44:
470:
binding to DNA. These trigger sexual development by the association of A proteins with different homeodomains sequences (HD1 and HD2). A factors contain several duplicate genes coding for the A protein but it is only necessary for any one of these genes to be allelic unmatched to trigger the whole
449:
ending in sexual reproduction are all controlled by a positive stimulus triggered by the meeting of unlike alleles of the A and B factors. This is in contrast to the oppositional inhibition of the final stages of sexual reproduction by the meeting of like alleles in flowering plants. Using elegant
342:
Casselton was a Fellow of St Cross
College Oxford from 1993 to 2003, and was appointed Professor of Fungal Genetics at Oxford in 1997. Her specialism was sexual development in fungi and she contributed to over 100 publications on this topic. She was a Fellow of
1461:
1541:
1545:
1465:
351:, from 2000. She was a member of the Royal Society's Council from 2002 to 2003, and rejoined the Council in 2006 as Vice-President and Foreign Secretary, replacing Professor Dame
815:"The combination of dissimilar alleles of the A-alpha and A-beta gene complexes, whose proteins contain homeo domain motifs, determines sexual development in the mushroom
1964:
1929:
1066:
336:
332:
1904:
378:
She married Peter John
Casselton in 1961, divorcing him in 1978. She married William Joseph Dennis Tollett in 1981. She died after a short illness, aged 75.
475:
found in mammalian cells suggest that helical regions adjacent to the homeodomain may discriminate between compatible and incompatible protein associations.
1594:
1029:
264:
299:
and her father's interest in natural history and genetics encouraged her and her sister
Pauline in the direction of biology. She was educated at
1909:
1899:
747:"An N-terminal dimerization domain permits homeodomain proteins to choose compatible partners and initiate sexual development in the mushroom
1954:
1944:
1914:
1483:
1316:
359:
491:"Insights into evolution of multicellular fungi from the assembled chromosomes of the mushroom Coprinopsis cinerea (Coprinus cinereus)"
1894:
328:
1959:
1949:
1974:
1404:
197:
1939:
1577:
1508:
311:, from which she gained a Bachelor of Science (BSc) degree in botany and a Doctor of Philosophy (PhD) degree in 1964.
1924:
899:
Sealy-Lewis, HM.; Casselton, LA. (1978). "Restoration of enzyme activity by recessive missense suppressors in fungus
1063:
1095:
Who's Who 2014, A & C Black, an imprint of
Bloomsbury Publishing plc, 2014; online edn, Oxford University Press
363:
324:
181:
1816:
1732:
300:
661:"A constitutively active G-protein-coupled receptor causes mating self-compatibility in the mushroom Coprinus"
1969:
348:
1934:
1794:
630:
Brown, AJ; Casselton, LA. (2001). "Mating in mushrooms: increasing the chances but prolonging the affair".
1919:
1784:
1586:
403:
251:
247:
152:
140:
33:
29:
1979:
1811:
1767:
410:
for services to fungal genetics and international science. Her nomination for the Royal
Society reads:
1374:
1757:
399:
308:
102:
1705:
344:
1356:
1340:
792:
Kues, U.; Casselton, LA. (1992). "Fungal mating type genes - regulators of sexual development".
1570:
1555:
1521:
1487:
320:
542:
Riquelme, Meritxell; Challen, Michael P.; Casselton, Lorna A.; Brown, Andrew J. (6 May 2005).
1090:
407:
1889:
1884:
1633:
472:
268:
176:
8:
1847:
1423:
Shahriari, H.; Casselton, L. A. (1974). "Suppression of methionine mutants in
Coprinus".
451:
279:
1526:
1440:
1046:
928:
873:
685:
660:
578:
543:
525:
490:
256:
882:
853:
805:
775:
746:
643:
1563:
1296:
1252:
1207:
1145:
1140:
1115:
998:
920:
887:
840:
780:
733:
728:
703:
690:
647:
618:
583:
565:
530:
512:
419:
395:
391:
273:
146:
1444:
1050:
1789:
1727:
1608:
1432:
1286:
1242:
1231:"Missense suppression in Coprinus lagopus associated with a chromosome duplication"
1197:
1135:
1127:
1038:
988:
957:
932:
912:
877:
869:
830:
801:
770:
762:
723:
715:
680:
672:
639:
608:
573:
555:
520:
502:
467:
415:
295:, Essex to William Charles Henry Smith and Cecile Smith (nÊe Bowman). Her parents'
209:
1167:
1618:
1613:
1131:
1070:
719:
430:
319:
Casselton began her career in lecturing and research as an assistant lecturer at
227:
560:
489:
Stajich, J. E.; Wilke, S. K.; Ahren, D.; Au, C. H.; et al. (14 June 2010).
