316:
182:
25:
117:
132:
498:
Since NO maintains low tone and high compliance of the small arteries at rest, a reduction of age-dependent small artery compliance is a marker for endothelial dysfunction that is associated with both functional and structural changes in the microcirculation. Small artery compliance or stiffness can
569:. Calcium channel blockers and selective beta 1 antagonists may also improve endothelial dysfunction. Life style modifications such as smoking cessation have also been shown to improve endothelial function and lower the risk of major cardiovascular events.
386:
Nitric oxide (NO) suppresses platelet aggregation, inflammation, oxidative stress, vascular smooth muscle cell migration and proliferation, and leukocyte adhesion. A feature of endothelial dysfunction is the inability of
1312:
419:(BH4) supplementation has shown beneficial results for the treatment of endothelial dysfunction in animal experiments and clinical trials, although the tendency of BH4 to become oxidized to BH2 remains a problem.
1361:
Yuyun MF, Ng LL, Ng GA (2018). "Endothelial dysfunction, endothelial nitric oxide bioavailability, tetrahydrobiopterin, and 5-methyltetrahydrofolate in cardiovascular disease. Where are we with therapy?".
406:
from the endothelium like NO. Endothelial dysfunction is commonly associated with decreased NO bioavailability, which is due to impaired NO production by the endothelium or inactivation of NO by reactive
1848:
Unverdorben, Martin; Vallbracht, Christian; Cremers, Bodo; Heuer, Hubertus; Hengstenberg, Christian; Maikowski, Christian; Werner, Gerald S.; Antoni, Diethmar; Kleber, Franz X. (2009-06-16).
696:
Sitia, S.; Tomasoni, L.; Atzeni, F.; Ambrosio, G.; Cordiano, C.; Catapano, A.; Tramontana, S.; Perticone, F.; Naccarato, P. (2010). "From endothelial dysfunction to atherosclerosis".
1979:
Briasoulis A, Tousoulis D, Androulakis ES, Papageorgiou N, Latsios G, Stefanadis C (Apr 2012). "Endothelial dysfunction and atherosclerosis: focus on novel therapeutic approaches".
458:(FMD) as measured by Brachial Artery Ultrasound Imaging (BAUI). Current measurements of endothelial function via FMD vary due to technical and physiological factors. Furthermore, a
366:
are well known to contribute to endothelial dysfunction, and lowering blood pressure and LDL has been shown to improve endothelial function, particularly when lowered with
1677:
Gilani M, Kaiser DR, Bratteli CW, Alinder C, Rajala Bank AJ, Cohn JN (2007). "Role of nitric oxide deficiency and its detection as a risk factor in pre-hypertension".
302:, tightly controlled vascular permeability, and anti-thrombotic and anti-inflammatory properties. This balance ensures the smooth functioning of the vascular system.
462:
between percent flow mediated dilation and baseline artery size is recognised as a fundamental scaling problem, leading to biased estimates of endothelial function.
518:, but further investigation showed that they often impair endothelial function in humans and worsen conditions. One drug used to inhibit restenosis is
35:
731:
Flammer AJ, Anderson T, Celermajer DS, Creager MA, Deanfield J, Ganz P, Hamburg NM, LĂĽscher TF, Shechter M, Taddei S, Vita JA, Lerman A (Aug 2012).
1940:"Cardiovascular risk reduction by reversing endothelial dysfunction: ARBs, ACE inhibitors, or both? Expectations from the ONTARGET Trial Programme"
378:. Steadily laminar flow with high shear stress in blood vessels protects against atherosclerosis, whereas disturbed flow promotes atherosclerosis.
150:
491:
when compared against the gold standard, acetylcholine angiogram. This results suggests that this peripheral test reflects the physiology of the
849:
Maruhashi, T; Kihara, Y; Higashi, Y (2018). "Assessment of endothelium-independent vasodilation: From methodology to clinical perspectives".
