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mouse neurons to fluoresce, and optogenetically silencing a subset of neurons. This discovery repudiated the pre-existing theory that newborn neurons carried new memories. Rather, Losonczy found that the firing of older cells was more localised and newborn neurons fire indiscriminately, not taking on
385:
Jeffrey D Zaremba, Anastasia
Diamantopoulou, Nathan B Danielson, Andres D Grosmark, Patrick W Kaifosh, John C Bowler, Zhenrui Liao, Fraser T Sparks, Joseph A Gogos & Attila Losonczy. Impaired hippocampal place cell dynamics in a mouse model of the 22q11.2 microdeletion. Nature Neuroscience,
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in the mouse hippocampus and compare them with mature neurons as the mice traveled through subtly different contexts. No previous work had been able to study the roles of newborn and mature cells in the dentate gyrus as it was not previously possible to image the dentate gyrus at all, much less
359:. To overcome these obstacles, Losonczy and his collaborators pioneered and implemented several novel techniques to be used simultaneously including the implantation of a miniature microscope into the brains of mice,
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a stereotyped firing pattern until they got older. This suggests that the more excitable newborn neurons are better at encoding new stimuli than more mature neurons. This discovery is significant, as
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Varga, V; Losonczy, A; Zemelman, BV; Borhegyi, Z; Nyiri, G; Domonkos, G; Hangya, B; Holderith, B; Magee, JC; Freund, TF (2009). "Fast synaptic subcortical control of hippocampal circuits".
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393:, Balough ME, Cloidt MA, Drew JD, Hen R, Losonczy A*, and Kheirbek MA. Distinct contribution of adultborn hippocampal granule cells to context encoding
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in
Neurobiology in 2004 with a thesis entitled "Underlying mechanisms of short-term synaptic plasticity at identified central synapses," advised by
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Lovett-Barron, M; Kaifosh, P; Kheirbek, MA; Danielson, N; Zaremba, JD; Reardon, TR; Turi, GF; Hen, R; Zemelman, BV; Losonczy (2014).
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Losonczy, A; Makara, JK; Magee, JC (2008). "Compartmentalized dendritic plasticity and input feature storage in neurons".
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989:; Balough, Elizabeth; Goldberg, Alexander; Drew, Liam; Hen, Rene; Losonczy, Attila; Kheirbek, Mazen (6 April 2016).
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could thus be prevented. This discovery is significant to research into the mechanism psychiatric disorders such as
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218:. In 2003, he moved from Hungary to the United States; from 2003 to 2006, Losonczy was a postdoctoral fellow at
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319:. By deactivating these interneurons, Losonczy showed that fear memories could be suppressed and contextual
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399:"Gating hippocampal activity, plasticity and memory by entorhinal cortex long-range inhibition"
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Basu, J; Zaremba, JD; Cheung, SK; Hitti, FL; Zemelman, BV; Losonczy, A; Siegelbaum, SA (2016).
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In 2015, Losonczy and his PhD student Nathan
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observe individual dentate gyrus cells in detail, as it lies too deep in the
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in two consecutive years, 2014 and 2015. Losonczy is a journal reviewer for
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Danielson, Nathan; Kaifosh, Patrick; Lovett-Barron, Matthew; Tsai, Joseph;
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in animal models as well as the pathology of cognitive memory deficits in
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Losonczy and his PhD student
Matthew Lovett-Barron uncovered the role of
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such as PTSD and anxiety. Losonczy is currently working on developing
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are thought to be associated with failures in pattern separation.
151:. Losonczy's main area of research is on the relationship between
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851:"Scientists Get Their First Glimpse At How New Memories Are Born"
794:"Dendritic Inhibition in the Hippocampus Supports Fear Learning"
768:"Modeling the Brain on 'Replay': A Q&A with Attila Losonczy"
442:"Dendritic inhibition in the hippocampus supports fear learning"
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From 2007 to 2009, Losonczy worked as a research specialist at
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as a professor. Since 2010, Losonczy has been a member of the
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Lovett-Barron, Matthew; Losonczy, Attila (21 February 2014).
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Danielson N, Zaremba JD, Kaifosh P, Lovett-Barron M, Tsai J,
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Medical School in 1999, and subsequently the PhD degree at
877:"The Mysteries of How Newborn Cells May Help Form Memories"
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and behavior, specifically with regard to learning in the
961:"Newborn neurons observed in a live brain for first time"
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Losonczy, A; Zemelman, BV; Vaziri, A; Magee, JC (2010).
206:, Hungary, in 1974. He received the MD degree from the
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265:Young Investigator Award. Losonczy was awarded the
226:. In 2006, he served as a postdoctoral fellow with
257:for Brain Science. In 2011, Losonczy was named a
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190:to simultaneously image hundreds of hippocampal
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342:. To perform this study, Losonczy used
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932:"Observing Nascent Neurons in Action"
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149:Columbia University Medical Center
117:Columbia University Medical Center
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712:"Fear suppressing neurons found"
304:in fear memory formation in the
738:"Central Directions of the Lab"
616:Losonczy, A; Magee, JC (2006).
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244:Howard Hughes Medical Institute
162:His group conducts research on
147:, Professor of Neuroscience at
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325:post-traumatic stress disorder
261:. In 2013, he was awarded the
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374:posttraumatic stress disorder
1007:10.1016/j.neuron.2016.02.019
635:10.1016/j.neuron.2006.03.016
271:National Institute of Health
246:, again working with Magee.
202:Attila Losonczy was born in
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1088:Columbia University faculty
683:"Attila Losonczy Biography"
172:neurodegenerative disorders
143:(born 1974) is a Hungarian
32:1974 (age 49–50)
10:
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849:Futurism (15 March 2016).
220:Louisiana State University
1093:University of PĂ©cs alumni
1083:Hungarian neuroscientists
1053:Full list of publications
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338:in memory formation and
198:Early life and education
79:Young Investigator Award
1078:People from Nagykanizsa
818:10.1126/science.1247485
548:10.1126/science.1178307
466:10.1126/science.1247485
415:10.1126/science.aaa5694
770:. The Kavli Foundation
182:imaging methods using
744:. Columbia University
688:. Columbia University
361:genetically modifying
344:two-photon microscopy
212:Semmelweis University
184:two-photon microscopy
176:psychiatric disorders
56:Semmelweis University
1048:Losonczy Lab website
875:Hernandez, Daniela.
766:Borthwick, Lindsey.
107:Circuit neuroscience
959:Hamzelou, Jessica.
881:Wall Street Journal
810:2014Sci...343..857L
593:10.1038/nature06725
585:2008Natur.452..436L
497:Nature Neuroscience
458:2014Sci...343..857L
288:Nature Neuroscience
251:Columbia University
736:Losonczy, Attila.
340:pattern separation
208:University of PĂ©cs
164:spatial navigation
51:University of PĂ©cs
804:(6173): 857–863.
579:(7186): 436–441.
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153:neural networks
141:Attila Losonczy
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38:, Hungary
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970:11 April
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475:4018419
454:Bibcode
446:Science
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366:anxiety
334:in the
313:imaging
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180:in vivo
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