340:, limb gangrene, and purple toe syndrome. Skin necrosis and limb gangrene are most commonly observed on the third to eighth day of therapy. The exact pathogenesis of skin necrosis and limb gangrene is not completely understood but it is believed to be associated with warfarin's effect on inhibiting the production of protein C and protein S. Purple toe syndrome typically develops three to eight weeks after initiation of warfarin therapy. Other adverse effects of warfarin are associated with depletion of vitamin K, which can lead to inhibition of G1a proteins and growth arrest-specific gene 6, which can lead to increased risk of arterial calcification and heart valve, especially if too much Vitamin D is present. Warfarin's interference with G1a proteins has also been linked to abnormalities in fetal bone development in mothers who were treated with warfarin during pregnancy. Long-term warfarin and heparin usage have also been linked to osteoporosis.
982:(for factor Xa inhibitor) have been used in clinical settings with varying efficacy. Idarucizumab is a monoclonal antibody, approved by the US FDA in 2015, that reverses the effect of dabigatran by binding to both free and thrombin-bound dabigatran. Andexanet alfa is a recombinant modified human factor Xa decoy that reverses the effect of factor Xa inhibitors by binding at the active sites of factor Xa inhibitor and making it catalytically inactive. Andexanet alfa was approved by the US FDA in 2018. Another drug called ciraparantag, a potential reversal agent for direct factor Xa inhibitors, is still under investigation. Additionally, hemostatic reversal agents have also been used with varying efficacy to reverse the effects of DOACs.
51:
329:
incidence of bleeding of 15-20% per year and a life-threatening bleeding rate of 1-3% per year. Newer non-vitamin K antagonist oral anticoagulants appear to have fewer life-threatening bleeding events than warfarin. Additionally, patients aged 80 years or more may be especially susceptible to bleeding complications, with a rate of 13 bleeds per 100 person-years. Bleeding risk is especially important to consider in patients with renal impairment and NOAC therapy because all NOACs, to some extent, are excreted by the kidneys. Thus, patients with renal impairment may be at higher risk of increased bleeding.
800:(PD0348292) from Pfizer. Betrixaban is significant as it was in 2018, the only oral factor Xa inhibitor approved by the FDA for use in acutely medically ill patients. Darexaban development was discontinued in September 2011; in a trial for prevention of recurrences of myocardial infarction in addition to dual antiplatelet therapy (DAPT), the drug did not demonstrate effectiveness, and the risk of bleeding was increased by approximately 300%. The development of letaxaban for acute coronary syndrome was discontinued in May 2011 following negative results from a Phase II study.
1227:) far outweigh the consequences of prolonged bleeding, which can be controlled with local measures. In patients with other existing medical conditions that can increase the risk of prolonged bleeding after dental treatment or receiving other therapy that can increase bleeding risk, dental practitioners may wish to consult the patient's physician to determine whether care can safely be delivered in a primary care office. Any suggested modification to the medication regimen before dental surgery should be done in consultation and on the advice of the patient's physician.
1231:
to the anticoagulant regimen is required. In patients deemed to be at higher risk of bleeding (e.g., patients with other medical conditions or undergoing more extensive procedures associated with higher bleeding risk), consideration may be given, in consultation with and on advice of the patient's physician, to postponing the timing of the daily dose of the anticoagulant until after the procedure; timing the dental intervention as late as possible after last dose of anticoagulant; or temporarily interrupting drug therapy for 24 to 48 hours.
8812:
8833:
967:
for reversal exist due to a longer history of use of warfarin and the ability to get a more accurate measurement of anticoagulation effect in a patient via measuring the INR (International
Normalized Ratio). In general, vitamin K is most commonly used to reverse the effect of warfarin in non-urgent settings. However, in urgent settings or settings with extremely high INR (INR >20), hemostatic reversal agents such as fresh frozen plasma (FFP),
871:
continued by the patient to avoid any increase in the risk of a thromboembolic event. For dental procedures with a higher risk of bleeding complications (i.e. complex extractions, adjacent extractions leading to a large wound, or more than three extractions), the recommended practice is for the patient to miss or delay a dose of their DOAC before such procedures to minimize the effect on bleeding risk.
1898:...in a market now dominated by one of the oldest mainstay pills in medicine: the blood thinner warfarin. At least five next-generation blood thinners are in advanced testing to treat or prevent potentially debilitating or life-threatening blood clots in surgery and heart patients. First candidates could reach the market in 2009.
483:. Excessive intake of the food mentioned above should be avoided while taking anticoagulants, or if coagulability is being monitored, their intake should be kept approximately constant so that anticoagulant dosage can be maintained at a level high enough to counteract this effect without fluctuations in coagulability.
750:
Both DOACs and warfarin are equivalently effective, but compared to warfarin, DOACs have fewer drug interactions, no known dietary interactions, a wider therapeutic index, and have conventional dosing that does not require dose adjustments with constant monitoring. However, there is no countermeasure
328:
The most serious and common adverse side effects associated with anticoagulants are increased risk of bleeding, both nonmajor and major bleeding events. The bleeding risk depends on the class of anticoagulant agent used, the patient's age, and pre-existing health conditions. Warfarin has an estimated
4798:
Things have changed dramatically with the introduction of the new oral anticoagulants (NOACs) — dabigatran, a factor IIa (thrombin) inhibitor, and the factor Xa inhibitors rivaroxaban and apixaban. Clinical trials have shown them therapeutically superior, or at least non-inferior, to VKAs, with less
1043:
is in liquid form in the tube and is used for coagulation tests and blood transfusion bags. It binds calcium but not as strongly as EDTA. The correct proportion of this anticoagulant to blood is crucial because of the dilution, which can be reversed with the addition of calcium. Formulations include
1230:
Based on limited evidence, the consensus appears to be that in most patients who are receiving the newer direct-acting oral anticoagulants (i.e., dabigatran, rivaroxaban, apixaban, or edoxaban) and undergoing dental treatment (in conjunction with usual local measures to control bleeding), no change
966:
With the growing number of patients taking oral anticoagulation therapy, studies into reversal agents are gaining increasing interest due to major bleeding events and the need for urgent anticoagulant reversal therapy. Reversal agents for warfarin are more widely studied, and established guidelines
870:
Recommendations of modifications to the usage/dosage of DOACs before dental treatments are made based on the balance of the bleeding risk of each procedure and also the individual's own bleeding risks and renal functionality. With low-bleeding-risk dental procedures, it is recommended that DOACs be
343:
Another potentially severe complication associated with heparin use is called heparin-induced thrombocytopenia (HIT). There are two distinct types: HIT 1) immune-mediated and 2) non-immune-mediated. Immune-mediated HIT most commonly arises five to ten days after exposure to heparin. Pathogenesis of
1071:
Dental practitioners play an important role in the early detection of anticoagulant overdose through oral manifestations, as the patient does not show any symptoms. Dental treatment of patients taking anticoagulant or antiplatelet medication raises safety concerns in terms of the potential risk of
866:
methods to minimize bleeding risk during the operation as well as postoperatively. However, with regards to DOACs and invasive dental treatments, there has not been enough clinical evidence and experience to prove any reliable adverse effects, relevance or interaction between these two. Further
746:
Compared to warfarin, DOACs have a rapid onset action and relatively short half-lives; hence, they carry out their function more rapidly and effectively, allowing drugs to reduce their anticoagulation effects quickly. Routine monitoring and dose adjustments of DOACs are less important than for
332:
In people with cancer, a systematic review has found warfarin had no effect on death rate or the risk of blood clots. However, it did increase the risk of major bleeding in 107 more people per 1000 population and minor bleeding in 167 more people per 1000 population. Apixaban had no effect on
212:
drugs by manipulating the various pathways of blood coagulation. Specifically, antiplatelet drugs inhibit platelet aggregation (clumping together), whereas anticoagulants inhibit specific pathways of the coagulation cascade, which happens after the initial platelet aggregation but before the
2960:
Ageno W, Mantovani LG, Haas S, Kreutz R, Monje D, Schneider J, et al. (January 2016). "Safety and effectiveness of oral rivaroxaban versus standard anticoagulation for the treatment of symptomatic deep-vein thrombosis (XALIA): an international, prospective, non-interventional study".
755:, is currently available and approved for use by the FDA. Rates of adherence to DOACs are only modestly higher than adherence to warfarin among patients prescribed these drugs. Thus, adherence to anticoagulation is often poor despite hopes that DOACs would lead to higher adherence rates.
228:
The use of anticoagulants is a decision based on the risks and benefits of anticoagulation. The biggest risk of anticoagulation therapy is the increased risk of bleeding. In otherwise healthy people, the increased risk of bleeding is minimal, but those who have had recent surgery,
747:
warfarin, as they have better predictable anticoagulation activity. DOAC monitoring, including laboratory monitoring and a complete medication review, should generally be conducted before initiation of a DOAC, 1–3 months after initiation, and then every 6–12 months afterwards.
233:, and other conditions may have too great a risk of bleeding. Generally, the benefit of anticoagulation is preventing or reducing the progression of a thromboembolic disease. Some indications for anticoagulant therapy that are known to have benefit from therapy include:
319:
There is no evidence to indicate that adding anticoagulant therapy to standard treatment has a benefit for people with cerebral small vessel disease but not dementia, and there is an increased risk of a person with this disease experiencing a bleed with this approach.
1143:, direct or indirect filling which extends below the gingiva, complex filling, flap raising procedure, gingival recontouring and biopsies, the dentist needs to take extra precautions apart from the standard procedure. The recommendations are as follows:
1022:
instruments, blood transfusion bags, and medical and surgical equipment will get clogged up and non-operational. In addition, test tubes used for laboratory blood tests will have chemicals added to stop blood clotting. Besides heparin, most of these chemicals
549:), and they have been shown to be as good or possibly better than the coumarins with less serious side effects. The newer anticoagulants (NOACs/DOACs) are more expensive than the traditional ones and should be used in caring for patients with kidney problems.
500:
as a complementary treatment because there are clinical benefits to continuing to walk and remaining mobile while using anticoagulants in this way. Bed rest while using anticoagulants can harm patients in circumstances in which it is not medically necessary.
307:
The decision to begin therapeutic anticoagulation often involves the use of multiple bleeding risk predictable outcome tools as non-invasive pre-test stratifications due to the potential for bleeding while on blood thinning agents. Among these tools are
1126:
medications may undergo dental treatments which are unlikely to cause bleeding, such as local anesthesia injection, basic gum charting, removal of plaque, calculus and stain above the gum level, direct or indirect fillings which are above the gingiva,
6137:
Makris M, Greaves M, Phillips WS, Kitchen S, Rosendaal FR, Preston EF (March 1997). "Emergency oral anticoagulant reversal: the relative efficacy of infusions of fresh frozen plasma and clotting factor concentrate on correction of the coagulopathy".
5675:
Manfredi M, Dave B, Percudani D, Christoforou J, Karasneh J, Diz Dios P, et al. (June 2019). "World workshop on oral medicine VII: Direct anticoagulant agents management for invasive oral procedures: A systematic review and meta-analysis".
6300:
Ryn Jv, Stangier J, Haertter S, Liesenfeld KH, Wienen W, Feuring M, et al. (2010). "Dabigatran etexilate – a novel, reversible, oral direct thrombin inhibitor: Interpretation of coagulation assays and reversal of anticoagulant activity".
971:, and prothrombin complex concentrate (PCC) have been utilized with proven efficacy. Specifically with warfarin, four-factor PCC (4F-PCC) has been shown to have superior safety and mortality benefits compared to FPP in lowering INR levels.
3915:
Yun YP, Do JH, Ko SR, Ryu SY, Kim JH, Song HC, et al. (October 2001). "Effects of Korean red ginseng and its mixed prescription on the high molecular weight dextran-induced blood stasis in rats and human platelet aggregation".
2324:
Poli D, Antonucci E, Pengo V, Migliaccio L, Testa S, Lodigiani C, et al. (September 2018). "Mechanical prosthetic heart valves: Quality of anticoagulation and thromboembolic risk. The observational multicenter PLECTRUM study".
6604:
Marlu R, Hodaj E, Paris A, Albaladejo P, Crackowski J, Pernod G (2012). "Effect of non-specific reversal agents on anticoagulant activity of dabigatran and rivaroxaban: A randomised crossover ex vivo study in healthy volunteers".
6189:
Chai-Adisaksopha C, Hillis C, Siegal DM, Movilla R, Heddle N, Iorio A, et al. (September 2016). "Prothrombin complex concentrates versus fresh frozen plasma for warfarin reversal A systematic review and meta-analysis".
1138:
For a patient who needs to undergo dental treatments which are more likely to cause bleeding, such as simple tooth extractions (1-3 teeth with small wound size), drainage of swelling inside the mouth, periodontal charting,
3751:
Warkentin TE, Greinacher A, Koster A, Lincoff AM (June 2008). "Treatment and prevention of heparin-induced thrombocytopenia: American
College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)".
1506:"Comparison of the Novel Oral Anticoagulants Apixaban, Dabigatran, Edoxaban, and Rivaroxaban in the Initial and Long-Term Treatment and Prevention of Venous Thromboembolism: Systematic Review and Network Meta-Analysis"
5098:
Brizzee L, Stone A, Palmer MC. False lithium toxicity secondary to lithium heparin test tube: A case report and review. Ment Health Clin. 2020 May 7;10(3):90-94. doi: 10.9740/mhc.2020.05.090. PMID: 32420006; PMCID:
4195:
Dentali F, Crowther M, Galli M, Pomero F, Garcia D, Clark N, et al. (2016-05-27). "Effect of
Vitamin K Intake on the Stability of Treatment with Vitamin K Antagonists: A Systematic Review of the Literature".
3879:
Rui TQ, Zhang L, Qiao HZ, Huang P, Qian S, Li JS, et al. (January 2016). "Preparation and
Physicochemical and Pharmacokinetic Characterization of Ginkgo Lactone Nanosuspensions for Antiplatelet Aggregation".
1089:
test would be recommended to confirm the overdose so that the dosage can be adjusted to an acceptable standard. The INR test measures the time it takes for a clot to form in a blood sample relative to a standard.
5109:"Human medicines European public assessment report (EPAR): Pradaxa, dabigatran etexilate, Arthroplasty, Replacement,Venous Thromboembolism, Date of authorisation: 17/03/2008, Revision: 29, Status: Authorised".
638:. There are three major categories of heparin: unfractionated heparin (UFH), low molecular weight heparin (LMWH), and ultra-low-molecular weight heparin (ULMWH). Unfractionated heparin is usually derived from
5848:
van
Diermen DE, van der Waal I, Hoogstraten J (December 2013). "Management recommendations for invasive dental treatment in patients using oral antithrombotic medication, including novel oral anticoagulants".
1093:
An INR value of 1 indicates a level of coagulation equivalent to that of an average patient not taking warfarin, and values greater than 1 indicate a longer clotting time and, thus, a longer bleeding time.
571:(Coumadin), was found to be the anticoagulant most prescribed in a large multispecialty practice. The anticoagulant effect takes at least 48 to 72 hours to develop. Where an immediate effect is required,
2001:"The hemorrhage risk of prophylactic external ventricular drain insertion in aneurysmal subarachnoid hemorrhage patients requiring endovascular aneurysm treatment: a systematic review and meta-analysis"
2099:"Efficacy and Harms of Direct Oral Anticoagulants in the Elderly for Stroke Prevention in Atrial Fibrillation and Secondary Prevention of Venous Thromboembolism: Systematic Review and Meta-Analysis"
344:
immune-mediated HIT is believed to be caused by heparin-dependent immunoglobulin antibodies binding to platelet factor 4/heparin complexes on platelets, leading to widespread platelet activation.
316:. The risk of bleeding using the risk assessment tools above must then be weighed against thrombotic risk to formally determine the patient's overall benefit in starting anticoagulation therapy.
685:(LMWH) is produced through a controlled depolymerization of unfractionated heparin. LMWH exhibits a higher anti-Xa/anti-IIa activity ratio and is useful as it does not require monitoring of the
4441:
Aissaoui N, Martins E, Mouly S, Weber S, Meune C (September 2009). "A meta-analysis of bed rest versus early ambulation in the management of pulmonary embolism, deep vein thrombosis, or both".
2038:
Banerjee K, Poddar K, Mick S, White J, Krishnaswamy A, Johnston D, et al. (November 2017). "Meta-Analysis of
Usefulness of Anticoagulation After Transcatheter Aortic Valve Implantation".
1082:
An overdose of anticoagulants usually occurs in people who have heart problems and need to take anticoagulants in the long term to reduce the risk of stroke from their high blood pressure.
509:
Several anticoagulants are available. Warfarin, other coumarins, and heparins have long been used. Since the 2000s, several agents have been introduced that are collectively referred to as
5571:
6019:
5719:
Bensi C, Belli S, Paradiso D, Lomurno G (July 2018). "Postoperative bleeding risk of direct oral anticoagulants after oral surgery procedures: a systematic review and meta-analysis".
