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BCG vaccine

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576:) results in a nonspecific immune response against mycobacteria. Administering BCG to someone who already has a nonspecific immune response against mycobacteria does not augment the response already there. BCG will, therefore, appear not to be efficacious because that person already has a level of immunity and BCG is not adding to that immunity. This effect is called masking because the effect of BCG is masked by environmental mycobacteria. Clinical evidence for this effect was found in a series of studies performed in parallel in adolescent school children in the UK and Malawi. In this study, the UK school children had a low baseline cellular immunity to mycobacteria which was increased by BCG; in contrast, the Malawi school children had a high baseline cellular immunity to mycobacteria and this was not significantly increased by BCG. Whether this natural immune response is protective is not known. An alternative explanation is suggested by mouse studies; immunity against mycobacteria stops BCG from replicating and so stops it from producing an immune response. This is called the block hypothesis. 2250:, France) in 1908. Their work included subculturing virulent strains of the tuberculosis bacillus and testing different culture media. They noted a glycerin-bile-potato mixture grew bacilli that seemed less virulent, and changed the course of their research to see if repeated subculturing would produce a strain that was attenuated enough to be considered for use as a vaccine. The BCG strain was isolated after subculturing 239 times during 13 years from virulent strain on glycerine potato medium. The research continued throughout World War I until 1919, when the now avirulent bacilli were unable to cause tuberculosis disease in research animals. Calmette and Guerin transferred to the Paris 632: 1856: 2092:. Because the living bacilli evolve to make the best use of available nutrients, they become less well-adapted to human blood and can no longer induce disease when introduced into a human host. Still, they are similar enough to their wild ancestors to provide some degree of immunity against human tuberculosis. The BCG vaccine can be anywhere from 0 to 80% effective in preventing tuberculosis for a duration of 15 years; however, its protective effect appears to vary according to geography and the lab in which the vaccine strain was grown. 958: 924: 1054: 1952: 42: 1504: 1472: 1408: 1760: 990: 1728: 1600: 1150: 1920: 1440: 1310: 1278: 1022: 1632: 1118: 1086: 892: 705: 1888: 1696: 1376: 1536: 1246: 1214: 1824: 1568: 1664: 1182: 1342: 1792: 1971: 1964: 1868: 1836: 1804: 1772: 1740: 1612: 1548: 1484: 1361: 1354: 1322: 1258: 1226: 1194: 1162: 1098: 1066: 943: 936: 904: 2174: 8809: 1939: 1932: 1907: 1900: 1875: 1843: 1811: 1779: 1747: 1715: 1708: 1683: 1676: 1651: 1644: 1619: 1587: 1580: 1555: 1523: 1516: 1491: 1459: 1452: 1427: 1420: 1395: 1388: 1329: 1297: 1290: 1265: 1233: 1201: 1169: 1137: 1130: 1105: 1073: 1041: 1034: 1009: 1002: 977: 970: 911: 4633: 561:, United Kingdom, examined children born to families who originated from the Indian subcontinent (where vaccine efficacy had previously been shown to be zero). The trial showed a 64% protective effect, which is very similar to the figure derived from other UK trials, thus arguing against the genetic variation hypothesis. 2288:(WHO)). Because of opposition, however, it only became widely used after World War II. From 1945 to 1948, relief organizations (International Tuberculosis Campaign or Joint Enterprises) vaccinated over eight million babies in eastern Europe and prevented the predicted typical increase of tuberculosis after a major war. 2265:, 251 infants were vaccinated in the first 10 days of life; 173 developed tuberculosis and 72 died. It was subsequently discovered that the BCG administered there had been contaminated with a virulent strain that was being stored in the same incubator, which led to legal action against the manufacturers of the vaccine. 5112: 2112:, which owns the Brazilian substrain M. bovis BCG Moreau which is less reactogenic than vaccines including other BCG strains. Pacis BCG, made from the Montréal (Institut Armand-Frappier) strain, was first marketed by Urocor in about 2002. Urocor was since acquired by Dianon Systems. Evans Vaccines (a subsidiary of 4625: 545:
A number of possible reasons for the variable efficacy of BCG in different countries have been proposed. None has been proven, some have been disproved, and none can explain the lack of efficacy in both low tuberculosis-burden countries (US) and high tuberculosis-burden countries (India). The reasons
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A 1994 systematic review found that BCG reduces the risk of getting tuberculosis by about 50%. Differences in effectiveness depend on region, due to factors such as genetic differences in the populations, changes in environment, exposure to other bacterial infections, and conditions in the laboratory
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As of January 2021, twenty BCG trials are in various clinical stages. As of October 2022, the results are extremely mixed. A 15-month trial involving people thrice-vaccinated over the two years before the pandemic shows positive results in preventing infection in BCG-naive people with type
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gave the permission for Sanofi to resume production of BCG. A 2018 analysis of the global supply concluded that the supplies are adequate to meet forecast BCG vaccine demand, but that risks of shortages remain, mainly due to dependence of 75 percent of WHO pre-qualified supply on just two suppliers.
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The age of the person and the frequency with which BCG is given has always varied from country to country. The WHO recommends childhood BCG for all countries with a high incidence of tuberculosis and/or high leprosy burden. This is a partial list of historic and active BCG practice around the globe.
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in Denmark has marketed BCG vaccine prepared using Danish strain 1331. The production of BCG Danish strain 1331 and its distribution was later undertaken by AJVaccines company since the ownership transfer of SSI's vaccine production business to AJ Vaccines Holding A/S which took place on 16 January
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immediately, otherwise without treatment it could spread the infection, causing severe damage to vital organs. An abscess is not always associated with incorrect administration, and it is one of the more common complications that can occur with the vaccination. Numerous medical studies on treatment
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The duration of protection of BCG is not clearly known. In those studies showing a protective effect, the data are inconsistent. The MRC study showed protection waned to 59% after 15 years and to zero after 20 years; however, a study looking at Native Americans immunized in the 1930s found evidence
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Rates of protection against tuberculosis infection vary widely and protection lasts up to 20 years. Among children, it prevents about 20% from getting infected and among those who do get infected, it protects half from developing disease. The vaccine is given by injection into the skin. No evidence
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is common, one dose is recommended in healthy babies as soon after birth as possible. In areas where tuberculosis is not common, only children at high risk are typically immunized, while suspected cases of tuberculosis are individually tested for and treated. Adults who do not have tuberculosis and
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Iran: Iran's vaccination policy implemented in 1984. Vaccination with the Bacillus Calmette–Guerin (BCG) is among the most important tuberculosis control strategies in Iran . According to Iranian neonatal vaccination policy, BCG has been given as a single dose at children aged <6 years, shortly
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Japan: In Japan, BCG was introduced in 1951, given typically at age 6. From 2005 it is administered between five and eight months after birth, and no later than a child's first birthday. BCG was administered no later than the fourth birthday until 2005, and no later than six months from birth from
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When BCG is used for bladder cancer, around 2.9% of treated patients discontinue immunotherapy due to a genitourinary or systemic BCG-related infection, however while symptomatic bladder BCG infection is frequent, the involvement of other organs is very uncommon. When systemic involvement occurs,
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The most controversial aspect of BCG is the variable efficacy found in different clinical trials, which appears to depend on geography. Trials conducted in the UK have consistently shown a protective effect of 60 to 80%, but those conducted elsewhere have shown no protective effect, and efficacy
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in the pediatric age group, but its efficacy against pulmonary tuberculosis appears to be variable. Some countries have removed the BCG vaccine from routine vaccination. Two countries that have never used it routinely are the United States and the Netherlands (in both countries, it is felt that
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had demonstrated that rabbits could be infected with tuberculosis from humans; by 1868 he had found that rabbits could be infected with tuberculosis from cows, and that rabbits could be infected with tuberculosis from other rabbits. Thus, he concluded that tuberculosis was transmitted via some
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report published in December 2015, on BCG vaccine supply security, global demand increased in 2015 from 123 to 152.2 million doses. To improve security and to sources of affordable and flexible supply," UNICEF awarded seven new manufacturers contracts to produce BCG. Along with supply
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A number of different companies make BCG, sometimes using different genetic strains of the bacterium. This may result in different product characteristics. OncoTICE, used for bladder instillation for bladder cancer, was developed by Organon Laboratories (since acquired by
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plant flooded, causing problems with mold. The facility, located in Toronto, Ontario, Canada, produced BCG vaccine products made with substrain Connaught such as a tuberculosis vaccine and ImmuCYST, a BCG immunotherapeutic and bladder cancer drug. By April 2012 the
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had found dozens of documented problems with sterility at the plant including mold, nesting birds and rusted electrical conduits. The resulting closure of the plant for over two years caused shortages of bladder cancer and tuberculosis vaccines. On 29 October 2014
448:. Although no harmful effects on the fetus have been observed, there is insufficient evidence about the safety of BCG vaccination during pregnancy and therefore the vaccine is not recommended for use during pregnancy. The vaccine was originally developed from 3509:
Black GF, Weir RE, Floyd S, Bliss L, Warndorff DK, Crampin AC, et al. (April 2002). "BCG-induced increase in interferon-gamma response to mycobacterial antigens and efficacy of BCG vaccination in Malawi and the UK: two randomised controlled studies".
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and become fine powder. Sometimes the powder is sealed with vacuum in a glass ampoule. Such a glass ampoule has to be opened slowly to prevent the airflow from blowing out the powder. Then the powder has to be diluted with saline water before injecting.
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Cabas P, Rizzo M, GiuffrĂš M, Antonello RM, Trombetta C, Luzzati R, et al. (February 2021). "BCG infection (BCGitis) following intravesical instillation for bladder cancer and time interval between treatment and presentation: A systematic review".
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A systematic review and meta-analysis conducted in 2014 demonstrated that the BCG vaccine reduced infections by 19–27% and reduced progression to active tuberculosis by 71%. The studies included in this review were limited to those that used
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Fine PE, Carneiro IA, Milstein JB, Clements CJ (1999). "Chapter 8: Reasons for variable efficacy". Issues relating to the use of BCG in immunization programmes: a discussion document (Report). Geneva, Switzerland: World Health Organization.
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of these abscesses with antibiotics have been done with varying results, but the consensus is once pus is aspirated and analysed, provided no unusual bacilli are present, the abscess will generally heal on its own in a matter of weeks.
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Brazil introduced universal BCG immunization in 1967–1968, and the practice continues until now. According to Brazilian law, BCG is given again to professionals of the health sector and to people close to patients with tuberculosis or
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South Korea, Singapore, Taiwan and Malaysia. In these countries, BCG was given at birth and again at age 12. In Malaysia and Singapore from 2001, this policy was changed to once only at birth. South Korea stopped re-vaccination in
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Houghton BB, Chalasani V, Hayne D, Grimison P, Brown CS, Patel MI, et al. (May 2013). "Intravesical chemotherapy plus bacille Calmette-GuĂ©rin in non-muscle invasive bladder cancer: a systematic review with meta-analysis".
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availability from existing manufacturers, and a "new WHO prequalified vaccine" the total supply will be "sufficient to meet both suppressed 2015 demand carried over to 2016, as well as total forecast demand through 2016–2018."
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India and Pakistan: India and Pakistan introduced BCG mass immunization in 1948, the first countries outside Europe to do so. In 2015, millions of infants were denied BCG vaccine in Pakistan for the first time due to shortage
3017:"The role of BCG vaccine in the prevention and control of tuberculosis in the United States. A joint statement by the Advisory Council for the Elimination of Tuberculosis and the Advisory Committee on Immunization Practices" 7530: 2397: 3823:
Rentsch CA, BirkhĂ€user FD, Biot C, Gsponer JR, Bisiaux A, Wetterauer C, et al. (October 2014). "Bacillus Calmette-GuĂ©rin strain differences have an impact on clinical outcome in bladder cancer immunotherapy".
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Use of the BCG vaccine may provide protection against COVID-19. However, epidemiologic observations in this respect are ambiguous. The WHO does not recommend its use for prevention as of 12 January 2021.
820:), it can cause disseminated or life-threatening infection. The documented incidence of this happening is less than one per million immunizations given. In 2007, the WHO stopped recommending BCG for infants with 2025:
Sri Lanka: In Sri Lanka, The National Policy of Sri Lanka is to give BCG vaccination to all newborn babies immediately after birth. BCG vaccination is carried out under the Expanded Programme of Immunisation
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is most frequently used because the local complication rate is smallest when that site is used. Nonetheless, the buttock is an alternative site of administration because it provides better cosmetic outcomes.
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Nummi A, JÀrvinen R, Sairanen J, Huotari K (4 May 2019). "A retrospective study on tolerability and complications of bacillus Calmette-Guérin (BCG) instillations for non-muscle-invasive bladder cancer".
