: 4858: 4637: 4464: 3288: 3204: 2892:
Montano, C. Brendan; Jackson, W. Clay; Vanacore, Denise; Weisler, Richard (4 July 2023).
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Anti-anxiety medication is any drug that can be taken or prescribed for the treatment of
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SSRIs can increase anxiety initially due to negative feedback through the serotonergic
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Gelder, M, Mayou, R. and Geddes, J. 2005. Psychiatry. 3rd ed. New York: Oxford. pp236.
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reduce anxiety by decreasing heart rate and preventing shaking. Beta blockers include
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2982: 2878: 224:. Those with anxiety disorders may have concurrent psychological disorders, such as 5527: 5341: 5164: 5089: 5077: 5002: 4868: 4747: 4536: 4298: 4263: 4226: 4222: 4218: 4177: 4159: 4115: 4107: 4057: 3962: 3939: 3919: 3867: 3684: 3639: 3631: 3580: 3516: 3500: 3458: 3422: 3399: 3379: 3336: 3284: 3247: 3239: 3200: 3165: 3118: 3072: 3056: 2954: 2905: 2850: 2749: 2733: 2572: 2484: 2405: 2364: 2346: 2215: 2131: 2115: 2069: 2051: 2010: 1994: 1769: 1202: 1186: 970: 721: 672: 332: 221: 217: 205: 113: 4808: 3688: 3426: 3138: 2910: 2893: 2433:
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anxiolytic with similar anxiolytic effectiveness as benzodiazepines but reduced
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that is also a purported anxiolytic. Its chemical structure resembles that of
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Medications that are indicated for both anxiety disorders and depression.
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Anticholinergic side effects like blurred vision, dry mouth, constipation
1005: 977:. SNRIs are as effective as SSRIs in the treatment of anxiety disorders. 962: 654: 643: 593:
disturbance, muscle spasm and premedication and sedation for procedures.
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SSRIs e.g., fluoxetine, sertraline; SNRIs e.g., venlafaxine; MAOIs; TCAs
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and cognitive, memory, and motor impairment. It was marketed briefly in
1447:(Lyrica) produces anxiolytic effect after one week of use comparable to 589:
choice of the benzodiazepine will depend on the corresponding profiles.
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alongside other first-generation antihistamines of the time, such as
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Stahl's essential psychopharmacology : the prescriber's guide
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can measure the anxiolytic effects of alcohol in the human brain.
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Moraczewski, Jordan; Awosika, Ayoola O.; Aedma, Kapil K. (2023),
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are a group of anti-hypertensives which inhibit activity of the
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The first serotonin norepinephrine reuptake inhibitor (SNRI),
5279: 4989: 4484: 3569: 3489:"Phenibut (β-Phenyl-GABA): A Tranquilizer and Nootropic Drug" 2940: 2891: 2557:
Primary Care Companion to The Journal of Clinical Psychiatry
716:(SSRIs) are a class of medications used in the treatment of 4983: 4204: 4096:"Anxioselective anxiolytics: on a quest for the Holy Grail" 3322: 1738: 176: 173: 164: 134: 131: 122: 3674: 2332: 1409:
have demonstrated both anxiolytic and anxiogenic effects.
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Nuss, Philippe; Ferreri, Florian; Bourin, Michel (2019).
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form, and duloxetine, are indicated for the treatment of
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are common adverse side effects of SSRIs. Sometimes they
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Annual Reports in Medicinal Chemistry, Volume 32 p. 319
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Whittlesea, Cate; Hodson, Karen, eds. (7 August 2018).
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nor does it cause cognitive or psychomotor impairment.
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and their related psychological and physical symptoms.
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Vakhitova IuV, Iamidanov RS, Seredinin SB (2004). "".
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Koola, M. M.; Varghese, S. P.; Fawcett, J. A. (2013).
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Anatomical Therapeutic Chemical Classification System
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Van Der Walt, Martie; Keddy, Karen H. (1 June 2021).
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is a reversible MAOI that lacks dietary restriction.
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Antihistamine side effects like sedation, weight gain
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Tooltip Serotonin antagonist and reuptake inhibitors
