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Medical microbiology

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1001:, viruses that only infect bacteria, can specifically target the bacteria of interest and inject their genome. This process makes the bacteria halt its own production to make more phages, and this continues until the bacteria lyses itself and releases the phages into the surrounding environment. Phage therapy does not kill microbiota since it is specific, and it can help those with antibiotic allergies. Some drawbacks are that it is a time-intensive process since the specific bacterium needs to be identified. It also does not currently have the body of research supporting its effects and safety that antibiotics do. Bacteria can also eventually become resistant, through systems like CRISPR/Cas9 system. Many clinical trials have been promising though, showing that it could potentially help with the antimicrobial resistance problem. It can also be used in conjunction with antibiotics for a cumulative effect. 152: 692: 948: 163: 4189: 4219: 4229: 4209: 4199: 92:, their modes of transmission, mechanisms of infection and growth. The academic qualification as a clinical/Medical Microbiologist in a hospital or medical research centre generally requires a Bachelors degree while in some countries a Masters in Microbiology along with Ph.D. in any of the life-sciences (Biochem, Micro, Biotech, Genetics, etc.). Medical microbiologists often serve as consultants for 828:. The antigen (usually a protein or carbohydrate made by an infectious agent) is bound by the antibody, allowing this type of test to be used for organisms other than bacteria. This binding then sets off a chain of events that can be easily and definitively observed, depending on the test. More complex serological techniques are known as 814:, as mentioned above. In order to perform these tests en masse, automated machines are used. These machines perform multiple biochemical tests simultaneously, using cards with several wells containing different dehydrated chemicals. The microbe of interest will react with each chemical in a specific way, aiding in its identification. 781:
reads the electrons that are reflected off the surface of the cells. A 3-dimensional image is then made which shows the size and exterior structure of the cells. Both techniques help give more detailed information about the structure of microbes. This makes it useful in many medical fields, such as
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conditions in populations, is an important part of medical microbiology, although the clinical aspect of the field primarily focuses on the presence and growth of microbial infections in individuals, their effects on the human body, and the methods of treating those infections. In this respect the
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Medical microbiology is not only about diagnosing and treating disease, it also involves the study of beneficial microbes. Microbes have been shown to be helpful in combating infectious disease and promoting health. Treatments can be developed from microbes, as demonstrated by Alexander Fleming's
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also removes the risk of contamination that can occur during standard PCR procedures (carrying over PCR product into subsequent PCRs). Another advantage of using PCR to detect and study microbes is that the DNA sequences of newly discovered infectious microbes or strains can be compared to those
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and skin infections. In order to make an educated estimate as to which microbe could be causing the disease, epidemiological factors need to be considered; such as the patient's likelihood of exposure to the suspected organism and the presence and prevalence of a microbial strain in a community.
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for other cells to adhere to. This provides them with a stable environment from which the bacteria can disperse and infect other parts of the host. Additionally, the extracellular matrix and dense outer layer of bacterial cells can protect the inner bacteria cells from antimicrobial drugs.
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as adaptive immunity to phages. The system was then quickly found to be able to help in genome editing through its ability to generate double strand breaks. A patient with sickle cell disease was the first person to be treated for a genetic disorder with CRISPR in July 2019.
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of an organism may be resistant to a certain drug or class of drug, even when it is typically effective against the species. These strains, termed resistant strains, present a serious public health concern of growing importance to the medical industry as the spread of
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already listed in databases, which in turn helps to increase understanding of which organism is causing the infectious disease and thus what possible methods of treatment could be used. This technique is the current standard for detecting viral infections such as
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Taguchi T, Yabe M, Odaki H, Shinozaki M, Metsä-Ketelä M, Arai T, Okamoto S, Ichinose K (2013) Biosynthetic Conclusions from the Functional Dissection of Oxygenases for Biosynthesis of Actinorhodin and Related Streptomyces Antibiotics. Chemistry & Biology
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passes electrons through a thin cross-section of the cell of interest, and it then redirects the electrons onto a fluorescent screen. This method is useful for looking at the inside of cells, and the structures within, especially cell walls and membranes.
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can be used to assess critical aspects of the organism. This can be performed immediately after the sample is taken from the patient and is used in conjunction with biochemical staining techniques, allowing for resolution of cellular features.
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Like other pathogens, viruses use these methods of transmission to enter the body, but viruses differ in that they must also enter into the host's actual cells. Once the virus has gained access to the host's cells, the virus' genetic material
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Michaleas, Spyros N.; Laios, Konstantinos; Charalabopoulos, Alexandros; Samonis, George; Karamanou, Marianna; Michaleas, Spyridon; Laios, Konstantinos; Charalabopoulos, Alexandros; Samonis, George; Karamanou, Marianna (2022-12-21).
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Whilst drug resistance typically involves microbes chemically inactivating an antimicrobial drug or a cell mechanically stopping the uptake of a drug, another form of drug resistance can arise from the formation of
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Antibiotic resistance tests: bacteria in the culture on the left are sensitive to the antibiotics contained in the white, paper discs. Bacteria in the culture on the right are resistant to most of the antibiotics.
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of organism, and will not work on other organisms. Because of this specificity, medical microbiologists must consider the effectiveness of certain antimicrobial drugs when making recommendations. Additionally,
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Once an infection has been diagnosed and identified, suitable treatment options must be assessed by the physician and consulting medical microbiologists. Some infections can be dealt with by the body's own
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is a technique that was discovered before antibiotics, but fell to the wayside as antibiotics became predominate. It is now being considered as a potential solution to increasing antimicrobial resistance.