370:, travelling to 27 different countries during three and a half years in office.
255:(18 July 1938 â 14 February 2014) was a British academic and biologist. She was
1842:
1779:
1752:
1717:
1690:
1680:
1675:
1650:
1628:
1542:"EC/1999/07: Casselton, Lorna Ann. Royal Society Library and Archive Catalogue"
676:
304:
1291:
1274:
1202:
1185:
993:
972:
962:
941:
1878:
1857:
1852:
1742:
1670:
1665:
1590:
1247:
1230:
1171:
569:
516:
387:
352:
1341:
Lorna
Casselton obituary: Researcher into the genetic basis of fungal mating
507:
479:
The
British Mycological Society awarded her an Honorary Membership in 2002.
43:
1863:
1837:
1821:
1806:
1747:
1685:
1660:
1623:
1360:
1321:
1211:
1042:
1002:
784:
694:
651:
622:
613:
596:
587:
534:
442:
296:
1800:
1773:
1711:
1644:
1300:
1256:
1149:
1027:; Jones, D. A. (2012). "Dan Lewis. 30 December 1910 â 30 September 2009".
891:
844:
737:
1762:
1737:
1722:
1655:
455:
450:
genetic and molecular techniques with different genetic stocks including
924:
835:
814:
766:
1436:
916:
271:, and was known for her genetic and molecular analysis of the mushroom
1406:
The production, behaviour and genetics of diploids of
Coprinus lagopus
198:
The production, behaviour and genetics of diploids of
Coprinus lagopus
1700:
1695:
459:
852:
Binninger, DM.; Skrzynia, C.; Pukkila, PJ.; Casselton, LA. (1987).
446:
423:
292:
260:
71:
1116:"Molecular genetics of mating recognition in basidiomycete fungi"
851:
704:"Molecular genetics of mating recognition in basidiomycete fungi"
544:"The Origin of MultipleBMating Specificities inCoprinus cinereus"
1585:
659:
Olesnicky, NS.; Brown, AJ.; Dowell, SJ.; Casselton, LA. (1999).
463:
434:
191:
90:
1186:"The production and behaviour of diploids of Coprinus lagopus"
358:
As Foreign Secretary of the Royal Society, Casselton gave the
1275:"Compatibility and stability of diploids in Coprinus lagopus"
658:
541:
438:
367:
942:"Dilution of gene products in cytoplasm of heterokaryons in
744:
398:
by Queen Mary College, University of London in 2009 and
1511:
Megan Palmer, 18 February 2014. Retrieved 23 June 2015.
812:
745:
Banham, AH.; Asanteowusu, RN.; Casselton, LA. (1995).
437:
which she used to demonstrate for the first time that
1091:"CASSELTON, Prof. Lorna Ann, (Mrs W. J. D. Tollett)"
1030:
Biographical Memoirs of Fellows of the Royal Society
898:
471:
sexual development. Other domains characteristic of
1462:"Plant Sciences Staff Professor Lorna A. Casselton"
488:
1422:
1110:
854:"DNA-mediated transformation of the basidiomycete
813:Kues, U.; Richardson, WVJ; Casselton, LA. (1992).
701:
1965:People educated at Southend High School for Girls
1876:
1477:
1475:
1168:http://royalsociety.org/people/lorna-casselton/
554:(3). Oxford University Press (OUP): 1105â1119.
495:Proceedings of the National Academy of Sciences
347:, from 1993 to 2003, and an Honorary Fellow of
1269:
1224:
1023:
939:
629:
1930:Commanders of the Order of the British Empire
1571:
791:
1905:Academics of Queen Mary University of London
1472:
1367:
404:Commander of the Order of the British Empire
323:in London. She was Professor of Genetics at
1544:. London: The Royal Society. Archived from
1486:. University College London. Archived from
1336:
1334:
1332:
1330:
327:from 1989 to 1991 and was later awarded an
112:Genetic and molecular analysis of mushrooms
1578:
1564:
1312:
1310:
1120:Microbiology and Molecular Biology Reviews
708:Microbiology and Molecular Biology Reviews
42:
1456:
1454:
1399:
1290:
1246:
1201:
1183:
1139:
1085:
1083:
1081:
1079:
992:
973:"Production and behaviour of diploids of
970:
961:
881:
834:
774:
727:
684:
612:
594:
577:
559:
524:
506:
16:British geneticist, academic and educator
1520:
1409:(PhD thesis). University College London.
1364:, 31 March 2014. Retrieved 23 June 2015.
1327:
482:
1307:
1017:
702:Casselton, LA.; Olesnicky, NS. (1998).
458:, she has shown that the A factor is a
429:, in particular of the incompatibility
335:Postdoctoral Fellowship, followed by a
126:William Joseph Dennis Tollett (m. 1981)
1877:
1530:(Supplement). 16 June 2012. p. 7.
