468:
collaborative research with R. James
Kirkpatrick, he investigated the 29Si magic-angle sample-spinning NMR spectra of a wide range of natural and synthetic silicates, showing that both Si-O bond length-chemical shift and bond strength-chemical shift relationships were useful tools for investigating the structures of crystalline silicates and, more importantly, silicate glasses, clays, and zeolites that cannot be examined by single crystal X-ray or neutron diffraction methods. He also worked on investigating Pt/Ru direct methanol oxidation fuel cell catalysts using 13C and 195Pt NMR, in collaboration with A. Wieckowksi, which clarified the mechanism of enhanced CO tolerance in Pt/Ru versus pure Pt catalysts.
450:
due to folding remained unexplained until 1993 when he showed that 13C and 15N chemical shifts in proteins could be well predicted by using quantum chemical methods. He reasoned that since the chemical shift is essentially a local phenomenon, it might be possible to compute chemical shifts just by using small peptide fragments and a “locally dense” basis set, and this turned out to be correct. His early work also led to the demonstration that computed chemical shift tensors could be used in protein structure refinement. Moreover, he showed that the chemical shifts of non-native species in proteins such as 19F nuclei, could be also be computed, and were due to electric field effects.
520:
tumor cells and in mice, by targeting protein prenylation with inhibition of protein prenylation also leading to activity as vaccine adjuvants. Mechanistically, FPPS inhibition affects cell signaling, but it also leads to accumulation of isopentenyl diphosphate and dimethylallyl diphosphate, compounds that activate γδT cells by binding to butyrophilins in target cells and this T cell activation led to tumor cell killing. His group also showed that some clinically used bisphosphonate drugs are converted to analogs of adenosine triphosphate that function by inhibiting cell signaling pathways.
372:
and since then has been the
Harriet A. Harlin Professor of Chemistry. He has also been a professor of biophysics in the Center for Computational Biology and Biophysics since 1995 and was a Fellow in the Center for Advanced Study in 1979, a Richard G. and Carole J. Cline University Senior Scholar in 1995, and an Associate in the Center for Advanced Study in 2000. He has authored 450 publications and as of 2023, has an h-index of 104 with 35,000 citations, according to Google Scholar and holds nine issued
441:
proteins and sterol molecules such as cholesterol. In addition, he developed 1H and 13C magic-angle sample-spinning methods to investigate lipid membranes without the need for isotopic labeling. The magic-angle technique was not thought to be applicable to 1H NMR (due to strong dipolar interactions), but he showed that due to fast axial diffusion, these interactions were scaled and that remarkably high-resolution spectra could be obtained.
31:
623:
L. Yuan, X. Ma, Y. Yang, Y. Qu, X. Li, X. Zhu, W. Ma, J. Duan, J. Xue, H. Yang, J-W. Huang, S. Yi, M. Zhang, N. Cai, L. Zhang, Q. Ding, K. Lai, C. Liu, L. Zhang, X. Liu, Y. Yao, S. Zhou, X. Li, P. Shen, Q. Chang, S. R. Malwal, Y. He, W. Li, C. Chen, C-C. Chen, E. Oldfield, R-T. Guo, Y. Zhang. Nature.
528:
Oldfield and his collaborators have reported the structures and mechanisms of action of many proteins involved in isoprenoid biosynthesis, focusing on the modular structures found. They successfully predicted the αβγ tri-domain found in diterpene cyclases. Furthermore, they used electron paramagnetic
608:
G. Benaim, J. M. Sanders, Y. Garcia-Marchán, C. Colina, R. Lira, A. R. Caldera, G. Payares, C. Sanoja, J. M. Burgos, A. Leon-Rossell, J. L. Concepcion, A. Schijman, M. Levin and E. Oldfield and J. A. Urbina, J. Med. Chem., 49, 892–899 (2006). Amiodarone has intrinsic anti-Trypanosoma cruzi activity
519:
In 2012, Oldfield's group synthesized lipophilic analogs of the clinical bisphosphonate drugs zoledronate and risedronate, to prevent unwanted binding to bone mineral, and found they had potent anti-malarial activity. Additionally, they had potent activity in a combination therapy with rapamycin in
449:
In the early 1970s, while working with Adam