729:. A single microbe on an agar plate can then grow into colonies (clones where cells are identical to each other) containing thousands of cells. These are primarily used to culture bacteria and fungi. 1442:
Fleischmann R, Adams M, White O, Clayton R, Kirkness E, Kerlavage A, Bult C, Tomb J, Dougherty B, Merrick J, al. e (1995) Whole-genome random sequencing and assembly of Haemophilus influenzae Rd"
843:(PCR) assays are the most commonly used molecular technique to detect and study microbes. As compared to other methods, sequencing and analysis is definitive, reliable, accurate, and fast. Today, 832:. Using a similar basis as described above, immunoassays can detect or measure antigens from either infectious agents or the proteins generated by an infected host in response to the infection. 782:
diagnostics and biopsies of many body parts, hygiene, and virology. They provide critical information about the structure of pathogens, which allow physicians to treat them with more knowledge.
610:. Replication between viruses is greatly varied and depends on the type of genes involved in them. Most DNA viruses assemble in the nucleus while most RNA viruses develop solely in cytoplasm. 651:
Diagnosis of infectious disease is nearly always initiated by consulting the patient's medical history and conducting a physical examination. More detailed identification techniques involve
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are also used for observing microbes in greater detail for research. The two main types of electron microscopy are scanning electron microscopy and transmission electron microscopy.
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methods are highly sensitive, specific and often extremely rapid laboratory tests used to identify different types of microorganisms. The tests are based upon the ability of an
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are infected with the microbe of interest. These cultures are then observed to determine the effect the microbe has on the cells. This technique is used for identifying viruses.
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entire field, as an applied science, can be conceptually subdivided into academic and clinical sub-specialties, although in reality there is a fluid continuum between
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is the primary technique used, as this method provides faster data compared to a standard PCR assay. For instance, traditional PCR techniques require the use of
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The mechanisms for infection, proliferation, and persistence of a virus in cells of the host are crucial for its survival. For example, some diseases such as
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Vickery K, Hu H, Jacombs AS, Bradshaw DA, Deva AK (2013) A review of bacterial biofilms and their role in device-associated infection. Healthcare Infection .
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or resistant strains of microbes, educating the community and assisting in the design of health practices. They may also assist in preventing or controlling
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Kappus KD; Lundgren RG Jr.; Juranek DD; Roberts JM; et al. (June 1994). "Intestinal parasitism in the United States: update on a continuing problem".
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is the primary method used for isolating infectious disease for study in the laboratory. Tissue or fluid samples are tested for the presence of a specific
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developed the method of staining bacteria to make them more visible and differentiated under a microscope. This technique is widely used today.
2461: 1511: 254:, a certain microorganism being responsible for a certain disease. He developed a series of criteria around this that have become known as the 57:. In addition, this field of science studies various clinical applications of microbes for the improvement of health. There are four kinds of 1792: 1666: 2756: 985:. Some bacteria are able to form biofilms by adhering to surfaces on implanted devices such as catheters and prostheses and creating an 3718: 512:. The pathogen that causes the disease may be exogenous (acquired from an external source; environmental, animal or other people, e.g. 1817: 617:
employ a strategy whereby it must spread to a series of hosts. In these forms of viral infection, the illness is often treated by the
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Liquid culture: Cells are grown inside a liquid media. Microbial growth is determined by the time taken for the liquid to form a
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In addition to drugs being specific to a certain kind of organism (bacteria, fungi, etc.), some drugs are specific to a certain
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provided much insight into infectious diseases. He was one of the first scientists to focus on the isolation of bacteria in
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Frank N. Egerton (2006). "A History of the Ecological Sciences, Part 19: Leeuwenhoek's Microscopic Natural History".
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to provide health benefits to the host, such as providing better gastrointestinal health or inhibiting pathogens.
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Medical microbiologists often make treatment recommendations to the patient's physician based on the strain of
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Identification of an infectious agent for a minor illness can be as simple as clinical presentation; such as
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will often use a microscopic examination to help in the identification of the microbe. Instruments such as
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and using it to clean wounds, post-operative infections were reduced, making surgery safer for patients.
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without toxicity. Domagk received the Nobel Prize in physiology, or medicine, for the discovery of the
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The site at which a microbe enters the body is referred to as the portal of entry. These include the
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Siebeling, RJ (1998). "Principles of bacterial pathogenesis". In Bittar, E; Neville, EB (eds.).
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among many others. Not only are microorganisms a source of antibiotics but some may also act as
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There are various ways in which disease can be transmitted between individuals. These include:
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to successfully immunize a child against smallpox. The same principles are used for developing
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In 2007, a team at the Danish food company Danisco, were able to identify the purpose of the
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Sanger F, Nicklen S, Coulson AR (1977) DNA sequencing with chain-terminating inhibitors"
1390: 894: 848: 621:, and therefore the virus is required to disperse to new hosts before it is destroyed by 532: 396: 266: 2362: 2183:"Safe inoculation of blood and bone marrow for liquid culture detection of mycobacteria" 2062: 947: 291:
developed one of the most commonly used antibiotic substances both at the time and now:
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Williams NT (2010) Probiotics. American Journal of Health-System Pharmacy 67:449-458.
2382: 2301: 2276: 2248: 2204: 2161: 2135: 2086: 2023: 2013: 1975: 1944: 1912: 1902: 1867: 1859: 1745: 1710: 1644: 1556: 1495: 1369: 1335: 1327: 1290: 1264: 1246: 1202: 1179: 1161: 1095: 1064: 1035:"The Clinical Microbiology Laboratory Director in the United States Hospital Setting" 652: 607: 524: 454: 435: 385: 288: 221: 170:, father of medical bacteriology, at Robert-Koch-Platz (Robert Koch square) in Berlin 2394: 1879: 1347: 1323: 1010: 794:
can be used to identify infectious agents. For bacterial identification, the use of
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Prescott LM, Harley JP, Klein DA (2005) Microbiology: McGraw-Hill Higher Education.
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Dennehy PH (2012). "Rotavirus infection: an update on management and prevention".
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is an increasingly problematic issue that leads to millions of deaths every year.
