Heated tobacco product

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instances, marketing materials claim that heated tobacco products are potentially helpful to smokers who want to quit. Some media accounts that announced product launches state that HTPs reduce the levels of harmful tobacco components by 90–95% compared to traditional cigarettes, while others emphasise the lack of odor or visible emissions as part of marketing campaigns; as of April 2018, there is no evidence to confirm the former claim. However, the public can perceive "lower exposure" claims as lower risk, even if no such claim was made explicitly. Other marketing claims highlight that these products produce no smoke (i.e., "smoke-free"). Implied in these claims, in advertisements and stores globally, is that smokers should switch from traditional cigarettes to these new, allegedly less harmful, products.

1624: 1864:. A representative for the company in New Zealand stated that IQOS products comply with the Smoke-Free Environments Act. Three meetings between Ministry of Health officials and people from the tobacco industry were held from 30 May 2017 through 2 June 2017 to "discuss regulation of new tobacco and nicotine-delivery products". In August 2017, the government stated they would initiate a review process before products are sold for heated tobacco products such as IQOS. In 2018, PMI and the Ministry of Health were in a legal dispute over the legality of selling IQOS in New Zealand, before a New Zealand court decided in March that the HEETs sticks used in the IQOS product are legal to sell in the country. Individuals can import heated tobacco products to New Zealand for personal use. 741:-powered systems that produce nicotine-containing emissions by heating tobacco. For this purpose, tobacco sticks are placed in a corresponding heater and heated to about 250–350 °C (around 500 °F), which result in nicotine-containing emissions that are inhaled via a mouthpiece with a filter segment. HTPs are hybrids between electronic and conventional cigarettes: they are equipped with a device that heats the product without reaching combustion to generate aerosol, while using "real" tobacco instead of nicotine-containing liquids. There are products that have a time limit so that the user is forced to inhale the nicotine within 3.5–10 minutes prior to the device turning off. This function helps support blood nicotine peaks that result in an increased 932: 1884:

device, heat-not-burn system, HnB system, heat-not-burn (HNB) device, heat-not-burn device, HNB device, HnB tobacco device, HnB device, HNB cigarette, heated cigarette, HTP cigarette, cigarette-like product, mini-cigarette, electronic heated tobacco product, electronically-heated cigarette smoking system (EHCSS), electrically heated cigarette smoking system, electrically heated tobacco system, non-combusted cigarette, non-combusted tobacco product, tobacco heating cigarette, tobacco heating product, tobacco heating system (THS), smokeless cigarette, smokeless tobacco stick, tobacco stick product, loose-leaf tobacco vaporizer (LLTV), tobacco vaporizer, or T-vapor.

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Marketing slogans like "heat-not-burn" cannot be a substitute for science. The tobacco industry has described them as "not-burned" (heat-not-burn), though it has backtracked from this claim as of 2018. HTPs are not typically marketed as a harmless substitute to smoking, though they have been marketed as a "smoke-free" alternative to traditional cigarettes, and promoted as a way to lower risk from smoking. The IQOS product has been advertised as emitting "no smoke". This advertisement claim is not a replacement for science. It is expected that the promotion associated with these products will worsen the worldwide tobacco risk.

1564: 917:, may also have led the tobacco companies to consider alternative products to protect their profits and political interests. T.L. Caputi suggests that the ubiquity of e-cigarettes and the growing dissatisfaction with not providing a "throat-hit" may present an opportunity for HTPs. Philip Morris International anticipates a future without traditional cigarettes, but campaigners and industry analysts question the probability of traditional cigarettes being overshadowed by either e-cigarettes or other products like the IQOS. 7129: 6873: 4857: 4159: 3922: 3596: 3087: 2903: 2667: 2350: 84: 8310: 767: 131: 1006: 1623: 588:

fetus is probably less than traditional smoking during pregnancy, the Committee on Toxicity recommends that expectant mothers completely stop smoking. Nicotine is harmful to the infant and the growing adolescent brain, is metabolised much faster while a woman is pregnant, easily passes through the placental barrier, and collects in breast milk. There is also growing evidence that nicotine exposure during pregnancy is linked to

7868: 43: 8320: 7772: 564:. A 2016 study found that smokers were less satisfied and had a lower reduction in cravings with using an IQOS than with traditional cigarettes. In the study, smoking trial volunteers switching to an HTP, after an initial adjustment period, usually smoked more traditional cigarettes than those not switching, while reporting that they were less satisfying and rewarding than with regular cigarettes. 1179:) launched a butane-powered product used to heat tobacco or botanical products. Later models replaced the butane heating with an electric system. The Pax 2 vaporizer uses loose plant material such as tobacco or cannabis and remains cool to the touch while the oven heats to one of four temperatures (up to 455 °F). The Pax 3 takes 15 seconds to heat up and can be used to heat cannabis flowers. 4886: 785: 1822:

adopted for HTPs in Italy: health warnings are required to cover only 30% of the heated tobacco product packaging (instead of 65% for traditional cigarettes), without pictorial images; comprehensive smoke-free regulations prohibiting smoking in all public places and workplaces do not apply to HTPs; and advertising and promotions are not banned for them. Epidemiologists Xiaoqiu Liu

944:. In addition to nicotine, they contain additives that are flavoured and derived from substances other than tobacco. Evidence shows that the concentrations of nicotine in mainstream HTP aerosols are lower than in cigarette smoke. Smokers regularly reported HTP use to be less satisfying than smoking a cigarette. Tested HTPs provided more nicotine in the aerosol than a 1757:

has been explored by some tobacco control experts in the past, with enthusiasm for the possibility of harm reduction growing with the widespread availability of e-cigarettes in certain markets. The tobacco industry frames harm reduction as a common ground with health advocates and a possible entry point to influence legislation and regulation of tobacco products.

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automatically stops the heating process after six minutes or 14 moves(puffs) so that pyrolytic products and pollutant release are limited in time as well as by a maximum number of puffs per stick. HTPs may not generate side-stream smoke because they do not fully combust, but the temperatures reached are sufficient for pyrolysis to happen.

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399 (95% CI: 184–1,490) times larger than the change in average monthly queries for e-cigarettes in the United States over the same time period, increasing by 2,956% (95% CI: 1,729–7,304) compared to only 7% (95% CI: 3–13), which indicate that interest in heat-not-burn may outpace interest in e-cigarettes in the future.

1087:. The stick is inserted into the holder which then heats it to temperatures up to 350 °C, and the amount of nicotine provided may be a little strong for light cigarette smokers. Users have reported less smell and odor on clothing. There is a limited amount of research on the effect of IQOS on the user's health. 475:

risk to bystanders where smokers were using heated tobacco products instead of smoking. Limited evidence on air emissions suggests that toxic exposure from HTPs is greater than from e-cigarettes. There is no safe level of exposure to harm carcinogens, making it difficult to assess how much HTPs reduce health risks.

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harmful emissions have been shown, but lowering the risk to the smoker who transitions to using them has not been shown, as of 2018. In 2017, the Committee on Toxicity found that HTPs do not reduce exposure or potential addiction to nicotine; some of the substances inhaled from using these products are carcinogens.

5464: 726:, to prevent the tobacco from drying out and promote aerosol formation), binders, and flavorings. The filter elements consist of two independent systems: a polymer film filter that cools the aerosol, and a soft cellulose acetate mouthpiece filter that mimics the sensory aspects of a traditional cigarette. 1777:

do not extend to include them, and in the majority of the countries in which they have been sold, they have been taxed at a lower rate than traditional cigarettes. Tobacco companies have used these products to seek exemptions and relaxations of existing tobacco control policies, and have used them in

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In October 1998, Philip Morris launched the Accord in the US. It was a specialised cigarette was designed to be used with the electric heating system. Advertisements stating reduced risk were drafted for the Accord in the US, but were never released. In 1998, the company launched the Accord in Osaka,

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There are devices that use a reaction that resembles pyrolysis or combustion, but research has not determined which of the two it is. The tobacco stick contains a compressed tobacco film made of a dried tobacco suspension that has been rolled up into a paper-thin brown tobacco foil and several filter

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The HTP consists of three components with different functions: the processed tobacco stick; a pen-like heater (holder) that the tobacco stick is inserted, which is then heated by an electrically controlled heating element; and a charger that recharges the heater after use. The heated tobacco products

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The temperature the tobacco reaches greatly varies among HTPs; it depends on the process used to heat the tobacco. For example, HeatSticks are heated to a maximum of 350 °C, a temperature sufficient to enable pyrolytic decomposition of some organic materials, while the glo iFuse heats tobacco to

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The limited data on HTP users show that they take short puffs and that the time between puffs is very short. Experimental tests show a higher volume of puffs at shorter intervals than with traditional cigarettes. A 2018 clinical trial found that tests of smokers switching to IQOS showed a tendency to

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stated that "here is limited information on product use, including whether smokers are likely to switch completely from tobacco smoking or use both types of product, as well as initiation by non-smokers (including young people)." In 2017, the Committee on Toxicity stated "he Committees were concerned

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Kotz, Daniel; Kastaun, Sabrina (2018). "E-Zigaretten und Tabakerhitzer: repräsentative Daten zu Konsumverhalten und assoziierten Faktoren in der deutschen Bevölkerung (die DEBRA-Studie)" [E-cigarettes and heat-not-burn products: representative data on consumer behaviour and associated factors in

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Due to the alleged belief in heated tobacco harm reduction in Italy, HTPs are exempted from the fiscal regimes of tobacco products. Taxes on them are reduced as much as e-cigarettes, or half of traditional cigarettes. Moreover, the enforcement of various tobacco control regulations is only minimally

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stated that the US FDA should halt new tobacco products until tobacco companies stop selling traditional cigarettes. It is recommended that indoor-smoking bans for traditional cigarettes be extended to heated tobacco products. It is recommended that marketing of these products, and claims being made

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The glo iFuse debuted in Romania in 2015, and is a hybrid of a heated tobacco product and an e-cigarette. It consists of a heating element, a liquid tank (like e-cigarettes), and a tobacco cavity through which the aerosol passes and is infused with tobacco flavour. It uses cartridges called Neopods,

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of uteroplacental vessels, which reduces the delivery of both nutrients and oxygen to the fetus. As a result, nutrition is re-distributed to prioritize vital organs, such as the heart and the brain, at the cost of less vital organs, such as the liver, kidneys, adrenal glands, and pancreas, which can

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and other harmful substances is lower than with traditional cigarettes, though reduced exposure to harmful substances does not correlate with health risk severity. Even low exposure can increase the risks for cancers, stroke, and other cardiovascular diseases compared to non-smokers. Lower levels of

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found it unclear if the use of heated tobacco products (HTPs) would "substantially alter the risk of harm" over traditional cigarettes. As of December 2017, it is impossible to quantify the health risk from using these products, as there is very limited information available on health effects. It is

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movement, leaving it without a unified voice to communicate with the public, the media and with policy makers on the strategies to advance tobacco control. The concept of harm reduction has traditionally been embraced in several public health fields such as clean needles for injectable drug use and

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Internal documents and statements by PMI researchers have contradicted PMI's claims about reduced harm in regard to the IQOS product. For example, in 2018, four PMI researchers who worked for the company stated that the lowered levels of certain substances produced by the IQOS did not automatically

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Queries for heat-not-burn in Japan occur more frequently than queries for e-cigarettes in the United States, with the Japanese heat-not-burn queries first eclipsing e-cigarette queries in April 2016. Further, the change in average monthly queries for heat-not-burn in Japan between 2015 and 2017 was

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In September 2020, Yunnan Xike Science & Technology Co., Ltd. launched Cigoo; according to the company, it is a heated herbal product which releases nicotine and aroma aerosol at 300 °C, similar to mainstream HTPs. Instead of using reconstituted tobacco film in the stick, Cigoo sticks use

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is being introduced to other countries; As of October 2019, it is available in 49 countries. PMI has projected that when 30 billions units are sold, the IQOS would increase profits by $ 700 million. In October 2018, PMI introduced a less expensive version of IQOS called IQOS 3 in Tokyo, Japan.

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As of July 2017, not many US adults had tried using an HTP; approximately one in twenty US adults (including one in ten traditional cigarette users) have heard of HTPs. In Italy, HTP use was 1.4% among the people and 3.1% among regular tobacco users. A 2018 survey in Italy found that 45 per cent of

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The availability of flavours in HTP products may appeal to non-smokers, and evidence suggests that individuals who have never used tobacco products, especially children and adolescents, could be susceptible to new products that could lead to the use of traditional cigarettes. In 2017, the Committee

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As early as the 1960s, tobacco companies developed alternative tobacco products. HTPs were introduced into the market in 1988, though they were not a commercial success. The global decline in tobacco consumption may be one reason the industry has invented and marketed new products such as HTPs. The

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Also variously known as a partially combustion heat-not-burn product, heat-not-burn device, heat-not-burn tobacco product (HNB), Heat-not-Burn tobacco product, heat-not-burn cigarette (HC), heat-not-burn cig, HNB tobacco product, HnB tobacco product, HNB product, HnB product, heat-not-burn tobacco

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released Ploom, which has been withdrawn from the US. The brand remained with Japan Tobacco and the product has been replaced with Ploom Tech, where an aerosol passes through a capsule of granulated tobacco leaves. The Ploom brand uses aluminum capsules called Vapodes, where tobacco can heat up to

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to develop alternative tobacco products, such as HTPs. There has been a global decline in tobacco consumption that, if continued, will negatively impact the tobacco industry's profits, which has forced the industry to invent and market new products like HTPs. The introduction of HTPs may also have

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There are three general types of heated tobacco products. One that immediately heats processed tobacco to generate aerosol, another that uses processed tobacco that is heated in (but not generate) an aerosol, and one where the processed tobacco gives flavour to the aerosol as the latter moves over

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The tobacco companies use heated tobacco products as part of their broader political and public relations activities to position them as 'partners' to address the tobacco epidemic rather than as the vectors that are causing it. This is a similar strategy previously used by the tobacco industry to

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are often ineffective for quitting smoking, pregnant women turn to alternatives such as HTPs. There is no information available on the potential impact of HTP emissions from mother to fetus as of 2018. The risk to the fetus from HTPs during pregnancy is hard to quantify ; although the risk to the

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In Germany, HTP use is not common and is generally more frequent among richer and educated smokers. Since its sale in Japan in 2014, HTP use has been high; A 2017 survey in Japan found that of those who used the IQOS within the last month, 20 per cent had never smoked before. The products did not

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The impact on the overall population is unclear. Studies on second-hand HTP emissions as of 2018 were diverse and largely affiliated with manufacturers. There is disagreement over the extent to which HTPs generate air emissions, and the emissions' composition. There is anticipated to be a reduced

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A 2018 Public Health England report found that "ompared with cigarettes, heated tobacco products are likely to expose users and bystanders to lower levels of particulate matter and harmful and potentially harmful compounds (HPHC). The extent of the reduction found varies between studies." It also

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HTPs use embedded or external heat sources, heated sealed chambers, or product-specific customized cigarettes. Whereas e-cigarettes are electronic devices that vaporize a liquid containing nicotine, HTPs usually use tobacco in leaf or some other solid form, although there are some hybrid products

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The tobacco industry claims that smokers will switch to HTPs; however, IQOS users are more likely to smoke and/or use e-cigarettes as well. Among those who have tried or intend to try IQOS, never-smokers equal or outnumber smokers. A review of PMI's research found that smokers did not understand

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in Japan each month based on the latest search estimates for September 2017. Moreover, forecasts relying on the historical trend suggest heat-not-burn searches would increase an additional 32% (95%CI: -4 to 79) during 2018, compared to current estimates for 2017 (January–September), with further

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conducted by PMI for the approval of the IQOS product by the US FDA. The advisory panel appointed by the US FDA reviewed Philip Morris International's application in January 2018. The FDA granted permission to PMI to sell IQOS in the US on 30 April 2019, which also requires the company to follow

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Since the constituents of HeatSticks may differ from combustible cigarettes, including flavourants and additives, it is plausible that the IQOS aerosol may contain substances not found in tobacco smoke. The emissions of the IQOS HeatSticks and the IQOS menthol mini-cigarettes contain about three

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E-cigarette emissions machine with heated tobacco products. The emissions of four heated tobacco products can be generated in parallel in an emissions experiment. The emissions generated are analyzed using appropriate analytical techniques, which allows a comparison of different applications and

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Since 2017, PMI has been promoting its IQOS product in Europe and Asia, where IQOS products are sold as an alternative to regular cigarettes. Outside of an IQOS retail shop in Canada, marketing included a display sign with the message, "Building a Smoke-Free Future". Philip Morris International

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The term "heat-not-burn" refers to tobacco heated (at ~350 °C) by an electrically powered element or carbon instead of being fully combusted (at ~800 °C). Terms used in marketing for cigarette-like products that "heat rather than burn" refer to them as "reduced risk" and "innovative".