Allerhand, Oldfield reported the first high-resolution 13C NMR spectra of proteins—lysozyme, myoglobin and cytochrome c—in which numerous single carbon atom sites could be resolved and assigned. The origins of the chemical shift non-equivalencies observed
371:
Oldfield joined the
Department of Chemistry at the University of Illinois at Urbana-Champaign in 1975 as an assistant Professor of Chemistry. He was promoted to associate professor in 1980 and was a Professor from 1982 to 2002. He was then an Alumni Research Professor of Chemistry from 2003 to 2013
510:
and in mice models of infection finding potent activity against the protein target dehydrosqualene synthase, the bacterium, and in a mice model of infection. His group also showed that some drugs and drug leads that target tuberculosis bacteria function as protonophore uncouplers and in some cases
601:
J. Forbes, J. Bowers, L. Moran, X. Shan, E. Oldfield, and M. A. Moscarello, J. Chem. Soc., Faraday
Transactions, 84, 3821–3849 (1988). Some new developments in solid-state nuclear magnetic resonance spectroscopic studies of lipids and biological membranes, including the effects of cholesterol in
458:
Followed by the observation that chemical shifts in proteins could be computed by using quantum chemical methods, Oldfield began a series of investigations of other spectroscopic properties including Mössbauer isomer shifts and quadrupole splittings, hyperfine shifts in metalloproteins, spin-spin
1756:
Li, Kai; Schurig-Briccio, Lici A.; Feng, Xinxin; Upadhyay, Ashutosh; Pujari, Venugopal; Lechartier, Benoit; Fontes, Fabio L.; Yang, Hongliang; Rao, Guodong; Zhu, Wei; Gulati, Anmol; No, Joo Hwan; Cintra, Giovana; Bogue, Shannon; Liu, Yi-Liang; Molohon, Katie; Orlean, Peter; Mitchell, Douglas A.;
440:
In the 1970s and 1980s
Oldfield developed ways to investigate lipid and membrane structure including the use of 2H nuclear magnetic resonance (NMR) spectroscopy of labelled compounds. This method enabled the determination of the static and dynamic structures of lipids, and how they interact with
1924:
Xia, Yun; Xie, Yonghua; Yu, Zhengsen; Xiao, Hongying; Jiang, Guimei; Zhou, Xiaoying; Yang, Yunyun; Li, Xin; Zhao, Meng; Li, Liping; Zheng, Mingke; Han, Shuai; Zong, Zhaoyun; Meng, Xianbin; Deng, Haiteng; Ye, Huahu; Fa, Yunzhi; Wu, Haitao; Oldfield, Eric; Hu, Xiaoyu; Liu, Wanli; Shi, Yan; Zhang,
505:
contains a gold-colored virulence factor called staphyloxanthin that protects the bacterium from killing by reactive oxygen species. Recognizing that the biosynthesis of the carotenoid pigment had similarities to the first steps in cholesterol biosynthesis, he synthesized a range of cholesterol
1635:
Benaim, Gustavo; Sanders, John M.; Garcia-Marchán, Yael; Colina, Claudia; Lira, Renee; Caldera, Aura R.; Payares, Gilberto; Sanoja, Cristina; Burgos, Juan Miguel; Leon-Rossell, Annette; Concepcion, Juan Luis; Schijman, Alejandro G.; Levin, Mariano; Oldfield, Eric; Urbina, Julio A. (2006).
467:
Oldfield began to investigate structures of a variety of inorganic solids in the 1980s. He showed that high-resolution spectra of quadrupolar nuclei (such as 17O, 23Na) could be obtained by using variable-angle sample-spinning, spin echo, as well as spectral deconvolution methods. In his
491:
used clinically to treat bone resorption diseases, killed these parasites. as well as others. He also discovered that the bisphosphonate pamidronate cured mice of leishmaniasis and proposed that farnesyl diphosphate synthase (FPPS) can be used as the target of bisphosphonate drugs
1966:
Yuan, Linjie; Ma, Xianqiang; Yang, Yunyun; Li, Xin; Ma, Weiwei; Yang, Haoyu; Huang, Jian-Wen; Xue, Jing; Yi, Simin; Zhang, Mengting; Cai, Ningning; Ding, Qingyang; Li, Liping; Duan, Jianxin; Malwal, Satish; Chen, Chun-Chi; Oldfield, Eric; Guo, Rey-Ting; Zhang, Yonghui (2022).
529:
resonance and X-ray crystallography to develop the organometallic mechanism of action of the unusual 4Fe-4S proteins IspG and IspH involved in the early stages of isoprenoid biosynthesis, and also used X-ray methods for providing mechanisms of action for the terpene cyclases.
1522:
Martin, Michael B.; Grimley, Joshua S.; Lewis, Jared C.; Heath, Huel T.; Bailey, Brian N.; Kendrick, Howard; Yardley, Vanessa; Caldera, Aura; Lira, Renee; Urbina, Julio A.; Moreno, Silvia N. J.; Docampo, Roberto; Croft, Simon L.; Oldfield, Eric (March 1, 2001).