5523:"RUBY-1: a randomized, double-blind, placebo-controlled trial of the safety and tolerability of the novel oral factor Xa inhibitor darexaban (YM150) following acute coronary syndrome"
2197:
Kearon C, Akl EA, Ornelas J, Blaivas A, Jimenez D, Bounameaux H, et al. (February 2016). "Antithrombotic
Therapy for VTE Disease: CHEST Guideline and Expert Panel Report".
489:
interferes with some anticoagulant drugs, increasing the time it takes for them to be metabolized out of the body, and should be eaten with caution when on anticoagulant drugs.
5998:
336:
Nonhemorrhagic adverse events are less common than hemorrhagic adverse events but should still be monitored closely. Nonhemorrhagic adverse events of warfarin include skin
1147:
if the patient has another medical condition or is taking other medication that may increase bleeding risk, consult the patient's general medical practitioner or specialist
3210:"Oral anticoagulant therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines"
890:
The FDA approves
Antithrombin as an anticoagulant for preventing clots before, during, or after surgery or birthing in patients with hereditary antithrombin deficiency.
6709:
Norman M, Jones I (May 2014). "The shift from fluoride/oxalate to acid citrate/fluoride blood collection tubes for glucose testing — The impact upon patient results".
1135:. For all these procedures, it is recommended that the dentist treat the patient following the normal standard procedure and taking care to avoid any bleeding.
5392:
704:
is a synthetic sugar composed of the five sugars (pentasaccharides) in heparin that bind to antithrombin. It is a smaller molecule than low molecular-weight heparin.
6744:
2582:
Raschi E, Bianchin M, De Ponti R, De Ponti F, Ageno W (June 2017). "Emerging therapeutic uses of direct-acting oral anticoagulants: An evidence-based perspective".
1568:"Effectiveness and Safety of Non-vitamin K Antagonist Oral Anticoagulants for Atrial Fibrillation and Venous Thromboembolism: A Systematic Review and Meta-analyses"
5935:
5249:
1058:
has a mechanism similar to that of citrate. It is the anticoagulant used in fluoride/oxalate tubes to determine glucose and lactate levels. The fluoride inhibits
1150:
if the patient is on a short course of anticoagulant or antiplatelet therapy, delay the non-urgent, invasive procedure until the medication has been discontinued
4715:
Pol D, Curtis C, Ramkumar S, Bittinger L (April 2019). "NOACs Now
Mainstream for the Use of Anticoagulation in Non-Valvular Atrial Fibrillation in Australia".
4018:
Kurnik D, Lubetsky A, Loebstein R, Almog S, Halkin H (November 2003). "Multivitamin
Supplements May Affect Warfarin Anticoagulation in Susceptible Patients".
8764:
7844:
4869:
751:
for most DOACs, unlike for warfarin; nonetheless, the short half-lives of DOACs will allow their effects to recede swiftly. A reversal agent for dabigatran,
66:
3327:
Broekmans AW, Bertina RM, Loeliger EA, Hofmann V, Klingemann HG (June 1983). "Protein C and the development of skin necrosis during anticoagulant therapy".
1163:
if travel time to emergency care is a concern, place particular emphasis at the time of the initial treatment on the use of measures to avoid complications
1006:
during the incubation period. It is the standard measure used in the United States and is so named because it was adopted as a standard at a conference in
846:(FDA) in September 2004 and was pulled from the market entirely in February 2006 after reports of severe liver damage and heart attacks. In November 2010,
758:
DOACs are significantly more expensive than warfarin, but the patients on DOACs may experience reduced lab costs as they do not need to monitor their INR.
2542:
Thomas I, EncisoSilva J, Schlueter M, Greenberg B (2016), Bauersachs J, Butler J, Sandner P (eds.), "Anticoagulation Therapy and NOACs in Heart Failure",
1072:
bleeding complications following invasive dental procedures. Therefore, certain guidelines for the dental care of patients taking these drugs are needed.
3292:
Weinberg AC, Lieskovsky G, McGehee WG, Skinner DG (August 1983). "Warfarin necrosis of the skin and subcutaneous tissue of the male external genitalia".
3257:
Verhagen H (2009-04-24). "Local haemorrhage and necrosis of the skin and underlying tissues, during anti-coagulant therapy with dicumarol or dicumacyl".
5003:"Preparation, separation, and conformational analysis of differentially sulfated heparin octasaccharide isomers using ion mobility mass spectrometry"
784:
work by inhibiting factor Xa directly (unlike heparins and fondaparinux, which work via antithrombin activation). Also included in this category are
7812:
867:
clinical prospective studies on DOACs are required to investigate the bleeding risk and hemostasis associated with surgical and dental procedures.
862:
As in any invasive procedure, patients on anticoagulation therapy have an increased risk for bleeding, and caution should be used along with local
6549:"Reversal of Rivaroxaban and Dabigatran by Prothrombin Complex Concentrate: A Randomized, Placebo-Controlled, Crossover Study in Healthy Subjects"
2714:"The HAS-BLED Score for Predicting Major Bleeding Risk in Anticoagulated Patients With Atrial Fibrillation: A Systematic Review and Meta-analysis"
8821:
5575:
5423:"Real-World Adherence and Persistence to Direct Oral Anticoagulants in Patients With Atrial Fibrillation: A Systematic Review and Meta-Analysis"
4357:
Koehl JL, Hayes BD, Al-Samkari H, Rosovsky R (2020-01-23). "A comprehensive evaluation of apixaban in the treatment of venous thromboembolism".
1153:
plan treatment for early in the day and week, where possible, to allow time for the management of prolonged bleeding or re-bleeding if it occurs
4664:
Diener HC, Ntaios G, O'Donnell M, Easton JD (2018-09-22). "Non-vitamin-K oral anticoagulants (NOACs) for the prevention of secondary stroke".
3419:
Talmadge DB, Spyropoulos AC (May 2003). "Purple toes syndrome associated with warfarin therapy in a patient with antiphospholipid syndrome".
3096:"Influence of Renal Function on the Pharmacokinetics, Pharmacodynamics, Efficacy, and Safety of Non-Vitamin K Antagonist Oral Anticoagulants"
1199:
There is general agreement that in most cases, treatment regimens with older anticoagulants (e.g., warfarin) and antiplatelet agents (e.g.,
3596:
Pettifor JM, Benson R (March 1975). "Congenital malformations associated with the administration of oral anticoagulants during pregnancy".
797:
7834:
7565:
6968:
6963:
1195:
follow the specific recommendations and advice given for the management of patients taking different anticoagulants or antiplatelet drugs
793:
1910:
Djulbegovic M, Lee AI (September 2018). "An Update on the "Novel" and Direct Oral Anticoagulants, and Long-Term Anticoagulant Therapy".
8615:
1616:
8575:
7664:
6902:
5886:"Post-operative Bleeding Risk in Dental Surgery for Patients on Oral Anticoagulant Therapy: A Meta-analysis of Observational Studies"
1215:, and/or aspirin) should not be altered before dental procedures. The risks of stopping or reducing these medication regimens (i.e.,
5653:
333:
mortality, recurrence of blood clots in blood vessels, or major or minor bleeding. However, this finding comes only from one study.
6994:
1719:
6874:
3668:"Risk of osteoporotic fracture in elderly patients taking warfarin: results from the National Registry of Atrial Fibrillation 2"
6880:
5973:
2761:
Kwan J, Hafdi M, Chiang LL, Myint PK, Wong LS, Quinn TJ (2022-07-13). Cochrane Dementia and Cognitive Improvement Group (ed.).
2763:"Antithrombotic therapy to prevent cognitive decline in people with small vessel disease on neuroimaging but without dementia"
8188:
7778:
6693:
4411:
2559:
4415:
2998:"Major hemorrhage and tolerability of warfarin in the first year of therapy among elderly patients with atrial fibrillation"
8475:
8468:
4891:
Linhardt RJ (June 2003). "2003 Claude S. Hudson Award address in carbohydrate chemistry. Heparin: structure and activity".
5400:
5052:"Antithrombin III for critically ill patients: a systematic review with meta-analysis and trial sequential analysis"
1171:
6045:
Tornkvist M, Smith JG, Labaf A (February 2018). "Current evidence of oral anticoagulant reversal: A systematic review".
5946:
3789:"Systematic review of fondaparinux for heparin-induced thrombocytopenia: When there are no randomized controlled trials"
723:
The direct oral anticoagulants (DOACs) were introduced in and after 2008. There are five DOACs currently on the market:
8218:
8081:
6745:"Management of Dental Patients Taking Anticoagulants or Antiplatelet Drugs – New guidance from SDCEP | Scottish Dental"
5813:
Kosyfaki P, Att W, Strub JR (August 2011). "The dental patient on oral anticoagulant medication: a literature review".
5256:
1239:
A substantial number of compounds are being investigated for use as anticoagulants. The most promising ones act on the
1156:
perform the procedure as traumatically as possible, use appropriate local measures and only discharge the patient once
2281:
Skelley JW, White CW, Thomason AR (January 2017). "The use of direct oral anticoagulants in inherited thrombophilia".
7842:
7149:
5764:"Managing patients taking novel oral anticoagulants (NOAs) in dentistry: a discussion paper on clinical implications"
4120:
Lippi G, Mattiuzzi C, Franchini M (April 2016). "Vegetables intake and venous thromboembolism: a systematic review".
7795:
6945:
3150:"Oral anticoagulation in people with cancer who have no therapeutic or prophylactic indication for anticoagulation"
2507:
Lander H, Zammert M, FitzGerald D (September 2016). "Anticoagulation management during cross-clamping and bypass".
1665:
1329:
743:. They were also previously referred to as "new/novel" and "non-vitamin K antagonist" oral anticoagulants (NOACs).
8371:
7827:
7759:
7167:
7140:
5631:
1267:
1251:); it is anticipated that this may provide agents that prevent thrombosis without conferring a risk of bleeding.
1034:
17:
3631:
Hall JG, Pauli RM, Wilson KM (January 1980). "Maternal and fetal sequelae of anticoagulation during pregnancy".
2691:
7551:
7094:
1956:
Parks AL, Fang MC (July 2017). "Scoring Systems for Estimating the Risk of Anticoagulant-Associated Bleeding".
7525:
3953:"A systematic review of the pharmacokinetic and pharmacodynamic interactions of herbal medicine with warfarin"
1567:
883:
that can be purified from human plasma or produced recombinantly (for example, Atryn, produced in the milk of
6895:
646:
III (AT), causing a conformational change that results in its activation. The activated AT then inactivates
8070:
7852:
7378:
6027:
5202:"The Reversal of Bleeding Caused by New Oral Anticoagulants (NOACs): A Systematic Review and Meta-Analysis"
4613:
Verdecchia P, Angeli F, Aita A, Bartolini C, Reboldi G (April 2016). "Why switch from warfarin to NOACs?".
4069:
Harder S, Thürmann P (June 1996). "Clinically Important Drug Interactions with Anticoagulants: An Update".
843:
682:
5150:"Laboratory testing in patients treated with direct oral anticoagulants: a practical guide for clinicians"
50:
8681:
7469:
7189:
1277:
3462:
Raj K, Collins B, Rangarajan S (September 2001). "Purple toe syndrome following anticoagulant therapy".
1504:
Cohen AT, Hamilton M, Mitchell SA, Phatak H, Liu X, Bird A, et al. (2015-12-30). ten Cate H (ed.).
8331:
7820:
5200:
Udayachalerm S, Rattanasiri S, Angkananard T, Attia J, Sansanayudh N, Thakkinstian A (September 2018).
1611:"The role of ethylenediamine tetraacetic acid (EDTA) as in vitro anticoagulant for diagnostic purposes"
1062:, which can throw off blood sugar measurements. Citrate/fluoride/EDTA tubes work better in this regard.
6243:"Dabigatran etixilate and traumatic brain injury: Evolving anticoagulants require evolving care plans"
7517:
5936:"Management of Dental Patients Taking Anticoagulants or Antiplatelet Drugs: Dental Clinical Guidance"
1342:
1240:
815:
809:
3836:
Wittkowsky AK (September 2001). "Drug interactions update: drugs, herbs, and oral anticoagulation".
6888:
1330:"Chemical and mechanical alternatives to leech therapy: a systematic review and critical appraisal"
1140:
899:
880:
83:
8858:
8386:
8064:
7915:
7783:
6401:
Connolly SJ, Milling TJ, Eikelboom JW, Gibson CM, Curnutte JT, Gold A, et al. (2016-09-22).
1885:
1305:
968:
460:. Multivitamins that do not interact with clotting are available for patients on anticoagulants.
247:
6910:
6490:
Ansell JE, Bakhru SH, Laulicht BE, Steiner SS, Grosso MA, Brown K, et al. (February 2017).
5148:
Douxfils J, Ageno W, Samama CM, Lessire S, Ten Cate H, Verhamme P, et al. (February 2018).
4314:
Di Nisio M, van Es N, Büller HR (December 2016). "Deep vein thrombosis and pulmonary embolism".
2667:
2625:
1610:
181:
are used in hospitals. Some anticoagulants are used in medical equipment, such as sample tubes,
8868:
8423:
8178:
7132:
7056:
5661:
4271:
Sullivan DM, Ford MA, Boyden TW (1998-08-01). "Grapefruit juice and the response to warfarin".
2000:
1037:(EDTA) strongly and irreversibly chelates (binds) calcium ions, preventing blood from clotting.
588:
301:
186:
5478:
Lekura J, Kalus JS (August 2018). "Overview of betrixaban and its role in clinical practice".
8108:
8044:
7889:
7660:
4521:
Di Minno A, Frigerio B, Spadarella G, Ravani A, Sansaro D, Amato M, et al. (July 2017).
3148:
Kahale LA, Hakoum MB, Tsolakian IG, Matar CF, Barba M, Yosuico VE, et al. (2017-12-29).
1573:
1224:
1049:
999:
940:
277:
2232:
Kapil N, Datta YH, Alakbarova N, Bershad E, Selim M, Liebeskind DS, et al. (May 2017).
8863:
8183:
8163:
8032:
7722:
7301:
7256:
6492:"Single-dose ciraparantag safely and completely reverses anticoagulant effects of edoxaban"
3964:
1519:
1128:
847:
576:
558:
493:
252:
6814:
Weitz JI, Strony J, Ageno W, Gailani D, Hylek EM, Lassen MR, et al. (November 2021).
6352:
Siegal DM, Curnutte JT, Connolly SJ, Lu G, Conley PB, Wiens BL, et al. (2015-12-17).
8:
8792:
8528:
8314:
8093:
7920:
7112:
6685:
6656:
5590:
4931:
Onishi A, St Ange K, Dordick JS, Linhardt RJ (June 2016). "Heparin and anticoagulation".
4870:"Prescribing Patterns of Novel Anticoagulants Within a Statewide Multispecialty Practice"
2148:"Antithrombotic therapy in patients with atrial fibrillation and coronary artery disease"
884:
851:
767:
584:
237:
174:
162:
150:
3968:
1678:
1523:
8826:
8691:
8550:
8004:
7403:
6853:
6840:
6815:
6796:
6638:
6586:
6524:
6491:
6435:
6402:
6334:
6277:
6242:
6223:
6171:
6114:
6081:
5912:
5885:
5790:
5763:
5744:
5701:
5547:
5522:
5503:
5460:
5369:
5336:
5309:
5284:
5226:
5201:
5179:
5130:
5076:
5051:
5027:
5002:
4845:
4812:
4784:
4759:
4740:
4697:
4646:
4590:
4573:
4496:
4471:
4390:
4339:
4229:
4153:
4102:
4051:
3995:
3952:
3861:
3813:
3788:
3573:
3548:
3487:
3444:
3396:
3371:
3352:
3270:
3234:
3209:
3182:
3149:
3125:
3071:
3046:
3027:
2937:
2912:
2885:
2860:
2836:
2811:
2787:
2762:
2738:
2713:
2607:
2489:
2399:
2350:
2306:
2263:
2174:
2147:
2123:
2098:
1981:
1935:
1856:
1831:
1741:
1714:
1687:
1660:
1641:
1565:
Almutairi AR, Zhou L, Gellad WF, Lee JK, Slack MK, Martin JR, et al. (July 2017).
1542:
1505:
1481:
1446:
1422:
1409:
1389:
1370:
1354:
1108:
Assessment of the likely risk of bleeding associated with the required dental procedure
1045:
1019:
1007:
952:
580:
437:
282:
146:, which help keep the bite area unclotted long enough for the animal to obtain blood.
119:
6722:
6565:
6548:
6547:
Eerenberg ES, Kamphuisen PW, Sijpkens MK, Meijers JC, Buller HR, Levi M (2011-10-04).