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note the lax enforcement over HTPs have been exploited by the presence of "IQOS embassies" and "IQOS boutiques"—fancy concept stores where IQOS is promoted as a status symbol and free samples are given—and believe the most recognized tobacco control policies in Italy (i.e., price/tax increase,

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HTPs are designed to be similar to their combustible counterparts by replicating the oral inhalation and exhalation, taste, rapid systemic delivery of nicotine, hand-to-mouth feel and throat hit sensations (depending on the temperature) when smoking traditional cigarettes. HTPs aim for a niche

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The dual use of HTPs and combustible products is common. Trying an HTP was more frequent among adults below the age of 30 and regular traditional cigarette users. A 2015 online survey found that 6.6% of 8240 respondents had tried an HTP at least once. Research demonstrated that there is a high

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and contribute significantly to levels of toxic aldehydes emitted in e-cigarette aerosols, as demonstrated by the presence of carbon monoxide (CO), nitrogen oxides, soot or tars, and aldehydes in emissions. Gases, liquid, and solid particles are also found in the emissions; the solids in the

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There has been significant controversy surrounding the marketing and use of these products. The tobacco companies are using a series of claims in the marketing of HTPs. In both websites and statements to the media and investors, HTPs are presented as less harmful but not risk-free. In a few

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As of January 2018, the industry has been rapidly introducing new heated tobacco products. HTPs were first sold in Japan, and several brands have been marketed there since 2014. Since the introduction of HTP in Japan there has been a 32% drop in the sale of tobacco cigarettes.

4955:

England, Lucinda J.; Kim, Shin Y.; Tomar, Scott L; Ray, Cecily S; Gupta, Prakash C.; Eissenberg, Thomas; Cnattingius, Sven; Bernert, John T.; Tita, Alan Thevenet N.; Winn, Deborah M.; Djordjevic, Mirjana V.; Lambe, Mats; Stamilio, David; Chipato, Tsungai; Tolosa, Jorge E. (2010).

1095:, including volatile organic compounds at comparable levels to cigarette smoke, polycyclic aromatic hydrocarbons, and carbon monoxide. Each of these substances, on the basis of rigorous research of cigarette smoke, are known to result in significant harms to health. According to 672:

Nicotine is released from tobacco heated above 150 °C. The burning process, substances emitted and their levels vary at different temperatures: distillation—the process during which nicotine and aromas are transferred from tobacco to smoke—occurs below 300 °C;

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around 35 °C. The formation of toxic volatile organic compounds, including formaldehyde, acetaldehyde, and acrolein, have been reported in e-cigarette aerosols at similar temperatures as the IQOS; flavoring chemicals in e-cigarettes have been discovered to undergo

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on Toxicity noted that "ommittees were particularly concerned for young people, who do not smoke, starting to use these products, due to the potential for longer exposure over the remainder of their lives compared to adults and to possible differences in sensitivity."

1834:. The Justice Ministry in Israel agreed with the view of three voluntary organizations that the IQOS is a tobacco product, and that it should be regulated in the same manner as tobacco products. In Israel the IQOS is taxed at the same rate as traditional cigarettes. 530:

who has studied IQOS, said that tobacco companies like PMI would have a "mega database" of Americans' smoking habits, and possibly "reprogram the current puffing delivery pattern of the IQOS to one that may be more reinforcing and with a higher addiction potential".

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2 is marketed by Shenzhen Yukan Technology Co., Limited, of China. The HTP can use any pack of 20 cigarettes on a single battery charge and does not use tobacco-filled cartridges. It is an updated version over the original IUOC and was formally launched in 2018 at

1219:

In December 2017, PMI launched TEEPS in the Dominican Republic. It is an HTP that looks similar to a traditional cigarette. Instead of an electrically controlled heating system, it uses a carbon heat source that, once lit, passes heat to a processed tobacco plug.

1123:

The iSmoke OneHitter by iSmoke can be used as a loose-leaf tobacco vaporizer or for use with waxy oils. It is described as a "heat, not burn" tobacco vaporizer, and was launched in 2015. It has a chamber that can be filled with up to 800 milligrams of tobacco.

968:, and is more compact than the original Firefly vaporizer. It uses a patented heating technology that heats the device up to the desired temperature (between 200 and 500 °F) with each puff rather than a preset temperature setting from the beginning. 620:. Affected rats exhibited significant pancreatic dysfunction and glucose intolerance. Other animal studies have reported insulin resistance in adult offspring due to maternal nicotine exposure; in animal models, nicotine has also been shown to activate 440:

Physiological changes in response to heated tobacco emissions, such as multiple organ system inflammation, energy metabolism, and carcinogenesis, have not been well characterised due to limited research in this area, especially in animal models. A 2018

250:. The two most common designs are those that use an electric battery to heat tobacco leaf (e.g., IQOS, glo, Pax) and those that use a carbon ember that is lit and then heats the tobacco (e.g., Eclipse, REVO, TEEPS). There are similar devices that heat 519:; for example, the HTP known as IQOS acts more as a gateway to traditional cigarette use (20% of users) than as a means of quitting (11% of users), and is not anticipated to have a lowered risk among dual users who make up the remaining 69%. In 2016 1153:

on 20 November 2017. According to the company, a two-hour battery charge lasts for up to 20 cigarette sticks, its refills are cheaper than the IQOS and glo, and will fit in the IQOS product, though they do not recommend doing so for safety reasons.

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The physical effects on users are not yet known. The emissions of IQOS are considered to be smoke by independent researchers, and were called smoke by Phillip Morris researchers until 2016. The emissions generated by IQOS contain the identical

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Jeong, Won Tae; Cho, Hyun Ki; Lee, Hyung Ryeol; Song, Ki Hoon; Lim, Heung Bin (2019). "Comparison of the content of tobacco alkaloids and tobacco-specific nitrosamines in 'heat-not-burn' tobacco products before and after aerosol generation".

1849:, which are regulated differently than traditional cigarettes for tax reasons. As a result, IQOS are taxed at a lower rate when compared to the 75% incurred on normal cigarettes. Emerging tobacco products are banned in Singapore by the 1062:

brands. Although it is marketed as a novel product, it is very similar to the Accord released by the same company in 1998; however, the IQOS sticks have more nicotine, more tar, and less tobacco. They are heated at a lower temperature.

491:. The nicotine content between HTP and traditional cigarette emissions are in similar ranges, which suggests a similar addictiveness and dependence potential. There is insufficient evidence on the efficacy of heated tobacco products on 322:

The different types of available HTPs vary in effect, creating a challenge for researchers. It is unknown how users evaluate product safety—one study found that about half of people believed they are safer than traditional cigarettes.

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in the mainstream aerosol of a heated tobacco product compared to the mainstream smoke of traditional cigarettes. The highest and lowest values in two different types of tobacco sticks and traditional cigarettes were given by Mallock

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strict marketing restrictions. IQOS formally launched in the US in October 2019. On 7 July 2020, the US FDA announced its ruling 456, which granted an "exposure modification" order that allows PMI to market IQOS in the United States.

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stated in 2016 that "unless and until independent evidence shows that IQOS and similar products are substantially less harmful than smoking then these products should be regulated in the same way as other tobacco products." In 2017,

6754:, Cao, Yinghui; Wang, Tao & Wang, Songfeng et al., "Integrally formed heat-not-burn smoking product and preparation method therefor", published 2019-09-26, assigned to Yunnan Xike Technology Co. Ltd. 1837:

Ploom, IQOS, and glo fall under the Tobacco Business Act as tobacco products in Japan because they consist of tobacco leaf. Ploom and IQOS are governed by the Tobacco Industries Act regulations as tobacco products in Japan. The

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between combustible tobacco smoking and e-cigarettes that aerosolise nicotine. There are different types of HTPs in the marketplace: some use tobacco sticks like glo and IQOS, while others use loose-leaf tobacco such as Pax and

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The IQOS consists of a charger around the size of a mobile phone and a pen-like holder. The disposable tobacco stick, also known as a HeatStick, is described as a mini-cigarette. The sticks contain processed tobacco soaked in

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in the UK stated in 2016 that due to "the tobacco industry's long record of deceit" regarding the health risks involving smoking, it is important to conduct independent studies into the health effects of tobacco products.

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HTP demand presents a host of tobacco control challenges similar to e-cigarettes and new challenges specific to these products. They have been advertised as reduced-risk tobacco products in their Japanese test market.

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with a heating blade, and was launched by Shenzhen ESON Technology Co. Ltd. ("ESON") in Dec. 2021 after PODA. NEAFS tobacco-free sticks does not use tobacco, but instead a nicotine infused, tea-based organic compound.

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Users experience blood nicotine levels that peak after six to seven minutes for both HTPs and traditional cigarettes. The IQOS produces slightly less blood nicotine overall than a traditional cigarette, but more than

6916:"Study Profile: The Japan "Society and New Tobacco" Internet Survey (JASTIS): A longitudinal internet cohort study of heat-not-burn tobacco products, electronic cigarettes and conventional tobacco products in Japan" 984:

with a tobacco stick that heats up to 240 °C. glo produces approximately 50% less nicotine emissions than IQOS. In May 2017 British American Tobacco released i-glo in Canada. Bonnie Herzog, a senior analyst at

935:

Heated tobacco product. a) Charger (left) and holder (right), b) Tobacco stick (left) and holder with tobacco stick inserted (right), c) Disassembled holder, with heating element visible (left) and the holder's lid

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debuted the Mok in Korea. According to the company, Mok is more compact and weighs less than other products such as glo, IQOS, and lil. The Coo sticks are longer and wider than tobacco sticks from other companies.

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Marynak, Kristy L.; Wang, Teresa W.; King, Brian A.; Agaku, Israel T.; Reimels, Elizabeth A.; Graffunder, Corinne M. (2018). "Awareness and Ever Use of "Heat-Not-Burn" Tobacco Products Among U.S. Adults, 2017".

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lead to underdevelopment and functional disorders later in life. Animal research in regards to maternal nicotine exposure on rats showed a direct adverse impact on pancreas development by reducing endocrine

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Kopa, Paulina Natalia; Pawliczak, Rafał (2019). "IQOS – a heat-not-burn (HnB) tobacco product – chemical composition and possible impact on oxidative stress and inflammatory response. A Systematic Review".

571:, for instance, deliver nicotine in a slow, stable manner, which is less addictive. Inhaled nicotine enters the blood quicker than oral consumption, and blood nicotine levels halve every one to two hours. 5459:, Sebastian, Andries Don; Conner, Billy Tyrone & Banerjee, Chandra K. et al., "Segmented smoking article with foamed insulation material", published 2016-11-08, assigned to 4355: 912:

The global decline of cigarette consumption and decrease in adult smoking prevalence (from 24% in 2007 to 21% in 2015), combined with the success of tobacco control, including the implementation of the

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Mallock, Nadja; Böss, Lisa; Burk, Robert; Danziger, Martin; Welsch, Tanja; Hahn, Harald; Trieu, Hai-Linh; Hahn, Jürgen; Pieper, Elke; Henkler-Stephani, Frank; Hutzler, Christoph; Luch, Andreas (2018).

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translate into the product being safer, even though PMI stated that the IQOS is safer than traditional cigarettes, as 58 substances in IQOS aerosols were found at lower levels than in cigarette smoke.

1633:. The above figure shows the Relative Search Volume (scaled from 0–100 and adjusted for number of total Google search volumes per month in Japan and the USA) for heat-not-burn and e-cigarette products. 1608:: 746–3,574) during 2015–2016, and they continued to grow an additional 100% (95% CI: 60–173) between 2016 and 2017; in practical terms, there are now between 5.9 and 7.5 million heat-not-burn related 498:

A 2018 World Health Organization report states that "onclusions cannot yet be drawn about their ability to assist with quitting smoking (cessation), their potential to attract new youth tobacco users (

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The share of the market in South Korea for heated tobacco products has surged at least five-fold during the last two years leading up to 2019. As of early 2018, these products are not sold in France.

893:. The Accord and Heatbar are predecessors of Philip Morris International's current HTPs. HTPs were not a commercial success, and most of them were quickly taken off the market following their debut. 874:

to endorse it. The Surgeon General did not reply to Podraza's letter. Few people used the Accord, and most of them also continued to use traditional cigarettes. The Accord ceased production in 2006.

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Ho, Sai Yin; Chen, Jianjiu; Leung, Lok Tung; Mok, Hoi Yan; Wang, Lijun; Wang, Man Ping; Lam, Tai Hing (2019). "Adolescent Smoking in Hong Kong: Prevalence, Psychosocial Correlates, and Prevention".

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Tabuchi, Takahiro; Kiyohara, Kosuke; Hoshino, Takahiro; Bekki, Kanae; Inaba, Yohei; Kunugita, Naoki (2016). "Awareness and use of electronic cigarettes and heat-not-burn tobacco products in Japan".

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latest generation of heated tobacco products may be an industry attempt to appeal with governments and health advocates by presenting a potential (but unproven) "harm reduction" product. Current

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Sales expanded throughout Japan in 2017. Japan Tobacco intended to spend $ 500 million to increase their heated tobacco manufacturing capacity by late 2018. Studies have not been conducted on

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launched a battery-powered heated product called glo in Japan before selling it in South Korea, Switzerland, Russia, and Ukraine. In France, glo uses tobacco sticks called Neostiks. It uses a

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report includes evidence that indicates HTPs may be safer than traditional cigarettes, but less safe than e-cigarettes. Some HTP aerosols studied were found to contain levels of nicotine and

2065: 870:-size product was marketed as "low-smoke". An attempt was made in 2007 by Kenneth Podraza, the Vice President of Research and Development at Philip Morris in the US at the time, to get the 515:

overlap between HTP users and female smokers. According to four epidemiological papers, 10–45 per cent of non-smokers use these products, and show the effectiveness of the marketing of the

428:, and suggests that HTPs generate less concentrations of airborne contaminants in indoor places in comparison to a traditional cigarette, though their use still reduces indoor air quality. 535:

people who experimented with the IQOS and 51 per cent who were interested in the product had never smoked before. Therefore, such a product may represent, at least in Italy, a gateway for

1985: 1096: 7515: 677:

occurs around 300 °C–700 °C and involves the decomposition of biopolymers, proteins, and other organic materials and generates the majority of substances emitted in smoke; and

526:

IQOS can record the user's smoking habits. While Philip Morris International stated it only retrieves the data when the product is not working properly, Gregory Connolly, a professor at

507:

over the potential for non-smokers including children and young people, who would not otherwise start to smoke cigarettes, to take up using these products as they are not without risk."

6327: 5416: 3303: 1914: 1647: 1667:. "The tobacco industry has opened heated tobacco product flagship stores, cafes and sponsored public events such as concerts and car races around the world, which is alarming," said 1818:, though the directive may apply to advertising for the IQOS' tobacco stick. The UK government has been looking into creating a separate category for taxing heated tobacco products. 1580:, which has an estimated global user count of 20 million. As of 2018, the IQOS is the most popular product, and was authorised for marketing by the FDA in the US on 30 April 2019. 547:

satisfy 86 per cent of users, and they did not quit using traditional cigarettes; they used both. HTP use among youth is unknown, but monitoring is underway as of March 2019.

7497: 7455: 1576:

As of 2017, HTPs are being introduced in markets around the world, and since October 2019, they have been sold in at least 49 countries. They are not as globally popular as the

1192:

180 °C. Because the Ploom Tech heats up more, it may generate more harmful emissions. In January 2019, Japan Tobacco introduced Ploom TECH+ and Ploom S in Tokyo, Japan.

1652: 7737: 3249:

Pacitto, A.; Stabile, L.; Scungio, M.; Rizza, V.; Buonanno, G. (2018). "Characterization of airborne particles emitted by an electrically heated tobacco smoking system".

5380: 5849: 6653: 3440: 624:(nAChRs) in the brain, which regulate brain development. Nicotine exposure during the first trimester of pregnancy (2 mg/kg/d) leads to structural changes in the 6306: 5687: 523:(PMI) acknowledged that IQOS is probably as addictive as tobacco smoking. IQOS is sold with a warning that states the best option is to avoid tobacco use altogether. 285:

indicates that toxic exposure from these products is greater than that of e-cigarettes. Smokers have reported HTP use to be less satisfying than smoking a cigarette.

1263:

respectively. Column 5 shows the reduction of the analytes in the mainstream aerosol of the heated tobacco product compared to traditional cigarettes by percentage.

6608: 7578: 7424: 8257: 319:

are. As of 2019, a limited number of independent studies have been conducted on HTPs, and further research will likely increase understanding of health effects.