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Tooltip Serotonin-norepinephrine reuptake inhibitors
3621: 3369: 3225: 146: 140: 5809: 2275:"BuSpar For Anxiety: Is It Right For Me? | Klarity" 137: 4331:CMA & AMA Home medical guides 2012 & 2014 3108: 2779:Anxiety Disorders: A Pocket Guide For Primary Care 2474: 2208:"Rang and Dale's Pharmacology 7th Edition Preface" 1401:could be effective for PTSD. The alpha-2 agonists 1308:Sedation for minor surgical and medical procedures 1272:Status epilepticus/febrile convulsions/convulsions 335:, which may be mediated by neurotransmitters like 5794: 4145: 3752:Biulleten' Eksperimental'noĭ Biologii I Meditsiny 2796:. New York: Nova Science Publishers. p. 58. 2037: 480:, dopamine, or postsynaptic serotonin receptors. 6087: 3806:Eksperimental'naia i Klinicheskaia Farmakologiia 3779:Eksperimental'naia i Klinicheskaia Farmakologiia 3042: 2995: 2836: 2470: 2468: 2466: 2464: 2462: 2328: 2326: 2324: 2322: 2202: 2200: 2198: 2196: 2194: 2192: 2190: 2188: 1980: 1887: 754:approved to treat generalized anxiety disorder. 649: 538:Gabapentin, pregabalin, tiagabine and valproate 429:, was originally developed and studied to be an 5754:Tooltip Selective serotonin reuptake inhibitors 4089: 4087: 2167:, Treasure Island (FL): StatPearls Publishing, 2101: 1883: 1881: 1879: 1877: 1875: 1130: 1112:TCAs may cause drug poisoning in patients with 799:Apathy (caused by decrease in dopamine release) 2527:"Serotonin: What Is It, Function & Levels" 2301:"What is the Best Anticonvulsant for Anxiety?" 2102:Hillhouse, Todd M.; Porter, Joseph H. (2015). 1119: 410:The first monoamine oxidase inhibitor (MAOI), 27:Class of medications used to alleviate anxiety 6106:Drug classes defined by psychological effects 5408: 4372: 3912:Bulletin of Experimental Biology and Medicine 3719:"Adaptol. Summary of Product Characteristics" 3482: 3480: 2459: 2319: 2185: 1816:Drug classes defined by psychological effects 1744: 1652:and anxiolytic drug in Russia under the name 1259:Short term use in insomnia associated anxiety 4387:Major chemical drug groups – based upon the 4247: 4084: 4047: 3152:Hayes, Peggy E.; Schulz, S. Charles (1987). 2641:: CS1 maint: multiple names: authors list ( 2435:Abnormal Psychology: An Integrative Approach 2108:Experimental and Clinical Psychopharmacology 1872: 980: 954:Serotonin–norepinephrine reuptake inhibitors 941:may persist after the cessation of treatment 575:serotonin–norepinephrine reuptake inhibitors 388:serotonin–norepinephrine reuptake inhibitors 5694: 3151: 2602: 2600: 2598: 2596: 2551:Dunlop, Boadie W.; Davis, Paula G. (2008). 2550: 2097: 2095: 2093: 1921: 1919: 1648:is a flavoring food additive marketed as a 1116:, cardiovascular diseases and arrhythmias. 959:Serotonin–norepinephrine reuptake inhibitor 5415: 5401: 4379: 4365: 3477: 3232:Therapeutic Advances in Psychopharmacology 3028:: CS1 maint: location missing publisher ( 2777:John Vanin; James Helsley (19 June 2008). 2606: 1594:agonism thought to have some involvement. 200:agents which increase anxiety. Anxiolytic 4282: 4230: 4181: 4163: 4119: 3743: 3643: 3520: 3251: 3190: 3076: 3045:"Psychopharmacology of anxiety disorders" 2909: 2791: 2753: 2689: 2687: 2576: 2477:"Selective Serotonin Reuptake Inhibitors" 2409: 2368: 2350: 2135: 2073: 2055: 2014: 1983:"Psychopharmacology of anxiety disorders" 4256:Primary Care: Clinics in Office Practice 4093: 2792:Post, Jason W.; Migne, Louis J. (2012). 2593: 2398:Journal of Psychiatry & Neuroscience 2090: 1916: 687:Benzodiazepines bind selectively to the 631:for the treatment of anxiety disorders. 5437: 4253: 4141: 4139: 3036: 1539:(Mebicar) is an anxiolytic produced in 714:Selective serotonin reuptake inhibitors 709:Selective serotonin reuptake inhibitors 571:Selective serotonin reuptake inhibitors 384:selective serotonin reuptake inhibitors 14: 6088: 5494:Tooltip positive allosteric modulators 5477: 5422: 5366:Pharmacological classification systems 4733:Selective estrogen receptor modulators 4152:Neuropsychiatric Disease and Treatment 4017:"Farmak Product Information - Validol" 3955:Neuroscience and Behavioral Physiology 3573:Pharmacology Biochemistry and Behavior 2684: 2426: 1951: 1949: 1947: 1733:is sometimes used as an anxiolytic by 1640: 661: 5396: 5013:Non-steroidal anti-inflammatory drugs 4360: 3486: 3000:(9th ed.). St. Louis, Missouri. 2998:Lehne's pharmacology for nursing care 2770: 2655: 2607:Formulary., Committee, Joint (2014). 2391: 1305:Acute drug-induced dystonic reactions 84: 5829:Tooltip Monoamine oxidase inhibitors 4288: 4136: 3546:"Феномен аминофенилмасляной кислоты" 3412: 3289:10.1001/archpsyc.1981.01780360094011 3205:10.1001/archpsyc.1974.01760170071012 3154:"Beta-blockers in anxiety disorders" 1786:ATC code N05 § N05B Anxiolytics 1752:(CBT) is an effective treatment for 1232: 1169: 1011: 425:The first tricyclic antidepressant, 287:Posttraumatic stress disorder (PTSD) 211: 5814:Tooltip Tetracyclic antidepressants 4626:Angiotensin II receptor antagonists 3860:Doklady Biochemistry and Biophysics 3543: 1944: 1612:aromatic L-amino acid decarboxylase 1357: 1107: 457:(Lexapro) have entered the market. 