1714:"Association of small artery elasticity with incident cardiovascular disease in older adults: the multiethnic study of atherosclerosis"
96:
68:
1450:
Thijssen DH, Black MA, Pyke KE, Padilla J, Atkinson G, Harris RA, Parker B, Widlansky ME, Tschakovsky ME, Green DJ (Jan 2011).
75:
1276:
1153:
897:"Functionally defective high-density lipoprotein and paraoxonase: a couple for endothelial dysfunction in atherosclerosis"
1149:"Mechanisms of Oxidized LDL-Mediated Endothelial Dysfunction and Its Consequences for the Development of Atherosclerosis"
604:
566:
82:
1638:"Noninvasive identification of patients with early coronary atherosclerosis by assessment of digital reactive hyperemia"
649:
948:"Dysfunctional Vascular Endothelium as a Driver of Atherosclerosis: Emerging Insights Into Pathogenesis and Treatment"
1850:"Paclitaxel-coated balloon catheter versus paclitaxel-coated stent for the treatment of coronary in-stent restenosis"
168:
64:
54:
499:
be assessed simply and at rest and can be distinguished from large artery stiffness by use of pulsewave analysis.
1712:
Duprez DA, Jacobs DR, Lutsey PL, Bluemke FA, Brumback LC, Polak JF, Peralta CA, Greenland P, Kronmal RA (2011).
1899:"Endothelial dysfunction in COVID-19: an overview of evidence, biomarkers, mechanisms and potential therapies"
1401:"Flow mediated dilation of the brachial artery: an investigation of methods requiring further standardization"
340:
451:
287:. The result of this endothelial dysregulation is a cascade of adverse effects, including vasoconstriction,
476:
2068:
1399:
Peretz, Alon; Daniel F Leotta; Jeffrey H Sullivan; Carol A Trenga; Fiona N Sands; Mary R Aulet (2007).
534:
COVID-19 can present with an acute lung injury manifestation that arises from endothelial dysfunction.
268:
1761:
Cohn JN, Duprez DA, Finkelstein SM (2009). "Comprehensive noninvasive arterial vascular evaluation".
315:
89:
43:
327:
and may predate vascular pathology. Endothelial dysfunction may also lead to increased adherence of
2016:"Smoking and cardiovascular disease: mechanisms of endothelial dysfunction and early atherogenesis"
439:
responses to vasoactive agents may be used to test for endothelial function, and venous occlusion
488:
371:
336:
288:
146:
50:
39:
583:
455:
209:
1452:"Assessment of flow-mediated dilation in humans: a methodological and physiological guideline"
594:
465:
459:
412:
264:
240:
547:
492:
480:
428:
8:
785:"Endothelium Infection and Dysregulation by SARS-CoV-2: Evidence and Caveats in COVID-19"
469:
416:
510:
implantation has been correlated with impaired endothelial function in several studies.
1956:
1939:
1923:
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1800:
1738:
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979:
928:
866:
824:
806:
762:
713:
678:
1257:
Konukoglu, Dildar; Uzun, Hafize (2017). "Endothelial
Dysfunction and Hypertension".
1087:
1032:
2027:
1988:
1951:
1918:
1910:
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1324:
1264:
1229:
1213:
1172:
1162:
1119:
1110:
1059:
1010:
999:"Pathophysiology, diagnosis and prognostic implications of endothelial dysfunction"
969:
959:
918:
908:
878:
858:
814:
796:
783:
Bernard, Isabelle; Limonta, Daniel; Mahal, Lara K.; Hobman, Tom C. (January 2021).
752:
744:
705:
668:
658:
256:
236:
217:
190:
1552:"Assessment of peripheral vascular endothelial function in the ambulatory setting"
1518:
1263:. Advances in Experimental Medicine and Biology. Vol. 956. pp. 511–540.
1106:"Oxidized LDL and NO synthesis--Biomarkers of endothelial dysfunction and ageing"
862:
709:
578:
444:
440:
436:
324:
292:
1467:
2032:
2015:
1992:
1914:
1690:
1654:
1637:
1636:
Bonetti PO, Pumper GM, Higano ST, Holmes DR Jr, Kuvin JT, Lerman A (Dec 2004).