5521:
Steg PG, Mehta SR, Jukema JW, Lip GY, Gibson CM, Kovar F, et al. (October 2011).
4327:
3929:
3728:
3711:
3609:
3507:"Vitamin K in the treatment and prevention of osteoporosis and arterial calcification"
3305:
3014:
2997:
2974:
2114:
89:
8832:
8787:
8570:
8560:
8463:
8293:
8249:
8233:
8037:
8027:
7970:
7960:
7647:
7418:
7408:
7398:
7393:
7388:
7363:
6936:
6923:
6915:
6857:
6845:
6800:
6788:
6726:
6689:
6630:
6622:
6578:
6570:
6529:
6511:
6467:
6440:
6422:
6383:
6375:
6326:
6318:
6282:
6264:
6215:
6207:
6163:
6155:
6119:
6101:
6062:
5917:
5866:
5830:
5826:
5795:
5736:
5705:
5693:
5613:
5552:
5495:
5464:
5452:
5444:
5374:
5356:
5341:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
5314:
5231:
5171:
5149:
5134:
5122:
5081:
5032:
4983:
4948:
4908:
4850:
4832:
4789:
4732:
4689:
4681:
4638:
4630:
4595:
4554:
4501:
4458:
4394:
4382:
4374:
4331:
4296:
4288:
4221:
4213:
4145:
4137:
4094:
4086:
4082:
4043:
4035:
4000:
3982:
3933:
3897:
3853:
3818:
3769:
3733:
3689:
3648:
3644:
3613:
3578:
3529:
3479:
3475:
3436:
3401:
3344:
3309:
3274:
3239:
3187:
3169:
3117:
3076:
3019:
2978:
2942:
2890:
2841:
2792:
2743:
2599:
2565:
2555:
2524:
2481:
2440:
2391:
2342:
2298:
2255:
2214:
2179:
2128:
2055:
2020:
1973:
1927:
1861:
1806:
1773:
1746:
1732:
1692:
1633:
1590:
1547:
1486:
1468:
1427:
1374:
1362:
1216:
1123:
974:
Although specific antidotes and reversal agents for DOACs are not as widely studied,
635:
413:
230:
205:
182:
170:
6642:
6338:
6175:
5980:
5507:
5439:
5422:
5300:
5183:
4744:
4701:
4650:
4343:
4233:
4157:
4106:
4055:
3865:
3491:
3448:
3370:
Grimaudo V, Gueissaz F, Hauert J, Sarraj A, Kruithof EK, Bachmann F (January 1989).
3356:
3208:
Ageno W, Gallus AS, Wittkowsky A, Crowther M, Hylek EM, Palareti G (February 2012).
3129:
2928:
2611:
2354:
2310:
2267:
1939:
1880:
1645:
1586:
1192:
provide the patient with written post-treatment advice and emergency contact details
293:
Cardiopulmonary bypass (or any other surgeries requiring temporary aortic occlusion)
8797:
8620:
8545:
8533:
8458:
8324:
8203:
7992:
7621:
7452:
7413:
7383:
6835:
6827:
6778:
6718:
6614:
6560:
6519:
6503:
6430:
6414:
6365:
6310:
6272:
6254:
6227:
6199:
6147:
6109:
6093:
6058:
6054:
6020:"Antithrombin (Recombinant) US Package Insert ATryn for Injection February 3, 2009"
5907:
5897:
5858:
5822:
5785:
5775:
5748:
5728:
5685:
5605:
5542:
5534:
5487:
5434:
5364:
5348:
5304:
5296:
5221:
5213:
5161:
5114:
5071:
5063:
5022:
5014:
4975:
4940:
4900:
4840:
4824:
4779:
4771:
4724:
4673:
4622:
4585:
4544:
4534:
4491:
4483:
4450:
4366:
4323:
4280:
4205:
4129:
4078:
4027:
3990:
3972:
3925:
3889:
3845:
3808:
3800:
3761:
3723:
3679:
3640:
3605:
3568:
3560:
3521:
3471:
3428:
3391:
3383:
3336:
3301:
3266:
3229:
3221:
3177:
3165:
3161:
3107:
3066:
3058:
3031:
3009:
2970:
2932:
2924:
2880:
2872:
2831:
2823:
2782:
2778:
2774:
2733:
2725:
2646:
2591:
2547:
2516:
2493:
2471:
2430:
2381:
2334:
2290:
2245:
2206:
2169:
2159:
2118:
2110:
2047:
2016:
2012:
1985:
1965:
1919:
1851:
1843:
1736:
1728:
1710:
1682:
1674:
1625:
1582:
1537:
1527:
1476:
1464:
1460:
1451:
1417:
1401:
1346:
1086:
712:
8264:
6590:
4966:
Casu B, Naggi A, Torri G (February 2015). "Re-visiting the structure of heparin".
4677:
4370:
3506:
3047:"Nonvitamin K antagonist oral anticoagulant use in patients with renal impairment"
2403:
2051:
1847:
8837:
8782:
8651:
8646:
8485:
8418:
8413:
8299:
8245:
8086:
7977:
7930:
7425:
4979:
4454:
4424:
4420:
4171:
4133:
3977:
3112:
3095:
2827:
2338:
1532:
938:
is an anticoagulant protease from the salivary glands of the giant Amazon leech,
353:
268:
264:
190:
166:
5337:"Direct Oral Anticoagulant Use: A Practical Guide to Common Clinical Challenges"
3432:
2876:
2210:
1297:
1258:
is in Phase II clinical trials for the prevention of an embolism after surgery.
8816:
8716:
8711:
8565:
8555:
8505:
8490:
8480:
8381:
8376:
8366:
8304:
8276:
8228:
8223:
7955:
7910:
7906:
7789:
7316:
7002:
6911:
6459:
5862:
5732:
5538:
5255:. Scottish Dental Clinical Effectiveness Programme. August 2015. Archived from
4539:
4523:"Old and new oral anticoagulants: Food, herbal medicines and drug interactions"
4522:
3893:
3684:
3667:
2595:
2435:
2418:
1798:
1765:
979:
405:
6403:"Andexanet Alfa for Acute Major Bleeding Associated with Factor Xa Inhibitors"
5780:
5067:
4828:
4775:
4728:
4626:
4284:
3849:
2520:
2294:
1923:
1405:
630:
Heparin is the most widely used intravenous clinical anticoagulant worldwide.
8852:
8748:
8721:
8580:
8398:
8309:
8289:
8285:
8148:
8076:
7880:
7716:
7306:
7291:
7286:
6626:
6574:
6515:
6426:
6379:
6322:
6268:
6211:
6159:
6105:
5902:
5448:
5360:
5217:
5126:
4836:
4685:
4634:
4378:
4292:
4217:
4141:
4090:
4039:
3986:
3387:
3173:
3062:
2250:
2233:
2073:
1472:
1413:
1358:
596:
592:
575:
is given concomitantly. These anticoagulants are used to treat patients with
472:
131:
6259:
6097:
5996:
5352:
4487:
3666:
Gage BF, Birman-Deych E, Radford MJ, Nilasena DS, Binder EF (January 2006).
2234:"Antiplatelet and Anticoagulant Therapies for Prevention of Ischemic Stroke"
8706:
8625:
8361:
8319:
8153:
8143:
8059:
8054:
7736:
7706:
7684:
7679:
7652:
7601:
7580:
7430:
7369:
7325:
7202:
7145:
7084:
7079:
7060:
6958:
6927:
6849:
6792:
6730:
6634:
6582:
6533:
6471:
6444:
6387:
6330:
6286:
6219:
6151:
6123:
6066:
5921:
5870:
5834:
5799:
5740:
5697:
5617:
5556:
5499:
5456:
5378:
5318:
5250:"Management of Dental Patients Taking Anticoagulants or Antiplatelet Drugs"
5235:
5175:
5085:
5036:
4987:
4952:
4912:
4854:
4813:"Orale Antikoagulation bei chronischer Nierenerkrankung und Vorhofflimmern"
4793:
4736:
4693:
4642:
4599:
4558:
4505:
4462:
4386:
4335:
4225:
4209:
4149:
4047:
4004:
3937:
3901:
3857:
3822:
3773:
3737:
3693:
3582:
3533:
3483:
3440:
3340:
3278:
3243:
3191:
3121:
3080:
3023:
2982:
2946:
2894:
2845:
2796:
2747:
2603:
2569:
2528:
2485:
2444:
2386:
2369:
2346:
2302:
2259:
2218:
2183:
2132:
2059:
2024:
1977:
1969:
1931:
1865:
1810:
1777:
1750:
1696:
1637:
1594:
1551:
1490:
1431:
1366:
1350:
1272:
1132:
975:
839:
752:
701:
667:
643:
476:
361:
313:
241:
209:
71:
6831:
6418:
6370:
6353:
6167:
4300:
4098:
3765:
3652:
3617:
3405:
3372:"Necrosis of skin induced by coumarin in a patient deficient in protein S"
3348:
3313:
3225:
2395:
2164:
1629:
674:
brand blood collecting tubes containing heparin usually have a green cap.
8590:
8500:
8240:
8193:
8138:
8021:
7987:
7606:
7534:
7503:
7435:
7336:
7330:
7320:
7223:
7017:
7007:
6618:
6507:
6314:
6203:
5609:
5118:
5050:
Allingstrup M, Wetterslev J, Ravn FB, Møller AM, Afshari A (April 2016).
4572:
Almarshad F, Alaklabi A, Bakhsh E, Pathan A, Almegren M (December 2018).
4172:"Avocado: Health Benefits, Uses, Side Effects, Dosage & Interactions"
3564:
2551:
2476:
2459:
1204:
1200:
1167:
1003:
903:
827:
773:
728:
707:
689:
619:
611:
604:
534:
496:. People using anticoagulants to treat this condition should avoid using
425:
357:
198:
178:
135:
123:
8768:
8739:
8697:
8666:
8661:
8600:
8595:
8585:
8523:
8509:
8449:
8404:
8352:
8272:
8268:
8209:
8169:
8124:
8120:
8010:
7946:
7896:
7861:
7857:
7711:
7628:
7611:
7596:
7575:
7560:
7555:
7498:
7483:
7457:
7447:
7442:
7296:
7265:
7197:
7177:
7155:
7044:
7028:
7024:
6973:
5491:
5285:"Role of the anticoagulant monitoring service in 2018: beyond warfarin"
5199:
4549:
3804:
3525:
1400:(2). The Korean Society for Parasitology and Tropical Medicine: 183–8.
1244:
1212:
1183:
1157:
1059:
1002:
activity. It is the amount of inhibitor that will inactivate half of a
929:
910:
863:
835:
831:
785:
740:
724:
671:
615:
600:
542:
530:
486:
445:
429:
287:
158:
41:
6783:
6766:
5689:
5639:
5421:
Ozaki AF, Choi AS, Le QT, Ko DT, Han JK, Park SS, et al. (2020).
5166:
5018:
4904:
4247:
4031:
3203:
3201:
2906:
2904:
2729:
2546:, vol. 243, Springer International Publishing, pp. 515–535,
1390:"Detection of heparin in the salivary gland and midgut of Aedes togoi"
1131:, taking impression for denture or crown and fitting or adjustment of
463:
However, some foods and supplements encourage clotting. These include
452:
bark. Many herbal supplements have blood-thinning properties, such as
102:
8676:
8656:
8630:
8605:
8540:
8518:
8346:
8259:
8133:
7699:
7694:
7674:
7669:
7616:
7570:
7544:
7539:
7488:
7346:
7269:
7233:
7207:
7172:
7160:
7122:
7117:
7107:
7069:
7039:
7034:
7012:
6978:
6953:
4410:
2861:"Reversal of warfarin-induced hemorrhage in the emergency department"
2097:
Sharma M, Cornelius VR, Patel JP, Davies JG, Molokhia M (July 2015).
1327:
Azzopardi EA, Whitaker IS, Rozen WM, Naderi N, Kon M (October 2011).
1255:
1248:
1208:
1179:
1024:
947:
823:
789:
647:
401:
377:
3549:"Vitamin K-dependent proteins, warfarin, and vascular calcification"
695:
8777:
8641:
8637:
8610:
8049:
7982:
7901:
7493:
7478:
7311:
7282:
7273:
7261:
7228:
7074:
6188:
3705:
3703:
3198:
2901:
2541:
1510:
1187:
935:
925:
781:
777:
736:
732:
662:
651:
568:
564:
546:
538:
497:
457:
441:
409:
381:
369:
337:
309:
194:
143:
6767:"New Anticoagulants: Moving Beyond the Direct Oral Anticoagulants"
6546:
5847:
5761:
2996:
Hylek EM, Evans-Molina C, Shea C, Henault LE, Regan S (May 2007).
8753:
8671:
8336:
8103:
7925:
7875:
7764:
7754:
7731:
7529:
7358:
7102:
6354:"Andexanet Alfa for the Reversal of Factor Xa Inhibitor Activity"
5762:
Costantinides F, Rizzo R, Pascazio L, Maglione M (January 2016).
5674:
4944:
1175:
1055:
1040:
1027:
819:
666:
to prevent blood or plasma clotting in or on medical devices. In
656:
631:
572:
480:
468:
464:
453:
433:
397:
217:
154:
4520:
3750:
3700:
3291:
2370:"Antiplatelet and anticoagulant use after myocardial infarction"
8435:
8098:
7726:
5049:
4663:
4470:
Anderson CM, Overend TJ, Godwin J, Sealy C, Sunderji A (2009).
3665:
3326:
2913:"Breadth of complications of long-term oral anticoagulant care"
2416:
1220:
642:
intestines and bovine lungs. UFH binds to the enzyme inhibitor
449:
421:
393:
389:
385:
373:
259:
6400:
5997:
Center for Biologics Evaluation and Research (24 April 2019).
5851:
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
4926:
4924:
4922:
2581:
8735:
8445:
7940:
6988:
6299:
5289:
Hematology. American Society of Hematology. Education Program
4868:
Efird LE, Chasler J, Alexander GC, McGuire M (Jun 21, 2016).
4612:
4571:
3207:
2917:
Hematology. American Society of Hematology. Education Program
2417:
Konstantinides SV, Barco S, Lankeit M, Meyer G (March 2016).
1661:"Safe anticoagulation when heart and lungs are "on vacation""
1447:"Anticoagulant treatment for subsegmental pulmonary embolism"
1104:
There are two main parts to the assessment of bleeding risk:
921:
918:
914:
792:(YM150) from Astellas, and, more recently, the discontinued
417:
213:
formation of fibrin and stable aggregated platelet products.
139:
127:
6136:
4930:
4867:
4472:"Ambulation after deep vein thrombosis: a systematic review"
4356:
4017:
3369:
2995:
2460:"Anticoagulation after coronary stenting: a systemic review"
2323:
1326:
1066:
8439:
7633:
6489:
4919:
2231:
2145:
1503:
1388:
Ha YR, Oh SR, Seo ES, Kim BH, Lee DK, Lee SJ (April 2014).
1030:
ions, preventing the coagulation proteins from using them.
818:. Current members of this class include the bivalent drugs
686:
365:
5147:
4757:
4714:
4469:
4194:
3147:
2096:
1715:"Warfarin: almost 60 years old and still causing problems"
1254:
As of November 2021, the direct factor XIa inhibitor
1111:
Assessment of the patient's individual-level bleeding risk
6603:
5718:
4760:"Anticoagulation in atrial fibrillation: NOAC's the word"
4440:
639:
6816:"Milvexian for the Prevention of Venous Thromboembolism"
6351:
5588:
4810:
3951:
Choi S, Oh DS, Jerng UM (2017-08-10). Borrelli F (ed.).
2959:
567:
found in many plants. A prominent member of this class,
6813:
5721:
International Journal of Oral and Maxillofacial Surgery
4119:
2506:
2196:
2037:
1445:
Yoo HH, Nunes-Nogueira VS, Boas, PJ (7 February 2020).
1444:
55:
Coagulation cascade and major classes of anticoagulants
5589:
Di Nisio M, Middeldorp S, Büller HR (September 2005).
3553:
Clinical Journal of the American Society of Nephrology
2639:
2509:
Best Practice & Research. Clinical Anaesthesiology
1564:
1170:, unless contraindicated, for pain relief rather than
677:
7845:
Anatomical Therapeutic Chemical Classification System
5638:. The Thrombophilia Awareness Project. Archived from
4574:"Use of direct oral anticoagulants in daily practice"
4416:"Five Things Physicians and Patients Should Question"
2712:
Zhu W, He W, Guo L, Wang X, Hong K (September 2015).
1829:
1763:
654:, and other coagulation factors. Heparin can be used
5334:
4758:
Werdan K, Braun-Dullaeus R, Presek P (August 2013).
4313:
3461:
3044:
2760:
2367:
2280:
985:
874:
625:
552:
6044:
6040:
6038:
5884:Shi Q, Xu J, Zhang T, Zhang B, Liu H (2017-02-08).