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in this disease. While the mechanism is unclear, it appears a local immune reaction is mounted against the tumor. Immunotherapy with BCG prevents recurrence in up to 67% of cases of superficial bladder
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Aronson NE, Santosham M, Comstock GW, Howard RS, Moulton LH, Rhoades ER, et al. (May 2004). "Long-term efficacy of BCG vaccine in American Indians and Alaska Natives: A 60-year follow-up study".
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Colditz GA, Brewer TF, Berkey CS, Wilson ME, Burdick E, Fineberg HV, et al. (March 1994). "Efficacy of BCG vaccine in the prevention of tuberculosis. Meta-analysis of the published literature".
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Genetic variation in populations: Differences in genetic make-up of different populations may explain the difference in efficacy. The Birmingham BCG trial was published in 1988. The trial, based in
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response is required for an effective immune response to tuberculous infection, concurrent infection with various parasites produces a simultaneous Th2 response, which blunts the effect of BCG.
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Trunz BB, Fine P, Dye C (April 2006). "Effect of BCG vaccination on childhood tuberculous meningitis and miliary tuberculosis worldwide: a meta-analysis and assessment of cost-effectiveness".
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skin test is a contraindication to BCG due to the risk of severe local inflammation and scarring; it does not indicate any immunity. BCG is also contraindicated in certain people who have
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South Africa: In South Africa, the BCG Vaccine is given routinely at birth, to all newborns, except those with clinically symptomatic AIDS. The vaccination site is in the right shoulder.
809:) and disseminated BCG infection are rare complications of BCG vaccination, but potentially life-threatening. Systemic antituberculous therapy may be helpful in severe complications. 241: 8859: 7522: 2429: 6213: 5554: 5142: 5345: 3620:"Failure of the Mycobacterium bovis BCG vaccine: some species of environmental mycobacteria block multiplication of BCG and induction of protective immunity to tuberculosis" 2389: 2521: 2216:
in preventing smallpox, established during the 18th century, scientists thought to find a corollary in tuberculosis by drawing a parallel between bovine tuberculosis and
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1 diabetes. On the other hand, a 5-month trial shows that re-vaccinating with BCG does not help prevent infection in healthcare workers. Both of these trials were
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of superficial forms of bladder cancer. Since the late 1970s, evidence has become available that instillation of BCG into the bladder is an effective form of
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From p. 189: "Considering all these facts, I feel justified in maintaining that human tuberculosis differs from bovine and cannot be transmitted to cattle."
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Brandau S, Suttmann H (July 2007). "Thirty years of BCG immunotherapy for non-muscle invasive bladder cancer: a success story with room for improvement".
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and therefore being able to accurately detect active disease is more beneficial to society than vaccinating against a condition that is relatively rare).
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When given for bladder cancer, the vaccine is not injected through the skin, but is instilled into the bladder through the urethra using a soft catheter.
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Rodrigues LC, Diwan VK, Wheeler JG (December 1993). "Protective effect of BCG against tuberculous meningitis and miliary tuberculosis: a meta-analysis".
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The United States has never used mass immunization of BCG due to the rarity of tuberculosis in the US, relying instead on the detection and treatment of
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were used as involuntary participants in BCG vaccine trials between 1933 and 1945. In 1928, the BCG vaccine was adopted by the Health Committee of the
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The characteristic raised scar that BCG immunization leaves is often used as proof of prior immunization. This scar must be distinguished from that of
537:(WHO), although the development of new vaccines with greater efficacy against adult pulmonary tuberculosis may be needed to make substantial progress. 8712: 2461: 6167: 3117: 2015:
Mongolia: All newborns are vaccinated with BCG. Previously, the vaccine was also given at ages 8 and 15, although this is no longer common practice.
6271: 3604: 2580: 465:. As of 2004, the vaccine is given to about 100 million children per year globally. However, it is not commonly administered in the United States. 4840: 7855: 4818: 2276:
in Saskatchewan, was among the pioneers in developing the practice of vaccination against tuberculosis. In Canada, more than 600 children from
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The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023)
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Canadian Indigenous communities receive the BCG vaccine, and in the province of Quebec the vaccine was offered to children until the mid-70s.
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or tuberculosis meningitis, so it is still extensively used even in countries where efficacy against pulmonary tuberculosis is negligible.
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A complete atlas of past and present practice has been generated. As of 2022, 155 countries offer the BCG vaccine in their schedule.
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The 100th anniversary of the BCG vaccine was in 2021. It remains the only vaccine licensed against tuberculosis, which is an ongoing
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have not been previously immunized, but are frequently exposed, may be immunized, as well. BCG also has some effectiveness against
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Styblo K, Meijer J (March 1976). "Impact of BCG vaccination programmes in children and young adults on the tuberculosis problem".
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where the vaccine is grown, including genetic differences between the strains being cultured and the choice of growth medium.
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BCG vaccine should be given intradermally. If given subcutaneously, it may induce local infection and spread to the regional
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2017. Japan BCG Laboratory markets its vaccine, based on the Tokyo 172 substrain of Pasteur BCG, in 50 countries worldwide.
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abscesses can occur due to haematogenous (carried by the blood) and lymphangiomatous spread. Regional bone infection (BCG
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An apparatus (4–5 cm length, with 9 short needles) used for BCG vaccination in Japan, shown with ampules of BCG and saline
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Mak TK, Hesseling AC, Hussey GD, Cotton MF (September 2008). "Making BCG vaccination programmes safer in the HIV era".
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may also form with some scarring after healing. Side effects are more common and potentially more severe in those with
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Australia: BCG vaccination was used between 1950s and mid 1980. BCG is not part of routine vaccination since mid 1980.
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BCG has been one of the most successful immunotherapies. BCG vaccine has been the "standard of care for patients with
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of BCG vaccination on overall mortality in low income countries, or for its reducing other health problems including
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Interference by concurrent parasitic infection: In another hypothesis, simultaneous infection with parasites such as
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Hawgood BJ (August 2007). "Albert Calmette (1863-1933) and Camille Guérin (1872-1961): the C and G of BCG vaccine".
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presented differences between human and bovine tuberculosis, which he reported to Koch. By 1901 Koch distinguished
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Gabriele F, Katragkou A, Roilides E (October 2014). "BCG vaccination policy in Greece: time for another review?".
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World Health Organization (May 2007). "Revised BCG vaccination guidelines for infants at risk for HIV infection".
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is conducting a study comparing the efficacy of injected versus inhaled BCG vaccine in already-vaccinated adults.
8339: 8307: 8302: 8131: 6641:"Bovine tuberculosis and the establishment of an eradication program in the United States: role of veterinarians" 6115: 2312: 2088:, that has lost its ability to cause disease in humans. It is specially subcultured in a culture medium, usually 226: 134: 6509:(Tuberculosis inoculation; that's now an incontestable fact. Henceforth this malady should be placed among the 2514:"BCG Vaccine- bacillus Calmette–Guerin substrain TICE live antigen injection, powder, lyophilized, for solution" 2069:
New Zealand: BCG Immunisation was first introduced for 13 yr olds in 1948. Vaccination was phased out 1963–1990.
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BCG immunization generally causes some pain and scarring at the site of injection. The main adverse effects are
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Brimnes N (2007). "Vikings against tuberculosis: the International Tuberculosis Campaign in India, 1948-1951".
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Serious side effects are rare. Often, redness, swelling, and mild pain occur at the site of injection. A small
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Kowalewicz-Kulbat M, Locht C (July 2017). "BCG and protection against inflammatory and auto-immune diseases".
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Other names include "Vaccin Bilié de Calmette et Guérin vaccine" and "Bacille de Calmette et Guérin vaccine".
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Kaur G, Danovaro-Holliday MC, Mwinnyaa G, Gacic-Dobo M, Francis L, Grevendonk J, et al. (October 2023).
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Morocco: In Morocco, the BCG was introduced in 1949. The policy is BCG vaccination at birth, to all newborns.
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side effects from vaccinations at 3–4 months. Some municipalities recommend an earlier immunization schedule.
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Sadeghi-Shanbestari M, Ansarin K, Maljaei SH, Rafeey M, Pezeshki Z, Kousha A, et al. (December 2009).
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Brandt L, Feino Cunha J, Weinreich Olsen A, Chilima B, Hirsch P, Appelberg R, et al. (February 2002).
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Upton CM, van Wijk RC, Mockeliunas L, Simonsson US, McHarry K, van den Hoogen G, et al. (June 2022).
5105:"ΔÎčαÎșÎżÏ€Îź της Î”Ï†Î±ÏÎŒÎżÎłÎźÏ‚ ÎșαΞολÎčÎșÎżÏ αΜτÎčφυΌατÎčÎșÎżÏ ΔΌÎČολÎčÎ±ÏƒÎŒÎżÏ (ΔΌÎČόλÎčÎż BCG) στα παÎčÎŽÎčÎŹ της Α΄ Î”Î·ÎŒÎżÏ„ÎčÎșÎżÏ 2016" 3180:
Fine PE (November 1995). "Variation in protection by BCG: implications of and for heterologous immunity".
739:, then a local abscess may form (a "BCG-oma") that can sometimes ulcerate, and may require treatment with 6178: 5871:"Immunologic aspects of patients with disseminated bacille Calmette-Guerin disease in north-west of Iran" 3113: 2369: 426: 5682: 5426: 2587: 8799: 8317: 7754: 7737: 2208: 2113: 175: 67: 5039: 4534: 3897:
Lamm DL, Blumenstein BA, Crawford ED, Montie JE, Scardino P, Grossman HB, et al. (October 1991).
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Natukunda A, Zirimenya L, Nassuuna J, Nkurunungi G, Cose S, Elliott AM, et al. (September 2022).
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Faustman DL, Lee A, Hostetter ER, Aristarkhova A, Ng NC, Shpilsky GF, et al. (September 2022).
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Faustman DL, Lee A, Hostetter ER, Aristarkhova A, Ng NC, Shpilsky GF, et al. (September 2022).
4810: 2543: 8834: 8322: 8287: 8282: 8277: 7651: 6234: 5513: 530: 6004: 4848: 4657:"Bacillus Calmette-Guérin (BCG) vaccination patterns in the province of Québec, Canada, 1956-1974" 3722:"Do successful tuberculosis vaccines need to be immunoregulatory rather than merely Th1-boosting?" 8768: 8701: 8682: 8478: 8450: 8412: 8407: 8387: 7910: 7039:
Darrah PA, Zeppa JJ, Maiello P, Hackney JA, Wadsworth MH, Hughes TK, et al. (January 2020).
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is evaluating BCG as an adjuvant to autologous tumour cells used as a cancer vaccine in stage II
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Interference by nontuberculous mycobacteria: Exposure to environmental mycobacteria (especially
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Biering-SĂžrensen S, Aaby P, Napirna BM, Roth A, Ravn H, Rodrigues A, et al. (March 2012).
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Roy A, Eisenhut M, Harris RJ, Rodrigues LC, Sridhar S, Habermann S, et al. (August 2014).
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World Health Organization (February 2018). "BCG vaccines: WHO position paper – February 2018".
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liver and lungs are the first organs to be affected (1 week after the last BCG instillation).
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Most countries in Central and South America have universal BCG immunizations, as does Mexico.
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Brosch R, Gordon SV, Garnier T, Eiglmeier K, Frigui W, Valenti P, et al. (March 2007).
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China: Introduced in 1930s. Increasingly widespread after 1949. Majority inoculated by 1979.
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Rieckmann A, Villumsen M, SĂžrup S, Haugaard LK, Ravn H, Roth A, et al. (April 2017).
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and respiratory infections when given early, with greater benefit the earlier it is used.
112: 8: 8550: 8516: 8402: 8225: 8168: 8163: 8109: 7940: 7808: 7780: 7732: 3939: 2084: 1315: 857: 565: 488:. BCG vaccine can be administered after birth intradermally. BCG vaccination can cause a 450: 441: 8220: 7960: 7444: 7171: 7115: 7056: 6771: 6744: 5756: 4587: 3418: 668:
use BCG as an additive to provide an initial stimulation of the person's immune systems.
8583: 8417: 8158: 8119: 8104: 7980: 7965: 7950: 7870: 7788: 7647: 7621: 7596: 7572: 7545: 7463: 7428: 7404: 7379: 7355: 7330: 7311: 7263: 7238: 7193: 7137: 7075: 7040: 7021: 6811:"First Nation infants subject to "human experimental work" for TB vaccine in 1930s-40s" 6680: 6667: 6640: 6406: 6381: 6357: 6332: 5897: 5870: 5846: 5821: 5775: 5740: 5395: 5368: 4941: 4928: 4903: 4443: 4400: 4320: 4271: 4244: 4225: 4166: 4149: 4125: 4100: 4016: 3991: 3967: 3693: 3668: 3535: 3486: 3461: 3437: 3402: 3252: 3227: 3226:
Venkataswamy MM, Goldberg MF, Baena A, Chan J, Jacobs WR, Porcelli SA (February 2012).