1328:
1063:
645:"Targeting Early Atherosclerosis: A Focus on Oxidative Stress and Inflammation"
562:
484:
399:
1377:
1124:
1105:
1015:
998:
964:
733:"The assessment of endothelial function: from research into clinical practice"
514:
eluting stents were previously used because they showed low rates of in-stent
2062:
2041:
1875:
1816:
1568:
1551:
1336:
1286:
1225:
1167:
1071:
810:
367:
280:
213:
1258:
1047:
487:'s EndoPAT. It has shown an 80% sensitivity and 86% specificity to diagnose
479:-approved device for measuring endothelial function that works by measuring
2049:
2000:
1965:
1883:
1834:
1782:
1747:
1698:
1663:
1622:
1577:
1536:
1485:
1436:
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1385:
1344:
1294:
1243:
1186:
1133:
1079:
1024:
983:
932:
870:
828:
766:
717:
682:
663:
621:
599:
588:
543:
403:
363:
359:
299:
248:
221:
202:
201:. The main cause of endothelial dysfunction is impaired bioavailability of
1978:
1217:
913:
1801:"Recent advances to accelerate re-endothelialization for vascular stents"
1729:
1268:
558:
447:
are used to assess endothelial function of peripheral vessels in humans.
432:
229:
198:
181:
468:
is a marker of endothelial dysfunction, and is consistently elevated in
343:
is a hallmark feature of atherosclerosis, by promoting the formation of
609:
523:
515:
392:
351:
332:
284:
244:
225:
53:
if you can. Unsourced or poorly sourced material may be challenged and
1774:
801:
251:. This pathological state is often associated with elevated levels of
519:
511:
396:
344:
252:
1550:
Kuvin JT, Mammen A, Mooney P, Alsheikh-Ali AA, Karas RH (Feb 2007).
295:. These changes contribute to the progression of vascular diseases.
1593:"Assessing endothelial vasodilator function with the Endo-PAT 2000"
614:
388:
355:
348:
328:
276:
1847:
1604:
551:
260:
1313:"Hypertension and endothelial dysfunction: therapeutic approach"
1048:"Endothelial dysfunction in the pathogenesis of atherosclerosis"
730:
395:
to dilate fully in response to an appropriate stimulus, such as
319:
Stages of endothelial dysfunction in atherosclerosis of arteries
1635:
408:
375:
323:
Endothelial dysfunction may be involved in the development of
1799:
Bedair, T. M; Elnaggar, M. A; Joung, Y. K; Han, D. K (2017).
1549:
1311:
Ghiadoni, Lorenzo; Taddei, Stefano; Virdis, Agostino (2012).
555:
507:
185:
Comparison of healthy vs. dysfunctional vascular endothelium
16:
Impaired function of the inner lining of blood/lymph vessels
1676:
1501:"Endothelial function in patients with atrial fibrillation"
997:
MĂĽnzel T, Sinning C, Post F, Warnholtz A, Schulz E (2008).
695:
642:
291:, thrombosis, hyperinflammation, and a disrupted antiviral
1306:
1304:
996:
1711:
782:
1897:
Xu, Suo-wen; Ilyas, Iqra; Weng, Jian-ping (April 2023).
1449:
1301:
1798:
1498:
1260:
Hypertension: From basic research to clinical practice
848:
1937:
1760:
529:
502:
1310:
454:
method to measure endothelial dysfunction is %
1200:Le Master, Elizabeth; Levitan, Irena (2019-01-22).
1103:
141:
may be too technical for most readers to understand
2020:Arteriosclerosis, Thrombosis, and Vascular Biology
550:may improve endothelial function in people taking
1590:
212:, the endothelium is responsible for maintaining
2060:
1199:
2013:
1591:Axtell AL, Gomari FA, Cooke JP (October 2010).
1499:Khan AA, Thomas GN, Lip G, Shantsila A (2020).
1356:
1354:
1099:
1097:
894:
643:Marchio P, Guerra-Ojeda S, Mauricio MD (2019).