4811:Heine GH, Brandenburg V, Schirmer SH (2018-04-27).
3793:
Research and Practice in Thrombosis and Haemostasis
3418:
2858:
1658:
5968:
5966:
5520:
4270:
3786:
3709:
3045:Turpie AG, Purdham D, Ciaccia A (September 2017).
2146:Moustafa A, Ruzieh M, Eltahawy E, Karim S (2019).
1609:
1607:
1566:
1328:
529:. These agents include direct thrombin inhibitor (
165:anticoagulants (OACs) are taken by many people in
6877:by the Agency for Healthcare Research and Quality
5572:"First Time European Approval for Xarelto in ACS"
3878:
2618:
1830:Harter K, Levine M, Henderson SO (January 2015).
857:
850:was approved by the FDA to prevent thrombosis in
696:Synthetic pentasaccharide inhibitors of factor Xa
8850:
6764:
6035:
5943:Scottish Dental Clinical Effectiveness Programme
5812:
5427:Circulation: Cardiovascular Quality and Outcomes
1951:
1949:
6457:
5963:
5883:
5654:"Exanta™ (ximelagatran) Study report summaries"
5195:
5193:
3787:Linkins LA, Hu G, Warkentin TE (October 2018).
3630:
2859:Zareh M, Davis A, Henderson S (November 2011).
2684:
924:, clots platelet-rich plasma without affecting
788:from Portola Pharmaceuticals, the discontinued
6875:Staying Active and Healthy with Blood Thinners
6014:
6012:
5000:
4965:
4068:
3595:
3051:Therapeutic Advances in Cardiovascular Disease
1909:
1878:
761:
7828:
6896:
5420:
2910:
2423:Journal of the American College of Cardiology
2419:"Management of Pulmonary Embolism: An Update"
2368:Almony GT, Lefkovits J, Topol EJ (May 1996).
1946:
1796:
1764:Patel S, Singh R, Preuss CV, Patel N (2020).
803:
492:Anticoagulants are often used to treat acute
7843:Major chemical drug groups – based upon the
6765:Fredenburgh JC, Weitz JI (12 October 2020).
5582:
5335:Chen A, Stecker E, A Warden B (2020-06-15).
5190:
3829:
3504:
2989:
2711:
2668:"HEMORR₂HAGES Score for Major Bleeding Risk"
1608:Banfi G, Salvagno GL, Lippi G (2007-01-01).
583:(PE) and to prevent emboli in patients with
527:non-vitamin K antagonist oral anticoagulants
193:equipment. One of the first anticoagulants,
6708:
6009:
5477:
4406:
4404:
3950:
1452:The Cochrane Database of Systematic Reviews
563:These oral anticoagulants are derived from
216:Common anticoagulants include warfarin and
7835:
7821:
6903:
6889:
6679:
5569:
5480:American Journal of Health-System Pharmacy
5399:. British Heart Foundation. Archived from
5206:Clinical and Applied Thrombosis/Hemostasis
4273:American Journal of Health-System Pharmacy
3914:
3835:
3710:Baroletti SA, Goldhaber SZ (August 2006).
3514:American Journal of Health-System Pharmacy
3093:
2238:Clinical and Applied Thrombosis/Hemostasis
1872:
1709:
1617:Clinical Chemistry and Laboratory Medicine
1387:
618:are used as mammalicides (particularly as
49:
6839:
6782:
6564:
6523:
6434:
6369:
6276:
6258:
6240:
6113:
5911:
5901:
5789:
5779:
5546:
5438:
5368:
5308:
5225:
5165:
5075:
5026:
4844:
4783:
4589:
4548:
4538:
4495:
3994:
3976:
3812:
3727:
3683:
3572:
3498:
3395:
3233:
3181:
3111:
3070:
3013:
2936:
2884:
2865:The Western Journal of Emergency Medicine
2835:
2816:The Western Journal of Emergency Medicine
2786:
2737:
2475:
2457:
2434:
2385:
2249:
2173:
2163:
2122:
1955:
1855:
1836:The Western Journal of Emergency Medicine
1740:
1686:
1541:
1531:
1480:
1421:
1067:Dental considerations for long-term users
5141:
5001:Seo Y, Andaya A, Leary JA (March 2012).
4890:
4401:
3546:
3256:
2809:
2626:"HAS-BLED Score for Major Bleeding risk"
1832:"Anticoagulation drug therapy: a review"
1720:British Journal of Clinical Pharmacology
1659:Dobrovolskaia MA, McNeil SE (May 2015).
300:In these cases, anticoagulation therapy
4428:, American Physical Therapy Association
3154:Cochrane Database of Systematic Reviews
2812:"Emergency Reversal of Anticoagulation"
2767:Cochrane Database of Systematic Reviews
1881:"Race Is on for the Next Blood Thinner"
14:
8851:
8822:Pharmacological classification systems
8189:Selective estrogen receptor modulators
6079:
5999:"Fractionated Plasma Products - ATryn"
3838:Journal of Thrombosis and Thrombolysis
2283:Journal of Thrombosis and Thrombolysis
1335:Journal of Reconstructive Microsurgery
1122:A patient who is on anticoagulants or
879:The antithrombin protein is used as a
692:parameter and has fewer side effects.
204:Anticoagulants are closely related to
8469:Non-steroidal anti-inflammatory drugs
7816:
6884:
6771:Journal of Thrombosis and Haemostasis
5330:
5328:
5282:
5278:
5276:
5154:Journal of Thrombosis and Haemostasis
4874:American Journal of Pharmacy Benefits
4412:American Physical Therapy Association
4248:"Warfarin Uses, Dosage, Side Effects"
4198:Seminars in Thrombosis and Hemostasis
3143:
3141:
3139:
2911:Ageno W, Donadini M (November 2018).
1958:Seminars in Thrombosis and Hemostasis
842:(Exanta), was denied approval by the
838:. An oral direct thrombin inhibitor,
814:Another type of anticoagulant is the
5574:. Decision Resources. Archived from
5514:
4122:Blood Coagulation & Fibrinolysis
1087:International Normalised Ratio (INR)
356:with blood-thinning effects include
271:) — can lead to deep vein thrombosis
8082:Angiotensin II receptor antagonists
6820:The New England Journal of Medicine
5598:The New England Journal of Medicine
4443:International Journal of Cardiology
2327:International Journal of Cardiology
1998:
1879:Winslow R, Johnson A (2007-12-10).
1679:10.3978/j.issn.2305-5839.2015.02.03
1298:"Overview: Anticoagulant medicines"
898:Many other anticoagulants exist in
678:Low molecular weight heparin (LMWH)
24:
6458:Reed M, Tadi P, Nicolas D (2020),
5385:
5325:
5273:
5242:
4764:Deutsches Ärzteblatt International
4578:American Journal of Blood Research
3882:Journal of Pharmaceutical Sciences
3712:"Heparin-induced thrombocytopenia"
3505:Adams J, Pepping J (August 2005).
3271:10.1111/j.0954-6820.1954.tb01741.x
3136:
3094:Weir MR, Kreutz R (October 2018).
2458:Dong Z, Zheng J (September 2017).
2040:The American Journal of Cardiology
1797:Iqbal AM, Lopez RA, Hai O (2020).
1394:The Korean Journal of Parasitology
961:
323:
25:
8880:
6868:
6723:10.1016/j.clinbiochem.2014.01.011
6682:Handbook of Hematologic Pathology
6566:10.1161/CIRCULATIONAHA.111.029017
4666:Expert Opinion on Pharmacotherapy
3729:10.1161/CIRCULATIONAHA.106.632653
3015:10.1161/CIRCULATIONAHA.106.653048
2115:10.1161/CIRCULATIONAHA.114.013267
2005:Journal of Neurosurgical Sciences
1013:
986:Coagulation inhibitor measurement
875:Antithrombin protein therapeutics
626:Heparin and derivative substances
553:Coumarins (vitamin K antagonists)
8831:
8811:
8810:
7518:Direct thrombin (IIa) inhibitors
6946:Glycoprotein IIb/IIIa inhibitors
6807:
6758:
6737:
6702:
6673:
6649:
6597:
6540:
6483:
6451:
6394:
6345:
6293:
6234:
6182:
6130:
6073:
5990:
5928:
5877:
5841:
5827:10.1111/j.1365-2842.2010.02184.x
5806:
5755:
5712:
5668:
5646:
5624:
4083:10.2165/00003088-199630060-00002
3633:The American Journal of Medicine
3476:10.1046/j.1365-2141.2001.03107.x
1733:10.1111/j.1365-2125.2006.02806.x
1666:Annals of Translational Medicine
479:, and dark leafy greens such as
255:— can lead to pulmonary embolism
8219:Hypothalamic–pituitary hormones
7141:Thromboxane synthase inhibitors
6407:New England Journal of Medicine
6358:New England Journal of Medicine
6247:World Journal of Clinical Cases
5563:
5471:
5440:10.1161/CIRCOUTCOMES.119.005969
5414:
5301:10.1182/asheducation-2018.1.348
5102:
5092:
5043:
4994:
4959:
4884:
4861:
4804:
4751:
4708:
4657:
4615:Internal and Emergency Medicine
4606:
4565:
4514:
4350:
4307:
4264:
4240:
4188:
4164:
4113:
4062:
4011:
3944:
3908:
3872:
3780:
3744:
3659:
3624:
3589:
3540:
3455:
3412:
3363:
3320:
3285:
3250:
3087:
3038:
2953:
2929:10.1182/asheducation-2018.1.432
2852:
2810:Yee J, Kaide CG (August 2019).
2803:
2754:
2705:
2660:
2575:
2535:
2500:
2451:
2410:
2361:
2317:
2274:
2225:
2190:
2139:
2090:
2066:
2031:
1992:
1903:
1823:
1790:
1757:
1587:10.1016/j.clinthera.2017.05.358
1268:Hypercoagulability in pregnancy
1166:advise the patient to take
1035:Ethylenediaminetetraacetic acid
347:
223:
6059:10.1016/j.thromres.2017.12.003
5815:Journal of Oral Rehabilitation
4893:Journal of Medicinal Chemistry
3464:British Journal of Haematology
3166:10.1002/14651858.cd006466.pub6
2779:10.1002/14651858.CD012269.pub2
2017:10.23736/S0390-5616.16.03244-6
1703:
1652:
1601:
1558:
1497:
1465:10.1002/14651858.CD010222.pub4
1438:
1381:
1320:
1290:
858:Relevance to dental treatments
718:
622:) but are not used medically.
304:or growth of dangerous clots.
197:, was initially approved as a
13:
1:
7971:Thrombolytics / fibrinolytics
6086:Journal of Clinical Pathology
5570:Dwyer J, Walsh C (May 2013).
4678:10.1080/14656566.2018.1515913
4371:10.1080/17474086.2020.1711731
4328:10.1016/S0140-6736(16)30514-1
3930:10.1016/S0378-8741(01)00303-8
3672:Archives of Internal Medicine
3610:10.1016/S0022-3476(75)80986-3
3547:Danziger J (September 2008).
3306:10.1016/S0022-5347(17)51147-7
2975:10.1016/S2352-3026(15)00257-4
2052:10.1016/j.amjcard.2017.07.059
1848:10.5811/westjem.2014.12.22933
1283:
1018:If blood is allowed to clot,
153:, anticoagulants are used in
122:that prevents or reduces the
8682:Wakefulness-promoting agents
7379:Low-molecular-weight heparin
7190:Phosphodiesterase inhibitors
7103:Acetylsalicylic acid/Aspirin
6028:Food and Drug Administration
5591:"Direct thrombin inhibitors"
4980:10.1016/j.carres.2014.06.023
4455:10.1016/j.ijcard.2008.06.020
4134:10.1097/MBC.0000000000000427
3978:10.1371/journal.pone.0182794
3918:Journal of Ethnopharmacology
3645:10.1016/0002-9343(80)90181-3
3113:10.1016/j.mayocp.2018.06.018
2828:10.5811/westjem.2018.5.38235
2339:10.1016/j.ijcard.2018.04.042
2152:Avicenna Journal of Medicine
1533:10.1371/journal.pone.0144856
844:Food and Drug Administration
683:Low molecular weight heparin
7:
5658:AstraZeneca Clinical Trials
4817:Deutsches Ärzteblatt Online
4717:Heart, Lung and Circulation
4359:Expert Review of Hematology
3433:10.1592/phco.23.5.674.32200
2877:10.5811/westjem.2011.3.2051
2211:10.1016/j.chest.2015.11.026
1278:Direct factor Xa inhibitors
1261:
1234:
762:Direct factor Xa inhibitors
533:) and factor Xa inhibitor (
312:, ATRIA, HEMORR2HAGES, and
10:
8885:
8332:Intravenous immunoglobulin
6607:Thrombosis and Haemostasis
6496:Thrombosis and Haemostasis
6303:Thrombosis and Haemostasis
6192:Thrombosis and Haemostasis
6140:Thrombosis and Haemostasis
5863:10.1016/j.oooo.2013.07.026
5733:10.1016/j.ijom.2018.03.016
5283:Clark NP (November 2018).
4540:10.1016/j.blre.2017.02.001
3894:10.1016/j.xphs.2015.10.002
3685:10.1001/archinte.166.2.241
3329:Thrombosis and Haemostasis
2596:10.1016/j.phrs.2017.03.026
2436:10.1016/j.jacc.2015.11.061
1799:"Antiplatelet Medications"
807:
804:Direct thrombin inhibitors
796:(TAK-442) from Takeda and
765:
556:
511:direct oral anticoagulants
134:. Some occur naturally in
8806:
8762:
8734:
8690:
8499:
8434:
8397:
8345:
8258:
8202:
8162:
8119:
8003:
7939:
7851:
7773:
7745:
7646:
7589:
7516:
7468:
7357:
7351:(with some II inhibition)
7345:
7255:
7246:
7216:
7188:
7131:
7093:
7055:
6987:
6944:
6935:
6466:, StatPearls Publishing,
5890:Frontiers in Pharmacology
5781:10.1186/s12903-016-0170-7
5068:10.1007/s00134-016-4225-7
4829:10.3238/arztebl.2018.0287
4776:10.3238/arztebl.2013.0523
4729:10.1016/j.hlc.2018.03.010
4627:10.1007/s11739-016-1411-0
4071:Clinical Pharmacokinetics
4020:Annals of Pharmacotherapy
3598:The Journal of Pediatrics
2521:10.1016/j.bpa.2016.07.002
2295:10.1007/s11239-016-1428-2
1924:10.1016/j.ccm.2018.04.010
1912:Clinics in Chest Medicine
1805:. StatPearls Publishing.
1772:. StatPearls Publishing.
1406:10.3347/kjp.2014.52.2.183
1343:Thieme Medical Publishers
1241:contact activation system
906:, or as drug candidates.
830:and the monovalent drugs
816:direct thrombin inhibitor
810:Direct thrombin inhibitor
660:(by injection), and also
634:is a naturally occurring
519:novel oral anticoagulants
101:
96:
82:
77:
65:
60:
48:
39:
34:
8387:Topoisomerase inhibitors
8071:renin–angiotensin system
8065:Calcium channel blockers
6080:Hanley JP (2004-11-01).
5903:10.3389/fphar.2017.00058
5539:10.1093/eurheartj/ehr334
5218:10.1177/1076029618796339
3388:10.1136/bmj.298.6668.233
3259:Acta Medica Scandinavica
3063:10.1177/1753944717714921
2584:Pharmacological Research
2464:British Medical Bulletin
2251:10.1177/1076029616660762
998:) is a measure of blood
900:research and development
893:
504:
6260:10.12998/wjcc.v2.i8.362
6098:10.1136/jcp.2003.008904
5353:10.1161/JAHA.120.017559
5056:Intensive Care Medicine
4933:Frontiers in Bioscience
4488:10.3138/physio.61.3.133
4423:: an initiative of the
4285:10.1093/ajhp/55.15.1581
3850:10.1023/A:1012742628628
3100:Mayo Clinic Proceedings
2963:The Lancet. Haematology
1999:Zhu X (February 2017).
1886:The Wall Street Journal
1099:Assessing bleeding risk
969:recombinant factor VIIa
589:prosthetic heart valves
274:Mechanical heart valves
248:Coronary artery disease
8179:Hormonal contraception
8109:Bile acid sequestrants
7890:Proton-pump inhibitors
7853:gastrointestinal tract
7661:Plasminogen activators
7133:Thromboxane inhibitors
7057:Prostaglandin analogue
6680:Schumacher HR (2000).
6152:10.1055/s-0038-1655992
5527:European Heart Journal
5397:Heart Matters Magazine
5393:"Novel anticoagulants"
5212:(9_suppl): 117S–126S.
4210:10.1055/s-0036-1581105
3760:(6 Suppl): 340S–380S.
