86:(LIBD) is a nonprofit research center located in Baltimore, Maryland, that studies brain development issues such as schizophrenia and autism. The cause of most neuropsychiatric disorders remains unknown and current therapies such as antipsychotics and antidepressants treat symptoms rather than the underlying illness. Lieber is working to unravel the biological basis of these brain disorders and is developing therapies to treat or prevent their development.
22:
144:
because
African Americans are 20% more likely to experience serious mental health problems than the general population and are about twice as likely to develop Alzheimer’s disease. Suicide rates for African American children aged 5–11 are twice as high as comparable individuals of European ancestry even after controlling for socioeconomic factors. In the summer of 2020, Governor
143:
The
African Ancestry Neuroscience Research Initiative will generate brain gene and protein expression profiles for people of African ancestry, a group that is greatly underrepresented in research examining the genetic causes of diseases. Lack of research involving African Americans is problematic
135:
In 2019, the Lieber
Institute announced a new initiative to study brain diseases in African Americans. The venture is a partnership with the African-American Clergy Medical Research Initiative, a group of clergy leaders in Baltimore. Research suggests that neuropsychiatric diagnoses are 20% more
111:
In a
December 2015 paper in Neuron, the Lieber Institute announced the formation of a new consortium called BrainSeq, along with seven pharmaceutical partners. The consortium’s goal is to analyze post mortem brain samples for DNA, RNA and DNA-methylation differences establish a public database.
107:
In 2011, researchers who later joined the Lieber
Institute published a review of brain banks for studying diseases such as schizophrenia, alzheimer’s diseases, bipolar disorder, and other psychiatric illnesses. Postmortem human brain tissue is critical for advancing neurobiological studies of
98:
is the CEO. Having gathered over 3,000 brains for research purposes, the institute has the largest collection of post-mortem brains diagnosed with post-traumatic stress disorder. These brains are used to study the biological basis for mental illnesses. In one study of post-mortem brains, LIBD
126:
that examined the placenta and found that genes and pregnancy problems combine to increase the likelihood of developing schizophrenia. This study adds to growing evidence that the placenta is critical to understanding the health and course of pregnancy.
507:
Rannals, Matthew D; Hamersky, Gregory R; Page, Stephanie Cerceo; Campbell, Morganne N; Briley, Aaron; Gallo, Ryan A; Phan, Badoi N; Hyde, Thomas M; Kleinman, Joel E; Shin, Joo Heon; Jaffe, Andrew E; Weinberger, Daniel R; Maher, Brady J (2016).
202:
136:
frequent in
African-American communities than in communities of European ancestry. In studies of brain disorders, individuals of African descent make up, on average, less than 5% of research cohorts. Lieber Institute Director
99:
researchers found that patients with schizophrenia had high levels of DNA methylation in brain regions associated with risk for schizophrenia. They are also developing a drug to prevent post-traumatic stress disorder.
725:
148:
of
Maryland budgeted $ 1.25 million to the effort, with another $ 1 million coming from Brown Capital, one of the oldest African-American founded asset management firms in the country.
632:
The
Placenta, an Afterthought No Longer An ephemeral organ, long dismissed merely as afterbirth, increasingly is viewed as critical to understanding the health and course of pregnancy.
835:
791:
612:
94:
The Lieber
Institute was started in 2010 by Steve and Connie Lieber along with Milton and Tamar Maltz—both families have children with schizophrenia. Psychiatrist
173:
115:
A paper by Lieber scientists found that altering brain proteins caused the cells of autistic brains to behave normally. The specific type of autism is called
353:
244:"Constance E. Lieber Receives 2017 Honorary Pardes Humanitarian Prize in Mental Health for Extraordinary Advocacy and Support of Psychiatric Research"
830:
76:
597:
740:
268:
42:
510:"Psychiatric Risk Gene Transcription Factor 4 Regulates Intrinsic Excitability of Prefrontal Neurons via Repression of SCN10a and KCNQ1"
661:
334:
572:
243:
755:
119:
and researchers are looking into possible treatments that could be used for the condition and for other types of autism.
556:
60:
741:
Morgan
Eichensehr, Maryland, Brown Capital put $ 2.25M toward the initiative to close racial gaps in neuroscience.
391:
38:
410:
779:
662:
Daniel R. Weinberger, Alvin C. Hathaway Sr. Research will support personalized medicine for African Americans.
31:
631:
156:
LIBD established a champions council of celebrities to mobilize awareness of the need for brain research.
116:
613:
Kiera Butler. Researchers Just Made a Disturbing Discovery About Your Child’s Schizophrenia Risk.
557:
Meredith Cohn. Lieber scientists discover how rare form of autism works and a possible treatment.
140:
wrote that individuals of African ancestry must be included in research for brain illnesses.