3205: 3090: 3065: 2932: 2907: 2885: 2836: 2809: 2785: 2768: 2746: 554:
in the BCG strains used may explain the variable efficacy reported in different trials.
515:
of protection even 60 years after immunization, with only a slight waning in efficacy.
80: 6716: 5806: 4431: 4388: 3644: 3619: 3523: 3193: 2258: 8829: 8706: 8673: 8506: 8347: 8237: 8126: 7987: 7812: 7775: 7665: 7626: 7577: 7468: 7409: 7360: 7303: 7268: 7197: 7185: 7141: 7129: 7080: 7013: 6972: 6884: 6857: 6776: 6672: 6411: 6362: 6059: 6039: 5931: 5902: 5851: 5780: 5585: 5465: 5461: 5400: 5260: 5086: 4933: 4678: 4592: 4435: 4392: 4357: 4324: 4312: 4276: 4229: 4217: 4171: 4130: 4021: 3959: 3920: 3879: 3841: 3800: 3795: 3770: 3744: 3698: 3649: 3574: 3555:"Effects of infection with atypical mycobacteria on BCG vaccination and tuberculosis" 3527: 3491: 3442: 3327: 3292: 3257: 3197: 3159: 3155: 3095: 3031: 2937: 2877: 2873: 2841: 2790: 2738: 2703: 2629: 2612:
Yamamoto S, Yamamoto T (November 2007). "Historical review of BCG vaccine in Japan".
2281: 2251: 791: 787: 684: 626: 551: 445: 279: 266: 253: 126: 8652: 6949:
Aaby P, Roth A, Ravn H, Napirna BM, Rodrigues A, Lisse IM, et al. (July 2011).
6684: 6382:"Preparation and properties of a freeze-dried B.C.G. vaccine of increased stability" 4404: 3971: 3940:"Towards therapeutic vaccines for colorectal carcinoma: a review of clinical trials" 3786: 3539: 3228:"In vitro culture medium influences the vaccine efficacy of Mycobacterium bovis BCG" 3209: 2889: 2750: 2239: 413: 8632: 8617: 8473: 8334: 8247: 7616: 7608: 7567: 7557: 7458: 7448: 7399: 7391: 7350: 7342: 7315: 7295: 7258: 7250: 7175: 7119: 7070: 7060: 7025: 7003: 6962: 6849: 6766: 6756: 6712: 6662: 6652: 6401: 6393: 6352: 6344: 5892: 5882: 5841: 5833: 5770: 5760: 5457: 5390: 5380: 5078: 4945: 4923: 4915: 4668: 4582: 4572: 4447: 4427: 4384: 4347: 4304: 4266: 4256: 4209: 4161: 4120: 4116: 4112: 4011: 4003: 3951: 3910: 3871: 3833: 3790: 3782: 3736: 3688: 3680: 3639: 3631: 3566: 3519: 3481: 3473: 3432: 3422: 3381: 3319: 3284: 3247: 3239: 3189: 3151: 3085: 3077: 2992: 2963: 2927: 2919: 2869: 2831: 2821: 2780: 2730: 2693: 2621: 2337: 816:
If BCG is accidentally given to an immunocompromised patient (e.g., an infant with
209: 199: 8173: 7299: 6348: 5765: 5739:
Rauniyar SK, Munkhbat E, Ueda P, Yoneoka D, Shibuya K, Nomura S (September 2020).
5419:"ІПС ЛІГА:ЗАКОН - ŃĐžŃŃ‚Đ”ĐŒĐ° ĐżĐŸŃˆŃƒĐșу, Đ°ĐœĐ°Đ»Ń–Đ·Ńƒ та ĐŒĐŸĐœŃ–Ń‚ĐŸŃ€ĐžĐœĐłŃƒ ĐœĐŸŃ€ĐŒĐ°Ń‚ĐžĐČĐœĐŸ-праĐČĐŸĐČĐŸŃ— базО" 5369:"The BCG World Atlas: a database of global BCG vaccination policies and practices" 5202:"Coronavirus: More "striking" evidence BCG vaccine might protect against Covid-19" 4673: 4656: 4308: 4213: 3740: 3635: 3243: 8813: 8637: 8435: 8242: 8200: 8086: 8066: 8036: 8019: 7945: 7935: 7865: 7804: 7800: 7749: 7612: 7453: 7346: 7008: 6991: 5385: 4187: 3875: 3837: 3717: 2349: 2235: 2097: 1509: 409: 7237:
KĂŒhtreiber WM, Tran L, Kim T, Dybala M, Nguyen B, Plager S, et al. (2018).
5483: 3915: 3898: 2625: 2483: 2238:, a French physician and bacteriologist, and his assistant and later colleague, 8774: 8501: 8392: 8352: 8232: 8053: 7992: 7562: 7395: 7180: 7155: 7124: 7099: 6761: 3570: 3407:
Proceedings of the National Academy of Sciences of the United States of America
2323: 2269: 2199: 2138: 2101: 1957: 1059: 767: 732: 721: 665: 657: 646: 622: 600:
Leprosy: BCG has a protective effect against leprosy in the range of 20 to 80%.
489: 430: 7429:"BCG epidemiology supports its protection against COVID-19? A word of caution" 7254: 7065: 6689:
From p. 2: "In 1895, Smith visited Koch in Europe and described his findings."
6137: 794:
may be required. Evidence for the treatment of these complications is scarce.
546:
for variable efficacy have been discussed at length in a WHO document on BCG.
8823: 8657: 8642: 8612: 8607: 8462: 8215: 8210: 8114: 7759: 6474:] (in French). Paris, France: J.-B. BailliĂšre et fils. pp. 528–597. 4039: 3955: 3462:"Protective effect of BCG vaccination in infant Asians: a case-control study" 3288: 3016: 2734: 2456: 2424: 2161: 2148: 2109: 2056:
Kenya: In Kenya, the BCG Vaccine is given routinely at birth to all newborns.
802: 783: 676: 584: 580: 454:, which is commonly found in cattle. While it has been weakened, it is still 41: 8014: 6967: 6950: 6397: 6272:"UPDATED: Merck again shipping BCG cancer treatment but Sanofi still is not" 5887: 3427: 3323: 33: 8734: 8377: 8272: 8205: 8146: 8141: 7821: 7712: 7692: 7630: 7581: 7472: 7413: 7364: 7307: 7272: 7189: 7133: 7084: 7041:"Prevention of tuberculosis in macaques after intravenous BCG immunization" 7017: 6976: 6861: 6780: 6676: 6415: 6366: 5906: 5855: 5837: 5784: 5404: 5090: 4937: 4682: 4655:
Rousseau MC, Conus F, Kñ K, El-Zein M, Parent MÉ, Menzies D (August 2017).
4596: 4577: 4439: 4396: 4361: 4316: 4280: 4261: 4221: 4175: 4134: 4098: 4040:"BestBets: Is medical therapy effective in the treatment of BCG abscesses?" 4025: 3963: 3883: 3845: 3804: 3769:
Tanghe A, Content J, Van Vooren JP, Portaels F, Huygen K (September 2001).
3748: 3702: 3653: 3531: 3446: 3296: 3261: 3099: 2941: 2881: 2845: 2794: 2742: 2707: 2633: 2366: 2297: 692: 650: 642: 492: 485: 455: 429:
infections. Additionally, it is sometimes used as part of the treatment of
422: 405: 204: 194: 171: 7523:"Studies found for BCG Recruiting, Active, not recruiting Studies Covid19" 6853: 6657: 6598:
See § "Two varieties of the tubercle bacillus from mammals." pp. 149-161.
5589: 5469: 5082: 3924: 3578: 3495: 3331: 3201: 3163: 3081: 3035: 3014: 8521: 8372: 8178: 8061: 7955: 7817: 7708: 7700: 5312:"Vacunas disponibles | Vacunas / Asociación Española de Vacunología" 5234:[Tuberculosis vaccination - guide for healthcare professionals]. 4919: 4007: 3477: 2213: 2195: 1861: 1477: 775: 740: 728: 120: 6528: 5367:
Zwerling A, Behr MA, Verma A, Brewer TF, Menzies D, Pai M (March 2011).
4352: 2997: 2968: 2698: 306: 8647: 8622: 8312: 8262: 7156:"The trick that could inject new life into an old tuberculosis vaccine" 5868: 5231: 4751: 4555: 4099:
Cuello-García CA, Pérez-Gaxiola G, Jiménez Gutiérrez C (January 2013).
3617: 3386: 2826: 717: 688: 635: 558: 317: 75: 7427:
Szigeti R, Kellermayer D, Trakimas G, Kellermayer R (7 October 2020).
6743:
Mitermite M, Elizari JM, Ma R, Farrell D, Gordon SV (September 2023).
6303:"Sanofi Canada vax plant again producing ImmuCyst bladder cancer drug" 3985: 3983: 3981: 3684: 2923: 2330:. Some risks must be evaluated before it can be translated to humans. 596:
BCG has protective effects against some nontuberculosis mycobacteria.
8696: 8267: 8135: 7704: 7426: 6035: 5340:[Tuberculosis (TB) - on vaccination - Public Health Agency]. 2079: 2018:
Philippines: BCG vaccine started in the Philippines in 1979 with the
1413: 645:
of bladder neck tissue due to Bacillus Calmette–GuĂ©rin used to treat
639: 106: 6920:"🔎 Vaccin BiliĂ© de Calmette et GuĂ©rin - DĂ©finition et Explications" 5803:
The National Programme for tuberculosis Control & Chest Diseases
5709: 4626:"Bacille Calmette–Guerin (BCG) Information for Health Professionals" 3666: 2262: 704: 8538: 8531: 8526: 8496: 8252: 8188: 8183: 4780: 3992:"Tuberculosis Vaccine Development: Progress in Clinical Evaluation" 3978: 2348:
As of 2017, BCG vaccine is in the early stages of being studied in
2182: 2008:
Thailand: In Thailand, the BCG vaccine is given routinely at birth.
2002: 1765: 1733: 1605: 995: 806: 526: 376: 369: 297: 148: 6492:(Sixteenth study: Tuberculosis can be transmitted by inoculation)) 5822:"SARS-CoV-2 Rates in BCG-Vaccinated and Unvaccinated Young Adults" 2581:"Freeze - dried glutamate BCG vaccine (Japan) for intradermal use" 2198:
regarded human and bovine tuberculosis as identical. But in 1895,
8257: 7696: 7594: 5659: 2001:
2005 to 2012; the schedule was changed in 2012 due to reports of
1925: 1637: 1445: 1283: 1219: 1155: 1123: 1091: 1027: 929: 897: 844: 798: 583:
changes the immune response to BCG, making it less effective. As
417: 401: 56: 7543: 7377: 8560: 8545: 7831: 6989: 6380:
Ungar J, Muggleton PW, Dudley JA, Griffiths MI (October 1962).
5518: 4901: 3768: 2316: 2261:, in particular, did much to harm it. Between 1929 and 1933 in 2217: 2125: 2105: 1893: 1829: 1701: 1669: 1573: 1541: 1381: 1251: 1187: 763: 683:
BCG has been evaluated in a number of studies as a therapy for
461:
The BCG vaccine was first used medically in 1921. It is on the
6330: 6168:"Bacillus Calmette–GuĂ©rin Vaccine Supply & Demand Outlook" 5288:[Vaccinations with general obligation]. Archived from 3274: 2858: 8555: 8440: 8041: 7975: 6379: 6331:
Cernuschi T, Malvolti S, Nickels E, Friede M (January 2018).
5694: 5418: 5040:"A Database of Global BCG Vaccination Policies and Practices" 3896: 3225: 2484:"BCG Vaccine AJV - Summary of Product Characteristics (SmPC)" 2247: 2173: 1797: 1347: 606:: BCG may protect against or delay the onset of Buruli ulcer. 4198: 3822: 3400: 3378: 2036:
Israel: BCG was given to all newborns between 1955 and 1982.
716:
is usually carried out before administering BCG. A reactive
7850: 5738: 4531:"Database of Global BCG Vaccination Policies and Practices" 4530: 2254:
in 1919. The BCG vaccine was first used in humans in 1921.
2104:). A similar application is the product of Onko BCG of the 360: 5071:
The International Journal of Tuberculosis and Lung Disease
5047: 4293: 2905: 7038: 6742: 6112:"BCG Vaccine Danish Strain 1331 – Statens Serum Institut" 5338:"Tuberkulos (TB) – om vaccination – FolkhĂ€lsomyndigheten" 5135:"A tuberkulĂłzis Ă©s a tuberkulĂłzis elleni vĂ©dƑoltĂĄs (BCG)" 5068: 4337: 3403:"Genome plasticity of BCG and impact on vaccine efficacy" 3141: 3015:
Centers for Disease Control and Prevention (April 1996).
2954: 2683: 2224:
were conducted in Italy with disastrous results, because
2143: 2040:
after birth or at first contact with the health services.