1075:"Chemical shifts in proteins: a shielding trajectory analysis of the fluorine nuclear magnetic resonance spectrum of the Escherichia coli galactose binding protein using a multipole shielding polarizability-local reaction field-molecular dynamics approach"
810:
2169:
Cao, Rong; Zhang, Yonghui; Mann, Francis M.; Huang, Cancan; Mukkamala, Dushyant; Hudock, Michael P.; Mead, Matthew E.; Prisic, Sladjana; Wang, Ke; Lin, Fu-Yang; Chang, Ting-Kai; Peters, Reuben J.; Oldfield, Eric (2010).
1480:
Urbina, Julio A.; Moreno, Benjamin; Vierkotter, Stephanie; Oldfield, Eric; Payares, Gilberto; Sanoja, Cristina; Bailey, Brian N.; Yan, Wen; Scott, David A.; Moreno, Silvia N. J.; Docampo, Roberto (November 19, 1999).
620:
W. Wang and E. Oldfield, Angew. Chem. Int. Ed. Engl., 53, 4294–4310 (2014). Bioorganometallic chemistry with IspG and IspH: structure, function, and inhibition of the proteins involved in isoprenoid biosynthesis.
2268:
Chen, Chun-Chi; Malwal, Satish R.; Han, Xu; Liu, Weidong; Ma, Lixin; Zhai, Chao; Dai, Longhai; Huang, Jian-Wen; Shillo, Alli; Desai, Janish; Ma, Xianqiang; Zhang, Yonghui; Guo, Rey-Ting; Oldfield, Eric (2021).
476:
In 1999, Oldfield shifted his research to more biomedical applications. Working in collaboration with Julio Urbina and
Roberto Docampo, his group found, using 31P NMR spectroscopy, that the parasitic protozoan
2070:
Malwal, Satish R.; o'Dowd, Bing; Feng, Xinxin; Turhanen, Petri; Shin, Christopher; Yao, Jiaqi; Kim, Boo Kyung; Baig, Noman; Zhou, Tianhui; Bansal, Sandhya; Khade, Rahul L.; Zhang, Yong; Oldfield, Eric (2018).
1874:
Xia, Yifeng; Liu, Yi-Liang; Xie, Yonghua; Zhu, Wei; Guerra, Francisco; Shen, Shen; Yeddula, Narayana; Fischer, Wolfgang; Low, William; Zhou, Xiaoying; Zhang, Yonghui; Oldfield, Eric; Verma, Inder M. (2014).
612:
C.-I. Liu, G. Y. Liu, Y. Song, F. Yin, M. E. Hensler, W.-Y. Jeng, V. Nizet, A. H.-J. Wang and E. Oldfield, Science, 319, 1391–1394 (2008). A cholesterol biosynthesis inhibitor blocks
Staphylococcus aureus
616:
Y. Xia, N. Yeddula, M. Leblanc, E. Ke, Y. Zhang, E. Oldfield, R. J. Shaw and I. M. Verma, Nature Cell
Biology, 14, 257–265 (2012). Reduced cell proliferation by IKK2/IKKb depletion in a mouse lung cancer
1806:
No, Joo Hwan; De Macedo Dossin, Fernando; Zhang, Yonghui; Liu, Yi-Liang; Zhu, Wei; Feng, Xinxin; Yoo, Jinyoung Anny; Lee, Eunhae; Wang, Ke; Hui, Raymond; Freitas-Junior, Lucio H.; Oldfield, Eric (2012).
598:
M. D. Meadows, K. A. Smith, R. A. Kinsey, T. M. Rothgeb, R. P. Skarjune and E. Oldfield, Proc. Natl. Acad. Sci. U.S.A., 79, 1351–1355 (1982), High-resolution solid state NMR of quadrupolar nuclei
858:"Some new developments in solid-state nuclear magnetic resonance spectroscopic studies of lipids and biological membranes, including the effects of cholesterol in model and natural systems"
499:, the antiarrhythmic drug amiodarone, and that it acted synergistically with the azole drug posaconazole. He then began to investigate antibacterial agents. The human pathogen
605:
A. C. de Dios, J. G. Pearson and E. Oldfield, Science, 260, 1491–1496 (1993). Secondary and tertiary structural effects on protein NMR chemical shifts: An ab initio approach.
1757:
Freitas-Junior, Lucio; Ren, Feifei; Sun, Hong; Jiang, Tong; Li, Yujie; Guo, Rey-Ting; Cole, Stewart T.; Gennis, Robert B.; Crick, Dean C.; Oldfield, Eric (April 10, 2014).