298:Obsessive–compulsive disorder (OCD) 243:Generalized anxiety disorders (GAD) 24: 3505:10.1111/j.1527-3458.2001.tb00211.x 3451:The Journal of Clinical Psychiatry 3372:Expert Review of Neurotherapeutics 3329:The Journal of Clinical Psychiatry 3049:Dialogues in Clinical Neuroscience 2959:10.1111/j.1600-0447.1997.tb09918.x 2818:"Tricyclic antidepressants (TCAs)" 2220:10.1016/b978-0-7020-3471-8.00064-0 1987:Dialogues in Clinical Neuroscience 1891:Clinical pharmacy and therapeutics 1514:voltage-dependent calcium channels 829:(active enantiomer of citalopram) 757: 666: 580: 564: 528:Buspirone, gepirone, tandospirone 483: 25: 6117: 5799:Tooltip Tricyclic antidepressants 4338: 2738:10.31887/dcns.2017.19.2/bbandelow 2212:Rang &amp Dale's Pharmacology 1369: 1364:central nervous system depression 916: 682: 634: 605: 5375: 5355: 5354: 4344: 4062:10.2165/11319230-000000000-00000 2855:10.2165/00139709-200524030-00013 2722:"Treatment of anxiety disorders" 1672:can have an antianxiety effect. 1412: 1299:Muscle spasm of varied aetiology 1041:for children above six years old 518:Lorazepam, diazepam, alprazolam 196:. This effect is in contrast to 112: 4763:Hypothalamic–pituitary hormones 4325: 4198: 4041: 4009: 3991: 3946: 3902: 3851: 3797: 3770: 3711: 3668: 3615: 3563: 3537: 3441: 3406: 3363: 3316: 3303: 3268: 3219: 3184: 3145: 3123:10.2165/0023210-200923010-00002 3102: 3093: 3061:10.31887/DCNS.2002.4.3/gcassano 2989: 2934: 2885: 2830: 2810: 2785: 2713: 2649: 2544: 2519: 2385: 2293: 2267: 2242: 2214:, Elsevier, pp. xv, 2012, 1999:10.31887/DCNS.2002.4.3/gcassano 1562: 1531: 1157: 703: 4223:10.1523/JNEUROSCI.0086-08.2008 3277:Archives of General Psychiatry 3193:Archives of General Psychiatry 3158:Journal of Affective Disorders 2947:Acta Psychiatrica Scandinavica 2152: 2031: 1974: 1855: 1829:Drugs by psychological effects 1504:, as well as an antagonist at 1466: 326: 204:are used for the treatment of 13: 1: 4515:Thrombolytics / fibrinolytics 4291:Current Opinion in Psychiatry 4003:The Great Soviet Encyclopedia 3689:10.1080/15563650.2021.1973020 3427:10.1358/dot.2007.43.9.1133188 2911:10.1080/00325481.2023.2189868 2726:Generalized Anxiety Disorders 1848: 1791: 1766:obsessive–compulsive disorder 1597: 1439: 1287:, confusion (more in elderly) 1071:Phobic and obsessional states 880:Obsessive-compulsive disorder 841:Obsessive-compulsive disorder 650:Beta-adrenoceptor antagonists 596: 554:Beta-adrenoceptor antagonists 270:awkward social interactions. 5226:Wakefulness-promoting agents 4303:10.1097/YCO.0b013e3280115e52 4094:Skolnick P (November 2012). 3170:10.1016/0165-0327(87)90017-6 1867:Dorland's Medical Dictionary 1762:generalized anxiety disorder 1750:Cognitive behavioral therapy 1706: 1617: 1480:generalized anxiety disorder 1417: 1136:Monoamine oxidase inhibitors 1131:Monoamine oxidase inhibitors 838:Generalized anxiety disorder 396:monoamine oxidase inhibitors 59:Sedative, minor tranquilizer 7: 2161:"Tricyclic Antidepressants" 1779: 1659: 1485: 1120:Tetracyclic antidepressants 313: 10: 6122: 6101:Anxiety disorder treatment 4876:Intravenous immunoglobulin 4112:10.1016/j.tips.2012.08.003 2656:Stahl, Stephen M. (2011). 2610:British National Formulary 1957:"Anxiety: Pharmacotherapy" 1745:Alternatives to medication 1725: 1722:, or withdrawal symptoms. 1675: 1379:sympathetic nervous system 405: 6046: 5950: 5891: 5868: 5739: 5686: 5668: 5475: 5435: 5350: 5306: 5278: 5234: 5043: 4978: 4941: 4889: 4802: 4746: 4706: 4663: 4547: 4483: 4395: 4268:10.1016/j.pop.2007.05.002 3967:10.1007/s11055-012-9646-3 3924:10.1007/s10517-015-2855-3 3872:10.1007/s10628-005-0057-z 3585:10.1016/j.pbb.2015.07.014 2352:10.3389/fpsyt.2020.595584 2057:10.3389/fpsyt.2021.617751 1697:withdrawn from the market 1590:receptor antagonism, and 1397:. The alpha-1 antagonist 1342:Short term use in anxiety 1321:Gastrointestinal disorder 1256:Short term use in anxiety 1193:Benzodiazepines include: 1183:benzodiazepine withdrawal 986:Tricyclic antidepressants 981:Tricyclic antidepressants 392:tricyclic antidepressants 97: 92: 78: 73: 63: 53: 48: 39: 34: 4931:Topoisomerase inhibitors 4615:renin–angiotensin system 4609:Calcium channel blockers 3487:Lapin, Izyaslav (2001). 3384:10.1586/14737175.7.7.769 3244:10.1177/2045125313500982 2613:. Pharmaceutical Press. 