779: 8860:
World Health Organization essential medicines (vaccines)
6537:] (in French). Paris, France: Victor Masson et fils. 6263: 5547:"Coronavirus: should the UK make vaccination mandatory?" 4752:"Bacille Calmette-Guérin (BCG) Vaccine for Tuberculosis" 4417: 3937: 2807: 7236: 5366: 463:
World Health Organization's List of Essential Medicines
7285: 7212:"Novel inhaled TB vaccine | University of Oxford" 6608:
Transactions of the Association of American Physicians
6530:
De la virulence et de la spécificité de la tuberculose
6294: 5232:"Tuberkulosevaksinasjon – veileder for helsepersonell" 4654: 8797: 6883:. The Hague:Health Council of the Netherlands. 2011. 6604:"Two varieties of the tubercle bacillus from mammals" 5576:
Chen ZR, Wei XH, Zhu ZY (June 1982). "BCG in China".
5137:[Tuberculosis and tuberculosis vaccination]. 3309: 6590:"Investigations of diseases of domesticated animals" 5819: 2808:
Fuge O, Vasdev N, Allchorne P, Green JS (May 2015).
2326:, BCG shows improved rates of protection when given 518:
BCG seems to have its greatest effect in preventing
499:
appears to fall the closer one gets to the equator.
6948: 4843:[Mandatory and recommended immunizations]. 4775: 4773: 3857: 3855: 3508: 46:Microscopic image of the Calmette–GuĂ©rin bacillus, 6877:Vaccination of young children against tuberculosis 6212:, Vaccines, Blood & Biologics, 12 April 2012, 8713:Cedillo v. Secretary of Health and Human Services 6596:. 12/13. U.S. Department of Agriculture: 119–185. 6535:On the virulence and specificity of tuberculosis 6206:"April 2012 Inspectional Observations (form 483)" 5680: 2078:BCG is prepared from a strain of the attenuated ( 8821: 5710:"Millions of infants denied anti-TB vaccination" 4770: 4558:"Routine Vaccination Coverage - Worldwide, 2022" 4147: 3989: 3938:Mosolits S, Nilsson B, Mellstedt H (June 2005). 3852: 2762: 2760: 2611: 6490:"SeiziĂšme Étude: La tuberculose est inoculable" 3990:Sable SB, Posey JE, Scriba TJ (December 2019). 3861: 3221: 3219: 3010: 3008: 2901: 2899: 484:The main use of BCG is for vaccination against 7100:"Tuberculosis vaccine finds an improved route" 6594:Annual Report of the Bureau of Animal Industry 3715: 7673: 7097: 6324: 6235:"Sanofi Pasteur Product Monograph – Immucyst" 2757: 2575: 2573: 2082:-reduced) live bovine tuberculosis bacillus, 6638: 6501:(Villemin, 1868), pp. 598–631. From p. 598: 6435:Bulletin de l'AcadĂ©mie ImpĂ©riale de MĂ©decine 6433:[Cause and nature of tuberculosis]. 6200: 6198: 6160: 5975:"BCG Vaccine – Its Evolution and Importance" 5820:Hamiel U, Kozer E, Youngster I (June 2020). 5447: 4374: 4243:Liu Y, Lu J, Huang Y, Ma L (10 March 2019). 4242: 3603:: CS1 maint: DOI inactive as of June 2024 ( 3216: 3005: 2896: 2766: 2291:The BCG vaccine is very efficacious against 778:, causing either suppurative (production of 437:shows that additional doses are beneficial. 152: 7487:"Situation Report 13 April 2020 – COVID-19" 7328: 6114:. Ssi.dk. 19 September 2013. Archived from 6032:Handbook of media for clinical microbiology 6029: 5949:"Évolution du calendrier vaccinal au Maroc" 5928:South African National Department of Health 4565:MMWR. Morbidity and Mortality Weekly Report 4150:"BCG Adenitis-Need for Increased Awareness" 4105:The Cochrane Database of Systematic Reviews 3818: 3816: 3814: 3374: 3372: 2586:. World Health Organization. Archived from 2311:Tentative evidence exists for a beneficial 766:—large, raised scars. The insertion to the 699: 27:Vaccine primarily used against tuberculosis 7680: 7666: 6177:, p. 5, December 2015, archived from 5575: 5199: 4841:"Đ—Đ°ĐŽŃŠĐ»Đ¶ĐžŃ‚Đ”Đ»ĐœĐž Đž ĐżŃ€Đ”ĐżĐŸŃ€ŃŠŃ‡ĐžŃ‚Đ”Đ»ĐœĐž ĐžĐŒŃƒĐœĐžĐ·Đ°Ń†ĐžĐž" 4746: 4744: 4101:"Treating BCG-induced disease in children" 3559:The American Review of Respiratory Disease 3552: 3459: 3137: 3135: 2679: 2677: 2675: 2673: 2671: 2669: 2667: 2665: 2663: 2570: 2420:"Regulatory Decision Summary - Verity-BCG" 40: 7650:at the U.S. National Library of Medicine 7620: 7571: 7561: 7462: 7452: 7403: 7354: 7262: 7179: 7123: 7074: 7064: 7007: 6966: 6808: 6793: 6770: 6760: 6666: 6656: 6526: 6405: 6356: 6195: 5896: 5886: 5845: 5774: 5764: 5394: 5384: 4927: 4672: 4586: 4576: 4351: 4270: 4260: 4165: 4154:The Malaysian Journal of Medical Sciences 4124: 4070:"Intravesical Therapy for Bladder Cancer" 4015: 3914: 3794: 3692: 3643: 3485: 3436: 3426: 3385: 3251: 3089: 2996: 2967: 2931: 2835: 2825: 2784: 2697: 2661: 2659: 2657: 2655: 2653: 2651: 2649: 2647: 2645: 2643: 348: 341: 6996:The Pediatric Infectious Disease Journal 6552:[The etiology of tuberculosis]. 6463: 6428: 5707: 5683:"Review of mass B.C.G. project in India" 5514:"BCG tuberculosis (TB) vaccine overview" 4525: 4523: 4521: 4519: 4517: 4515: 4513: 4511: 4509: 4507: 4505: 4503: 4501: 4499: 4497: 4495: 4493: 4491: 4489: 4487: 4485: 4483: 4481: 4479: 4477: 3811: 3369: 2172: 1997:Hong Kong: BCG is given to all newborns. 703: 630: 7329:Gong W, Mao Y, Li Y, Qi Y (July 2022). 6839: 6007:. Royal Children's Hospital Melbourne. 4741: 4475: 4473: 4471: 4469: 4467: 4465: 4463: 4461: 4459: 4457: 4148:Govindarajan KK, Chai FY (April 2011). 3758:from the original on 22 September 2017. 3175: 3173: 3132: 2976: 2948: 2720: 2614:Japanese Journal of Infectious Diseases 2177:French poster promoting the BCG vaccine 305: 125: 14: 8822: 7032: 6300: 6269: 6251:from the original on 14 September 2020 5670:from the original on 19 November 2015. 5286:"Vaccinări cu obligativitate generală" 4997:dĂ©cret n° 2007-1111 du 17 juillet 2007 3063: 2640: 2242:, a veterinarian, were working at the 2181:The history of BCG is tied to that of 408:(TB). It is named after its inventors 260: 7661: 7098:Behar SM, Sassetti C (January 2020). 6900:from the original on 19 February 2014 6601: 6587: 6092:from the original on 22 February 2014 5610:from the original on 10 November 2019 5544: 5429:from the original on 19 November 2021 4908:International Journal of Epidemiology 4791:from the original on 5 September 2024 4606:from the original on 5 September 2024 4181:Malaysian Journal of Medical Sciences 3312:International Journal of Epidemiology 2962:. Geneva: World Health Organization. 2558:from the original on 24 February 2021 2524:from the original on 5 September 2024 2464:from the original on 5 September 2024 2400:from the original on 5 September 2024 416:. In countries where tuberculosis or 273: 143: 111: 7218:from the original on 16 January 2024 6796:BCG vaccination against tuberculosis 6698: 6564:from the original on 9 December 2021 6547: 6445:from the original on 9 December 2021 6313:from the original on 5 February 2016 6216:from the original on 6 February 2016 6086:"Pharmaceutical Information – PACIS" 6066:from the original on 15 January 2021 4454: 3344: 3179: 3170: 3114:"Tuberculin Skin Testing Fact Sheet" 2257:Public acceptance was slow, and the 2228:was found to be just as virulent as 1238:1961–1998 (East Germany began 1951) 208: 198: 6842:Bulletin of the History of Medicine 6431:"Cause et nature de la tuberculose" 5979:Centre for Health Solutions - Kenya 5259:. venice.cineca.org. Archived from 3903:The New England Journal of Medicine 3553:Palmer CE, Long MW (October 1966). 3120:from the original on 9 January 2017 3045:from the original on 6 January 2020 2983:"BCG Vaccine: WHO position paper". 2494:from the original on 10 August 2020 1936: 1929: 1904: 1897: 1872: 1840: 1808: 1776: 1744: 1712: 1705: 1680: 1673: 1648: 1641: 1616: 1584: 1577: 1552: 1520: 1513: 1488: 1456: 1449: 1424: 1417: 1392: 1385: 1326: 1294: 1287: 1262: 1230: 1198: 1166: 1134: 1127: 1102: 1070: 1038: 1031: 1006: 999: 974: 967: 908: 375: 368: 24: 8855:Drugs developed by Merck & Co. 8850:Drugs developed by Schering-Plough 8740:Eradication of infectious diseases 8497:Androvax (androstenedione albumin) 7533:from the original on 1 March 2021. 7503:from the original on 13 April 2020 6955:The Journal of Infectious Diseases 6821:from the original on 26 April 2021 5640:from the original on 16 April 2017 5348:from the original on 13 April 2020 5242:from the original on 7 March 2016. 5145:from the original on 11 April 2020 4970:from the original on 23 April 2020 4080:from the original on 30 March 2020 2810:"Immunotherapy for bladder cancer" 2343: 2132: 1968: 1961: 1865: 1833: 1801: 1769: 1737: 1609: 1545: 1481: 1358: 1351: 1319: 1255: 1223: 1191: 1159: 1095: 1063: 940: 933: 901: 757: 731:injection at the insertion of the 550:Genetic variation in BCG strains: 25: 8871: 8330:Respiratory syncytial virus (RSV) 7641: 6930:from the original on 27 June 2024 6798:. Boston: Little, Brown & Co. 6723:from the original on 25 July 2024 6645:Veterinary Medicine International 6639:Palmer MV, Waters WR (May 2011). 6618:from the original on 25 July 2024 6478:from the original on 25 July 2024 6282:from the original on 12 July 2020 6210:U.S. Food and Drug Administration 6011:from the original on 9 March 2020 5985:from the original on 25 July 2024 5681:Mahler HT, Mohamed Ali P (1955). 