928:"Cytochrome c. Observation of Numerous Single-Carbon Sites of the Reduced and Oxidized Species by Means of Natural-Abundance 13C Nuclear Magnetic Resonance Spectroscopy"
2019:
Zhou, Xiaoying; Gu, Yanzheng; Xiao, Hongying; Kang, Ning; Xie, Yonghua; Zhang, Guangbo; Shi, Yan; Hu, Xiaoyu; Oldfield, Eric; Zhang, Xueguang; Zhang, Yonghui (2017).
2414:
772:"Spectroscopic studies of specifically deuterium labeled membrane systems. Nuclear magnetic resonance investigation of the effects of cholesterol in model systems"
400:
NMR methods led to new ways to study the structures of lipids and membranes; his carbon-13 NMR and quantum chemical developments led to new ways to investigate
1441:
355:
in 1972, with Dennis
Chapman, developing NMR methods to study lipid and membrane structure. He worked as a Research Associate and EMBO Postdoctoral Fellow at
1809:"Lipophilic analogs of zoledronate and risedronate inhibit Plasmodium geranylgeranyl diphosphate synthase (GGPPS) and exhibit potent antimalarial activity"
2221:"Bioorganometallic Chemistry with IspG and IspH: Structure, Function, and Inhibition of the [Fe4S4] Proteins Involved in Isoprenoid Biosynthesis"
304:
2424:
1699:
Liu, Chia-I; Liu, George Y.; Song, Yongcheng; Yin, Fenglin; Hensler, Mary E.; Jeng, Wen-Yih; Nizet, Victor; Wang, Andrew H.-J.; Oldfield, Eric (2008).
2429:
889:"Natural-abundance carbon-13 nuclear magnetic resonance studies in 20-mm sample tubes. Numerous single-carbon resonances of hen egg-white lysozyme"
2444:
1455:
Babu, P. K.; Oldfield, E.; Wieckowski, A. (March 17, 2003). Vayenas, C. G.; Conway, B. E.; White, Ralph E.; Gamboa-Adelco, Maria E. (eds.).
2439:
1194:"Mössbauer Quadrupole Splittings and Electronic Structure in Heme Proteins and Model Systems: A Density Functional Theory Investigation"
260:
183:
377:
359:
with Adam Allerhand, on the development of high-resolution NMR of proteins (1972–1974) and was then a Visiting Scientist at MIT with
2362:
1483:"Trypanosoma cruzi Contains Major Pyrophosphate Stores, and Its Growth in Vitro and in Vivo Is Blocked by Pyrophosphate Analogs *"
264:
95:
2419:
1685:
84:
2326:
1686:"Staphylococcus aureus golden pigment impairs neutrophil killing and promotes virulence through its antioxidant activity"
1969:"Phosphoantigens are Molecular Glues that Promote Butyrophilin 3A1/2A1 Association Leading to Vγ9Vδ2 T Cell Activation"
2344:
2434:
2021:"Combining Vγ9Vδ2 T Cells with a Lipophilic Bisphosphonate Efficiently Kills Activated Hepatic Stellate Cells"
579:
2006 – Campus Award for Excellence in Guiding Undergraduate Research, University of Illinois Urbana-Champaign
1877:"A combination therapy for KRAS-driven lung adenocarcinomas using lipophilic bisphosphonates and rapamycin"
1303:"The Chemical Nature of Hydrogen Bonding in Proteins via NMR: J-Couplings, Chemical Shifts, and AIM Theory"
1597:
1598:"Nitrogen-Containing Bisphosphonates as Carbocation Transition State Analogs for Isoprenoid Biosynthesis"
1364:
292:
126:
459:
couplings, and electric field gradients, as well as the effects of hydrogen bonding on chemical shifts.
347:
on lipids and isoprenoids. He graduated with a Bachelor of Science degree in 1969. He obtained a PhD in
1968:
624:
2023 Sep; 621(7980): 840–848. Phosphoantigens glue butyrophilin 3A1 and 2A1 to activate Vγ9Vδ2 T cells.
574:
552:
308:
144:
113:
1638:"Amiodarone Has Intrinsic Anti-Trypanosoma cruzi Activity and Acts Synergistically with posaconazole†"
857:
1442:"High-resolution silicon-29 nuclear magnetic resonance spectroscopic study of rock-forming silicates"
568:
312:
130:
2005:
754:"deuteron resonance:A novel approach to the study of hydrocarbon chain mobility in membrane systems"
2308:
856:
Forbes, Jeffrey; Bowers, John; Shan, Xi; Moran, Liam; Oldfield, Eric; Moscarello, Mario A. (1988).
717:
1024:
Wylie, Benjamin J.; Schwieters, Charles D.; Oldfield, Eric; Rienstra, Chad M. (January 28, 2009).
