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Ceftazidime

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Ceftazidime is generally well tolerated. When side effects occur, they are most commonly local effects from the intravenous line site, allergic reactions, and gastrointestinal symptoms. According to one manufacturer, in clinical trials, allergic reactions including itching, rash, and fever, happened
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Ceftazidime is mainly eliminated by the kidneys into the urine. As such, drug levels in the blood may build up in persons with kidney injury or kidney disease. This includes those on dialysis. In these cases of renal impairment, the drug is dosed less frequently. No dose adjustment is needed for
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cephalosporins, some Gram-negative bacteria that produce extended-spectrum beta-lactamases (ESBLs) are even able to inactivate the third-generation cephalosporins. Infections caused by ESBL-producing Gram-negative bacteria are of particular concern in hospitals and other healthcare facilities.
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enzymes produced by Gram-negative bacteria. These bacterial enzymes rapidly destroy earlier-generation cephalosporins by breaking open the drug's beta-lactam chemical ring, leading to antibiotic resistance. Though initially active against these bacteria, with widespread use of third-generation
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As a class, cephalosporins have activity against Gram-positive and Gram-negative bacteria. The balance of activity tips toward Gram-positive organisms for earlier generations; later generations of cephalosporins have more Gram-negative coverage. Ceftazidime is one of the few in this class with
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According to the manufacturer, research studies in mice and rats showed no evidence of harm to the fetus, even at up to 40 times the human dose of ceftazidime. Importantly, though, no high-quality research studies of the effects of the drug in pregnant women were conducted.
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InChI=1S/C22H22N6O7S2/c1-22(2,20(33)34)35-26-13(12-10-37-21(23)24-12)16(29)25-14-17(30)28-15(19(31)32)11(9-36-18(14)28)8-27-6-4-3-5-7-27/h3-7,10,14,18H,8-9H2,1-2H3,(H4-,23,24,25,29,31,32,33,34)/b26-13-/t14-,18-/m1/s1
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White NJ, Dance DA, Chaowagul W, Wattanagoon Y, Wuthiekanun V, Pitakwatchara N (September 1989). "Halving of mortality of severe melioidosis by ceftazidime".
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However, what makes it unique from the rest of the cephalosporins is that it has coverage against methicillin-resistant Staphylococcus aureus (MRSA).
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bacteria. The extra stability to β-lactamases increases the activity of ceftazidime against otherwise resistant Gram-negative organisms including
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Richards DM, Brogden RN (February 1985). "Ceftazidime. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use".
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Richards DM, Brogden RN (February 1985). "Ceftazidime. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use".
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than first and second generation cephalosporins. Also. cephalosporins until fourth generation are not active against methicillin-resistant
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Ceftazidime is used to treat lower respiratory tract, skin, urinary tract, blood-stream, joint, and abdominal infections, and meningitis.
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Ceftazidime is contraindicated in people with a known allergy to ceftazidime or to any other cephalosporin antibiotic.
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moiety increases water-solubility. Ceftazidime shares the same variable R-group side chain with
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The following represents MIC susceptibility data for a few clinically significant pathogens:
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Third-generation cephalosporins differ from earlier generations in the presence of a C=N-OCH
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antibiotic; the two drugs share a similar spectrum of activity, including activity against
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but are only listed as class II). This group provides improved stability against certain
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Ceftazidime was patented in 1978 and came into commercial use in 1984. It is on the
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Another source reported, in addition, blood tests of patients may show increased
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in fewer than 2% of patients. Rare but more serious allergic reactions, such as
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Clinically relevant organisms against which ceftazidime has activity include:
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World Health Organization model list of essential medicines: 21st list 2019
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group) confers extra stability to beta-lactamase enzymes produced by many
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Insert into bacterial cell wall causing perforation and depolarization:
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Ceftazidime is the first-line treatment for the tropical infection,
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Ceftazidime generally has poor efficacy against anaerobes, such as
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family of medications and works by interfering with the bacteria's
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O=C2N1/C(=C(\CS12NC(=O)C(=NOC(C(=O)O)(C)C)c3nc(sc3)N)C4ccccc4)C()=O
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Journal of Hygiene, Epidemiology, Microbiology, and Immunology
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Ceftazidime for Injection(R) . Schaumburg, IL: Sagent; 2012.