890:
888:
638:
636:
235:Dysfunctional endothelium is characterized by
220:by releasing mediators, such as nitric oxide,
49:Please review the contents of the article and
1256:
945:
298:In a healthy state, the endothelium exhibits
1931:
1584:
1492:
1351:
1140:
1094:
946:Botts SR, Fish JE, Howe KL (December 2021).
1896:
1146:
990:
885:
633:
2014:Messner, Barbara; Bernhard, David (2014).
1052:Clinical and Applied Thrombosis/Hemostasis
2031:
1955:
1938:Ruilope LM, RedĂłn J, Schmieder R (2007).
1922:
1865:
1824:
1737:
1653:
1612:
1567:
1526:
1475:
1426:
1416:
1360:
1233:
1176:
1166:
1123:
1014:
973:
963:
939:
922:
912:
818:
800:
756:
672:
662:
650:Oxidative Medicine and Cellular Longevity
169:Learn how and when to remove this message
153:, without removing the technical details.
1202:"Endothelial stiffening in dyslipidemia"
422:
314:
197:is a systemic pathological state of the
180:
1104:Gradinaru D, Borsa C, Prada GI (2015).
1045:
358:instability and ultimately to rupture.
335:, as well as promoting infiltration of
2061:
1794:
1792:
354:, and platelet activation, leading to
151:make it understandable to non-experts
1154:Frontiers in Cardiovascular Medicine
1111:Mechanisms of Ageing and Development
844:
842:
840:
838:
778:
776:
125:
18:
1944:Vascular Health and Risk Management
1789:
605:Endothelium-derived relaxing factor
567:angiotensin II receptor antagonists
13:
895:Eren E, Yilmaz N, Aydin O (2013).
554:(HMGCoA-reductase inhibitor), and
530:COVID-19 complication in the lungs
503:Endothelial dysfunction and stents
310:
14:
2080:
1981:Recent Pat Cardiovasc Drug Discov
1867:10.1161/circulationaha.108.839282
1597:Journal of Visualized Experiments
835:
773:
749:10.1161/circulationaha.112.093245
537:
130:
115:
23:
2007:
1972:
1890:
1841:
1754:
1705:
1670:
1629:
1543:
1456:Am J Physiol Heart Circ Physiol
1443:
1392:
1250:
1193:
381:
1147:Jiang M, Zhou Y, Ge J (2022).
1039:
724:
689:
51:add the appropriate references
1:
1805:Journal of Tissue Engineering
1519:10.1080/07853890.2019.1711158
1317:Current Vascular Pharmacology
627:
402:, that stimulates release of
1405:BMC Cardiovascular Disorders
863:10.1097/HJH.0000000000001750
710:10.1016/j.autrev.2010.07.016
411:species. As a co-factor for
7:
1468:10.1152/ajpheart.00471.2010
572:
561:system inhibitors, such as
305:
269:fibrin degradation products
228:, and by controlling local
208:In addition to acting as a
36:reliable medical references
10:
2085:
2033:10.1161/ATVBAHA.113.300156
1993:10.2174/157489012799362386
1915:10.1038/s41401-022-00998-0
1903:Acta Pharmacologica Sinica
1691:10.1016/j.jash.2006.11.002
1655:10.1016/j.jacc.2004.08.062
1329:10.2174/157016112798829823
1064:10.1177/107602960100700404
339:(LDL) in the vessel wall.
1378:10.1016/j.mvr.2018.03.012
1125:10.1016/j.mad.2015.03.003
1016:10.1080/07853890701854702
965:10.3389/fphar.2021.787541
952:Frontiers in Pharmacology
65:"Endothelial dysfunction"
42:or relies too heavily on
1817:10.1177/2041731417731546
1569:10.1177/1358863x06076227
1168:10.3389/fcvm.2022.925923
372:calcium channel blockers
851:Journal of Hypertension
489:coronary artery disease
337:low-density lipoprotein
195:endothelial dysfunction
1418:10.1186/1471-2261-7-11
1365:Microvascular Research
584:Endothelial activation
456:Flow-Mediated Dilation
320:
210:semipermeable membrane
186:
1218:10.18632/aging.101778
595:nitric oxide synthase
466:von Willebrand factor
423:Testing and diagnosis
413:nitric oxide synthase
318:
265:von Willebrand factor
241:vascular permeability
184:
1811:: 2041731417731546.