979:"Secondary and Tertiary Structural Effects on Protein NMR Chemical Shifts: an ab Initio Approach"
539:
352:
296:
280:
109:
2404:
1155:"57Fe Mössbauer Isomer Shifts of Heme Protein Model Systems: Electronic Structure Calculations"
862:
Journal of the Chemical Society, Faraday Transactions 1: Physical Chemistry in Condensed Phases
1596:
Martin, Michael B.; Arnold, William; Heath, Huel T.; Urbina, Julio A.; Oldfield, Eric (1999).
699:
1992:
1482:
501:
348:
336:
215:
2409:
2380:
1820:
1712:
1407:
990:
673:
74:
978:
8:
1233:"Nuclear Magnetic Resonance Shifts in Paramagnetic Metalloporphyrins and Metalloproteins"
586:
562:
511:
they can also target isoprenoid biosynthesis, leading to potent multi-target inhibition.
388:
Oldfield is known for his research in nuclear magnetic resonance (NMR) spectroscopy, and
139:
122:
2270:
1824:
1716:
1583:"Radical Cure of Experimental Cutaneous Leishmaniasis by the Bisphosphonate Pamidronate"
1582:
1411:
994:
677:
2290:
2245:
2220:
2196:
2171:
2146:
2121:
2097:
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2020:
1980:
1901:
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1808:
1783:
1758:
1733:
1700:
1423:
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838:
356:
332:
161:
79:
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927:
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2250:
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2052:
1984:
1948:
1906:
1848:
1788:
1738:
1667:
1617:
1564:
1504:
1380:
1333:
1272:"Computation of Through-Space 19F−19F Scalar Couplings via Density Functional Theory"
1252:
1213:
1174:
1135:
1055:
1006:
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908:
830:
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344:
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1972:
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1314:
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1205:
1166:
1125:
1117:
1086:
1074:
1045:
1037:
998:
949:
939:
900:
888:
869:
822:
783:
771:
736:"Eric Oldfield Inventions, Patents and Patent Applications – Justia Patents Search"
681:
429:
202:
165:
1892:
1637:
1365:"Solid-state spin-echo Fourier transform NMR of 39K and 67Zn salts at high field"
1302:
1271:
1232:
1193:
1154:
582:
2009 – Award in Soft Matter and Biophysical Chemistry, Royal Society of Chemistry
417:
770:
Oldfield, Eric; Meadows, Michael; Rice, David; Jacobs, Russell (July 11, 1978).
1943:
1926:
753:
558:
488:
484:
389:
300:
241:
118:
99:
59:
2271:"Terpene Cyclases and Prenyltransferases: Structures and Mechanisms of Action"
1976:
826:
2398:
2286:
2037:
1927:"The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery"
1701:"A Cholesterol Biosynthesis Inhibitor Blocks Staphylococcus aureus Virulence"
1524:
1499:
360:
225:
1833:
1724:
1466:
1394:
Oldfield, Eric; Timken, Hye Kyung C.; Montez, Ben; Ramachandran, R. (1985).
1073:
Pearson, John G.; Oldfield, Eric; Lee, Frederick S.; Warshel, Arieh (1993).
1002:
944:
2254:
2236:
2205:
2155:
2137:
2106:
2056:
1952:
1910:
1852:
1792:
1759:"Multitarget Drug Discovery for Tuberculosis and Other Infectious Diseases"
1742:
1671:
1621:
1613:
1568:
1508:
1395:
1256:
1217:
1178:
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1121:
1059:
487:, contained very high levels of diphosphate, and that diphosphate analogs,
409:
288:
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173:
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1010:
963:
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has led to the development of new therapeutic approaches to treating both
136:
Award in Soft Matter and Biophysical Chemistry, Royal Society of Chemistry
2088:
873:
834:
811:"Deuterium magnetic resonance: theory and application to lipid membranes"
795:
1090:
904:
787:
2187:
1662:
1270:
Arnold, William D.; Mao, Junhong; Sun, Haihong; Oldfield, Eric (2000).
291:. He has received a number of recognitions for his work, including the
256:
2073:"Bisphosphonate-Generated ATP-Analogs Inhibit Cell Signaling Pathways"
1774:
1653:
1560:
1318:
1287:
1248:
1209:
1170:
1110:
Philosophical Transactions of the Royal Society B: Biological Sciences
1041:
1419:
1349:
1192:
Zhang, Yong; Mao, Junhong; Godbout, Nathalie; Oldfield, Eric (2002).
421:
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393:
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276:
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548:
1979 – Research Career Development Award, U.S. Public Health Service
272:
660:
Allerhand, Adam; Childers, RayF; Oldfield, Eric (August 1, 1973).