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Solid culture: A solid surface is created using a mixture of nutrients, salts and
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tested multiple combinations of arsenic based chemicals on infected rabbits with
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Proceedings of the National Academy of Sciences of the United States of America
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Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und Verwandte Gebiete
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to detect the DNA molecules as they are being amplified. In addition to this,
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Madigan MT (2009) Brock Biology of Microorganisms: Pearson/Benjamin Cummings.
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genome was completed. This would prove invaluable for diagnostic techniques.
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Roberts RJ, "Fish pathology, 3rd Edition", Elsevier Health Sciences, 2001.
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and outbreaks of disease. Not all medical microbiologists study microbial
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or enzymatic characteristics are common due to their ability to ferment
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as well as the development of new antibiotics from the bacterial genus
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to visualize amplified DNA molecules after the reaction has finished.
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and the first genetically engineered vaccine was created in 1986 for
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A microbiologist examining cultures under a dissecting microscope.
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Real-time PCR in Microbiology: From Diagnosis to Characterisation
2012:(4th ed.). University of Texas Medical Branch at Galveston. 1901:(4th ed.). University of Texas Medical Branch at Galveston. 982: 960: 929: 902: 825: 807: 614: 485: 441: 337: 333: 209: 205: 123: 1689:"Prevalence of HPV infection among females in the United States" 736:. This technique is used for diagnosing parasites and detecting 178:
observed bacteria and other microorganisms, using a single-lens
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Møller M; El Maghrabi R; Olesen N; Thomsen VØ (November 2004).
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or host death. In contrast, some infectious agents such as the
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Greggs WM; Clouser CL; Patterson SE; Manksy LM (April 2012).
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was the first to observe microorganisms using a microscope.
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depends on continual improvements in academic medicine and
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Nester E; Anderson D; Evans Roberts, C; Nester M (2009).
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Willey, Joanne; Sandman, Kathleen; Wood, Dorothy (2020).
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Thomson, R. B.; Wilson, M. L.; Weinstein, M. P. (2010).
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also designed vaccines against several diseases such as
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Direct contact - Touching an infected host, including
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The American Journal of Tropical Medicine and Hygiene
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surgery. By sterilizing the instruments with diluted
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does not require this, as the detection system uses
118:, the study of the patterns, causes, and effects of 1196: 1837: 1687:Dunne EF; Unger ER; Sternberg, M (February 2007). 1201:(13th ed.). Pearson Education. p. 1096. 556:Indirect contact - Touching a contaminated surface 332:in 1977, caused a rapid change the development of 2295: 1838:Nenoff, P.; Krüger, C.; Mayser, P. (2015-06-01). 1474:Shaikh N; Leonard E; Martin JM (September 2010). 1363: 261:A major milestone in medical microbiology is the 4245: 1368:. New York: McGraw-Hill Education. p. 188. 1287:Robert Koch: a life in medicine and bacteriology 1112: 721:The 3 main types of media used for testing are: 2363:"Antibiotic resistance of bacteria in biofilms" 1431:Proceedings of the National Academy of Sciences 1146:Proceedings (Baylor University. Medical Center) 889:, but more serious infections are treated with 2271:Viljoen GJ; Nel LH; Crowther JR, eds. (2005). 