1451:
1076:
291:Casselton was born on 18 July 1938 in
1910:Academics of the University of Oxford
1900:20th-century British women scientists
1559:
1534:
402:in September 2010. She was appointed
394:in 2008, and was awarded an Honorary
381:
1425:MGG Molecular & General Genetics
1163:
1161:
1159:
390:in 1999. She became a Member of the
339:Senior Research Fellowship in 1995.
1955:Female fellows of the Royal Society
1945:Fellows of St Cross College, Oxford
1915:Alumni of University College London
1393:
307:in Southend-on-Sea. She studied at
13:
940:Casselton, LA.; Lewis, D. (1967).
874:10.1002/j.1460-2075.1987.tb04828.x
314:
14:
1991:
1481:
1156:
1064:Professor Lorna Casselton CBE FRS
386:She was elected a Fellow of the
373:
360:Royal Society Rutherford Lecture
1895:20th-century British biologists
1514:
1502:
1416:
1350:
1235:Journal of General Microbiology
325:Queen Mary University of London
182:Queen Mary University of London
123:Peter John Casselton (d. 1978);
1263:
1218:
1177:
1104:
1057:
905:Molecular and General Genetics
301:Southend High School for Girls
1:
1170:Casselton's biography on the
1010:
806:10.1016/s0953-7562(09)80107-x
644:10.1016/s0168-9525(01)02343-5
466:genes encoding proteins with
286:
1960:Members of Academia Europaea
1950:Fellows of the Royal Society
1132:10.1128/mmbr.62.1.55-70.1998
720:10.1128/mmbr.62.1.55-70.1998
7:
1975:People from Southend-on-Sea
1484:"Honorary Graduates of UCL"
1375:"Professor Lorna Casselton"
1114:; Olesnicky, N. S. (1998).
1073:, University College London
597:"Mate recognition in fungi"
561:10.1534/genetics.105.040774
265:Department of Plant Science
10:
1996:
349:St Hilda's College, Oxford
1940:British women geneticists
1830:
1601:
1292:10.1017/s0016672300009915
1203:10.1017/S0016672300004080
1184:Casselton, L. A. (2009).
994:10.1017/s0016672300004080
963:10.1017/s0016672300010314
400:University College London
309:University College London
222:
218:
208:
190:
169:
162:
133:
116:
108:
103:University College London
98:
79:
53:
41:
23:
1925:British women biologists
1801:Graham Barry Warren
1509:St Cross College, Oxford
1357:Lorna Casselton obituary
1248:10.1099/00221287-88-1-20
677:10.1093/emboj/18.10.2756
362:in South Africa and the
345:St Cross College, Oxford
1412:(subscription required)
1100:(subscription required)
971:Casselton, LA. (1965).
823:Genes & Development
595:Casselton, LA. (2002).
508:10.1073/pnas.1003391107
1817:Robert Williamson
1812:Peter M. Williams
1733:John G. McWhirter
1043:10.1098/rsbm.2011.0023
614:10.1038/sj.hdy.6800035
477:
414:Distinguished for her
321:Royal Holloway College
1758:John G. Shepherd
1645:John Brian Clegg
483:Selected publications
473:transcription factors
445:, the formation of a
412:
408:2012 Birthday Honours
1970:People from Rochford
1774:Alfred G. Sykes
1712:John Paul Maier
1706:Peter L. Knight
1273:; Lewis, D. (1966).
1069:5 March 2016 at the
794:Mycological Research
433:, A and B. She made
269:University of Oxford
177:University of Oxford
1935:English geneticists
1848:G. Ledyard Stebbins
1785:John F. Toland
1768:James Stirling
1634:Ian Carmichael
1317:Casselton's profile
836:10.1101/gad.6.4.568
767:10.1105/tpc.7.6.773
501:(26): 11889â11894.
431:mating type factors
243:Lorna Ann Casselton
1920:British biologists
1671:Athene Donald
1527:The London Gazette
1437:10.1007/BF00332815
1279:Genetical Research
1190:Genetical Research
981:Genetical Research
950:Genetical Research
917:10.1007/bf00267386
632:Trends in Genetics
420:molecular analysis
382:Awards and honours
257:Professor Emeritus
48:Casselton in 2010.
1980:People from Essex
1872:
1871:
1838:Robert Huber
1822:Magdi Yacoub
1490:on 12 August 2016
856:Coprinus cinereus
817:Coprinus cinereus
749:Coprinus cinereus
671:(10): 2756â2763.
443:nuclear migration
427:Coprinus cinereus
396:Doctor of Science
392:Academia Europaea
274:Coprinus cinereus
240:
239:
164:Scientific career
1987:
1795:Alan Walker
1728:Ernest McCulloch
1723:Iain Mattaj
1609:Frances Ashcroft
1580:
1573:
1566:
1557:
1556:
1550:
1549:
1548:on 2 April 2014.