404:; his investigations of quadrupolar nuclei led to new research in
196:"Spectroscopic Studies of Lipids and Biological Membranes" (1972)
1634:
1332:
Ganapathy, Subramanian; Schramm, Suzanne; Oldfield, Eric (1982).
1026:"Protein Structure Refinement Using 13 Cα Chemical Shift Tensors"
328:
244:
48:
1393:
30:
1023:
425:
397:
373:
324:
268:
190:
44:
1479:
1334:"Variable-angle sample-spinning high resolution NMR of solids"
1755:
662:"Carbon-13 fourier transform nmr at 14.2 kg in a 20 mm probe"
2069:
977:
De Dios, Angel C.; Pearson, John G.; Oldfield, Eric (1993).
416:, and his more recent research using NMR, computational and
1805:
887:
Allerhand, Adam; Childres, Ray F.; Oldfield, Eric (1973).
1072:
886:
769:
659:
2172:"Diterpene cyclases and the nature of the isoprene fold"
1331:
1595:
1521:
1396:"High-resolution solid-state NMR of quadrupolar nuclei"
1191:
1454:
976:
495:
Oldfield then discovered another compound that killed
1363:
Kunwar, A.C; Turner, Gary L.; Oldfield, Eric (1986).
855:
1362:
1269:
1602:
Biochemical and Biophysical Research Communications
305:
American Association for the Advancement of Science
293:
American Chemical Society's Award in Pure Chemistry
1231:Mao, Junhong; Zhang, Yong; Oldfield, Eric (2002).
1153:Zhang, Yong; Mao, Junhong; Oldfield, Eric (2002).
2176:Proteins: Structure, Function, and Bioinformatics
2168:
925:
134:Award in Spectroscopy, Royal Society of Chemistry
2396:
2267:
1230:
1152:
2415:University of Illinois Urbana-Champaign faculty
1813:Proceedings of the National Academy of Sciences
1106:"Quantum chemical studies of protein structure"
932:Proceedings of the National Academy of Sciences
2309:"RSC Awards Archive – Meldola Medal and Prize"
2018:
1300:
435:
2363:"Soft Matter and Biophysical Chemistry Award"
1698:
2218:
1965:
1923:
1873:
643:"Eric Oldfield | Chemistry at Illinois"
2119:
1301:Arnold, William D.; Oldfield, Eric (2000).
609:and acts synergistically with posaconazole.
551:1980 – Katz Basic Science Research Prize,
506:biosynthesis inhibitors and tested them in
318:
2381:"Society Awards – The Biophysical Society"
1545: : A Potential Route to Chemotherapy"
297:Royal Society of Chemistry's Meldola Medal
261:University of Illinois at Urbana-Champaign
184:University of Illinois at Urbana-Champaign
29:
2425:Fellows of the Royal Society of Chemistry
2244:
2195:
2145:
2096:
2046:
2036:
1942:
1900:
1842:
1832:
1782:
1732:
1661:
1498:
1458:Modern Aspects of Electrochemistry No. 36
1129:
1049:
953:
943:
514:
378:United States Patent and Trademark Office
363:(1974-1975), working on solid-state NMR.
2430:Fellows of the American Physical Society
2122:"Terpene Biosynthesis: Modularity Rules"
2077:Journal of the American Chemical Society
1307:Journal of the American Chemical Society
1276:Journal of the American Chemical Society
1237:Journal of the American Chemical Society
1198:Journal of the American Chemical Society
1159:Journal of the American Chemical Society
1103:
1079:Journal of the American Chemical Society
1030:Journal of the American Chemical Society
926:Oldfield, Eric; Allerhand, Adam (1973).
2225:Angewandte Chemie International Edition
2126:Angewandte Chemie International Edition
1525:"Bisphosphonates Inhibit the Growth of
523:
462:
265:nuclear magnetic resonance spectroscopy
2397:
808:
2445:Alumni of the University of Sheffield
2219:Wang, Weixue; Oldfield, Eric (2014).
2120:Oldfield, Eric; Lin, Fu-Yang (2012).
85:Massachusetts Institute of Technology
592:
453:
301:Biochemical Society's Colworth Medal
2440:Alumni of the University of Bristol
585:2011 – Avanti Award in Lipids, The
13:
444:
14:
2456:
331:on May 23, 1948. He attended the
700:"Chemistry Tree - John S. Waugh"
567:1984 – Award in Pure Chemistry,
2373:
2355:
2337:
2319:
2301:
2261:
2212:
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2113:
2063:
2012:
1959:
1917:
1867:
1799:
1749:
1692:
1678:
1628:
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1515:
1487:Journal of Biological Chemistry
1473:
1448:
1434:
1387:
1356:
1338:The Journal of Chemical Physics
1325:
1294:
1263:
1224:
1185:
1146:
1097:
1066:
1017:
970:
919:
880:
815:Quarterly Reviews of Biophysics
545:1978 -Sloan Research Fellowship
1881:Science Translational Medicine
1763:Journal of Medicinal Chemistry
1642:Journal of Medicinal Chemistry
1549:Journal of Medicinal Chemistry
1461:. Springer US. pp. 1–50.