4363: 338:, and compelling independent research was unavailable to support these claims. It also noted evidence that HTPs may be as dangerous as traditional cigarettes. 1940: 424:

and formaldehyde air levels when HTPs were used indoors. Another 2017 study discovered HTPs generated emissions of metal particulates, organic compounds, and

5757: 5579: 4609:"Heat-not-burn tobacco product use in Japan: its prevalence, predictors and perceived symptoms from exposure to secondhand heat-not-burn tobacco aerosol" 800:

As early as the 1960s, the tobacco companies developed alternative tobacco products to supplement the cigarette market. The first commercial HTP was the

5479: 612:

size and number, which was accompanied by a decrease in gene expression of specific transcription factors and blood glucose regulating hormones such as

281:. There is insufficient evidence on the effectiveness of HTPs on quitting smoking, or possible effects of second-hand exposure. The limited evidence on 8185: 6701: 354:

report states that HTPs may be much safer than traditional cigarettes but less safe than e-cigarettes. In a 2017 non-technical summary written by the

1786: 7241: 7679: 6087:

Drope, Jeffrey; Cahn, Zachary; Kennedy, Rosemary; Liber, Alex C.; Stoklosa, Michal; Henson, Rosemarie; Douglas, Clifford E.; Drope, Jacqui (2017).

7476: 5819: 463:

classes in HTP-exposed mice when compared with their counterparts that were exposed to cigarette smoke. It also discovered that even with reduced

8082: 371: 1951: 909:

beginning around 2007 after independent companies introduced them before major multinational tobacco companies entered the e-cigarettes market.

243: 5834: 698:

emissions have been called nicotine-free dry particulate matter rather than tar in papers written by people connected to the tobacco industry.

282: 5889: 945: 230:

to be inhaled from the tobacco, which contains nicotine and other chemicals. HTPs may also contain additives not found in tobacco, including

5870: 5782: 5556: 1846: 5602: 1663:

Companies employ similar strategies previously used for traditional cigarettes, such as marketing through a variety of outlets, including

8247: 914: 5514: 993:

by British American Tobacco in 2016 would let them catch up with the competition. glo is marketed as being easier to operate than IQOS.

749:

the former. HTPs heat tobacco leaves at a lower temperature than traditional cigarettes. Another type of HTP is the loose-leaf tobacco

4864: by Xiaoqiu Liu, Alessandra Lugo, Lorenzo Spizzichino, Takahiro Tabuchi, Giuseppe Gorini, and Silvano Gallus available under the 6877: 6273: 5728: 7968: 7776: 5535: 1106:. In March 2017, PMI submitted a premarket tobacco product application regarding its IQOS product to the US FDA. In December 2017, 812:

launched in 1988 and described as difficult to use. Many smokers disliked the taste, and it was not popular with users when it was

729: 7255:

Levy, David T.; Cummings, K. Michael; Villanti, Andrea C.; Niaura, Ray; Abrams, David B.; Fong, Geoffrey T.; Borland, Ron (2017).

6479: 5499: 5632: 2379:"Levels of selected analytes in the emissions of "heat not burn" tobacco products that are relevant to assess human health risks" 1604:

in Japan for "heat-not-burn products" (a marketing name for HTPs) increased substantially; average monthly searches rose 1,426% (

56: 4359: 2500:"Mechanisms of toxicity and biomarkers of flavoring and flavor enhancing chemicals in emerging tobacco and non-tobacco products" 889:

them. The Heatbar did not obtain any significant user reception, and was discontinued after the only benefit found was to lower

339: 5240: 2852:"New Tobacco and Tobacco-Related Products: Early Detection of Product Development, Marketing Strategies, and Consumer Interest" 2768:"Reynolds' decision to stop marketing of heated cigarette Revo illustrates challenges in selling adult smokers on new products" 1150: 7189:

Mathers, Annalise; Schwartz, Robert; O'Connor, Shawn; Fung, Michael; Diemert, Lori (2018). "Marketing IQOS in a dark market".

6675: 6441: 4514:"Light and mild redux: heated tobacco products' reduced exposure claims are likely to be misunderstood as reduced risk claims" 8180: 7556: 5363: 3545:"An online survey of users of tobacco vaporizers, reasons and modes of utilization, perceived advantages and perceived risks" 3424: 855:

also introduced a brand called Revo and stated that it was a "repositioning" of the Eclipse. The Revo was withdrawn in 2015.

350:

devices available in the UK, it is unclear if HTPs offer any favorable benefit as a plausible harm reduction product. A 2018

1778:

attempts to influence regulatory policy to sustain and increase their clientele in the midst of decreasing cigarette usage.

964:

The Firefly developed the Firefly 2, which heats loose-leaf plant material and concentrates and is often used to aerosolise

8369: 7804: 6972: 1571: 871: 5297:""And they told two friends...and so on": RJ Reynolds' viral marketing of Eclipse and its potential to mislead the public" 273:

comparable to conventional cigarettes. Although heated tobacco products may be less dangerous than cigarette smoking, the

8280: 8232: 2270: 1802:, wrote: "There is concern that heat-not-burn tobacco will skirt local ordinances that prevent smoking in public areas." 1092: 6089:"Key issues surrounding the health impacts of electronic nicotine delivery systems (ENDS) and other sources of nicotine" 5667: 3304:"How are Non-Combusted Cigarettes, Sometimes Called Heat-Not-Burn Products, Different from E-Cigarettes and Cigarettes?" 3112:

Lindson-Hawley, Nicola; Hartmann-Boyce, Jamie; Fanshawe, Thomas R; Begh, Rachna; Farley, Amanda; Lancaster, Tim (2016).

301: 8379: 8237: 6814:"They're heating up: Internet search query trends reveal significant public interest in heat-not-burn tobacco products" 6593: 6521: 6014: 5204: 3700: 3871:"Heat or Burn? Impacts of Intrauterine Tobacco Smoke and E-Cigarette Vapor Exposure on the Offspring's Health Outcome" 3799:

Caputi, TL (24 August 2016). "Industry watch: heat-not-burn tobacco products are about to reach their boiling point".

234:. HTPs generally heat tobacco to temperatures under 600 °C (1100 °F), a lower temperature than conventional 8036: 8011: 5742: 5073: 2354: 1898: 1042: 191: 173: 70: 6381: 8359: 8222: 4806:

Liu, Xiaoqiu; Lugo, Alessandra; Spizzichino, Lorenzo; Tabuchi, Takahiro; Gorini, Giuseppe; Gallus, Silvano (2018).

2709:"Electronic Cigarettes and Youth in the United States: A Call to Action (at the Local, National and Global Levels)" 1936: 1861: 1857: 1839: 1799: 816:

in Arizona and Missouri. It was shaped like a traditional cigarette, and required combustion to move the smoldered

621: 503: 451:

cultures when exposed to such emissions. A 2016 animal study showed that heated tobacco emissions did not increase

5767: 4587: 8087: 7978: 7899: 4607:

Tabuchi, Takahiro; Gallus, Silvano; Shinozaki, Tomohiro; Nakaya, Tomoki; Kunugita, Naoki; Colwell, Brian (2018).

926: 432:

noted that the evidence indicates that less nicotine was inhaled from HTPs than cigarette smoke, and exposure to

140: 6287:

Lasseter, Tom; Bansal, Paritosh; Wilson, Thomas; Miyazaki, Ami; Wilson, Duff; Kalra, Aditya (20 December 2017).

4031: 2693: 567:

Sharper peaks in blood nicotine levels from inhalation cause greater nicotine dependence than oral consumption.

8333: 7665: 5920:

Auer, Reto; Concha-Lozano, Nicolas; Jacot-Sadowski, Isabelle; Cornuz, Jacques; Berthet, Aurélie (1 July 2017).

5646: 3600: 3355:"A review of the impacts of tobacco heating system on indoor air quality versus conventional pollution sources" 1850: 1050:) is a non-combustible "reduced risk" smoking alternative that was introduced in June 2014 and is marketed by 805: 247: 17: 7718: 7312:

Liber, Alex C. (2018). "Heated tobacco products and combusted cigarettes: comparing global prices and taxes".

6464: 5398: 4187: 3461: 8374: 8160: 5797: 4766: 1103: 750: 6559: 6288: 4861: 3620:"E-cigarettes/electronic nicotine delivery systems: a word of caution on health and new product development" 8175: 8109: 7257:"A framework for evaluating the public health impact of e-cigarettes and other vaporized nicotine products" 6880: by Theodore L. Caputi, Eric Leas, Mark Dredze, Joanna E. Cohen, and John W. Ayers available under the 5434: 4781: 1790: 1782: 837: 833: 584: 568: 502:), or the interaction in dual use with other conventional tobacco products and e-cigarettes." In 2017, the 2910: by Yvonne CM Staal, Suzanne van de Nobelen, Anne Havermans, and Reinskje Talhout available under the 8165: 6751: 6578: 5854: 5480:"Philip Morris tries smokeless Accord: tobacco marketer, cautious about brand, doing 'consumer research'" 1831: 1540:

Tobacco stick, i.e. for heated tobacco products: a tobacco stick; for traditional cigarette: a cigarette.

1196: 1051: 878: 790: 711: 520: 105: 62: 7644: 6626: 644:

Tobacco stick; above, disassembled, below, intact. A: Reconstituted tobacco film, made of dried tobacco

8170: 7002: 6328:"FDA permits sale of IQOS Tobacco Heating System through premarket tobacco product application pathway" 5460: 4227:"E-cigarettes or heat-not-burn tobacco products — advantages or disadvantages for the lungs of smokers" 4110:"Heated tobacco products: another tobacco industry global strategy to slow progress in tobacco control" 3441:"Philip Morris' Smokeless Tobacco Stick Shouldn't Be Marketed As Safer Than Cigarettes, FDA Panel Says" 1952:"Further development of the partial guidelines for implementation of Articles 9 and 10 of the WHO FCTC" 1815: 6344: 5456: 1958: 8364: 8285: 8137: 7998: 6405: 5713: 3704: 1905: 1765:

pointing that harm reduction is achieved through tobacco control policies that decrease consumption.

1761:

promote itself as a partner of public health in reducing the harms of tobacco, while obfuscating the

1102:

In 2016, PMI submitted a multi-million page application to the US FDA for IQOS to be authorized as a

832:. In 1989, after spending $ 325 million, R. J. Reynolds pulled the Premier from the market after the 753:

that involves putting loose-leaf tobacco into a chamber that is electrically heated with an element.

385: 327: 258: 96: 7704: 7516:"Tax hike on heat-not-burn tobacco products under consideration as LDP begins review of tax reforms" 6812:

Shi, Yuyan; Caputi, Theodore L.; Leas, Eric; Dredze, Mark; Cohen, Joanna E.; Ayers, John W. (2017).

3094: by Gideon St.Helen, Peyton Jacob III, Natalie Nardone, and Neal L Benowitz available under the 8354: 8323: 8275: 7797: 7060: 6914:

Tabuchi, Takahiro; Shinozaki, Tomohiro; Kunugita, Naoki; Nakamura, Masakazu; Tsuji, Ichiro (2018).

5899: 5185: 3488:"Expanding clinical laboratory tobacco product evaluation methods to loose-leaf tobacco vaporizers" 3444: 1845:

Electronic tobacco products using dry material are regulated as e-cigarettes in South Korea by the

977: 335: 6540: 6363: 401: 8212: 8207: 5129:"Invisible smoke: third-party endorsement and the resurrection of heat-not-burn tobacco products" 2674: by Elke Pieper, Nadja Mallock, Frank Henkler-Stephani, and Andreas Luch available under the 527: 7534: 3486:

Lopez, Alexa A.; Hiler, Marzena; Maloney, Sarah; Eissenberg, Thomas; Breland, Alison B. (2016).

2671: 101: 8290: 8252: 8127: 8051: 3466: 2357: by Erikas Simonavicius, Ann McNeill1, Lion Shahab, and Leonie S Brose available under the 1059: 986: 706:

found in traditional cigarette emissions. The IQOS HeatSticks do not generate a flame, but are

645: 468: 331: 262: 144: 4163: 2163:

Belushkin, M.; Esposito, M.; Jaccard, G.; Jeannet, C.; Korneliou, A.; Tafin Djoko, D. (2018).

2066:"Philip Morris says it doesn't want you to buy its cigarettes, but will IQOS help it survive?" 1149:

The lil is an HTP that heats a cigarette stick with a circular blade that was launched by the

231: 7691: 5353: 4038: 3414: 3091: 2772: 1930:"Regulatory Impact Statement: Regulation of smokeless tobacco and nicotine-delivery products" 1921: 738: 703: 694: 397: 355: 351: 274: 266: 7133: 5557:"Why Philip Morris International's New Heated Products Will Do Better Than Its Last Attempt" 3960: 1691:

Product appeal and marketing terms used for online advertisement of heated tobacco products

722:

elements. This film consists of about 70% tobacco, as well as humectants (such as water and

8328: 8295: 8099: 7940: 7847: 7055: 6825: 5999: 5013:

Forster, Mark; Liu, Chuan; Duke, Martin G; McAdam, Kevin G; Proctor, Christopher J (2015).

3366: 1853:. China plans to pass legislation to ban the sale of these products to minors, as of 2019. 1630: 1577: 1055: 906: 847:

in the mid-1990s, which was available in limited distribution as of 2015, and promoted via

629: 347: 31: 7680:"New Zealand's legal action against IQOS postponed, consultation with Big Tobacco follows" 7137: 7128: 6881: 6872: 6716: 6423: 4865: 4856: 4167: 4158: 4032:"Toxicological evaluation of novel heat-not-burn tobacco products – non-technical summary" 3961:"Vaping Startup Pax Labs Raises $ 420 Million in Funding: Term Sheet for Monday, April 22" 3930: 3921: 3604: 3595: 3095: 3086: 2911: 2902: 2675: 2666: 2620:["Heat not burn" tobacco devices as new tobacco industry products: health risks]. 2358: 2349: 1593:

leaders predicted that HTPs may displace traditional cigarette smoking and, by extension,

1099:, IQOS is "harmful to health, but probably less harmful than smoking tobacco cigarettes". 155: 8: 8313: 8016: 7832: 7790: 3733:

St.Helen, Gideon; Jacob III, Peyton; Nardone, Natalie; Benowitz, Neal L (November 2018).

1977: 1773:

HTPs are subject to different regulations than traditional cigarettes. For example, some

1762: 1752:

The tobacco industry's use of the "harm reduction" framework also serves to fracture the

844: 801: 742: 572: 499: 6829: 4923: 3370: 2436:"A critical appraisal of the harm reduction argument for heat-not-burn tobacco products" 2009:"Cytotoxic effects of heated tobacco products (HTP) on human bronchial epithelial cells" 1856:

After IQOS launched a marketing campaign in New Zealand in December 2016, the country's

1842:

will deliberate over increasing the tax rate for heated tobacco products in April 2018.

1563: 1110:

published documents and testimonies of former employees detailing irregularities in the

881:

launched the Heatbar, which was very similar to the Accord. It was around the size of a

583:

Pregnant women who wish to quit smoking but are unable to are left with few options. As

8132: 8021: 7827: 7625: 7460: 7400: 7383: 7367: 7345: 7325: 7289: 7256: 7222: 7202: 7112: 7079: 6948: 6915: 6856: 6813: 6249: 6216: 6183: 6126: 6066: 5954: 5921: 5651: 5329: 5296: 5209: 5161: 5144: 5128: 5109: 5089: 5049: 5014: 4990: 4957: 4932: 4907: 4840: 4807: 4701: 4641: 4624: 4608: 4546: 4529: 4513: 4419: 4402: 4386: 4385:

Simonavicius, Erikas; McNeill, Ann; Shahab, Lion; Brose, Leonie S. (1 September 2019).

4332: 4142: 4125: 4109: 3965: 3905: 3870: 3824: 3812: 3767: 3750: 3734: 3654: 3619: 3579: 3544: 3520: 3487: 3282: 3226: 3209: 3193: 3146: 3113: 3070: 3053: 3037: 2886: 2851: 2821: 2743: 2708: 2655: 2532: 2499: 2468: 2435: 2411: 2378: 2333: 2316: 2300: 2246: 2213: 2145: 2041: 2024: 2008: 1664: 1600:

Since the introduction of PMI's IQOS brand in select Japanese cities in November 2014,

536: 6987: 3379: 3354: 2850:

Staal, Yvonne CM; van de Nobelen, Suzanne; Havermans, Anne; Talhout, Reinskje (2018).

2007:

Leigh, Noel J; Tran, Phillip L; O’Connor, Richard J; Goniewicz, Maciej Lukasz (2018).