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Labeled indications include the treatment of patients with:
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Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition
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World Health Organization's List of Essential Medicines
1785: 1288:"Tazicef- ceftazidime injection, powder, for solution" 893:, an important cause of sepsis in Asia and Australia. 3145: 2887:
Benzathine benzylpenicillin/procaine benzylpenicillin
1258:"Fortaz- ceftazidime injection, powder, for solution" 1205:. The American Society of Health-System Pharmacists. 100: 78: 66: 60: 1294:. U.S. National Library of Medicine. 24 March 2022. 84: 72: 1264:. U.S. National Library of Medicine. 28 July 2017. 1221: 90: 69: 774:among others, is a third-generation cephalosporin 1786:Sharma M, Pathak S, Srivastava P (October 2013). 3169: 461: 1714: 1687:. Treasure Island (FL): StatPearls Publishing. 1635: 1604: 1397: 436: 1050:(6%), or increased alkaline phosphatase (4%). 3198:World Health Organization essential medicines 1866: 1377:. Jones & Bartlett Learning. p. 87. 918:. However, ceftazidime is less effective for 190: 1321:(14th ed.). McGraw Hill. p. 803. 1873: 1859: 1197: 1195: 1193: 1191: 1189: 1187: 1185: 1183: 1181: 615: 592: 501: 2994:Inhibits PG elongation and crosslinking: 1811: 1678: 1461: 1459: 1457: 1455: 1453: 1441: 521: 1583:. Hudson, Ohio: Lexi-Drugs. April 2014. 1372: 778:useful for the treatment of a number of 1571: 1569: 1567: 1316: 1178: 929: 906:other Gram-negative, aerobic infections 588: 481: 146: 3170: 1450: 1422: 1404:. John Wiley & Sons. p. 495. 1366: 1079: 606: 164: 1854: 1484: 1436:. Geneva: World Health Organization. 1350:. American Academy of Ophthalmology. 1298:from the original on 28 December 2021 1268:from the original on 28 December 2021 1209:from the original on 20 December 2016 561: 541: 314: 181: 132: 1846:. U.S. National Library of Medicine. 1564: 1485:White NJ (May 2003). "Melioidosis". 1053: 851:. Its use is relatively safe during 832:Common side effects include nausea, 274: 1088:group in their chemical structure ( 452: 13: 1341: 1042:(thrombocythemia) (2%), increased 14: 3214: 3019:subunit synthesis and transport: 1832: 1354:from the original on 5 March 2021 1319:Basic & Clinical Pharmacology 301: 213: 3155: 1729:10.2165/00003495-198529020-00002 1650:10.2165/00003495-198529020-00002 1418:from the original on 2016-12-20. 974:, such as group B streptococci, 874:. Ceftazidime is available as a 646: 640: 56: 38: 29: 1779: 1751: 1708: 1672: 1629: 1598: 1587:from the original on 2014-04-23 1521: 1478: 1398:Fischer J, Ganellin CR (2006). 1009: 881: 739:Key:ORFOPKXBNMVMKC-DWVKKRMSSA-N 2917:Imipenem/cilastatin/relebactam 1391: 1335: 1310: 1280: 1250: 1061: 861:third-generation cephalosporin 782:. Specifically it is used for 658: 652: 634: 256:Third-generation cephalosporin 1: 1542:10.1016/S0140-6736(89)90768-X 1499:10.1016/S0140-6736(03)13374-0 1401:Analogue-based Drug Discovery 1171: 1108: 1070: 770:, sold under the brand name 7: 2942:Ticarcillin/clavulanic acid 2862:Amoxicillin/clavulanic acid 1999:Phenoxymethylpenicillin (V) 1989:Benzathine benzylpenicillin 1804:10.7860/JCDR/2013/6460.3462 1159: 10: 3219: 1067:those with liver disease. 1017:toxic epidermal necrolysis 624:Chemical and physical data 3178:Cephalosporin antibiotics 3106: 3058: 3008: 2987: 2963: 2954: 2867:Ampicillin/flucloxacillin 2854: 2794: 2761: 2729: 2711: 2683: 2650: 2515: 2422: 2334: 2313: 2247: 2213: 2184: 2151: 2092: 2081: 2032: 1994:Procaine benzylpenicillin 1972: 1961: 1947: 1905: 1679:Bui T, Preuss CV (2023). 