849:
802:
763:
746:
728:
710:
692:
653:
635:
573:1995 – Award in Spectroscopy,
471:
263:. He is known for his work in
87:(Visiting Scientist 1974–1975)
1:
2420:20th-century English chemists
1369:Journal of Magnetic Resonance
666:Journal of Magnetic Resonance
628:
1893:10.1126/scitranslmed.3010382
1381:10.1016/0022-2364(86)90224-6
686:10.1016/0022-2364(73)90013-9
542:, Royal Society of Chemistry
303:, and he is a member of the
212:Other academic advisors
7:
436:NMR of lipids and membranes
383:
10:
2461:
2367:Royal Society of Chemistry
1944:10.1016/j.cell.2018.08.070
1469:– via Springer Link.
688:– via ScienceDirect.
602:model and natural systems.
575:Royal Society of Chemistry
553:American Heart Association
309:Royal Society of Chemistry
279:; of inorganic solids; in
145:American Heart Association
143:Katz Basic Science Prize,
114:Royal Society of Chemistry
2349:American Chemical Society
1977:10.1101/2022.01.02.474068
827:10.1017/S0033583500002948
569:American Chemical Society
532:
483:, the causative agent of
366:
313:American Physical Society
231:
211:
201:
189:
179:
157:
150:
131:American Chemical Society
105:
91:
65:
55:
37:
28:
21:
2287:10.1021/acscatal.0c04710
2038:10.3389/fimmu.2017.01381
1511:– via www.jbc.org.
1500:10.1074/jbc.274.47.33609
809:Seelig, Joachim (1977).
418:crystallographic methods
319:Early life and education
247:, the Harriet A. Harlin
138:Avanti Award in Lipids,
72:(B.Sc. 1969; D.Sc. 1982)
2025:Frontiers in Immunology
1834:10.1073/pnas.1118215109
1725:10.1126/science.1153018
1467:10.1007/0-306-47927-3_1
1104:Oldfield, Eric (2005).
1003:10.1126/science.8502992
945:10.1073/pnas.70.12.3531
353:University of Sheffield
281:computational chemistry
127:Award in Pure Chemistry
2435:Scientists from London
2237:10.1002/anie.201306712
2138:10.1002/anie.201103110
2000:Cite journal requires
1614:10.1006/bbrc.1999.1404
1543:Plasmodium f alciparum
1122:10.1098/rstb.2003.1421
647:chemistry.illinois.edu
515:Anti-cancer drug leads
311:, and a Fellow of the
502:Staphylococcus aureus
349:Biophysical Chemistry
333:University in Bristol
323:Oldfield was born in
2331:www.biochemistry.org
2327:"The Colworth Medal"
2089:10.1021/jacs.8b02363
1937:(4): 1059–1073.e21.
1535:Leishmania d onovani
874:10.1039/F19888403821
524:Isoprenoid synthesis
463:NMR inorganic solids
335:doing research with
82:(Post-Doc 1972–1974)
75:Sheffield University
1825:2012PNAS..109.4058N
1717:2008Sci...319.1391L
1711:(5868): 1391–1394.
1493:(47): 33609–33615.
1412:1985Natur.318..163O
1313:(51): 12835–12841.
1282:(49): 12164–12168.
1243:(46): 13911–13920.
1204:(46): 13921–13930.
1116:(1458): 1347–1361.
1091:10.1021/ja00068a049
995:1993Sci...260.1491D
989:(5113): 1491–1496.
905:10.1021/bi00731a013
788:10.1021/bi00607a006
678:1973JMagR..11..272A
587:Biophysical Society
563:Biochemical Society
422:infectious diseases
392:. His invention of
255:and a professor of
140:Biophysical Society
123:Biochemical Society
2385:www.biophysics.org
2188:10.1002/prot.22751
1539:Toxoplasma g ondii
1527:Trypanosoma brucei
740:patents.justia.com
722:scholar.google.com
559:The Colworth Medal
430:lipid biosynthesis
402:protein structures
357:Indiana University
307:, a Fellow of the
162:Physical Chemistry
80:Indiana University
70:Bristol University
2345:"Past Recipients"
2231:(17): 4294–4310.
2182:(11): 2417–2432.
2083:(24): 7568–7578.
1887:(263): 263ra161.
