3220:
3240:
993:
Cheung CY, Op den
Buijsch RA, Wong KM, Chan HW, Chau KF, Li CS, Leung KT, Kwan TH, de Vrie JE, Wijnen PA, van Dieijen-Visser MP, Bekers O (June 2006). "Influence of different allelic variants of the CYP3A and ABCB1 genes on the tacrolimus pharmacokinetic profile of Chinese renal transplant
477:
as well as several extra exons which may or may not be included in transcripts produced from this region. Previously another CYP3A member, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4.
1134:
Watanabe A, Nakamura K, Okudaira N, Okazaki O, Sudo K (July 2007). "Risk assessment for drug-drug interaction caused by metabolism-based inhibition of CYP3A using automated in vitro assay systems and its application in the early drug discovery process".
1172:
Kharasch ED, Walker A, Isoherranen N, Hoffer C, Sheffels P, Thummel K, Whittington D, Ensign D (October 2007). "Influence of CYP3A5 genotype on the pharmacokinetics and pharmacodynamics of the cytochrome P4503A probes alfentanil and midazolam".
737:
Reid JM, Kuffel MJ, Ruben SL, Morales JJ, Rinehart KL, Squillace DP, Ames MM (September 2002). "Rat and human liver cytochrome P-450 isoform metabolism of ecteinascidin 743 does not predict gender-dependent toxicity in humans".
2838:
2534:
2707:
2743:
882:
Somogyi AA, Menelaou A, Fullston SV (October 2004). "CYP3A4 mediates dextropropoxyphene N-demethylation to nordextropropoxyphene: human in vitro and in vivo studies and lack of CYP2D6 involvement".
2812:
2775:
1097:
He P, Court MH, Greenblatt DJ, von Moltke LL (November 2006). "Human pregnane X receptor: genetic polymorphisms, alternative mRNA splice variants, and cytochrome P450 3A metabolic activity".
2834:
956:
Bochud M, Eap CB, Elston RC, Bovet P, Maillard M, Schild L, Shamlaye C, Burnier M (May 2006). "Association of CYP3A5 genotypes with blood pressure and renal function in
African families".
700:
Miyazawa M, Shindo M, Shimada T (October 2001). "Roles of cytochrome P450 3A enzymes in the 2-hydroxylation of 1,4-cineole, a monoterpene cyclic ether, by rat and human liver microsomes".
2607:
530:
Gellner K, Eiselt R, Hustert E, Arnold H, Koch I, Haberl M, et al. (March 2001). "Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene".
1060:
Kirby B, Kharasch ED, Thummel KT, Narang VS, Hoffer CJ, Unadkat JD (November 2006). "Simultaneous measurement of in vivo P-glycoprotein and cytochrome P450 3A activities".
1870:
407:
which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The CYP3A cluster consists of four genes:
117:
2335:
1779:
845:
Sunman JA, Hawke RL, LeCluyse EL, Kashuba AD (March 2004). "Kupffer cell-mediated IL-2 suppression of CYP3A activity in human hepatocytes".
495:
1919:
919:
Thompson EE, Kuttab-Boulos H, Yang L, Roe BA, Di Rienzo A (2006). "Sequence diversity and haplotype structure at the human CYP3A cluster".
613:
Smith G, Stubbins MJ, Harries LW, Wolf CR (December 1998). "Molecular genetics of the human cytochrome P450 monooxygenase superfamily".
2091:
2073:
2069:
1409:
1232:
2697:
1758:
1278:
2590:
671:
Finta C, Zaphiropoulos PG (December 2000). "The human cytochrome P450 3A locus. Gene evolution by capture of downstream exons".
3281:
2765:
2504:
2342:
2051:
1575:
802:
Dowling TC, Briglia AE, Fink JC, Hanes DS, Light PD, Stackiewicz L, Karyekar CS, Eddington ND, Weir MR, Henrich WL (May 2003).
2862:
642:
Lamba JK, Lin YS, Schuetz EG, Thummel KE (November 2002). "Genetic contribution to variable human CYP3A-mediated metabolism".