297:
137:
95:
8:
174:"New Brain Research Institute Chooses Home In Johns Hopkins Bioscience Park - 06/07/2010"
460:"BrainSeq: Neurogenomics to Drive Novel Target Discovery for Neuropsychiatric Disorders"
301:
703:
678:
647:
Jennifer Couzin-Frankel. New effort aims to study brain diseases in African-Americans.
627:
534:
509:
489:
435:
411:"Psychiatric Brain Banking: Three Perspectives on Current Trends and Future Directions"
203:"Dissecting brains to find the biological answers to the mysteries of mental disorders"
708:
539:
481:
440:
315:
698:
690:
529:
521:
493:
471:
430:
426:
422:
305:
225:
694:
525:
476:
459:
37:
It may require cleanup to comply with Knowledge's content policies, particularly
598:
Dana G. Smith. The Placenta Is Now a Suspect In Heightening Schizophrenia Risk.
824:
806:
793:
646:
372:
712:
543:
485:
444:
319:
726:
Daniel R. Weinberger, Missing in Action: African Ancestry Brain Research.
354:"Business and the brain: How some scientists hope to cure mental illness"
145:
269:
Scott Dance. Lieber Institute expanding at Johns Hopkins research park.
77:
United States Military Academy § Research centers and institutes
310:
285:
130:
229:
783:
573:"Maher Lab Identifies Potential Drug Targets for Pitt Hopkins"
506:
220:"Inside View: The Lieber Institute for Brain Development".
772:
373:"Schizophrenia Tied to Epigenetic Changes Before Birth"
335:"Inside the World's Largest Collection of PTSD Brains"
30:
A major contributor to this article appears to have a
756:
Institute for Brain Development, 2019 Annual Report.
679:"Missing in Action: African Ancestry Brain Research"
196:
194:
836:Neuroscience research centers in the United States
191:
131:African Ancestry Neuroscience Research Initiative
822:
75:For Lieber Institute for Law & Warfare, see
392:"New drug could prevent PTSD in trauma victims"
408:
122:Researchers with Lieber published a paper in
102:
676:
89:
702:
533:
475:
434:
309:
151:
61:Learn how and when to remove this message
457:
248:Brain & Behavior Research Foundation
831:Medical research institutes in Maryland
823:
389:
370:
332:
286:"A radical approach to mental illness"
283:
200:
84:Lieber Institute for Brain Development
390:Walker, Heather (February 21, 2017).
15:
351:
13:
371:Brooks, Megan (December 4, 2015).
333:Mullin, Emily (October 14, 2016).
14:
847:
764:
352:May, Kathryn (January 12, 2015).
41:. Please discuss further on the
20:
749:
734:
719:
670:
655:
640:
621:
606:
591:
565:
550:
500:
451:
402:
383:
201:Mullin, Emily (April 8, 2019).
427:10.1016/j.biopsych.2010.05.025
364:
345:
326:
277:
262:
236:
213:
166:
1:
159:
695:10.1016/j.neuron.2020.07.008
526:10.1016/j.neuron.2016.02.021
477:10.1016/j.neuron.2015.10.047
458:Schubert, Christian (2015).
7:
677:Weinberger, Daniel (2020).
409:Deep-Soboslay, Amy (2011).
10:
852:
743:Baltimore Business Journal
74:
103:Research and partnerships
780:Lieber Institute studies
284:Abbott, Alison (2011).
178:www.hopkinsmedicine.org
90:History and description
152:LIBD Champions Council
108:psychiatric illness.
807:39.30014°N 76.59062°W
415:Biological Psychiatry
339:MIT Technology Review
117:Pitt–Hopkins syndrome
39:neutral point of view
250:. September 13, 2017
138:Daniel R. Weinberger
96:Daniel R. Weinberger
812:39.30014; -76.59062
803: /
636:, December 3, 2018.
600:Scientific American
302:2011Natur.477..146A
628:Apoorva Mandavilli
666:, March 21, 2019.
651:, March 22, 2019.
561:, March 11, 2016.
559:The Baltimore Sun
271:The Baltimore Sun
71:
70:
63:
34:with its subject.
843:
818:
817:
815:
814:
813:
808:
804:
801:
800:
799:
796:
776:
775:
773:Official website
758:
753:
747:
745:, July 23, 2020.
738:
732:
723:
717:
716:
706:
674:
668:
659:
653:
644:
638:
625:
619:
610:
604:
595:
589:
588:
586:
584:
579:. March 11, 2016
569:
563:
554:
548:
547:
537:
504:
498:
497:
479:
470:(6): 1078–1083.
455:
449:
448:
438:
406:
400:
399:
396:WoodTV Channel 8
387:
381:
380:
368:
362:
361:
349:
343:
342:
330:
324:
323:
313:
281:
275:
273:, July 20, 2013.
