45:
347:. Accumulating fluid in the interstitial space (interstitial edema) is caused by increased microvascular pressure and permeability, a positive feedback loop mechanism resulting in an associated in increasing the rate of microvascular filtration into the interstitial space. Decreased lymphatic drainage due to blockage can compound these effects. Interstitial edema can prevent oxygen diffusion across tissue and in the brain, kidney and intestines lead to the onset of compartment syndrome.
237:. The structure of the gel reticulum plays a role in the distribution of solutes across the interstitium, as the microstructure of the extracellular matrix in some parts excludes larger molecules (exclusion volume). The density of the collagen matrix fluctuates with the fluid volume of the interstitium. Increasing fluid volume is associated with a decrease in matrix fiber density, and a lower exclusion volume.
180:), serve a variety of structural and immune functions. Fibroblasts synthesize the production of structural molecules as well as enzymes that break down polymeric molecules. Such structural components exist both for the general interstitium of the body, and within individual organs, such as the myocardial interstitium of the
331:
refers to increased interstitial flow causing a neutral or reversed pressure differential between blood vessels and healthy tissue, limiting the distribution of intravenous drugs to tumors, which under other circumstances display a high-pressure gradient at their periphery.
200:
extend into the interstitium. The fluid spaces communicate with draining lymph nodes, although they do not have lining cells or structures of lymphatic channels. Interstitial fluid entering the lymphatic system becomes
195:
The interstitium in the submucosae of visceral organs, the dermis, superficial fascia, and perivascular adventitia are fluid-filled spaces supported by a collagen bundle lattice. Blind end, highly permeable, lymphatic
240:
The total fluid volume of the interstitium during health is about 20% of body weight, but this space is dynamic and may change in volume and composition during immune responses and in conditions such as
268:
interstitium facilitates solute and water transport between blood and urine in the vascular and tubular elements of the kidneys, and water reabsorption through changes in solute concentrations and
261:
and lungs to 21 to 24 mmHg in the liver, kidney and myocardium. Generally, increasing interstitial volume is associated with increased interstitial pressure and microvascular filtration.
678:
Benias, Petros C.; Wells, Rebecca G.; Sackey-Aboagye, Bridget; Klavan, Heather; Reidy, Jason; Buonocore, Darren; Miranda, Markus; Kornacki, Susan; Wayne, Michael (2018-03-27).
279:
The composition and chemical properties of the interstitial fluid vary among organs and undergo changes in chemical composition during normal function, as well as during
323:, the interstitial fluid and lymph system are sites where disease mechanisms may develop. Interstitial fluid flow is associated with the migration of cancer cells to
276:
associated with the spread of electrical events. The pulmonary interstitium allows for fluctuations in lung volume between inspiration and expiration.
424:
Wiig, H; Swartz, M. A (2012). "Interstitial fluid and lymph formation and transport: Physiological regulation and roles in inflammation and cancer".
328:
217:
The interstitial fluid is a reservoir and transportation system for nutrients and solutes distributing among organs, cells, and
335:
Changes in interstitial volume and pressure play critical roles in the onset of conditions like shock and inflammation. During
826:
477:
389:
382:
The interstitium and microvascular exchange. In: Handbook of
Physiology. The Cardiovascular System. Microcirculation
384:(sect. 2; pt. 1; chapt. 12; vol. IV ed.). Bethesda, MD: American Physiological Society. pp. 521–547.
1040:
156:-like reticulum. Collagen bundles of the extracellular matrix form scaffolding with a high tensile strength.
1045:
48:
Three-dimensional schematic of the interstitium, a fluid-filled space supported by a network of collagen
1050:
169:
157:
747:
205:, which is transported through lymphatic vessels until it empties into the microcirculation and the
339:, digestive enzymes and inflammatory agents diffuse to the interstitial space, then drain into the
257:. Interstitial fluid pressure is variable, ranging from -1 to -4 mmHg in tissues like the skin,
296:
258:
27:
577:"Changes in the myocardial interstitium and contribution to the progression of heart failure"
344:
691:
356:
109:
97:
8:
937:
Berggreen, E; Wiig, H (2014). "Lymphatic function and responses in periodontal disease".
361:
320:
308:
121:
695:
1007:
977:"Interstitial fluid flow in cancer: implications for disease progression and treatment"
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of organs. The role of the interstitium in solute concentration, protein transport and
81:
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In anatomy, a fluid-filled space between a structural barrier and internal structures
473:
The
Interstitium. In: Capillary Fluid Exchange: Regulation, Functions, and Pathology
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1002:
984:
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249:. The amount of interstitial fluid varies from about 50% of the tissue weight in
69:
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437:
764:
592:
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1029:
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680:"Structure and Distribution of an Unrecognized Interstitium in Human Tissues"
538:
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Matthes, Stephanie A.; Hadley, Ryan; Roman, Jesse; White, Eric S. (2015).