1816:. Centers for Disease Control and Prevention. 1791:. Centers for Disease Control and Prevention. 1766:. Centers for Disease Control and Prevention. 917:respectively. A broad class of drugs known as 568:- Ingesting contaminated food or water sources 486:Causes and transmission of infectious diseases 3430: 3006: 2462: 2230:(Boseck 1982) (Slonczewski & Foster 2017) 1115:Bulletin of the Ecological Society of America 589:Environmental - Hospital-acquired infection ( 1620: 835: 77:, and one type of infectious protein called 2300:. Oxford Academic Press. pp. 308–320. 2247:. Horizon Scientific Press. pp. 1–25. 1693:Journal of the American Medical Association 1577:. World Health Organization. Archived from 1464:(Stein 2019) (Barrangou & Horvath 2017) 3719:Reproductive endocrinology and infertility 3437: 3423: 3013: 2999: 2469: 2455: 2266: 2264: 2044: 1892: 1626: 571:Airborne transmission - Pathogen carrying 4060:Bachelor of Medicine, Bachelor of Surgery 2238: 2236: 2198: 2151: 2149: 2129: 2080: 2070: 1970:. Jones & Bartlett Learning. p.  1957: 1938: 1934: 1932: 1930: 1704: 1550: 1414: 1258: 1240: 1173: 1081: 1058: 2314: 2242: 2038: 1281: 946: 690: 667:. Other less common techniques (such as 516:) or endogenous (from normal flora e.g. 161: 150: 29: 2261: 2003: 1597: 1595: 936:, the site of infection, the potential 14: 4246: 2361:Stewart PS; Costerton JW (July 2001). 2233: 2174: 2146: 2097: 1997: 1927: 1721: 1467: 1388: 1139: 3418: 2994: 2450: 1886: 1680: 1524: 1309: 4198: 3959:Physical medicine and rehabilitation 2289: 1806: 1781: 1756: 1655: 1592: 1525:Vos T; et al. (December 2012). 1359: 1357: 1197:Madigan M; Martinko J, eds. (2006). 1190: 802:in patterns characteristic of their 785: 686: 381:Commonly treated infectious diseases 4208: 2762:Oxidative/fermentation glucose test 2320: 1567: 1518: 901:(often called antibiotics) whereas 632: 306:red protected mice from pathogenic 242:In the years between 1876 and 1884 24: 4095:Medical Scientist Training Program 3324:Fluorescence in situ hybridization 699:plates growing colonies of common 353:The Institute for Genomic Research 231:is considered to be the father of 135:, just as the state of the art in 25: 4265: 2888:Antibiotic susceptibility testing 2695:biochemical and immunologic tests 2432: 2273:Molecular Diagnostic PCR Handbook 2160:. McGraw Hill. pp. 336–337. 2158:Microbiology: A human perspective 1354: 1316:Current Protocols in Microbiology 340:which was produced in 1979 using 4227: 4217: 4207: 4197: 4188: 4187: 3292:Oral and maxillofacial pathology 2916:Minimum inhibitory concentration 2608:Manual testing: basic techniques 1964:Rhinehart E; Friedman M (1999). 1514:from the original on 2015-10-28. 1039:Journal of Clinical Microbiology 774:Transmission electron microscopy 365:. A few months later, the first 200:Following on from this, in 1857 4228: 2420: 2410: 2401: 2354: 2345: 2224: 2215: 1988: 1831: 1820:from the original on 2013-05-03 1795:from the original on 2013-04-19 1770:from the original on 2013-04-25 1669:from the original on 2011-07-12 1609:from the original on 2013-04-20 1458: 1449: 1436: 1423: 1382: 1324:10.1002/9780471729259.mca03cs00 1318:. Appendix 3 (1): Appendix 3C. 1199:Brock Biology of Microorganisms 1082:Tan, S. Y.; Berman, E. (2008). 940:of antimicrobial drugs and any 812:selective liquid or solid media 88:studies the characteristics of 61:that cause infectious disease: 4085:Doctor of Osteopathic Medicine 3519:Oral and maxillofacial surgery 2824:Novobiocin susceptibility test 2814:Bacitracin susceptibility test 1967:Infection control in home care 1603:"World Health Statistics 2012" 1303: 1275: 1215: 1158:10.1080/08998280.2005.11928028 1133: 1106: 1075: 1026: 743:Cell culture: Human or animal 355:sequenced the first bacterial 13: 1: 3020: 2707:Amino acid decarboxylase test 2379:10.1016/S0140-6736(01)05321-1 1665:. World Health Organization. 1605:. World Health Organization. 1543:10.1016/S0140-6736(12)61729-2 1020: 879: 751: 4065:Bachelor of Medical Sciences 3832:Neurosurgical anesthesiology 3444: 2819:Optochin susceptibility test 2782:Sulfide indole motility test 2767:Phenylalanine deaminase test 2298:Encyclopedia of Microbiology 2296:Tang YW; Persing DH (2009). 1895:"10 Principles of Diagnosis" 1850:(6): 465–484, quiz 485–486. 1395:Emerging Infectious Diseases 909:infections are treated with 779:Scanning electron microscopy 496:Infections may be caused by 112:or other treatment methods. 7: 2110:Journal of General Virology 2045:Hilleman M (October 2004). 