3341:10.1055/s-0038-1657378
3294:The Journal of Urology
3220:(2 Suppl): e44S–e88S.
2387:10.1002/clc.4960190506
1970:10.1055/s-0037-1598061
1351:10.1055/s-0031-1284233
1133:orthodontic appliances
1117:Managing bleeding risk
302:prevents the formation
114:, commonly known as a
7723:serine endopeptidases
7257:Vitamin K antagonists
6832:10.1056/NEJMoa2113194
6711:Clinical Biochemistry
6419:10.1056/NEJMoa1607887
6371:10.1056/NEJMoa1510991
5974:"Thrombate III label"
5111:Case Medical Research
4968:Carbohydrate Research
4799:serious side effects.
4414:(15 September 2014),
3766:10.1378/chest.08-0677
3226:10.1378/chest.11-2292
2647:"ATRIA Bleeding Risk"
2165:10.4103/ajm.AJM_73_19
1630:10.1515/CCLM.2007.110
1574:Clinical Therapeutics
1225:myocardial infarction
1050:acid-citrate-dextrose
1000:coagulation inhibitor
978:(for dabigatran) and
941:Haementeria ghilianii
591:. Other examples are
587:(AF), and mechanical
557:Further information:
278:Myocardial infarction
8788:Radiopharmaceuticals
8576:Antiparkinson agents
7470:Direct Xa inhibitors
7302:Ethyl biscoumacetate
7168:Receptor antagonists
6619:10.1160/TH12-03-0179
6508:10.1160/TH16-03-0224
6315:10.1160/TH09-11-0758
6241:Pakraftar S (2014).
6204:10.1160/TH16-04-0266
5636:Ask Dr. Stephan Moll
5610:10.1056/NEJMra044440
5119:10.31525/cmr-1321569
5007:Analytical Chemistry
4476:Physiotherapy Canada
4322:(10063): 3060–3073.
3565:10.2215/CJN.00770208
2552:10.1007/164_2016_126
1581:(7): 1456–1478.e36.
1129:root canal treatment
885:genetically modified
848:dabigatran etexilate
577:deep-vein thrombosis
559:Vitamin K antagonist
517:), previously named
494:deep-vein thrombosis
253:Deep vein thrombosis
240:— commonly forms an
159:thrombotic disorders
8571:Antimigraine agents
8561:Antidementia agents
8464:Anti-inflammatories
8154:Medicated dressings
8094:Antihyperlipidemics
7921:Diabetes medication
7113:Carbasalate calcium
6747:. 15 September 2015
6686:Informa Health Care
6082:"Warfarin reversal"
6047:Thrombosis Research
3969:2017PLoSO..1282794C
2718:Clinical Cardiology
2374:Clinical Cardiology
1524:2015PLoSO..1044856C
928:functions (cleaves
881:protein therapeutic
852:atrial fibrillation
768:Direct Xa inhibitor
585:atrial fibrillation
238:Atrial fibrillation
187:heart–lung machines
8424:Immunosuppressants
8294:Antimycobacterials
8250:Antithyroid agents
8234:Mineralocorticoids
8038:Cardiac stimulants
8028:Cardiac glycosides
8020:cardiac therapy /
7916:Anti-obesity drugs
7800:Never to phase III
7648:Thrombolytic drugs
7364:glycosaminoglycans
6937:Antiplatelet drugs
6924:antiplatelet drugs
5492:10.2146/ajhp170785
3805:10.1002/rth2.12145
3526:10.2146/ajhp040357
2477:10.1093/bmb/ldx018
1160:has been confirmed
1077:Detecting overdose
1008:Bethesda, Maryland
953:Alcoholic beverage
581:pulmonary embolism
283:Pulmonary embolism
231:cerebral aneurysms
206:antiplatelet drugs
173:form, and various
120:chemical substance
8846:
8845:
8749:Ophthalmologicals
8459:Anabolic steroids
8362:Anticancer agents
8325:Ectoparasiticides
8045:Antihypertensives
7993:Antifibrinolytics
7810:
7809:
7642:
7641:
7512:
7511:
7242:
7241:
6826:(23): 2161–2172.
6784:10.1111/jth.15126
6695:978-0-8247-0170-3
6559:(14): 1573–1579.
6413:(12): 1131–1141.
6364:(25): 2413–2424.
6092:(11): 1132–1139.
5690:10.1111/odi.13086
5486:(15): 1095–1102.
5167:10.1111/jth.13912
5019:10.1021/ac203190k
4905:10.1021/jm030176m
4672:(14): 1597–1602.
4279:(15): 1581–1583.
4032:10.1345/aph.1D102
4026:(11): 1603–1606.
3106:(10): 1503–1519.
2730:10.1002/clc.22435
2561:978-3-319-59658-7
1713:(November 2006).
636:glycosaminoglycan
183:blood transfusion
138:animals, such as
130:, prolonging the
108:
107:
61:Class identifiers
16:(Redirected from
8876:
8835:
8814:
8813:
8798:Senotherapeutics
8652:Neuroprotectives
8647:Mood stabilizers
8546:Anti-ADHD agents
8486:Muscle relaxants
8419:Immunostimulants
8414:Immunomodulators
8246:Thyroid hormones
8184:Fertility agents
8087:Renin inhibitors
7978:Antihemorrhagics
7945:forming organs (
7931:Dietary minerals
7837:
7830:
7823:
7814:
7813:
7622:Drotrecogin alfa
7602:Antithrombin III
7453:Dermatan sulfate
7426:Oligosaccharides
7355:
7354:
7253:
7252:
6989:ADP receptor/P2Y
6942:
6941:
6905:
6898:
6891:
6882:
6881:
6862:
6861:
6843:
6811:
6805:
6804:
6786:
6762:
6756:
6755:
6753:
6752:
6741:
6735:
6734:
6717:(7–8): 683–685.
6706:
6700:
6699:
6677:
6671:
6670:
6668:
6667:
6653:
6647:
6646:
6601:
6595:
6594:
6568:
6544:
6538:
6537:
6527:
6487:
6481:
6480:
6479:
6478:
6460:"Andexanet Alfa"
6455:
6449:
6448:
6438:
6398:
6392:
6391:
6373:
6349:
6343:
6342:
6309:(6): 1116–1127.
6297:
6291:
6290:
6280:
6262:
6238:
6232:
6231:
6186:
6180:
6179:
6134:
6128:
6127:
6117:
6077:
6071:
6070:
6042:
6033:
6032:
6024:
6016:
6007:
6006:
5994:
5988:
5987:
5985:
5979:. Archived from
5978:
5970:
5961:
5960:
5958:
5957:
5951:
5945:. Archived from
5940:
5932:
5926:
5925:
5915:
5905:
5881:
5875:
5874:
5845:
5839:
5838:
5810:
5804:
5803:
5793:
5783:
5759:
5753:
5752:
5716:
5710:
5709:
5672:
5666:
5665:
5660:. Archived from
5650:
5644:
5643:
5628:
5622:
5621:
5595:
5586:
5580:
5579:
5567:
5561:
5560:
5550:
5518:
5512:
5511:
5475:
5469:
5468:
5442:
5418:
5412:
5411:
5409:
5408:
5389:
5383:
5382:
5372:
5332:
5323:
5322:
5312:
5280:
5271:
5270:
5268:
5267:
5261:
5254:
5246:
5240:
5239:
5229:
5197:
5188:
5187:
5169:
5145:
5139:
5138:
5106:
5100:
5096:
5090:
5089:
5079:
5047:
5041:
5040:
5030:
4998:
4992:
4991:
4963:
4957:
4956:
4928:
4917:
4916:
4888:
4882:
4881:
4865:
4859:
4858:
4848:
4808:
4802:
4801:
4787:
4770:(31–32): 523–4.
4755:
4749:
4748:
4712:
4706:
4705:
4661:
4655:
4654:
4610:
4604:
4603:
4593:
4569:
4563:
4562:
4552:
4542:
4518:
4512:
4509:
4499:
4466:
4436:
4435:
4433:
4408:
4399:
4398:
4354:
4348:
4347:
4311:
4305:
4304:
4268:
4262:
4261:
4259:
4258:
4244:
4238:
4237:
4192:
4186:
4185:
4183:
4182:
4168:
4162:
4161:
4117:
4111:
4110:
4066:
4060:
4059:
4015:
4009:
4008:
3998:
3980:
3948:
3942:
3941:
3924:(2–3): 259–264.
3912:
3906:
3905:
3876:
3870:
3869:
3833:
3827:
3826:
3816:
3784:
3778:
3777:
3748:
3742:
3741:
3731:
3707:
3698:
3697:
3687:
3663:
3657:
3656:
3628:
3622:
3621:
3593:
3587:
3586:
3576:
3544:
3538:
3537:
3511:
3502:
3496:
3495:
3459:
3453:
3452:
3416:
3410:
3409:
3399:
3367:
3361:
3360:
3324:
3318:
3317:
3289:
3283:
3282:
3254:
3248:
3247:
3237:
3205:
3196:
3195:
3185:
3160:(12): CD006466.
3145:
3134:
3133:
3115:
3091:
3085:
3084:
3074:
3042:
3036:
3035:
3017:
2993:
2987:
2986:
2957:
2951:
2950:
2940:
2908:
2899:
2898:
2888:
2856:
2850:
2849:
2839:
2807:
2801:
2800:
2790:
2758:
2752:
2751:
2741:
2709:
2703:
2702:
2700:
2699:
2688:
2682:
2681:
2679:
2678:
2664:
2658:
2657:
2655:
2654:
2643:
2637:
2636:
2634:
2633:
2622:
2616:
2615:
2579:
2573:
2572:
2539:
2533:
2532:
2504:
2498:
2497:
2479:
2455:
2449:
2448:
2438:
2414:
2408:
2407:
2389:
2365:
2359:
2358:
2321:
2315:
2314:
2278:
2272:
2271:
2253:
2229:
2223:
2222:
2194:
2188:
2187:
2177:
2167:
2143:
2137:
2136:
2126:
2094:
2088:
2087:
2085:
2084:
2074:"Blood Thinners"
2070:
2064:
2063:
2046:(9): 1612–1617.
2035:
2029:
2028:
1996:
1990:
1989:
1953:
1944:
1943:
1907:
1901:
1900:
1895:
1894:
1876:
1870:
1869:
1859:
1827:
1821:
1820:
1818:
1817:
1794:
1788:
1787:
1785:
1784:
1761:
1755:
1754:
1744:
1707:
1701:
1700:
1690:
1673:(Suppl 1): S11.
1656:
1650:
1649:
1613:
1605:
1599:
1598:
1570:
1562:
1556:
1555:
1545:
1535:
1518:(12): e0144856.
1501:
1495:
1494:
1484:
1442:
1436:
1435:
1425:
1385:
1379:
1378:
1332:
1324:
1318:
1317:
1315:
1313:
1294:
713:Idrabiotaparinux
354:food supplements
242:atrial appendage
92:
53:
32:
31:
21:
8884:
8883:
8879:
8878:
8877:
8875:
8874:
8873:
8849:
8848:
8847:
8842:
8838:Medicine portal
8802:
8758:
8730:
8725:
8717:Cough medicines
8712:Bronchodilators
8693:
8686:
8566:Antidepressants
8556:Anticonvulsants
8504:
8495:
8491:Bisphosphonates
8481:Corticosteroids
8443:
8430:
8402:
8393:
8377:Spindle poisons
8367:Antimetabolites
8350:
8341:
8263:
8254:
8229:Glucocorticoids
8224:Corticosteroids
8205:
8198:
8165:
8158:
8115:
8033:Antiarrhythmics
8006:
7999:
7956:Antithrombotics
7944:
7935:
7911:Antipropulsives
7907:Antidiarrhoeals
7884:
7855:
7847:
7841:
7811:
7806:
7805:
7790:Clinical trials
7769:
7741:
7651:
7638:
7585:
7508:
7464:
7367:
7362:
7350:
7341:
7317:1,3-Indandiones
7259:
7238:
7212:
7184:
7127:
7089:
7051:
7003:Thienopyridines
6992:
6983:
6931:
6912:Antithrombotics
6909:
6871:
6866:
6865:
6812:
6808:
6763:
6759:
6750:
6748:
6743:
6742:
6738:
6707:
6703:
6696:
6688:. p. 583.
6678:
6674:
6665:
6663:
6657:"Bethesda unit"
6655:
6654:
6650:
6602:
6598:
6545:
6541:
6488:
6484:
6476:
6474:
6456:
6452:
6399:
6395:
6350:
6346:
6298:
6294:
6239:
6235:
6198:(11): 879–890.
6187:
6183:
6135:
6131:
6078:
6074:
6043:
6036:
6022:
6018:
6017:
6010:
5995:
5991:
5983:
5976:
5972:
5971:
5964:
5955:
5953:
5949:
5938:
5934:
5933:
5929:
5882:
5878:
5846:
5842:
5811:
5807:
5768:BMC Oral Health
5760:
5756:
5717:
5713:
5684:(S1): 157–173.
5673:
5669:
5652:
5651:
5647:
5642:on 25 May 2011.
5630:
5629:
5625:
5604:(10): 1028–40.
5593:
5587:
5583:
5568:
5564:
5533:(20): 2541–54.
5519:
5515:
5476:
5472:
5419:
5415:
5406:
5404:
5391:
5390:
5386:
5347:(13): e017559.
5333:
5326:
5281:
5274:
5265:
5263:
5259:
5252:
5248:
5247:
5243:
5198:
5191:
5146:
5142:
5108:
5107:
5103:
5097:
5093:
5048:
5044:
4999:
4995:
4964:
4960:
4929:
4920:
4899:(13): 2551–64.
4889:
4885:
4866:
4862:
4823:(17): 287–294.
4809:
4805:
4756:
4752:
4713:
4709:
4662:
4658:
4611:
4607:
4570:
4566:
4519:
4515:
4431:
4429:
4425:ABIM Foundation
4421:Choosing Wisely
4409:
4402:
4355:
4351:
4312:
4308:
4269:
4265:
4256:
4254:
4246:
4245:
4241:
4193:
4189:
4180:
4178:
4170:
4169:
4165:
4118:
4114:
4067:
4063:
4016:
4012:
3963:(8): e0182794.
3949:
3945:
3913:
3909:
3877:
3873:
3834:
3830:
3785:
3781:
3749:
3745:
3708:
3701:
3664:
3660:
3629:
3625:
3594:
3590:
3545:
3541:
3520:(15): 1574–81.
3509:
3503:
3499:
3460:
3456:
3421:Pharmacotherapy
3417:
3413:
3382:(6668): 233–4.
3368:
3364:
3325:
3321:
3290:
3286:
3255:
3251:
3206:
3199:
3146:
3137:
3092:
3088:
3043:
3039:
3008:(21): 2689–96.
2994:
2990:
2958:
2954:
2909:
2902:
2857:
2853:
2808:
2804:
2773:(7): CD012269.
2759:
2755:
2710:
2706:
2697:
2695:
2690:
2689:
2685:
2676:
2674:
2666:
2665:
2661:
2652:
2650:
2645:
2644:
2640:
2631:
2629:
2624:
2623:
2619:
2580:
2576:
2562:
2540:
2536:
2505:
2501:
2456:
2452:
2415:
2411:
2366:
2362:
2322:
2318:
2279:
2275:
2230:
2226:
2195:
2191:
2144:
2140:
2095:
2091:
2082:
2080:
2078:medlineplus.gov
2072:
2071:
2067:
2036:
2032:
1997:
1993:
1954:
1947:
1908:
1904:
1892:
1890:
1877:
1873:
1828:
1824:
1815:
1813:
1795:
1791:
1782:
1780:
1762:
1758:
1708:
1704:
1657:
1653:
1606:
1602:
1563:
1559:
1502:
1498:
1459:(2): CD010222.