1362:Benzodiazepines lead to 1318:Concentration impairment 1177:are prescribed to quell 1074:Adjunctive treatment of 548:Olanzapine, risperidone 382:Antidepressants include 5446:Tooltip 5-HT1A receptor 4211:Journal of Neuroscience 3624:Drug and Alcohol Review 2339:Frontiers in Psychiatry 2044:Frontiers in Psychiatry 1758:social anxiety disorder 969:drugs. Venlafaxine, in 847:Social anxiety disorder 349:gamma-aminobutyric acid 5486:Tooltip GABAA receptor 4723:Hormonal contraception 4653:Bile acid sequestrants 4434:Proton-pump inhibitors 4397:gastrointestinal tract 1516:(VDCCs), similarly to 1349:As all benzodiazepines 558:Propranolol, atenolol 472:, and β), histamine (H 353:central nervous system 2898:Postgraduate Medicine 2843:Toxicological Reviews 1633:, a form of vitamin B 730:personality disorders 677:desensitize the nerve 505:(e.g., SSRIs, SNRIs) 5721:Gabapentin enacarbil 5332:Radiopharmaceuticals 5120:Antiparkinson agents 4353:at Wikimedia Commons 4262:(3): 475–504, v–vi. 4100:Trends Pharmacol Sci 3463:10.4088/JCP.v63n1112 3341:10.4088/jcp.v61n0203 2489:10.1007/164_2018_172 1668:based drugs such as 1608:tyrosine hydroxylase 933:erectile dysfunction 793:Acute angle closure 5115:Antimigraine agents 5105:Antidementia agents 5008:Anti-inflammatories 4698:Medicated dressings 4638:Antihyperlipidemics 4465:Diabetes medication 4165:10.2147/ndt.s200568 4029:on 19 December 2013 3677:Clinical Toxicology 2279:www.klarityadhd.com 1862:"Antianxiety agent" 1646:Menthyl isovalerate 1641:Menthyl isovalerate 1578:release promoting, 1549:γ aminobutyric acid 1281:Decreased alertness 1274:caused by poisoning 1246:Common Side effect 1025:Common side effect 947:Withdrawal symptoms 883:Menopausal symptoms 771:Common side effect 662:Mechanism of action 614:One antiepileptic, 6073:Never to phase III 4968:Immunosuppressants 4838:Antimycobacterials 4794:Antithyroid agents 4778:Mineralocorticoids 4582:Cardiac stimulants 4572:Cardiac glycosides 4564:cardiac therapy / 4460:Anti-obesity drugs 3833:Eksp Klin Farmakol 3731:on 3 December 2015 2701:. 15 February 2021 2392:Kanba, S. (2004). 2281:. 23 November 2022 1842:Psychoactive drugs 1461:sleep architecture 1263:Conscious sedation 1099:Breast enlargement 1068:Depressive illness 925:Sexual dysfunction 835:Depressive illness 783:Depressive illness 190:anti-anxiety agent 6083: 6082: 5655:Ethanol (alcohol) 5563:Ethyl loflazepate 5390: 5389: 5293:Ophthalmologicals 5003:Anabolic steroids 4906:Anticancer agents 4869:Ectoparasiticides 4589:Antihypertensives 4537:Antifibrinolytics 4349:Media related to 3636:10.1111/dar.12356 2669:978-0-521-17364-3 2620:978-0-85711-152-4 2498:978-3-030-10948-6 2444:978-0-495-09556-9 2307:. 28 October 2014 1901:978-0-7020-7012-9 1685:nonbenzodiazepine 1355: 1354: 1324:Movement disorder 1315:Abnormal appetite 1105: 1104: 1044:Severe depression 914: 913: 722:anxiety disorders 673:neurotransmitters 562: 561: 333:anxiety disorders 307: 306: 222:negative emotions 218:anxiety disorders 212:Nature of anxiety 206:anxiety disorders 104: 103: 68:Anxiety disorders 49:Class identifiers 16:(Redirected from 6113: 5919:Alpha-2 agonists 5909:Alpha-1 blockers 5902: 5830: 5826: 5815: 5811: 5800: 5796: 5785: 5781: 5770: 5766: 5755: 5751: 5709: 5703: 5700: 5528:Chlordiazepoxide 5495: 5491: 5487: 5483: 5447: 5443: 5417: 5410: 5403: 5394: 5393: 5379: 5358: 5357: 5342:Senotherapeutics 5196:Neuroprotectives 5191:Mood stabilizers 5090:Anti-ADHD agents 5030:Muscle relaxants 4963:Immunostimulants 4958:Immunomodulators 4790:Thyroid hormones 4728:Fertility agents 4631:Renin inhibitors 4522:Antihemorrhagics 4489:forming organs ( 4475:Dietary minerals 4381: 4374: 4367: 4358: 4357: 4348: 4332: 4329: 4323: 4322: 4286: 4280: 4279: 4251: 4245: 4244: 4234: 4202: 4196: 4195: 4185: 4167: 4143: 4134: 4133: 4123: 4091: 4082: 4081: 4045: 4039: 4038: 4036: 4034: 4028: 4022:. 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5734: 5733: 5728: 5723: 5718: 5712: 5710: 5696: 5688:Gabapentinoids 5684: 5683: 5681: 5680: 5674: 5672: 5666: 5665: 5663: 5662: 5657: 5652: 5647: 5642: 5632: 5622: 5610: 5605: 5600: 5595: 5590: 5585: 5580: 5575: 5570: 5565: 5560: 5555: 5550: 5545: 5540: 5535: 5530: 5525: 5520: 5515: 5510: 5498: 5496: 5479: 5473: 5472: 5470: 5469: 5464: 5459: 5453: 5451: 5439: 5433: 5432: 5420: 5419: 5412: 5405: 5397: 5388: 5387: 5385: 5384: 5373: 5368: 5363: 5351: 5348: 5347: 5345: 5344: 5339: 5334: 5329: 5327:Contrast media 5324: 5318: 5316: 5304: 5303: 5301: 5300: 5295: 5289: 5287: 5280:sensory organs 5276: 5275: 5273: 5272: 5267: 5263: 5258: 5253: 5247: 5245: 5232: 5231: 5229: 5228: 5223: 5218: 5213: 5208: 5203: 5198: 5193: 5188: 5179: 5178: 5177: 5172: 5167: 5157: 5152: 5147: 5142: 5137: 5132: 5127: 5125:Antipsychotics 5122: 5117: 5112: 5107: 5102: 5097: 5095:Antiaddictives 5092: 5087: 5082: 5081: 5080: 5075: 5065: 5059: 5057: 5050:nervous system 5041: 5040: 5038: 5037: 5032: 5027: 5022: 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4384: 4383: 4376: 4369: 4361: 4355: 4354: 4340: 4339:External links 4337: 4334: 4333: 4324: 4281: 4246: 4197: 4135: 4106:(11): 611–20. 4083: 4056:(3): 287–312. 4040: 4008: 3990: 3945: 3901: 3850: 3835:(in Russian). 3823: 3796: 3769: 3754:(in Russian). 3742: 3710: 3683:(4): 486–488. 3667: 3630:(5): 591–596. 3614: 3562: 3536: 3499:(4): 471–481. 3476: 3457:(11): 1020–7. 3440: 3415:Drugs of Today 3405: 3362: 3315: 3302: 3267: 3218: 3183: 3144: 3101: 3092: 3055:(3): 271–285. 3035: 3006: 2988: 2953:(2): 134–141. 2933: 2904:(5): 449–465. 2884: 2849:(3): 205–214. 2829: 2809: 2802: 2784: 2769: 2712: 2683: 2668: 2648: 2619: 2592: 2563:(3): 222–228. 