824:to bind specifically to an 790:Fast and relatively simple 10: 4270: 1641:10.1016/j.yapd.2012.04.002 761:compound light microscopes 636: 619:body's own immune response 489: 146: 129:public health microbiology 4183: 4105: 4043: 3804: 3732: 3687: 3596: 3467: 3452: 3332: 3257: 3028: 2928: 2886: 2863:Polymerase chain reaction 2842: 2692: 2607: 2596: 2566: 2525: 2499: 2485: 1856:10.1007/s00105-015-3631-z 1742:10.4269/ajtmh.1994.50.705 1088:Singapore Medical Journal 841:Polymerase chain reaction 836:Polymerase chain reaction 392:Streptococcal pharyngitis 189:developed a method using 27:Branch of medical science 4019:Transplantation medicine 3910:Clinical neurophysiology 3827:Obstetric anesthesiology 3747:Interventional radiology 3507:Digestive system surgery 2853:Analytical profile index 2275:. Springer. p. 58. 2057:(Suppl 2): 14560–14566. 1943:. Elsevier. p. 87. 975:Antimicrobial resistance 770:fluorescence microscopes 645:gastrointestinal disease 623:immunological resistance 324:, a method developed by 250:. This gave rise to the 3890:Intensive care medicine 3864:Mass gathering medicine 3709:Maternal–fetal medicine 3399:Microbiological culture 3029:Principles of pathology 2072:10.1073/pnas.0404758101 1893:Washington, JA (1996). 1389:Gaynes, Robert (2017). 1366:Prescott's Microbiology 1310:Coico, Richard (2006). 1140:Riedel, Stefan (2005). 708:Microbiological culture 639:Diagnostic microbiology 3482:Cardiothoracic surgery 2787:Triple sugar iron test 2122:10.1099/vir.0.039909-0 1706:10.1001/jama.297.8.813 1629:Advances in Pediatrics 1492:10.1542/peds.2009-2648 1407:10.3201/eid2305.161556 952: 934:antibiotic resistances 704: 608:introduced to the cell 562:- Coughing or sneezing 529:gastrointestinal tract 362:Haemophilus influenzae 171: 159: 41:, the large subset of 35: 4133:Personalized medicine 3992:Reproductive medicine 3917:Occupational medicine 3871:Evolutionary medicine 3362:Diagnostic immunology 3187:Programmed cell death 3155:Liquefactive necrosis 2845:point-of-care testing 2526:Cultures by body site 2479:clinical microbiology 2200:10.1093/occmed/kqh106 2187:Occupational Medicine 2008:. In Baron, S (ed.). 1897:. In Baron, S (ed.). 971:antibiotic resistance 950: 694: 627:Feline leukemia virus 591:Nosocomial infections 176:Anton van Leeuwenhoek 165: 156:Anton van Leeuwenhoek 154: 141:research laboratories 137:clinical laboratories 133:clinical microbiology 33: 4254:Medical microbiology 4153:Traditional medicine 4113:Alternative medicine 3980:Addiction psychiatry 3794:Transfusion medicine 3789:Medical microbiology 3704:Gynecologic oncology 3556:Reproductive surgery 3357:Medical microbiology 3352:Transfusion medicine 3309:Immunohistochemistry 3259:Anatomical pathology 3150:Coagulative necrosis 2804:Voges–Proskauer test 2712:Bile solubility test 2567:Cultures by organism 2500:Isolation techniques 2439:Medical Microbiology 2010:Medical Microbiology 1899:Medical Microbiology 1242:10.7759/cureus.32777 1051:10.1128/JCM.01575-10 987:extracellular matrix 895:Bacterial infections 766:Electron microscopes 734:colloidal suspension 429:Human papillomavirus 39:Medical microbiology 4175:History of medicine 4158:Veterinary medicine 3965:Preventive medicine 3817:Adolescent medicine 3659:Infectious diseases 3314:Electron microscopy 3282:Molecular pathology 3160:Gangrenous necrosis 3092:Cellular adaptation 2911:McFarland standards 2901:Disk diffusion test 2896:Beta-lactamase test 2829:Lancefield grouping 2809:X and V factor test 2777:Salt tolerance test 2652:Ziehl–Neelsen stain 2615:Colonial morphology 2063:2004PNAS..10114560H 2006:"42 Multiplication" 2004:Roizman, B (1996). 849:gel electrophoresis 584:Fomite transmission 578:Vector transmission 533:genitourinary tract 267:Hans Christian Gram 182:of his own design. 55:infectious diseases 4123:Molecular oncology 4080:Doctor of Medicine 4070:Master of Medicine 3987:Radiation oncology 3859:Emergency medicine 3812:Addiction medicine 3779:Clinical chemistry 3774:Clinical pathology 3566:Transplant surgery 3524:Orthopedic surgery 3502:Colorectal surgery 3342:Clinical chemistry 3334:Clinical pathology 3319:Immunofluorescence 3287:Forensic pathology 3267:Surgical pathology 3175:Fibrinoid necrosis 2980:Inoculation needle 2321:WHO (April 2014). 953: 923:parasitic diseases 921:are used to treat 757:Culture techniques 705: 351:In 1995 a team at 172: 160: 36: 4241: 4240: 4075:Master of Surgery 4039: 4038: 4024:Tropical medicine 3970:Prison healthcare 3885:Hospital medicine 3849:Disaster medicine 3839:Aviation medicine 3654:Hospital medicine 3561:Surgical oncology 3546:Pediatric surgery 3540: 3487:Endocrine surgery 3412: 3411: 3379:Mass spectrometry 2988: 2987: 2965:Biosafety cabinet 2924: 2923: 2772:Reverse CAMP test 2592: 2591: 2574:Bacterial culture 2307:978-0-12-373944-5 2282:978-1-4020-3404-6 2243:Mackay I (2007). 