1443:
1439:
1386:
1382:
1325:
1321:
1311:
1309:
1296:
1295:
1291:
1286:
1264:
1237:
1217:thromboembolism
1119:
1101:
1079:
1069:
1016:
988:
964:
962:Reversal agents
958:
896:
877:
860:
812:
806:
770:
764:
721:
698:
680:
628:
561:
555:
507:
438:St. John's wort
350:
326:
324:Adverse effects
269:Factor V Leiden
265:Hypercoagulable
226:
88:
56:
28:
23:
22:
18:Anticoagulation
15:
12:
11:
5:
8882:
8872:
8871:
8866:
8861:
8859:Anticoagulants
8844:
8843:
8841:
8840:
8829:
8824:
8819:
8807:
8804:
8803:
8801:
8800:
8795:
8790:
8785:
8783:Contrast media
8780:
8774:
8772:
8760:
8759:
8757:
8756:
8751:
8745:
8743:
8736:sensory organs
8732:
8731:
8729:
8728:
8723:
8719:
8714:
8709:
8703:
8701:
8688:
8687:
8685:
8684:
8679:
8674:
8669:
8664:
8659:
8654:
8649:
8644:
8635:
8634:
8633:
8628:
8623:
8613:
8608:
8603:
8598:
8593:
8588:
8583:
8581:Antipsychotics
8578:
8573:
8568:
8563:
8558:
8553:
8551:Antiaddictives
8548:
8543:
8538:
8537:
8536:
8531:
8521:
8515:
8513:
8506:nervous system
8497:
8496:
8494:
8493:
8488:
8483:
8478:
8476:Antirheumatics
8473:
8472:
8471:
8461:
8455:
8453:
8432:
8431:
8429:
8428:
8427:
8426:
8421:
8410:
8408:
8395:
8394:
8392:
8391:
8390:
8389:
8384:
8382:Antineoplastic
8379:
8374:
8369:
8358:
8356:
8343:
8342:
8340:
8339:
8334:
8329:
8328:
8327:
8322:
8317:
8315:Antiprotozoals
8310:Antiparasitics
8307:
8302:
8297:
8290:Antibacterials
8286:Antimicrobials
8282:
8280:
8256:
8255:
8253:
8252:
8243:
8238:
8237:
8236:
8231:
8221:
8215:
8213:
8200:
8199:
8197:
8196:
8191:
8186:
8181:
8175:
8173:
8160:
8159:
8157:
8156:
8151:
8149:Antipsoriatics
8146:
8141:
8136:
8130:
8128:
8117:
8116:
8114:
8113:
8112:
8111:
8106:
8101:
8091:
8090:
8089:
8084:
8079:
8077:ACE inhibitors
8067:
8062:
8057:
8052:
8047:
8042:
8041:
8040:
8035:
8030:
8016:
8014:
8005:cardiovascular
8001:
8000:
7998:
7997:
7996:
7995:
7990:
7985:
7975:
7974:
7973:
7968:
7966:Anticoagulants
7963:
7952:
7950:
7937:
7936:
7934:
7933:
7928:
7923:
7918:
7913:
7904:
7899:
7894:
7893:
7892:
7887:
7882:
7878:
7867:
7865:
7849:
7848:
7840:
7839:
7832:
7825:
7817:
7808:
7807:
7804:
7803:
7802:
7801:
7798:
7787:
7781:
7775:
7774:
7771:
7770:
7768:
7767:
7762:
7757:
7751:
7749:
7743:
7742:
7740:
7739:
7734:
7729:
7719:
7714:
7709:
7704:
7703:
7702:
7697:
7689:
7688:
7687:
7682:
7677:
7672:
7657:
7655:
7644:
7643:
7640:
7639:
7637:
7636:
7631:
7626:
7625:
7624:
7614:
7609:
7604:
7599:
7593:
7591:
7587:
7586:
7584:
7583:
7578:
7573:
7568:
7563:
7558:
7549:
7548:
7547:
7542:
7537:
7522:
7520:
7514:
7513:
7510:
7509:
7507:
7506:
7501:
7496:
7491:
7486:
7481:
7475:
7473:
7466:
7465:
7463:
7462:
7461:
7460:
7455:
7450:
7440:
7439:
7438:
7433:
7423:
7422:
7421:
7416:
7411:
7406:
7401:
7396:
7391:
7386:
7375:
7373:
7352:
7343:
7342:
7340:
7339:
7333:
7328:
7323:
7314:
7309:
7304:
7299:
7294:
7289:
7279:
7277:
7250:
7248:Anticoagulants
7244:
7243:
7240:
7239:
7237:
7236:
7231:
7226:
7220:
7218:
7214:
7213:
7211:
7210:
7205:
7200:
7194:
7192:
7186:
7185:
7183:
7182:
7181:
7180:
7175:
7165:
7164:
7163:
7158:
7153:
7137:
7135:
7129:
7128:
7126:
7125:
7120:
7115:
7110:
7105:
7099:
7097:
7095:COX inhibitors
7091:
7090:
7088:
7087:
7082:
7077:
7072:
7066:
7064:
7053:
7052:
7050:
7049:
7048:
7047:
7042:
7037:
7022:
7021:
7020:
7015:
7010:
6999:
6997:
6990:
6985:
6984:
6982:
6981:
6976:
6971:
6966:
6961:
6956:
6950:
6948:
6939:
6933:
6932:
6920:anticoagulants
6908:
6907:
6900:
6893:
6885:
6879:
6878:
6870:
6869:External links
6867:
6864:
6863:
6806:
6757:
6736:
6701:
6694:
6672:
6661:Biology Online
6648:
6613:(8): 217–224.
6596:
6539:
6502:(2): 238–245.
6482:
6450:
6393:
6344:
6292:
6233:
6181:
6146:(3): 477–480.
6129:
6072:
6034:
6008:
5989:
5986:on 2012-11-15.
5962:
5927:
5876:
5840:
5805:
5754:
5727:(7): 923–932.
5711:
5667:
5664:on 2006-03-18.
5645:
5623:
5581:
5578:on 2014-07-19.
5562:
5513:
5470:
5433:(3): e005969.
5413:
5384:
5324:
5295:(1): 348–352.
5272:
5241:
5189:
5160:(2): 209–219.
5140:
5113:. 2019-07-16.
5101:
5091:
5062:(4): 505–520.
5042:
5013:(5): 2416–23.
4993:
4958:
4939:(7): 1372–92.
4918:
4883:
4860:
4803:
4750:
4723:(4): e40–e42.
4707:
4656:
4621:(3): 289–293.
4605:
4564:
4533:(4): 193–203.
4513:
4511:
4510:
4467:
4437:, which cites
4400:
4365:(2): 155–173.
4349:
4306:
4263:
4239:
4204:(6): 671–681.
4187:
4163:
4128:(3): 242–245.
4112:
4077:(6): 416–444.
4061:
4010:
3943:
3907:
3888:(1): 242–249.
3871:
3828:
3799:(4): 678–683.
3779:
3743:
3699:
3658:
3623:
3588:
3559:(5): 1504–10.
3539:
3497:
3454:
3411:
3362:
3319:
3284:
3249:
3197:
3135:
3086:
3057:(9): 243–256.
3037:
2988:
2952:
2923:(1): 432–438.
2900:
2851:
2822:(5): 770–783.
2802:
2753:
2704:
2692:"CHA2DS2-VASc"
2683:
2659:
2638:
2617:
2574:
2560:
2534:
2499:
2450:
2409:
2360:
2316:
2273:
2244:(4): 301–318.
2224:
2205:(2): 315–352.
2189:
2158:(4): 123–128.
2138:
2109:(3): 194–204.
2089:
2065:
2030:
1991:
1964:(5): 514–524.
1945:
1918:(3): 583–593.
1902:
1871:
1822:
1789:
1756:
1702:
1651:
1600:
1557:
1496:
1437:
1380:
1319:
1308:. 26 July 2021
1288:
1287:
1285:
1282:
1281:
1280:
1275:
1270:
1263:
1260:
1236:
1233:
1197:
1196:
1193:
1190:
1164:
1161:
1154:
1151:
1148:
1115:
1113:
1112:
1109:
1097:
1075:
1068:
1065:
1064:
1063:
1053:
1046:sodium citrate
1038:
1015:
1014:Laboratory use
1012:
987:
984:
980:andexanet alfa
963:
960:
956:
955:
950:
945:
933:
895:
892:
876:
873:
859:
856:
808:Main article:
805:
802:
772:Drugs such as
766:Main article:
763:
760:
720:
717:
716:
715:
710:
705:
697:
694:
679:
676:
627:
624:
610:The coumarins
554:
551:
506:
503:
406:horse chestnut
349:
346:
325:
322:
298:
297:
294:
291:
285:
280:
275:
272:
267:states (e.g.,
262:
256:
250:
245:
225:
222:
177:anticoagulant
149:As a class of
106:
105:
99:
98:
94:
93:
86:
80:
79:
78:External links
75:
74:
69:
63:
62:
58:
57:
54:
46:
45:
37:
36:
27:Class of drugs
26:
9:
6:
4:
3:
2:
8881:
8870:
8869:Medical signs
8867:
8865:
8862:
8860:
8857:
8856:
8854:
8839:
8834:
8830:
8828:
8825:
8823:
8820:
8818:
8809:
8808:
8805:
8799:
8796:
8794:
8791:
8789:
8786:
8784:
8781:
8779:
8776:
8775:
8773:
8770:
8766:
8761:
8755:
8752:
8750:
8747:
8746:
8744:
8741:
8737:
8733:
8727:
8720:
8718:
8715:
8713:
8710:
8708:
8707:Decongestants
8705:
8704:
8702:
8699:
8695:
8689:
8683:
8680:
8678:
8675:
8673:
8670:
8668:
8665:
8663:
8660:
8658:
8655:
8653:
8650:
8648:
8645:
8643:
8639:
8636:
8632:
8629:
8627:
8626:Dissociatives
8624:
8622:
8619:
8618:
8617:
8616:Hallucinogens
8614:
8612:
8609:
8607:
8604:
8602:
8599:
8597:
8594:
8592:
8589:
8587:
8584:
8582:
8579:
8577:
8574:
8572:
8569:
8567:
8564:
8562:
8559:
8557:
8554:
8552:
8549:
8547:
8544:
8542:
8539:
8535:
8532:
8530:
8527:
8526:
8525:
8522:
8520:
8517:
8516:
8514:
8511:
8507:
8502:
8498:
8492:
8489:
8487:
8484:
8482:
8479:
8477:
8474:
8470:
8467:
8466:
8465:
8462:
8460:
8457:
8456:
8454:
8451:
8447:
8441:
8437:
8433:
8425:
8422:
8420:
8417:
8416:
8415:
8412:
8411:
8409:
8406:
8400:
8396:
8388:
8385:
8383:
8380:
8378:
8375:
8373:
8370:
8368:
8365:
8364:
8363:
8360:
8359:
8357:
8354:
8348:
8344:
8338:
8335:
8333:
8330:
8326:
8323:
8321:
8320:Anthelmintics
8318:
8316:
8313:
8312:
8311:
8308:
8306:
8303:
8301:
8298:
8295:
8291:
8287:
8284:
8283:
8281:
8278:
8274:
8270:
8266:
8261:
8257:
8251:
8247:
8244:
8242:
8239:
8235:
8232:
8230:
8227:
8226:
8225:
8222:
8220:
8217:
8216:
8214:
8211:
8207:
8201:
8195:
8192:
8190:
8187:
8185:
8182:
8180:
8177:
8176:
8174:
8171:
8167:
8164:genitourinary
8161:
8155:
8152:
8150:
8147:
8145:
8144:Antipruritics
8142:
8140:
8137:
8135:
8132:
8131:
8129:
8126:
8122:
8118:
8110:
8107:
8105:
8102:
8100:
8097:
8096:
8095:
8092:
8088:
8085:
8083:
8080:
8078:
8075:
8074:
8073:
8072:
8068:
8066:
8063:
8061:
8060:Beta blockers
8058:
8056:
8053:
8051:
8048:
8046:
8043:
8039:
8036:
8034:
8031:
8029:
8026:
8025:
8024:
8023:
8018:
8017:
8015:
8012:
8008:
8002:
7994:
7991:
7989:
7986:
7984:
7981:
7980:
7979:
7976:
7972:
7969:
7967:
7964:
7962:
7961:Antiplatelets
7959:
7958:
7957:
7954:
7953:
7951:
7948:
7942:
7938:
7932:
7929:
7927:
7924:
7922:
7919:
7917:
7914:
7912:
7908:
7905:
7903:
7900:
7898:
7895:
7891:
7888:
7886:
7879:
7877:
7874:
7873:
7872:
7869:
7868:
7866:
7863:
7859:
7854:
7850:
7846:
7838:
7833:
7831:
7826:
7824:
7819:
7818:
7815:
7799:
7797:
7794:
7793:
7791:
7788:
7785:
7782:
7780:
7777:
7776:
7772:
7766:
7763:
7761:
7758:
7756:
7753:
7752:
7750:
7748:
7747:Non-medicinal
7744:
7738:
7735:
7733:
7730:
7728:
7724:
7720:
7718:
7717:Streptokinase
7715:
7713:
7710:
7708:
7705:
7701:
7698:
7696:
7693:
7692:
7690:
7686:
7683:
7681:
7678:
7676:
7673:
7671:
7668:
7667:
7666:
7662:
7659:
7658:
7656:
7654:
7653:fibrinolytics
7649:
7645:
7635:
7632:
7630:
7627:
7623:
7620:
7619:
7618:
7615:
7613:
7610:
7608:
7605:
7603:
7600:
7598:
7595:
7594:
7592:
7588:
7582:
7579:
7577:
7574:
7572:
7569:
7567:
7564:
7562:
7559:
7557:
7553:
7550:
7546:
7543:
7541:
7538:
7536:
7533:
7532:
7531:
7527:
7524:
7523:
7521:
7519:
7515:
7505:
7502:
7500:
7497:
7495:
7492:
7490:
7487:
7485:
7482:
7480:
7477:
7476:
7474:
7471:
7467:
7459:
7456:
7454:
7451:
7449:
7446:
7445:
7444:
7441:
7437:
7434:
7432:
7429:
7428:
7427:
7424:
7420:
7417:
7415:
7412:
7410:
7407:
7405:
7402:
7400:
7397:
7395:
7392:
7390:
7387:
7385:
7382:
7381:
7380:
7377:
7376:
7374:
7371:
7365:
7360:
7356:
7353:
7348:
7344:
7338:
7334:
7332:
7329:
7327:
7324:
7322:
7318:
7315:
7313:
7310:
7308:
7307:Phenprocoumon
7305:
7303:
7300:
7298:
7295:
7293:
7292:Coumatetralyl
7290:
7288:
7287:Acenocoumarol
7284:
7281:
7280:
7278:
7275:
7271:
7267:
7263:
7258:
7254:
7251:
7249:
7245:
7235:
7232:
7230:
7227:
7225:
7222:
7221:
7219:
7215:
7209:
7206:
7204:
7201:
7199:
7196:
7195:
7193:
7191:
7187:
7179:
7176:
7174:
7171:
7170:
7169:
7166:
7162:
7159:
7157:
7154:
7151:
7147:
7144:
7143:
7142:
7139:
7138:
7136:
7134:
7130:
7124:
7121:
7119:
7116:
7114:
7111:
7109:
7106:
7104:
7101:
7100:
7098:
7096:
7092:
7086:
7083:
7081:
7078:
7076:
7073:
7071:
7068:
7067:
7065:
7062:
7058:
7054:
7046:
7043:
7041:
7038:
7036:
7033:
7032:
7030:
7026:
7023:
7019:
7016:
7014:
7011:
7009:
7006:
7005:
7004:
7001:
7000:
6998:
6996:
6993:
6986:
6980:
6977:
6975:
6972:
6970:
6967:
6965:
6962:
6960:
6957:
6955:
6952:
6951:
6949:
6947:
6943:
6940:
6938:
6934:
6929:
6925:
6921:
6917:
6916:thrombolytics
6913:
6906:
6901:
6899:
6894:
6892:
6887:
6886:
6883:
6876:
6873:
6872:
6859:
6855:
6851:
6847:
6842:
6837:
6833:
6829:
6825:
6821:
6817:
6810:
6802:
6798:
6794:
6790:
6785:
6780:
6776:
6772:
6768:
6761:
6746:
6740:
6732:
6728:
6724:
6720:
6716:
6712:
6705:
6697:
6691:
6687:
6683:
6676:
6662:
6658:
6652:
6644:
6640:
6636:
6632:
6628:
6624:
6620:
6616:
6612:
6608:
6600:
6592:
6588:
6584:
6580:
6576:
6572:
6567:
6562:
6558:
6554:
6550:
6543:
6535:
6531:
6526:
6521:
6517:
6513:
6509:
6505:
6501:
6497:
6493:
6486:
6473:
6469:
6465:
6461:
6454:
6446:
6442:
6437:
6432:
6428:
6424:
6420:
6416:
6412:
6408:
6404:
6397:
6389:
6385:
6381:
6377:
6372:
6367:
6363:
6359:
6355:
6348:
6340:
6336:
6332:
6328:
6324:
6320:
6316:
6312:
6308:
6304:
6296:
6288:
6284:
6279:
6274:
6270:
6266:
6261:
6256:
6252:
6248:
6244:
6237:
6229:
6225:
6221:
6217:
6213:
6209:
6205:
6201:
6197:
6193:
6185:
6177:
6173:
6169:
6165:
6161:
6157:
6153:
6149:
6145:
6141:
6133:
6125:
6121:
6116:
6111:
6107:
6103:
6099:
6095:
6091:
6087:
6083:
6076:
6068:
6064:
6060:
6056:
6052:
6048:
6041:
6039:
6030:
6029:
6021:
6015:
6013:
6004:
6000:
5993:
5982:
5975:
5969:
5967:
5952:on 2017-03-28
5948:
5944:
5937:
5931:
5923:
5919:
5914:
5909:
5904:
5899:
5895:
5891:
5887:
5880:
5872:
5868:
5864:
5860:
5857:(6): 709–16.