2438:
1995:
1911:
2482:
2665:
2236:
1935:
2939:
2638:
1975:
1210:
2314:
2677:
2623:
2112:
1953:
1832:
1531:
761:"Expression of paclitaxel-inactivating CYP3A activity in human colorectal cancer: implications for drug therapy"
2298:
2105:
3095:
2009:
1979:
1939:
1927:
1225:
2163:
2077:
2065:
2906:
2755:
2215:
1915:
1583:
3274:
3210:
2497:
2098:
2037:
2033:
2021:
2017:
2013:
3196:
3183:
3170:
3157:
3144:
3131:
3118:
3080:
2901:
2852:
2824:
2792:
2401:
2286:
2055:
44:
3305:
3090:
3044:
2987:
2525:
2470:
2208:
2155:
2150:
2005:
1856:
1253:
1218:
469:
2992:
2747:
2538:
2257:
2130:
804:"Characterization of hepatic cytochrome p4503A activity in patients with end-stage renal disease"
461:
453:
445:
247:
3315:
2886:
2802:
2551:
2084:
2029:
2025:
1991:
1923:
1505:
3267:
3013:
2932:
2682:
2655:
2490:
2321:
1827:
1023:
Rais N, Chawla YK, Kohli KK (June 2006). "CYP3A phenotypes and genotypes in North
Indians".
3300:
3085:
2797:
2760:
2521:
2512:
2279:
2176:
2047:
1946:
1587:
61:
8:
3310:
3049:
2783:
2431:
2137:
1965:
759:
MartĂnez C, GarcĂa-MartĂn E, Pizarro RM, GarcĂa-Gamito FJ, AgĂşndez JA (September 2002).
2982:
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1931:
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37:
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965:
928:
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539:
396:
3075:
3059:
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2670:
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1249:
400:
578:
500:
National Center for
Biotechnology Information, U.S. National Library of Medicine
3255:
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2229:
2189:
2170:
2144:
1110:
1073:
1007:
404:
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626:
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2715:
2711:
1986:
1960:
1864:
1850:
1843:
1749:
1729:
1722:
1705:
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1630:
1623:
1616:
1609:
1602:
1570:
1563:
1194:
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1148:
1118:
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1044:
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932:
903:
866:
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634:
3191:
3126:
2962:
1556:
1512:
858:
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367:
2847:
1241:
437:
3165:
3139:
2816:
2779:
2723:
2517:
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1245:
81:
69:
57:
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3219:
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2413:
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356:
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1715:
1667:
1640:
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1435:
1430:
1414:
1334:
1329:
1309:
429:
187:
146:
884:
Xenobiotica; the Fate of
Foreign Compounds in Biological Systems
702:
Xenobiotica; the Fate of
Foreign Compounds in Biological Systems
615:
Xenobiotica; the Fate of
Foreign Compounds in Biological Systems
565:
Zaphiropoulos PG (June 2003). "A map of the mouse Cyp3a locus".
3178:
2948:
2733:
2728:
2687:
1549:
1545:
1535:
1521:
1517:
1485:
1480:
1475:
1455:
1450:
1445:
1440:
1404:
1399:
1394:
1374:
1369:
1364:
1359:
1354:
1349:
1344:
1339:
1324:
1319:
1314:
1304:
1299:
1283:
1273:
1268:
1171:
1133:
423:
417:
411:
337:
103:
3152:
2880:
2615:
2573:
2566:
2561:
2556:
1836:
1698:
3239:
992:
918:
2660:
2648:
2643:
2633:
2628:
2611:
2585:
1890:
1096:
517:"Entrez Gene: CYP3A cytochrome P450, family 3, subfamily A"
389:
2917:
1059:
844:
529:
399:
includes all the known members of the 3A subfamily of the
612:
881:
801:
736:
641:
3208:
699:
955:
670:
3292:
1022:
48:, cytochrome P450, family 3, subfamily A, CYP3
3275:
2933:
2498:
1226:
564:
392:locus. A homologous locus is found in mice.