5557:from the original on 25 July 2024 5526:from the original on 1 April 2016 5494:from the original on 6 March 2012 5484:"School "TB jabs" to be scrapped" 5212:from the original on 7 April 2020 5181:from the original on 16 July 2019 5020:from the original on 30 July 2012 4729:from the original on 25 July 2024 4537:from the original on 12 June 2009 4050:from the original on 25 July 2024 3864:Biomedicine & Pharmacotherapy 3585:from the original on 25 July 2024 3460:Packe GE, Innes JA (March 1988). 3357:from the original on 24 June 2021 3024:MMWR. Recommendations and Reports 2767:Luca S, Mihaescu T (March 2013). 818:severe combined immune deficiency 235: 8807: 8719:Alternative vaccination schedule 7689:Artificial induction of immunity 7588: 7537: 7515: 7479: 7420: 7371: 7335:International Immunopharmacology 7322: 7279: 7230: 7204: 7148: 7091: 6983: 6942: 6912: 6868: 6833: 6802: 6787: 6736: 6692: 6632: 6581: 6554:Berliner Klinische Wochenschrift 6541: 6520: 6495: 6457: 6422: 6373: 6227: 6130: 6104: 5165:"IntegrĂĄlt JogvĂ©delmi SzolgĂĄlat" 3466:Archives of Disease in Childhood 3156:10.1001/jama.1994.03510330076038 2874:10.1111/j.1464-410X.2012.11390.x 2452:"Verity-BCG Product information" 2432:from the original on 5 June 2022 2394:Therapeutic Goods Administration 2060: 2020:Expanded Program on Immunization 1969: 1962: 1950: 1937: 1930: 1918: 1905: 1898: 1886: 1873: 1866: 1854: 1841: 1834: 1822: 1809: 1802: 1790: 1777: 1770: 1758: 1745: 1738: 1726: 1713: 1706: 1694: 1681: 1674: 1662: 1649: 1642: 1630: 1617: 1610: 1598: 1585: 1578: 1566: 1553: 1546: 1534: 1521: 1514: 1502: 1489: 1482: 1470: 1457: 1450: 1438: 1425: 1418: 1406: 1393: 1386: 1374: 1359: 1352: 1340: 1327: 1320: 1308: 1295: 1288: 1276: 1263: 1256: 1244: 1231: 1224: 1212: 1199: 1192: 1180: 1167: 1160: 1148: 1135: 1128: 1116: 1103: 1096: 1084: 1071: 1064: 1052: 1039: 1032: 1020: 1007: 1000: 988: 975: 968: 956: 941: 934: 922: 909: 902: 890: 790:. For nonresolving suppuration, 6550:"Die Aetologie der Tuberculose" 6148:from the original on 2 May 2024 6078: 6052: 6023: 5997: 5967: 5955:from the original on 6 May 2020 5941: 5913: 5862: 5813: 5791: 5732: 5720:from the original on 6 May 2020 5708:Chaudhry A (24 February 2015). 5701: 5674: 5652: 5622: 5596: 5569: 5538: 5506: 5476: 5441: 5411: 5360: 5330: 5318:from the original on 6 May 2020 5304: 5278: 5246: 5224: 5193: 5157: 5127: 5115:from the original on 8 May 2021 5097: 5062: 5032: 5000: 4991: 4982: 4952: 4895: 4883:from the original on 6 May 2020 4863: 4833: 4821:from the original on 6 May 2020 4803: 4715: 4689: 4648: 4636:from the original on 6 May 2020 4618: 4549: 4411: 4368: 4331: 4287: 4236: 4202:Scandinavian Journal of Urology 4192: 4141: 4092: 4062: 4032: 3931: 3890: 3787:10.1128/IAI.69.9.5403-5411.2001 3762: 3709: 3660: 3611: 3546: 3502: 3453: 3394: 3338: 3303: 3268: 3106: 3057: 2852: 2814:Research and Reports in Urology 2801: 2714: 2190:unidentified microorganism (or 1560:1947–1995, voluntary 1995–2009 735:. If BCG is accidentally given 591: 473: 468: 8551:Ovandrotone albumin (Fecundin) 6513:maladies , ... ) From p. 602: 6270:Palmer E (10 September 2014). 5172:IntegrĂĄlt JogvĂ©delmi SzolgĂĄlat 4117:10.1002/14651858.CD008300.pub2 3070:Paediatrics & Child Health 2605: 2536: 2506: 2476: 2444: 2412: 2382: 2073: 2030: 509:interferon gamma release assay 248: 13: 1: 8082:Group B streptococcal disease 7901:Vaccines for Children Program 7300:10.1080/14760584.2017.1333906 6717:10.1016/S0140-6736(01)85122-9 6349:10.1016/j.vaccine.2017.12.010 5875:Italian Journal of Pediatrics 5766:10.1016/j.heliyon.2020.e04898 5630:"ç”æ žăšBCGăƒŻă‚Żăƒăƒłă«é–ąă™ă‚‹Q&AïœœćŽšç”ŸćŠŽćƒçœ" 5604:"Child health – Immunisation" 4988:Loi n° 50-7 du 5 janvier 1950 4674:10.1016/j.vaccine.2017.06.064 4432:10.1016/S0140-6736(08)61318-5 4389:10.1016/S0140-6736(06)68507-3 4340:Weekly Epidemiological Record 4309:10.1016/j.urolonc.2020.11.037 4214:10.1080/21681805.2019.1609080 3996:Clinical Microbiology Reviews 3741:10.1016/j.vaccine.2005.01.069 3636:10.1128/IAI.70.2.672-678.2002 3524:10.1016/S0140-6736(02)08353-8 3244:10.1016/j.vaccine.2011.12.044 3194:10.1016/S0140-6736(95)92348-9 2985:Weekly Epidemiological Record 2686:Weekly Epidemiological Record 2375: 7613:10.1016/j.eclinm.2022.101414 7454:10.1371/journal.pone.0240203 7347:10.1016/j.intimp.2022.108870 7009:10.1097/inf.0b013e3182458289 6809:Blackburn M (24 July 2013). 6060:"Onko BCG 100 Biomed Lublin" 6030:Atlas RM, Snyder JW (2006). 5462:10.1016/0041-3879(76)90015-5 5386:10.1371/journal.pmed.1001012 3876:10.1016/j.biopha.2007.05.004 3838:10.1016/j.eururo.2014.02.061 2723:Journal of Medical Biography 2550:Food and Drug Administration 2370:randomized controlled trials 2194:, as he called it). In 1882 884:Years vaccine was mandatory 574:Mycobacterium intracellulare 427:nontuberculous mycobacterial 97:BCG Vaccine, BCG Vaccine AJV 7: 7166:(7789): 145. January 2020. 5693:(3): 108–16. Archived from 4964:BCG- eli tuberkuloosirokote 3916:10.1056/NEJM199110243251703 2991:(79): 27–38. January 2004. 2626:10.7883/yoken.JJID.2007.331 2355: 2306: 2212:. Following the success of 1938: 1931: 1906: 1899: 1874: 1842: 1810: 1778: 1746: 1714: 1707: 1682: 1675: 1650: 1643: 1618: 1586: 1579: 1554: 1522: 1515: 1490: 1458: 1451: 1426: 1419: 1394: 1387: 1328: 1296: 1289: 1264: 1232: 1200: 1168: 1136: 1129: 1104: 1072: 1040: 1033: 1008: 1001: 976: 969: 910: 836: 540: 10: 8876: 7563:10.1016/j.xcrm.2022.100728 7396:10.1016/j.xcrm.2022.100728 7181:10.1038/d41586-020-00003-w 7125:10.1038/d41586-019-03597-y 6762:10.1186/s13620-023-00257-6 6301:Palmer E (31 March 2015), 5545:McKie R (9 January 2022). 3571:10.1164/arrd.1966.94.4.553 3345:Kupz A (14 January 2021). 2972:. WHO/MHP/HPS/EML/2023.02. 2274:Fort Qu'Appelle Sanatorium 2209:Mycobacterium tuberculosis 2168: 2114:PowderJect Pharmaceuticals 2100:, and in turn acquired by 1970: 1963: 1867: 1835: 1803: 1771: 1739: 1611: 1547: 1483: 1360: 1353: 1321: 1257: 1225: 1193: 1161: 1097: 1065: 942: 935: 903: 724:receptor pathway defects. 616: 477: 68:Mycobacterium tuberculosis 8758: 8727: 8666: 8598: 8489: 8461: 8428: 8097: 7928: 7921: 7840: 7768: 7720: 7494:World Health Organisation 7288:Expert Review of Vaccines 7255:10.1038/s41541-018-0062-8 7066:10.1038/s41586-019-1817-8 6467:Études sur la Tuberculose 3944:Expert Review of Vaccines 3573:(inactive 27 June 2024). 2956:World Health Organization 2286:World Health Organization 2244:Institut Pasteur de Lille 2044: 864: 751:, which it may resemble. 727:BCG is given as a single 687:. The US biotech company 610: 535:World Health Organization 359: 332: 316: 296: 291: 225: 220: 185: 163: 133: 119: 101: 91: 86: 74: 62: 55: 39: 8077:Clostridioides difficile 7652:Medical Subject Headings 6749:Irish Veterinary Journal 6548:Koch R (10 April 1882). 5799:"Role of BC Vaccination" 3956:10.1586/14760584.4.3.329 3289:10.1001/jama.291.17.2086 2769:"History of BCG Vaccine" 2735:10.1258/j.jmb.2007.06-15 2155: 827: 700:Method of administration 531:Tuberculosis elimination 390:Bacillus Calmette–GuĂ©rin 50:, magnification: 1,000nn 18:Bacillus Calmette-GuĂ©rin 8340:Tick-borne encephalitis 6699:Koch R (27 July 1901). 6472:Studies of Tuberculosis 6398:10.1136/bmj.2.5312.1086 6386:British Medical Journal 5888:10.1186/1824-7288-35-42 5578:Chinese Medical Journal 5342:folkhalsomyndigheten.se 4723:"Esquema de VacunaciĂłn" 4533:. The BCG World Atlas. 3428:10.1073/pnas.0700869104 3064:Vaudry W (March 2003). 1984: 797:Uncommonly, breast and 404:primarily used against 256: / Schedule D 113:Professional Drug Facts 8750:List of vaccine topics 7745:Mathematical modelling 7550:Cell Reports. Medicine 7384:Cell Reports. Medicine 6175:UNICEF Supply Division 5930:. 2006. Archived from 5838:10.1001/jama.2020.8189 4871:"Kopie – cem05_14.p65" 4781:"Tuberculosis Vaccine" 4578:10.15585/mmwr.mm7243a1 3775:Infection and Immunity 3624:Infection and Immunity 2293:tuberculous meningitis 2178: 2160:Some BCG vaccines are 2118:Statens Serum Institut 964:Bosnia and Herzegovina 881:Mandatory in the past 870:BCG vaccine in Europe 709: 653: 8845:Tuberculosis vaccines 8745:Vaccinate Your Family 8196:Japanese encephalitis 6968:10.1093/infdis/jir240 6854:10.1353/bhm.2007.0022 6794:Rosenthal SR (1957). 6527:Villemin JA (1868a). 6242:Sanofi Pasteur Canada 5083:10.5588/ijtld.14.0282 4186:26 March 2012 at the 3324:10.1093/ije/22.6.1154 2187:Jean Antoine Villemin 2176: 782:) and nonsuppurative 707: 673:used in the treatment 634: 570:Mycobacterium marinum 480:Tuberculosis vaccines 8628:John Franklin Enders 6464:Villemin JA (1868). 6429:Villemin JA (1865). 6062:. biomedlublin.com. 6005:"BCG vaccine for TB" 5697:on 13 February 2007. 5344:. 21 February 2022. 4697:"Ficha metodolĂłgica" 4262:10.1155/2019/6230409 4008:10.1128/CMR.00100-19 3735:(17–18): 2115–2120. 3478:10.1136/adc.63.3.277 3390:. WHO/V&B/99.23. 2554:. 21 February 2018. 2520:. 3 September 2020. 