1269:10.1007/5584_2016_90
1046:Poredos, P. (2001).
698:Autoimmunity Reviews
664:10.1155/2019/8563845
548:hypercholesterolemia
460:negative correlation
429:coronary circulation
914:10.1155/2013/792090
470:atrial fibrillation
417:tetrahydrobiopterin
356:atheromatous plaque
283:(IL-6), and plasma
1730:10.1093/aje/kwr120
1506:Annals of Medicine
1003:Annals of Medicine
481:Reactive Hyperemia
321:
273:C-reactive protein
187:
2069:Vascular diseases
1860:(23): 2986–2994.
1775:10.2217/fca.09.44
1763:Future Cardiology
1642:J Am Coll Cardiol
1278:978-3-319-44250-1
802:10.3390/v13010029
191:vascular diseases
179:
178:
171:
124:
123:
100:
2076:
2054:
2053:
2035:
2011:
2005:
2004:
1976:
1970:
1969:
1959:
1935:
1929:
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1926:
1894:
1888:
1887:
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1828:
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1667:
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1489:
1479:
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1440:
1430:
1420:
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1389:
1358:
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1298:
1254:
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1247:
1237:
1197:
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1180:
1170:
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1137:
1127:
1101:
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1018:
994:
988:
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882:
857:(7): 1460–1467.
846:
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804:
780:
771:
770:
760:
728:
722:
721:
693:
687:
686:
676:
666:
640:
475:A non-invasive,
289:vascular leakage
257:prothrombin time
237:vasoconstriction
218:oxidative stress
174:
167:
163:
160:
154:
134:
133:
126:
119:
118:
110:
107:
101:
99:
58:
27:
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1932:
1895:
1891:
1846:
1842:
1797:
1790:
1759:
1755:
1710:
1706:
1675:
1671:
1648:(11): 2137–41.
1634:
1630:
1589:
1585:
1548:
1544:
1497:
1493:
1448:
1444:
1397:
1393:
1359:
1352:
1309:
1302:
1279:
1255:
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1198:
1194:
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1102:
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1040:
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991:
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940:
893:
886:
847:
836:
781:
774:
729:
725:
704:(12): 830–834.
694:
690:
641:
634:
630:
579:Atherosclerosis
575:
540:
532:
505:
483:Index (RHI) is
445:ultrasonography
441:plethysmography
437:coronary artery
425:
384:
325:atherosclerosis
313:
311:Atherosclerosis
308:
293:immune response
216:and regulating
175:
164:
158:
155:
147:help improve it
144:
135:
131:
120:
116:
111:
105:
102:
59:
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44:primary sources
28:
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5:
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2072:
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2055:
2026:(3): 509–515.
2006:
1971:
1930:
1909:(4): 695–709.
1889:
1840:
1788:
1753:
1718:Am J Epidemiol
1704:
1669:
1628:
1583:
1542:
1491:
1442:
1391:
1350:
1300:
1277:
1249:
1212:(2): 299–300.
1192:
1139:
1093:
1058:(4): 276–280.
1038:
989:
938:
884:
834:
772:
723:
688:
631:
629:
626:
625:
624:
618:
612:
607:
602:
597:
591:
586:
581:
574:
571:
563:ACE inhibitors
539:
538:Risk reduction
536:
531:
528:
504:
501:
485:Itamar Medical
424:
421:
400:nitroglycerine
383:
380:
368:ACE inhibitors
312:
309:
307:
304:
232:-II activity.