1538:
1532:
1531:
1518:
1512:
1506:
1500:
1499:
1497:
1495:
1479:
1470:
1469:
1468:on 1 March 2012.
1464:. Archived from
1458:
1449:
1448:
1420:
1414:
1413:
1410:
1401:Casselton, Lorna
1397:
1391:
1390:
1388:
1386:
1371:
1365:
1354:
1348:
1338:
1325:
1314:
1305:
1304:
1294:
1271:Casselton, L. A.
1267:
1261:
1260:
1250:
1227:Casselton, L. A.
1222:
1216:
1215:
1205:
1181:
1175:
1165:
1154:
1153:
1143:
1112:Casselton, L. A.
1108:
1102:
1101:
1098:
1087:
1074:
1061:
1055:
1054:
1025:Casselton, L. A.
1021:
1006:
996:
975:Coprinus lagopus
967:
965:
944:Coprinus lagopus
936:
895:
885:
848:
838:
809:
800:(12): 993â1006.
788:
778:
741:
731:
698:
688:
655:
626:
616:
591:
581:
563:
538:
528:
510:
280:Coprinus lagopus
254:
236:
234:/lorna-casselton
233:
231:
229:
210:Doctoral advisor
204:
86:
83:14 February 2014
74:, Essex, England
67:
65:
46:
36:
21:
20:
1995:
1994:
1990:
1989:
1988:
1986:
1985:
1984:
1875:
1874:
1873:
1868:
1826:
1639:Lorna Casselton
1619:Rosa Beddington
1614:Anthony Barrett
1597:
1584:
1554:
1553:
1540:
1539:
1535:
1519:
1515:
1507:
1503:
1493:
1491:
1480:
1473:
1460:
1459:
1452:
1421:
1417:
1411:
1398:
1394:
1384:
1382:
1381:. 27 March 2014
1373:
1372:
1368:
1355:
1351:
1347:, 31 March 2014
1339:
1328:
1315:
1308:
1268:
1264:
1223:
1219:
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1178:
1166:
1157:
1109:
1105:
1099:
1089:
1088:
1077:
1071:Wayback Machine
1062:
1058:
1022:
1018:
1013:
485:
384:
376:
317:
315:Academic career
289:
246:
226:
202:
186:
158:
129:
99:Alma mater
94:
88:
84:
75:
69:
63:
61:
60:
59:
58:Lorna Ann Smith
49:
37:
28:
26:
25:Lorna Casselton
17:
12:
11:
5:
1993:
1983:
1982:
1977:
1972:
1967:
1962:
1957:
1952:
1947:
1942:
1937:
1932:
1927:
1922:
1917:
1912:
1907:
1902:
1897:
1892:
1887:
1870:
1869:
1867:
1866:
1861:
1855:
1850:
1845:
1843:Marc Kirschner
1840:
1834:
1832:
1828:
1827:
1825:
1824:
1819:
1814:
1809:
1804:
1797:
1792:
1787:
1782:
1780:Janet Thornton
1777:
1770:
1765:
1760:
1755:
1753:Dolph Schluter
1750:
1745:
1740:
1735:
1730:
1725:
1720:
1718:Barry Marshall
1715:
1708:
1703:
1698:
1693:
1691:Timothy Gowers
1688:
1683:
1681:Douglas Fearon
1678:
1676:Philip England
1673:
1668:
1663:
1658:
1653:
1651:David Cockayne
1648:
1641:
1636:
1631:
1629:Simon Campbell
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1415:
1392:
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1349:
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1262:
1217:
1196:(2): 190â208.
1176:
1155:
1103:
1075:
1056:
1015:
1014:
1012:
1009:
1008:
1007:
987:(2): 190â208.
968:
937:
911:(2): 211â215.
896:
868:(4): 835â840.
849:
829:(4): 568â577.
810:
789:
761:(6): 773â783.
742:
699:
656:
638:(7): 393â400.
627:
607:(2): 142â147.
592:
539:
484:
481:
452:gene deletions
383:
380:
375:
372:
316:
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305:grammar school
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109:Known for
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87:(aged 75)
81:
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57:
55:
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50:
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15:
9:
6:
4:
3:
2:
1992:
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1896:
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1891:
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1886:
1883:
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1880:
1865:
1862:
1859:
1858:Edward Witten
1856:
1854:
1853:Gilbert Stork
1851:
1849:
1846:
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1841:
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1791:
1790:Tony Trewavas
1788:
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1743:John Ockendon
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1667:
1666:Raymond Dixon
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1592:
1591:Royal Society
1588:
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1569:
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1562:
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