128:, a bacterium that can survive several different extreme conditions. In 2001, Koonin hired Makarova to join him at NCBI. At the center, beginning in 2006, Makarova and her co-workers investigated the CRISPR-Cas9 system and its biological function as a bacterial
119:
310:
Anzalone, Andrew V.; Koblan, Luke W.; Liu, David R. (2020). "Genome editing with CRISPR–Cas nucleases, base editors, transposases and prime editors".
66:, and competed at the national level in the Soviet Biology Olympiad. After completing high school she tried unsuccessfully for several years to enter
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to be closer to her husband's family. There, the shortages of laboratory supplies led her to work in
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132:. Interest in the system heightened after other researchers subsequently used it to perform
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Zetsche, Bernd; Gootenberg, Jonathan S.; Abudayyeh, Omar O.; Slaymaker, Ian M.;
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in
Novosibirsk. Her work at the institute involved the design of synthetic
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167:"Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System"
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NLM in Focus: A look inside the US National
Library of Medicine
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118:, Koonin found Makarova a position as research fellow at the
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386:"Focus on NLM Scientists: Dr. Kira Makarova Makes Her Mark"
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When
Makarova's husband moved to the US to work with
74:, but after marrying and having a child she moved to
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Uniformed
Services University of the Health Sciences
237:"The CRISPR tool kit for genome editing and beyond"
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416:, National Center for Biotechnology Information
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44:National Center for Biotechnology Information
143:, and the genetics and protein functions of
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34:known for her research on the biology of
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139:Makarova's ongoing research involves
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438:, Broad Institute, 25 September 2015
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569:Novosibirsk State University alumni
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384:McKay, Kathryn (January 8, 2018),
84:Institute of Cytology and Genetics
42:. She is a staff scientist at the
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579:American evolutionary biologists
539:21st-century American biologists
534:20th-century American biologists
16:American evolutionary biologist
584:Women computational biologists
392:, National Library of Medicine
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589:Women evolutionary biologists
473:(1–2), Elsevier {BV}: 18–28,
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94:and, separately, the use of
76:Novosibirsk State University
7:
98:frequency data to classify
88:Russian Academy of Sciences
10:
605:
480:10.1016/j.cell.2015.12.041
268:10.1038/s41467-018-04252-2
190:10.1016/j.cell.2015.09.038
70:. She instead entered the
544:American women biologists
330:10.1038/s41587-020-0561-9
106:Later career and research
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574:Computational biologists
507:publications indexed by
72:Moscow Medical Institute
50:Early life and education
554:Soviet women biologists
410:"Kira S. Makarova, PhD"
125:Deinococcus radiodurans
68:Moscow State University
460:"The Heroes of CRISPR"
165:; Zhang, Feng (2015).
32:evolutionary biologist
242:Nature Communications
235:Adli, Mazhar (2018).
80:computational biology
313:Nature Biotechnology
151:Notable publications
141:comparative genomics
54:Makarova grew up in
259:2018NatCo...9.1911A
58:, then part of the
529:Soviet biologists
163:Koonin, Eugene V.
159:Makarova, Kira S.
30:) is an American
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458:(January 2016),
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92:oligonucleotides
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62:and later in
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96:oligopeptide
60:Soviet Union
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324:: 824–844.
231:– Cited by
183:: 759–771.
122:, studying
518:Categories
442:2019-09-23
420:2019-09-23
396:2019-09-23
366:References
181:Cell Press
338:1087-0156
277:2041-1723
199:0092-8674
489:26771483
354:21692417
346:32572269
303:21692417
295:29765029
253:: 1911.
217:26422227
100:proteins
286:5953931
255:Bibcode
225:3628765
208:4638220
145:archaea
114:in the
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64:Estonia
24:Russian
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36:CRISPR
463:(PDF)
350:S2CID
320:(7).
299:S2CID
249:(1).
221:S2CID
179:(3).
56:Narva
485:PMID
467:Cell
342:PMID
334:ISSN
291:PMID
273:ISSN
213:PMID
195:ISSN
172:Cell
40:Cas9
38:and
475:doi
471:164
326:doi
281:PMC
263:doi
203:PMC
185:doi
177:163
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