1430:World Health Organization 1344:"Intravitreal Injections" 747: 722: 702: 680: 667: 628: 623: 604: 572: 552: 532: 512: 492: 472: 447: 427: 395: 390: 377: 364: 354: 340: 332: 291: 286: 261: 249: 227: 201: 154: 140: 122: 112: 51: 46: 37: 28: 1021:Stevens–Johnson syndrome 1005:: ≤0.03–1024 μg/mL 976:Streptococcus pneumoniae 804:malignant otitis externa 800:urinary tract infections 2932:Piperacillin/tazobactam 2892:Cefepime/enmetazobactam 1844:Drug Information Portal 118:Fortaz, Tazicef, others 3023:synthesis inhibition ( 2907:Ceftolozane/tazobactam 2897:Cefoperazone/sulbactam 2796:β-lactamase inhibitors 1605:O'Callaghan H (1986). 1154:Pseudomonas aeruginosa 1138:Pseudomonas aeruginosa 1117:-configuration of the 1003:Pseudomonas aeruginosa 999:: 0.015–512 μg/mL 980:Streptococcus pyogenes 967:Neisseria meningitidis 963:Pseudomonas aeruginosa 951:Haemophilus influenzae 916:Pseudomonas aeruginosa 901:Pseudomonas aeruginosa 809:Pseudomonas aeruginosa 2937:Sulbactam/durlobactam 2922:Meropenem/vaborbactam 2902:Ceftazidime/avibactam 2034:β-lactamase resistant 1974:β-lactamase sensitive 1166:Ceftazidime/avibactam 972:Gram-positive aerobes 939:Gram-negative aerobes 924:Staphylococcus aureus 839:Clostridium difficile 819:injection into a vein 18:Antibiotic medication 3188:Pyridinium compounds 2927:Panipenem/betamipron 2872:Ampicillin/sulbactam 1984:Benzylpenicillin (G) 1918:cell wall by binding 930:Spectrum of activity 780:bacterial infections 2912:Imipenem/cilastatin 2882:Aztreonam/avibactam 2693:Ceftaroline fosamil 1493:(9370): 1715–1722. 1373:Hamilton R (2015). 1113:In addition to the 1080:Mechanism of action 1025:erythema multiforme 310:(Prescription only) 25: 3133:Never to phase III 3065:Hydrolyze NAM-NAG 2153:Carboxypenicillins 1916:layer of bacterial 1912:(inhibit synthesis 1472:2014-04-23 at the 1317:Katzung B (2019). 876:generic medication 834:allergic reactions 21: 3143: 3142: 3004: 3003: 2950: 2949: 2757: 2756: 2539:Antipseudomonal ( 2447:Cefuroxime axetil 2243: 2242: 2239: 2238: 2186:Ureidopenicillins 2077: 2076: 1941: 1934: 1930: 1920:to and inhibiting 1536:(8665): 697–701. 1328:978-1-259-64115-2 1054:Contraindications 914:activity against 909:neutropenic fever 817:. It is given by 765: 764: 693:Interactive image 574:CompTox Dashboard 318: 305: 217: 184: 167: 3210: 3160: 3159: 3158: 3151: 2961: 2960: 2332: 2331: 2188:(4th generation) 2155:(4th generation) 2096:(3rd generation) 2094:Aminopenicillins 2090: 2089: 2037:(2nd generation) 1977:(1st generation) 1970: 1969: 1959: 1958: 1945: 1944: 1940: 1932: 1928: 1914:of peptidoglycan 1910: 1875: 1868: 1861: 1852: 1851: 1847: 1826: 1825: 1815: 1792:J Clin Diagn Res 1783: 1777: 1776: 1774: 1768:. Archived from 1763: 1755: 1749: 1748: 1712: 1706: 1705: 1700: 1699: 1681:"Cephalosporins" 1676: 1670: 1669: 1633: 1627: 1626: 1602: 1596: 1595: 1593: 1592: 1573: 1562: 1561: 1525: 1519: 1518: 1482: 1476: 1463: 1448: 1447: 1445: 1426: 1420: 1419: 1395: 1389: 1388: 1370: 1364: 1363: 1361: 1359: 1339: 1333: 1332: 1314: 1308: 1307: 1305: 1303: 1284: 1278: 1277: 1275: 1273: 1254: 1248: 1247: 1245: 1243: 1233:nctr-crs.fda.gov 1225: 1219: 1218: 1216: 1214: 1199: 1098:functional group 1046:(7%), increased 1038:(4%), increased 997:Escherichia coli 947:Escherichia coli 815:vibrio infection 784:joint infections 761: 760: 753: 695: 675: 