2167:978-1-55938-814-6 2019:978-0-9631172-1-2 1981:978-0-8342-1143-8 1950:978-1-55938-814-6 1908:978-0-9631172-1-2 1537:(9859): 2163–96. 1375:978-1-260-21188-7 1296:978-1-55581-143-3 1208:978-0-321-73551-5 1045:(10): 3465–3469. 944:the patient has. 897:are treated with 792:biochemical tests 786:Biochemical tests 687:Microbial culture 661:biochemical tests 653:microbial culture 525:respiratory tract 455:Toxoplasma gondii 374:CRIPR-Cas systems 289:Alexander Fleming 256:Koch's postulates 222:food preservation 18:Clinical virology 16:(Redirected from 4261: 4231: 4230: 4221: 4211: 4210: 4201: 4200: 4191: 4190: 3895:Medical genetics 3880:General practice 3757:Nuclear medicine 3632:Gastroenterology 3588:Vascular surgery 3538: 3465: 3464: 3439: 3432: 3425: 3416: 3415: 3299:Gross processing 3165:Caseous necrosis 3015: 3008: 3001: 2992: 2991: 2975:Inoculation loop 2873:Rapid strep test 2605: 2604: 2497: 2496: 2471: 2464: 2457: 2448: 2447: 2427: 2424: 2418: 2414: 2408: 2405: 2399: 2398: 2358: 2352: 2349: 2343: 2342: 2340: 2338: 2329:. Archived from 2318: 2312: 2311: 2293: 2287: 2286: 2268: 2259: 2258: 2240: 2231: 2228: 2222: 2219: 2213: 2212: 2202: 2178: 2172: 2171: 2153: 2144: 2143: 2133: 2101: 2095: 2094: 2084: 2074: 2042: 2036: 2035: 2030:. Archived from 2001: 1995: 1992: 1986: 1985: 1961: 1955: 1954: 1936: 1925: 1924: 1923:on 13 June 2016. 1919:. Archived from 1890: 1884: 1883: 1835: 1829: 1828: 1826: 1825: 1814:"Histoplasmosis" 1810: 1804: 1803: 1801: 1800: 1785: 1779: 1778: 1776: 1775: 1760: 1754: 1753: 1725: 1719: 1718: 1708: 1684: 1678: 1677: 1675: 1674: 1659: 1653: 1652: 1624: 1618: 1617: 1615: 1614: 1599: 1590: 1589: 1587: 1586: 1571: 1565: 1564: 1554: 1522: 1516: 1515: 1471: 1465: 1462: 1456: 1453: 1447: 1440: 1434: 1427: 1421: 1420: 1418: 1386: 1380: 1379: 1361: 1352: 1351: 1307: 1301: 1300: 1279: 1273: 1272: 1262: 1244: 1219: 1213: 1212: 1194: 1188: 1187: 1177: 1137: 1131: 1130: 1110: 1104: 1103: 1079: 1073: 1072: 1062: 1030: 865:quantitative PCR 853:quantitative PCR 845:quantitative PCR 633:Diagnostic tests 566:Fecal–oral route 541:mucous membranes 330:Frederick Sanger 21: 4269: 4268: 4264: 4263: 4262: 4260: 4259: 4258: 4244: 4243: 4242: 4237: 4179: 4168:Chief physician 4101: 4046: 4035: 4029:Travel medicine 4014:Sports medicine 3997:Sexual medicine 3937:Palliative care 3932:Pain management 3876:Family medicine 3854:Diving medicine 3800: 3728: 3690: 3683: 3599: 3592: 3551:Plastic surgery 3497:General surgery 3477:Cardiac surgery 3458: 3456: 3448: 3443: 3413: 3408: 3367:Immunopathology 3347:Hematopathology 3328: 3253: 3024: 3019: 2989: 2984: 2920: 2882: 2838: 2747:Methyl red test 2694: 2693:Manual testing: 2688: 2647:India ink stain 2637:Acid-fast stain 2600: 2588: 2562: 2538:Genital culture 2521: 2517:Selective media 2489: 2481: 2475: 2444: 2435: 2430: 2425: 2421: 2415: 2411: 2406: 2402: 2373:(9276): 135–8. 2359: 2355: 2350: 2346: 2336: 2334: 2333:on May 15, 2015 2319: 2315: 2308: 2294: 2290: 2283: 2269: 2262: 2255: 2241: 2234: 2229: 2225: 2220: 2216: 2179: 2175: 2168: 2154: 2147: 2102: 2098: 2043: 2039: 2034:on 11 May 2018. 2020: 2002: 1998: 1993: 1989: 1982: 1962: 1958: 1951: 1937: 1928: 1909: 1891: 1887: 1836: 1832: 1823: 1821: 1812: 1811: 1807: 1798: 1796: 1787: 1786: 1782: 1773: 1771: 1764:"Toxoplasmosis" 1762: 1761: 1757: 1726: 1722: 1685: 1681: 1672: 1670: 1661: 1660: 1656: 1625: 1621: 1612: 1610: 1601: 1600: 1593: 1584: 1582: 1575:"Typhoid Fever" 1573: 1572: 1568: 1523: 1519: 1472: 1468: 1463: 1459: 1454: 1450: 1441: 1437: 1428: 1424: 1387: 1383: 1376: 1362: 1355: 1312:"Gram Staining" 1308: 1304: 1297: 1280: 1276: 1220: 1216: 1209: 1195: 1191: 1138: 1134: 1111: 1107: 1094:(11): 854–855. 1080: 1076: 1031: 1027: 1023: 882: 838: 788: 754: 689: 641: 635: 560:Droplet contact 494: 488: 448:Giardia lamblia 383: 342:recombinant DNA 149: 28: 23: 22: 15: 12: 11: 5: 4267: 4257: 4256: 4239: 4238: 4236: 4235: 4225: 4215: 4205: 4195: 4184: 4181: 4180: 4178: 4177: 4172: 4171: 4170: 4160: 4155: 4150: 4145: 4140: 4135: 4130: 4125: 4120: 4115: 4109: 4107: 4106:Related topics 4103: 4102: 4100: 4099: 4098: 4097: 4087: 4082: 4077: 4072: 4067: 4062: 4057: 4055:Medical school 4051: 4049: 4041: 4040: 4037: 4036: 4034: 4033: 4032: 4031: 4021: 4016: 4011: 4009:Sleep medicine 4006: 4005: 4004: 3994: 3989: 3984: 3983: 3982: 3972: 3967: 3962: 3956: 3951: 3950: 3949: 3939: 3934: 3929: 3924: 3919: 3914: 3913: 3912: 3902: 3897: 3892: 3887: 3882: 3873: 3868: 3867: 3866: 3856: 3851: 3846: 3841: 3836: 3835: 3834: 3829: 3822:Anesthesiology 3819: 3814: 3808: 3806: 3802: 3801: 3799: 3798: 