2335:University of Oxford 2284:(predecessor to the 749:smallpox vaccination 714:tuberculin skin test 619:Cancer immunotherapy 520:miliary tuberculosis 425:infection and other 7809:Virus-like particle 7733:Vaccine ingredients 7527:Clinical Trials.gov 7445:2020PLoSO..1540203S 7214:. 15 January 2024. 7172:2020Natur.577..145. 7116:2020Natur.577...31B 7057:2020Natur.577...95D 6658:10.4061/2011/816345 6392:(5312): 1086–1089. 6118:on 18 February 2014 5981:. 12 January 2016. 5757:2020Heliy...604898R 4383:(9517): 1173–1180. 4249:Journal of Oncology 3673:Parasite Immunology 3518:(9315): 1393–1401. 3419:2007PNAS..104.5596B 3188:(8986): 1339–1345. 3082:10.1093/pch/8.3.141 2428:. 23 October 2014. 2313:non-specific effect 2278:residential schools 2204:Mycobacterium bovis 2085:Mycobacterium bovis 871: 858:latent tuberculosis 566:Mycobacterium avium 451:Mycobacterium bovis 269:(Prescription only) 244:(Prescription only) 57:Vaccine description 48:Ziehl–Neelsen stain 36: 8785:Never to phase III 8584:Hexavalent vaccine 8398:Epstein–Barr virus 8293:Oxford–AstraZeneca 7981:NmVac4-A/C/Y/W-135 6924:Techno-Science.net 6184:on 5 February 2016 6138:"The Story of SSI" 5687:Ind J Tuberculosis 4920:10.1093/ije/dyw120 3716:Rook GA, Dheda K, 2827:10.2147/RRU.S63447 2593:on 19 October 2021 2296:having a reliable 2179: 869: 710: 654: 32: 8795: 8794: 8707:Vaccines and SIDS 8594: 8593: 8368:Hepatitis A and B 8344:Varicella zoster 7801:Subunit/component 7601:eClinicalMedicine 7496:. 13 April 2020. 6890:978-90-5549-844-4 6711:(4065): 187–191. 6045:978-0-8493-3795-6 5832:(22): 2340–2341. 5660:"Thai Pediatrics" 5423:ips.ligazakon.net 5292:on 19 August 2013 4785:Tuberculosis (TB) 4756:Tuberculosis (TB) 4667:(36): 4777–4784. 4571:(43): 1155–1161. 4426:(9641): 786–787. 4297:Urologic Oncology 3909:(17): 1205–1209. 3685:10.1111/pim.12939 3413:(13): 5596–5601. 3283:(17): 2086–2091. 2924:10.1136/bmj.g4643 2862:BJU International 2460:. 25 April 2012. 2282:League of Nations 2272:, working at the 2252:Pasteur Institute 1982: 1981: 1978: 1368: 950: 792:surgical excision 788:needle aspiration 685:colorectal cancer 552:Genetic variation 533:is a goal of the 446:immunosuppression 386: 385: 277: 264: 251: 239: 146: 16:(Redirected from 8867: 8812: 8811: 8810: 8803: 8686:MMR autism fraud 8633:Maurice Hilleman 8618:Hilary Koprowski 7926: 7925: 7682: 7675: 7668: 7659: 7658: 7635: 7634: 7624: 7592: 7586: 7585: 7575: 7565: 7541: 7535: 7534: 7519: 7513: 7512: 7510: 7508: 7502: 7491: 7483: 7477: 7476: 7466: 7456: 7439:(10): e0240203. 7424: 7418: 7417: 7407: 7375: 7369: 7368: 7358: 7326: 7320: 7319: 7283: 7277: 7276: 7266: 7234: 7228: 7227: 7225: 7223: 7208: 7202: 7201: 7183: 7152: 7146: 7145: 7127: 7095: 7089: 7088: 7078: 7068: 7051:(7788): 95–102. 7036: 7030: 7029: 7011: 6987: 6981: 6980: 6970: 6946: 6940: 6939: 6937: 6935: 6916: 6910: 6909: 6907: 6905: 6899: 6882: 6872: 6866: 6865: 6837: 6831: 6830: 6828: 6826: 6806: 6800: 6799: 6791: 6785: 6784: 6774: 6764: 6740: 6734: 6732: 6730: 6728: 6696: 6690: 6688: 6670: 6660: 6636: 6630: 6627: 6625: 6623: 6602:Smith T (1896). 6597: 6588:Smith T (1895). 6585: 6579: 6573: 6571: 6569: 6545: 6539: 6538: 6524: 6518: 6499: 6493: 6487: 6485: 6483: 6461: 6455: 6454: 6452: 6450: 6426: 6420: 6419: 6409: 6377: 6371: 6370: 6360: 6328: 6322: 6321: 6320: 6318: 6298: 6292: 6291: 6289: 6287: 6267: 6261: 6260: 6258: 6256: 6250: 6239: 6231: 6225: 6224: 6223: 6221: 6202: 6193: 6192: 6191: 6189: 6183: 6172: 6164: 6158: 6157: 6155: 6153: 6134: 6128: 6127: 6125: 6123: 6108: 6102: 6101: 6099: 6097: 6082: 6076: 6075: 6073: 6071: 6056: 6050: 6049: 6027: 6021: 6020: 6018: 6016: 6001: 5995: 5994: 5992: 5990: 5971: 5965: 5964: 5962: 5960: 5945: 5939: 5938: 5936: 5925: 5917: 5911: 5910: 5900: 5890: 5866: 5860: 5859: 5849: 5817: 5811: 5810: 5805:. Archived from 5795: 5789: 5788: 5778: 5768: 5736: 5730: 5729: 5727: 5725: 5705: 5699: 5698: 5678: 5672: 5671: 5656: 5650: 5649: 5647: 5645: 5626: 5620: 5619: 5617: 5615: 5600: 5594: 5593: 5573: 5567: 5566: 5564: 5562: 5542: 5536: 5535: 5533: 5531: 5510: 5504: 5503: 5501: 5499: 5480: 5474: 5473: 5445: 5439: 5438: 5436: 5434: 5415: 5409: 5408: 5398: 5388: 5364: 5358: 5357: 5355: 5353: 5334: 5328: 5327: 5325: 5323: 5308: 5302: 5301: 5299: 5297: 5282: 5276: 5275: 5273: 5271: 5265: 5258: 5250: 5244: 5243: 5238:(in Norwegian). 5228: 5222: 5221: 5219: 5217: 5197: 5191: 5190: 5188: 5186: 5180: 5174:(in Hungarian). 5169: 5161: 5155: 5154: 5152: 5150: 5141:. 17 July 2015. 5131: 5125: 5124: 5122: 5120: 5109:Î„Ï€ÎżÏ…ÏÎłÎ”ÎŻÎż Î„ÎłÎ”ÎŻÎ±Ï‚ 5101: 5095: 5094: 5066: 5060: 5059: 5057: 5055: 5046:. Archived from 5036: 5030: 5029: 5027: 5025: 5019: 5012: 5004: 4998: 4995: 4989: 4986: 4980: 4979: 4977: 4975: 4956: 4950: 4949: 4931: 4899: 4893: 4892: 4890: 4888: 4882: 4875: 4867: 4861: 4860: 4858: 4856: 4851:on 11 April 2020 4847:. Archived from 4845:mh.government.bg 4837: 4831: 4830: 4828: 4826: 4807: 4801: 4800: 4798: 4796: 4787:. 11 July 2024. 4777: 4768: 4767: 4765: 4763: 4748: 4739: 4738: 4736: 4734: 4719: 4713: 4712: 4710: 4708: 4699:. Archived from 4693: 4687: 4686: 4676: 4652: 4646: 4645: 4643: 4641: 4632:. January 2020. 4622: 4616: 4615: 4613: 4611: 4605: 4590: 4580: 4562: 4553: 4547: 4546: 4544: 4542: 4527: 4452: 4451: 4415: 4409: 4408: 4372: 4366: 4365: 4355: 4335: 4329: 4328: 4291: 4285: 4284: 4274: 4264: 4240: 4234: 4233: 4208:(2–3): 116–122. 4196: 4190: 4179: 4169: 4145: 4139: 4138: 4128: 4096: 4090: 4089: 4087: 4085: 4066: 4060: 4059: 4057: 4055: 4036: 4030: 4029: 4019: 3987: 3976: 3975: 3935: 3929: 3928: 3918: 3894: 3888: 3887: 3859: 3850: 3849: 3826:European Urology 3820: 3809: 3808: 3798: 3781:(9): 5403–5411. 3766: 3760: 3759: 3757: 3726: 3713: 3707: 3706: 3696: 3664: 3658: 3657: 3647: 3615: 3609: 3608: 3602: 3594: 3592: 3590: 3550: 3544: 3543: 3506: 3500: 3499: 3489: 3457: 3451: 3450: 3440: 3430: 3398: 3392: 3391: 3389: 3376: 3367: 3366: 3364: 3362: 3351:The Conversation 3342: 3336: 3335: 3318:(6): 1154–1158. 3307: 3301: 3300: 3272: 3266: 3265: 3255: 3238:(6): 1038–1049. 3223: 3214: 3213: 3177: 3168: 3167: 3139: 3130: 3129: 3127: 3125: 3116:. 12 July 2023. 3110: 3104: 3103: 3093: 3061: 3055: 3054: 3052: 3050: 3044: 3021: 3012: 3003: 3002: 3000: 2980: 2974: 2973: 2971: 2952: 2946: 2945: 2935: 2903: 2894: 2893: 2856: 2850: 2849: 2839: 2829: 2805: 2799: 2798: 2788: 2764: 2755: 2754: 2718: 2712: 2711: 2701: 2681: 2638: 2637: 2609: 2603: 2602: 2600: 2598: 2592: 2585: 2577: 2568: 2567: 2565: 2563: 2540: 2534: 2533: 2531: 2529: 2510: 2504: 2503: 2501: 2499: 2480: 2474: 2473: 2471: 2469: 2448: 2442: 2441: 2439: 2437: 2416: 2410: 2409: 2407: 2405: 2386: 2338:Jenner Institute 1976: 1973: 1972: 1966: 1965: 1955: 1954: 1953: 1941: 1940: 1934: 1933: 1923: 1922: 1921: 1909: 1908: 1902: 1901: 1891: 1890: 1889: 1877: 1876: 1870: 1869: 1859: 1858: 1857: 1845: 1844: 1838: 1837: 1827: 1826: 1825: 1813: 1812: 1806: 1805: 1795: 1794: 1793: 1781: 1780: 1774: 1773: 1763: 1762: 1761: 1749: 1748: 1742: 1741: 1731: 1730: 1729: 1717: 1716: 1710: 1709: 1699: 1698: 1697: 1685: 1684: 1678: 1677: 1667: 1666: 1665: 1653: 1652: 1646: 1645: 1635: 1634: 1633: 1621: 1620: 1614: 1613: 1603: 1602: 1601: 1589: 1588: 1582: 1581: 1571: 1570: 1569: 1557: 1556: 1550: 1549: 1539: 1538: 1537: 1525: 1524: 1518: 1517: 1507: 1506: 1505: 1493: 1492: 1486: 1485: 1475: 1474: 1473: 1461: 1460: 1454: 1453: 1443: 1442: 1441: 1429: 1428: 1422: 1421: 1411: 1410: 1409: 1397: 1396: 1390: 1389: 1379: 1378: 1377: 1366: 1363: 1362: 1356: 1355: 1345: 1344: 1343: 1331: 1330: 1324: 1323: 1313: 1312: 1311: 1299: 1298: 1292: 1291: 1281: 1280: 1279: 1267: 1266: 1260: 1259: 1249: 1248: 1247: 1235: 1234: 1228: 1227: 1217: 1216: 1215: 1203: 1202: 1196: 1195: 1185: 1184: 1183: 1171: 1170: 1164: 1163: 1153: 1152: 1151: 1139: 1138: 1132: 1131: 1121: 1120: 1119: 1107: 1106: 1100: 1099: 1089: 1088: 1087: 1075: 1074: 1068: 1067: 1057: 1056: 1055: 1043: 1042: 1036: 1035: 1025: 1024: 1023: 1011: 1010: 1004: 1003: 993: 992: 991: 979: 978: 972: 971: 961: 960: 959: 948: 945: 944: 938: 937: 927: 926: 925: 913: 912: 906: 905: 895: 894: 893: 872: 868: 712:A pre-injection 379: 372: 352: 345: 309: 275: 272: 262: 259: 250: 247: 237: 234: 212: 202: 156: 145: 142: 129: 115: 44: 37: 35: 31: 21: 8875: 8874: 8870: 8869: 8868: 8866: 8865: 8864: 8835:Cancer vaccines 8820: 8819: 8818: 8808: 8806: 8798: 8796: 8791: 8790: 8775:Clinical trials 8754: 8723: 8662: 8638:Stanley Plotkin 8600: 8590: 8502:Cancer vaccines 8485: 8479:Schistosomiasis 8457: 8451:Trypanosomiasis 8424: 8388:Cytomegalovirus 8298:Pfizer–BioNTech 8093: 7917: 7866:Vaccine wastage 7836: 7764: 7716: 7686: 7644: 7639: 7638: 7593: 7589: 7542: 7538: 7521: 7520: 7516: 7506: 7504: 7500: 7489: 7485: 7484: 7480: 7425: 7421: 7376: 7372: 7341:(108): 108870. 7327: 7323: 7284: 7280: 7235: 7231: 7221: 7219: 7210: 7209: 7205: 7154: 7153: 7149: 7110:(7788): 31–32. 7096: 7092: 7037: 7033: 6988: 6984: 6947: 6943: 6933: 6931: 6918: 6917: 6913: 6903: 6901: 6897: 6891: 6880: 6874: 6873: 6869: 6838: 6834: 6824: 6822: 6807: 6803: 6792: 6788: 6755:(Suppl 1): 26. 