660: 654: 648: 642: 636: 619: 608: 597: 596: 582: 580: 565: 545: 525: 505: 485: 465: 455: 454: 440: 369: 323: 316: 313: 303: 300: 278: 215: 212: 194: 183: 180: 177: 166: 163: 150: 136: 104: 97: 96: 93: 92: 89: 86: 83: 80: 77: 74: 71: 68: 65: 62: 42: 33: 26: 24: 20: 3218: 3217: 3213: 3212: 3211: 3209: 3208: 3207: 3168: 3167: 3166: 3156: 3154: 3146: 3144: 3139: 3138: 3123:Clinical trials 3102: 3054: 3000: 2983: 2946: 2850: 2823:Clavulanic acid 2790: 2753: 2725: 2707: 2679: 2646: 2511: 2418: 2325: 2321: 2317: 2309: 2267:Antipseudomonal 2235: 2209: 2180: 2147: 2084: 2073: 2036: 2028: 1976: 1964: 1937:transpeptidases 1936: 1926: 1921: 1919: 1917: 1915: 1913: 1911: 1909: 1901: 1879: 1838: 1835: 1830: 1829: 1784: 1780: 1772: 1761: 1757: 1756: 1752: 1713: 1709: 1697: 1695: 1677: 1673: 1634: 1630: 1603: 1599: 1590: 1588: 1581:Lexicomp Online 1575: 1574: 1565: 1526: 1522: 1483: 1479: 1474:Wayback Machine 1464: 1451: 1427: 1423: 1412: 1396: 1392: 1385: 1371: 1367: 1357: 1355: 1340: 1336: 1329: 1315: 1311: 1301: 1299: 1286: 1285: 1281: 1271: 1269: 1256: 1255: 1251: 1241: 1239: 1227: 1226: 1222: 1212: 1210: 1201: 1200: 1179: 1174: 1162: 1130:carboxylic acid 1111: 1096:also bear this 1087: 1082: 1073: 1064: 1056: 1012: 955:Klebsiella spp. 932: 884: 859:. It is in the 756: 754: 751:(what is this?) 748: 743: 740: 735: 730: 729: 718: 715: 710: 709: 698: 673: 663: 657: 651: 645: 639: 600: 576: 568: 548: 528: 508: 488: 468: 451: 443: 423: 420: 403: 402: 367: 342:Bioavailability 334:Pharmacokinetic 328: 321: 282: 230: 223: 204: 197: 102: 98: 59: 55: 19: 12: 11: 5: 3216: 3206: 3205: 3200: 3195: 3190: 3185: 3180: 3165: 3164: 3141: 3140: 3137: 3136: 3135: 3134: 3131: 3120: 3114: 3108: 3107: 3104: 3103: 3101: 3100: 3095: 3090: 3089: 3088: 3083: 3073: 3072: 3071: 3062: 3060: 3056: 3055: 3053: 3052: 3042: 3028: 3012: 3010: 3006: 3005: 3002: 3001: 2999: 2998: 2991: 2989: 2985: 2984: 2982: 2981: 2976: 2969: 2967: 2958: 2952: 2951: 2948: 2947: 2945: 2944: 2939: 2934: 2929: 2924: 2919: 2914: 2909: 2904: 2899: 2894: 2889: 2884: 2879: 2869: 2864: 2858: 2856: 2852: 2851: 2849: 2848: 2842: 2837: 2832: 2828:non-β-lactam ( 2826: 2816: 2810: 2800: 2798: 2792: 2791: 2789: 2788: 2783: 2778: 2773: 2767: 2765: 2759: 2758: 2755: 2754: 2752: 2751: 2746: 2741: 2735: 2733: 2727: 2726: 2724: 2723: 2717: 2715: 2709: 2708: 2706: 2705: 2700: 2695: 2689: 2687: 2685:5th generation 2681: 2680: 2678: 2677: 2672: 2667: 2662: 2656: 2654: 2652:4th generation 2648: 2647: 2645: 2644: 2638: 2629: 2624: 2619: 2614: 2609: 2604: 2599: 2594: 2589: 2584: 2579: 2574: 2569: 2564: 2559: 2554: 2549: 2543: 2537: 2532: 2527: 2521: 2519: 2517:3rd generation 2513: 2512: 2510: 2509: 2499: 2493: 2488: 2483: 2478: 2469: 2464: 2459: 2454: 2449: 2444: 2439: 2434: 2428: 2426: 2424:2nd generation 2420: 2419: 2417: 2416: 2411: 2406: 2401: 2396: 2391: 2386: 2381: 2376: 2371: 2366: 2361: 2356: 2351: 2346: 2340: 2338: 2336:1st generation 2329: 2319:Cephalosporins 2311: 2310: 2308: 2307: 2301: 2295: 2289: 2284: 2278: 2273: 2264: 2257: 2255: 2245: 2244: 2241: 2240: 2237: 2236: 2234: 2233: 2228: 2217: 2215: 2211: 2210: 2208: 2207: 2202: 2197: 2191: 2189: 2182: 2181: 2179: 2178: 2173: 2164: 2158: 2156: 2149: 2148: 2146: 2145: 2140: 2134: 2129: 2124: 2119: 2114: 2105: 2099: 2097: 2087: 2079: 2078: 2075: 2074: 2072: 2071: 2066: 2061: 2056: 2053:Flucloxacillin 2050: 2040: 2038: 2030: 2029: 2027: 2026: 2021: 2016: 2011: 2006: 2001: 1996: 1991: 1986: 1980: 1978: 1967: 1956: 1942: 1903: 1902: 1884:active on the 1882:Antibacterials 1878: 1877: 1870: 1863: 1855: 1849: 1848: 1834: 1833:External links 1831: 1828: 1827: 1798:(10): 2173–7. 