558:
523:
3282:
3268:
2940:
2926:
2505:
2491:
1233:
1219:
1025:European Journal of Clinical Pharmacology
819:
784:
403:superfamily of genes. These genes encode
511:
509:
3293:
1175:Clinical Pharmacology and Therapeutics
808:Clinical Pharmacology and Therapeutics
382:Cytochrome P450, family 3, subfamily A
2921:
2486:
1214:
506:
3234:
2698:24-hydroxycholesterol 7α-hydroxylase
13:
970:10.1097/01.hjh.0000222763.84605.4a
605:
14:
3327:
3238:
3218:
1099:Journal of Clinical Pharmacology
1062:Journal of Clinical Pharmacology
544:10.1097/00008571-200103000-00002
2678:Cholesterol 7 alpha-hydroxylase
2624:Flavin-containing monooxygenase
1137:Drug Metabolism and Disposition
847:Drug Metabolism and Disposition
644:Advanced Drug Delivery Reviews
488:
436:The region also contains four
1:
821:10.1016/S0009-9236(03)00056-0
685:10.1016/S0378-1119(00)00470-4
656:10.1016/S0169-409X(02)00066-2
481:
3254:. You can help Knowledge by
921:The Pharmacogenomics Journal
7:
2947:
2907:Deoxyhypusine monooxygenase
579:10.1080/1042517031000089478
10:
3332:
3233:
3104:
3096:Michaelis–Menten kinetics
3068:
3037:
3006:
2955:
2902:Ecdysone 20-monooxygenase
2861:
2853:Stearoyl-CoA desaturase-1
2833:
2825:Dopamine beta-hydroxylase
2811:
2793:Phenylalanine hydroxylase
2774:
2742:
2706:
2606:
2533:
2448:
2423:
2352:
2122:
1900:
1819:
1677:
1494:
1423:
1383:
1292:
1261:
1037:10.1007/s00228-006-0105-3
896:10.1080/00498250400008371
765:British Journal of Cancer
714:10.1080/00498250110065595
496:"Human PubMed Reference:"
371:
366:
362:
355:
336:
321:
308:
304:
289:
285:
278:
265:
261:
244:
240:
233:
222:
218:
199:
195:
186:
175:
171:
158:
154:
145:
134:
130:
115:
111:
102:
87:
80:
76:
55:
52:
42:
35:
30:
26:
21:
2988:Diffusion-limited enzyme
1111:10.1177/0091270006292125
1074:10.1177/0091270006292625
1008:10.2217/14622416.7.4.563
740:Clinical Cancer Research
1187:10.1038/sj.clpt.6100237
958:Journal of Hypertension
627:10.1080/004982598238868
3250:-related article is a
2887:Squalene monooxygenase
2803:Tryptophan hydroxylase
2552:HIF prolyl-hydroxylase
1149:10.1124/dmd.107.015016
933:10.1038/sj.tpj.6500347
777:10.1038/sj.bjc.6600494
3081:Eadie–Hofstee diagram
3014:Allosteric regulation
2683:Methane monooxygenase
2656:Nitric oxide synthase
3091:Lineweaver–Burk plot
2798:Tyrosine hydroxylase
2522:steroid hydroxylases
859:10.1124/dmd.32.3.359
2748:iron–sulfur protein
3050:Enzyme superfamily
2983:Enzyme promiscuity
2547:Prolyl hydroxylase
3263:
3262:
3206:
3205:
2915:
2914:
2581:Lysyl hydroxylase
2480:
2479:
379:
378:
375:
374:
351:
350:
317:
316:
298:
297:
274:
273:
255:
254:
229:
228:
212:
211:
182:
181:
165:
164:
141:
140:
124:
123:
70:CYP3A - orthologs
3323:
3284:
3277:
3270:
3242:
3235:
3223:
3222:
3214:
3086:Hanes–Woolf plot
3029:Enzyme activator
3024:Enzyme inhibitor
2998:Enzyme catalysis
2942:
2935:
2928:
2919:
2918:
2507:
2500:
2493:
2484:
2483:
1252:(Most belong to
1235:
1228:
1221:
1212:
1211:
1206:
1168:
1130:
1093:
1056:
1019:
996:Pharmacogenomics
989:
952:
915:
878:
841:
823:
798:
788:
755:
733:
696:
667:
638:
599:
598:
562:
556:
555:
532:Pharmacogenetics
527:
521:
520:
513:
504:
503:
492:
384:, also known as
364:
363:
347:
332:
327:
312:
302:
301:
293:
283:
282:
279:RefSeq (protein)
269:
259:
258:
250:
238:
237:
216:
215:
193:
192:
169:
168:
152:
151:
128:
127:
109:
108:
78:
77:
72:
47:
40:
19:
18:
3331:
3330:
3326:
3325:
3324:
3322:
3321:
3320:
3306:Cytochrome P450
3291:
3290:
3289:
3288:
3231:
3229:
3217:
3209:
3207:
3202:
3114:Oxidoreductases
3100:
3076:Enzyme kinetics
3064:
3060:List of enzymes
3033:
3002:
2973:Catalytic triad
2951:
2946:
2916:
2911:
2865:- miscellaneous
2857:
2829:
2807:
2770:
2738:
2702:
2693:14α-demethylase
2602:
2529:
2514:Oxidoreductases
2511:
2481:
2476:
2444:
2419:
2381:Halloween genes
2348:
2118:
1896:
1815:
1673:
1490:
1419:
1379:
1288:
1257:
1250:cytochrome P450
1239:
1209:
1105:(11): 1356–69.
650:(10): 1271–94.
621:(12): 1129–65.