2543: 2518: 2497: 2458: 2443: 2425: 2384: 2318: 2292: 2266: 2241: 2228: 2184: 2151: 2089: 2030: 1993:(3): 271–285. 1973: 1943: 1915: 1900: 1871: 1853: 1852: 1850: 1847: 1836: 1835: 1823: 1822: 1810: 1809: 1797: 1796: 1793: 1790: 1789: 1788: 1781: 1778: 1754:panic disorder 1746: 1743: 1727: 1724: 1708: 1705: 1701:liver toxicity 1677: 1674: 1661: 1658: 1642: 1639: 1634: 1619: 1616: 1599: 1596: 1592:sigma receptor 1587: 1581: 1564: 1561: 1533: 1530: 1518:gabapentinoids 1507: 1496: 1487: 1484: 1468: 1465: 1441: 1438: 1428: 1425:(Buspar) is a 1419: 1416: 1414: 1411: 1375:Sympatholytics 1371: 1370:Sympatholytics 1368: 1359: 1358:Adverse effect 1356: 1353: 1352: 1351: 1350: 1345: 1344: 1343: 1338: 1334: 1333: 1332: 1331: 1328: 1325: 1322: 1319: 1316: 1311: 1310: 1309: 1306: 1303: 1300: 1295: 1291: 1290: 1289: 1288: 1282: 1277: 1276: 1275: 1269: 1266: 1265:for procedures 1260: 1257: 1252: 1248: 1247: 1244: 1241: 1234: 1231: 1171: 1168: 1159: 1156: 1132: 1129: 1121: 1118: 1109: 1106: 1103: 1102: 1101: 1100: 1097: 1092: 1089: 1084: 1083: 1082: 1072: 1069: 1064: 1058: 1057: 1056: 1055: 1052: 1047: 1046: 1045: 1042: 1033: 1027: 1026: 1023: 1020: 1013: 1010: 982: 979: 955: 952: 937:reduced libido 918: 917:Adverse effect 915: 912: 911: 910: 909: 908:Blurred vision 906: 903: 900: 894: 891: 886: 885: 884: 881: 878: 873: 866: 860: 859: 858: 857: 850: 849: 848: 845: 844:Panic disorder 842: 839: 836: 831: 822: 821: 820: 819: 814: 809: 806: 803: 800: 797: 789: 788: 787: 786:Panic disorder 784: 779: 773: 772: 769: 766: 759: 756: 710: 707: 705: 702: 684: 683:Benzodiazepine 681: 668: 665: 663: 660: 651: 648: 636: 635:Antipsychotics 633: 607: 606:Antiepileptics 604: 598: 595: 582: 579: 566: 563: 560: 559: 556: 550: 549: 546: 544:Antipsychotics 540: 539: 536: 534:Antiepileptics 530: 529: 526: 520: 519: 516: 510: 509: 506: 499: 498: 495: 485: 482: 473: 469: 465: 416:antitubercular 407: 404: 373:antipsychotics 369:antiepileptics 351:(GABA) in the 337:norepinephrine 328: 325: 315: 312: 305: 304: 300: 294: 293: 289: 283: 282: 278: 272: 271: 267: 261: 260: 256: 254:Panic disorder 250: 249: 245: 239: 238: 235: 213: 210: 102: 101: 95: 94: 90: 89: 82: 76: 75: 71: 70: 65: 61: 60: 57: 51: 50: 46: 45: 37: 36: 26: 9: 6: 4: 3: 2: 6118: 6107: 6104: 6102: 6099: 6097: 6094: 6093: 6091: 6072: 6070: 6067: 6066: 6064: 6061: 6058: 6055: 6053: 6050: 6049: 6045: 6039: 6036: 6034: 6031: 6029: 6026: 6024: 6021: 6019: 6016: 6014: 6011: 6009: 6008:Phenaglycodol 6006: 6004: 6001: 5999: 5996: 5994: 5991: 5989: 5986: 5984: 5981: 5979: 5976: 5974: 5971: 5969: 5966: 5964: 5961: 5959: 5956: 5955: 5953: 5949: 5942: 5938: 5937:Beta blockers 5935: 5932: 5928: 5924: 5920: 5917: 5914: 5910: 5907: 5906: 5904: 5900: 5894: 5890: 5884: 5881: 5879: 5876: 5875: 5873: 5871: 5867: 5861: 5858: 5856: 5853: 5851: 5848: 5846: 5843: 5841: 5838: 5834: 5827: 5822: 5819: 5812: 5807: 5804: 5797: 5792: 5789: 5782: 5777: 5774: 5767: 5762: 5759: 5752: 5747: 5746: 5744: 5742: 5738: 5732: 5729: 5727: 5724: 5722: 5719: 5717: 5714: 5713: 5711: 5707: 5704: 5689: 5685: 5679: 5676: 5675: 5673: 5671: 5667: 5661: 5658: 5656: 5653: 5651: 5650:Chlormezanone 5648: 5646: 5643: 5640: 5636: 5633: 5630: 5629:phenobarbital 5626: 5623: 5621: 5618: 5614: 5611: 5609: 5606: 5604: 5601: 5599: 5596: 5594: 5591: 5589: 5586: 5584: 5581: 5579: 5576: 5574: 5571: 5569: 5566: 5564: 5561: 5559: 5556: 5554: 5551: 5549: 5546: 5544: 5541: 5539: 5536: 5534: 5531: 5529: 5526: 5524: 5521: 5519: 5516: 5514: 5511: 5509: 5506: 5504: 5500: 5499: 5497: 5492: 5484: 5474: 5468: 5465: 5463: 5460: 5458: 5455: 5454: 5452: 5450: 5444: 5434: 5429: 5425: 5418: 5413: 5411: 5406: 5404: 5399: 5398: 5395: 5383: 5378: 5374: 5372: 5369: 5367: 5364: 5362: 5353: 5352: 5349: 5343: 5340: 5338: 5335: 5333: 5330: 5328: 5325: 5323: 5320: 5319: 5317: 5314: 5310: 5305: 5299: 5296: 5294: 5291: 5290: 5288: 5285: 5281: 5277: 5271: 5264: 5262: 5259: 5257: 5254: 5252: 5251:Decongestants 5249: 5248: 5246: 5243: 5239: 5233: 5227: 5224: 5222: 5219: 5217: 5214: 5212: 5209: 5207: 5204: 5202: 5199: 5197: 5194: 5192: 5189: 5187: 5183: 5180: 5176: 5173: 5171: 5170:Dissociatives 5168: 5166: 5163: 5162: 5161: 5160:Hallucinogens 5158: 5156: 5153: 5151: 5148: 5146: 5143: 5141: 5138: 5136: 5133: 5131: 5128: 5126: 5123: 5121: 5118: 5116: 5113: 5111: 5108: 5106: 5103: 5101: 5098: 5096: 5093: 5091: 5088: 5086: 5083: 5079: 5076: 5074: 5071: 5070: 5069: 5066: 5064: 5061: 5060: 5058: 5055: 5051: 5046: 5042: 5036: 5033: 5031: 5028: 5026: 5023: 5021: 5018: 5014: 5011: 5010: 5009: 5006: 5004: 5001: 5000: 4998: 4995: 4991: 4985: 4981: 4977: 4969: 4966: 4964: 4961: 4960: 4959: 4956: 4955: 4953: 4950: 4944: 4940: 4932: 4929: 4927: 4924: 4922: 4919: 4917: 4914: 4912: 4909: 4908: 4907: 4904: 4903: 4901: 4898: 4892: 4888: 4882: 4879: 4877: 4874: 4870: 4867: 4865: 4864:Anthelmintics 4862: 4860: 4857: 4856: 4855: 4852: 4850: 4847: 4845: 4842: 4839: 4835: 4831: 4828: 4827: 4825: 4822: 4818: 4814: 4810: 4805: 4801: 4795: 4791: 4788: 4786: 4783: 