1778: 1775:on 2014-12-04. 1750: 1723:(2): 105–161. 1707: 1671: 1644:(2): 105–161. 1628: 1617:(4): 449–453. 1597: 1563: 1520: 1477: 1449: 1421: 1410: 1390: 1383: 1365: 1334: 1327: 1309: 1279: 1249: 1220: 1176: 1175: 1173: 1170: 1169: 1168: 1161: 1158: 1140:. The charged 1110: 1107: 1102:beta-lactamase 1085: 1081: 1078: 1072: 1069: 1063: 1060: 1055: 1052: 1011: 1008: 1007: 1006: 1000: 983: 982: 969: 931: 928: 911: 910: 907: 904: 883: 880: 763: 762: 745: 744: 742: 741: 738: 736: 733: 725: 724: 723: 720: 719: 717: 716: 713: 705: 704: 703: 700: 699: 697: 696: 688: 686: 678: 677: 671: 665: 664: 661: 655: 649: 643: 637: 632: 626: 625: 621: 620: 610: 602: 601: 599: 598: 585: 583: 570: 569: 567: 566: 558: 556: 550: 549: 547: 546: 538: 536: 530: 529: 527: 526: 518: 516: 510: 509: 507: 506: 498: 496: 490: 489: 487: 486: 478: 476: 470: 469: 467: 466: 458: 456: 445: 444: 442: 441: 433: 431: 425: 424: 422: 421: 406: 398: 397: 396: 393: 392: 388: 387: 381: 375: 374: 371: 362: 361: 358: 352: 351: 344: 338: 337: 330: 329: 327: 326: 311: 297: 295: 289: 288: 284: 283: 281: 280: 267: 265: 259: 258: 253: 247: 246: 233: 231:administration 225: 224: 222: 221: 219: 209: 207: 199: 198: 196: 195: 178: 160: 158: 152: 151: 144: 138: 137: 130: 120: 119: 116: 110: 109: 53: 49: 48: 44: 43: 35: 34: 17: 9: 6: 4: 3: 2: 3215: 3204: 3201: 3199: 3196: 3194: 3191: 3189: 3186: 3184: 3181: 3179: 3176: 3175: 3173: 3163: 3153: 3152: 3149: 3132: 3130: 3127: 3126: 3124: 3121: 3118: 3115: 3113: 3110: 3109: 3105: 3099: 3096: 3094: 3091: 3087: 3084: 3082: 3079: 3078: 3077: 3074: 3070: 3067: 3066: 3064: 3063: 3061: 3057: 3050: 3046: 3043: 3040: 3036: 3032: 3029: 3026: 3022: 3018: 3014: 3013: 3011: 3009:Intracellular 3007: 2997: 2993: 2992: 2990: 2986: 2980: 2977: 2975: 2971: 2970: 2968: 2966: 2962: 2959: 2957: 2953: 2943: 2940: 2938: 2935: 2933: 2930: 2928: 2925: 2923: 2920: 2918: 2915: 2913: 2910: 2908: 2905: 2903: 2900: 2898: 2895: 2893: 2890: 2888: 2885: 2883: 2880: 2877: 2876:Sultamicillin 2873: 2870: 2868: 2865: 2863: 2860: 2859: 2857: 2853: 2846: 2843: 2841: 2838: 2836: 2833: 2831: 2827: 2824: 2820: 2817: 2814: 2811: 2809: 2805: 2802: 2801: 2799: 2797: 2793: 2787: 2784: 2782: 2779: 2777: 2774: 2772: 2769: 2768: 2766: 2764: 2760: 2750: 2747: 2745: 2742: 2740: 2737: 2736: 2734: 2732: 2728: 2722: 2719: 2718: 2716: 2714: 2710: 2704: 2701: 2699: 2696: 2694: 2691: 2690: 2688: 2686: 2682: 2676: 2673: 2671: 2668: 2666: 2663: 2661: 2658: 2657: 2655: 2653: 2649: 2642: 2639: 2637: 2633: 2630: 2628: 2625: 2623: 2620: 2618: 2615: 2613: 2610: 2608: 2605: 2603: 2600: 2598: 2595: 2593: 2590: 2588: 2585: 2583: 2580: 2578: 2575: 2573: 2570: 2568: 2565: 2563: 2560: 2558: 2555: 2553: 2550: 2547: 2544: 2542: 2538: 2536: 2533: 2531: 2528: 2526: 2523: 2522: 2520: 2518: 2514: 2507: 2503: 2500: 2497: 2494: 2492: 2491:Cefbuperazone 2489: 2487: 2484: 2482: 2479: 2477: 2473: 2470: 2468: 2465: 2463: 2460: 2458: 2455: 2453: 2450: 2448: 2445: 2443: 2440: 2438: 2435: 2433: 2430: 2429: 2427: 2425: 2421: 2415: 2412: 2410: 2407: 2405: 2402: 2400: 2397: 2395: 2392: 2390: 2387: 2385: 2382: 2380: 2377: 2375: 2372: 2370: 2367: 2365: 2362: 2360: 2357: 2355: 2352: 2350: 2347: 2345: 2342: 2341: 2339: 2337: 2333: 2330: 2328: 2324: 2320: 2316: 2312: 2305: 2302: 2300: 2296: 2293: 2290: 2288: 2285: 2282: 2279: 2277: 2274: 2272: 2268: 2265: 2263: 2260:Carbapenems ( 2259: 2258: 2256: 