177:
176:
138:
136:
129:
122:
121:
114:
112:
31:
29:
22:
15:
9:
6:
4:
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2067:
2066:
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2047:
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2010:
2002:
1998:
1994:
1990:
1986:
1982:
1975:
1967:
1963:
1958:
1953:
1949:
1945:
1941:
1934:
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1920:
1916:
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1904:
1900:
1893:
1885:
1881:
1877:
1873:
1868:
1863:
1859:
1855:
1851:
1844:
1836:
1832:
1827:
1822:
1818:
1814:
1810:
1806:
1802:
1795:
1793:
1784:
1780:
1776:
1772:
1768:
1764:
1757:
1749:
1745:
1740:
1735:
1731:
1727:
1724:(5): 528–36.
1723:
1719:
1715:
1708:
1700:
1696:
1692:
1688:
1684:
1680:
1673:
1665:
1661:
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1647:
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1632:
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1620:
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1594:
1587:
1579:
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1570:
1565:
1561:
1557:
1553:
1546:
1538:
1534:
1529:
1524:
1520:
1516:
1513:(1–2): 1–11.
1512:
1508:
1507:
1502:
1495:
1487:
1483:
1478:
1473:
1469:
1465:
1461:
1457:
1453:
1446:
1438:
1434:
1429:
1424:
1419:
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1410:
1406:
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1061:
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1017:
1012:
1009:(3): 180–96.
1008:
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993:
985:
981:
976:
971:
966:
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790:
786:
779:
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768:
764:
759:
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750:
746:
743:(6): 753–67.
742:
738:
734:
727:
719:
715:
711:
707:
703:
699:
692:
684:
680:
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553:
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545:
542:Treatment of
535:
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513:
509:
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496:
495:endothelium.
494:
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301:
296:
294:
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286:
282:
281:Interleukin 6
278:
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270:
266:
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258:
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246:
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238:
233:
231:
227:
223:
219:
215:
214:vascular tone
211:
206:
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196:
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183:
173:
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159:February 2022
152:
148:
142:
139:This article
137:
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127:
113:
109:
98:
95:
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88:
84:
81:
77:
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67: –
66:
62:
61:Find sources:
56:
52:
46:
45:
41:
37:
32:This article
30:
21:
20:
2023:
2019:
2009:
1987:(1): 21–32.
1984:
1980:
1974:
1947:
1943:
1933:
1906:
1902:
1892:
1857:
1853:
1843:
1808:
1804:
1769:(6): 573–9.
1766:
1762:
1756:
1721:
1717:
1707:
1685:(1): 45–56.
1682:
1678:
1672:
1645:
1641:
1631:
1605:10.3791/2167
1596:
1586:
1559:
1555:
1545:
1510:
1504:
1494:
1462:(1): H2–12.
1459:
1455:
1445:
1408:
1404:
1394:
1369:
1363:
1323:(1): 42–60.
1320:
1316:
1259:
1252:
1209:
1205:
1195:
1158:
1152:
1142:
1115:
1109:
1055:
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1006:
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992:
955:
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941:
904:
900:
854:
850:
792:
788:
740:
736:
726:
701:
697:
691:
654:
648:
622:shear stress
620:Endothelial
600:Prostacyclin
593:endothelial
589:Nitric oxide
544:hypertension
541:
533:
506:
497:
474:
464:
452:non-invasive
449:
426:
404:vasodilators
385:
382:Nitric oxide
364:hypertension
360:Dyslipidemia
341:Oxidized LDL
322:
300:vasodilation
297:
249:inflammation
239:, increased
234:
222:prostacyclin
207:
203:nitric oxide
194:
188:
165:
156:
140:
103:
93:
86:
79:
72:
60:
40:verification
33:
1854:Circulation
1562:(1): 13–6.
1118:: 101–113.
901:Cholesterol
737:Circulation
657:: 8563845.
559:angiotensin
433:angiography
333:macrophages
230:angiotensin
199:endothelium
34:needs more
1950:(1): 1–9.
1411:(11): 11.
1161:: 925923.
958:: 787541.
907:: 792090.