6741: 6737: 6726: 6724: 6697: 6693: 6637: 6633: 6621: 6619: 6586: 6582: 6567: 6565: 6560:(15): 221–230. 6546: 6542: 6525: 6521: 6500: 6496: 6481: 6479: 6462: 6458: 6448: 6446: 6427: 6423: 6378: 6374: 6329: 6325: 6316: 6314: 6299: 6295: 6285: 6283: 6268: 6264: 6254: 6252: 6248: 6237: 6233: 6232: 6228: 6219: 6217: 6204: 6203: 6196: 6187: 6185: 6181: 6170: 6166: 6165: 6161: 6151: 6149: 6136: 6135: 6131: 6121: 6119: 6110: 6109: 6105: 6095: 6093: 6084: 6083: 6079: 6069: 6067: 6058: 6057: 6053: 6046: 6028: 6024: 6014: 6012: 6003: 6002: 5998: 5988: 5986: 5973: 5972: 5968: 5958: 5956: 5951:. 29 May 2006. 5947: 5946: 5942: 5937:on 11 May 2013. 5934: 5923: 5919: 5918: 5914: 5867: 5863: 5818: 5814: 5809:on 6 June 2013. 5797: 5796: 5792: 5737: 5733: 5723: 5721: 5706: 5702: 5679: 5675: 5664:Thai Pediatrics 5658: 5657: 5653: 5643: 5641: 5636:(in Japanese). 5628: 5627: 5623: 5613: 5611: 5602: 5601: 5597: 5574: 5570: 5560: 5558: 5543: 5539: 5529: 5527: 5512: 5511: 5507: 5497: 5495: 5490:. 6 July 2005. 5488:BBC News Online 5482: 5481: 5477: 5446: 5442: 5432: 5430: 5417: 5416: 5412: 5379:(3): e1001012. 5365: 5361: 5351: 5349: 5336: 5335: 5331: 5321: 5319: 5310: 5309: 5305: 5295: 5293: 5284: 5283: 5279: 5269: 5267: 5266:on 7 April 2020 5263: 5256: 5254:"Portugal data" 5252: 5251: 5247: 5230: 5229: 5225: 5215: 5213: 5206:The Irish Times 5198: 5194: 5184: 5182: 5178: 5167: 5163: 5162: 5158: 5148: 5146: 5133: 5132: 5128: 5118: 5116: 5103: 5102: 5098: 5067: 5063: 5053: 5051: 5050:on 12 June 2009 5044:BCG World Atlas 5038: 5037: 5033: 5023: 5021: 5017: 5010: 5006: 5005: 5001: 4996: 4992: 4987: 4983: 4973: 4971: 4958: 4957: 4953: 4900: 4896: 4886: 4884: 4880: 4873: 4869: 4868: 4864: 4854: 4852: 4839: 4838: 4834: 4824: 4822: 4809: 4808: 4804: 4794: 4792: 4779: 4778: 4771: 4761: 4759: 4750: 4749: 4742: 4732: 4730: 4721: 4720: 4716: 4706: 4704: 4703:on 2 April 2015 4695: 4694: 4690: 4653: 4649: 4639: 4637: 4624: 4623: 4619: 4609: 4607: 4603: 4560: 4554: 4550: 4540: 4538: 4529: 4528: 4455: 4416: 4412: 4373: 4369: 4346:(21): 193–196. 4336: 4332: 4292: 4288: 4241: 4237: 4197: 4193: 4188:Wayback Machine 4146: 4142: 4111:(1): CD008300. 4097: 4093: 4083: 4081: 4068: 4067: 4063: 4053: 4051: 4038: 4037: 4033: 3988: 3979: 3936: 3932: 3895: 3891: 3860: 3853: 3821: 3812: 3767: 3763: 3755: 3724: 3714: 3710: 3665: 3661: 3616: 3612: 3596: 3595: 3588: 3586: 3551: 3547: 3507: 3503: 3458: 3454: 3399: 3395: 3377: 3370: 3360: 3358: 3343: 3339: 3308: 3304: 3273: 3269: 3224: 3217: 3178: 3171: 3140: 3133: 3123: 3121: 3112: 3111: 3107: 3062: 3058: 3048: 3046: 3042: 3019: 3013: 3006: 2982: 2981: 2977: 2953: 2949: 2904: 2897: 2857: 2853: 2806: 2802: 2765: 2758: 2719: 2715: 2682: 2641: 2610: 2606: 2596: 2594: 2590: 2583: 2579: 2578: 2571: 2561: 2559: 2542: 2541: 2537: 2527: 2525: 2512: 2511: 2507: 2497: 2495: 2482: 2481: 2477: 2467: 2465: 2450: 2449: 2445: 2435: 2433: 2418: 2417: 2413: 2403: 2401: 2388: 2387: 2383: 2378: 2358: 2350:type 1 diabetes 2346: 2344:Type 1 diabetes 2324:rhesus macaques 2309: 2259:LĂŒbeck disaster 2236:Albert Calmette 2230:M. tuberculosis 2171: 2158: 2135: 2133:Supply shortage 2124:According to a 2102:Merck & Co. 2098:Schering-Plough 2090:Middlebrook 7H9 2076: 2063: 2047: 2033: 1987: 1951: 1949: 1919: 1917: 1887: 1885: 1855: 1853: 1823: 1821: 1791: 1789: 1759: 1757: 1727: 1725: 1695: 1693: 1663: 1661: 1631: 1629: 1599: 1597: 1567: 1565: 1535: 1533: 1510:North Macedonia 1503: 1501: 1471: 1469: 1439: 1437: 1407: 1405: 1375: 1373: 1341: 1339: 1309: 1307: 1277: 1275: 1245: 1243: 1213: 1211: 1181: 1179: 1149: 1147: 1117: 1115: 1085: 1083: 1053: 1051: 1021: 1019: 989: 987: 957: 955: 923: 921: 891: 889: 867: 839: 830: 760: 758:Adverse effects 702: 666:cancer vaccines 629: 613: 594: 543: 482: 476: 471: 410:Albert Calmette 382: 355: 328: 312: 287: 216: 166: 159: 51: 28: 23: 22: 15: 12: 11: 5: 8873: 8863: 8862: 8857: 8852: 8847: 8842: 8837: 8832: 8817: 8816: 8793: 8792: 8789: 8788: 8787: 8786: 8783: 8772: 8766: 8760: 8759: 8756: 8755: 8753: 8752: 8747: 8742: 8737: 8731: 8729: 8725: 8724: 8722: 8721: 8716: 8709: 8704: 8699: 8694: 8689: 8676: 8670: 8668: 8664: 8663: 8661: 8660: 8655: 8653:Katalin KarikĂł 8650: 8645: 8640: 8635: 8630: 8625: 8620: 8615: 8610: 8604: 8602: 8596: 8595: 8592: 8591: 8589: 8588: 8587: 8586: 8581: 8576: 8571: 8563: 8558: 8553: 8548: 8543: 8542: 8541: 8536: 8535: 8534: 8529: 8519: 8514: 8509: 8499: 8493: 8491: 8487: 8486: 8484: 8483: 8482: 8481: 8476: 8467: 8465: 8459: 8458: 8456: 8455: 8454: 8453: 8445: 8444: 8443: 8432: 8430: 8426: 8425: 8423: 8422: 8421: 8420: 8415: 8410: 8408:Herpes simplex 8405: 8400: 8395: 8390: 8382: 8381: 8380: 8375: 8370: 8362: 8357: 8356: 8355: 8350: 8342: 8337: 8332: 8327: 8326: 8325: 8320: 8315: 8310: 8308:Sinopharm BIBP 8305: 8300: 8295: 8290: 8285: 8280: 8275: 8270: 8265: 8260: 8258:Bharat Biotech 8255: 8245: 8240: 8235: 8230: 8229: 8228: 8223: 8213: 8208: 8203: 8198: 8193: 8192: 8191: 8186: 8176: 8171: 8166: 8161: 8156: 8155: 8154: 8149: 8144: 8139: 8124: 8123: 8122: 8112: 8107: 8101: 8099: 8095: 8094: 8092: 8091: 8090: 8089: 8084: 8079: 8071: 8070: 8069: 8064: 8056: 8051: 8050: 8049: 8044: 8034: 8033: 8032: 8022: 8017: 8012: 8011: 8010: 8005: 7995: 7990: 7985: 7984: 7983: 7978: 7968: 7963: 7958: 7953: 7948: 7943: 7938: 7932: 7930: 7923: 7919: 7918: 7916: 7915: 7914: 7913: 7908: 7903: 7898: 7893: 7885: 7884: 7883: 7881:Vaccine injury 7878: 7873: 7868: 7863: 7858: 7853: 7844: 7842: 7841:Administration 7838: 7837: 7835: 7834: 7829: 7824: 7815: 7798: 7797: 7796: 7791: 7783: 7778: 7772: 7770: 7766: 7765: 7763: 7762: 7757: 7752: 7747: 7742: 7741: 7740: 7730: 7724: 7722: 7718: 7717: 7685: 7684: 7677: 7670: 7662: 7656: 7655: 7643: 7642:External links 7640: 7637: 7636: 7587: 7536: 7514: 7478: 7419: 7370: 7321: 7294:(7): 699–708. 7278: 7229: 7203: 7147: 7090: 7031: 7002:(3): 306–308. 6982: 6961:(2): 245–252. 6941: 6911: 6889: 6867: 6848:(2): 407–430. 6832: 6801: 6786: 6735: 6691: 6631: 6629: 6628: 6580: 6540: 6519: 6494: 6456: 6421: 6372: 6343:(4): 498–506. 6323: 6293: 6262: 6226: 6194: 6159: 6129: 6103: 6077: 6051: 6044: 6022: 5996: 5966: 5940: 5912: 5861: 5812: 5790: 5731: 5700: 5673: 5651: 5621: 5595: 5584:(6): 437–442. 5568: 5537: 5505: 5475: 5440: 5410: 5359: 5329: 5303: 5277: 5245: 5223: 5200:O'Sullivan K. 5192: 5156: 5126: 5096: 5061: 5031: 4999: 4990: 4981: 4951: 4914:(2): 695–705. 4894: 4862: 4832: 4802: 4769: 4758:. 11 July 2024 4740: 4714: 4688: 4647: 4617: 4548: 4453: 4410: 4367: 4330: 4286: 4235: 4191: 4140: 4091: 4074:www.cancer.org 4061: 4031: 3977: 3950:(3): 329–350. 3930: 3889: 3870:(6): 299–305. 3851: 3832:(4): 677–688. 3810: 3761: 3720:(March 2005). 3708: 3659: 3630:(2): 672–678. 3610: 3565:(4): 553–568. 3545: 3501: 3472:(3): 277–281. 3452: 3393: 3368: 3337: 3302: 3267: 3215: 3169: 3150:(9): 698–702. 3131: 3105: 3076:(3): 141–144. 3056: 3030:(RR-4): 1–18. 3004: 2975: 2947: 2895: 2868:(6): 977–983. 2851: 2800: 2756: 2729:(3): 139–146. 2713: 2639: 2620:(6): 331–336. 2604: 2569: 2535: 2505: 2475: 2443: 2411: 2380: 2379: 2377: 2374: 2357: 2354: 2345: 2342: 2308: 2305: 2270:R. G. Ferguson 2240:Camille GuĂ©rin 2200:Theobald Smith 2170: 2167: 2157: 2154: 2139:Sanofi Pasteur 2134: 2131: 2075: 2072: 2071: 2070: 2067: 2062: 2059: 2058: 2057: 2054: 2051: 2046: 2043: 2042: 2041: 2037: 2032: 2029: 2028: 2027: 2023: 2016: 2013: 2009: 2006: 1998: 1995: 1991: 1986: 1983: 1980: 1979: 1974: 1967: 1960: 1958:United Kingdom 1946: 1945: 1942: 1935: 1928: 1914: 1913: 1910: 1903: 1896: 1882: 1881: 1878: 1871: 1864: 1850: 1849: 1846: 1839: 1832: 1818: 1817: 1814: 1807: 1800: 1786: 1785: 1782: 1775: 1768: 1754: 1753: 1750: 1743: 1736: 1722: 1721: 1718: 1711: 1704: 1690: 1689: 1686: 1679: 1672: 1658: 1657: 1654: 1647: 1640: 1626: 1625: 1622: 1615: 1608: 1594: 1593: 1590: 1583: 1576: 1562: 1561: 1558: 1551: 1544: 1530: 1529: 1526: 1519: 1512: 1498: 1497: 1494: 1487: 1480: 1466: 1465: 1462: 1455: 1448: 1434: 1433: 1430: 1423: 1416: 1402: 1401: 1400:1940s–present 1398: 1391: 1384: 1370: 1369: 1364: 1357: 1350: 1336: 1335: 1332: 1325: 1318: 1304: 1303: 1300: 1293: 1286: 1272: 1271: 1268: 1261: 1254: 1240: 1239: 1236: 1229: 1222: 1208: 1207: 1204: 1197: 1190: 1176: 1175: 1172: 1165: 1158: 1144: 1143: 1140: 1133: 1126: 1112: 1111: 1108: 1101: 1094: 1080: 1079: 1076: 1069: 1062: 1060:Czech Republic 1048: 1047: 1044: 1037: 1030: 1016: 1015: 1012: 1005: 998: 984: 983: 980: 973: 966: 952: 951: 946: 939: 932: 918: 917: 914: 907: 900: 886: 885: 882: 879: 878:Mandatory now 876: 866: 863: 862: 861: 854: 851: 848: 838: 835: 829: 826: 768:deltoid muscle 759: 756: 737:subcutaneously 701: 698: 697: 696: 681: 669: 658:bladder cancer 647:bladder cancer 627:Coley's toxins 623:Cancer vaccine 612: 609: 608: 607: 601: 593: 590: 589: 588: 577: 562: 555: 542: 539: 490:false positive 475: 472: 470: 467: 431:bladder cancer 414:Camille GuĂ©rin 384: 383: 381: 380: 373: 365: 363: 357: 356: 354: 353: 346: 338: 336: 330: 329: 