1860:

stated in 2017 that the refill sticks are not legal for sale in New Zealand under the

151: 8217: 8046: 7983: 7945: 7852: 7649: 7629: 7617: 7609: 7605: 7405: 7387: 7337: 7329: 7294: 7276: 7214: 7206: 7171: 7117: 7099: 7033: 7025: 6953: 6935: 6861: 6843: 6254: 6236: 6187: 6175: 6167: 6118: 6110: 6070: 6058: 6050: 5959: 5941: 5359: 5334: 5316: 5248: 5214: 5166: 5148: 5101: 5093: 5054: 5036: 4995: 4977: 4937: 4845: 4827: 4747: 4739: 4693: 4685: 4646: 4628: 4551: 4533: 4467: 4459: 4424: 4406: 4324: 4316: 4256: 4248: 4147: 4129: 3910: 3892: 3816: 3772: 3754: 3659: 3641: 3584: 3566: 3525: 3507: 3503: 3420: 3392: 3384: 3274: 3266: 3231: 3213: 3151: 3133: 3075: 3057: 3005: 2997: 2891: 2873: 2813: 2805: 2748: 2730: 2647: 2639: 2537: 2519: 2473: 2455: 2416: 2398: 2338: 2320: 2251: 2233: 2194: 2186: 2137: 2129: 2046: 2028: 852: 809: 665: 609: 492: 447:

study suggested a less harmful pathophysiological response in human organotypic oral

359: 278: 7477:"In Blow to Philip Morris, Israel to Tax iQOS E-cigarettes Like Ordinary Cigarettes" 7349: 7226: 7167: 7021: 6733: 6204:. Netherlands National Institute for Public Health and the Environment. 15 May 2018. 6130: 5937: 4705: 4455: 4336: 3828: 3286: 2825: 2659: 2149: 1827:

smoking bans, advertising bans, and health warnings) have been compromised by HTPs.

1814:

Advertisement for the IQOS product itself is not regulated under the European Union

8242: 8119: 8072: 8041: 8031: 7925: 7894: 7837: 7601: 7395: 7379: 7321: 7284: 7268: 7198: 7163: 7151: 7107: 7091: 7017: 6943: 6927: 6851: 6833: 6649: 6505: 6244: 6228: 6157: 6100: 6042: 5983: 5949: 5933: 5540: 5442: 5324: 5308: 5156: 5140: 5113: 5085: 5044: 5026: 4985: 4969: 4927: 4919: 4835: 4819: 4731: 4677: 4636: 4620: 4541: 4525: 4451: 4414: 4398: 4308: 4238: 4137: 4121: 3900: 3882: 3808: 3762: 3746: 3649: 3631: 3574: 3556: 3515: 3499: 3374: 3353:

Kaunelienė, Violeta; Meišutovič-Akhtarieva, Marija; Martuzevičius, Dainius (2018).

3258: 3221: 3205: 3141: 3129: 3125: 3065: 3049: 2987: 2881: 2863: 2797: 2738: 2720: 2629: 2527: 2511: 2463: 2447: 2406: 2390: 2328: 2312: 2241: 2225: 2176: 2119: 2108:"Heat-not-Burn Tobacco Products: Tobacco Industry Claims No Substitute for Science" 2036: 2020: 1795: 1590: 1567:

Rapid fall in cigarette sales associated with the rise of HTP sales in Japan: from

1542:

All values were generated using the Health Canada Intense (HCI) puffing conditions.

1084: 1019: 901: 604: 516: 6046: 4588:"Statement on the toxicological evaluation of novel heat-not-burn tobacco product" 2801: 8227: 8067: 8026: 7988: 7955: 6838: 6646:"Japan Tobacco plans to quadruple smokeless tobacco output capacity by 2018: CEO" 5894: 5762: 5560: 5015:"An experimental method to study emissions from heated tobacco between 100-200°C" 4681: 3929: by Gerard Li, Sonia Saad, Brian G. Oliver, and Hui Chen available under the 3262: 2515: 2070: 1803: 1753: 1594: 1238: 1208: 1079:

The IQOS 3 Multi was also launched, and is capable of multiple consecutive uses.

981: 965: 897: 890: 848: 686: 421: 396:

than regular cigarettes. Other traditional cigarette emission substances such as

311: 251: 3036:

St.Helen, Gideon; Jacob III, Peyton; Nardone, Natalie; Benowitz, Neal L (2018).

2181: 2164: 1679:"switching completely" and that IQOS users are not likely to switch completely. 8104: 7963: 7935: 7920: 2075: 1807: 1111: 990: 941: 931: 682: 597: 540: 316: 7080:"Informing iQOS Regulations in the United States: A Synthesis of What We Know" 6162: 6146:"[Systematic analysis of the scientific literature on heated tobacco]" 6145: 5820:"Altria launches Iqos tobacco device in US, and the timing couldn't be better" 5031: 4973: 4312: 3735:"IQOS: examination of Philip Morris International's claim of reduced exposure" 3561: 3038:"IQOS: examination of Philip Morris International's claim of reduced exposure" 2992: 2978:[Systematic analysis of the scientific literature on heated tobacco]. 2975: 2868: 2634: 2617: 2394: 656:) to encourage aerosol formation, binding agents, and aroma agents. B: Hollow 8348: 8006: 7889: 7613: 7391: 7333: 7280: 7210: 7103: 7095: 7029: 6939: 6847: 6734:"Cigoo launches entry-level herbal HNB products, 6 flavors now on the market" 6240: 6171: 6114: 6054: 5945: 5850:"Philip Morris Aims to Revive Japan Sales With Cheaper Heat-Not-Burn Tobacco" 5355:

Brand Failures: The Truth about the 100 Biggest Branding Mistakes of All Time

5320: 5270: 5252: 5218: 5152: 5097: 5040: 4981: 4890: 4831: 4780:

Lasseter, Tom; Wilson, Duff; Wilson, Thomas; Bansal, Paritosh (15 May 2018).

4743: 4689: 4632: 4537: 4463: 4410: 4320: 4252: 4133: 3896: 3758: 3645: 3570: 3511: 3416:

Brand Failures: The Truth about the 100 Biggest Branding Mistakes of All Time

3388: 3270: 3217: 3137: 3061: 3001: 2877: 2809: 2734: 2643: 2618:"Tabakerhitzer als neues Produkt der Tabakindustrie: Gesundheitliche Risiken" 2616:

Pieper, Elke; Mallock, Nadja; Henkler-Stephani, Frank; Luch, Andreas (2018).

2523: 2459: 2402: 2324: 2237: 2190: 2133: 2032: 1668: 1609: 1188: 1163: 859: 773: 640: 589: 7136: by Carla J. Berg, Yael Bar-Zeev, and Hagai Levine2 available under the 3926: 3636: 3352: 2725: 1724:

Similar sized package as traditional cigarette, white or light grey or gold

1683:

intends to convert its customers in Japan to using heated tobacco products.

392:

comparable to regular cigarettes; they have also been found to contain more

7621: 7409: 7341: 7298: 7218: 7175: 7121: 7037: 6957: 6931: 6865: 6500: 6427: 6258: 6179: 6122: 6062: 5963: 5729:"Here's Why the Worst Might Be Yet to Come for Philip Morris International" 5668:"Weed tech heats up with a new smart vaporizer from Apple, Microsoft alums" 5607: 5338: 5312: 5170: 5105: 5058: 4999: 4941: 4849: 4823: 4751: 4697: 4650: 4555: 4471: 4428: 4328: 4260: 4151: 3914: 3820: 3776: 3663: 3588: 3529: 3396: 3278: 3235: 3155: 3079: 3009: 2907: 2895: 2817: 2752: 2651: 2541: 2477: 2451: 2420: 2342: 2255: 2198: 2141: 2124: 2107: 2050: 1629:

Google searches for heat-not-burn tobacco (heated tobacco) outpace rise of

1548: 1245: 882: 561: 413: 405: 393: 7738:"New Zealand court gives Philip Morris nod to sell heated tobacco product" 7456:"Orgs slam Litzman for allowing sale of iQOS heated, smokeless cigarettes" 7003:"Perplexing Conclusions Concerning Heat-Not-Burn Tobacco Cigarettes—Reply" 6202:"Addictive nicotine and harmful substances also present in heated tobacco" 4243: 4226: 3887: 2299:

Simonavicius, Erikas; McNeill, Ann; Shahab, Lion; Brose, Leonie S (2018).

575:

causes deteriorating mood and creates a craving for nicotine consumption.

376:

Heated tobacco products expose the user and bystanders to an aerosol. The

83: 8143: 6683: 5871:"Philip Morris unveils new smokeless cigarettes in a bid to rev up sales" 4442:

Katz, Mitchell H. (July 2017). "No Smoke—Just Cancer-Causing Chemicals".

3192:

Elias, Jesse; Dutra, Lauren M; St. Helen, Gideon; Ling, Pamela M (2018).

1774: 1138: 843:

The Premier product concept was developed further and re-launched as the

813: 625: 417: 290: 7498:"Justice Ministry says iQOS product will be treated as ordinary tobacco" 6770: 6480:"Smoke Up: An Interview With The Creator Of The Ultracool Pax Vaporizer" 5515:"Revealed: tobacco giant's secret new weapon in the age of smoking bans" 3111: 2214:"Acute eosinophilic pneumonia following heat-not-burn cigarette smoking" 1957:. World Health Organization. 12 July 2016. pp. 1–11. Archived from 1781:

In the United States, these products fall under the jurisdiction of the

467:

in HTP emissions, overuse (40 tobacco sticks per day) can still lead to

214:

product that heats the tobacco at a lower temperature than conventional

6676:"Imperial Brands aims to convince smokers to switch to vaping products" 6560:"Want to microdose marijuana? This company is making it easier for you" 6484: 6289:"Scientists describe problems in Philip Morris e-cigarette experiments" 6105: 6088: 5381:"Is This The Cigarette Of The Future, And Will The FDA Let You Buy It?" 4512:

Popova, Lucy; Lempert, Lauren Kass; Glantz, Stanton A (November 2018).

2106:

Jenssen, Brian P.; Walley, Susan C.; McGrath-Morrow, Sharon A. (2017).

1913:

McNeill, A; Brose, LS; Calder, R; Bauld, L; Robson, D (February 2018).

1601: 1229:

patented plant particle as a carrier, added flavourants and additives.

886: 678: 649: 593: 456: 452: 448: 389: 270: 7272: 6382:"The iSmoke OneHitter, iSmoke "3-in-1" and iSmoke Oven join portfolio" 4958:"Non-cigarette tobacco use among women and adverse pregnancy outcomes" 4908:"Tobacco use disorder and treatment: New challenges and opportunities" 4735: 3348: 3346: 3344: 1009:

IQOS, consisting of a charger, a heater and a small tobacco cigarette.

7813: 6232: 5919: 5603:"Philip Morris's vision of cigarette-free future met with scepticism" 4765:

Mulier, Thomas; Chambers, Sam; Liefgreen, Liefgreen (24 March 2016).

3603: by Sébastien Queloz and Jean-François Etter available under the 2229: 674: 484: 235: 215: 7154:; Redberg, RF (6 November 2017). "Science Requires Open Discourse". 5688:"BAT finds strong Japan demand for its Glo smokeless tobacco device" 5074:"iQOS: evidence of pyrolysis and release of a toxicant from plastic" 5072:

Davis, Barbara; Williams, Monique; Talbot, Prue (20 February 2018).

1986:

Netherlands National Institute for Public Health and the Environment

1097:

Netherlands National Institute for Public Health and the Environment

766: 6702:"Philip Morris Plunges the Most in a Decade on Slump in Cigarettes" 6679: 6563: 5438: 5275: 4188:"'Heat-not-burn' cigarettes still release cancer-causing chemicals" 3341: 3107: 3105: 2849: 1176: 825: 817: 723: 707: 653: 617: 488: 464: 460: 443: 425: 409: 381: 219: 7867: 4166: by Stella A Bialous and Stanton A Glantz available under the 1915:"Evidence review of e-cigarettes and heated tobacco products 2018" 7930: 7915: 7884: 7481: 6973:"Burning Issues: The Global State of Tobacco Harm Reduction 2020" 6897:"Burning Issues: the Global State of Tobacco Harm Reduction 2020" 6750: 5835:"Philip Morris Sees $ 700 Million Boost From iQOS Smoking Device" 5695: 5519: 4889:

This article incorporates text from this source, which is in the

4301:

Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz

3194:"Revolution or redux? Assessing IQOS through a precursor product" 2622:

Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz

2615: 2275: 1605: 1251: 1107: 948:

but not as much nicotine compared with a tank-style e-cigarette.

829: 821: 661: 657: 613: 433: 377: 223: 211: 6913: 4387:"Heat-not-burn tobacco products: a systematic literature review" 4356:"ASH reaction to new Philip Morris IQOS 'heat not burn' product" 3732: 3102: 3035: 2301:"Heat-not-burn tobacco products: a systematic literature review" 1651:

Temporary smoking room and a sales promotion of glo at the 2016

7973: 7842: 7771: 7560: 7425:"Philip Morris International Bets Big On The Future Of Smoking" 7188: 6445: 6424:"KT&G launches e-cigarette brand to take on foreign rivals" 5979:"Will 2018 Be Philip Morris International Inc's Best Year Yet?" 5484: 2162: 1067: 885:

and was said to heat specially-designed cigarettes rather than

7577:. Ministry of Health (Singapore). 28 July 2016. Archived from 5576:"Has Philip Morris Learned from Heat-not-Burn Tobacco's Past?" 4384: 2976:"Le tabac chauffé : revue systématique de la littérature" 2969: 2967: 2965: 2963: 2961: 2959: 2957: 2955: 2953: 2951: 2949: 2947: 2945: 2943: 2941: 2298: 222:, which is a highly addictive chemical. The heat generates an 7857: 7782: 6541:"How two guys from Stanford built the 'iPhone of vaporizers'" 2939: 2937: 2935: 2933: 2931: 2929: 2927: 2925: 2923: 2921: 2271:"What Is a Heat-Not-Burn Cigarette and Can It Help You Quit?" 2212:

Kamada, Takahiro; Yamashita, Yosuke; Tomioka, Hiromi (2016).

2165:"Role of testing standards in smoke-free product assessments" 1071: 953: 867: 793:' Heatbar pictured without a specifically designed cigarette. 668:

mouthpiece, which mimics the feel of a traditional cigarette.

362:, even though it found HTPs to be less harmful than smoking. 227: 6286: 5633:"What you need to know about Heat-not-Burn (HNB) cigarettes" 5536:"Philip Morris Is Releasing A Bunch Of Crazy New Cigarettes" 4882:. Centers for Disease Control and Prevention. 11 March 2019. 4606: 334:

for HTPs compared with traditional cigarettes were based on

8094: 6609:"Japan Tobacco ratchets up smokeless war with new products" 5922:"Heat-Not-Burn Tobacco Cigarettes: Smoke by Any Other Name" 5874: 5672: 4782:"Philip Morris device knows a lot about your smoking habit" 4721: 3485: 3462:"Tobacco company charged over importing prohibited product" 2498:

Kaur, Gurjot; Muthumalage, Thivanka; Rahman, Irfan (2018).

2105: 1031: 1025: 1013: 7254: 6215:

Hendlin, Yogi Hale; Elias, Jesse; Ling, Pamela M. (2017).

4779: 3869:

Li, Gerard; Saad, Sonia; Oliver, Brian; Chen, Hui (2018).

3306:. United States Food and Drug Administration. 16 May 2019. 3248: 2918: 2006: 1867:

As of 2019, 49 countries have permitted the sale of IQOS.

1569:

Burning Issues: The Global State of Tobacco Harm Reduction

1005: 940:

HTPs use a heating system where the tobacco is heated and

784: 681:

occurs above 750 °C and results in the generation of

6522:"Pax 2 Vaporizer Review: It's Like Smoking In the Future" 6310: 5915: 5913: 5911: 5909: 5271:"Philip Morris could stop making conventional cigarettes" 5189: 4808:"Heat-Not-Burn Tobacco Products Are Getting Hot in Italy" 4805: 4593:. Committee on Toxicity. 11 December 2017. pp. 1–10. 4483: 4481: 4272: 4270: 3995: 3993: 3991: 3114:"Interventions to reduce harm from continued tobacco use" 2294: 2292: 2290: 2288: 2286: 772:

Steam Hot One, a Japanese variant of the Eclipse made by

420:

are also found in HTPs. A 2017 study found a 10% rise in

6144:

Dautzenberg, B.; Dautzenberg, M.-D. (11 November 2018).

6137: 4056: 4054: 4052: 4050: 4048: 2845: 2843: 2841: 2839: 2837: 2835: 1980:[Alternative tobacco products: harm reduction?] 1671:, director of the Asian Consultancy on Tobacco Control. 1246:

Comparison to mainstream smoke of traditional cigarettes

8258:

Protocol to Eliminate Illicit Trade in Tobacco Products

7435: 7242:"Big Tobacco Wants to Turn Japan's Smokers Into Vapers" 6442:"KT&G launches sales of new tobacco-heating device" 5798:"Why Philip Morris's iQOS Sales in Japan Are Promising" 4764: 3191: 3031: 3029: 3027: 3025: 3023: 3021: 3019: 2376: 1075: 702:

times the amount of water and about half the amount of

7719:"iQOS may not be as harm-free as claimed, study finds" 7686:(1465). New Zealand Medical Journal. 10 November 2017. 7557:"Why Is Korea Easier To Conquer For iQOS Than Europe?" 7078:

Berg, Carla J.; Bar-Zeev, Yael; Levine, Hagai (2020).