608:
606:Further reading
603:
602:
563:
559:
528:
524:
515:
514:
507:
494:
493:
489:
484:
401:cytochrome P450
368:View/Edit Human
345:
330:
325:
322:Location (UCSC)
310:
291:
267:
246:
204:
56:
43:
36:
17:
12:
11:
5:
3329:
3319:
3318:
3313:
3308:
3303:
3287:
3286:
3279:
3272:
3264:
3261:
3260:
3243:
3228:
3227:
3204:
3203:
3201:
3200:
3187:
3174:
3161:
3148:
3135:
3122:
3108:
3106:
3102:
3101:
3099:
3098:
3093:
3088:
3083:
3078:
3072:
3070:
3066:
3065:
3063:
3062:
3057:
3052:
3047:
3041:
3039:
3038:Classification
3035:
3034:
3032:
3031:
3026:
3021:
3016:
3010:
3008:
3004:
3003:
3001:
3000:
2995:
2990:
2985:
2980:
2975:
2970:
2965:
2959:
2957:
2953:
2952:
2945:
2944:
2937:
2930:
2922:
2913:
2912:
2910:
2909:
2904:
2899:
2894:
2889:
2884:
2877:Heme oxygenase
2874:
2872:Cyclooxygenase
2868:
2866:
2859:
2858:
2856:
2855:
2850:
2844:
2842:
2831:
2830:
2828:
2827:
2821:
2819:
2809:
2808:
2806:
2805:
2800:
2795:
2789:
2787:
2772:
2771:
2769:
2768:
2763:
2758:
2752:
2750:
2740:
2739:
2737:
2736:
2731:
2726:
2720:
2718:
2704:
2703:
2701:
2700:
2695:
2690:
2685:
2680:
2675:
2674:
2673:
2668:
2663:
2653:
2652:
2651:
2646:
2641:
2636:
2631:
2620:
2618:
2604:
2603:
2601:
2600:
2599:
2598:
2593:
2583:
2578:
2577:
2576:
2571:
2570:
2569:
2564:
2559:
2543:
2541:
2539:2-oxoglutarate
2531:
2530:
2510:
2509:
2502:
2495:
2487:
2478:
2477:
2475:
2474:
2467:
2460:
2452:
2450:
2446:
2445:
2443:
2442:
2435:
2427:
2425:
2421:
2420:
2418:
2417:
2410:
2378:
2377:
2376:
2364:
2356:
2354:
2350:
2349:
2347:
2346:
2339:
2332:
2325:
2318:
2311:
2310:
2309:
2302:
2290:
2283:
2276:
2269:
2268:
2267:
2264:
2254:
2247:
2240:
2233:
2226:
2219:
2212:
2205:
2204:
2203:
2198:
2186:
2185:
2184:
2179:
2167:
2160:
2159:
2158:
2153:
2141:
2134:
2126:
2124:
2120:
2119:
2117:
2116:
2109:
2102:
2095:
2088:
2081:
2059:
2041:
1999:
1983:
1969:
1957:
1950:
1943:
1904:
1902:
1898:
1897:
1895:
1894:
1887:
1886:
1885:
1875:
1874:
1873:
1861:
1860:
1859:
1847:
1840:
1823:
1821:
1817:
1816:
1814:
1813:
1803:
1793:
1783:
1776:
1766:
1746:
1726:
1719:
1709:
1702:
1692:
1681:
1679:
1675:
1674:
1672:
1671:
1661:
1651:
1644:
1634:
1627:
1620:
1613:
1606:
1599:
1567:
1560:
1553:
1539:
1525:
1509:
1498:
1496:
1492:
1491:
1489:
1488:
1483:
1478:
1473:
1468:
1463:
1458:
1453:
1448:
1443:
1438:
1433:
1427:
1425:
1421:
1420:
1418:
1417:
1412:
1407:
1402:
1397:
1391:
1389:
1381:
1380:
1378:
1377:
1372:
1367:
1362:
1357:
1352:
1347:
1342:
1337:
1332:
1327:
1322:
1317:
1312:
1307:
1302:
1296:
1294:
1290:
1289:
1287:
1286:
1281:
1276:
1271:
1265:
1263:
1259:
1258:
1238:
1237:
1230:
1223:
1215:
1208:
1207:
1169:
1131:
1094:
1068:(11): 1313–9.
1057:
1020:
990:
953:
916:
890:(10): 875–87.
879:
842:
799:
756:
746:(9): 2952–62.
734:
708:(10): 713–23.
697:
679:(1–2): 13–23.