5856:
5852:
5844:
5836:
5832:
5828:
5824:
5821:(8): 615–33.
5820:
5816:
5809:
5801:
5797:
5792:
5787:
5782:
5777:
5773:
5769:
5765:
5758:
5750:
5746:
5742:
5738:
5734:
5730:
5726:
5722:
5715:
5707:
5703:
5699:
5695:
5691:
5687:
5683:
5679:
5678:Oral Diseases
5671:
5663:
5659:
5655:
5649:
5641:
5637:
5633:
5627:
5619:
5615:
5611:
5607:
5603:
5599:
5592:
5585:
5577:
5573:
5566:
5558:
5554:
5549:
5544:
5540:
5536:
5532:
5528:
5524:
5517:
5509:
5505:
5501:
5497:
5493:
5489:
5485:
5481:
5474:
5466:
5462:
5458:
5454:
5450:
5446:
5441:
5436:
5432:
5428:
5424:
5417:
5403:on 2017-10-26
5402:
5398:
5394:
5388:
5380:
5376:
5371:
5366:
5362:
5358:
5354:
5350:
5346:
5342:
5338:
5331:
5329:
5320:
5316:
5311:
5306:
5302:
5298:
5294:
5290:
5286:
5279:
5277:
5262:on 2017-03-28
5258:
5251:
5245:
5237:
5233:
5228:
5223:
5219:
5215:
5211:
5207:
5203:
5196:
5194:
5185:
5181:
5177:
5173:
5168:
5163:
5159:
5155:
5151:
5144:
5136:
5132:
5128:
5124:
5120:
5116:
5112:
5105:
5095:
5087:
5083:
5078:
5073:
5069:
5065:
5061:
5057:
5053:
5046:
5038:
5034:
5029:
5024:
5020:
5016:
5012:
5008:
5004:
4997:
4989:
4985:
4981:
4977:
4973:
4969:
4962:
4954:
4950:
4946:
4942:
4938:
4934:
4927:
4925:
4923:
4914:
4910:
4906:
4902:
4898:
4894:
4887:
4879:
4875:
4871:
4864:
4856:
4852:
4847:
4842:
4838:
4834:
4830:
4826:
4822:
4818:
4814:
4807:
4800:
4795:
4791:
4786:
4781:
4777:
4773:
4769:
4765:
4761:
4754:
4746:
4742:
4738:
4734:
4730:
4726:
4722:
4718:
4711:
4703:
4699:
4695:
4691:
4687:
4683:
4679:
4675:
4671:
4667:
4660:
4652:
4648:
4644:
4640:
4636:
4632:
4628:
4624:
4620:
4616:
4609:
4601:
4597:
4592:
4587:
4583:
4579:
4575:
4568:
4560:
4556:
4551:
4546:
4541:
4536:
4532:
4528:
4527:Blood Reviews
4524:
4517:
4507:
4503:
4498:
4493:
4489:
4485:
4482:(3): 133–40.
4481:
4477:
4473:
4468:
4464:
4460:
4456:
4452:
4448:
4444:
4439:
4438:
4427:
4426:
4422:
4417:
4413:
4407:
4405:
4396:
4392:
4388:
4384:
4380:
4376:
4372:
4368:
4364:
4360:
4353:
4345:
4341:
4337:
4333:
4329:
4325:
4321:
4317:
4310:
4302:
4298:
4294:
4290:
4286:
4282:
4278:
4274:
4267:
4253:
4249:
4243:
4235:
4231:
4227:
4223:
4219:
4215:
4211:
4207:
4203:
4199:
4191:
4177:
4173:
4167:
4159:
4155:
4151:
4147:
4143:
4139:
4135:
4131:
4127:
4123:
4116:
4108:
4104:
4100:
4096:
4092:
4088:
4084:
4080:
4076:
4072:
4065:
4057:
4053:
4049:
4045:
4041:
4037:
4033:
4029:
4025:
4021:
4014:
4006:
4002:
3997:
3992:
3988:
3984:
3979:
3974:
3970:
3966:
3962:
3958:
3954:
3947:
3939:
3935:
3931:
3927:
3923:
3919:
3911:
3903:
3899:
3895:
3891:
3887:
3883:
3875:
3867:
3863:
3859:
3855:
3851:
3847:
3843:
3839:
3832:
3824:
3820:
3815:
3810:
3806:
3802:
3798:
3794:
3790:
3783:
3775:
3771:
3767:
3763:
3759:
3755:
3747:
3739:
3735:
3730:
3725:
3722:(8): e355-6.
3721:
3717:
3713:
3706:
3704:
3695:
3691:
3686:
3681:
3677:
3673:
3669:
3662:
3654:
3650:
3646:
3642:
3639:(1): 122–40.
3638:
3634:
3627:
3619:
3615:
3611:
3607:
3604:(3): 459–62.
3603:
3599:
3592:
3584:
3580:
3575:
3570:
3566:
3562:
3558:
3554:
3550:
3543:
3535:
3531:
3527:
3523:
3519:
3515:
3508:
3501:
3493:
3489:
3485:
3481:
3477:
3473:
3469:
3465:
3458:
3450:
3446:
3442:
3438:
3434:
3430:
3426:
3422:
3415:
3407:
3403:
3398:
3393:
3389:
3385:
3381:
3377:
3373:
3366:
3358:
3354:
3350:
3346:
3342:
3338:
3334:
3330:
3323:
3315:
3311:
3307:
3303:
3299:
3295:
3288:
3280:
3276:
3272:
3268:
3265:(6): 453–67.
3264:
3260:
3253:
3245:
3241:
3236:
3231:
3227:
3223:
3219:
3215:
3211:
3204:
3202:
3193:
3189:
3184:
3179:
3175:
3171:
3167:
3163:
3159:
3155:
3151:
3144:
3142:
3140:
3131:
3127:
3123:
3119:
3114:
3109:
3105:
3101:
3097:
3090:
3082:
3078:
3073:
3068:
3064:
3060:
3056:
3052:
3048:
3041:
3033:
3029:
3025:
3021:
3016:
3011:
3007:
3003:
2999:
2992:
2984:
2980:
2976:
2972:
2969:(1): e12-21.
2968:
2964:
2956:
2948:
2944:
2939:
2934:
2930:
2926:
2922:
2918:
2914:
2907:
2905:
2896:
2892:
2887:
2882:
2878:
2874:
2871:(4): 386–92.
2870:
2866:
2862:
2855:
2847:
2843:
2838:
2833:
2829:
2825:
2821:
2817:
2813:
2806:
2798:
2794:
2789:
2784:
2780:
2776:
2772:
2768:
2764:
2757:
2749:
2745:
2740:
2735:
2731:
2727:
2724:(9): 555–61.
2723:
2719:
2715:
2708:
2693:
2687:
2673:
2669:
2663:
2648:
2642:
2627:
2621:
2613:
2609:
2605:
2601:
2597:
2593:
2589:
2585:
2578:
2571:
2567:
2563:
2557:
2553:
2549:
2545:
2544:Heart Failure
2538:
2530:
2526:
2522:
2518:
2515:(3): 359–70.
2514:
2510:
2503:
2495:
2491:
2487:
2483:
2478:
2473:
2469:
2465:
2461:
2454:
2446:
2442:
2437:
2432:
2429:(8): 976–90.
2428:
2424:
2420:
2413:
2405:
2401:
2397:
2393:
2388:
2383:
2380:(5): 357–65.
2379:
2375:
2371:
2364:
2356:
2352:
2348:
2344:
2340:
2336:
2332:
2328:
2320:
2312:
2308:
2304:
2300:
2296:
2292:
2288:
2284:
2277:
2269:
2265:
2261:
2257:
2252:
2247:
2243:
2239:
2235:
2228:
2220:
2216:
2212:
2208:
2204:
2200:
2193:
2185:
2181:
2176:
2171:
2166:
2161:
2157:
2153:
2149:
2142:
2134:
2130:
2125:
2120:
2116:
2112:
2108:
2104:
2100:
2093:
2079:
2075:
2069:
2061:
2057:
2053:
2049:
2045:
2041:
2034:
2026:
2022:
2018:
2014:
2010:
2006:
2002:
1995:
1987:
1983:
1979:
1975:
1971:
1967:
1963:
1959:
1952:
1950:
1941:
1937:
1933:
1929:
1925:
1921:
1917:
1913:
1906:
1899:
1889:. p. A12
1888:
1887:
1882:
1875:
1867:
1863:
1858:
1853:
1849:
1845:
1841:
1837:
1833:
1826:
1812:
1808:
1804:
1800:
1793:
1779:
1775:
1771:
1767:
1760:
1752:
1748:
1743:
1738:
1734:
1730:
1727:(5): 509–11.
1726:
1722:
1721:
1716:
1712:
1706:
1698:
1694:
1689:
1684:
1680:
1676:
1672:
1668:
1667:
1662:
1655:
1647:
1643:
1639:
1635:
1631:
1627:
1624:(5): 565–76.
1623:
1619:
1618:
1612:
1604:
1596:
1592:
1588:
1584:
1580:
1576:
1575:
1569:
1561:
1553:
1549:
1544:
1539:
1534:
1529:
1525:
1521:
1517:
1513:
1512:
1507:
1500:
1492:
1488:
1483:
1478:
1474:
1470:
1466:
1462:
1458:
1454:
1453:
1448:
1441:
1433:
1429:
1424:
1419:
1415:
1411:
1407:
1403:
1399:
1395:
1391:
1384:
1376:
1372:
1368:
1364:
1360:
1356:
1352:
1348:
1344:
1340:
1336:
1331:
1323:
1307:
1303:
1302:Health A to Z
1299:
1293:
1289:
1279:
1276:
1274:
1271:
1269:
1266:
1265:
1259:
1257:
1252:
1250:
1246:
1242:
1232:
1228:
1226:
1222:
1218:
1214:
1210:
1206:
1202:
1194:
1191:
1189:
1185:
1181:
1177:
1173:
1169:
1165:
1162:
1159:
1155:
1152:
1149:
1146:
1145:
1144:
1142:
1136:
1134:
1130:
1125:
1120:
1118:
1110:
1107:
1106:
1105:
1102:
1100:
1095:
1091:
1088:
1083:
1080:
1078:
1073:
1061:
1057:
1054:
1051:
1047:
1042:
1039:
1036:
1033:
1032:
1031:
1029:
1026:
1021:
1011:
1009:
1005:
1001:
997:
993:
992:Bethesda unit
983:
981:
977:
972:
970:
959:
954:
951:
949:
946:
943:
942:
937:
934:
931:
927:
923:
920:
916:
912:
909:
908:
907:
905:
901:
891:
888:
886:
882:
872:
868:
865:
855:
853:
849:
845:
841:
837:
833:
829:
825:
821:
817:
811:
801:
799:
795:
791:
787:
783:
779:
775:
769:
759:
756:
754:
748:
744:
742:
738:
734:
730:
726:
714:
711:
709:
706:
703:
700:
699:
693:
691:
688:
684:
675:
673:
669:
665:
664:
659:
658:
653:
649:
645:
641:
637:
633:
623:
621:
617:
613:
608:
606:
602:
598:
597:phenprocoumon
594:
593:acenocoumarol
590:
586:
582:
578:
574:
570:
566:
560:
550:
548:
544:
540:
536:
532:
528:
524:
520:
516:
512:
502:
499:
495:
490:
488:
484:
482:
478:
474:
470:
466:
461:
459:
455:
451:
447:
443:
439:
435:
431:
427:
423:
419:
415:
411:
407:
403:
399:
395:
391:
387:
383:
379:
375:
371:
367:
363:
359:
355:
345:
341:
339:
334:
330:
321:
317:
315:
311:
305:
303:
296:Heart failure
295:
292:
289:
286:
284:
281:
279:
276:
273:
270:
266:
263:
261:
257:
254:
251:
249:
246:
243:
239:
236:
235:
234:
232:
221:
219:
214:
211:
207:
202:
200:
196:
192:
188:
184:
180:
176:
172:
168:
164:
160:
156:
152:
147:
145:
141:
137:
133:
132:clotting time
129:
125:
121:
117:
116:blood thinner
113:
112:anticoagulant
104:
100:
95:
91:
87:
85:
81:
76:
73:
70:
68:
64:
59:
52:
47:
44:
43:
38:
35:Anticoagulant
33:
30:
19:
8621:Psychedelics
8591:Aphrodisiacs
8265:infestations
8241:Sex hormones
8194:Sex hormones
8139:Cicatrizants
8069:
8055:Vasodilators
8022:antianginals
8019:
7965:
7871:stomach acid
7870:
7746:
7737:Fibrinolysin
7707:Anistreplase
7685:Desmoteplase
7680:Tenecteplase
7581:Ximelagatran
7431:Fondaparinux
7370:antithrombin
7326:Diphenadione
7247:
7203:Dipyridamole
7146:Dipyridamole
7085:Treprostinil
7080:Prostacyclin
6959:Eptifibatide
6919:
6823:
6819:
6809:
6777:(1): 20–29.
6774:
6770:
6760:
6749:. Retrieved
6739:
6714:
6710:
6704:
6681:
6675:
6664:. Retrieved
6660:
6651:
6610:
6606:
6599:
6556:
6552:
6542:
6499:
6495:
6485:
6475:, retrieved
6463:
6453:
6410:
6406:
6396:
6361:
6357:
6347:
6306:
6302:
6295:
6253:(8): 362–6.
6250:
6246:
6236:
6195:
6191:
6184:
6143:
6139:
6132:
6089:
6085:
6075:
6050:
6046:
6026:
6002:
5992:
5981:the original
5954:. Retrieved
5947:the original
5942:
5930:
5893:
5889:
5879:
5854:
5850:
5843:
5818:
5814:
5808:
5771:
5767:
5757:
5724:
5720:
5714:
5681:
5677:
5670:
5662:the original
5657:
5648:
5640:the original
5635:
5626:
5601:
5597:
5584:
5576:the original
5565:
5530:
5526:
5516:
5483:
5479:
5473:
5430:
5426:
5416:
5405:. Retrieved
5401:the original
5396:
5387:
5344:
5340:
5292:
5288:
5264:. Retrieved
5257:the original
5244:
5209:
5205:
5157:
5153:
5143:
5110:
5104:
5094:
5059:
5055:
5045:
5010:
5006:
4996:
4971:
4967:
4961:
4945:10.2741/4462
4936:
4932:
4896:
4892:
4886:
4880:(3): 97–102.
4877:
4873:
4863:
4820:
4816:
4806:
4797:
4767:
4763:
4753:
4720:
4716:
4710:
4669:
4665:
4659:
4618:
4614:
4608:
4584:(4): 57–72.
4581:
4577:
4567:
4530:
4526:
4516:
4479:
4475:
4449:(1): 37–41.
4446:
4442:
4432:15 September
4430:, retrieved
4419:
4362:
4358:
4352:
4319:
4315:
4309:
4276:
4272:
4266:
4255:. Retrieved
4251:
4242:
4201:
4197:
4190:
4179:. Retrieved
4175:
4166:
4125:
4121:
4115:
4074:
4070:
4064:
4023:
4019:
4013:
3960:
3956:
3946:
3921:
3917:
3910:
3885:
3881:
3874:
3844:(1): 67–71.
3841:
3837:
3831:
3796:
3792:
3782:
3757:
3753:
3746:
3719:
3715:
3678:(2): 241–6.
3675:
3671:
3661:
3636:
3632:
3626:
3601:
3597:
3591:
3556:
3552:
3542:
3517:
3513:
3500:
3467:
3463:
3457:
3427:(5): 674–7.
3424:
3420:
3414:
3379:
3375:
3365:
3332:
3328:
3322:
3300:(2): 352–4.
3297:
3293:
3287:
3262:
3258:
3252:
3217:
3213:
3157:
3153:
3103:
3099:
3089:
3054:
3050:
3040:
3005:
3001:
2991:
2966:
2962:
2955:
2920:
2916:
2868:
2864:
2854:
2819:
2815:
2805:
2770:
2766:
2756:
2721:
2717:
2707:
2696:. Retrieved
2686:
2675:. Retrieved
2671:
2662:
2651:. Retrieved
2641:
2630:. Retrieved
2620:
2587:
2583:
2577:
2543:
2537:
2512:
2508:
2502:
2470:(1): 79–89.
2467:
2463:
2453:
2426:
2422:
2412:
2377:
2373:
2363:
2330:
2326:
2319:
2289:(1): 24–30.