2254: 2250: 2246: 2232: 2231:Sulbenicillin 2229: 2226: 2225:Pivmecillinam 2222: 2219: 2218: 2216: 2212: 2206: 2203: 2201: 2198: 2196: 2193: 2192: 2190: 2187: 2183: 2177: 2174: 2172: 2171:Carindacillin 2168: 2167:Carbenicillin 2165: 2163: 2160: 2159: 2157: 2154: 2150: 2144: 2141: 2138: 2137:Talampicillin 2135: 2133: 2132:Metampicillin 2130: 2128: 2127:Lenampicillin 2125: 2123: 2122:Bacampicillin 2120: 2118: 2115: 2113: 2112:Pivampicillin 2109: 2106: 2104: 2101: 2100: 2098: 2095: 2091: 2088: 2086: 2080: 2070: 2067: 2065: 2062: 2060: 2057: 2054: 2051: 2049: 2048:Dicloxacillin 2045: 2042: 2041: 2039: 2035: 2031: 2025: 2022: 2020: 2019:Clometocillin 2017: 2015: 2012: 2010: 2009:Pheneticillin 2007: 2005: 2002: 2000: 1997: 1995: 1992: 1990: 1987: 1985: 1982: 1981: 1979: 1975: 1971: 1968: 1966: 1960: 1957: 1954: 1950: 1946: 1943: 1938: 1924: 1908: 1904: 1899: 1895: 1891: 1887: 1883: 1876: 1871: 1869: 1864: 1862: 1857: 1856: 1853: 1845: 1841: 1840:"Ceftazidime" 1837: 1836: 1823: 1819: 1814: 1809: 1805: 1801: 1797: 1793: 1789: 1782: 1771: 1767: 1760: 1754: 1746: 1742: 1738: 1734: 1730: 1726: 1722: 1718: 1711: 1704: 1694: 1690: 1686: 1682: 1675: 1667: 1663: 1659: 1655: 1651: 1647: 1643: 1639: 1632: 1624: 1620: 1616: 1612: 1608: 1601: 1586: 1582: 1578: 1577:"Ceftazidime" 1572: 1570: 1568: 1559: 1555: 1551: 1547: 1543: 1539: 1535: 1531: 1524: 1516: 1512: 1508: 1504: 1500: 1496: 1492: 1488: 1481: 1475: 1471: 1468: 1467:PDF of insert 1462: 1460: 1458: 1456: 1454: 1444: 1439: 1435: 1431: 1425: 1417: 1413: 1411:9783527607495 1407: 1403: 1402: 1394: 1386: 1384:9781284057560 1380: 1376: 1369: 1353: 1349: 1345: 1338: 1330: 1324: 1320: 1313: 1297: 1293: 1289: 1283: 1267: 1263: 1259: 1253: 1238: 1234: 1230: 1224: 1208: 1204: 1203:"Ceftazidime" 1198: 1196: 1194: 1192: 1190: 1188: 1186: 1184: 1182: 1177: 1167: 1164: 1163: 1157: 1155: 1151: 1147: 1143: 1139: 1135: 1134:Gram-negative 1131: 1127: 1123: 1120: 1116: 1106: 1103: 1099: 1095: 1091: 1077: 1068: 1059: 1051: 1049: 1045: 1041: 1037: 1033: 1028: 1026: 1022: 1018: 1004: 1001: 998: 995: 994: 993: 990: 988: 981: 977: 973: 970: 968: 964: 960: 956: 952: 948: 944: 940: 937: 936: 935: 927: 925: 921: 917: 908: 905: 902: 899: 898: 897: 894: 892: 887: 879: 877: 873: 868: 866: 862: 858: 857:breastfeeding 854: 850: 846: 842: 840: 835: 830: 828: 824: 820: 816: 812: 810: 805: 801: 797: 793: 789: 785: 781: 777: 773: 769: 759: 752: 746: 737: 732: 731: 728: 721: 712: 711: 708: 701: 694: 690: 689: 687: 684: 679: 672: 670: 666: 633: 631: 627: 622: 618: 614: 611: 609: 607:ECHA InfoCard 603: 595: 591: 590:DTXSID5022770 587: 586: 584: 575: 571: 564: 560: 559: 557: 555: 551: 544: 540: 539: 537: 535: 531: 524: 520: 519: 517: 515: 511: 504: 500: 499: 497: 495: 491: 484: 480: 479: 477: 475: 471: 464: 460: 459: 457: 450: 446: 439: 435: 434: 432: 430: 426: 418: 414: 410: 405: 404: 401: 394: 389: 386: 382: 380: 376: 372: 370: 363: 359: 357: 353: 349: 345: 343: 339: 335: 331: 324: 312: 309: 299: 298: 296: 294: 290: 285: 277: 272: 269: 268: 266: 264: 260: 257: 254: 252: 248: 245: 241: 240:intramuscular 237: 234: 232: 226: 220: 211: 210: 208: 206: 200: 193: 188: 179: 176: 171: 162: 161: 159: 157: 153: 149: 145: 143: 139: 135: 131: 129: 125: 121: 117: 115: 111: 107: 106: 95: 54: 52:Pronunciation 50: 47:Clinical data 45: 41: 36: 32: 27: 16: 3203:Oxime ethers 3047:inhibitors ( 3037:inhibitors ( 2965:Lipopeptides 2956:Polypeptides 2855:Combinations 2786:Nocardicin A 2703:Ceftobiprole 2546:Cefoperazone 2540: 2404:Cefaloridine 