327: 326: 322: 320: 314: 313: 311: 310: 302: 300: 294: 293: 289: 288: 286: 285: 282: 270: 257: 245: 231: 229: 223: 222: 218: 217: 215: 214: 191: 189: 183: 182: 169: 167:administration 161: 160: 158: 157: 139: 137: 131: 130: 123: 117: 116: 109: 99: 98: 95: 89: 88: 84: 83: 78: 72: 71: 64: 60: 59: 53: 52: 45: 26: 9: 6: 4: 3: 2: 8872: 8861: 8858: 8856: 8853: 8851: 8848: 8846: 8843: 8841: 8840:Live vaccines 8838: 8836: 8833: 8831: 8828: 8827: 8825: 8815: 8805: 8804: 8801: 8784: 8782: 8779: 8778: 8776: 8773: 8770: 8767: 8765: 8762: 8761: 8757: 8751: 8748: 8746: 8743: 8741: 8738: 8736: 8733: 8732: 8730: 8726: 8720: 8717: 8715: 8714: 8710: 8708: 8705: 8703: 8700: 8698: 8695: 8693: 8690: 8687: 8685: 8680: 8677: 8675: 8672: 8671: 8669: 8665: 8659: 8658:Drew Weissman 8656: 8654: 8651: 8649: 8646: 8644: 8643:H. Fred Clark 8641: 8639: 8636: 8634: 8631: 8629: 8626: 8624: 8621: 8619: 8616: 8614: 8613:Louis Pasteur 8611: 8609: 8608:Edward Jenner 8606: 8605: 8603: 8597: 8585: 8582: 8580: 8579:DTwP-HepB-Hib 8577: 8575: 8574:DTaP-IPV-HepB 8572: 8570: 8567: 8566: 8565:combination: 8564: 8562: 8559: 8557: 8554: 8552: 8549: 8547: 8544: 8540: 8537: 8533: 8530: 8528: 8525: 8524: 8523: 8520: 8518: 8515: 8513: 8510: 8508: 8505: 8504: 8503: 8500: 8498: 8495: 8494: 8492: 8488: 8480: 8477: 8475: 8472: 8471: 8469: 8468: 8466: 8464: 8463:Helminthiasis 8460: 8452: 8449: 8448: 8446: 8442: 8439: 8438: 8437: 8434: 8433: 8431: 8427: 8419: 8416: 8414: 8411: 8409: 8406: 8404: 8401: 8399: 8396: 8394: 8391: 8389: 8386: 8385: 8383: 8379: 8376: 8374: 8371: 8369: 8366: 8365: 8364:combination: 8363: 8361: 8358: 8354: 8351: 8349: 8346: 8345: 8343: 8341: 8338: 8336: 8333: 8331: 8328: 8324: 8321: 8319: 8316: 8314: 8311: 8309: 8306: 8304: 8301: 8299: 8296: 8294: 8291: 8289: 8286: 8284: 8281: 8279: 8276: 8274: 8271: 8269: 8266: 8264: 8261: 8259: 8256: 8254: 8251: 8250: 8249: 8246: 8244: 8241: 8239: 8236: 8234: 8231: 8227: 8224: 8222: 8219: 8218: 8217: 8214: 8212: 8209: 8207: 8204: 8202: 8199: 8197: 8194: 8190: 8187: 8185: 8182: 8181: 8180: 8177: 8175: 8172: 8170: 8167: 8165: 8162: 8160: 8157: 8153: 8150: 8148: 8145: 8143: 8140: 8137: 8133: 8130: 8129: 8128: 8125: 8121: 8118: 8117: 8116: 8113: 8111: 8108: 8106: 8103: 8102: 8100: 8096: 8088: 8085: 8083: 8080: 8078: 8075: 8074: 8072: 8068: 8065: 8063: 8062:DPT/DTwP/DTaP 8060: 8059: 8058:combination: 8057: 8055: 8052: 8048: 8045: 8043: 8040: 8039: 8038: 8035: 8031: 8028: 8027: 8026: 8023: 8021: 8018: 8016: 8013: 8009: 8006: 8004: 8001: 8000: 7999: 7996: 7994: 7991: 7989: 7986: 7982: 7979: 7977: 7974: 7973: 7972: 7971:Meningococcus 7969: 7967: 7964: 7962: 7961:Leptospirosis 7959: 7957: 7954: 7952: 7949: 7947: 7944: 7942: 7939: 7937: 7934: 7933: 7931: 7927: 7924: 7920: 7912: 7909: 7907: 7904: 7902: 7899: 7897: 7896:Vaccine court 7894: 7892: 7889: 7888: 7886: 7882: 7879: 7877: 7874: 7872: 7869: 7867: 7864: 7862: 7859: 7857: 7854: 7852: 7851:GAVI Alliance 7849: 7848: 7846: 7845: 7843: 7839: 7833: 7830: 7828: 7825: 7823: 7819: 7816: 7814: 7810: 7806: 7802: 7799: 7795: 7792: 7790: 7787: 7786: 7784: 7782: 7779: 7777: 7774: 7773: 7771: 7767: 7761: 7758: 7756: 7753: 7751: 7748: 7746: 7743: 7739: 7736: 7735: 7734: 7731: 7729: 7726: 7725: 7723: 7719: 7714: 7710: 7706: 7702: 7698: 7694: 7690: 7683: 7678: 7676: 7671: 7669: 7664: 7663: 7660: 7653: 7649: 7646: 7645: 7632: 7628: 7623: 7618: 7614: 7610: 7606: 7602: 7598: 7591: 7583: 7579: 7574: 7569: 7564: 7559: 7556:(9): 100728. 7555: 7551: 7547: 7540: 7532: 7528: 7524: 7518: 7499: 7495: 7488: 7482: 7474: 7470: 7465: 7460: 7455: 7450: 7446: 7442: 7438: 7434: 7430: 7423: 7415: 7411: 7406: 7401: 7397: 7393: 7390:(9): 100728. 7389: 7385: 7381: 7374: 7366: 7362: 7357: 7352: 7348: 7344: 7340: 7336: 7332: 7325: 7317: 7313: 7309: 7305: 7301: 7297: 7293: 7289: 7282: 7274: 7270: 7265: 7260: 7256: 7252: 7248: 7244: 7240: 7233: 7217: 7213: 7207: 7199: 7195: 7191: 7187: 7182: 7177: 7173: 7169: 7165: 7161: 7157: 7151: 7143: 7139: 7135: 7131: 7126: 7121: 7117: 7113: 7109: 7105: 7101: 7094: 7086: 7082: 7077: 7072: 7067: 7062: 7058: 7054: 7050: 7046: 7042: 7035: 7027: 7023: 7019: 7015: 7010: 7005: 7001: 6997: 6993: 6986: 6978: 6974: 6969: 6964: 6960: 6956: 6952: 6945: 6929: 6926:(in French). 6925: 6921: 6915: 6896: 6892: 6886: 6879: 6878: 6871: 6863: 6859: 6855: 6851: 6847: 6843: 6836: 6820: 6816: 6812: 6805: 6797: 6790: 6782: 6778: 6773: 6768: 6763: 6758: 6754: 6750: 6746: 6739: 6722: 6718: 6714: 6710: 6706: 6702: 6695: 6686: 6682: 6678: 6674: 6669: 6664: 6659: 6654: 6651:(1): 816345. 6650: 6646: 6642: 6635: 6617: 6613: 6609: 6605: 6600: 6599: 6595: 6591: 6584: 6577: 6574:From p. 230: 6563: 6559: 6556:(in German). 6555: 6551: 6544: 6536: 6532: 6531: 6523: 6516: 6512: 6508: 6504: 6498: 6491: 6477: 6473: 6469: 6468: 6460: 6444: 6440: 6437:(in French). 6436: 6432: 6425: 6417: 6413: 6408: 6403: 6399: 6395: 6391: 6387: 6383: 6376: 6368: 6364: 6359: 6354: 6350: 6346: 6342: 6338: 6334: 6327: 6312: 6308: 6304: 6297: 6281: 6277: 6273: 6266: 6247: 6243: 6236: 6230: 6215: 6211: 6207: 6201: 6199: 6180: 6176: 6169: 6163: 6147: 6143: 6139: 6133: 6117: 6113: 6107: 6091: 6087: 6081: 6065: 6061: 6055: 6047: 6041: 6037: 6033: 6026: 6010: 6006: 6000: 5984: 5980: 5976: 5970: 5954: 5950: 5944: 5933: 5929: 5922: 5916: 5908: 5904: 5899: 5894: 5889: 5884: 5880: 5876: 5872: 5865: 5857: 5853: 5848: 5843: 5839: 5835: 5831: 5827: 5823: 5816: 5808: 5804: 5800: 5794: 5786: 5782: 5777: 5772: 5767: 5762: 5758: 5754: 5751:(9): e04898. 5750: 5746: 5742: 5735: 5719: 5715: 5711: 5704: 5696: 5692: 5688: 5684: 5677: 5669: 5665: 5661: 5655: 5639: 5635: 5631: 5625: 5609: 5605: 5599: 5591: 5587: 5583: 5579: 5572: 5556: 5552: 5548: 5541: 5525: 5521: 5520: 5515: 5509: 5493: 5489: 5485: 5479: 5471: 5467: 5463: 5459: 5455: 5451: 5444: 5428: 5424: 5420: 5414: 5406: 5402: 5397: 5392: 5387: 5382: 5378: 5374: 5373:PLOS 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2035: 2034: 2024: 2021: 2017: 2014: 2010: 2007: 2004: 1999: 1996: 1992: 1989: 1988: 1975: 1959: 1948: 1947: 1943: 1927: 1916: 1915: 1912:1952–present 1911: 1895: 1884: 1883: 1879: 1863: 1852: 1851: 1847: 1831: 1820: 1819: 1815: 1799: 1788: 1787: 1783: 1767: 1756: 1755: 1751: 1735: 1724: 1723: 1720:1928–present 1719: 1703: 1692: 1691: 1688:1962–present 1687: 1671: 1660: 1659: 1656:1928–present 1655: 1639: 1628: 1627: 1623: 1607: 1596: 1595: 1592:1955–present 1591: 1575: 1564: 1563: 1559: 1543: 1532: 1531: 1528:1950–present 1527: 1511: 1500: 1499: 1495: 1479: 1468: 1467: 1463: 1447: 1436: 1435: 1431: 1415: 1404: 1403: 1399: 1383: 1372: 1371: 1365: 1349: 1338: 1337: 1333: 1317: 1306: 1305: 1302:1953–present 1301: 1285: 1274: 1273: 1269: 1253: 1242: 1241: 1237: 1221: 1210: 1209: 1205: 1189: 1178: 1177: 1173: 1157: 1146: 1145: 1141: 1125: 1114: 1113: 1109: 1093: 1082: 1081: 1077: 1061: 1050: 1049: 1046:1948–present 1045: 1029: 1018: 1017: 1014:1951–present 1013: 997: 986: 985: 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Retrieved 2384: 2367:double-blind 2363: 2359: 2347: 2332: 2321: 2310: 2302: 2298:Mantoux test 2290: 2267: 2256: 2234: 2229: 2225: 2221: 2207: 2203: 2191: 2180: 2162:freeze dried 2159: 2136: 2123: 2094: 2083: 2077: 831: 815: 811: 796: 773: 761: 753: 746: 726: 711: 693:colon cancer 664:A number of 655: 643:inflammation 614: 604:Buruli ulcer 595: 592:Mycobacteria 544: 524: 517: 513: 505: 501: 497: 493:Mantoux test 486:tuberculosis 483: 474:Tuberculosis 469:Medical uses 460: 449: 439: 435: 423:Buruli ulcer 406:tuberculosis 397: 393: 389: 387: 227:Legal status 221:Legal status 176:intravesical 172:Percutaneous 135:License data 76:Vaccine type 66: 29: 8771:from market 8667:Controversy 8601:researchers 8517:Hepatitis B 8403:Hepatitis C 8348:Chicken pox 8174:Hepatitis E 8169:Hepatitis B 8164:Hepatitis A 8110:Chikungunya 8087:Shigellosis 7941:Brucellosis 7827:Therapeutic 7781:Inactivated 7721:Development 7709:Inoculation 7701:Vaccination 7648:BCG Vaccine 6441:: 211–216. 6255:11 February 5989:14 February 5119:26 December 4795:5 September 4762:5 September 4610:5 September 4255:: 6230409. 3387:10665/66120 2597:18 November 2562:5 September 2214:vaccination 2196:Robert Koch 2074:Manufacture 2031:Middle East 1880:1960s–1987 1862:Switzerland 1478:Netherlands 1334:1950s–2015 776:lymph nodes 741:antibiotics 729:intradermal 292:Identifiers 284:JP: Rx-only 180:intradermal 154:BCG Vaccine 121:MedlinePlus 93:Trade names 34:BCG vaccine 8824:Categories 8702:Thiomersal 8648:Paul Offit 8623:Jonas Salk 8599:Inventors/ 8470:research: 8447:research: 8384:research: 8313:Skycovione 8303:Sanofi–GSK 8248:SARS-CoV-2 8159:Hantavirus 8120:rVSV-ZEBOV 8105:Adenovirus 8073:research: 7951:Diphtheria 7789:Attenuated 7607:: 101414. 7222:16 January 6705:The Lancet 6505:virulentes 6317:29 January 6220:29 January 6188:29 January 6122:2 February 6096:2 February 5634:mhlw.go.jp 5185:20 October 5024:2 February 4630:toronto.ca 4541:21 October 2376:References 2185:. 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