668:
639:
609:
607:
604:
601:
600:
557:
522:
505:
486:
485:
483:
480:
475:
474:
466:
458:
450:
434:
433:
427:
421:
415:
405:monooxygenases
377:
376:
373:
372:
370:
360:
359:
353:
352:
349:
348:
343:
341:
334:
333:
328:
323:
319:
318:
315:
314:
306:
305:
299:
296:
295:
287:
286:
280:
276:
275:
272:
271:
263:
262:
256:
253:
252:
242:
241:
235:
231:
230:
227:
226:
220:
219:
213:
210:
209:
197:
196:
190:
184:
183:
180:
179:
173:
172:
166:
163:
162:
156:
155:
149:
143:
142:
139:
138:
132:
131:
125:
122:
121:
113:
112:
106:
100:
99:
94:
89:
85:
84:
74:
73:
54:
50:
49:
41:
33:
32:
28:
27:
24:
23:
15:
9:
6:
4:
3:
2:
3328:
3317:
3316:Protein stubs
3314:
3312:
3309:
3307:
3304:
3302:
3299:
3298:
3296:
3285:
3280:
3278:
3273:
3271:
3266:
3265:
3259:
3257:
3253:
3249:
3244:
3241:
3237:
3236:
3232:
3226:
3221:
3216:
3215:
3212:
3198:
3194:
3193:
3188:
3185:
3181:
3180:
3175:
3172:
3168:
3167:
3162:
3159:
3155:
3154:
3149:
3146:
3142:
3141:
3136:
3133:
3129:
3128:
3123:
3120:
3116:
3115:
3110:
3109:
3107:
3103:
3097:
3094:
3092:
3089:
3087:
3084:
3082:
3079:
3077:
3074:
3073:
3071:
3067:
3061:
3058:
3056:
3055:Enzyme family
3053:
3051:
3048:
3046:
3043:
3042:
3040:
3036:
3030:
3027:
3025:
3022:
3020:
3019:Cooperativity
3017:
3015:
3012:
3011:
3009:
3005:
2999:
2996:
2994:
2991:
2989:
2986:
2984:
2981:
2979:
2978:Oxyanion hole
2976:
2974:
2971:
2969:
2966:
2964:
2961:
2960:
2958:
2954:
2950:
2943:
2938:
2936:
2931:
2929:
2924:
2923:
2920:
2908:
2905:
2903:
2900:
2898:
2895:
2893:
2890:
2888:
2885:
2882:
2878:
2875:
2873:
2870:
2869:
2867:
2864:
2860:
2854:
2851:
2849:
2846:
2845:
2843:
2840:
2836:
2832:
2826:
2823:
2822:
2820:
2818:
2814:
2810:
2804:
2801:
2799:
2796:
2794:
2791:
2790:
2788:
2785:
2784:BH4 dependent
2781:
2777:
2773:
2767:
2764:
2762:
2759:
2757:
2754:
2753:
2751:
2749:
2745:
2741:
2735:
2732:
2730:
2727:
2725:
2722:
2721:
2719:
2717:
2713:
2709:
2705:
2699:
2696:
2694:
2691:
2689:
2686:
2684:
2681:
2679:
2676:
2672:
2669:
2667:
2664:
2662:
2659:
2658:
2657:
2654:
2650:
2647:
2645:
2642:
2640:
2637:
2635:
2632:
2630:
2627:
2626:
2625:
2622:
2621:
2619:
2617:
2613:
2609:
2605:
2597:
2594:
2592:
2589:
2588:
2587:
2584:
2582:
2579:
2575:
2572:
2568:
2565:
2563:
2560:
2558:
2555:
2554:
2553:
2550:
2549:
2548:
2545:
2544:
2542:
2540:
2536:
2532:
2527:
2523:
2519:
2515:
2508:
2503:
2501:
2496:
2494:
2489:
2488:
2485:
2473:
2472:
2468:
2466:
2465:
2461:
2459:
2458:
2454:
2453:
2451:
2447:
2441:
2440:
2436:
2434:
2433:
2429:
2428:
2426:
2422:
2416:
2415:
2411:
2408:
2404:
2403:
2398:
2394:
2390:
2386:
2382:
2379:
2375:
2372:
2371:
2370:
2369:
2365:
2363:
2362:
2358:
2357:
2355:
2351:
2345:
2344:
2340:
2338:
2337:
2333:
2331:
2330:
2326:
2324:
2323:
2319:
2317:
2316:
2312:
2308:
2307:
2303:
2301:
2300:
2296:
2295:
2294:
2291:
2289:
2288:
2284:
2282:
2281:
2277:
2275:
2274:
2270:
2265:
2262:
2261:
2260:
2259:
2255:
2253:
2252:
2248:
2246:
2245:
2241:
2239:
2238:
2234:
2232:
2231:
2227:
2225:
2224:
2220:
2218:
2217:
2213:
2211:
2210:
2206:
2202:
2199:
2197:
2194:
2193:
2192:
2191:
2187:
2183:
2180:
2178:
2175:
2174:
2173:
2172:
2168:
2166:
2165:
2161:
2157:
2154:
2152:
2149:
2148:
2147:
2146:
2142:
2140:
2139:
2135:
2133:
2132:
2128:
2127:
2125:
2121:
2115:
2114:
2110:
2108:
2107:
2103:
2101:
2100:
2096:
2094:
2093:
2089:
2087:
2086:
2082:
2079:
2075:
2071:
2067:
2063:
2060:
2057:
2053:
2049:
2045:
2042:
2039:
2035:
2031:
2027:
2023:
2019:
2015:
2011:
2007:
2003:
2000:
1997:
1993:
1989:
1988:
1984:
1981:
1977:
1973:
1970:
1967:
1963:
1962:
1958:
1956:
1955:
1951:
1949:
1948:
1944:
1941:
1937:
1933:
1929:
1925:
1921:
1917:
1913:
1909:
1906:
1905:
1903:
1899:
1893:
1892:
1888:
1884:
1881:
1880:
1879:
1876:
1872:
1869:
1868:
1867:
1866:
1862:
1858:
1855:
1854:
1853:
1852:
1848:
1846:
1845:
1841:
1838:
1834:
1830:
1829:
1825:
1824:
1822:
1818:
1811:
1807:
1804:
1801:
1797:
1794:
1791:
1787:
1784:
1782:
1781:
1777:
1774:
1770:
1767:
1764:
1760:
1756:
1752:
1751:
1747:
1744:
1740:
1736:
1732:
1731:
1727:
1725:
1724:
1720:
1717:
1713:
1710:
1708:
1707:
1703:
1700:
1696:
1693:
1690:
1686:
1683:
1682:
1680:
1676:
1669:
1665:
1662:
1659:
1655:
1652:
1650:
1649:
1645:
1642:
1638:
1635:
1633:
1632:
1628:
1626:
1625:
1621:
1619:
1618:
1614:
1612:
1611:
1607:
1605:
1604:
1600:
1597:
1593:
1589:
1585:
1581:
1577:
1573:
1572:
1568:
1566:
1565:
1561:
1559:
1558:
1554:
1551:
1547:
1543:
1540:
1537:
1533:
1529:
1526:
1523:
1519:
1515:
1514:
1510:
1507:
1503:
1500:
1499:
1497:
1493:
1487:
1484:
1482:
1479:
1477:
1474:
1472:
1469:
1467:
1464:
1462:
1459:
1457:
1454:
1452:
1449:
1447:
1444:
1442:
1439:
1437:
1434:
1432:
1429:
1428:
1426:
1422:
1416:
1413:
1411:
1408:
1406:
1403:
1401:
1398:
1396:
1393:
1392:
1390:
1387:
1382:
1376:
1373:
1371:
1368:
1366:
1363:
1361:
1358:
1356:
1353:
1351:
1348:
1346:
1343:
1341:
1338:
1336:
1333:
1331:
1328:
1326:
1323:
1321:
1318:
1316:
1313:
1311:
1308:
1306:
1303:
1301:
1298:
1297:
1295:
1291:
1285:
1282:
1280:
1277:
1275:
1272:
1270:
1267:
1266:
1264:
1260:
1255:
1251:
1247:
1243:
1236:
1231:
1229:
1224:
1222:
1217:
1216:
1213:
1204:
1200:
1196:
1192:
1188:
1184:
1181:(4): 410–26.
1180:
1176:
1170:
1166:
1162:
1158:
1154:
1150:
1146:
1143:(7): 1232–8.
1142:
1138:
1132:
1128:
1124:
1120:
1116:
1112:
1108:
1104:
1100:
1095:
1091:
1087:
1083:
1079:
1075:
1071:
1067:
1063:
1058:
1054:
1050:
1046:
1042:
1038:
1034:
1031:(6): 417–22.
1030:
1026:
1021:
1017:
1013:
1009:
1005:
1002:(4): 563–74.
1001:
997:
994:recipients".
991:
987:
983:
979:
975:
971:
967:
963:
959:
954:
950:
946:
942:
938:
934:
930:
927:(2): 105–14.
926:
922:
917:
913:
909:
905:
901:
897:
893:
889:
885:
880:
876:
872:
868:
864:
860:
856:
853:(3): 359–63.
852:
848:
843:
839:
835:
831:
827:
822:
817:
814:(5): 427–34.
813:
809:
805:
800:
796:
792:
787:
782:
778:
774:
770:
766:
762:
757:
753:
749:
745:
741:
735:
731:
727:
723:
719:
715:
711:
707:
703:
698:
694:
690:
686:
682:
678:
674:
669:
665:
661:
657:
653:
649:
645:
640:
636:
632:
628:
624:
620:
616:
611:
610:
596:
592:
588:
584:
580:
576:
573:(3): 155–62.
572:
568:
561:
553:
549:
545:
541:
538:(2): 111–21.