266:
260:
259:
257:
255:
240:
234:
233:
217:
211:
210:
198:
189:
188:
186:
184:
170:
66:
59:
55:
52:
46:
32:close connection
24:
23:
16:
851:
850:
846:
845:
844:
842:
841:
840:
821:
820:
811:
809:
805:
802:
797:
794:
792:
790:
789:
771:
770:
767:
762:
761:
754:
750:
739:
735:
730:,July 24, 2020.
724:
720:
675:
671:
660:
656:
645:
641:
626:
622:
617:, May 31, 2018.
611:
607:
602:, May 28, 2018.
596:
592:
582:
580:
577:pitthopkins.org
571:
570:
566:
555:
551:
505:
501:
456:
452:
407:
403:
388:
384:
369:
365:
350:
346:
331:
327:
311:10.1038/477146a
282:
278:
267:
263:
253:
251:
242:
241:
237:
219:
218:
214:
207:Washington Post
199:
192:
182:
180:
172:
171:
167:
162:
154:
133:
124:Nature Medicine
105:
92:
80:
67:
56:
50:
47:
36:
25:
21:
12:
11:
5:
849:
839:
838:
833:
787:
786:
777:
766:
765:External links
763:
760:
759:
748:
733:
718:
689:(3): 407–411.
669:
654:
639:
634:New York Times
620:
605:
590:
564:
549:
499:
450:
421:(2): 104–112.
401:
382:
363:
358:Financial Post
344:
325:
276:
261:
235:
230:10.1038/nj0496
212:
190:
164:
163:
161:
158:
153:
150:
132:
129:
104:
101:
91:
88:
69:
68:
28:
26:
19:
9:
6:
4:
3:
2:
848:
837:
834:
832:
829:
828:
826:
819:
816:
785:
781:
778:
774:
769:
768:
757:
752:
746:
744:
737:
731:
729:
722:
714:
710:
705:
700:
696:
692:
688:
684:
680:
673:
667:
665:
664:Baltimore Sun
658:
652:
650:
643:
637:
635:
629:
624:
618:
616:
609:
603:
601:
594:
578:
574:
568:
562:
560:
553:
545:
541:
536:
531:
527:
523:
519:
515:
511:
503:
495:
491:
487:
483:
478:
473:
469:
465:
461:
454:
446:
442:
437:
432:
428:
424:
420:
416:
412:
405:
397:
393:
386:
378:
374:
367:
359:
355:
348:
340:
336:
329:
321:
317:
312:
307:
303:
299:
296:(7363): 146.
295:
291:
287:
280:
274:
272:
265:
249:
245:
239:
231:
227:
223:
216:
208:
204:
197:
195:
179:
175:
169:
165:
157:
149:
147:
141:
139:
128:
125:
120:
118:
113:
109:
100:
97:
87:
85:
78:
73:
65:
62:
54:
51:November 2018
44:
40:
35:
33:
27:
18:
17:
788:
751:
742:
736:
727:
721:
686:
682:
672:
663:
657:
648:
642:
633:
623:
615:Mother Jones
614:
608:
599:
593:
581:. Retrieved
576:
567:
558:
552:
520:(1): 43–55.
517:
513:
502:
467:
463:
453:
418:
414:
404:
395:
385:
376:
366:
357:
347:
338:
328:
293:
289:
279:
270:
264:
252:. Retrieved
247:
238:
221:
215:
206:
181:. Retrieved
177:
168:
155:
142:
134:
123:
121:
114:
110:
106:
93:
83:
81:
72:
57:
48:
29:
810: /
222:Nature Jobs
146:Larry Hogan
825:Categories
798:76°35′26″W
795:39°18′01″N
160:References
583:April 23,
254:April 23,
183:April 23,
43:talk page
713:32710819
544:26971948
486:26687217
445:20673875
377:MedScape
320:21900988
224:. 2016.
704:7380218
649:Science
535:4824652
494:4912682
436:3105380
298:Bibcode
784:PubMed
728:Neuron
711:
701:
683:Neuron
542:
532:
514:Neuron
492:
484:
464:Neuron
443:
433:
318:
290:Nature
490:S2CID
709:PMID
585:2019
540:PMID
482:PMID
441:PMID
316:PMID
256:2019
185:2019
82:The
782:on
699:PMC
691:doi
687:107
530:PMC
522:doi
472:doi
431:PMC
423:doi
306:doi
294:477
226:doi
827::
707:.
697:.
685:.
681:.
630:.
575:.
538:.
528:.
518:90
516:.
512:.
488:.
480:.
468:88
466:.
462:.
439:.
429:.
419:69
417:.
413:.
394:.
375:.
356:.
337:.
314:.
304:.
292:.
288:.
246:.
205:.
193:^
176:.
715:.
693::
587:.
546:.
524::
496:.
474::
447:.
425::
398:.
379:.
360:.
341:.
322:.
308::
300::
258:.
232:.
228::
209:.
187:.
79:.
64:)
58:(
53:)
49:(
45:.
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.