7001:

Auer, Reto; Cornuz, Jacques; Berthet, Aurélie (2017).

6274:"The FDA Moves Forward With Philip Morris iQOS Review" 6143: 5906: 5500:"Anti-smoking body attacks smokeless cigarette device" 4906:

Ziedonis, Douglas; Das, Smita; Larkin, Celine (2017).

4717: 4715: 4493: 4478: 4267: 3988: 2973: 2493: 2491: 2489: 2487: 2283: 2211: 714:

researchers stated their IQOS product produces smoke.

261:

report did not find any evidence to support claims of

7495: 7447: 6907: 6086: 5890:"Philip Morris unveils smoke-free cigarette in Korea" 5241:"Little Smoke, Little Tar, but Full Dose of Nicotine" 4103: 4101: 4099: 4097: 4095: 4093: 4091: 4089: 4045: 3329: 3319: 3317: 3315: 3313: 2832: 2611: 2609: 2607: 2605: 2603: 2601: 2599: 2597: 2595: 2593: 2591: 2589: 2587: 2585: 2583: 2581: 2579: 2577: 2575: 2573: 2571: 2497: 1211:

was developing a heated tobacco product named Pulze.

1043: 1034: 1028: 7182: 7073: 7071: 6896: 5264: 5262: 5012: 4666: 4602: 4600: 4567: 4565: 4203: 4201: 4087: 4085: 4083: 4081: 4079: 4077: 4075: 4073: 4071: 4069: 3942: 3940: 3716: 3714: 3016: 2569: 2567: 2565: 2563: 2561: 2559: 2557: 2555: 2553: 2551: 2156: 596:, and abnormal brain growth. Nicotine may result in 7748: 6811: 6217:"The Pharmaceuticalization of the Tobacco Industry" 5783:"5 Things Every Philip Morris Investor Should Know" 5290: 5288: 5286: 5071: 4712: 4511: 3978: 3976: 2484: 2101: 2099: 2097: 2095: 2093: 2091: 2089: 2087: 2085: 1022: 7077: 6417: 6415: 6025: 5601:Davies, Rob; Monaghan, Angela (30 November 2016). 5502:. Tobacco Journal International. 11 December 2007. 4954: 4662: 4660: 4293: 4291: 4289: 4287: 4285: 3701:"Heated tobacco products (HTPs) information sheet" 3310: 3242: 3187: 3185: 2205: 1830:HTPs are not restricted for sale in Israel by the 866:Japan, and renamed it Oasis. The battery-powered, 7474: 7248: 7068: 7000: 6807: 6805: 6803: 6801: 6799: 6797: 6795: 6793: 6791: 6307:"FDA Panel Gives Qualified Support To Claims For" 6208: 6082: 6080: 5848:Uranaka, Taiga; Ando, Ritsuko (22 October 2018). 5758:"Philip Morris Int'l to Sell Marlboro HeatSticks" 5743:"Innovation Drives BAT's $ 47 Billion Bid -- WSJ" 5259: 4905: 4597: 4562: 4198: 4066: 3937: 3711: 3481: 3479: 3477: 3183: 3181: 3179: 3177: 3175: 3173: 3171: 3169: 3167: 3165: 2700: 2548: 2372: 2370: 2368: 1899:"WHO Report on the Global Tobacco Epidemic, 2019" 1787:Family Smoking Prevention and Tobacco Control Act 293:may or may not apply to heated tobacco products. 8346: 7453: 7144: 6519: 6265: 6214: 5401:. Tobacco Journal International. 5 January 2015. 5283: 4880:"What Do We Know About Heated Tobacco Products?" 3973: 3868: 3543:Queloz, Sébastien; Etter, Jean-François (2019). 2082: 1133: 836:and other organizations recommended that the US 277:suggests that it would be better for smokers to 6994: 6714: 6421: 6412: 6015:"Philip Morris rolls out iQOS smokeless smokes" 4901: 4899: 4657: 4282: 4181: 4179: 4177: 3536: 3298: 3296: 2786: 1978:"Alternatieve tabaksproducten: harm reduction?" 1597:strategies typically framed around cigarettes. 1175:In 2010, the company Ploom (later rebranded as 1093:harmful constituents as tobacco cigarette smoke 997:and heats tobacco to approximately 35 °C. 372:Composition of heated tobacco product emissions 7591: 7550: 7548: 7368:"Heated tobacco products: the example of IQOS" 7361: 7359: 7049: 7047: 6788: 6695: 6693: 6644:Uranaka, Taiga; Sarkar, Himani (29 May 2017). 6594:"JT announces launch of next-generation Ploom" 6399: 6397: 6395: 6330:. Food and Drug Administration. 30 April 2019. 6077: 5833:Mulier, Thomas; Thesing, Gabi (26 June 2014). 5749: 5720: 5707: 5705: 5600: 5006: 4948: 4801: 4799: 4797: 4795: 4299:the German population (the DEBRA study)]. 3864: 3862: 3860: 3858: 3611: 3474: 3162: 2687: 2685: 2427: 2365: 1276:Traditional Cigarettes (Counts et al. 2005; ) 7798: 7657: 7575:"Singapore Enhances Tobacco Control Measures" 7526: 6979: 6643: 6585: 6532: 6280: 6031: 5832: 5813: 5811: 5809: 5807: 5626: 5624: 5622: 5620: 5618: 5417:"Reynolds ends Revo test market in Wisconsin" 5410: 5408: 5268: 5120: 4962:Acta Obstetricia et Gynecologica Scandinavica 4220: 4218: 4216: 4108:Bialous, Stella A; Glantz, Stanton A (2018). 4107: 3856: 3854: 3852: 3850: 3848: 3846: 3844: 3842: 3840: 3838: 3794: 3792: 3790: 3788: 3786: 2706: 1713:Clean (white, bright blue), stylish, elegant 905:been a response to the growing popularity of 7729: 6637: 6600: 6570: 5881: 5841: 5435:"Reynolds launching heat-not-burn cigarette" 5294: 4896: 4773: 4174: 3952: 3293: 2974:Dautzenberg, B.; Dautzenberg, M.-D. (2018). 2780: 2000: 840:(FDA) restrict it or classify it as a drug. 315:unclear as to what the short- and long-term 265:compared to conventional cigarettes. A 2018 8248:WHO Framework Convention on Tobacco Control 7585: 7554: 7545: 7356: 7150: 7053: 7044: 6708: 6690: 6551: 6392: 6339: 6337: 6322: 6320: 5991: 5970: 5862: 5847: 5702: 5639: 5578:. Euromonitor International. Archived from 5567: 5506: 5427: 5183: 4792: 4582: 4580: 4297: 3695: 3693: 3542: 3408: 3406: 2759: 2682: 2433: 915:WHO Framework Convention on Tobacco Control 71:Learn how and when to remove these messages 7805: 7791: 7305: 6513: 6459: 6457: 6455: 5826: 5804: 5755: 5615: 5405: 5372: 4758: 4350: 4348: 4346: 4213: 4026: 4024: 4022: 4020: 4018: 4016: 4014: 4012: 4010: 4008: 3835: 3783: 3691: 3689: 3687: 3685: 3683: 3681: 3679: 3677: 3675: 3673: 3617: 3456: 3454: 2707:Jenssen, Brian P.; Boykan, Rachel (2019). 1555:= nicotine-free dried particulate matter. 989:, stated that the proposed acquisition of 154:. Please do not remove this message until 8153: 7672: 7645:"Legality of tobacco product in question" 7567: 7399: 7288: 7111: 6947: 6855: 6837: 6361: 6355: 6271: 6248: 6194: 6161: 6104: 5953: 5780: 5726: 5659: 5328: 5160: 5126: 5065: 5048: 5030: 4989: 4931: 4839: 4640: 4545: 4418: 4242: 4141: 3904: 3886: 3766: 3653: 3635: 3618:Unger, Michael; Unger, Darian W. (2018). 3578: 3560: 3519: 3378: 3225: 3145: 3069: 2991: 2885: 2867: 2742: 2724: 2633: 2531: 2467: 2410: 2332: 2245: 2180: 2123: 2040: 1746:Packed as traditional cigarette, stylish 600:to the neurological growth of the fetus. 478: 459:and their metabolic enzymes, and several 192:Learn how and when to remove this message 174:Learn how and when to remove this message 7969:Cigarette smoking among college students 7711: 7666:"iQos heatsticks declared illegal in NZ" 7532: 6985: 6591: 6538: 6434: 6334: 6317: 6006: 5647:"10 Best Weed Vaporizers to Buy in 2019" 5573: 5345: 4577: 4435: 4185: 3958: 3403: 2694:"BAT to launch its HnB device in Russia" 2268: 1646: 1562: 1004: 930: 733:Tobacco film (right side) following use. 728: 639: 300: 150:Relevant discussion may be found on the 7735: 7663: 7454:Siegel-Itzkovich, Judy (2 March 2017). 7441: 6970: 6901:Global State of Tiobacco Harm Reduction 6606: 6498: 6452: 6299: 5887: 5711: 5680: 5512: 5477: 5358:. Kogan Page Publishers. pp. 51–. 5269:O'Connell, Dominic (30 November 2016). 5205:"'Smokeless' Cigarette's Hapless Start" 4872: 4670:American Journal of Preventive Medicine 4499: 4487: 4343: 4276: 4060: 4005: 3999: 3670: 3451: 3433: 3335: 3118:Cochrane Database of Systematic Reviews 2691: 2262: 2057: 1912: 1273:Tobacco sticks (Mallock et al. 2018; ) 1151:Korea Tobacco & Ginseng Corporation 896:In years leading up to 2018, increased 858:The Steam Hot One was sold in Japan by 664:film filter cools the aerosol. D: Soft 14: 8347: 7496:Judy Siegel-Itzkovich (3 April 2018). 7422: 7365: 6728: 6726: 6699: 6576: 6557: 6403: 6351:. Harbor Communications. 4 March 2015. 5997: 5976: 5868: 5817: 5795: 5630: 5554: 5414: 5378: 5203:McGill, Douglas C (19 November 1988). 5202: 5184:Parker-Pope, Tara (10 February 2001). 4224: 3798: 2765: 2169:Regulatory Toxicology and Pharmacology 556:take more puffs at shorter intervals. 7786: 7642: 7475:Ronny Linder-Ganz (16 January 2018). 7311: 6477: 5665: 5533: 5239:Hilts, Philip J. (27 November 1994). 5238: 5127:Elias, Jesse; Ling, Pamela M (2018). 2440:Revista Panamericana de Salud Pública 1939:. 2017. pp. 1–52. Archived from 959: 8319: 7754: 5869:LaVito, Angelica (22 October 2018). 5756:Felberbaum, Michael (26 June 2014). 5712:Caruana, Diane (25 September 2018). 5351: 4571: 4441: 4207: 3946: 3412: 3323: 2434:Paumgartten, Francisco J.R. (2018). 2063: 1976: 1928: 872:Surgeon General of the United States 242:that can use both solid tobacco and 124: 77: 36: 8233:Tobacco Master Settlement Agreement 7239: 6894: 6723: 6465:"New HNB Device from China Tobacco" 6422:Song Seung-hyun (7 November 2017). 6093:CA: A Cancer Journal for Clinicians 6012: 5818:LaVito, Angelica (4 October 2019). 5781:Caplinger, Dan (23 November 2015). 5574:MacGuill, Shane (23 January 2014). 5478:Pollack, Juddan (27 October 1997). 3982: 3720: 2856:JMIR Public Health and Surveillance 1950: 1897: 1182: 1118: 24: 8238:Tobacco packaging warning messages 7866: 7664:Caruana, Diane (3 February 2017). 7643:Elder, Vaughan (13 January 2017). 7535:"IQOS available in Seoul Saturday" 7384:10.1136/tobaccocontrol-2018-054601 7326:10.1136/tobaccocontrol-2018-054602 7203:10.1136/tobaccocontrol-2017-054216 6700:Kaplan, Jennifer (19 April 2018). 6607:Uranaka, Taiga (16 January 2019). 6592:Tuinstra, Taco (26 January 2016). 5766:. Associated Press. Archived from 5631:Harlay, Jérôme (9 November 2016). 5399:"New heat-not-burn brand from RAI" 5145:10.1136/tobaccocontrol-2018-054433 5090:10.1136/tobaccocontrol-2017-054104 4912:Dialogues in Clinical Neuroscience 4625:10.1136/tobaccocontrol-2017-053947 4530:10.1136/tobaccocontrol-2018-054324 4403:10.1136/tobaccocontrol-2018-054419 4362:. 30 November 2016. Archived from 4126:10.1136/tobaccocontrol-2018-054340 3959:Marinova, Polina (22 April 2019). 3813:10.1136/tobaccocontrol-2016-053264 3751:10.1136/tobaccocontrol-2018-054321 3210:10.1136/tobaccocontrol-2018-054327 3054:10.1136/tobaccocontrol-2018-054321 2692:Caruana, Diane (25 October 2017). 2317:10.1136/tobaccocontrol-2018-054419 2025:10.1136/tobaccocontrol-2018-054317 543:substitution for current smokers. 539:among never-smokers rather than a 455:lipids and proteins, inflammatory 283:air emissions from the use of HTPs 25: 8391: 8012:Cigarette smoking for weight loss 7764: 7736:Zaharia, Marius (27 March 2018). 7555:Trefis Team (13 September 2017). 7320:(6): tobaccocontrol–2018–054602. 7197:(2): tobaccocontrol–2017–054216. 6520:Adam Clark Estes (23 July 2015). 6035:Toxicology Mechanisms and Methods 5796:Nathan, Ralph (12 October 2016). 5513:Houston, Cameron (27 June 2007). 5295:Anderson, S J; Ling, P M (2008). 5084:(1): tobaccocontrol–2017–054104. 4924:10.31887/DCNS.2017.19.3/dziedonis 4041:. 11 December 2017. pp. 1–4. 3380:10.1016/j.chemosphere.2018.05.039 2766:Craver, Richard (2 August 2015). 2311:(5): tobaccocontrol–2018–054419. 1811:about them, should be regulated. 1710:Reduced risk product, innovative 1170: 622:nicotinic acetylcholine receptors 550: 504:Ministry of Health in New Zealand 296: 52:This article has multiple issues. 8318: 8309: 8308: 8286:Countries by tobacco consumption 8223:Smoking bans in private vehicles 7770: 7636: 7606:10.1016/j.jadohealth.2019.01.003 7508: 7489: 7468: 7416: 7233: 7132: This article incorporates 7127: 6964: 6888: 6876: This article incorporates 6871: 6763: 6744: 6668: 6619: 6579:"Blending nature and technology" 6577:Rossel, Stefanie (1 July 2016). 6492: 6471: 6406:"Heat-Not-Burn: Back to Tobacco" 6374: 6150:Revue des Maladies Respiratoires 5998:Rossel, Stefanie (1 June 2016). 5977:Duprey, Rich (9 December 2017). 5415:Craver, Richard (28 July 2015). 