3797: 3796: 3791: 3786: 3781: 3776: 3771: 3761: 3760: 3759: 3754: 3752:Neuroradiology 3749: 3738: 3736: 3730: 3729: 3727: 3726: 3721: 3716: 3711: 3706: 3701: 3695: 3693: 3689:Obstetrics and 3685: 3684: 3682: 3681: 3676: 3671: 3666: 3661: 3656: 3651: 3646: 3641: 3640: 3639: 3629: 3624: 3619: 3614: 3604: 3602: 3594: 3593: 3591: 3590: 3585: 3584: 3583: 3573: 3571:Trauma surgery 3568: 3563: 3558: 3553: 3548: 3543: 3542: 3541: 3534:Otolaryngology 3531: 3526: 3521: 3516: 3511: 3510: 3509: 3504: 3494: 3489: 3484: 3479: 3473: 3471: 3462: 3460:subspecialties 3450: 3449: 3442: 3441: 3434: 3427: 3419: 3410: 3409: 3407: 3406: 3401: 3396: 3391: 3389:Flow cytometry 3386: 3384:Chromatography 3381: 3376: 3370: 3369: 3364: 3359: 3354: 3349: 3344: 3338: 3336: 3330: 3329: 3327: 3326: 3321: 3316: 3311: 3306: 3304:Histopathology 3301: 3295: 3294: 3289: 3284: 3279: 3274: 3269: 3263: 3261: 3255: 3254: 3252: 3251: 3246: 3245: 3244: 3239: 3230: 3218: 3212: 3211: 3206: 3201: 3196: 3195: 3194: 3184: 3183: 3182: 3177: 3172: 3167: 3162: 3157: 3152: 3142: 3140: 3134: 3133: 3132: 3131: 3126: 3116: 3111: 3106: 3101: 3096: 3094: 3088: 3087: 3082: 3077: 3072: 3071: 3070: 3060: 3059: 3058: 3053: 3048: 3043: 3032: 3030: 3026: 3025: 3018: 3017: 3010: 3003: 2995: 2986: 2985: 2983: 2982: 2977: 2972: 2967: 2962: 2957: 2956: 2955: 2945: 2944: 2943: 2932: 2930: 2926: 2925: 2922: 2921: 2919: 2918: 2913: 2908: 2903: 2898: 2892: 2890: 2884: 2883: 2881: 2880: 2875: 2870: 2865: 2860: 2855: 2849: 2847: 2843:Automated and 2840: 2839: 2837: 2836: 2831: 2826: 2821: 2816: 2811: 2806: 2801: 2800: 2799: 2789: 2784: 2779: 2774: 2769: 2764: 2759: 2754: 2749: 2744: 2739: 2734: 2729: 2727:Coagulase test 2724: 2719: 2714: 2709: 2704: 2698: 2696: 2690: 2689: 2687: 2686: 2685: 2684: 2679: 2674: 2669: 2661: 2656: 2655: 2654: 2649: 2644: 2639: 2634: 2624: 2623: 2622: 2611: 2609: 2602: 2598:Identification 2594: 2593: 2590: 2589: 2587: 2586: 2581: 2579:Fungal culture 2576: 2570: 2568: 2564: 2563: 2561: 2560: 2555: 2550: 2548:Throat culture 2545: 2543:Sputum culture 2540: 2535: 2529: 2527: 2523: 2522: 2520: 2519: 2514: 2509: 2503: 2501: 2494: 2483: 2482: 2477:Techniques in 2474: 2473: 2466: 2459: 2451: 2442: 2441: 2434: 2433:External links 2431: 2429: 2428: 2419: 2409: 2400: 2353: 2344: 2313: 2306: 2288: 2281: 2260: 2253: 2232: 2223: 2214: 2173: 2166: 2145: 2116:(4): 900–905. 2096: 2037: 2018: 1996: 1987: 1980: 1956: 1949: 1926: 1907: 1885: 1830: 1805: 1780: 1755: 1720: 1679: 1654: 1619: 1591: 1566: 1517: 1486:(3): 557–564. 1466: 1457: 1448: 1435: 1422: 1401:(5): 849–853. 1381: 1374: 1353: 1302: 1295: 1274: 1235:(12): e32777. 1214: 1207: 1189: 1132: 1105: 1074: 1024: 1022: 1019: 999:Bacteriophages 942:drug allergies 919:antiparasitics 899:antibacterials 881: 878: 837: 834: 787: 784: 753: 750: 749: 748: 741: 730: 688: 685: 637:Main article: 634: 631: 595: 594: 587: 581: 575: 569: 563: 557: 554: 552:sexual contact 487: 484: 483: 482: 477: 475:Histoplasmosis 472: 459: 458: 451: 444: 433: 432: 426: 421: 410: 409: 404: 399: 394: 382: 379: 326:Walter Gilbert 322:DNA sequencing 300:Gerhard Domagk 218:pasteurization 148: 145: 86:microbiologist 59:microorganisms 26: 9: 6: 4: 3: 2: 4266: 4255: 4252: 4251: 4249: 4234: 4226: 4224: 4220: 4216: 4214: 4206: 4204: 4196: 4194: 4186: 4185: 4182: 4176: 4173: 4169: 4166: 4165: 4164: 4161: 4159: 4156: 4154: 4151: 4149: 4146: 4144: 4141: 4139: 4138:Public health 4136: 4134: 4131: 4129: 4126: 4124: 4121: 4119: 4118:Allied health 4116: 4114: 4111: 4110: 4108: 4104: 4096: 4093: 4092: 4091: 4088: 4086: 4083: 4081: 4078: 4076: 4073: 4071: 4068: 4066: 4063: 4061: 4058: 4056: 4053: 4052: 4050: 4048: 4042: 4030: 4027: 4026: 4025: 4022: 4020: 4017: 4015: 4012: 4010: 4007: 4003: 4000: 3999: 3998: 3995: 3993: 3990: 3988: 3985: 3981: 3978: 3977: 3976: 3973: 3971: 3968: 3966: 3963: 3960: 3957: 3955: 3952: 3948: 3945: 3944: 3943: 3940: 3938: 3935: 3933: 3930: 3928: 3927:Oral medicine 3925: 3923: 3922:Ophthalmology 3920: 3918: 3915: 3911: 3908: 3907: 3906: 3903: 3901: 3898: 3896: 3893: 3891: 3888: 3886: 3883: 3881: 3877: 3874: 3872: 3869: 3865: 3862: 3861: 3860: 3857: 3855: 3852: 3850: 3847: 3845: 3842: 3840: 3837: 3833: 3830: 3828: 3825: 3824: 3823: 3820: 3818: 3815: 3813: 3810: 3809: 3807: 3803: 3795: 3792: 3790: 3787: 3785: 3784:Cytopathology 3782: 3780: 3777: 3775: 3772: 3770: 3767: 3766: 3765: 3762: 3758: 3755: 3753: 3750: 3748: 3745: 3744: 3743: 3740: 3739: 3737: 3735: 3731: 3725: 3724:Urogynecology 3722: 3720: 3717: 3715: 3712: 3710: 3707: 3705: 3702: 3700: 3697: 3696: 3694: 3692: 3686: 3680: 3677: 3675: 3672: 3670: 3667: 3665: 3662: 3660: 3657: 3655: 3652: 3650: 3647: 3645: 3642: 