2286:
2282:
2276:
2241:
2237:
2227:
2202:
2198:
2192:
2155:
2151:
2141:
2106:
2102:
2092:
2081:. Retrieved
2077:
2068:
2043:
2039:
2033:
2011:(1): 53–63.
2008:
2004:
1994:
1961:
1957:
1915:
1911:
1905:
1897:
1891:. Retrieved
1884:
1874:
1839:
1835:
1825:
1814:. Retrieved
1802:
1792:
1781:. Retrieved
1769:
1759:
1724:
1718:
1711:Pirmohamed M
1705:
1670:
1664:
1654:
1621:
1615:
1603:
1578:
1572:
1560:
1515:
1509:
1499:
1456:
1450:
1440:
1397:
1393:
1383:
1338:
1334:
1322:
1310:. Retrieved
1301:
1292:
1273:CHADS2 score
1253:
1238:
1229:
1198:
1141:root planing
1137:
1124:antiplatelet
1121:
1116:
1114:
1103:
1098:
1096:
1092:
1084:
1081:
1076:
1074:
1070:
1017:
995:
991:
989:
976:idarucizumab
973:
965:
957:
939:
897:
889:
878:
869:
861:
840:ximelagatran
813:
771:
757:
753:idarucizumab
749:
745:
722:
702:Fondaparinux
681:
668:venipuncture
661:
655:
644:antithrombin
629:
620:rodenticides
609:
562:
526:
522:
518:
514:
510:
508:
491:
485:
477:coenzyme Q10
462:
362:lumbrokinase
351:
348:Interactions
342:
335:
331:
327:
318:
314:CHA2DS2-VASc
306:
299:
227:
224:Medical uses
215:
210:thrombolytic
203:
179:dosage forms
148:
136:blood-eating
115:
111:
109:
97:Legal status
90:D00534-class
40:
29:
8864:Blood tests
8754:Otologicals
8726:antagonists
8692:respiratory
8667:Orexigenics
8662:Neurotoxins
8611:Euphoriants
8601:Entactogens
8596:Depressants
8586:Anxiolytics
8524:Anesthetics
8300:Antifungals
7897:Antiemetics
7885:antagonists
7786:from market
7607:Defibrotide
7535:Bivalirudin
7504:Rivaroxaban
7443:Heparinoids
7436:Idraparinux
7337:Tioclomarol
7331:Phenindione
7321:Clorindione
7224:Cloricromen
7018:Ticlopidine
7008:Clopidogrel
6553:Circulation
6003:www.fda.gov
5099:PMC7213950.
4550:2434/476466
3716:Circulation
3002:Circulation
2590:: 206–218.
2103:Circulation
1842:(1): 11–7.
1245:factor XIIa
1205:ticlopidine
1201:clopidogrel
1168:paracetamol
1052:, and more.
904:diagnostics
828:bivalirudin
774:rivaroxaban
729:rivaroxaban
719:Direct oral
708:Idraparinux
690:coagulation
612:brodifacoum
605:phenindione
535:rivaroxaban
426:pomegranate
378:cranberries
358:nattokinase
290:from stents
199:rodenticide
175:intravenous
151:medications
124:coagulation
103:In Wikidata
8853:Categories
8677:Stimulants
8657:Nootropics
8631:Deliriants
8606:Entheogens
8541:Anorectics
8519:Analgesics
8372:Alkylating
8305:Antivirals
8260:infections
8134:Emollients
7988:Coagulants
7858:metabolism
7712:Monteplase
7629:Ramatroban
7612:Nafamostat
7597:Abelacimab
7576:Melagatran
7561:Dabigatran
7556:Argatroban
7499:Otamixaban
7484:Betrixaban
7472:("xabans")
7458:Sulodexide
7448:Danaparoid
7419:Tinzaparin
7409:Parnaparin
7404:Nadroparin
7399:Enoxaparin
7394:Dalteparin
7389:Certoparin
7349:inhibitors
7297:Dicoumarol
7198:Cilostazol
7178:Terutroban
7156:Picotamide
7045:Ticagrelor
7029:nucleoside
7025:Nucleotide
6995:inhibitors
6974:Sibrafiban
6751:2020-02-20
6666:2009-02-14
6477:2020-01-23
6464:StatPearls
5956:2020-01-09
5407:2016-03-09
5266:2016-03-09
4316:The Lancet
4257:2020-01-23
4181:2020-01-23
3470:(4): 740.
3335:(3): 251.
2698:2014-08-15
2677:2020-01-23
2653:2014-08-15
2632:2014-08-15
2083:2020-01-23
1893:2008-01-06
1816:2020-01-23
1803:StatPearls
1783:2020-01-23
1770:StatPearls
1766:"Warfarin"
1284:References
1249:factor XIa
1213:ticagrelor
1184:diclofenac
1158:hemostasis
1060:glycolysis
1020:laboratory
930:fibrinogen
911:Batroxobin
864:hemostatic
836:dabigatran
832:argatroban
798:eribaxaban
786:betrixaban
741:betrixaban
725:dabigatran
672:Vacutainer
616:difenacoum
601:atromentin
579:(DVT) and
543:betrixaban
531:dabigatran
487:Grapefruit
473:cat's claw
446:wheatgrass
430:red clover
352:Foods and
288:Restenosis
144:mosquitoes
42:Drug class
8827:ATC codes
8793:Dressings
8778:Antidotes
8642:Sedatives
8638:Hypnotics
8347:malignant
8204:endocrine
8050:Diuretics
7983:Platelets
7943:and blood
7902:Laxatives
7796:Phase III
7784:Withdrawn
7700:Urokinase
7695:Saruplase
7675:Reteplase
7670:Alteplase
7617:Protein C
7571:Inogatran
7566:Efegatran
7552:Univalent
7545:Lepirudin
7540:Desirudin
7489:Darexaban
7414:Reviparin
7384:Bemiparin
7347:Factor Xa
7283:Coumarins
7260:(inhibit
7234:Vorapaxar
7208:Triflusal
7173:Terbogrel
7161:Terbogrel
7150:+ aspirin
7123:Triflusal
7118:Indobufen
7108:Aloxiprin
7070:Beraprost
7040:Elinogrel
7035:Cangrelor
7013:Prasugrel
6979:Tirofiban
6969:Roxifiban
6964:Orbofiban
6954:Abciximab
6858:244132392
6801:222320654
6627:0340-6245
6575:0009-7322
6516:0340-6245
6427:0028-4793
6380:0028-4793
6323:0340-6245
6269:2307-8960
6212:0340-6245
6160:0340-6245
6106:0021-9746
6053:: 22–31.
5706:169034257
5465:212640015
5449:1941-7705
5361:2047-9980
5135:241319098
5127:2643-4652
4837:1866-0452
4686:1465-6566
4635:1828-0447
4395:210842354
4379:1747-4086
4293:1079-2082
4252:Drugs.com
4218:0094-6176
4142:0957-5235
4091:0312-5963
4040:1060-0280
3987:1932-6203
3174:1465-1858
2333:: 68–73.
1473:1469-493X
1414:2982-6799
1375:260192613
1359:0743-684X
1345:: 481–6.
1256:milvexian
1209:prasugrel
1180:ibuprofen
1004:coagulant
948:Vitamin E
824:lepirudin
794:letaxaban
790:darexaban
648:factor Xa
402:green tea
258:Ischemic
8672:Serenics
8337:Vaccines
8104:Fibrates
7926:Vitamins
7876:Antacids
7526:Bivalent
7494:Edoxaban
7479:Apixaban
7312:Warfarin
7229:Ditazole
7075:Iloprost
7031:analogs
6850:34780683
6793:33047462
6731:24463230
6643:28694620
6635:22627883
6583:21900088
6534:27853809
6472:30137783
6445:27573206
6388:26559317
6339:37404563
6331:20352166
6287:25133148
6220:27488143
6176:45458169
6124:15509671
6067:29258056
5922:28228727
5871:24120910
5835:21073495
5800:26822674
5741:29627150
5698:31140701
5632:"Exanta"
5618:16148288
5557:21878434
5508:49418996
5500:29941506
5457:32148102
5379:32538234
5319:30504331
5236:30176738
5184:46865986
5176:29193737
5086:26862016
5037:22283665
4988:25088334
4974:: 60–8.
4953:27100512
4913:12801218
4855:29789105
4794:24069072
4745:44103560
4737:29861320
4702:52099757
4694:30152249
4651:25807727
4643:26972708
4600:30697449
4559:28196633
4506:20514175
4463:18691773
4387:31958251
4344:25712161
4336:27375038
4234:24822900
4226:27232386
4158:33380206
4150:27023878
4107:22389544
4056:43777757
4048:14565795
4005:28797065
3957:PLOS ONE
3938:11535373
3902:26852855
3866:22447084
3858:11711691
3823:30349886
3774:18574270
3738:16923760
3694:16432096
3583:18495950
3534:16030366
3492:20482173
3484:11564060
3449:28632135
3441:12741443
3357:38261767
3279:13171021
3244:22315269
3192:29285754
3130:52922296
3122:30286834
3081:28651452
3024:17515465
2983:26765643
2947:30504343
2895:22224125
2846:31539334
2797:35833913
2748:26418409
2694:. MDCalc
2649:. MDCalc
2628:. MDCalc
2612:36716760
2604:28366835
2570:28233177
2529:27650345
2486:28910988
2445:26916489
2355:49588203
2347:29957264
2311:24650202
2303:27734187
2268:43296498
2260:27461564
2219:26867832
2184:31903386
2133:25995317
2060:28844512
2025:25963956
1978:28359135
1940:52039169
1932:30122182
1866:25671002
1811:30725747
1778:29261922
1751:17061959
1697:26046056
1646:23824484
1638:17484616
1595:28668628
1552:26716830
1511:PLOS One
1491:32030721
1432:24850962
1367:21780018
1262:See also
1235:Research
1188:naproxen
1174:such as
936:Hementin
926:platelet
887:goats).
782:edoxaban
778:apixaban
737:edoxaban
733:apixaban
663:in vitro
652:thrombin
569:warfarin
565:coumarin
547:edoxaban
539:apixaban
498:bed rest
458:feverfew
442:turmeric
410:licorice
382:fish oil
370:bilberry
338:necrosis
310:HAS-BLED
195:warfarin
191:dialysis
67:ATC code
8529:General
8436:muscles
8405:L03–L04
8401:disease
8353:L01–L02
8349:disease
8099:Statins
7765:Oxalate
7755:Citrate
7732:Brinase
7530:Hirudin
7359:Heparin
7335:Other:
6841:9540352
6525:6260118
6436:5568772
6278:4133427
6228:4733615
6168:9065997
6115:1770479
5913:5296357
5791:4731944
5749:4697607
5548:3295208
5370:7670541
5310:6246023
5227:6714855
5077:2137061
5028:3296823
4846:5974258
4785:3782018
4591:6334188
4497:2787576
4301:9706183
4099:8792056
3996:5552262
3965:Bibcode
3814:6178656
3653:6985765
3618:1113236
3574:4571144
3406:2522326
3397:1835547
3349:6688309
3314:6876290
3235:3278051
3183:6389337
3072:5562140
3032:8881388
2938:6245998
2886:3236169
2837:6754204
2788:9281623
2739:6490831
2494:3800129
2396:8723593
2175:6796304
2124:4765082
1986:1981707
1857:4307693
1742:1885167
1688:4437941
1543:4696796
1520:Bibcode
1482:7004894
1423:4028456
1176:aspirin
1056:Oxalate
1041:Citrate
1028:calcium
820:hirudin
657:in vivo
632:Heparin
573:heparin
481:spinach
469:avocado
465:alfalfa
454:danshen
434:soybean
398:ginseng
218:heparin
155:therapy
140:leeches
118:, is a
8836:
8815:
8763:other
8694:system
8446:joints
8399:immune
8206:system
8166:system
8007:system
7779:WHO-EM
7727:Ancrod
7721:Other
7368:(bind
7361:group/
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2404:103327
2402:
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2266:
2258:
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2172:
2131:
2121:
2058:
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1976:
1938:
1930:
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1749:
1739:
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1479:
1471:
1430:
1420:
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1365:
1357:
1312:2 June
1221:stroke
1172:NSAIDs
1044:plain
826:, and
603:, and
450:willow
448:, and
422:papaya
414:niacin
394:ginkgo
390:ginger
386:garlic
374:celery
260:stroke
189:, and
185:bags,
171:tablet
8817:Drugs
8534:Local
8501:brain
8440:bones
7941:blood
7665:r-tPA
7590:Other
7217:Other
6854:S2CID
6797:S2CID
6639:S2CID
6587:S2CID
6335:S2CID
6224:S2CID
6172:S2CID
6023:(PDF)
5984:(PDF)
5977:(PDF)
5950:(PDF)
5939:(PDF)
5774:: 5.
5745:S2CID
5702:S2CID
5594:(PDF)
5504:S2CID
5461:S2CID
5260:(PDF)
5253:(PDF)
5180:S2CID
5131:S2CID
4741:S2CID
4698:S2CID
4647:S2CID
4391:S2CID
4340:S2CID
4230:S2CID
4154:S2CID
4103:S2CID
4052:S2CID
3862:S2CID
3754:Chest
3510:(PDF)
3488:S2CID
3445:S2CID
3353:S2CID
3214:Chest
3126:S2CID
3028:S2CID
2608:S2CID
2490:S2CID
2400:S2CID
2351:S2CID
2307:S2CID
2264:S2CID
2199:Chest
1982:S2CID
1936:S2CID
1642:S2CID
1410:eISSN
1371:S2CID
1355:eISSN
1341:(8).
922:venom
919:snake
917:from
915:toxin
894:Other
525:) or
523:NOACs
515:DOACs
505:Types
418:onion
128:blood
8444:and
8121:skin
7760:EDTA
7691:UPA
7634:REG1
7061:PGI2
6922:and
6846:PMID
6789:PMID
6727:PMID
6690:ISBN
6631:PMID
6623:ISSN
6579:PMID
6571:ISSN
6530:PMID
6512:ISSN
6468:PMID
6441:PMID
6423:ISSN
6384:PMID
6376:ISSN
6327:PMID
6319:ISSN
6283:PMID
6265:ISSN
6216:PMID
6208:ISSN
6164:PMID
6156:ISSN
6120:PMID
6102:ISSN
6063:PMID
5918:PMID
5867:PMID
5831:PMID
5796:PMID
5737:PMID
5694:PMID
5614:PMID
5553:PMID
5496:PMID
5453:PMID
5445:ISSN
5375:PMID
5357:ISSN
5315:PMID
5293:2018
5232:PMID
5172:PMID
5123:ISSN
5082:PMID
5033:PMID
4984:PMID
4949:PMID
4909:PMID
4851:PMID
4833:ISSN
4790:PMID
4733:PMID
4690:PMID
4682:ISSN
4639:PMID
4631:ISSN
4596:PMID
4555:PMID
4502:PMID
4459:PMID
4434:2014
4383:PMID
4375:ISSN
4332:PMID
4297:PMID
4289:ISSN
4222:PMID
4214:ISSN
4146:PMID
4138:ISSN
4095:PMID
4087:ISSN
4044:PMID
4036:ISSN
4001:PMID
3983:ISSN
3934:PMID
3898:PMID
3854:PMID
3819:PMID
3770:PMID
3734:PMID
3690:PMID
3649:PMID
3614:PMID
3579:PMID
3530:PMID
3480:PMID
3437:PMID
3402:PMID
3345:PMID
3310:PMID
3275:PMID
3240:PMID
3188:PMID
3170:ISSN
3118:PMID
3077:PMID
3020:PMID
2979:PMID
2943:PMID
2921:2018
2891:PMID
2842:PMID
2793:PMID
2771:2022
2744:PMID
2600:PMID
2566:PMID
2556:ISBN
2525:PMID
2482:PMID
2441:PMID
2392:PMID
2343:PMID
2299:PMID
2256:PMID
2215:PMID
2180:PMID
2129:PMID
2056:PMID
2021:PMID
1974:PMID
1928:PMID
1862:PMID
1807:PMID
1774:PMID
1747:PMID
1693:PMID
1634:PMID
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1548:PMID
1487:PMID
1469:ISSN
1457:2020
1428:PMID
1363:PMID
1314:2023
1247:and
1025:bind
913:, a
834:and
780:and
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687:APTT
614:and
545:and
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366:beer
244:clot
208:and
167:pill
163:Oral
157:for
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8765:ATC
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6928:B01
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6836:PMC
6828:doi
6824:385
6779:doi
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6557:124
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6504:doi
6500:117
6431:PMC
6415:doi
6411:375
6366:doi
6362:373
6311:doi
6307:103
6273:PMC
6255:doi
6200:doi
6196:116
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6110:PMC
6094:doi
6055:doi
6051:162
5908:PMC
5898:doi
5859:doi
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5776:doi
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5686:doi
5606:doi
5602:353
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