4884: 4860: This article incorporates 4855: 4231:Advances in Respiratory Medicine 4162: This article incorporates 4157: 3925: This article incorporates 3920: 3599: This article incorporates 3594: 3504:10.1016/j.drugalcdep.2016.10.005 3090: This article incorporates 3085: 2980:Revue des Maladies Respiratoires 2906: This article incorporates 2901: 2670: This article incorporates 2665: 2353: This article incorporates 2348: 1937:Ministry of Health (New Zealand) 1862:Smoke-free Environments Act 1990 1800:Los Angeles County Health Agency 1622: 1018: 824:containing more than 50 percent 783: 765: 129: 82: 41: 7979:Smoking in association football 7423:Fisher, Daniel (16 June 2014). 7168:10.1001/jamainternmed.2017.5763 7056:"New forms of smoking catch on" 7022:10.1001/jamainternmed.2017.5861 6715:Stefanie Rossel (1 June 2017). 6627:"JT to expand Ploom TECH sales" 6539:Stenovec, Tim (12 March 2016). 6404:Schmid, Thomas (6 March 2019). 5938:10.1001/jamainternmed.2017.1419 5789: 5774: 5735: 5594: 5555:Cooper, Ted (1 February 2014). 5548: 5527: 5492: 5471: 5449: 5391: 5232: 5196: 5186:""Safer" Cigarettes: A History" 5177: 4505: 4456:10.1001/jamainternmed.2017.1425 4378: 3726: 2064:Kary, Tiffany (18 April 2019). 1891: 1877: 927:List of heated tobacco products 635: 332:lowered risk or health benefits 263:lowered risk or health benefits 60:or discuss these issues on the 7812: 7533:Jae-hyuk, Park (26 May 2017). 7240:Yui, Monami (28 August 2016). 6558:Taylor, Chris (19 June 2018). 6499:Lavrinc, Damon (1 July 2013). 6448:News Agency. 11 November 2017. 6272:Caplinger, Dan (26 May 2017). 6013:Tai, Mariko (31 August 2015). 5727:Caplinger, Dan (31 May 2017). 5379:Fisher, Daniel (29 May 2014). 4186:Rapaport, Lisa (26 May 2017). 3130:10.1002/14651858.CD005231.pub3 1847:Ministry of Health and Welfare 1066:Initially launched in 2014 in 13: 1: 6752:WO application 2019179532 6047:10.1080/15376516.2019.1669245 5714:"BAT Launches Glo in Ukraine" 2802:10.1080/08958378.2019.1572840 1993: 1768: 1558: 1199:'s Ploom product as of 2017. 1104:modified risk tobacco product 585:nicotine replacement products 569:Nicotine replacement products 358:, it recommends that smokers 330:report stated that claims of 8110:Nicotine replacement therapy 7594:Journal of Adolescent Health 6839:10.1371/journal.pone.0185735 6478:Biggs, John (17 June 2012). 6467:. Tobacco Asia. 30 May 2019. 5888:Hyo-sik, Lee (17 May 2017). 5855:U.S. News & World Report 4682:10.1016/j.amepre.2018.04.031 3263:10.1016/j.envpol.2018.04.137 2516:10.1016/j.toxlet.2018.02.025 1908:. July 2019. pp. 1–209. 1791:Action on Smoking and Health 1783:Food and Drug Administration 1642: 838:Food and Drug Administration 834:American Medical Association 712:Phillip Morris International 578: 365: 340:Action on Smoking and Health 7: 8370:Products introduced in 2014 8281:Cigarette smoke carcinogens 7054:Jane Cheung (24 May 2019). 6775:NEAFS | Tobacco Free Sticks 6368:Convenience Store Decisions 6349:Convenience Store Decisions 6221:Annals of Internal Medicine 5666:Crist, Ry (20 April 2019). 5534:Lubin, Gus (25 June 2012). 3624:Journal of Thoracic Disease 3492:Drug and Alcohol Dependence 2269:Meg Neal (2 January 2015). 2182:10.1016/j.yrtph.2018.06.021 1789:of 2016. In the same year, 1653:Sendai Pageant of Starlight 1197:Japan Tobacco International 1052:Philip Morris International 920: 900:measures have directed the 879:Philip Morris International 521:Philip Morris International 156:conditions to do so are met 95:to comply with Knowledge's 10: 8396: 7366:Glantz, Stanton A (2018). 6362:CSD Staff (4 March 2015). 5461:R. J. Reynolds Tobacco Co. 1816:Tobacco Products Directive 1732:Smaller, smarter, sleeker 924: 756: 386:volatile organic compounds 369: 346:With an assorted range of 29: 8380:Tobacco smoke carcinogens 8304: 8268: 8213:Plain cigarette packaging 8198: 8118: 8060: 8037:Schizophrenia and smoking 7997: 7954: 7908: 7877: 7864: 7820: 6652:. Reuters. Archived from 6501:"Review: Ploom Model Two" 6364:"Consumer-Centric Vaping" 6345:"Consumer-Centric Vaping" 6163:10.1016/j.rmr.2018.10.010 5745:. ADVFN. 24 October 2016. 5032:10.1186/s13065-015-0096-1 5019:Chemistry Central Journal 4974:10.3109/00016341003605719 4767:"Marlboro Kicks Some Ash" 4313:10.1007/s00103-018-2827-7 3705:World Health Organization 3562:10.1186/s12889-019-6957-0 3419:. Kogan Page Publishers. 2993:10.1016/j.rmr.2018.10.010 2869:10.2196/publichealth.7359 2635:10.1007/s00103-018-2823-y 2395:10.1007/s00204-018-2215-y 1906:World Health Organization 1270: 1127: 328:World Health Organization 259:World Health Organization 218:. These products contain 8228:Tobacco control movement 7096:10.1177/2158244019898823 6986:speccomm (28 May 2019). 6370:. Harbor Communications. 2218:Respirology Case Reports 1870: 1840:Liberal Democratic Party 1785:(FDA) as amended by the 1735:Design, elegant and fun 1223: 1214: 1202: 978:British American Tobacco 483:HTPs contain the highly 336:industry-funded research 275:UK Committee on Toxicity 108:may contain suggestions. 93:may need to be rewritten 30:Not to be confused with 8360:Heated tobacco products 8138:Disinformation playbook 7777:Heated tobacco products 6971:Shapiro, Harry (2020). 6920:Journal of Epidemiology 4812:Journal of Epidemiology 3637:10.21037/jtd.2018.07.99 3251:Environmental Pollution 2726:10.3390/children6020030 1000: 710:after use. Until 2016, 528:Northeastern University 27:Type of tobacco product 8128:Cultivation of tobacco 8078:Heated tobacco product 8052:Tobacco harm reduction 7871: 7723:The New Zealand Herald 7699:Cite journal requires 7156:JAMA Internal Medicine 7090:(1): 215824401989882. 7010:JAMA Internal Medicine 6932:10.2188/jea.JE20180116 6386:Convenience Store News 5926:JAMA Internal Medicine 5313:10.1136/tc.2007.024273 4824:10.2188/jea.JE20180040 4444:JAMA Internal Medicine 4225:Górski, Paweł (2019). 4120:(Suppl 1): s111–s117. 3467:The New Zealand Herald 3204:(Suppl 1): s102–s110. 2452:10.26633/RPSP.2018.161 2383:Archives of Toxicology 2125:10.1542/peds.2017-2383 1988:. 2016. pp. 1–66. 1665:celebrity endorsements 1656: 1573: 1232: 1157: 1144: 1010: 987:Wells Fargo Securities 971: 937: 734: 669: 479:Addiction and quitting 469:eosinophilic pneumonia 307: 208:heated tobacco product 8334:Electronic cigarettes 7870: 6311:National Public Radio 5421:Winston-Salem Journal 5139:(Suppl 1): s96–s101. 4244:10.5603/ARM.2019.0020 4039:Committee on Toxicity 3888:10.3390/toxics6030043 2790:Inhalation Toxicology 2773:Winston-Salem Journal 1922:Public Health England 1655:in Kōtōdai-kōen Park. 1650: 1631:electronic cigarettes 1566: 1250:Contents of selected 1008: 934: 925:Further information: 732: 643: 603:Nicotine can lead to 370:Further information: 356:Committee on Toxicity 352:Public Health England 348:electronic cigarettes 304: 267:Public Health England 248:various types of HTPs 8375:Philip Morris brands 8100:Electronic cigarette 7779:at Wikimedia Commons 6740:. 17 September 2020. 5582:on 14 September 2017 4524:(Suppl 1): s87–s95. 3745:(Suppl 1): s30–s36. 3630:(S22): S2588–S2592. 3048:(Suppl 1): s30–s36. 2019:(Suppl 1): s26–s29. 946:cigalike e-cigarette 630:somatosensory cortex 254:instead of tobacco. 32:Electronic cigarette 8208:Cigarette smuggling 8133:Tobacco advertising 8017:Nicotine dependence 7522:. 8 September 2017. 6990:. Tobacco Reporter. 6830:2017PLoSO..1285735C 6719:. Tobacco Reporter. 6596:. Tobacco Reporter. 6581:. Tobacco Reporter. 6019:Nikkei Asian Review 6002:. Tobacco Reporter. 5445:. 14 November 2014. 5352:Haig, Matt (2005). 3413:Haig, Matt (2003). 3371:2018Chmsp.206..568K 1763:scientific evidence 1692: 1267: 810:smokeless cigarette 743:nicotine dependence 695:thermal degradation 573:Nicotine withdrawal 380:contains levels of 232:flavoring chemicals 143:of this article is 8022:Nicotine poisoning 7872: 7502:The Jerusalem Post 7461:The Jerusalem Post 7378:(Suppl 1): s1–s6. 6686:. 6 November 2018. 6633:. 10 October 2016. 6313:. 25 January 2018. 6276:. The Motley Fool. 6106:10.3322/caac.21413 6000:"All eyes on iQOS" 5785:. The Motley Fool. 5731:. The Motley Fool. 5245:The New York Times 5210:The New York Times 3447:. 26 January 2018. 3445:Kaiser Health News 2796:(13–14): 527–533. 2504:Toxicology Letters 1858:Ministry of Health 1851:Ministry of Health 1832:Ministry of Health 1798:, director of the 1690: 1657: 1574: 1549:particulate matter 1266: 1011: 960:Firefly vaporizers 938: 735: 670: 537:nicotine addiction 402:carbonyl compounds 308: 8342: 8341: 8218:Legal smoking age 8194: 8193: 8047:Smoking cessation 7984:Smoking fetishism 7775:Media related to 7650:Otago Daily Times 7273:10.1111/add.13394 7244:. Bloomberg News. 7016:(11): 1699–1700. 6771:"TEO Instruction" 6704:. Bloomberg News. 5837:. Bloomberg News. 5800:. Market Realist. 5365:978-0-7494-4433-4 4769:. Bloomberg News. 4736:10.1111/add.13231 4366:on 11 August 2018 4307:(11): 1407–1414. 3549:BMC Public Health 3426:978-0-7494-4433-4 2628:(11): 1422–1428. 1924:. pp. 1–243. 1750: 1749: 1613:growth expected. 1538: 1537: 1187:In January 2016, 891:second-hand smoke 853:Reynolds American 666:cellulose acetate 202: 201: 194: 184: 183: 176: 123: 122: 97:quality standards 75: 16:(Redirected from 8387: 8365:Tobacco products 8322: 8321: 8312: 8311: 8276:Cigarette brands 8243:Tobacco politics 8151: 8150: 8120:Tobacco industry 8073:Herbal cigarette 8061:Related products 8042:Sidestream smoke 8032:Third-hand smoke 7807: 7800: 7793: 7784: 7783: 7774: 7758: 7752: 7746: 7745: 7733: 7727: 7726: 7725:. 14 March 2018. 7715: 7709: 7708: 7702: 7697: 7695: 7687: 7676: 7670: 7669: 7661: 7655: 7654: 7640: 7634: 7633: 7589: 7583: 7582: 7581:on 31 July 2017. 7571: 7565: 7564: 7552: 7543: 7542: 7530: 7524: 7523: 7512: 7506: 7505: 7493: 7487: 7486: 7472: 7466: 7465: 7451: 7445: 7439: 7433: 7432: 7420: 7414: 7413: 7403: 7363: 7354: 7353: 7309: 7303: 7302: 7292: 7252: 7246: 7245: 7237: 7231: 7230: 7186: 7180: 7179: 7148: 7142: 7131: 7125: 7115: 7075: 7066: 7065: 7051: 7042: 7041: 7007: 6998: 6992: 6991: 6983: 6977: 6976: 6968: 6962: 6961: 6951: 6911: 6905: 6904: 6895:Shapiro, Harry. 6892: 6886: 6875: 6869: 6859: 6841: 6824:(10): e0185735. 6809: 6786: 6785: 6783: 6781: 6767: 6761: 6760: 6759: 6755: 6748: 6742: 6741: 6730: 6721: 6720: 6717:"The heat is on" 6712: 6706: 6705: 6697: 6688: 6687: 6672: 6666: 6665: 6663: 6661: 6650:Channel NewsAsia 6641: 6635: 6634: 6631:Tobacco Reporter 6623: 6617: 6616: 6604: 6598: 6597: 6589: 6583: 6582: 6574: 6568: 6567: 6555: 6549: 6548: 6545:Business Insider 6536: 6530: 6529: 6517: 6511: 6510: 6496: 6490: 6489: 6475: 6469: 6468: 6461: 6450: 6449: 6438: 6432: 6431: 6419: 6410: 6409: 6401: 6390: 6389: 6378: 6372: 6371: 6359: 6353: 6352: 6341: 6332: 6331: 6324: 6315: 6314: 6303: 6297: 6296: 6284: 6278: 6277: 6269: 6263: 6262: 6252: 6233:10.7326/M17-0759 6212: 6206: 6205: 6198: 6192: 6191: 6165: 6141: 6135: 6134: 6108: 6084: 6075: 6074: 6029: 6023: 6022: 6010: 6004: 6003: 5995: 5989: 5988: 5984:Billings Gazette 5974: 5968: 5967: 5957: 5932:(7): 1050–1052. 5917: 5904: 5903: 5902:on 31 July 2017. 5898:. Archived from 5885: 5879: 5878: 5866: 5860: 5859: 5845: 5839: 5838: 5830: 5824: 5823: 5815: 5802: 5801: 5793: 5787: 5786: 5778: 5772: 5771: 5770:on 28 June 2014. 5753: 5747: 5746: 5739: 5733: 5732: 5724: 5718: 5717: 5709: 5700: 5699: 5698:. 22 March 2017. 