537:
533:
526:
518:
512:
510:
501:
497:
491:
487:
479:
472:
471:
467:
464:
463:
459:
456:
455:
451:
448:
447:
443:
442:
441:
439:
431:
428:
425:
422:
419:
416:
413:
410:
409:
408:
406:
402:
398:
393:
391:
388:, is a human
387:
383:
369:
365:
361:
358:
354:
344:
342:
339:
335:
329:
324:
320:
313:
307:
303:
300:
294:
288:
284:
281:
277:
270:
264:
260:
257:
251:
249:
243:
239:
236:
234:RefSeq (mRNA)
232:
225:
221:
217:
214:
208:
207:
203:
198:
194:
191:
189:
185:
178:
174:
170:
167:
161:
157:
153:
150:
148:
144:
137:
133:
129:
126:
120:
119:
114:
110:
107:
105:
101:
98:
95:
93:
90:
86:
83:
79:
75:
71:
67:
63:
59:
51:
46:
39:
34:
29:
25:
20:
3256:expanding it
3245:
3230:
3192:Translocases
3189:
3176:
3163:
3150:
3137:
3127:Transferases
3124:
3111:
2968:Binding site
2716:flavoprotein
2520:, including
2518:dioxygenases
2469:
2462:
2455:
2437:
2430:
2412:
2406:
2400:
2396:
2392:
2388:
2384:
2366:
2359:
2341:
2334:
2327:
2320:
2313:
2304:
2297:
2292:
2285:
2278:
2271:
2256:
2249:
2242:
2235:
2228:
2221:
2214:
2207:
2188:
2169:
2162:
2143:
2136:
2129:
2111:
2104:
2097:
2090:
2083:
2061:
2043:
2001:
1985:
1971:
1959:
1952:
1945:
1907:
1889:
1877:
1863:
1849:
1842:
1826:
1805:
1795:
1785:
1778:
1768:
1748:
1728:
1721:
1711:
1704:
1694:
1684:
1663:
1653:
1646:
1636:
1629:
1622:
1615:
1608:
1601:
1569:
1562:
1555:
1541:
1527:
1511:
1501:
1385:
1178:
1174:
1140:
1136:
1102:
1098:
1065:
1061:
1028:
1024:
999:
995:
964:(5): 923–9.
961:
957:
924:
920:
887:
883:
850:
846:
811:
807:
771:(6): 681–6.
768:
764:
743:
739:
705:
701:
676:
672:
647:
643:
618:
614:
570:
567:DNA Sequence
566:
560:
535:
531:
525:
499:
490:
476:
468:
460:
452:
444:
435:
394:
385:
381:
380:
309:
290:
266:
245:
223:
200:
176:
159:
135:
116:
96:
91:
53:External IDs
3301:Human genes
2963:Active site
1242:Cytochromes
438:pseudogenes
31:Identifiers
3311:EC 1.14.14
3295:Categories
3166:Isomerases
3140:Hydrolases
3007:Regulation
2848:Tyrosinase
2815:: reduced
2778:: reduced
2746:: reduced
2710:: reduced
2449:CYP701-999
2424:CYP501-699
2353:CYP301-499
2123:CYP101-281
1246:oxygenases
482:References
395:The CYP3A
16:Human gene
3045:EC number
2817:ascorbate
2780:pteridine
2457:CYP704B22
470:CYP3A137P
248:NM_000775
82:Orthologs
58:GeneCards
3069:Kinetics
2993:Cofactor
2956:Activity
2471:CYP720A1
2439:CYP504B1
2414:CYP318A1
2407:CYP315A1
2402:CYP314A1
2397:CYP307A2
2393:CYP307A1
2389:CYP306A1
2385:CYP302A1
2361:CYP303A1
2336:CYP199A2
2315:CYP176A1
2273:CYP154C3
2237:CYP125A1
2223:CYP119A1
2216:CYP113A1
2164:CYP106A2
2138:CYP102A1
2131:CYP101A1
1901:CYP71-99
1820:CYP51-69
1678:CYP21-49
1203:25122764
1195:17554244
1165:11204475
1157:17392390
1127:35139870
1119:17050801
1090:10964615
1082:17050796
1053:24149704
1045:16758258
1016:16753004
986:30703443
978:16612255
949:10102745
941:16314882
904:15764408
875:30506452
867:14977871
838:23774236
830:12732843
795:12237780
752:12231541
730:41495172
722:11695850
693:11137287
664:12406645
595:21317627
587:14509827
552:11266076
462:CYP3A54P
454:CYP3A52P
446:CYP3A51P
357:Wikidata
3248:protein
3225:Biology
3179:Ligases
2949:Enzymes
2863:1.14.99
2841:: other
2835:1.14.18
2813:1.14.17
2776:1.14.16
2744:1.14.15
2708:1.14.14
2608:1.14.13
2535:1.14.11
2343:CYP255A
2322:CYP183A
2287:CYP161C
2280:CYP158A
2113:CYP99A3
2106:CYP97C1
2099:CYP93E1
2092:CYP90C1
2085:CYP88D6
1954:CYP73A1