3638: 3635: 3634: 3633: 3630: 3628: 3627:Endocrinology 3625: 3623: 3620: 3618: 3615: 3613: 3609: 3606: 3605: 3603: 3601: 3595: 3589: 3586: 3582: 3579: 3578: 3577: 3574: 3572: 3569: 3567: 3564: 3562: 3559: 3557: 3554: 3552: 3549: 3547: 3544: 3537: 3536: 3535: 3532: 3530: 3527: 3525: 3522: 3520: 3517: 3515: 3512: 3508: 3505: 3503: 3500: 3499: 3498: 3495: 3493: 3490: 3488: 3485: 3483: 3480: 3478: 3475: 3474: 3472: 3470: 3466: 3463: 3461: 3455: 3451: 3447: 3440: 3435: 3433: 3428: 3426: 3421: 3420: 3417: 3405: 3402: 3400: 3397: 3395: 3392: 3390: 3387: 3385: 3382: 3380: 3377: 3375: 3372: 3371: 3368: 3365: 3363: 3360: 3358: 3355: 3353: 3350: 3348: 3345: 3343: 3340: 3339: 3337: 3335: 3331: 3325: 3322: 3320: 3317: 3315: 3312: 3310: 3307: 3305: 3302: 3300: 3297: 3296: 3293: 3290: 3288: 3285: 3283: 3280: 3278: 3275: 3273: 3272:Cytopathology 3270: 3268: 3265: 3264: 3262: 3260: 3256: 3250: 3247: 3243: 3240: 3238: 3234: 3231: 3229: 3226: 3225: 3224: 3223: 3219: 3217: 3216:Accumulations 3214: 3213: 3210: 3207: 3205: 3202: 3200: 3197: 3193: 3190: 3189: 3188: 3185: 3181: 3178: 3176: 3173: 3171: 3168: 3166: 3163: 3161: 3158: 3156: 3153: 3151: 3148: 3147: 3146: 3143: 3141: 3139: 3136: 3135: 3130: 3127: 3125: 3122: 3121: 3120: 3117: 3115: 3112: 3110: 3107: 3105: 3102: 3100: 3097: 3095: 3093: 3090: 3089: 3086: 3085:Wound healing 3083: 3081: 3078: 3076: 3073: 3069: 3066: 3065: 3064: 3061: 3057: 3054: 3052: 3049: 3047: 3044: 3042: 3039: 3038: 3037: 3034: 3033: 3031: 3027: 3023: 3016: 3011: 3009: 3004: 3002: 2997: 2996: 2993: 2981: 2978: 2976: 2973: 2971: 2968: 2966: 2963: 2961: 2958: 2954: 2951: 2950: 2949: 2948:Anaerobic jar 2946: 2942: 2941:Growth medium 2939: 2938: 2937: 2934: 2933: 2931: 2927: 2917: 2914: 2912: 2909: 2907: 2904: 2902: 2899: 2897: 2894: 2893: 2891: 2889: 2885: 2879: 2878:Monospot test 2876: 2874: 2871: 2869: 2866: 2864: 2861: 2859: 2856: 2854: 2851: 2850: 2848: 2846: 2841: 2835: 2832: 2830: 2827: 2825: 2822: 2820: 2817: 2815: 2812: 2810: 2807: 2805: 2802: 2798: 2795: 2794: 2793: 2790: 2788: 2785: 2783: 2780: 2778: 2775: 2773: 2770: 2768: 2765: 2763: 2760: 2758: 2755: 2753: 2750: 2748: 2745: 2743: 2740: 2738: 2735: 2733: 2730: 2728: 2725: 2723: 2720: 2718: 2715: 2713: 2710: 2708: 2705: 2703: 2700: 2699: 2697: 2691: 2683: 2680: 2678: 2675: 2673: 2670: 2668: 2665: 2664: 2662: 2660: 2657: 2653: 2650: 2648: 2645: 2643: 2640: 2638: 2635: 2633: 2630: 2629: 2628: 2625: 2621: 2618: 2617: 2616: 2613: 2612: 2610: 2606: 2603: 2599: 2595: 2585: 2584:Viral culture 2582: 2580: 2577: 2575: 2572: 2571: 2569: 2565: 2559: 2558:Wound culture 2556: 2554: 2553:Urine culture 2551: 2549: 2546: 2544: 2541: 2539: 2536: 2534: 2533:Blood culture 2531: 2530: 2528: 2524: 2518: 2515: 2513: 2510: 2508: 2505: 2504: 2502: 2498: 2495: 2493: 2488: 2484: 2480: 2472: 2467: 2465: 2460: 2458: 2453: 2452: 2449: 2445: 2440: 2437: 2436: 2423: 2413: 2404: 2396: 2392: 2388: 2384: 2380: 2376: 2372: 2368: 2364: 2357: 2348: 2332: 2328: 2324: 2317: 2309: 2303: 2299: 2292: 2284: 2278: 2274: 2267: 2265: 2256: 2254:9781904455189 2250: 2246: 2239: 2237: 2227: 2218: 2210: 2206: 2201: 2196: 2192: 2188: 2184: 2177: 2169: 2163: 2159: 2152: 2150: 2141: 2137: 2132: 2127: 2123: 2119: 2115: 2111: 2107: 2100: 2092: 2088: 2083: 2078: 2073: 2068: 2064: 2060: 2056: 2052: 2048: 2041: 2033: 2029: 2025: 2021: 2015: 2011: 2007: 2000: 1991: 1983: 1977: 1973: 1969: 1968: 1960: 1952: 1946: 1942: 1935: 1933: 1931: 1922: 1918: 1914: 1910: 1904: 1900: 1896: 1889: 1881: 1877: 1873: 1869: 1865: 1861: 1857: 1853: 1849: 1845: 1841: 1834: 1819: 1815: 1809: 1794: 1790: 1789:"Candidiasis" 1784: 1769: 1765: 1759: 1751: 1747: 1743: 1739: 1736:(6): 705–13. 1735: 1731: 1724: 1716: 1712: 1707: 1702: 1698: 1694: 1690: 1683: 1668: 1664: 1663:"Hepatitis C" 1658: 1650: 1646: 1642: 1638: 1634: 1630: 1623: 1608: 1604: 1598: 1596: 1581:on 2011-11-02 1580: 1576: 1570: 1562: 1558: 1553: 1548: 1544: 1540: 1536: 1532: 1528: 1521: 1513: 1509: 1505: 1501: 1497: 1493: 1489: 1485: 1481: 1477: 1470: 1461: 1452: 1445: 1439: 1433:74:5463-5467. 1432: 1426: 1417: 1412: 1408: 1404: 1400: 1396: 1392: 1385: 1377: 1371: 1367: 1360: 1358: 1349: 1345: 1341: 1337: 1333: 1329: 1325: 1321: 1317: 1313: 1306: 1298: 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Index

Clinical virology

microbiology
applied
medicine
infectious diseases
microorganisms
bacteria
fungi
parasites
viruses
prion
microbiologist
pathogens
physicians
virulent
epidemics
pathology
antibiotics
Epidemiology
health
disease
clinical laboratories
research laboratories

Anton van Leeuwenhoek

Robert Koch
Anton van Leeuwenhoek
microscope

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