5684: 5678: 5677: 5663: 5657: 5656: 5643: 5637: 5636: 5628: 5613: 5612: 5598: 5592: 5591: 5589: 5587: 5571: 5565: 5564: 5552: 5546: 5545: 5541:Business Insider 5531: 5525: 5524: 5510: 5504: 5503: 5496: 5490: 5489: 5475: 5469: 5468: 5467: 5463: 5453: 5447: 5446: 5443:Associated Press 5431: 5425: 5424: 5412: 5403: 5402: 5395: 5389: 5388: 5376: 5370: 5369: 5349: 5343: 5342: 5332: 5292: 5281: 5280: 5266: 5257: 5256: 5236: 5230: 5229: 5227: 5225: 5200: 5194: 5193: 5181: 5175: 5174: 5164: 5124: 5118: 5117: 5069: 5063: 5062: 5052: 5034: 5010: 5004: 5003: 4993: 4952: 4946: 4945: 4935: 4903: 4894: 4888: 4887: 4883: 4876: 4870: 4859: 4853: 4843: 4803: 4790: 4789: 4777: 4771: 4770: 4762: 4756: 4755: 4719: 4710: 4709: 4664: 4655: 4654: 4644: 4604: 4595: 4594: 4592: 4584: 4575: 4569: 4560: 4559: 4549: 4509: 4503: 4497: 4491: 4485: 4476: 4475: 4439: 4433: 4432: 4422: 4382: 4376: 4375: 4373: 4371: 4352: 4341: 4340: 4295: 4280: 4274: 4265: 4264: 4246: 4222: 4211: 4205: 4196: 4195: 4183: 4172: 4161: 4155: 4145: 4105: 4064: 4058: 4043: 4042: 4036: 4028: 4003: 3997: 3986: 3980: 3971: 3970: 3956: 3950: 3944: 3935: 3924: 3918: 3908: 3890: 3866: 3833: 3832: 3796: 3781: 3780: 3770: 3730: 3724: 3718: 3709: 3708: 3697: 3668: 3667: 3657: 3639: 3615: 3609: 3598: 3592: 3582: 3564: 3540: 3534: 3533: 3523: 3483: 3472: 3471: 3458: 3449: 3448: 3437: 3431: 3430: 3410: 3401: 3400: 3382: 3350: 3339: 3333: 3327: 3321: 3308: 3307: 3300: 3291: 3290: 3246: 3240: 3239: 3229: 3189: 3160: 3159: 3149: 3124:(12): CD005231. 3109: 3100: 3089: 3083: 3073: 3033: 3014: 3013: 2995: 2971: 2916: 2905: 2899: 2889: 2871: 2847: 2830: 2829: 2784: 2778: 2777: 2763: 2757: 2756: 2746: 2728: 2704: 2698: 2697: 2689: 2680: 2669: 2663: 2637: 2613: 2546: 2545: 2535: 2495: 2482: 2481: 2471: 2431: 2425: 2424: 2414: 2389:(6): 2145–2149. 2374: 2363: 2352: 2346: 2336: 2296: 2281: 2280: 2266: 2260: 2259: 2249: 2230:10.1002/rcr2.190 2209: 2203: 2202: 2184: 2160: 2154: 2153: 2127: 2118:(1): e20172383. 2103: 2080: 2079: 2061: 2055: 2054: 2044: 2004: 1989: 1983: 1973: 1971: 1969: 1963: 1956: 1947: 1946:on 17 June 2019. 1945: 1934: 1925: 1919: 1909: 1903: 1885: 1881: 1796:Mitchell H. Katz 1699:Marketing terms 1693: 1689: 1626: 1591:Tobacco industry 1268: 1265: 1237:The TEO heats a 1183:Ploom vaporizers 1135: 1119:iSmoke OneHitter 1085:propylene glycol 1054:(PMI) under the 1046: 1041: 1040: 1037: 1036: 1033: 1030: 1027: 1024: 902:tobacco industry 787: 769: 610:pancreatic islet 605:vasoconstriction 517:tobacco industry 493:quitting smoking 197: 190: 179: 172: 168: 165: 159: 133: 132: 125: 118: 115: 109: 86: 78: 67: 45: 44: 37: 21: 8395: 8394: 8390: 8389: 8388: 8386: 8385: 8384: 8355:Cigarette types 8345: 8344: 8343: 8338: 8300: 8264: 8200: 8190: 8149: 8114: 8068:Candy cigarette 8056: 8027:Passive smoking 7993: 7989:Tobacco smoking 7950: 7946:Vending machine 7904: 7873: 7862: 7816: 7811: 7767: 7762: 7761: 7753: 7749: 7734: 7730: 7717: 7716: 7712: 7700: 7698: 7689: 7688: 7678: 7677: 7673: 7662: 7658: 7641: 7637: 7590: 7586: 7573: 7572: 7568: 7553: 7546: 7539:The Korea Times 7531: 7527: 7520:The Japan Times 7514: 7513: 7509: 7494: 7490: 7473: 7469: 7452: 7448: 7440: 7436: 7421: 7417: 7372:Tobacco Control 7364: 7357: 7314:Tobacco Control 7310: 7306: 7253: 7249: 7238: 7234: 7191:Tobacco Control 7187: 7183: 7149: 7145: 7076: 7069: 7052: 7045: 7005: 6999: 6995: 6984: 6980: 6969: 6965: 6926:(11): 444–450. 6912: 6908: 6893: 6889: 6810: 6789: 6779: 6777: 6769: 6768: 6764: 6757: 6749: 6745: 6732: 6731: 6724: 6713: 6709: 6698: 6691: 6674: 6673: 6669: 6659: 6657: 6656:on 31 July 2017 6642: 6638: 6625: 6624: 6620: 6605: 6601: 6590: 6586: 6575: 6571: 6556: 6552: 6537: 6533: 6518: 6514: 6497: 6493: 6476: 6472: 6463: 6462: 6453: 6440: 6439: 6435: 6420: 6413: 6408:. Tobacco Asia. 6402: 6393: 6380: 6379: 6375: 6360: 6356: 6343: 6342: 6335: 6326: 6325: 6318: 6305: 6304: 6300: 6285: 6281: 6270: 6266: 6213: 6209: 6200: 6199: 6195: 6142: 6138: 6085: 6078: 6030: 6026: 6011: 6007: 5996: 5992: 5975: 5971: 5918: 5907: 5895:The Korea Times 5886: 5882: 5867: 5863: 5846: 5842: 5831: 5827: 5816: 5805: 5794: 5790: 5779: 5775: 5754: 5750: 5741: 5740: 5736: 5725: 5721: 5710: 5703: 5692:The Japan Times 5686: 5685: 5681: 5664: 5660: 5645: 5644: 5640: 5629: 5616: 5599: 5595: 5585: 5583: 5572: 5568: 5561:The Motley Fool 5553: 5549: 5532: 5528: 5511: 5507: 5498: 5497: 5493: 5476: 5472: 5465: 5454: 5450: 5433: 5432: 5428: 5413: 5406: 5397: 5396: 5392: 5377: 5373: 5366: 5350: 5346: 5301:Tobacco Control 5293: 5284: 5267: 5260: 5237: 5233: 5223: 5221: 5201: 5197: 5182: 5178: 5133:Tobacco Control 5125: 5121: 5078:Tobacco Control 5070: 5066: 5011: 5007: 4953: 4949: 4904: 4897: 4885: 4878: 4877: 4873: 4804: 4793: 4778: 4774: 4763: 4759: 4720: 4713: 4665: 4658: 4619:(e1): e25–e33. 4613:Tobacco Control 4605: 4598: 4590: 4586: 4585: 4578: 4570: 4563: 4518:Tobacco Control 4510: 4506: 4498: 4494: 4486: 4479: 4440: 4436: 4391:Tobacco Control 4383: 4379: 4369: 4367: 4354: 4353: 4344: 4296: 4283: 4275: 4268: 4223: 4214: 4206: 4199: 4184: 4175: 4114:Tobacco Control 4106: 4067: 4059: 4046: 4034: 4030: 4029: 4006: 3998: 3989: 3981: 3974: 3957: 3953: 3945: 3938: 3867: 3836: 3801:Tobacco Control 3797: 3784: 3739:Tobacco Control 3731: 3727: 3719: 3712: 3699: 3698: 3671: 3616: 3612: 3541: 3537: 3484: 3475: 3460: 3459: 3452: 3439: 3438: 3434: 3427: 3411: 3404: 3351: 3342: 3334: 3330: 3322: 3311: 3302: 3301: 3294: 3247: 3243: 3198:Tobacco Control 3190: 3163: 3110: 3103: 3042:Tobacco Control 3034: 3017: 2972: 2919: 2848: 2833: 2785: 2781: 2764: 2760: 2705: 2701: 2690: 2683: 2614: 2549: 2496: 2485: 2432: 2428: 2375: 2366: 2305:Tobacco Control 2297: 2284: 2267: 2263: 2210: 2206: 2161: 2157: 2104: 2083: 2071:The Japan Times 2062: 2058: 2013:Tobacco Control 2005: 2001: 1996: 1981: 1967: 1965: 1964:on 8 March 2021 1961: 1954: 1943: 1932: 1917: 1901: 1894: 1889: 1888: 1882: 1878: 1873: 1804:Tobacco control 1771: 1754:tobacco control 1702:Product appeal 1645: 1634: 1627: 1610:Google searches 1595:tobacco control 1561: 1543: 1541: 1248: 1239:cigarette stick 1235: 1226: 1217: 1209:Imperial Brands 1205: 1185: 1173: 1160: 1147: 1130: 1121: 1112:clinical trials 1044: 1021: 1017: 1003: 982:heating element 974: 962: 929: 923: 898:tobacco control 849:viral marketing 820:past processed 798: 797: 796: 795: 794: 788: 779: 778: 777: 770: 759: 687:carbon monoxide 648:. 70% tobacco, 638: 598:adverse effects 581: 553: 481: 422:carbon monoxide 374: 368: 360:completely stop 317:adverse effects 312:Cochrane review 299: 279:completely stop 198: 187: 186: 185: 180: 169: 163: 160: 149: 134: 130: 119: 113: 110: 100: 87: 46: 42: 35: 28: 23: 22: 15: 12: 11: 5: 8393: 8383: 8382: 8377: 8372: 8367: 8362: 8357: 8340: 8339: 8337: 8336: 8331: 8326: 8316: 8305: 8302: 8301: 8299: 8298: 8293: 8291:Rolling papers 8288: 8283: 8278: 8272: 8270: 8266: 8265: 8263: 8262: 8261: 8260: 8255: 8245: 8240: 8235: 8230: 8225: 8220: 8215: 8210: 8204: 8202: 8196: 8195: 8192: 8191: 8189: 8188: 8183: 8178: 8173: 8168: 8163: 8157: 8155: 8148: 8147: 8140: 8135: 8130: 8124: 8122: 8116: 8115: 8113: 8112: 8107: 8105:Nicotine pouch 8102: 8097: 8092: 8091: 8090: 8085: 8075: 8070: 8064: 8062: 8058: 8057: 8055: 8054: 8049: 8044: 8039: 8034: 8029: 8024: 8019: 8014: 8009: 8003: 8001: 7995: 7994: 7992: 7991: 7986: 7981: 7976: 7971: 7966: 7964:Cigarette card 7960: 7958: 7952: 7951: 7949: 7948: 7943: 7938: 7933: 7928: 7923: 7918: 7912: 7910: 7906: 7905: 7903: 7902: 7897: 7892: 7887: 7881: 7879: 7875: 7874: 7865: 7863: 7861: 7860: 7855: 7850: 7845: 7840: 7835: 7830: 7824: 7822: 7818: 7817: 7810: 7809: 7802: 7795: 7787: 7781: 7780: 7766: 7765:External links 7763: 7760: 7759: 7747: 7728: 7710: 7701:|journal= 7671: 7656: 7635: 7600:(6): S19–S27. 7584: 7566: 7544: 7525: 7507: 7488: 7467: 7446: 7444:, p. 201. 7434: 7415: 7355: 7304: 7247: 7232: 7181: 7143: 7067: 7043: 6993: 6978: 6963: 6906: 6887: 6787: 6762: 6743: 6722: 6707: 6689: 6667: 6636: 6618: 6599: 6584: 6569: 6550: 6531: 6512: 6491: 6470: 6451: 6433: 6411: 6391: 6373: 6354: 6333: 6316: 6298: 6279: 6264: 6227:(4): 278–280. 6207: 6193: 6136: 6099:(6): 449–471. 6076: 6024: 6005: 5990: 5969: 5905: 5880: 5861: 5840: 5825: 5803: 5788: 5773: 5748: 5734: 5719: 5701: 5679: 5658: 5655:. 11 May 2019. 5638: 5614: 5593: 5566: 5547: 5526: 5505: 5491: 5470: 5448: 5426: 5404: 5390: 5371: 5364: 5344: 5307:(4): 222–229. 5282: 5258: 5231: 5195: 5176: 5119: 5064: 5005: 4968:(4): 454–464. 4947: 4895: 4871: 4818:(5): 274–275. 4791: 4772: 4757: 4730:(4): 706–713. 4711: 4676:(4): 551–554. 4656: 4596: 4576: 4561: 4504: 4502:, p. 210. 4492: 4490:, p. 208. 4477: 4434: 4397:(5): 582–594. 4377: 4342: 4281: 4279:, p. 219. 4266: 4237:(2): 123–134. 4212: 4197: 4173: 4065: 4044: 4004: 4002:, p. 220. 3987: 3972: 3951: 3936: 3834: 3807:(5): 609–610. 3782: 3725: 3710: 3669: 3610: 3535: 3473: 3470:. 18 May 2017. 3450: 3432: 3425: 3402: 3340: 3328: 3309: 3292: 3241: 3161: 3101: 3015: 2917: 2831: 2779: 2758: 2699: 2681: 2547: 2483: 2426: 2364: 2282: 2261: 2204: 2155: 2081: 2076:Bloomberg News 2056: 1998: 1997: 1995: 1992: 1991: 1990: 1974: 1948: 1926: 1910: 1893: 1890: 1887: 1886: 1875: 1874: 1872: 1869: 1808:Stanton Glantz 1770: 1767: 1748: 1747: 1744: 1741: 1737: 1736: 1733: 1730: 1726: 1725: 1722: 1719: 1715: 1714: 1711: 1708: 1704: 1703: 1700: 1697: 1644: 1641: 1636: 1635: 1628: 1621: 1560: 1557: 1536: 1535: 1532: 1529: 1526: 1523: 1519: 1518: 1515: 1512: 1509: 1506: 1502: 1501: 1498: 1495: 1492: 1489: 1485: 1484: 1481: 1478: 1475: 1472: 1468: 1467: 1464: 1461: 1458: 1455: 1451: 1450: 1447: 1444: 1441: 1438: 1437:Crotonaldehyde 1434: 1433: 1430: 1427: 1424: 1421: 1417: 1416: 1413: 1410: 1407: 1404: 1400: 1399: 1396: 1393: 1390: 1387: 1383: 1382: 1379: 1376: 1373: 1370: 1366: 1365: 1362: 1359: 1356: 1353: 1349: 1348: 1345: 1342: 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J. Reynolds 973: 970: 961: 958: 922: 919: 806:R. J. Reynolds 789: 782: 781: 780: 771: 764: 763: 762: 761: 760: 758: 755: 683:carbon dioxide 637: 634: 580: 577: 552: 551:Nicotine yield 549: 541:harm reduction 500:gateway effect 480: 477: 367: 364: 298: 297:Health effects 295: 200: 199: 182: 181: 137: 135: 128: 121: 120: 90: 88: 81: 76: 50: 49: 47: 40: 26: 18:Heated tobacco 9: 6: 4: 3: 2: 8392: 8381: 8378: 8376: 8373: 8371: 8368: 8366: 8363: 8361: 8358: 8356: 8353: 8352: 8350: 8335: 8332: 8330: 8327: 8325: 8317: 8315: 8307: 8306: 8303: 8297: 8294: 8292: 8289: 8287: 8284: 8282: 8279: 8277: 8274: 8273: 8271: 8267: 8259: 8256: 8254: 8251: 8250: 8249: 8246: 8244: 8241: 8239: 8236: 8234: 8231: 8229: 8226: 8224: 8221: 8219: 8216: 8214: 8211: 8209: 8206: 8205: 8203: 8197: 8187: 8186:United States 8184: 8182: 8179: 8177: 8174: 8172: 8169: 8167: 8164: 8162: 8159: 8158: 8156: 8152: 8145: 8141: 8139: 8136: 8134: 8131: 8129: 8126: 8125: 8123: 8121: 8117: 8111: 8108: 8106: 8103: 8101: 8098: 8096: 8093: 8089: 8086: 8084: 8081: 8080: 8079: 8076: 8074: 8071: 8069: 8066: 8065: 8063: 8059: 8053: 8050: 8048: 8045: 8043: 8040: 8038: 8035: 8033: 8030: 8028: 8025: 8023: 8020: 8018: 8015: 8013: 8010: 8008: 8007:Chain smoking 8005: 8004: 8002: 8000: 7999:Health issues 7996: 7990: 7987: 7985: 7982: 7980: 7977: 7975: 7972: 7970: 7967: 7965: 7962: 7961: 7959: 7957: 7953: 7947: 7944: 7942: 7939: 7937: 7934: 7932: 7929: 7927: 7924: 7922: 7919: 7917: 7914: 7913: 7911: 7907: 7901: 7898: 7896: 7893: 7891: 7890:Rolling paper 7888: 7886: 7883: 7882: 7880: 7876: 7869: 7859: 7856: 7854: 7851: 7849: 7846: 7844: 7841: 7839: 7836: 7834: 7831: 7829: 7826: 7825: 7823: 7819: 7815: 7808: 7803: 7801: 7796: 7794: 7789: 7788: 7785: 7778: 7773: 7769: 7768: 7757:, p. ii. 7756: 7751: 7743: 7739: 7732: 7724: 7720: 7714: 7706: 7693: 7685: 7681: 7675: 7668:. VapingPost. 