4779: 4776: 4774: 4771: 4770: 4769: 4766: 4764: 4761: 4760: 4758: 4755: 4751: 4745: 4739: 4736: 4734: 4731: 4729: 4726: 4724: 4721: 4720: 4718: 4715: 4711: 4708:genitourinary 4705: 4699: 4696: 4694: 4691: 4689: 4688:Antipruritics 4686: 4684: 4681: 4679: 4676: 4675: 4673: 4670: 4666: 4662: 4654: 4651: 4649: 4646: 4644: 4641: 4640: 4639: 4636: 4632: 4629: 4627: 4624: 4622: 4619: 4618: 4617: 4616: 4612: 4610: 4607: 4605: 4604:Beta blockers 4602: 4600: 4597: 4595: 4592: 4590: 4587: 4583: 4580: 4578: 4575: 4573: 4570: 4569: 4568: 4567: 4562: 4561: 4559: 4556: 4552: 4546: 4538: 4535: 4533: 4530: 4528: 4525: 4524: 4523: 4520: 4516: 4513: 4511: 4508: 4506: 4505:Antiplatelets 4503: 4502: 4501: 4498: 4497: 4495: 4492: 4486: 4482: 4476: 4473: 4471: 4468: 4466: 4463: 4461: 4458: 4456: 4452: 4449: 4447: 4444: 4442: 4439: 4435: 4432: 4430: 4423: 4421: 4418: 4417: 4416: 4413: 4412: 4410: 4407: 4403: 4398: 4394: 4390: 4382: 4377: 4375: 4370: 4368: 4363: 4362: 4359: 4352: 4347: 4343: 4342: 4328: 4320: 4316: 4312: 4308: 4304: 4300: 4296: 4292: 4285: 4277: 4273: 4269: 4265: 4261: 4257: 4250: 4242: 4238: 4233: 4228: 4224: 4220: 4216: 4212: 4208: 4201: 4193: 4189: 4184: 4179: 4175: 4171: 4166: 4161: 4158:: 1781–1795. 4157: 4153: 4149: 4142: 4140: 4131: 4127: 4122: 4117: 4113: 4109: 4105: 4101: 4097: 4090: 4088: 4079: 4075: 4071: 4067: 4063: 4059: 4055: 4051: 4044: 4025: 4018: 4012: 4004: 4000: 3994: 3986: 3980: 3976: 3972: 3968: 3964: 3960: 3956: 3949: 3941: 3937: 3933: 3929: 3925: 3921: 3918:(6): 756–61. 3917: 3913: 3905: 3897: 3893: 3889: 3885: 3881: 3877: 3873: 3869: 3865: 3861: 3854: 3846: 3842: 3838: 3834: 3827: 3819: 3815: 3811: 3807: 3800: 3792: 3788: 3784: 3780: 3773: 3765: 3761: 3758:(5): 568–70. 3757: 3753: 3746: 3727: 3720: 3714: 3706: 3702: 3698: 3694: 3690: 3686: 3682: 3678: 3671: 3663: 3659: 3655: 3651: 3646: 3645:10044/1/30073 3641: 3637: 3633: 3629: 3625: 3618: 3610: 3606: 3602: 3598: 3594: 3590: 3586: 3582: 3578: 3574: 3566: 3551: 3547: 3540: 3532: 3528: 3523: 3518: 3514: 3510: 3506: 3502: 3498: 3494: 3490: 3483: 3481: 3472: 3468: 3464: 3460: 3456: 3452: 3444: 3436: 3432: 3428: 3424: 3421:(9): 601–10. 3420: 3416: 3409: 3401: 3397: 3393: 3389: 3385: 3381: 3378:(7): 769–81. 3377: 3373: 3366: 3358: 3354: 3350: 3346: 3342: 3338: 3334: 3330: 3326: 3319: 3313: 3312: 3306: 3298: 3294: 3290: 3286: 3282: 3278: 3271: 3263: 3259: 3254: 3249: 3245: 3241: 3237: 3233: 3229: 3222: 3214: 3210: 3206: 3202: 3199:(5): 681–91. 3198: 3194: 3187: 3179: 3175: 3171: 3167: 3164:(2): 119–30. 3163: 3159: 3155: 3148: 3140: 3136: 3132: 3128: 3124: 3120: 3116: 3112: 3105: 3096: 3088: 3084: 3079: 3074: 3070: 3066: 3062: 3058: 3054: 3050: 3046: 3039: 3031: 3025: 3017: 3013: 3009: 3007:9780323321907 3003: 2999: 2992: 2984: 2980: 2976: 2972: 2968: 2964: 2960: 2956: 2952: 2948: 2944: 2937: 2929: 2925: 2921: 2917: 2912: 2907: 2903: 2899: 2895: 2888: 2880: 2876: 2872: 2868: 2864: 2860: 2856: 2852: 2848: 2844: 2840: 2833: 2825: 2824: 2819: 2813: 2805: 2803:9781620815557 2799: 2795: 2788: 2780: 2773: 2765: 2761: 2756: 2751: 2747: 2743: 2739: 2735: 2732:(2): 93–107. 2731: 2727: 2723: 2716: 2700: 2696: 2690: 2688: 2679: 2675: 2671: 2665: 2661: 2660: 2652: 2644: 2638: 2630: 2626: 2622: 2616: 2612: 2611: 2603: 2601: 2599: 2597: 2588: 2584: 2579: 2574: 2570: 2566: 2562: 2558: 2554: 2547: 2532: 2528: 2522: 2508: 2504: 2500: 2494: 2490: 2486: 2482: 2478: 2471: 2469: 2467: 2465: 2463: 2454: 2450: 2446: 2440: 2436: 2429: 2421: 2417: 2412: 2407: 2403: 2399: 2395: 2388: 2380: 2376: 2371: 2366: 2362: 2358: 2353: 2348: 2344: 2340: 2336: 2329: 2327: 2325: 2323: 2306: 2305:Psych Central 2302: 2296: 2280: 2276: 2270: 2255: 2251: 2245: 2231: 2229:9780702034718 2225: 2221: 2217: 2213: 2209: 2203: 2201: 2199: 2197: 2195: 2193: 2191: 2189: 2174: 2170: 2166: 2162: 2155: 2147: 2143: 2138: 2133: 2129: 2125: 2121: 2117: 2113: 2109: 2105: 2098: 2096: 2094: 2085: 2081: 2076: 2071: 2067: 2063: 2058: 2053: 2049: 2045: 2041: 2034: 2026: 2022: 2017: 2012: 2008: 2004: 2000: 1996: 1992: 1988: 1984: 1977: 1962: 1958: 1952: 1950: 1948: 1932: 1928: 1922: 1920: 1911: 1907: 1903: 1897: 1893: 1892: 1884: 1882: 1880: 1878: 1876: 1869: 1868: 1863: 1858: 1854: 1843: 1839: 1830: 1826: 1817: 1813: 1804: 1800: 1787: 1784: 1783: 1777: 1774: 1773:monotherapy. 1771: 1767: 1763: 1759: 1755: 1751: 1742: 1740: 1736: 1732: 1723: 1721: 1717: 1713: 1704: 1702: 1698: 1694: 1690: 1686: 1682: 1673: 1671: 1667: 1657: 1655: 1651: 1647: 1638: 1632: 1628: 1624: 1615: 1613: 1609: 1604: 1595: 1593: 1585: 1577: 1573: 1569: 1560: 1558: 1554: 1550: 1546: 1542: 1538: 1529: 1527: 1523: 1519: 1515: 1511: 1503: 1500: 1492: 1483: 1481: 1477: 1476:antihistamine 1473: 1464: 1462: 1458: 1454: 1450: 1446: 1437: 1435: 1432: 1424: 1413:Miscellaneous 1410: 1408: 1404: 1400: 1396: 1392: 1388: 1384: 1383:Beta blockers 1380: 1376: 1367: 1365: 1348: 1347: 1346: 1341: 1340: 1339: 1336: 1335: 1329: 1326: 1323: 1320: 1317: 1314: 1313: 1312: 1307: 1304: 1301: 1298: 1297: 1296: 1293: 1292: 1286: 1283: 1280: 1279: 1278: 1273: 1270: 