1819:(11): 4058–4063.
1775:10.1021/jm500131s
1654:10.1021/jm050691f
1561:10.1021/jm0002578
1531:Trypanosoma cruzi
1406:(6042): 163–165.
1319:10.1021/ja0025705
1288:10.1021/ja002361k
1249:10.1021/ja020297w
1210:10.1021/ja020298o
1171:10.1021/ja011583v
1165:(26): 7829–7839.
1085:(15): 6851–6862.
1042:10.1021/ja804041p
938:(12): 3531–3535.
782:(14): 2727–2740.
593:Selected articles
540:The Meldola Medal
480:Trypanosoma cruzi
454:Quantum chemistry
406:materials science
345:Geoffrey Eglinton
240:(born 1948) is a
235:
234:
220:Geoffrey Eglinton
152:Scientific career
110:The Meldola Medal
2452:
2389:
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2132:(5): 1124–1137.
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2016:
2010:
2009:
2003:
1998:
1996:
1988:
1963:
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1946:
1925:Yonghui (2018).
1921:
1915:
1914:
1904:
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1864:
1846:
1836:
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1420:10.1038/318163a0
1391:
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1360:
1354:
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1350:10.1063/1.444436
1344:(9): 4360–4365.
1329:
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1261:
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1228:
1222:
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1021:
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974:
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799:
767:
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760:
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743:
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714:
708:
707:
704:academictree.org
696:
690:
689:
657:
651:
650:
639:
203:Doctoral advisor
166:Chemical Biology
96:NMR Spectroscopy
33:
19:
18:
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1918:
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807:
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768:
764:
756:
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751:
747:
734:
733:
729:
718:"Eric Oldfield"
716:
715:
711:
698:
697:
693:
658:
654:
641:
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636:
631:
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535:
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489:bisphosphonates
474:
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456:
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445:NMR of proteins
438:
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321:
224:
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142:
137:
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83:
78:
73:
51:
42:
24:
17:
16:British chemist
12:
11:
5:
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2062:
2011:
2002:|journal=
1958:
1916:
1866:
1798:
1748:
1691:
1677:
1648:(3): 892–899.
1627:
1608:(3): 754–758.
1588:
1574:
1555:(6): 909–916.
1514:
1472:
1447:
1433:
1386:
1355:
1324:
1293:
1262:
1223:
1184:
1145:
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1036:(3): 985–992.
1016:
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801:
762:
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691:
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485:Chagas disease
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390:drug discovery
385:
382:
368:
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337:Jake MacMillan
320:
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233:
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229:
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223:Adam Allerhand
216:Jake MacMillan
213:
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207:Dennis Chapman
205:
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177:
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159:
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119:Colworth Medal
107:
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100:Drug Discovery
93:
92:Known for
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2275:ACS Catalysis
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20:
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2014:
1993:cite journal
1961:
1934:
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893:Biochemistry
892:
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868:(11): 3821.
865:
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776:Biochemistry
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448:
439:
428:, targeting
410:geochemistry
387:
370:
322:
289:parasitology
285:microbiology
237:
236:
195:
180:Institutions
174:Parasitology
170:Microbiology
151:
77:(Ph.D. 1972)
2410:1948 births
2313:www.rsc.org
2281:: 290–303.
1663:11336/79898
1375:: 124–127.
472:Antibiotics
56:Citizenship
2399:Categories
629:References
613:virulence.
341:diterpenes
257:Biophysics
2295:230567887
1985:245705122
508:S. aureus
414:catalysis
394:deuterium
376:from the
351:from the
283:, and in
277:membranes
253:Chemistry
249:Professor
66:Education
2255:24481599
2206:20602361
2156:22105807
2107:29787268
2057:29118758
2031:: 1381.
1953:30270039
1911:25411474
1861:10108911
1853:22392982
1793:24568559
1743:18276850
1672:16451055
1622:10512752
1569:11300872
1509:10559249
1257:12431123
1218:12431124
1179:12083937
1140:16147526
1060:19123862
843:33372264
497:T. cruzi
384:Research
299:and the
273:proteins
2246:3997630
2197:3805035
2147:3769779
2098:6022752
2048:5661056
1902:4326221
1844:3306666
1821:Bibcode
1784:4084622
1734:2747771
1713:Bibcode
1705:Science
1428:4329616
1408:Bibcode
1131:1569496
1051:2751586
1011:8502992
991:Bibcode
983:Science
964:4357878
913:4735301
674:Bibcode
557:1983 –
374:patents
329:England
259:at the
245:chemist
242:British
60:British
49:England
2293:
2253:
2243:
2204:
2194:
2154:
2144:
2105:
2095:
2055:
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