2389:Cefaloglycin 2327:Carbacephems 2195:Piperacillin 2024:Penamecillin 1925:, a group of 1843: 1795: 1791: 1781: 1770:the original 1765: 1753: 1720: 1716: 1710: 1702: 1696:. Retrieved 1684: 1674: 1641: 1637: 1631: 1614: 1610: 1600: 1589:. Retrieved 1580: 1533: 1529: 1523: 1490: 1486: 1480: 1443:10665/325771 1433: 1424: 1400: 1393: 1374: 1368: 1356:. Retrieved 1347: 1337: 1318: 1312: 1300:. Retrieved 1291: 1282: 1270:. Retrieved 1261: 1252: 1240:. Retrieved 1232: 1223: 1211:. Retrieved 1153: 1137: 1114: 1112: 1083: 1074: 1065: 1057: 1029: 1013: 1010:Side effects 1002: 996: 991: 986: 984: 979: 975: 971: 966: 962: 959:Proteus spp. 958: 954: 950: 946: 943:Enterobacter 942: 938: 933: 923: 919: 915: 912: 900: 895: 888: 885: 882:Medical uses 869: 838: 831: 808: 771: 767: 766: 755:   749:   416: 412: 408: 366:Elimination 293:Legal status 287:Legal status 156:License data 15: 3193:Zwitterions 3119:from market 3098:Teixobactin 3076:Tyrothricin 3045:bactoprenol 3039:Cycloserine 2845:Vaborbactam 2835:Durlobactam 2763:Monobactams 2721:Cefiderocol 2713:Siderophore 2698:Ceftolozane 2612:Cefpimizole 2582:Cefpodoxime 2577:Cefpiramide 2572:Cefmenoxime 2567:Ceftizoxime 2562:Cefdaloxime 2541:Ceftazidime 2530:Ceftriaxone 2502:Carbacephem 2496:Cefmetazole 2452:Cefamandole 2414:Cefatrizine 2394:Cefacetrile 2379:Cefroxadine 2323:Cephamycins 2249:Carbapenems 2205:Mezlocillin 2162:Ticarcillin 2103:Amoxicillin 2069:Methicillin 2044:Cloxacillin 2014:Azidocillin 2004:Propicillin 1949:Penicillins 1062:Precautions 1036:Coombs test 1032:eosinophils 987:Bacteroides 891:melioidosis 845:anaphylaxis 768:Ceftazidime 676: g·mol 613:100.069.720 563:ChEMBL44354 391:Identifiers 373:1.6–2 hours 236:Intravenous 192:Ceftazidime 142:MedlinePlus 114:Trade names 23:Ceftazidime 3172:Categories 3086:Tyrocidine 3081:Gramicidin 3049:Bacitracin 3025:Fosfomycin 2996:Ramoplanin 2974:Daptomycin 2840:Relebactam 2813:Tazobactam 2744:Cefquinome 2731:Veterinary 2675:Cefquinome 2665:Cefozopran 2627:Ceftiolene 2617:Cefsulodin 2607:Cefodizime 2592:Cefditoren 2587:Ceftibuten 2535:Cefotaxime 2506:Loracarbef 2472:Cephamycin 2462:Ceforanide 2442:Cefuroxime 2399:Cefalonium 2369:Cefazaflur 2364:Cefazedone 2354:Cefadroxil 2221:Mecillinam 2200:Azlocillin 2176:Temocillin 2117:Hetacillin 2108:Ampicillin 1698:2023-04-13 1685:StatPearls 1591:2014-04-21 1358:12 January 1342:Kamjoo S. 1213:8 December 1172:References 1150:monobactam 1142:pyridinium 1122:side chain 1090:cefuroxime 903:infections 849:penicillin 788:meningitis 776:antibiotic 681:3D model ( 669:Molar mass 543:CHEBI:3508 523:DZR1ENT301 494:ChemSpider 438:72558-82-8 429:CAS Number 400:IUPAC name 360:negligible 356:Metabolism 251:Drug class 244:inhalation 3183:Thiazoles 3129:Phase III 3117:Withdrawn 3093:Isoniazid 2979:Surfactin 2830:Avibactam 2808:Sulbactam 2781:Carumonam 2776:Tigemonam 2771:Aztreonam 2749:Cefovecin 2739:Ceftiofur 2670:Cefpirome 2641:Latamoxef 2632:Oxacephem 2602:Cefetamet 2557:Cefcapene 2481:Cefotetan 2476:Cefoxitin 2467:Cefuzonam 2457:Cefonicid 2437:Cefprozil 2409:Cefalotin 2384:Ceftezole 2374:Cefradine 2359:Cefapirin 2349:Cefalexin 2344:Cefazolin 2304:Ritipenem 2299:Faropenem 2292:Panipenem 2281:Meropenem 2271:Doripenem 2262:Ertapenem 2143:Epicillin 2064:Nafcillin 2059:Oxacillin 1907:β-lactams 1886:cell wall 1745:265707490 1666:265707490 1515:208790913 1146:aztreonam 1109:Chemistry 1094:cefuzonam 1071:Pregnancy 1040:platelets 920:S. aureus 865:cell wall 853:pregnancy 811:infection 792:pneumonia 379:Excretion 368:half-life 229:Routes of 203:Pregnancy 134:Monograph 128:Drugs.com 3162:Medicine 3069:lysozyme 3015:Inhibit 2660:Cefepime 2636:Flomoxef 2622:Cefteram 2597:Cefotiam 2552:Cefdinir 2525:Cefixime 2486:Cefminox 2432:Cefaclor 2297:Penems ( 2287:Biapenem 2276:Imipenem 2085:spectrum 2083:Extended 1965:spectrum 1935:-alanine 1931:-alanyl- 1890:envelope 1822:24298468 1693:31855361 1585:Archived 1558:28919574 1507:12767750 1470:Archived 1432:(2019). 