1268:Premedication 1267: 1264: 1261: 1258: 1255: 1254: 1253: 1250: 1249: 1245: 1242: 1239: 1238: 1230: 1228: 1224: 1220: 1216: 1212: 1208: 1204: 1200: 1196: 1191: 1188: 1184: 1180: 1179:panic attacks 1176: 1167: 1164: 1155: 1153: 1149: 1145: 1144:isocarboxazid 1141: 1137: 1128: 1126: 1117: 1115: 1098: 1096: 1093: 1090: 1087: 1086: 1085: 1081: 1077: 1073: 1070: 1067: 1066: 1065: 1063: 1060: 1059: 1053: 1050: 1049: 1048: 1043: 1040: 1036: 1035: 1034: 1032: 1029: 1028: 1024: 1021: 1018: 1017: 1009: 1007: 1003: 1002:nortriptyline 999: 998:amitriptyline 995: 991: 987: 978: 976: 972: 968: 964: 960: 951: 948: 944: 942: 938: 934: 930: 926: 922: 907: 904: 901: 899: 895: 892: 889: 888: 887: 882: 879: 877: 874: 872: 869: 868: 867: 865: 862: 861: 856: 853: 852: 851: 846: 843: 840: 837: 834: 833: 832: 830: 827: 824: 823: 818: 815: 813: 810: 807: 804: 801: 798: 796: 792: 791: 790: 785: 782: 781: 780: 778: 775: 774: 770: 767: 764: 763: 755: 753: 749: 745: 740: 738: 737:autoreceptors 733: 731: 727: 723: 719: 715: 701: 698: 694: 690: 689:GABA receptor 680: 678: 674: 659: 656: 647: 645: 641: 632: 630: 626: 621: 617: 612: 603: 594: 590: 587: 578: 576: 572: 557: 555: 552: 551: 547: 545: 542: 541: 537: 535: 532: 531: 527: 525: 522: 521: 517: 515: 512: 511: 507: 504: 501: 500: 496: 493: 492: 489: 481: 479: 463: 458: 456: 453:(Paxil), and 452: 448: 444: 438: 436: 432: 431:antihistamine 428: 423: 421: 417: 413: 403: 401: 397: 393: 389: 385: 380: 378: 377:beta blockers 374: 370: 366: 362: 358: 354: 350: 346: 342: 338: 334: 324: 321: 311: 301: 299: 296: 295: 290: 288: 285: 284: 279: 277: 274: 273: 268: 266: 265:Social phobia 263: 262: 257: 255: 252: 251: 246: 244: 241: 240: 236: 233: 232: 229: 227: 223: 219: 209: 207: 203: 199: 195: 191: 187: 181: 109: 100: 96: 91: 87: 83: 81: 77: 74:Clinical data 72: 69: 66: 62: 58: 56: 52: 47: 44: 43: 38: 33: 30: 19: 5978:Lorpiprazole 5968:Fabomotizole 5958:Benzoctamine 5860:Vortioxetine 5836: 5803:clomipramine 5758:escitalopram 5645:Carisoprodol 5625:Barbiturates 5616: 5501: 5467:Tandospirone 5423: 5165:Psychedelics 5135:Aphrodisiacs 5129: 4809:infestations 4785:Sex hormones 4738:Sex hormones 4683:Cicatrizants 4613: 4599:Vasodilators 4566:antianginals 4563: 4415:stomach acid 4414: 4327: 4294: 4290: 4284: 4259: 4255: 4249: 4214: 4210: 4200: 4155: 4151: 4103: 4099: 4053: 4049: 4043: 4031:. Retrieved 4024:the original 4011: 4002: 3993: 3961:(8): 842–5. 3958: 3954: 3948: 3915: 3911: 3904: 3863: 3859: 3853: 3836: 3832: 3826: 3809: 3805: 3799: 3782: 3778: 3772: 3755: 3751: 3745: 3733:. Retrieved 3726:the original 3713: 3680: 3676: 3670: 3627: 3623: 3617: 3576: 3572: 3565: 3553:. Retrieved 3549: 3539: 3496: 3492: 3454: 3450: 3443: 3418: 3414: 3408: 3375: 3371: 3365: 3335:(2): 91–94. 3332: 3328: 3318: 3310: 3305: 3280: 3276: 3270: 3235: 3231: 3221: 3196: 3192: 3186: 3161: 3157: 3147: 3117:(1): 19–34. 3114: 3110: 3104: 3095: 3052: 3048: 3038: 2997: 2991: 2950: 2946: 2936: 2901: 2897: 2887: 2846: 2842: 2832: 2821: 2812: 2793: 2787: 2778: 2772: 2729: 2725: 2715: 2703:. Retrieved 2698: 2658: 2651: 2609: 2560: 2556: 2546: 2534:. Retrieved 2530: 2521: 2510:, retrieved 2480: 2434: 2428: 2401: 2397: 2387: 2342: 2338: 2309:. Retrieved 2304: 2295: 2283:. Retrieved 2278: 2269: 2257:. Retrieved 2253: 2244: 2233:, retrieved 2211: 2176:, retrieved 2164: 2154: 2111: 2107: 2047: 2043: 2033: 1990: 1986: 1976: 1964:. Retrieved 1960: 1934:. Retrieved 1930: 1894:. Elsevier. 1890: 1865: 1857: 1775: 1748: 1729: 1710: 1679: 1663: 1653: 1644: 1621: 1601: 1568:Fabomotizole 1566: 1563:Fabomotizole 1545:hypothalamus 1537:Temgicoluril 1535: 1532:Temgicoluril 1512:-containing 1489: 1470: 1443: 1421: 1373: 1361: 1327:Muscle spasm 1209:(Klonopin), 1192: 1173: 1163:Barbiturates 1161: 1158:Barbiturates 1134: 1123: 1111: 1062:Clomipramine 984: 957: 945: 923: 920: 905:Vasodilation 828: 826:Escitalopram 748:escitalopram 741: 734: 712: 704:Clinical use 686: 670: 653: 638: 613: 609: 600: 591: 584: 573:(SSRIs) and 568: 487: 459: 455:escitalopram 439: 435:promethazine 424: 409: 394:(TCAs), and 381: 330: 317: 308: 237:Description 215: 189: 185: 107: 105: 93:Legal status 86:Drug Classes 40: 29: 18:Anti-anxiety 6096:Anxiolytics 6059:from market 5988:Mepiprazole 5973:Hydroxyzine 5963:Cycloserine 5941:propranolol 5883:Flupentixol 5840:Agomelatine 5818:mirtazapine 5639:meprobamate 5573:Fludiazepam 5548:Clotiazepam 5543:Clorazepate 5424:Anxiolytics 5298:Otologicals 5270:antagonists 5236:respiratory 5211:Orexigenics 5206:Neurotoxins 5155:Euphoriants 5145:Entactogens 5140:Depressants 5130:Anxiolytics 5068:Anesthetics 4844:Antifungals 4441:Antiemetics 4429:antagonists 4351:Anxiolytics 4297:(1): 30–5. 3839:(4): 7–11. 3812:(1): 20–4. 3785:(2): 15–9. 3555:19 December 3238:(1): 43–7. 2823:Mayo Clinic 2114:(1): 1–21. 1803:Anxiolytics 1627:antioxidant 1586:agonism, MT 1472:Hydroxyzine 1467:Hydroxyzine 1457:venlafaxine 1387:propranolol 1337:Alprazolam 1243:Indication 1205:(Librium), 1125:Mirtazapine 1114:hypotension 1095:Arrhythmias 1022:Indication 1006:desipramine 963:venlafaxine 768:Indication 655:Propranolol 644:risperidone 494:Drug Class 462:venlafaxine 327:Medications 292:or horror. 