7667: 7660: 7652: 7651: 7646: 7639: 7631: 7627: 7623: 7619: 7615: 7611: 7607: 7603: 7599: 7595: 7588: 7580: 7576: 7570: 7562: 7558: 7551: 7549: 7540: 7536: 7529: 7521: 7517: 7511: 7503: 7499: 7492: 7484: 7483: 7478: 7471: 7463: 7462: 7457: 7450: 7443: 7438: 7430: 7426: 7419: 7411: 7407: 7402: 7397: 7393: 7389: 7385: 7381: 7377: 7373: 7369: 7362: 7360: 7351: 7347: 7343: 7339: 7335: 7331: 7327: 7323: 7319: 7315: 7308: 7300: 7296: 7291: 7286: 7282: 7278: 7274: 7270: 7266: 7262: 7258: 7251: 7243: 7236: 7228: 7224: 7220: 7216: 7212: 7208: 7204: 7200: 7196: 7192: 7185: 7177: 7173: 7169: 7165: 7161: 7157: 7153: 7147: 7141: 7139: 7135: 7130: 7123: 7119: 7114: 7109: 7105: 7101: 7097: 7093: 7089: 7085: 7081: 7074: 7072: 7063: 7062: 7057: 7050: 7048: 7039: 7035: 7031: 7027: 7023: 7019: 7015: 7011: 7004: 6997: 6989: 6982: 6974: 6967: 6959: 6955: 6950: 6945: 6941: 6937: 6933: 6929: 6925: 6921: 6917: 6910: 6902: 6898: 6891: 6885: 6883: 6879: 6874: 6867: 6863: 6858: 6853: 6849: 6845: 6840: 6835: 6831: 6827: 6823: 6819: 6815: 6808: 6806: 6804: 6802: 6800: 6798: 6796: 6794: 6792: 6776: 6772: 6766: 6753: 6747: 6739: 6735: 6729: 6727: 6718: 6711: 6703: 6696: 6694: 6685: 6681: 6677: 6671: 6655: 6651: 6647: 6640: 6632: 6628: 6622: 6614: 6610: 6603: 6595: 6588: 6580: 6573: 6565: 6561: 6554: 6546: 6542: 6535: 6527: 6523: 6516: 6508: 6507: 6502: 6495: 6487: 6486: 6481: 6474: 6466: 6460: 6458: 6456: 6447: 6443: 6437: 6429: 6425: 6418: 6416: 6407: 6400: 6398: 6396: 6387: 6383: 6377: 6369: 6365: 6358: 6350: 6346: 6340: 6338: 6329: 6323: 6321: 6312: 6308: 6302: 6294: 6290: 6283: 6275: 6268: 6260: 6256: 6251: 6246: 6242: 6238: 6234: 6230: 6226: 6222: 6218: 6211: 6203: 6197: 6189: 6185: 6181: 6177: 6173: 6169: 6164: 6159: 6156:(1): 82–103. 6155: 6151: 6147: 6140: 6132: 6128: 6124: 6120: 6116: 6112: 6107: 6102: 6098: 6094: 6090: 6083: 6081: 6072: 6068: 6064: 6060: 6056: 6052: 6048: 6044: 6040: 6036: 6028: 6020: 6016: 6009: 6001: 5994: 5986: 5985: 5980: 5973: 5965: 5961: 5956: 5951: 5947: 5943: 5939: 5935: 5931: 5927: 5923: 5916: 5914: 5912: 5910: 5901: 5897: 5896: 5891: 5884: 5876: 5872: 5865: 5857: 5856: 5851: 5844: 5836: 5829: 5821: 5814: 5812: 5810: 5808: 5799: 5792: 5784: 5777: 5769: 5765: 5764: 5759: 5752: 5744: 5738: 5730: 5723: 5716:. 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VapingPost. 5634: 5627: 5625: 5623: 5621: 5619: 5610: 5609: 5604: 5597: 5581: 5577: 5570: 5562: 5558: 5551: 5543: 5542: 5537: 5530: 5522: 5521: 5516: 5509: 5501: 5495: 5487: 5486: 5481: 5474: 5462: 5458: 5452: 5444: 5440: 5436: 5430: 5422: 5418: 5411: 5409: 5400: 5394: 5386: 5382: 5375: 5367: 5361: 5357: 5356: 5348: 5340: 5336: 5331: 5326: 5322: 5318: 5314: 5310: 5306: 5302: 5298: 5291: 5289: 5287: 5278: 5277: 5272: 5265: 5263: 5254: 5250: 5246: 5242: 5235: 5220: 5216: 5212: 5211: 5206: 5199: 5191: 5187: 5180: 5172: 5168: 5163: 5158: 5154: 5150: 5146: 5142: 5138: 5134: 5130: 5123: 5115: 5111: 5107: 5103: 5099: 5095: 5091: 5087: 5083: 5079: 5075: 5068: 5060: 5056: 5051: 5046: 5042: 5038: 5033: 5028: 5024: 5020: 5016: 5009: 5001: 4997: 4992: 4987: 4983: 4979: 4975: 4971: 4967: 4963: 4959: 4951: 4943: 4939: 4934: 4929: 4925: 4921: 4918:(3): 271–80. 4917: 4913: 4909: 4902: 4900: 4892: 4891:public domain 4881: 4875: 4869: 4867: 4863: 4858: 4851: 4847: 4842: 4837: 4833: 4829: 4825: 4821: 4817: 4813: 4809: 4802: 4800: 4798: 4796: 4787: 4783: 4776: 4768: 4761: 4753: 4749: 4745: 4741: 4737: 4733: 4729: 4725: 4718: 4716: 4707: 4703: 4699: 4695: 4691: 4687: 4683: 4679: 4675: 4671: 4663: 4661: 4652: 4648: 4643: 4638: 4634: 4630: 4626: 4622: 4618: 4614: 4610: 4603: 4601: 4589: 4583: 4581: 4573: 4568: 4566: 4557: 4553: 4548: 4543: 4539: 4535: 4531: 4527: 4523: 4519: 4515: 4508: 4501: 4496: 4489: 4484: 4482: 4473: 4469: 4465: 4461: 4457: 4453: 4449: 4445: 4438: 4430: 4426: 4421: 4416: 4412: 4408: 4404: 4400: 4396: 4392: 4388: 4381: 4365: 4361: 4357: 4351: 4349: 4347: 4338: 4334: 4330: 4326: 4322: 4318: 4314: 4310: 4306: 4303:(in German). 4302: 4294: 4292: 4290: 4288: 4286: 4278: 4273: 4271: 4262: 4258: 4254: 4250: 4245: 4240: 4236: 4232: 4228: 4221: 4219: 4217: 4209: 4204: 4202: 4193: 4189: 4182: 4180: 4178: 4171: 4169: 4165: 4160: 4153: 4149: 4144: 4139: 4135: 4131: 4127: 4123: 4119: 4115: 4111: 4104: 4102: 4100: 4098: 4096: 4094: 4092: 4090: 4088: 4086: 4084: 4082: 4080: 4078: 4076: 4074: 4072: 4070: 4063:, p. 23. 4062: 4057: 4055: 4053: 4051: 4049: 4040: 4033: 4027: 4025: 4023: 4021: 4019: 4017: 4015: 4013: 4011: 4009: 4001: 3996: 3994: 3992: 3984: 3979: 3977: 3968: 3967: 3962: 3955: 3948: 3943: 3941: 3934: 3932: 3928: 3923: 3916: 3912: 3907: 3902: 3898: 3894: 3889: 3884: 3880: 3876: 3872: 3865: 3863: 3861: 3859: 3857: 3855: 3853: 3851: 3849: 3847: 3845: 3843: 3841: 3839: 3830: 3826: 3822: 3818: 3814: 3810: 3806: 3802: 3795: 3793: 3791: 3789: 3787: 3778: 3774: 3769: 3764: 3760: 3756: 3752: 3748: 3744: 3740: 3736: 3729: 3723:, p. 54. 3722: 3717: 3715: 3706: 3702: 3696: 3694: 3692: 3690: 3688: 3686: 3684: 3682: 3680: 3678: 3676: 3674: 3665: 3661: 3656: 3651: 3647: 3643: 3638: 3633: 3629: 3625: 3621: 3614: 3608: 3606: 3602: 3597: 3590: 3586: 3581: 3576: 3572: 3568: 3563: 3558: 3554: 3550: 3546: 3539: 3531: 3527: 3522: 3517: 3513: 3509: 3505: 3501: 3497: 3493: 3489: 3482: 3480: 3478: 3469: 3468: 3463: 3457: 3455: 3446: 3442: 3436: 3428: 3422: 3418: 3417: 3409: 3407: 3398: 3394: 3390: 3386: 3381: 3376: 3372: 3368: 3364: 3360: 3356: 3349: 3347: 3345: 3338:, p. 30. 3337: 3332: 3326:, p. 36. 3325: 3320: 3318: 3316: 3314: 3305: 3299: 3297: 3288: 3284: 3280: 3276: 3272: 3268: 3264: 3260: 3256: 3252: 3245: 3237: 3233: 3228: 3223: 3219: 3215: 3211: 3207: 3203: 3199: 3195: 3188: 3186: 3184: 3182: 3180: 3178: 3176: 3174: 3172: 3170: 3168: 3166: 3157: 3153: 3148: 3143: 3139: 3135: 3131: 3127: 3123: 3119: 3115: 3108: 3106: 3099: 3097: 3093: 3088: 3081: 3077: 3072: 3067: 3063: 3059: 3055: 3051: 3047: 3043: 3039: 3032: 3030: 3028: 3026: 3024: 3022: 3020: 3011: 3007: 3003: 2999: 2994: 2989: 2986:(1): 82–103. 2985: 2982:(in French). 2981: 2977: 2970: 2968: 2966: 2964: 2962: 2960: 2958: 2956: 2954: 2952: 2950: 2948: 2946: 2944: 2942: 2940: 2938: 2936: 2934: 2932: 2930: 2928: 2926: 2924: 2922: 2915: 2913: 2909: 2904: 2897: 2893: 2888: 2883: 2879: 2875: 2870: 2865: 2861: 2857: 2853: 2846: 2844: 2842: 2840: 2838: 2836: 2827: 2823: 2819: 2815: 2811: 2807: 2803: 2799: 2795: 2791: 2783: 2775: 2774: 2769: 2762: 2754: 2750: 2745: 2740: 2736: 2732: 2727: 2722: 2718: 2714: 2710: 2703: 2696:. VapingPost. 2695: 2688: 2686: 2679: 2677: 2673: 2668: 2661: 2657: 2653: 2649: 2645: 2641: 2636: 2631: 2627: 2624:(in German). 2623: 2619: 2612: 2610: 2608: 2606: 2604: 2602: 2600: 2598: 2596: 2594: 2592: 2590: 2588: 2586: 2584: 2582: 2580: 2578: 2576: 2574: 2572: 2570: 2568: 2566: 2564: 2562: 2560: 2558: 2556: 2554: 2552: 2543: 2539: 2534: 2529: 2525: 2521: 2517: 2513: 2509: 2505: 2501: 2494: 2492: 2490: 2488: 2479: 2475: 2470: 2465: 2461: 2457: 2453: 2449: 2445: 2441: 2437: 2430: 2422: 2418: 2413: 2408: 2404: 2400: 2396: 2392: 2388: 2384: 2380: 2373: 2371: 2369: 2362: 2360: 2356: 2351: 2344: 2340: 2335: 2330: 2326: 2322: 2318: 2314: 2310: 2306: 2302: 2295: 2293: 2291: 2289: 2287: 2278: 2277: 2272: 2265: 2257: 2253: 2248: 2243: 2239: 2235: 2231: 2227: 2224:(6): e00190. 2223: 2219: 2215: 2208: 2200: 2196: 2192: 2188: 2183: 2178: 2174: 2170: 2166: 2159: 2151: 2147: 2143: 2139: 2135: 2131: 2126: 2121: 2117: 2113: 2109: 2102: 2100: 2098: 2096: 2094: 2092: 2090: 2088: 2086: 2077: 2073: 2072: 2067: 2060: 2052: 2048: 2043: 2038: 2034: 2030: 2026: 2022: 2018: 2014: 2010: 2003: 1999: 1987: 1979: 1975: 1960: 1953: 1949: 1942: 1938: 1931: 1927: 1923: 1916: 1911: 1907: 1900: 1896: 1895: 1880: 1876: 1868: 1865: 1863: 1859: 1854: 1852: 1848: 1843: 1841: 1835: 1833: 1828: 1825: 1819: 1817: 1812: 1809: 1805: 1801: 1797: 1792: 1788: 1784: 1779: 1776: 1766: 1764: 1758: 1755: 1745: 1743:Reduced risk 1742: 1739: 1738: 1734: 1731: 1728: 1727: 1723: 1721:Reduced risk 1720: 1717: 1716: 1712: 1709: 1706: 1705: 1701: 1698: 1696:Product name 1695: 1694: 1688: 1684: 1680: 1676: 1672: 1670: 1669:Judith Mackay 1666: 1661: 1654: 1649: 1640: 1632: 1625: 1620: 1619: 1618: 1614: 1611: 1607: 1603: 1598: 1596: 1592: 1588: 1585: 1581: 1579: 1572: 1570: 1565: 1556: 1554: 1550: 1546: 1533: 1530: 1527: 1524: 1521: 1520: 1516: 1513: 1510: 1507: 1504: 1503: 1499: 1496: 1493: 1490: 1487: 1486: 1482: 1479: 1476: 1473: 1470: 1469: 1465: 1462: 1459: 1456: 1454:1.3-Butadiene 1453: 1452: 1448: 1445: 1442: 1439: 1436: 1435: 1431: 1428: 1425: 1422: 1419: 1418: 1414: 1411: 1408: 1405: 1402: 1401: 1397: 1394: 1391: 1388: 1385: 1384: 1380: 1377: 1374: 1371: 1368: 1367: 1363: 1360: 1357: 1354: 1351: 1350: 1346: 1343: 1340: 1337: 1334: 1333: 1329: 1326: 1323: 1320: 1317: 1316: 1312: 1309: 1306: 1303: 1300: 1299: 1295: 1292: 1289: 1286: 1283: 1282: 1278: 1275: 1272: 1269: 1264: 1262: 1258: 1253: 1243: 1240: 1230: 1221: 1212: 1210: 1200: 1198: 1193: 1190: 1189:Japan Tobacco 1180: 1178: 1168: 1165: 1164:China Tobacco 1162:In May 2019, 1155: 1152: 1142: 1140: 1125: 1116: 1113: 1109: 1105: 1100: 1098: 1094: 1088: 1086: 1080: 1077: 1073: 1070:, Japan, and 1069: 1064: 1061: 1057: 1053: 1049: 1048: 1039: 1015: 1007: 998: 994: 992: 988: 983: 979: 969: 967: 957: 955: 949: 947: 943: 933: 928: 918: 916: 910: 908: 903: 899: 894: 892: 888: 884: 880: 875: 873: 869: 863: 861: 860:Japan Tobacco 856: 854: 850: 846: 841: 839: 835: 831: 828:to create an 827: 823: 819: 815: 814:test-marketed 811: 807: 803: 792: 791:Philip Morris 786: 775: 774:Japan Tobacco 768: 754: 752: 746: 744: 740: 731: 727: 725: 719: 715: 713: 709: 705: 699: 696: 690: 689:, and water. 688: 684: 680: 676: 667: 663: 659: 655: 651: 647: 642: 633: 631: 627: 623: 619: 615: 611: 606: 601: 599: 595: 591: 586: 576: 574: 570: 565: 563: 557: 548: 544: 542: 538: 532: 529: 524: 522: 518: 512: 508: 505: 501: 496: 494: 490: 486: 476: 472: 470: 466: 462: 458: 454: 450: 446: 445: 438: 435: 429: 427: 423: 419: 415: 411: 407: 403: 399: 395: 391: 387: 383: 379: 373: 363: 361: 357: 353: 349: 344: 341: 337: 333: 329: 324: 320: 318: 313: 303: 294: 292: 286: 284: 280: 276: 272: 268: 264: 260: 255: 253: 249: 245: 239: 237: 233: 229: 225: 221: 217: 213: 209: 204: 196: 193: 178: 175: 167: 157: 153: 147: 146: 142: 136: 127: 126: 117: 107: 103: 98: 94: 91:This article 89: 85: 80: 79: 74: 72: 65: 64: 59: 58: 53: 48: 39: 38: 33: 19: 8296:Smoking bans 8077: 7750: 7741: 7731: 7722: 7713: 7692:cite journal 7683: 7674: 7659: 7648: 7638: 7597: 7593: 7587: 7579:the original 7569: 7538: 7528: 7519: 7510: 7501: 7491: 7480: 7470: 7459: 7449: 7442:McNeill 2018 7437: 7428: 7418: 7375: 7371: 7317: 7313: 7307: 7264: 7260: 7250: 7235: 7194: 7190: 7184: 7162:(1): 15–16. 7159: 7155: 7146: 7126: 7087: 7083: 7061:The Standard 7059: 7013: 7009: 6996: 6988:"Heating up" 6981: 6966: 6923: 6919: 6909: 6900: 6890: 6870: 6821: 6817: 6778:. Retrieved 6774: 6765: 6746: 6737: 6710: 6670: 6658:. Retrieved 6654:the original 6639: 6630: 6621: 6612: 6602: 6587: 6572: 6553: 6544: 6534: 6525: 6515: 6504: 6494: 6483: 6473: 6436: 6428:The Investor 6385: 6376: 6367: 6357: 6348: 6301: 6292: 6282: 6267: 6224: 6220: 6210: 6196: 6153: 6149: 6139: 6096: 6092: 6041:(2): 81–87. 6038: 6034: 6027: 6018: 6008: 5993: 5982: 5972: 5929: 5925: 5900:the original 5893: 5883: 5864: 5853: 5843: 5828: 5791: 5776: 5768:the original 5761: 5751: 5737: 5722: 5691: 5682: 5671: 5661: 5650: 5641: 5608:The Guardian 5606: 5596: 5584:. Retrieved 5580:the original 5569: 5550: 5539: 5529: 5518: 5508: 5494: 5483: 5473: 5451: 5429: 5420: 5393: 5384: 5374: 5354: 5347: 5304: 5300: 5274: 5244: 5234: 5222:. Retrieved 5208: 5198: 5179: 5136: 5132: 5122: 5081: 5077: 5067: 5022: 5018: 5008: 4965: 4961: 4950: 4915: 4911: 4874: 4854: 4815: 4811: 4785: 4775: 4760: 4727: 4723: 4673: 4669: 4616: 4612: 4574:, p. 5. 4521: 4517: 4507: 4500:McNeill 2018 4495: 4488:McNeill 2018 4447: 4443: 4437: 4394: 4390: 4380: 4368:. Retrieved 4364:the original 4304: 4300: 4277:McNeill 2018 4234: 4230: 4210:, p. 5. 4191: 4156: 4117: 4113: 4061:McNeill 2018 4000:McNeill 2018 3985:, p. 6. 3964: 3954: 3949:, p. 4. 3919: 3878: 3874: 3804: 3800: 3742: 3738: 3728: 3627: 3623: 3613: 3593: 3552: 3548: 3538: 3495: 3491: 3465: 3435: 3415: 3362: 3358: 3336:McNeill 2018 3331: 3254: 3250: 3244: 3201: 3197: 3121: 3117: 3084: 3045: 3041: 2983: 2979: 2900: 2859: 2855: 2793: 2789: 2782: 2771: 2761: 2716: 2712: 2702: 2664: 2625: 2621: 2507: 2503: 2443: 2439: 2429: 2386: 2382: 2347: 2308: 2304: 2274: 2264: 2221: 2217: 2207: 2172: 2168: 2158: 2115: 2111: 2069: 2059: 2016: 2012: 2002: 1966:. 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