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when they demonstrated that astrocytes and endothelial cells during stroke are able to create a permissive environment for neural regeneration, that is most striking for exogenous transplanted neural stem cells. Previous work by the Snyder
Laboratory have shown that the interactions between NSCs and
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More recently these findings have been reproduced and extended by others to different models of CNS injury, such as experimental autoimmune encephalomyelitis (EAE), a model of
Multiple sclerosis, where transplanted neural stem cells persisted undifferentiated in perivascular areas, also called
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is a cellular microenvironments generated during tissue injury. These environments are triggered by injury and the local responses of support cells, and enable the possibility of repair by endogenous or transplanted neural stem cells. These environments have been demonstrated in several injury
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local cells is reciprocal, underlying a bystander beneficial effect of neural stem cells without neural differentiation, once thought to be the only mechanism for therapeutical benefit of stem cells in CNS injury.
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Imitola, Jaime; Raddassi, Khadir; Park, Kook In; Mueller, Franz-Josef; Nieto, Marta; Teng, Yang D.; Frenkel, Dan; Li, Jianxue; Sidman, Richard L.; Walsh, Christopher A.; Snyder, Evan Y.; Khoury, Samia J. (2004).
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Park, Kook In; Teng, Yang D.; Snyder, Evan Y. (2002). "The injured brain interacts reciprocally with neural stem cells supported by scaffolds to reconstitute lost tissue".
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132:"Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1α/CXC chemokine receptor 4 pathway"
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296:"Remodelling the injured CNS through the establishment of atypical ectopic perivascular neural stem cell niches"
265:"Remodelling the injured CNS through the establishment of atypical ectopic perivascular neural stem cell niches"
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Pluchino, S.; Cusimano, M.; Bacigaluppi, M.; Martino, G. (June 2010).
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Pluchino, S.; Cusimano, M.; Bacigaluppi, M.; Martino, G. (June 2010).
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Pluchino, S; Cusimano, M; Bacigaluppi, M; Martino, G (2010).
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models, most notable in the CNS. The term was coined by
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may be too technical for most readers to understand
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