202:medications 99:In Wikidata 6090:Categories 6003:Oxaflozane 5931:guanfacine 5878:Quetiapine 5855:Vilazodone 5850:Tianeptine 5833:phenelzine 5773:duloxetine 5731:Pregabalin 5716:Gabapentin 5635:Carbamates 5598:Nordazepam 5553:Cloxazolam 5538:Clonazepam 5518:Bromazepam 5513:Alprazolam 5508:Adinazolam 5221:Stimulants 5201:Nootropics 5175:Deliriants 5150:Entheogens 5085:Anorectics 5063:Analgesics 4916:Alkylating 4849:Antivirals 4804:infections 4678:Emollients 4532:Coagulants 4402:metabolism 3550:www.rmj.ru 2705:15 January 2536:15 January 2404:(6): 485. 2311:19 October 2285:19 October 2259:15 January 2178:15 January 2165:StatPearls 2050:: 617751. 1966:15 January 1936:15 January 1910:1084882482 1849:References 1792:Categories 1670:aniracetam 1631:pyridoxine 1603:Bromantane 1598:Bromantane 1526:pregabalin 1522:gabapentin 1453:alprazolam 1445:Pregabalin 1440:Pregabalin 1407:guanfacine 1395:metoprolol 1391:oxprenolol 1251:Lorazepam 1217:(Ativan), 1213:(Valium), 1207:clonazepam 1199:bromazepam 1195:alprazolam 1152:Pirlindole 1140:phenelzine 1088:Aggression 1080:narcolepsy 1037:Nocturnal 1031:Imipramine 990:imipramine 967:duloxetine 929:anorgasmia 898:hemorrhage 864:Fluoxetine 805:Drowsiness 802:Flatulence 777:Citalopram 744:paroxetine 742:The SSRIs 718:depression 697:depolarize 640:Olanzapine 620:Gabapentin 616:pregabalin 597:Azapirones 524:Azapirones 478:muscarinic 451:paroxetine 449:(Zoloft), 447:sertraline 443:fluoxetine 427:imipramine 412:iproniazid 365:azapirones 226:depression 198:anxiogenic 108:anxiolytic 42:Drug class 35:Anxiolytic 6069:Phase III 6057:Withdrawn 6038:Validolum 6033:Tofisopam 6028:Tiagabine 6018:Picamilon 5998:Opipramol 5923:clonidine 5845:Bupropion 5788:trazodone 5678:Zopiclone 5670:Hypnotics 5660:Etifoxine 5608:Pinazepam 5593:Medazepam 5588:Lorazepam 5583:Ketazolam 5578:Halazepam 5523:Camazepam 5457:Buspirone 5371:ATC codes 5337:Dressings 5322:Antidotes 5186:Sedatives 5182:Hypnotics 4891:malignant 4748:endocrine 4594:Diuretics 4527:Platelets 4487:and blood 4446:Laxatives 4174:1178-2021 3999:"Validol" 3880:1607-6729 3705:237594860 3654:1465-3362 3593:0091-3057 3579:: 23–29. 3513:1527-3458 3349:0160-6689 3111:CNS Drugs 3069:1294-8322 3024:cite book 3016:890310283 2967:0001-690X 2920:0032-5481 2863:1176-2551 2746:2608-3477 2678:701672553 2637:cite book 2629:874322467 2569:1523-5998 2453:192055408 2361:1664-0640 2128:1936-2293 2066:1664-0640 2007:1294-8322 1712:Etifoxine 1707:Etifoxine 1623:Emoxypine 1618:Emoxypine 1614:(AAAD)). 1610:(TH) and 1557:serotonin 1510:δ subunit 1449:lorazepam 1423:Buspirone 1418:Buspirone 1403:clonidine 1294:Diazepam 1227:Triazolam 1223:temazepam 1215:lorazepam 1197:(Xanax), 1076:cataplexy 855:Sinusitis 728:and some 629:valproate 625:tiagabine 497:Examples 420:isoniazid 400:Buspirone 390:(SNRIs), 386:(SSRIs), 341:serotonin 186:antipanic 80:Drugs.com 6013:Phenibut 5993:Nicotine 5913:prazosin 5726:Phenibut 5706:blockers 5613:Prazepam 5603:Oxazepam 5568:Etizolam 5558:Diazepam 5533:Clobazam 5462:Gepirone 5449:agonists 5216:Serenics 4881:Vaccines 4648:Fibrates 4470:Vitamins 4420:Antacids 4319:43737803 4311:17143079 4276:17868756 4241:18448634 4192:31308671 4130:22981367 4078:12176745 4070:20166767 3985:26388033 3975:39971165 3932:25894772 3896:28048257 3888:15999825 3845:15500036 3818:15786959 3791:11548440 3697:34550038 3662:26693960 3609:42606053 3601:26234470 3531:11830761 3471:12444816 3435:17940637 3392:17610384 3357:10732655 3262:24490030 3131:19062773 3087:22033867 2983:23485112 2928:36912037 2879:44532041 2871:16390222 2764:28867934 2587:18615162 2512:16 March 2507:30838457 2420:15644990 2379:33424664 2235:16 March 2173:32491723 2146:25643025 2084:34140898 2025:22033867 1780:See also 1768:, while 1695:but was 1689:sedation 1660:Racetams 1650:sedative 1584:receptor 1551:(GABA), 1499:receptor 1491:Phenibut 1486:Phenibut 1431:receptor 1399:prazosin 1330:Vomiting 1219:oxazepam 1211:diazepam 1039:enuresis 817:Rhinitis 812:Migraine 795:glaucoma 345:dopamine 320:etiology 314:Etiology 55:Synonyms 5983:Mebicar 5939:(e.g., 5921:(e.g., 5911:(e.g., 5837:Others: 5831:(e.g., 5816:(e.g., 5801:(e.g., 5786:(e.g., 5771:(e.g., 5756:(e.g., 5637:(e.g., 5627:(e.g., 5620:Alpidem 5617:Others: 5073:General 4980:muscles 4949:L03–L04 4945:disease 4897:L01–L02 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Index

Anti-anxiety
Drug class
Synonyms
Anxiety disorders
Drugs.com
Drug Classes
In Wikidata
/ˌæŋksiəˈlɪtɪk,ˌæŋksi-/
anxiety
anxiogenic
medications
anxiety disorders
anxiety disorders
negative emotions
depression
Generalized anxiety disorders (GAD)
Panic disorder
Social phobia
Specific phobias
Posttraumatic stress disorder (PTSD)
Obsessive–compulsive disorder (OCD)
etiology
anxiety disorders
norepinephrine
serotonin
dopamine
gamma-aminobutyric acid
central nervous system
antidepressants
benzodiazepines

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