628:References
610:Endothelin
524:paclitaxel
516:restenosis
393:arterioles
352:chemotaxis
345:foam cells
285:creatinine
253:biomarkers
245:thrombosis
226:endothelin
106:April 2018
76:newspapers
2042:1524-4636
1876:0009-7322
1556:Vasc. Med
1337:1875-6212
1287:0065-2598
1226:1945-4589
1072:1076-0296
811:1999-4915
795:(1): 29.
520:iopromide
512:Sirolimus
397:exogenous
329:monocytes
2063:Category
2050:24554606
2001:22280336
1966:17583170
1884:19487593
1835:28989698
1783:19886784
1748:21709134
1699:20409832
1664:15582310
1623:20972417
1578:17451088
1537:31903788
1486:20952670
1437:17376239
1386:29596860
1372:: 7–12.
1345:22112351
1295:28035582
1244:30674709
1187:35722128
1134:25804383
1088:71334997
1080:11697708
1033:18542183
1025:18382884
984:35002720
933:24222847
871:29664811
829:33375371
767:22869857
718:20678595
683:31354915
615:Integrin
573:See also
493:coronary
389:arteries
349:monocyte
306:Research
277:ferritin
255:such as
1957:1994043
1924:9574180
1826:5624345
1739:3202150
1614:3143035
1528:7877921
1477:3023245
1428:1847451
1235:6366977
1178:9199460
975:8727904
924:3814057
879:4948849
820:7823949
789:Viruses
758:3427943
674:6636482
617:network
552:statins
427:In the
376:statins
275:(CRP),
261:D-dimer
145:Please
90:scholar
55:removed
2048:
2040:
1999:
1964:
1954:
1921:
1882:
1874:
1833:
1823:
1781:
1746:
1736:
1697:
1662:
1621:
1611:
1599:(44).
1576:
1535:
1525:
1484:
1474:
1435:
1425:
1384:
1343:
1335:
1293:
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1275:
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1175:
1132:
1086:
1078:
1070:
1031:
1023:
982:
972:
931:
921:
877:
869:
827:
817:
809:
765:
755:
716:
681:
671:
409:oxygen
374:, and
247:, and
92:
85:
78:
71:
63:
1206:Aging
1084:S2CID
1029:S2CID
875:S2CID
556:renin
508:Stent
97:JSTOR
83:books
2046:PMID
2038:ISSN
1997:PMID
1962:PMID
1880:PMID
1872:ISSN
1831:PMID
1779:PMID
1744:PMID
1695:PMID
1679:JASH
1660:PMID
1619:PMID
1574:PMID
1533:PMID
1482:PMID
1433:PMID
1382:PMID
1341:PMID
1333:ISSN
1291:PMID
1283:ISSN
1273:ISBN
1240:PMID
1222:ISSN
1183:PMID
1130:PMID
1076:PMID
1068:ISSN
1021:PMID
980:PMID
929:PMID
905:2013
867:PMID
825:PMID
807:ISSN
763:PMID
714:PMID
679:PMID
655:2019
565:and
546:and
443:and
391:and
362:and
331:and
224:and
69:news
38:for
2028:doi
1989:doi
1952:PMC
1919:PMC
1911:doi
1862:doi
1858:119
1821:PMC
1813:doi
1771:doi
1734:PMC
1726:doi
1722:174
1687:doi
1650:doi
1609:PMC
1601:doi
1564:doi
1523:PMC
1515:doi
1472:PMC
1464:doi
1460:300
1423:PMC
1413:doi
1374:doi
1370:119
1325:doi
1265:doi
1230:PMC
1214:doi
1173:PMC
1163:doi
1120:doi
1116:151
1060:doi
1011:doi
970:PMC
960:doi
919:PMC
909:doi
859:doi
815:PMC
797:doi
753:PMC
745:doi
741:126
706:doi
669:PMC
659:doi
477:FDA
472:.
435:of
189:In
149:to
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2044:.
2036:.
2024:34
2022:.
2018:.
1995:.
1983:.
1960:.
1946:.
1942:.
1917:.
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