1416:Archived 1352:Archived 1296:Archived 1292:DailyMed 1266:Archived 1262:DailyMed 1207:Archived 1160:See also 941:such as 841:diarrhea 758:(verify) 474:DrugBank 263:ATC code 218: B1 205:category 187:DailyMed 2315:Cephems 1813:3843424 1737:3884319 1658:3884319 1623:3100612 1550:2570956 1348:EyeWiki 1302:12 June 1272:12 June 630:Formula 503:4587145 483:DB00438 463:5481173 449:PubChem 383:90–96% 325:Rx-only 322:WARNING 279:) 273: ( 271:J01DD02 189::  172::  148:a686007 105:-i-deem 3148:Portal 3112:WHO-EM 2819:Clavam 2253:Penems 1963:Narrow 1953:Penams 1820:  1810:  1766:Toku-e 1743:  1735:  1691:  1664:  1656:  1621:  1556:  1548:  1530:Lancet 1513:  1505:  1487:Lancet 1408:  1381:  1325:  1242:22 Oct 1128:and a 1126:methyl 1092:& 1023:, and 978:, and 965:, and 823:muscle 813:, and 796:sepsis 772:Fortaz 707:SMILES 674:546.57 554:ChEMBL 385:kidney 319: 306: 185:  175:by INN 168:  108: 3059:Other 3031:DADAL 2988:Other 2804:Penam 2214:Other 1773:(PDF) 1762:(PDF) 1741:S2CID 1717:Drugs 1662:S2CID 1638:Drugs 1554:S2CID 1511:S2CID 1119:imino 989:spp. 847:to a 825:, or 727:InChI 683:JSmol 534:ChEBI 346:91% ( 1923:PBPs 1898:J01D 1894:J01C 1888:and 1818:PMID 1733:PMID 1689:PMID 1654:PMID 1619:PMID 1546:PMID 1503:PMID 1406:ISBN 1379:ISBN 1360:2020 1323:ISBN 1304:2022 1274:2022 1244:2023 1215:2016 1148:, a 855:and 514:UNII 336:data 124:AHFS 101:sef- 3021:NAM 1808:PMC 1800:doi 1725:doi 1646:doi 1538:doi 1495:doi 1491:361 1438:hdl 1237:FDA 1115:syn 1048:AST 1044:ALT 827:eye 579:EPA 453:CID 276:WHO 170:EMA 103:TAZ 3174:: 3125:: 3035:AR 3017:PG 2251:/ 2169:/ 1842:. 1816:. 1806:. 1794:. 1790:. 1764:. 1739:. 1731:. 1721:29 1719:. 1701:. 1683:. 1660:. 1652:. 1642:29 1640:. 1615:30 1613:. 1609:. 1579:. 1566:^ 1552:. 1544:. 1532:. 1509:. 1501:. 1489:. 1452:^ 1414:. 1346:. 1290:. 1260:. 1235:. 1231:. 1180:^ 1156:. 1019:, 961:, 957:, 953:, 949:, 945:, 926:. 878:. 867:. 829:. 821:, 806:, 802:, 798:, 794:, 790:, 786:, 644:22 638:22 411:,7 407:(6 348:IM 315:US 308:S4 302:AU 242:, 238:, 214:AU 182:US 165:EU 88:iː 3150:: 3051:) 3041:) 3033:/ 3027:) 2878:) 2874:( 2847:) 2825:) 2821:( 2815:) 2806:( 2643:) 2634:( 2548:) 2508:) 2504:( 2498:) 2474:( 2306:) 2294:) 2283:) 2269:( 2227:) 2223:( 2139:) 2110:( 2055:) 2046:( 1955:) 1951:( 1939:) 1933:D 1929:D 1900:) 1896:- 1892:( 1874:e 1867:t 1860:v 1824:. 1802:: 1796:7 1747:. 1727:: 1668:. 1648:: 1625:. 1594:. 1560:. 1540:: 1534:2 1517:. 1497:: 1440:: 1387:. 1362:. 1331:. 1306:. 1276:. 1246:. 1217:. 1086:3 685:) 662:2 659:S 656:7 653:O 650:6 647:N 641:H 635:C 581:) 577:( 417:Z 415:, 413:R 409:R 350:) 317:: 304:: 216:: 126:/ 94:/ 91:m 85:d 82:ɪ 79:z 76:æ 73:t 70:ˈ 67:f 64:ɛ 61:s 58:/

Index



/sɛfˈtæzɪdm/
sef-TAZ-i-deem
Trade names
AHFS
Drugs.com
Monograph
MedlinePlus
a686007
License data
EMA
by INN
DailyMed
Ceftazidime
Pregnancy
category

Routes of
administration

Intravenous
intramuscular
inhalation
Drug class
Third-generation cephalosporin
ATC code
J01DD02
WHO
Legal status
S4
WARNING
Pharmacokinetic
Bioavailability

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