1947:CYP72A1
1495:CYP5-20
912:7680532
786:2364247
635:9890157
430:CYP3A43
188:UniProt
147:Ensembl
88:Species
38:Aliases
3211:Portal
3153:Lyases
2712:flavin
2591:ALKBH1
2464:CYP710
2432:CYP503
2368:CYP305
2329:CYP197
2293:CYP170
2258:CYP152
2251:CYP147
2244:CYP139
2230:CYP123
2209:CYP111
2190:CYP109
2171:CYP107
2145:CYP105
1384:CYP3 (
1201:
1193:
1163:
1155:
1125:
1117:
1088:
1080:
1051:
1043:
1014:
984:
976:
947:
939:
910:
902:
873:
865:
836:
828:
793:
783:
750:
728:
720:
691:
662:
633:
593:
585:
550:
424:CYP3A7
418:CYP3A5
412:CYP3A4
340:search
338:PubMed
104:Entrez
3246:This
3105:Types
2881:HMOX1
2616:NADPH
2574:P4HTM
2567:EGLN3
2562:EGLN2
2557:EGLN1
2528:1.14)
2062:CYP81
2044:CYP80
2002:CYP79
1987:CYP76
1972:CYP75
1961:CYP74
1908:CYP71
1891:CYP61
1878:CYP56
1865:CYP55
1851:CYP53
1844:CYP52
1828:CYP51
1806:CYP46
1796:CYP39
1786:CYP35
1780:CYP29
1769:CYP28
1750:CYP27
1730:CYP26
1723:CYP25
1712:CYP24
1706:CYP23
1695:CYP22
1685:CYP21
1664:CYP20
1654:CYP19
1648:CYP18
1637:CYP17
1631:CYP16
1624:CYP15
1617:CYP14
1610:CYP13
1603:CYP12
1571:CYP11
1564:CYP10
1386:CYP3A
1256:1.14)
1199:S2CID
1161:S2CID
1123:S2CID
1086:S2CID
1049:S2CID
982:S2CID
945:S2CID
908:S2CID
871:S2CID
834:S2CID
726:S2CID
591:S2CID
465:, and
426:, and
397:locus
386:CYP3A
97:Mouse
92:Human
62:CYP3A
45:CYP3A
22:CYP3A
3252:stub
3197:list
3190:EC7
3184:list
3177:EC6
3171:list
3164:EC5
3158:list
3151:EC4
3145:list
3138:EC3
3132:list
3125:EC2
3119:list
3112:EC1
2897:21A2
2892:17A1
2766:11A1
2761:11B2
2756:11B1
2724:19A1
2671:NOS3
2666:NOS2
2661:NOS1
2649:FMO5
2644:FMO4
2639:FMO3
2634:FMO2
2629:FMO1
2612:NADH
2586:AlkB
1557:CYP9
1542:CYP8
1528:CYP7
1513:CYP6
1502:CYP5
1424:CYP4
1293:CYP2
1262:CYP1
1191:PMID
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1115:PMID
1078:PMID
1041:PMID
1012:PMID
974:PMID
937:PMID
900:PMID
863:PMID
826:PMID
791:PMID
748:PMID
718:PMID
689:PMID
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660:PMID
631:PMID
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548:PMID
390:gene
118:1574
2734:2E1
2729:2D6
2714:or
2688:3A4
2614:or
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1940:BA1
1936:AV1
1932:AJ4
1471:F22
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1436:A22
1431:A11
1415:A43
1410:A37
1335:C19
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1145:doi
1107:doi
1070:doi
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1004:doi
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892:doi
855:doi
816:doi
781:PMC
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540:doi
346:n/a
331:n/a
326:n/a
311:n/a
292:n/a
268:n/a
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2022:B3
2020:,
2018:B2
2016:,
2014:B1
2012:,
2010:A2
2008:,
2006:A1
1996:M7
1994:,
1992:B6
1980:B1
1978:,
1976:A1
1966:D1
1938:,
1934:,
1930:,
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1922:,
1920:C3
1918:,
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1914:,
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1871:A1
1857:A1
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1800:A1
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1400:A5
1395:A4
1375:W1
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1365:S1
1360:R1
1355:J2
1350:F1
1345:E1
1340:D6
1325:C9
1320:C8
1315:B6
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