33:
646:
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Comparative
Biology of the Normal Lung Extracellular Matrix - Chapter 20
324:
280:
173:
161:
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340:
218:
197:
177:
165:
153:
60:
fluid-filled space existing between a structural barrier, such as a
880:
Haschek, Wanda M.; Rousseaux, Colin G.; Wallig, Matthew A. (2010),
230:
133:
288:
226:
137:
85:
805:
Moe, Orson W.; Giebisch, Gerhard H.; Seldin, Donald W. (2009),
748:"A Modern View of the Interstitial Space in Health and Disease"
677:
513:"A Modern View of the Interstitial Space in Health and Disease"
312:
265:
242:
185:
73:
469:
343:
lymphatic system and enter into circulation, contributing to
246:
202:
181:
113:
101:
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112:
impacts human pathology and physiological responses such as
250:
189:
65:
132:
The non-fluid parts of the interstitium are predominantly
96:
and supporting tissues within the body – called the
911:
476:. San Rafael, CA: Morgan & Claypool Life Sciences.
272:
gradients. The myocardial interstitium participates in
879:
635:
Clinical
Journal of the American Society of Nephrology
574:
92:
system. The interstitial compartment is composed of
847:Breshears, Melanie A.; Confer, Anthony W. (2017).
804:
1027:
379:
100:– that are situated outside the blood and
846:
628:
975:Munson, Jennifer; Shieh, Adrian (2014-08-01).
245:, and specifically within the interstitium of
936:
882:"Cardiovascular and Skeletal Muscle Systems"
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329:enhanced permeability and retention effects
470:Scallan J; Huxley VH; Korthuis RJ (2010).
423:
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600:
546:
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463:
461:
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188:, and the pulmonary interstitium of the
43:
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631:"Physiology of the Renal Interstitium"
452:
419:
417:
415:
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411:
409:
407:
405:
403:
401:
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886:Fundamentals of Toxicologic Pathology
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225:communicating between cells, and for
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504:
502:
500:
498:
496:
494:
80:. The fluid in this space is called
746:Stewart, Randolph H. (2020-11-05).
511:Stewart, Randolph H. (2020-11-05).
398:
373:
68:, and internal structures, such as
13:
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924:10.1016/b978-0-12-404577-4.00020-5
894:10.1016/b978-0-12-370469-6.00012-x
857:10.1016/b978-0-323-35775-3.00011-4
819:10.1016/b978-0-12-449851-8.00003-6
14:
1062:
851:. Elsevier. pp. 617–681.e1.
736:
491:
629:Zeisberg, M; Kalluri, R (2015).
575:Eckhouse SR; Spinale FG (2012).
184:, the renal interstitium of the
172:and inflammatory cells, such as
152:that are cross-linked to form a
930:
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840:
752:Frontiers in Veterinary Science
517:Frontiers in Veterinary Science
480:from the original on 2021-02-08
981:Cancer Management and Research
918:. Elsevier. pp. 387–402.
888:, Elsevier, pp. 319–376,
811:Genetic Diseases of the Kidney
798:
1:
367:
813:, Elsevier, pp. 39–73,
212:
127:
7:
951:10.1016/j.yexcr.2013.12.006
380:Bert JL; Pearce RH (1984).
350:
170:interstitial cells of Cajal
10:
1067:
939:Experimental Cell Research
704:10.1038/s41598-018-23062-6
438:10.1152/physrev.00037.2011
302:
765:10.3389/fvets.2020.609583
593:10.1016/j.hfc.2011.08.012
530:10.3389/fvets.2020.609583
26:
21:
297:chronic kidney disease
88:, and drains into the
84:, comprises water and
49:
28:Anatomical terminology
807:"Logic of the Kidney"
426:Physiological Reviews
345:systemic inflammation
287:, and development of
136:types I, III, and V,
47:
1041:Extracellular matrix
647:10.2215/CJN.00640114
357:Extracellular matrix
110:hydrostatic pressure
98:extracellular matrix
990:10.2147/CMAR.S65444
696:2018NatSR...8.4947B
362:Extracellular fluid
321:periodontal disease
223:signaling molecules
164:, dendritic cells,
1046:Matrices (biology)
849:The Urinary System
684:Scientific Reports
315:, kidney disease,
158:Interstitial cells
142:glycosaminoglycans
82:interstitial fluid
78:circulatory system
50:
1051:Tissues (biology)
828:978-0-12-449851-8
641:(10): 1831–1840.
337:hypovolemic shock
311:, heart disease,
235:immune regulation
233:participating in
102:lymphatic vessels
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281:body growth
270:hydrostatic
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198:capillaries
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1030:Categories
899:2024-04-22
834:2024-04-22
484:2018-03-29
368:References
341:mesenteric
325:metastatic
178:mast cells
166:adipocytes
146:hyaluronan
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289:diseases
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